propargylamine and betulin

propargylamine has been researched along with betulin* in 1 studies

Other Studies

1 other study(ies) available for propargylamine and betulin

Article	Year
Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis. Bioorganic & medicinal chemistry, 2013, Jan-15, Volume: 21, Issue:2 Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death. Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mice; NIH 3T3 Cells; Pargyline; Propylamines; Triterpenes	2013

Article

Year

Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis.

Bioorganic & medicinal chemistry, 2013, Jan-15, Volume: 21, Issue:2

Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death.

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mice; NIH 3T3 Cells; Pargyline; Propylamines; Triterpenes

2013