propargylamine and aminoacetone

propargylamine has been researched along with aminoacetone* in 1 studies

Other Studies

1 other study(ies) available for propargylamine and aminoacetone

Article	Year
Aminoacetone metabolism by semicarbazide-sensitive amine oxidase in rat aorta. Biochemical pharmacology, 1995, Jan-31, Volume: 49, Issue:3 High speed (105,000 g/60 min) membrane fractions from rat aorta homogenates metabolized the aliphatic amine aminoacetone (AA) to methylglyoxal (MG) with a Km of 19 +/- 3 microM, and Vmax of 510 +/- 169 nmol MG/hr/mg protein. This deaminating activity appears to be due to a semicarbazide-sensitive amine oxidase (SSAO), which is associated with smooth muscle cells in blood vessels of the rat and other species. AA was a competitive inhibitor (Ki of 28 +/- 6 microM) of the metabolism of benzylamine, a synthetic amine often used as an assay substrate for SSAO. AA is produced endogenously from mitochondrial metabolism of threonine and glycine, and thus could be a physiological substrate for SSAO, whereas the production of MG by SSAO could have cytotoxic implications for cellular function. Topics: Acetone; Amine Oxidase (Copper-Containing); Animals; Aorta; Benzylamines; Enzyme Activation; In Vitro Techniques; Kinetics; Male; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Propylamines; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Semicarbazides; Subcellular Fractions	1995

Article

Year

Aminoacetone metabolism by semicarbazide-sensitive amine oxidase in rat aorta.

Biochemical pharmacology, 1995, Jan-31, Volume: 49, Issue:3

High speed (105,000 g/60 min) membrane fractions from rat aorta homogenates metabolized the aliphatic amine aminoacetone (AA) to methylglyoxal (MG) with a Km of 19 +/- 3 microM, and Vmax of 510 +/- 169 nmol MG/hr/mg protein. This deaminating activity appears to be due to a semicarbazide-sensitive amine oxidase (SSAO), which is associated with smooth muscle cells in blood vessels of the rat and other species. AA was a competitive inhibitor (Ki of 28 +/- 6 microM) of the metabolism of benzylamine, a synthetic amine often used as an assay substrate for SSAO. AA is produced endogenously from mitochondrial metabolism of threonine and glycine, and thus could be a physiological substrate for SSAO, whereas the production of MG by SSAO could have cytotoxic implications for cellular function.

Topics: Acetone; Amine Oxidase (Copper-Containing); Animals; Aorta; Benzylamines; Enzyme Activation; In Vitro Techniques; Kinetics; Male; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Propylamines; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Semicarbazides; Subcellular Fractions

1995