propafenone has been researched along with verapamil in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (18.92) | 18.7374 |
| 1990's | 21 (28.38) | 18.2507 |
| 2000's | 24 (32.43) | 29.6817 |
| 2010's | 14 (18.92) | 24.3611 |
| 2020's | 1 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Burghofer, S; Chiba, P; Ecker, G; Moser, A; Richter, E; Tell, B | 1 |
| Chiba, P; Cordes, HP; Csöllei, J; Ecker, G; Hitzler, M; Schaper, KJ; Schmid, D; Seydel, JK; Visser, K | 1 |
| Bechmann, G; Chiba, P; Ecker, G; Hitzler, M; Holzer, W; Landau, M; Lorenz, K; Plagens, B; Richter, E | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Pajeva, IK; Wiese, M | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Kaur, J; Kaur, P; Kaur, S; Singh, P | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Abou-Taleb, N; Amblard, F; Amiralaei, S; Bassit, L; Coats, SJ; Domaoal, RA; Ehteshami, M; Khalil, A; Liu, P; Mahmoud, S; McBrayer, T; Ollinger Russell, O; Sari, O; Schinazi, RF; Schutter, C; Tao, S; Whitaker, T; Zhou, L; Zhou, S | 1 |
| Cabral, Ade M; de Oliveira, AM; Futuro Neto, Hde A | 1 |
| Kingma, JH; Suttorp, MJ | 1 |
| Kastrati, A; Kondili, A; Popa, Y | 1 |
| Bettini, R; Cozzi, F; Dal Forno, P; Furlanello, F | 1 |
| Somberg, J | 1 |
| Huang, SK; Marcus, FI | 1 |
| Bald, R; Gembruch, U; Hansmann, M | 1 |
| Schwartz, PJ; Vanoli, E | 1 |
| Condorelli, M; De Paola, M; Santinelli, V; Smimmo, D; Turco, P | 1 |
| Hirosawa, K; Kasanuki, H; Onishi, S | 1 |
| Camin, G; Disertori, M; Fiorentini, F; Furlanello, F; Guareneiro, M; Inama, G; Nicasi, L | 1 |
| Attuel, P; Coumel, P; Georgiopoulos, G; Halkidis, H; Leclercq, JF; Maisonblanche, P | 1 |
| Somberg, JC | 1 |
| Gmeiner, R; Sterz, H | 1 |
| Becker, HJ; Dowinsky, S; Hopf, R; Kaltenbach, M; Kober, G | 1 |
| Funke, H; Grube, E; Neumann, G | 1 |
| Bettini, R; Dal Forno, P; Disertori, M; Furlanello, F; Inama, G; Stefenelli, C; Vergara, G; Zuechi, S | 1 |
| Carlsson, B; Drvota, V; Häggblad, J; Sylvén, C | 1 |
| Bachernegg, M; Decrinis, M; Domanowits, H; Kickenweiz, E; Laggner, AN; Stark, G; Stark, U; Sterz, F; Tritthart, HA | 1 |
| Carbonieri, E; Marafioti, V; Zardini, P | 1 |
| Amici, R; Brun, M; Dormi, A; Giunti, M; Lanari, A; Mariani, A; Mariotti, V; Montanari, G; Volpe, P | 1 |
| Gessler, P; Haas, NA; König, SA; Pufahl, C; Teufel, M | 1 |
| Ganam, R; Ganem, R; Rabner, M; Weiner, P; Zidan, F | 1 |
| Lüderitz, B; Manz, M | 1 |
| Cronenberger, CL; Griffith, RK; Lalka, D | 1 |
| Camm, AJ; Fei, L; Gill, JS; McKenna, WJ | 1 |
| Jamali, F; Mehvar, R | 1 |
| Ito, S; Koren, G; Woodland, C | 1 |
| Chang, MS; Chen, SA; Ding, YA; Feng, AN; Kuo, BI; Lee, SH; Tai, CT; Yu, WC | 1 |
| Benet, LZ | 1 |
| Jochheim, R; Knaup, W; Müller, U; Tenholt, M | 1 |
| De Matteis, C; De Simone, A; Di Napoli, T; Di Stasio, M; Gasparini, M; Petrazzuoli, F; Rotunno, R; Stabile, G; Turco, P; Vitale, DF | 1 |
| Dell'Orfano, JT; Luck, JC; Naccarelli, GV; Patel, HM; Wolbrette, DL | 1 |
| Bagliani, G; Colella, A; Costoli, A; Franchi, F; Gensini, GF; Lazzeri, C; Michelucci, A; Padeletti, L; Pieragnoli, P; Sabini, A; Zipoli, R | 1 |
| Kawase, M; Motohashi, N | 1 |
| Sung, RJ | 1 |
| Kohno, Y; Suzuki, A; Yamamoto, T | 1 |
| Hengstler, JG; Hewitt, N; Oesch, F; Reder-Hilz, B; Ringel, M; Ullrich, M; Utesch, D | 1 |
| Freestone, B; Lip, GY | 2 |
| Lip, GY | 1 |
| Bett, GC; Chen, J; Huang, C; Jiang, X; Li, X; Rasmusson, RL; Wang, S; Xu, L | 1 |
| Baumert, C; Hilgeroth, A | 1 |
| Li, X; You, T; Zhu, D | 1 |
| Kryński, T; Kułakowski, P; Sikorska, A; Stec, S; Szymot, J; Zaborska, B | 1 |
| Pytkowski, M | 1 |
| Chen, L; Liang, D; Lin, J; Lin, Y; Qi, G; Tian, W; Wang, X | 1 |
| Duan, X; Gui, Y; Jia, J; Li, S; Liu, CC; Liu, G; Lu, Y; Zhang, M | 1 |
16 review(s) available for propafenone and verapamil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
[Long-term drug therapy of reciprocating supraventricular tachycardia: re-examination of a selected series of cases, using computerized programs].
Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Computers; Digoxin; Humans; Medigoxin; Middle Aged; Oxprenolol; Propafenone; Propiophenones; Sotalol; Tachycardia; Verapamil | 1980 |
[Treatment of angina pectoris with calcium antagonists].
Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Therapy, Combination; Exercise Test; Fendiline; Humans; Nicardipine; Nifedipine; Perhexiline; Prenylamine; Propafenone; Propiophenones; Verapamil | 1982 |
[Progress in arrhythmology].
Topics: Adolescent; Adult; Aged; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Cardiac Pacing, Artificial; Child; Electrocardiography; Exercise Test; Heart Conduction System; Humans; Middle Aged; Propafenone; Propiophenones; Sick Sinus Syndrome; Stimulation, Chemical; Verapamil; Wolff-Parkinson-White Syndrome | 1981 |
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy.
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil | 1993 |
The hepatic first-pass metabolism of problematic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Humans; Lidocaine; Liver; Metabolic Clearance Rate; Models, Biological; Nitroglycerin; Pharmaceutical Preparations; Propafenone; Propranolol; Verapamil | 1993 |
Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.
Topics: Adrenergic Uptake Inhibitors; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Area Under Curve; Computer Simulation; Disopyramide; Doxepin; Drug Interactions; Flurbiprofen; Food-Drug Interactions; Guidelines as Topic; Hydroxychloroquine; Ibuprofen; Nadolol; Nortriptyline; Propafenone; Stereoisomerism; Therapeutic Equivalency; Verapamil | 1997 |
Cost-effective management of acute atrial fibrillation: role of rate control, spontaneous conversion, medical and direct current cardioversion, transesophageal echocardiography, and antiembolic therapy.
Topics: Algorithms; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cost-Benefit Analysis; Echocardiography, Transesophageal; Electric Countershock; Flecainide; Humans; Procainamide; Propafenone; Quinidine; Sotalol; Verapamil | 2000 |
New multidrug resistance reversal agents.
Topics: Antineoplastic Agents; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Humans; Phenothiazines; Plant Preparations; Propafenone; Quinolines; Verapamil | 2003 |
Facilitating electrical cardioversion of persistant atrial fibrillation by antiarrhythmic drugs: update on clinical trial results.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Humans; Propafenone; Randomized Controlled Trials as Topic; Sotalol; Treatment Outcome; Verapamil | 2003 |
Atrial fibrillation (acute).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Timolol; Verapamil | 2003 |
Atrial fibrillation (acute).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil | 2004 |
Atrial fibrillation (recent onset).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil | 2005 |
Recent advances in the development of P-gp inhibitors.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Coumarins; Drug Design; Drug Resistance, Neoplasm; Flavonoids; Humans; Peptides; Propafenone; Propanolamines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolines; Structure-Activity Relationship; Tamoxifen; Terpenes; Verapamil | 2009 |
7 trial(s) available for propafenone and verapamil
| Article | Year |
|---|---|
Acute pharmacologic conversion of atrial fibrillation and flutter: the role of flecainide, propafenone, and verapamil.
Topics: Atrial Fibrillation; Atrial Flutter; Drug Evaluation; Female; Flecainide; Humans; Male; Middle Aged; Propafenone; Single-Blind Method; Time Factors; Verapamil | 1992 |
Comparative evaluation of verapamil, flecainide and propafenone for the acute conversion of atrial fibrillation to sinus rhythm.
Topics: Adult; Aged; Atrial Fibrillation; Electrocardiography; Female; Flecainide; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Propafenone; Verapamil | 1990 |
Action of ATP on ventricular automaticity.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Ajmaline; Animals; Anti-Arrhythmia Agents; Austria; Cardiac Pacing, Artificial; Drug Interactions; Emergency Medical Services; Female; Guinea Pigs; Heart Ventricles; Humans; Injections, Intravenous; Male; Propafenone; Prospective Studies; Quinidine; Tachycardia, Supraventricular; Ventricular Function; Verapamil | 1994 |
Clinical course of recent-onset atrial fibrillation treated with oral propafenone.
Topics: Administration, Oral; Aged; Atrial Fibrillation; Heart Rate; Humans; Middle Aged; Propafenone; Verapamil | 1994 |
Tachycardia-induced change of atrial refractory period in humans: rate dependency and effects of antiarrhythmic drugs.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrophysiology; Female; Humans; Male; Middle Aged; Pacemaker, Artificial; Procainamide; Propafenone; Propranolol; Sotalol; Tachycardia, Supraventricular; Verapamil | 1998 |
Pretreatment with verapamil in patients with persistent or chronic atrial fibrillation who underwent electrical cardioversion.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Combined Modality Therapy; Electric Countershock; Electrocardiography; Female; Humans; Male; Middle Aged; Premedication; Propafenone; Prospective Studies; Recurrence; Treatment Outcome; Verapamil | 1999 |
Benign symptomatic premature ventricular complexes: short- and long-term efficacy of antiarrhythmic drugs and radiofrequency ablation.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Catheter Ablation; Cross-Over Studies; Female; Follow-Up Studies; Humans; Male; Metoprolol; Middle Aged; Propafenone; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Ventricular Premature Complexes; Verapamil; Young Adult | 2012 |
51 other study(ies) available for propafenone and verapamil
| Article | Year |
|---|---|
Synthesis, pharmacologic activity, and structure-activity relationships of a series of propafenone-related modulators of multidrug resistance.
Topics: Daunorubicin; Drug Resistance, Multiple; Drug Synergism; Etoposide; Humans; Magnetic Resonance Spectroscopy; Propafenone; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzofurans; Calorimetry, Differential Scanning; Cells, Cultured; Daunorubicin; Drug Resistance, Multiple; Ethanolamines; Liposomes; Magnetic Resonance Spectroscopy; Membranes, Artificial; Propafenone; Regression Analysis; Rhodamine 123; Rhodamines; Structure-Activity Relationship | 1996 |
Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Humans; Isomerism; Magnetic Resonance Spectroscopy; Mice; Pyrazoles; Regression Analysis; Rhodamine 123; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results | 2006 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+.
Topics: Acridones; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Design; Drug Resistance, Multiple; Magnesium; Magnetic Resonance Spectroscopy; Models, Molecular; Spectrometry, Mass, Fast Atom Bombardment | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Topics: Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Genotype; Hep G2 Cells; Hepacivirus; Humans; Microbial Sensitivity Tests; Molecular Structure; Prodrugs; Ribonucleotides; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication | 2017 |
[Antagonism of angiotensin and vasopressin to the coronary vasodilating effect of verapamil and propafenon].
Topics: Angiotensin II; Animals; Blood Pressure; Guinea Pigs; Propafenone; Propiophenones; Vasopressins; Verapamil | 1979 |
Arrhythmogenic effects of antiarrhythmic drugs.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Flecainide; Humans; Male; Middle Aged; Propafenone; Risk Factors; Sotalol; Tachycardia; Verapamil | 1990 |
Direct intrauterine fetal treatment of fetal tachyarrhythmia with severe hydrops fetalis by antiarrhythmic drugs.
Topics: Anti-Arrhythmia Agents; Female; Fetal Diseases; Flecainide; Humans; Hydrops Fetalis; Medigoxin; Pregnancy; Propafenone; Tachycardia; Verapamil | 1988 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Ventricular parasystole and ventricular couplets: a re-entry within the parasystolic focus?
Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Male; Middle Aged; Myocardial Contraction; Procainamide; Propafenone; Systole; Verapamil | 1987 |
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil | 1985 |
[Effects of anti-arrhythmia agents on heart rate. Significance and importance].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disopyramide; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Lidocaine; Propafenone; Propiophenones; Quinidine; Verapamil | 1981 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
[Conservative therapy of supraventricular tachycardias].
Topics: Adrenergic beta-Antagonists; Ajmaline; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Digitalis Glycosides; Electrocardiography; Humans; Propafenone; Propiophenones; Tachycardia; Verapamil | 1984 |
[The value of antitachycardia pacemaker therapy in patients with Wolff-Parkinson-White syndrome].
Topics: Anti-Arrhythmia Agents; Bundle of His; Digitalis Glycosides; Disopyramide; Electrocardiography; Humans; Mexiletine; Pacemaker, Artificial; Propafenone; Propiophenones; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome | 1983 |
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect.
Topics: Amiodarone; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Metoprolol; Propafenone; Receptors, Thyroid Hormone; Sotalol; Triiodothyronine; Verapamil | 1995 |
Cases in electrocardiography.
Topics: Atrial Fibrillation; Electrocardiography; Female; Humans; Middle Aged; Propafenone; Tachycardia, Paroxysmal; Verapamil; Wolff-Parkinson-White Syndrome | 1995 |
[Propafenone and verapamil poisoning. Report of 2 clinical cases].
Topics: Adolescent; Female; Humans; Propafenone; Verapamil | 1994 |
[Adenosine triphosphate for supraventricular tachycardia in newborns and suckling infants].
Topics: Adenosine Triphosphate; Digoxin; Drug Therapy, Combination; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Female; Humans; Infant, Newborn; Propafenone; Tachycardia, Supraventricular; Verapamil; Wolff-Parkinson-White Syndrome | 1994 |
Effects of propafenone on calcium currents in single ventricular myocytes of guinea-pig.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium; Propafenone; Verapamil | 1993 |
A model for the prediction of digoxin-drug interactions at the renal tubular cell level.
Topics: Animals; Anti-Arrhythmia Agents; Antifungal Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cells, Cultured; Digoxin; Diuretics; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Hormone Antagonists; Immunosuppressive Agents; Kidney Tubules; Male; Models, Biological; Propafenone; Swine; Verapamil | 1998 |
Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation.
Topics: Administration, Oral; Drug Monitoring; Graft Rejection; Humans; Immunosuppressive Agents; Loratadine; Propafenone; Selegiline; Treatment Outcome; Verapamil | 1998 |
[Implantable event recorder: a new aid for the diagnosis of arrhythmogenic syncope].
Topics: Anti-Arrhythmia Agents; Atrial Premature Complexes; Digitalis Glycosides; Drug Eruptions; Electrocardiography, Ambulatory; Electrophysiology; Female; Humans; Middle Aged; Propafenone; Prostheses and Implants; Syncope; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular; Verapamil | 1998 |
Altered values of heart rate variability in patients with relapse of atrial fibrillation during the first week after electrical cardioversion: preliminary data.
Topics: Aged; Amiodarone; Atrial Fibrillation; Circadian Rhythm; Electric Countershock; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Middle Aged; Observer Variation; Predictive Value of Tests; Propafenone; Recurrence; Sensitivity and Specificity; Time Factors; Vasodilator Agents; Verapamil | 2001 |
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil | 2004 |
Metabolism of propafenone and verapamil by cryopreserved human, rat, mouse and dog hepatocytes: comparison with metabolism in vivo.
Topics: Aged; Animals; Anti-Arrhythmia Agents; Cryopreservation; Dogs; Glucuronides; Hepatocytes; Humans; In Vitro Techniques; Mice; Middle Aged; Propafenone; Rats; Rats, Sprague-Dawley; Species Specificity; Time Factors; Verapamil | 2004 |
Effect of amiodarone on Kv1.4 channel C-type inactivation: comparison of its effects with those induced by propafenone and verapamil.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Female; Kv1.4 Potassium Channel; Oocytes; Patch-Clamp Techniques; Propafenone; Verapamil; Xenopus laevis; Xenopus Proteins | 2008 |
Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach.
Topics: Analysis of Variance; Cardiovascular Agents; Electrophoresis, Capillary; Female; Humans; Hydrogen-Ion Concentration; Luminescent Measurements; Models, Chemical; Propafenone; Propanolamines; Regression Analysis; Reproducibility of Results; Research Design; Sensitivity and Specificity; Verapamil | 2011 |
[Not so simple procedure in "simple" arrhythmias of ventricular].
Topics: Anti-Arrhythmia Agents; Catheter Ablation; Female; Humans; Male; Metoprolol; Propafenone; Ventricular Premature Complexes; Verapamil | 2012 |
Treatment with verapamil for restoration of sinus rhythm in atrial fibrillation with rapid ventricular response: A case report.
Topics: Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Female; Humans; Propafenone; Verapamil | 2019 |
Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring.
Topics: Amiodarone; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Computer Systems; Diltiazem; Drug Monitoring; Humans; Metoprolol; Pharmaceutical Preparations; Propafenone; Tandem Mass Spectrometry; Verapamil | 2020 |