Page last updated: 2024-08-16

propafenone and propranolol

propafenone has been researched along with propranolol in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (26.32)	18.7374
1990's	5 (13.16)	18.2507
2000's	13 (34.21)	29.6817
2010's	9 (23.68)	24.3611
2020's	1 (2.63)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Pajeva, IK; Wiese, M	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R	1
Futuro Neto, Hde A; Mill, JG; Vassallo, DV	1
Cantor, E; Greenberg, S; Paul, J	1
Jähnchen, E; Trenk, D; Wagner, F	1
Fu, CH; Kirsten, EB; Kowey, PR; Mason, WD	1
Bolognesi, R; Manca, C; Poli, E; Raddino, R; Visioli, O	1
Schwartz, PJ; Vanoli, E	1
Alboni, P; Candini, GC; Masoni, A; Paparella, N; Pirani, R; Tomasi, AM	1
Gang, ES; Hamer, A; Mandel, WJ; Oseran, DS; Peter, T; Rosenthal, ME	1
McLeod, AA; Shand, DG; Stiles, GL	1
Beck, OA; Hochrein, H; Ihle, C	1
Barr, WH; Dee, CM; Duerr, H; Hinderling, PH; Seiberling, M; Tendolkar, A	1
Malfatto, G; Pessano, P; Schwartz, PJ; Zaza, A	1
Cronenberger, CL; Griffith, RK; Lalka, D	1
Ceremuzynski, L; Czepiel, A; Karczmarewicz, S; Karpinski, G; Kulakowski, P; Makowska, E; Wolk, R	1
Chang, MS; Chen, SA; Ding, YA; Feng, AN; Kuo, BI; Lee, SH; Tai, CT; Yu, WC	1
Hu, XY; Yao, TW	1
Iwaki, M; Komura, H	1

Reviews

2 review(s) available for propafenone and propranolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The hepatic first-pass metabolism of problematic drugs. Journal of clinical pharmacology, 1993, Volume: 33, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Humans; Lidocaine; Liver; Metabolic Clearance Rate; Models, Biological; Nitroglycerin; Pharmaceutical Preparations; Propafenone; Propranolol; Verapamil	1993

Trials

5 trial(s) available for propafenone and propranolol

Article	Year
Evaluation of the beta-adrenoceptor blocking activity of the Class Ic antiarrhythmic drug diprafenone in man. European journal of clinical pharmacology, 1989, Volume: 36, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Isoproterenol; Male; Propafenone; Propranolol; Random Allocation	1989
[Propafenon and propranolol in the management of cardiac extrasystoles (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1982, Apr-16, Volume: 107, Issue:15 Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Propafenone; Propiophenones; Propranolol	1982
Single-dose interaction study of diprafenone HCl and propranolol HCl in healthy volunteers. Journal of clinical pharmacology, 1995, Volume: 35, Issue:7 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Drug Administration Schedule; Drug Combinations; Drug Interactions; Electrocardiography; Exercise Test; Half-Life; Heart Rate; Humans; Male; Propafenone; Propranolol; Rest; Sensitivity and Specificity	1995
The incidence of asymptomatic paroxysmal atrial fibrillation in patients treated with propranolol or propafenone. International journal of cardiology, 1996, Volume: 54, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography, Ambulatory; Evaluation Studies as Topic; Female; Humans; Incidence; Male; Middle Aged; Prognosis; Propafenone; Propranolol; Risk Factors; Tachycardia, Paroxysmal	1996
Tachycardia-induced change of atrial refractory period in humans: rate dependency and effects of antiarrhythmic drugs. Circulation, 1998, Jun-16, Volume: 97, Issue:23 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrophysiology; Female; Humans; Male; Middle Aged; Pacemaker, Artificial; Procainamide; Propafenone; Propranolol; Sotalol; Tachycardia, Supraventricular; Verapamil	1998

Other Studies

31 other study(ies) available for propafenone and propranolol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Determination of log D via automated microfluidic liquid-liquid extraction. Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16 Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. Journal of medicinal chemistry, 2021, 06-24, Volume: 64, Issue:12 Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; HEK293 Cells; Humans; Molecular Structure; Orphan Nuclear Receptors; Propranolol; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship	2021
[Effect of propafenon on isometric contraction of isolated atrium in mammals]. Arquivos brasileiros de cardiologia, 1979, Volume: 33, Issue:4 Topics: Animals; Calcium; Depression, Chemical; Drug Interactions; Heart Atria; Myocardial Contraction; Propafenone; Propiophenones; Propranolol; Rabbits	1979
Beta-adrenoceptor blocking activity of diprafenone in anesthetized dogs: comparison with propafenone and propranolol. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:3 Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Anti-Arrhythmia Agents; Dihydroalprenolol; Dogs; Female; Heart; Isoproterenol; Male; Membranes; Myocardium; Propafenone; Propranolol; Receptors, Adrenergic, beta	1989
Interaction between propranolol and propafenone in healthy volunteers. Journal of clinical pharmacology, 1989, Volume: 29, Issue:6 Topics: Adult; Drug Interactions; Electrocardiography; Hemodynamics; Humans; Male; Propafenone; Propranolol	1989
Effects of 17 beta-estradiol on the isolated rabbit heart. Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 281, Issue:1 Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vasospasm; Depression, Chemical; Estradiol; Female; Heart; Histamine; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Nifedipine; Nitroglycerin; Propafenone; Propiophenones; Propranolol; Rabbits; Vascular Resistance; Vasopressins	1986
An experimental approach to the choice of antiarrhythmic therapy. European heart journal, 1986, Volume: 7 Suppl A Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil	1986
A method for evaluating different modes of action of an antiarrhythmic drug in man. The effects of propafenone on sinus nodal functions. International journal of cardiology, 1985, Volume: 7, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Autonomic Nervous System; Bundle-Branch Block; Cardiac Pacing, Artificial; Coronary Disease; Electrocardiography; Female; Heart Block; Humans; Hypertension; Male; Middle Aged; Mitral Valve Prolapse; Propafenone; Propiophenones; Propranolol; Sinoatrial Node	1985
The yield of programmed ventricular stimulation in mitral valve prolapse patients with ventricular arrhythmias. American heart journal, 1985, Volume: 110, Issue:5 Topics: Adult; Amiodarone; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Female; Heart Arrest; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Mitral Valve Prolapse; Procainamide; Propafenone; Propiophenones; Propranolol; Risk	1985
Demonstration of beta adrenoceptor blockade by propafenone hydrochloride: clinical pharmacologic, radioligand binding and adenylate cyclase activation studies. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:2 Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Adult; Animals; Anti-Arrhythmia Agents; Double-Blind Method; Electrocardiography; Enzyme Activation; Erythrocyte Membrane; Humans; Male; Physical Exertion; Propafenone; Propiophenones; Propranolol; Radioligand Assay; Ranidae; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Tachycardia	1984
Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance. European heart journal, 1993, Volume: 14, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cats; Electric Stimulation; Electrocardiography; Female; Flecainide; Heart Rate; Male; Propafenone; Propranolol	1993
[Interaction between ipriflavone and other drugs in metabolism in vitro]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:1 Topics: Animals; Drug Interactions; Estradiol; Female; Isoflavones; Propafenone; Propranolol; Rats; Rats, Sprague-Dawley	2004
Usefulness of hepatocytes for evaluating the genetic polymorphism of CYP2D6 substrates. Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:6 Topics: Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Genetic Techniques; Hepatocytes; Humans; Metoprolol; Microsomes, Liver; Polymorphism, Genetic; Propafenone; Propranolol; Quinidine	2005