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propafenone and 5-hydroxypropafenone

propafenone has been researched along with 5-hydroxypropafenone in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (35.09)	18.7374
1990's	23 (40.35)	18.2507
2000's	10 (17.54)	29.6817
2010's	4 (7.02)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fleischer, R; Wiese, M	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Chiba, P; de Laet, R; Ecker, GF; Gasteiger, J; Kaiser, D; Kopp, S; Schulz, J; Terfloth, L	1
Tang, YN; Zhang, WL	1
Axelson, JE; Kerr, CR; Tonn, GR	1
Belloni, M; Bernasconi, R; Cappiello, E; Castel, JM; Giani, P; Landolina, M; Latini, R; Leopaldi, D	1
Follath, F; Ha, HR; Oti-Amoako, K; Vozeh, S	1
Case, CL; Gillette, PC; Hewett, KW; Maheshwari, R; Ravin, RR	1
Leloux, MS; Maes, RA	1
Busato, E; Libardoni, M; Padrini, R; Piovan, D	1
Follath, F; Ha, HR; Haefeli, WE; Taeschner, W; Vozeh, S	1
Frey, B; Plass, H; Probst, P; Pürerfellner, H; Schmidinger, H; Steurer, G; Weber, H	1
Ambrosioni, E; Balducelli, M; Boriani, G; Capucci, A; Frabetti, L; Magnani, B; Marchesini, B; Strocchi, E; Tomasi, L	1
Follath, F; Ha, HR; Haefeli, W; Vlcek, J; Vozeh, S	1
Delgado, C; Tamargo, J; Valenzuela, C	1
Delpón, E; Tamargo, J; Valenzuela, C	1
Adamantidis, MM; Broly, F; Caron, JF; Dupuis, BA; Honore, E; Libersa, CC; Rouet, R; Wajman, A	1
Abbott, FS; Axelson, JE; Chan, GL; Kerr, CR; McErlane, KM	1
Erstad, BL; Furman, C; Hoyer, GL; Kirsten, EB; Marcus, FI; Nolan, PE	1
Funck-Brentano, C; Kroemer, HK; Pavlou, H; Roden, DM; Woosley, RL	1
Brewington, J; Kirsten, EB; Zoble, RG	1
Delgado, C; Tamargo, J; Tejerina, T; Valenzuela, C	1
Barbieri, E; Castello, C; Gerosa, G; Latini, R; Marchi, S; Rossi, R; Sica, A; Zardini, P	1
Hege, HG; Neidlein, R; Wu, M	1
Iansmith, DH; Roden, DM; Siddoway, LA; Thompson, KA; Woosley, RL	1
Benfenati, E; Chen, ZM; Gavinelli, M; Latini, R; Marchi, S; Sica, A	1
Bianchini, C; Ferrario, G; Giani, P; Giudici, V; Landolina, M; Latini, R; Marchi, S; Riva, E	1
Breckwoldt, W; Brode, E; Kripp, U	1
Danilo, P; Forster, M; Malfatto, G; Rosen, MR; Sodowick, B; Zaza, A	1
Cavalli, A; Cazzaniga, MG; Latini, R; Maggioni, AP; Marchi, S; Riva, E; Volpi, A	1
McAllister, CB; Roden, DM; Siddoway, LA; Thompson, KA; Wang, T; Wilkinson, GR; Woosley, RL	1
Kates, RE; Winkle, RA; Yee, YG	1
Brode, E; Hollmann, M; Kripp, U	1
Gries, J; Hofmann, HP; Kreiskott, H; Kretzschmar, R; Müller, CD; Raschack, M; Teschendorf, HJ; von Philipsborn, G	1
Böhm, R; Ellrich, R; Koytchev, R	1
Liu, L; Tang, YN; Wang, ZY; Zhang, WL	1
Kern, R	1
Mizuochi, M; Morita, K; Yamaji, A; Yokoyama, T	1
Boucher, M; Chassaing, C; Hamel, JD; Poirier, JM	1
Giesbrecht, E; Ito, S; Koren, G; Verjee, Z; Woodland, C	1
Axelson, JE; Dodo, H; Freedom, R; Giesbrecht, E; Gow, R; Ito, S; Koren, G; Rosenberg, HC; Tonn, GR; Verjee, Z; Zalzstein, E	1
Belpaire, F; Buylaert, W; Calle, P; Fonck, K; Haenebalcke, C; Hemeryck, A; Jordaens, L	1
Caballero, R; Delpón, E; Franqueza, L; Longobardo, M; Tamargo, J; Valenzuela, C	1
Brandsteterová, E; Kubalec, P	1
Blume, H; Chen, X; Zhong, D	1
Bertucci, C; Bonato, PS; Cesarino, EJ; Lanchote, VL; Pires de Abreu, LR	1
Chow, MS; Fan, C; Lau, CP; Tang, MO; White, CM	1
Cahill, SA; Gross, GJ; Kirshenbaum, LA	1
Chen, X; Gu, J; Jiang, H; Zhong, D	1
Arias, C; Caballero, R; Delpón, E; González, T; Moreno, I; Tamargo, J; Valenzuela, C	1
Cahill, SA; Gross, GJ	1
Bachmakov, I; Eichelbaum, M; Fromm, MF; Hofmann, U; Rekersbrink, S	1
Afshar, M; Thormann, W	1
Dargan, PI; Jones, AL; Ludman, A; Ovaska, H; Spencer, EP; Wood, DM	1
Afshar, M; Rouini, MR	1
Bhatt, C; Desai, N; Ghoghari, A; Jha, A; Patel, H; Shah, S; Srinivas, NR	1
Chi, Z; Ding, L; Li, Y; Liu, R; Shu, C; Wang, K	1

Trials

3 trial(s) available for propafenone and 5-hydroxypropafenone

Article	Year
Concentration-effect relations of 5-hydroxypropafenone in normal subjects. The American journal of cardiology, 1991, May-01, Volume: 67, Issue:11 Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Blood Pressure; Double-Blind Method; Electrocardiography; Female; Half-Life; Humans; Male; Posture; Propafenone; Reference Values	1991
Pharmacokinetic and pharmacodynamic evaluation of propafenone in patients with ventricular arrhythmia. Propafenone Research Group. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Middle Aged; Propafenone; Random Allocation	1989
A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in positive mode. Biomedical chromatography : BMC, 2017, Volume: 31, Issue:10 Topics: Administration, Oral; Chromatography, Liquid; Drug Stability; Edetic Acid; Humans; Limit of Detection; Linear Models; Propafenone; Reproducibility of Results; Tandem Mass Spectrometry	2017

Other Studies

54 other study(ies) available for propafenone and 5-hydroxypropafenone

Article	Year
Three-dimensional quantitative structure-activity relationship analysis of propafenone-type multidrug resistance modulators: influence of variable selection on test set predictivity. Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23 Topics: Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterocyclic Compounds; Hydrophobic and Hydrophilic Interactions; Molecular Conformation; Predictive Value of Tests; Propafenone; Quantitative Structure-Activity Relationship; Static Electricity	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
Self-organizing maps for identification of new inhibitors of P-glycoprotein. Journal of medicinal chemistry, 2007, Apr-05, Volume: 50, Issue:7 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Databases, Factual; Drug Resistance; Propafenone; Quantitative Structure-Activity Relationship	2007
[Simultaneous determination of propafenone and its active metabolite in serum by high performance liquid chromatography]. Yao xue xue bao = Acta pharmaceutica Sinica, 1992, Volume: 27, Issue:7 Topics: Anti-Arrhythmia Agents; Humans; Propafenone	1992
In vitro protein binding of propafenone and 5-hydroxypropafenone in serum, in solutions of isolated serum proteins, and to red blood cells. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:11 Topics: Anti-Arrhythmia Agents; Blood Proteins; Cells, Cultured; Erythrocytes; Humans; Lipoproteins; Male; Propafenone; Reference Values; Solutions	1992
Identification of propafenone metaboliser phenotype from plasma and urine excretion data. European journal of clinical pharmacology, 1992, Volume: 42, Issue:1 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Debrisoquin; Female; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Propafenone	1992
The relative potency of major metabolites and enantiomers of propafenone in an experimental reperfusion arrhythmia model. Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Biotransformation; Chromatography, High Pressure Liquid; Male; Myocardial Reperfusion Injury; Propafenone; Rats; Rats, Inbred Strains; Stereoisomerism	1990
Developmental electrophysiologic effects of propafenone and 5-hydroxypropafenone on the canine cardiac Purkinje fiber. Developmental pharmacology and therapeutics, 1991, Volume: 17, Issue:1-2 Topics: Age Factors; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Female; Male; Membrane Potentials; Propafenone; Purkinje Fibers	1991
Identification and determination of propafenone and its principal metabolites in human urine using capillary gas chromatography/mass spectrometry. Biological mass spectrometry, 1991, Volume: 20, Issue:6 Topics: Gas Chromatography-Mass Spectrometry; Humans; Propafenone	1991
Transfer of propafenone and 5-OH-propafenone to foetal plasma and maternal milk. British journal of clinical pharmacology, 1991, Volume: 32, Issue:4 Topics: Adult; Animals; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Milk; Pregnancy; Propafenone	1991
Plasma propafenone concentration in the evaluation of anti-arrhythmic efficacy. European heart journal, 1991, Volume: 12, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Chi-Square Distribution; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Propafenone; Ventricular Function, Left	1991
Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy. Cardiovascular drugs and therapy, 1990, Volume: 4, Issue:1 Topics: Administration, Oral; Adult; Aged; Debrisoquin; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Phenotype; Propafenone; Time Factors	1990
Nonlinear kinetics of propafenone metabolites in healthy man. European journal of clinical pharmacology, 1990, Volume: 38, Issue:5 Topics: Biotransformation; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Injections, Intravenous; Male; Propafenone	1990
Electrophysiological effects of 5-hydroxypropafenone on guinea pig ventricular muscle fibers. Journal of cardiovascular pharmacology, 1987, Volume: 10, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Male; Membrane Potentials; Papillary Muscles; Propafenone	1987
Tonic and phasic Vmax block induced by 5-hydroxypropafenone in guinea pig ventricular muscles. Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Membrane Potentials; Papillary Muscles; Propafenone	1988
Comparative electrophysiological effects of propafenone, 5-hydroxy-propafenone, and N-depropylpropafenone on guinea pig ventricular muscle fibers. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:4 Topics: Action Potentials; Animals; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Membrane Potentials; Papillary Muscles; Propafenone	1989
Determination of 5-hydroxypropafenone in biological fluids by fused-silica capillary gas chromatography using electron-capture detection. Journal of chromatography, 1989, Oct-27, Volume: 495 Topics: Chromatography, Gas; Humans; Mass Spectrometry; Propafenone	1989
Effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects. Journal of clinical pharmacology, 1989, Volume: 29, Issue:1 Topics: Adult; Digoxin; Drug Interactions; Half-Life; Humans; Male; Propafenone	1989
Genetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect. British journal of clinical pharmacology, 1989, Volume: 27, Issue:4 Topics: Adult; Aged; Arrhythmias, Cardiac; Biotransformation; Electrocardiography; Female; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Propafenone; Quinidine	1989
Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres. British journal of pharmacology, 1987, Volume: 90, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Electric Stimulation; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Membrane Potentials; Propafenone	1987
Propafenone and 5-hydroxypropafenone concentrations in the right atrium of patients undergoing heart surgery. American heart journal, 1989, Volume: 117, Issue:2 Topics: Adult; Cardiac Surgical Procedures; Female; Heart Atria; Humans; Middle Aged; Myocardium; Osmolar Concentration; Propafenone	1989
Synthesis of glucuronides of propafenone and 5-hydroxypropafenone by Sepharose-bound uridine 5'-diphosphoglucuronyltransferase. Arzneimittel-Forschung, 1988, Volume: 38, Issue:9 Topics: Animals; Chromatography; Chromatography, High Pressure Liquid; Dogs; Enzymes, Immobilized; Glucuronates; Glucuronosyltransferase; Humans; Kinetics; Mass Spectrometry; Propafenone; Uridine Diphosphate Glucuronic Acid	1988
Potent electrophysiologic effects of the major metabolites of propafenone in canine Purkinje fibers. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3 Topics: Action Potentials; Animals; Biotransformation; Dogs; Heart Conduction System; In Vitro Techniques; Propafenone; Purkinje Fibers	1988
High-performance liquid chromatographic separation and mass spectrometric identification of propafenone, 5-hydroxypropafenone and N-depropylpropafenone. Journal of chromatography, 1988, Jan-22, Volume: 424, Issue:1 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Propafenone	1988
Pharmacokinetics and pharmacodynamics of propafenone during acute and chronic administration. European journal of clinical pharmacology, 1988, Volume: 34, Issue:2 Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Electrocardiography; Female; Half-Life; Humans; Male; Middle Aged; Propafenone	1988
HPLC determination of 5-hydroxypropafenone in plasma with electrochemical detection. Methods and findings in experimental and clinical pharmacology, 1988, Volume: 10, Issue:5 Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hydrogen-Ion Concentration; Propafenone	1988
Electrophysiologic, inotropic and antiarrhythmic effects of propafenone, 5-hydroxypropafenone and N-depropylpropafenone. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Propafenone; Purkinje Fibers; Tachycardia	1988
Distribution of propafenone and its active metabolite, 5-hydroxypropafenone, in human tissues. American heart journal, 1987, Volume: 113, Issue:3 Topics: Anti-Arrhythmia Agents; Humans; Male; Middle Aged; Propafenone; Tissue Distribution	1987
Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences. Circulation, 1987, Volume: 75, Issue:4 Topics: Adult; Aged; Arrhythmias, Cardiac; Cytochrome P-450 CYP2D6; Debrisoquin; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; In Vitro Techniques; Kinetics; Liver; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Propafenone; Time Factors	1987
Metabolite cumulation during chronic propafenone dosing in arrhythmia. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:6 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Humans; Male; Middle Aged; Propafenone; Propiophenones; Time Factors	1985
Simultaneous determination of propafenone and 5-hydroxypropafenone in plasma by means of high pressure liquid chromatography. Arzneimittel-Forschung, 1984, Volume: 34, Issue:11 Topics: Adrenergic beta-Antagonists; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Propafenone; Propiophenones	1984
Pharmacological studies on propafenone and its main metabolite 5-hydroxypropafenone. Arzneimittel-Forschung, 1984, Volume: 34, Issue:11 Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Calcium Channel Blockers; Dogs; Electrocardiography; Electroencephalography; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Propafenone; Propiophenones; Rabbits; Rats; Rats, Inbred Strains; Tachycardia	1984
Quantitation of R- and S-propafenone and of the main metabolite in plasma. Die Pharmazie, 1995, Volume: 50, Issue:8 Topics: Adrenergic beta-Antagonists; Biotransformation; Chromatography, High Pressure Liquid; Humans; Propafenone; Spectrophotometry, Ultraviolet; Stereoisomerism	1995
[Metabolism of propafenone and lidocaine in combination in rat liver supernatant]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:6 Topics: Animals; Drug Synergism; Lidocaine; Liver; Male; Propafenone; Rats; Rats, Wistar	1994
Internally standardized simultaneous assay of propafenone and 5-hydroxypropafenone enantiomers in human plasma by means of high performance liquid chromatography. Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:3 Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Humans; Propafenone; Spectrophotometry, Ultraviolet; Stereoisomerism	1994
Stereoselectivity in the hydroxylation of propafenone enantiomers in mouse hepatic microsomes. Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:4 Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Propafenone; Stereoisomerism	1994
Cardiac electrophysiological effects of propafenone and its 5-hydroxylated metabolite in the conscious dog. European journal of pharmacology, 1996, Nov-14, Volume: 315, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; Injections, Intravenous; Male; Propafenone	1996
The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Dogs; Drug Interactions; Female; Kidney Tubules; Propafenone; Vinblastine	1997
Intravenous and oral propafenone for treatment of tachycardia in infants and children: pharmacokinetics and clinical response. Journal of clinical pharmacology, 1998, Volume: 38, Issue:6 Topics: Administration, Oral; Anti-Arrhythmia Agents; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Male; Metabolic Clearance Rate; Propafenone; Tachycardia; Treatment Outcome	1998
ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning. Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:3 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Electrocardiography; Female; Half-Life; Heart; Humans; Middle Aged; Poisoning; Propafenone	1998
Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels. British journal of pharmacology, 1998, Volume: 125, Issue:5 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Humans; Kv1.5 Potassium Channel; Mice; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Propafenone; Time Factors	1998
Determination of propafenone and its main metabolite 5-hydroxypropafenone in human serum with direct injection into a column-switching chromatographic system. Journal of chromatography. B, Biomedical sciences and applications, 1999, Apr-16, Volume: 726, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Humans; Propafenone; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet	1999
Stereoselective pharmacokinetics of propafenone and its major metabolites in healthy Chinese volunteers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 10, Issue:1 Topics: Adult; Anti-Arrhythmia Agents; Asian People; Glucuronides; Humans; Male; Propafenone	2000
Simultaneous determination of propafenone and 5-hydroxypropafenone enantiomers in plasma by chromatography on an amylose derived chiral stationary phase. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 20, Issue:1-2 Topics: Amylose; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Methylene Chloride; Propafenone; Reproducibility of Results; Solutions; Stereoisomerism	1999
Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation. Journal of clinical pharmacology, 2001, Volume: 41, Issue:1 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; China; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Excitatory Amino Acid Antagonists; Female; Hong Kong; Humans; Male; Middle Aged; Oxidation-Reduction; Propafenone	2001
Transient outward current inhibition by propafenone and 5-hydroxypropafenone in cultured neonatal rat ventricular myocytes. Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:3 Topics: Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cells, Cultured; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Humans; Ion Channels; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Propafenone; Rats; Rats, Sprague-Dawley	2001
[Characterization of some glucuronide conjugates by electrospray ion trap mass spectrometry]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:11 Topics: Animals; Glucuronides; Humans; Molecular Structure; Propafenone; Rabbits; Spectrometry, Mass, Electrospray Ionization	1998
Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels. Cardiovascular research, 2003, Volume: 57, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Propafenone	2003
Propafenone and its metabolites preferentially inhibit IKr in rabbit ventricular myocytes. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Heart Ventricles; Male; Myocardium; Myocytes, Cardiac; Potassium Channels; Propafenone; Rabbits	2004
Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein. Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:3 Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cyclosporins; Digoxin; Dose-Response Relationship, Drug; Humans; Propafenone; Stereoisomerism	2005
Validated capillary electrophoresis assay for the simultaneous enantioselective determination of propafenone and its major metabolites in biological samples. Electrophoresis, 2006, Volume: 27, Issue:8 Topics: Anti-Arrhythmia Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Microsomes, Liver; Propafenone; Reproducibility of Results; Stereoisomerism	2006
Propafenone poisoning--a case report with plasma propafenone concentrations. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:1 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Coma; Combined Modality Therapy; Drug Overdose; Electrocardiography; Humans; Male; Middle Aged; Poisoning; Propafenone; Seizures; Shock, Cardiogenic; Spectrophotometry, Ultraviolet; Treatment Outcome	2010
Effect of CYP2D6 polymorphisms on the pharmacokinetics of propafenone and its two main metabolites. Therapie, 2017, Volume: 72, Issue:3 Topics: Adult; Anti-Arrhythmia Agents; Cytochrome P-450 CYP2D6; Female; Humans; Male; Middle Aged; Polymorphism, Genetic; Propafenone; Young Adult	2017
A Sensitive and Rapid LC-MS-MS Method for Simultaneous Determination of Propafenone and Its Active Metabolite 5-Hydroxypropafenone in Human Plasma and Its Application in a Pharmacokinetic Study. Journal of chromatographic science, 2017, Oct-01, Volume: 55, Issue:9 Topics: Adult; Chromatography, Liquid; Humans; Limit of Detection; Linear Models; Propafenone; Reproducibility of Results; Tandem Mass Spectrometry; Young Adult	2017