Page last updated: 2024-08-23

promegestone and trimegestone

promegestone has been researched along with trimegestone in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.08)18.7374
1990's9 (18.37)18.2507
2000's34 (69.39)29.6817
2010's2 (4.08)24.3611
2020's2 (4.08)2.80

Authors

AuthorsStudies
Akimoto, S; Fuse, H; Kodama, T; Sato, R; Shimazaki, J; Zama, S1
Abendstein, B; Daxenbichler, G; Marth, C1
Cooper, A; Godfree, V; Pryse-Davies, J; Ross, D; Whitehead, MI1
Al-Azzawi, F; Thompson, J; Thompson, W; Wahab, M; Whitehead, M1
Al-Azzawi, F; Thompson, J; Wahab, M3
Kenemans, P; Smolders, RG; Teerlink, T; van Baal, WM; van der Mooren, MJ1
Al-Azzawi, F; Deen, S; Hamid, B; Thompson, J; Wahab, M1
Emeis, JJ; Kenemans, P; Kessel, H; Peters-Muller, ER; Schalkwijk, CG; Stehouwer, CD; Van Baal, WM; van der Mooren, MJ1
Bouchoux, F; Degryse, M; Gaillard, M; Lecaque, D; Petit, F; Philibert, D1
Azerad, R; Biton, J; Lacroix, I1
Bécourt, P; Couarraze, G; Maillard-Salin, DG2
Benhamou, B; Gofflo, D; Guillot, B; Moras, D; Ossart, C; Philibert, D; Robin-Jagerschmidt, C; Vergezac, A; Wurtz, JM1
Bouali, Y; Gaillard-Kelly, M; Marie, PJ1
Gaillard-Kelly, M; Lepescheux, L; Miller, P; Secchi, J1
Carver, JM; Lundeen, SG; Winneker, RC; Zhang, Z; Zhu, Y1
Beijers-De Bie, L; De Villiers, TJ; Houben, PW; Magaril, C; Meuwissen, JH; Murga, M; Siseles, N; Spielmann, D; The, HS; Tuimala, R; Vihtamaki, T2
al-Azzawi, F; Dillon, J; Hirvonen, E; Magaril, C; Pornel, B; Thompson, J; van der Mooren, MJ; Wahab, M; Ylikorkala, O1
Al-Azzawi, F; Wahab, M1
Emeis, JJ; Hendriks, DF; Kenemans, P; Leurs, JR; Post, MS; Stehouwer, CD; Van Baal, WM; Van Der Mooren, MJ1
Al-Azzawi, F; Thompson, J; Wahab, M; Whitehead, M1
Gaspard, U1
Dräger, AM; Huijgens, PC; Kenemans, P; Stehouwer, CD; Thijs, A; van Baal, WM; van der Mooren, MJ1
Kenemans, P; Post, MS; Rosing, J; Stehouwer, CD; Van Baal, WM; Van Der Mooren, MJ; Zweegman, S1
Kenemans, P; Post, MS; Stehouwer, CD; Teerlink, T; van der Mooren, MJ; Verhoeven, MO1
Bitran, D; Winneker, RC; Zhang, Z1
Constantine, G; Grubb, G; Pickar, J; Spielmann, D1
Nilsson, S; Ulfberg, J; Wesström, J1
Al-Azzawi, F; Proudler, AJ; Sami, S; Stevenson, J; Thompson, J; Wahab, M1
Shirk, RA; Winneker, RC; Zhang, Z1
Appavu, C; Berrodin, T; Chippari, S; Chopra, R; Cohen, J; Fensome, A; Li, S; Lyttle, CR; Olland, AM; Unwalla, RJ; Wilhem, J; Winneker, RC; Wrobel, J; Zhang, P; Zhang, Z; Zhu, Y1
Bray, JA; Bray, JD; Brown, EL; Ghatge, R; Horwitz, KB; Jacobsen, BM; Jelinsky, S; Lyttle, CR; Richer, JK; Saraf, K; Tunkey, C; Winneker, RC1
Gambacciani, M; Genazzani, AR; Spielmann, D1
Pornel, B; Spielmann, D1
Koninckx, PR; Spielmann, D1
Bouchard, P; De Cicco-Nardone, F; Garcea, N; Spielmann, D1
Al-Azzawi, F; Pringle, JH; Taylor, AH; Thompson, J; Wahab, M1
Bossemeyer, R; Bouchard, P; Sitruk-Ware, R1
Christiansen, C; Loog, M; Nielsen, M; Pettersen, PC; Raundahl, J; Tankó, LB1
Bonnar, J; Brosnan, J; Conard, J; Hellgren, M; Kluft, C; Norris, LA1
Conard, J; Hellgren, M; Kluft, C; Norris, L1
Martinez, D; Silva, BH; Wender, MC1
Carvalho, SL; Collaço, LM; Cordeiro Júnior, DG; Lago, VV; Marques, Lde O; Sobral, AC1
Dax, A; Draeger, C; Duijkers, IJM; Friedrich, M; Klipping, C; Nickisch, K; Schug, BS1
de Jesus Antunes, N; De Nucci, G; de Oliveira Filho, RV; de Oliveira Ilha, J; Moreno, RA; Nahoum, AF; Warnke, A; Wedemeyer, RS1

Reviews

6 review(s) available for promegestone and trimegestone

ArticleYear
Trimegestone: expanding therapeutic choices for the treatment of the menopause.
    Expert opinion on investigational drugs, 2001, Volume: 10, Issue:9

    Topics: Female; Humans; Menopause; Menstrual Cycle; Promegestone

2001
[Pharma-Clinics. Medication of the month. Totelle Cycle: new sequential estrogen/progesterone regimen for hormone replacement therapy in menopause].
    Revue medicale de Liege, 2002, Volume: 57, Issue:6

    Topics: Aged; Estradiol; Female; Hormone Replacement Therapy; Humans; Menopause; Middle Aged; Osteoporosis; Promegestone

2002
The preclinical biology of a new potent and selective progestin: trimegestone.
    Steroids, 2003, Volume: 68, Issue:10-13

    Topics: Animals; Behavior, Animal; Binding, Competitive; Bone and Bones; Dose-Response Relationship, Drug; Humans; Progestins; Promegestone; Protein Binding; Rats; Receptors, Steroid; Time Factors

2003
Clinical experience with trimegestone as a new progestin in HRT.
    Steroids, 2003, Volume: 68, Issue:10-13

    Topics: Adult; Bone Density; Clinical Trials as Topic; Estradiol; Female; Hormone Replacement Therapy; Humans; Menopause; Middle Aged; Postmenopause; Progestins; Promegestone; Time Factors

2003
Sleep apnea and hormone replacement therapy: a pilot study and a literature review.
    Acta obstetricia et gynecologica Scandinavica, 2005, Volume: 84, Issue:1

    Topics: Estradiol; Female; Hormone Replacement Therapy; Humans; Middle Aged; Pilot Projects; Polysomnography; Postmenopause; Promegestone; Sleep Apnea Syndromes

2005
Preclinical and clinical properties of trimegestone: a potent and selective progestin.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2007, Volume: 23, Issue:6

    Topics: Affect; Animals; Body Weight; Central Nervous System; Chemical Phenomena; Chemistry; Depression; Drug Therapy, Combination; Endometrium; Estradiol; Female; gamma-Aminobutyric Acid; Hot Flashes; Humans; Progestins; Promegestone; Receptors, Progesterone; Sleep; Uterine Hemorrhage

2007

Trials

27 trial(s) available for promegestone and trimegestone

ArticleYear
Endometrial effects of three doses of trimegestone, a new orally active progestogen, on the postmenopausal endometrium.
    Maturitas, 1997, Volume: 28, Issue:1

    Topics: Administration, Oral; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Estrogen Replacement Therapy; Female; Humans; Menstrual Cycle; Middle Aged; Pilot Projects; Postmenopause; Promegestone; Prospective Studies

1997
Acceptability and patterns of uterine bleeding in sequential trimegestone-based hormone replacement therapy: a dose-ranging study.
    Human reproduction (Oxford, England), 1999, Volume: 14, Issue:3

    Topics: Aged; Biopsy; Endometrium; Estradiol; Estrogen Replacement Therapy; Female; Humans; Hyperplasia; Middle Aged; Postmenopause; Promegestone; Uterine Hemorrhage

1999
The distribution of endometrial leukocytes and their proliferation markers in trimegestone-treated postmenopausal women compared to the endometrium of the natural cycle: a dose-ranging study.
    Human reproduction (Oxford, England), 1999, Volume: 14, Issue:5

    Topics: Aged; Biomarkers; Cell Division; Discriminant Analysis; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Humans; Immunohistochemistry; Menstrual Cycle; Middle Aged; Postmenopause; Promegestone

1999
Hormone replacement therapy and plasma homocysteine levels.
    Obstetrics and gynecology, 1999, Volume: 94, Issue:4

    Topics: Dydrogesterone; Estradiol; Fasting; Female; Homocysteine; Hormone Replacement Therapy; Humans; Middle Aged; Progesterone Congeners; Promegestone; Prospective Studies; Time Factors

1999
Endometrial histomorphometry of trimegestone-based sequential hormone replacement therapy: a weighted comparison with the endometrium of the natural cycle.
    Human reproduction (Oxford, England), 1999, Volume: 14, Issue:10

    Topics: Aged; Discriminant Analysis; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Hormone Replacement Therapy; Humans; Menstrual Cycle; Middle Aged; Postmenopause; Promegestone

1999
Short-term hormone replacement therapy: reduced plasma levels of soluble adhesion molecules.
    European journal of clinical investigation, 1999, Volume: 29, Issue:11

    Topics: Cholesterol; E-Selectin; Endothelin-1; Endothelium, Vascular; Estradiol; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone; Humans; Intercellular Adhesion Molecule-1; Middle Aged; Nitroglycerin; Placebos; Postmenopause; Progestins; Promegestone; Prospective Studies; Thrombomodulin; Vascular Cell Adhesion Molecule-1; Vasodilation

1999
The effect of submucous fibroids on the dose-dependent modulation of uterine bleeding by trimegestone in postmenopausal women treated with hormone replacement therapy.
    BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:3

    Topics: Dose-Response Relationship, Drug; Endometrium; Female; Hormone Replacement Therapy; Humans; Leiomyoma; Middle Aged; Postmenopause; Progesterone Congeners; Promegestone; Uterine Hemorrhage; Uterine Neoplasms

2000
A study of the adhesive-skin interface: correlation between adhesion and passage of a drug.
    International journal of pharmaceutics, 2000, Apr-25, Volume: 200, Issue:1

    Topics: Adhesiveness; Administration, Cutaneous; Humans; Pharmacokinetics; Polytetrafluoroethylene; Promegestone; Silicone Elastomers; Skin Absorption

2000
Effect of different cyclical sequential progestins on endometrial vascularity in postmenopausal women compared with the natural cycle: a morphometric analysis.
    Human reproduction (Oxford, England), 2000, Volume: 15, Issue:10

    Topics: Adult; Antigens, CD34; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Hormone Replacement Therapy; Humans; Menstrual Cycle; Middle Aged; Norethindrone; Postmenopause; Progestins; Promegestone; Reference Values

2000
A 1-year comparison of the efficacy and clinical tolerance in postmenopausal women of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:5

    Topics: Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Estradiol; Estrogen Replacement Therapy; Female; Hot Flashes; Humans; Middle Aged; Norgestrel; Postmenopause; Progesterone Congeners; Promegestone; Statistics, Nonparametric

2001
Acceptability and patterns of endometrial bleeding in estradiol-based HRT regimens: a comparative study of cyclical sequential combinations of trimegestone or norethisterone acetate.
    Climacteric : the journal of the International Menopause Society, 2001, Volume: 4, Issue:4

    Topics: Argentina; Double-Blind Method; Endometrium; Estradiol; Estrogen Replacement Therapy; Europe; Female; Hot Flashes; Humans; Middle Aged; Norethindrone; Norethindrone Acetate; Patient Satisfaction; Promegestone; Treatment Outcome; Uterine Hemorrhage

2001
Oral oestradiol/trimegestone replacement reduces procarboxypeptidase U (TAFI): a randomized, placebo- controlled, 12-week study in early postmenopausal women.
    Journal of internal medicine, 2002, Volume: 251, Issue:3

    Topics: Carboxypeptidase B2; Estradiol; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Postmenopause; Promegestone; Prospective Studies

2002
The effect of a change in the dose of trimegestone on the pattern of bleeding in estrogen-treated post-menopausal women: 6 month extension of a dose-ranging study.
    Human reproduction (Oxford, England), 2002, Volume: 17, Issue:5

    Topics: Dose-Response Relationship, Drug; Endometrium; Estrogen Replacement Therapy; Female; Humans; Incidence; Medical Records; Middle Aged; Progestins; Promegestone; Severity of Illness Index; Time Factors; Uterine Hemorrhage

2002
Assessment of the metabolic tolerance in postmenopausal women over a 1-year period of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2002, Volume: 16, Issue:2

    Topics: Apolipoprotein A-I; Apolipoproteins B; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Estradiol; Estrogen Replacement Therapy; Female; Fibrinogen; Humans; Lipids; Lipoprotein(a); Lipoproteins, HDL; Lipoproteins, HDL2; Lipoproteins, HDL3; Middle Aged; Norgestrel; Postmenopause; Promegestone

2002
Effects of hormone replacement therapy on blood platelets.
    European journal of clinical investigation, 2002, Volume: 32, Issue:8

    Topics: Antigens, CD; Arteriosclerosis; Biomarkers; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Female; Flow Cytometry; Humans; Middle Aged; P-Selectin; Platelet Activation; Platelet Membrane Glycoproteins; Progesterone Congeners; Promegestone; Prospective Studies; Tetraspanin 30

2002
Increased resistance to activated protein C after short-term oral hormone replacement therapy in healthy post-menopausal women.
    British journal of haematology, 2002, Volume: 119, Issue:4

    Topics: Activated Protein C Resistance; Analysis of Variance; Double-Blind Method; Drug Combinations; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Factor VIII; Factor XI; Female; Humans; Middle Aged; Postmenopause; Promegestone; Prospective Studies

2002
Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Female; Humans; Isomerism; Middle Aged; Progesterone Congeners; Promegestone; Risk Factors; Spectrometry, Fluorescence

2003
Randomized trial of effects of estradiol in combination with either norethisterone acetate or trimegestone on lipids and lipoproteins in postmenopausal women.
    Climacteric : the journal of the International Menopause Society, 2004, Volume: 7, Issue:3

    Topics: Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; England; Estradiol; Estrogen Replacement Therapy; Female; Humans; Lipoprotein(a); Middle Aged; Norethindrone; Norethindrone Acetate; Postmenopause; Promegestone

2004
Efficacy on climacteric symptoms of a continuous combined regimen of 1 mg 17beta-estradiol and trimegestone versus two regimens combining 1 or 2 mg 17beta-estradiol and norethisterone acetate.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2005, Volume: 21, Issue:2

    Topics: Administration, Oral; Adult; Affect; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Estradiol; Estrogen Replacement Therapy; Female; Hot Flashes; Humans; Middle Aged; Norethindrone; Norethindrone Acetate; Postmenopause; Promegestone; Prospective Studies; Quality of Life; Sweating

2005
A study of the control of climacteric symptoms in postmenopausal women following sequential regimens of 1 mg 17beta-estradiol and trimegestone compared with a regimen containing 1 mg estradiol valerate and norethisterone over a two-year period.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2005, Volume: 21, Issue:2

    Topics: Administration, Oral; Adult; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Estradiol; Estrogen Replacement Therapy; Female; Hot Flashes; Humans; Middle Aged; Norethindrone; Norethindrone Acetate; Postmenopause; Promegestone; Prospective Studies; Quality of Life; Sleep Wake Disorders; Sweating; Uterine Hemorrhage

2005
A comparative 2-year study of the effects of sequential regimens of 1 mg 17beta-estradiol and trimegestone with a regimen containing estradiol valerate and norethisterone on the bleeding profile and endometrial safety in postmenopausal women.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2005, Volume: 21, Issue:2

    Topics: Administration, Oral; Adult; Body Weight; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Endometrial Hyperplasia; Endometrium; Estradiol; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Norethindrone; Norethindrone Acetate; Postmenopause; Promegestone; Prospective Studies; Uterine Hemorrhage

2005
Bleeding profile and endometrial safety of continuous combined regimens 1 mg 17beta-estradiol/trimegestone versus 1 or 2 mg 17beta-estradiol/norethisterone acetate in postmenopausal women.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2005, Volume: 21, Issue:3

    Topics: Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Endometrium; Estradiol; Estrogen Replacement Therapy; Europe; Female; Humans; Israel; Menstrual Cycle; Middle Aged; Norethindrone; Norethindrone Acetate; Postmenopause; Promegestone; Treatment Outcome; Uterine Hemorrhage

2005
Inhibitors and activation markers of the haemostatic system during hormone therapy: a comparative study of oral estradiol (2 mg)/ dydrogesterone and estradiol (2 mg)/ trimegestone.
    Thrombosis and haemostasis, 2008, Volume: 100, Issue:2

    Topics: Administration, Oral; Adult; Aged; Blood Coagulation Tests; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Factor V; Female; Fibrinolysis; Hemostasis; Humans; Middle Aged; Progestins; Promegestone; Protein C; Protein S; Risk Factors; Venous Thrombosis

2008
Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone.
    Maturitas, 2009, Mar-20, Volume: 62, Issue:3

    Topics: Adult; Aged; Biomarkers; Blood Coagulation Factors; Cardiovascular Diseases; Double-Blind Method; Drug Therapy, Combination; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Fibrinolysis; Humans; Lipids; Middle Aged; Postmenopause; Progestins; Promegestone; Risk Factors; Thromboembolism; Uterine Hemorrhage

2009
A randomized, controlled pilot trial of hormone therapy for menopausal insomnia.
    Archives of women's mental health, 2011, Volume: 14, Issue:6

    Topics: Adult; Double-Blind Method; Estradiol; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Perimenopause; Pilot Projects; Polysomnography; Promegestone; Sleep; Sleep Initiation and Maintenance Disorders; Treatment Outcome

2011
Ovulation inhibition with a new vaginal ring containing trimegestone.
    Contraception, 2020, Volume: 102, Issue:4

    Topics: Adult; Contraceptive Devices, Female; Estradiol; Female; Follicle Stimulating Hormone; Humans; Ovulation; Ovulation Inhibition; Progesterone; Promegestone

2020
Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential.
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2021, Volume: 26, Issue:3

    Topics: Administration, Intravaginal; Adult; Chromatography, Liquid; Contraceptive Agents, Female; Contraceptive Devices, Female; Estradiol; Estriol; Estrogens; Female; Humans; Progesterone; Promegestone; Tandem Mass Spectrometry

2021

Other Studies

16 other study(ies) available for promegestone and trimegestone

ArticleYear
Properties of progestin-binding protein in benign hypertrophic human prostate.
    Endocrinologia japonica, 1986, Volume: 33, Issue:3

    Topics: Alpha-Globulins; Binding, Competitive; Cytosol; Estrenes; Humans; Kinetics; Male; Metribolone; Norpregnadienes; Progesterone Congeners; Progesterone-Binding Globulin; Promegestone; Prostate; Prostatic Hyperplasia; Steroids

1986
Evaluation of RU-27987 as a ligand to determine the progesterone receptor.
    Clinica chimica acta; international journal of clinical chemistry, 1987, Sep-15, Volume: 168, Issue:1

    Topics: Breast Neoplasms; Cytosol; Dexamethasone; Humans; Kinetics; Ligands; Norpregnadienes; Promegestone; Receptors, Glucocorticoid; Receptors, Progesterone; Thymus Gland

1987
Trimegestone. RU 27987.
    Drugs in R&D, 1999, Volume: 1, Issue:3

    Topics: Aged; Drugs, Investigational; Female; Humans; Middle Aged; Osteoporosis; Osteoporosis, Postmenopausal; Progestins; Promegestone

1999
The pharmacological profile of a novel norpregnance progestin (trimegestone).
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13, Issue:5

    Topics: Administration, Oral; Administration, Topical; Animals; Binding, Competitive; Endometrium; Female; Humans; Injections, Subcutaneous; Levonorgestrel; Medroxyprogesterone; Mice; Norethindrone; Norpregnenes; Progesterone Congeners; Promegestone; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Progesterone; Specific Pathogen-Free Organisms; Uterus

1999
Microbial models of drug metabolism: microbial transformations of Trimegestone (RU27987), a 3-keto-delta(4,9(10))-19-norsteroid drug.
    Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:11

    Topics: Biotransformation; Female; Fungi; Humans; Promegestone; Streptomyces; Time Factors

1999
Physical evaluation of a new patch made of a progestomimetic in a silicone matrix.
    International journal of pharmaceutics, 2000, Apr-10, Volume: 199, Issue:1

    Topics: Adhesiveness; Adhesives; Administration, Cutaneous; Adult; Female; Humans; In Vitro Techniques; Promegestone; Rheology; Silicones; Surface Properties

2000
Residues in the ligand binding domain that confer progestin or glucocorticoid specificity and modulate the receptor transactivation capacity.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:7

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Furylfuramide; Glucocorticoids; Hormone Antagonists; Humans; Hydroxycorticosteroids; Mifepristone; Models, Molecular; Molecular Sequence Data; Progestins; Promegestone; Protein Conformation; Receptors, Glucocorticoid; Receptors, Progesterone; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transcriptional Activation

2000
Effect of trimegestone alone or in combination with estradiol on bone mass and bone turnover in an adult rat model of osteopenia.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:1

    Topics: Administration, Oral; Animals; Bone Density; Bone Diseases, Metabolic; Disease Models, Animal; Estradiol; Female; Injections, Subcutaneous; Promegestone; Rats; Rats, Sprague-Dawley

2001
Effects of 17 beta-estradiol and trimegestone alone, and in combination, on the bone and uterus of ovariectomized rats.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:4

    Topics: Animals; Bone and Bones; Bone Density; Disease Models, Animal; Drug Administration Schedule; Estradiol; Female; Hormone Replacement Therapy; Humans; Osteoporosis, Postmenopausal; Ovariectomy; Promegestone; Rats; Rats, Sprague-Dawley; Uterus

2001
Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 78, Issue:2

    Topics: Animals; Biological Assay; Complement C3; Dose-Response Relationship, Drug; Estrogen Receptor Modulators; Female; Medroxyprogesterone; Progesterone Congeners; Progestins; Promegestone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; RNA, Messenger; Uterus

2001
Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 94, Issue:4

    Topics: Androstenes; Animals; Antithrombins; Blood Coagulation; Cholesterol; Estrogens; Ethinyl Estradiol; Female; Humans; Lipoproteins; Models, Animal; Norethindrone; Norethindrone Acetate; Norethynodrel; Ovariectomy; Progestins; Promegestone; Rats; Rats, Sprague-Dawley

2005
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.
    The Journal of biological chemistry, 2005, Aug-05, Volume: 280, Issue:31

    Topics: Alkaline Phosphatase; Amino Acid Substitution; Benzoxazines; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Humans; Ligands; Mutagenesis, Site-Directed; Promegestone; Pyrroles; Receptors, Progesterone; Recombinant Proteins; X-Ray Diffraction

2005
Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 97, Issue:4

    Topics: Alkaline Phosphatase; Androstenes; Breast Neoplasms; Cell Line, Tumor; Cluster Analysis; Desogestrel; Dose-Response Relationship, Drug; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Levonorgestrel; Ligands; Medroxyprogesterone Acetate; Oligonucleotide Array Sequence Analysis; Progesterone; Progestins; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transcription, Genetic

2005
Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell.
    Molecular human reproduction, 2006, Volume: 12, Issue:3

    Topics: Adult; Cells, Cultured; Dose-Response Relationship, Drug; Endometrium; Estradiol; Female; Humans; Immunohistochemistry; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Menstruation; Middle Aged; Mifepristone; Progesterone; Progestins; Promegestone; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells

2006
Parallel assessment of the impact of different hormone replacement therapies on breast density by radiologist- and computer-based analyses of mammograms.
    Climacteric : the journal of the International Menopause Society, 2008, Volume: 11, Issue:2

    Topics: Administration, Intranasal; Administration, Oral; Aged; Breast; Dose-Response Relationship, Drug; Estradiol; Estrogens; Female; Hormone Replacement Therapy; Humans; Mammography; Middle Aged; Postmenopause; Progesterone; Progestins; Promegestone; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors

2008
[Effect of trimegestone on mammary gland of castrated rats].
    Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2011, Volume: 33, Issue:7

    Topics: Animals; Cell Proliferation; Female; Mammary Glands, Animal; Ovariectomy; Promegestone; Rats; Rats, Wistar

2011