Page last updated: 2024-08-16

promazine and desipramine

promazine has been researched along with desipramine in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (36.62)	18.7374
1990's	2 (2.82)	18.2507
2000's	12 (16.90)	29.6817
2010's	29 (40.85)	24.3611
2020's	2 (2.82)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Chiang, GH; Unger, SH	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Duffy, EM; Jorgensen, WL	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M	1
Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI	1
Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Glen, RC; Lowe, R; Mitchell, JB	1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M	1
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM	1
Brea, J; Cadavid, MI; Campillo, NE; Ceballos, P; Gil, C; Loza, MI; Martínez, A; Moro, MA; Pérez, C; Pérez, DI; Perez-Castillo, A; Redondo, M; Val, C; Zarruk, JG	1
Andrisano, V; Bolognesi, ML; Carloni, P; Cavalli, A; Chiriano, G; De Simone, A; Legname, G; Mancini, F; Martinez, A; Perez, DI; Roberti, M	1
Alonso-Gil, S; Campillo, NE; Castro, A; Encinas, A; Gil, C; Martinez, A; Morales-Garcia, JA; Palomo, V; Perez, C; Perez, DI; Perez-Castillo, A; Soteras, I	1
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM	1
Alonso-Gil, S; Chavarría, C; Gil, C; Morales Garcia, JA; Pérez, C; Perez, DI; Pérez-Castillo, A; Porcal, W; Souza, JM	1
Chen, J; Chen, X; Huang, L; Li, X; Sun, Y	1
Bellman, K; Knegtel, RM; Settimo, L	1
Andrisano, V; Bartolini, M; Clos, MV; Di Pietro, O; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Ramón, R; Viayna, E; Vicente-García, E	1
Bello, ML; Gil, C; Kraemer, BC; Lecourtois, M; Liachko, NF; Martinez, A; Miguel, L; Perez, C; Perez, DI; Redondo, M; Salado, IG	1
Clos, MV; Di Pietro, O; Espargaró, A; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sabaté, R	1
Clos, MV; Di Pietro, O; Espargaró, A; Galdeano, C; Guillou, C; Lamuela-Raventós, RM; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Ragusa, IM; Sabaté, R; Vallverdú-Queralt, A; Viayna, E	1
Huang, L; Li, X; Meng, F; Miao, H; Sun, Y	1
Artigas, A; Clos, MV; Gbedema, SY; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Wright, CW	1
Cahlíková, L; Chlebek, J; Hošt'álková, A; Opletal, L; Pérez, DI; Šafratová, M; Štěpánková, Š	1
Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E	1
Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E	1
Artigas, A; Clos, MV; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sola, I; Taylor, MC; Viayna, E; Wright, CW	1
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S	1
Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL	1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Campillo, NE; Geiger, L; Gil, C; González, S; Li, L; Martinez, A; Morales, AV; Perez, DI; Salado, IG; Sebastián-Pérez, V; Zaldivar-Diez, J	1
Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V	1
Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N	1
Alcaro, S; Bagetta, D; Borges, F; Cagide, F; Oliveira, PJ; Ortuso, F; Pérez, C; Reis, J; Rodríguez-Franco, MI; Teixeira, J; Uriarte, E; Valencia, ME	1
An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T	1
Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S	1
Chaikuad, A; de Lago, E; Gil, C; Gomez-Almeria, M; Gonzalo-Consuegra, C; Knapp, S; Lietha, D; Martín-Requero, A; Martinez, A; Martínez-González, L; Monti, B; Nozal, V; Palomo, V; Pérez-Cuevas, E; Petralla, S; Ramírez, D; Santana, P	1
Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S	1
Løvstad, RA	1
Claeys, M; Maenhaut, W; Markey, SP	1
Belvedere, G; Burti, L; Frigerio, A; Pantarotto, C	1
Orthen-Gambill, N; Salomon, M	1
Frisk-Holmberg, M; van der Kleijn, E	1
Tuomisto, J	1
Glasser, H; Krieglstein, J	1
Krieglstein, J; Rieger, H; Stock, R	1
Gyermek, L; Hill, RT; Sigg, EB	1
Colson, SH; Tolson, WW; Umberger, EJ	1
Clark, B; Thompson, JW; Widdrington, G	1
Krieglstein, J; Rieger, H	1
Lee, RE	1
Mainard, F; Stephan, Y; Welin, L	1
Maickel, RP; Sokol, GH	1
Iriye, TT; Simmonds, FA	2
Oates, JA; Shand, DG	1
Gross, R; Linker, H; Reuter, H	1
Anton-Tay, F; Axelrod, J; Wurtman, RJ	1
Beierle, FA; Hubbard, RW	1
Ballesta, J; de la Torre, R; González, S; Ortuño, J; Pascual, JA	1
GYERMEK, L; SIGG, EB; SOFFER, L	1
BOFF, E; SCHECKEL, CL	1
LUDDEN, CT; PORTER, CC; STAVORSKI, JM; STONE, CA; TOTARO, JA	1
HALLIWELL, G; QUINTON, RM; WILLIAMS, FE	1

Other Studies

71 other study(ies) available for promazine and desipramine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine	2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine	2009
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry, 2011, Volume: 46, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine	2011
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. European journal of medicinal chemistry, 2012, Volume: 47, Issue:1 Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Permeability; Quinazolines; Stroke	2012
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. European journal of medicinal chemistry, 2012, Volume: 48 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cell Survival; Chickens; Humans; Imidazoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Neurons; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship	2012
5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3. Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blood-Brain Barrier; Cell Death; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Glycogen Synthase Kinase 3; Hippocampus; Humans; Imines; In Vitro Techniques; Lipopolysaccharides; Membranes, Artificial; Microglia; Models, Molecular; Neural Stem Cells; Neurogenesis; Neurons; Neuroprotective Agents; Nitrites; Protein Binding; Rats; Structure-Activity Relationship; Substrate Specificity; Swine; Thiadiazoles	2012
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding	2012
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. European journal of medicinal chemistry, 2012, Volume: 58 Topics: Anti-Inflammatory Agents; Antioxidants; Blood-Brain Barrier; Cell Survival; Dose-Response Relationship, Drug; Humans; Microwaves; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Peroxynitrous Acid; Structure-Activity Relationship; Tyrosine	2012
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. European journal of medicinal chemistry, 2014, Feb-12, Volume: 73 Topics: Acetylcholinesterase; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Membranes, Artificial; Models, Biological; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Naphthyridines; Permeability; Protein Binding	2014
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Casein Kinase I; Cell Membrane Permeability; Cells, Cultured; DNA-Binding Proteins; Drosophila; Drug Design; Drug Discovery; HEK293 Cells; Heterocyclic Compounds; High-Throughput Screening Assays; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neurons; Neurotoxicity Syndromes; Phosphorylation; Protein Kinase Inhibitors; Substrate Specificity	2014
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies. European journal of medicinal chemistry, 2014, Sep-12, Volume: 84 Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tacrine; tau Proteins; Tauopathies	2014
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties. Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19 Topics: Acetylcholinesterase; Aminoquinolines; Amyloid beta-Peptides; Antioxidants; Catechols; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; tau Proteins	2014
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease. European journal of medicinal chemistry, 2014, Nov-24, Volume: 87 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates	2014
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & medicinal chemistry letters, 2014, Dec-01, Volume: 24, Issue:23 Topics: Antimalarials; Antiprotozoal Agents; Humans; Molecular Structure; Structure-Activity Relationship	2014
In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier. Journal of natural products, 2015, Jun-26, Volume: 78, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amaryllidaceae Alkaloids; Biological Transport; Blood-Brain Barrier; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Molecular Structure	2015
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. European journal of medicinal chemistry, 2015, Nov-13, Volume: 105 Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi	2015
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors. Bioorganic & medicinal chemistry, 2016, 10-15, Volume: 24, Issue:20 Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship	2016
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorganic & medicinal chemistry, 2016, 11-01, Volume: 24, Issue:21 Topics: Aminoquinolines; Brain; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2016
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured	2016
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species	2017
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques	2017
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Animals; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Indoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Neural Stem Cells; Neuroprotective Agents; Protein Kinase Inhibitors; Structure-Activity Relationship	2017
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. European journal of medicinal chemistry, 2018, Feb-10, Volume: 145 Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship	2018
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease. European journal of medicinal chemistry, 2018, Apr-25, Volume: 150 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine	2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors. European journal of medicinal chemistry, 2018, Oct-05, Volume: 158 Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Targeted Therapy; Monoamine Oxidase; Monoamine Oxidase Inhibitors	2018
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Feb-01, Volume: 163 Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram	2019
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine	2019
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Case-Control Studies; DNA-Binding Proteins; Humans; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Spinal Cord; Tissue Distribution	2022
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. European journal of medicinal chemistry, 2022, Jun-05, Volume: 236 Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate	2022
Effect of centrally active drugs on dopamine oxidation by rat brain catecholamine oxidase. Experientia, 1979, Dec-15, Volume: 35, Issue:12 Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Desipramine; Dopamine; Dopamine beta-Hydroxylase; Female; Haloperidol; Imipramine; Kinetics; Promazine; Rats; Thioridazine; Trifluoperazine; Trifluperidol	1979
Variance analysis of error in selected ion monitoring assays using various internal standards. A practical study case. Biomedical mass spectrometry, 1977, Volume: 4, Issue:2 Topics: Analysis of Variance; Chromatography, Gas; Desipramine; Imipramine; Maprotiline; Mass Spectrometry; Methods; Promazine; Regression Analysis; Time Factors	1977
Gas chromatographic-mass fragmentographic determation of "steady-state" plasma levels of imipramine and desipramine in chronically treated patients. Journal of chromatography, 1975, Sep-03, Volume: 111, Issue:2 Topics: Chromatography, Gas; Depression; Desipramine; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Middle Aged; Promazine	1975
Differential effects of psychotropic drugs on feeding in rats: is histamine blockade involved? Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4 Topics: Animals; Desipramine; Diet; Doxepin; Drinking; Eating; Haloperidol; Histamine Antagonists; Male; Promazine; Psychotropic Drugs; Rats; Rats, Inbred Strains	1990
The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release. European journal of pharmacology, 1972, Volume: 18, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Clopenthixol; Desipramine; Fluphenazine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; Methotrimeprazine; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Rats; Solvents; Structure-Activity Relationship; Thioridazine; Tranquilizing Agents; Trifluoperazine	1972
A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors. The Journal of pharmacy and pharmacology, 1974, Volume: 26, Issue:2 Topics: Amitriptyline; Animals; Blood Platelets; Carbon Radioisotopes; Chlorpromazine; Desipramine; Dibenzazepines; Doxepin; Imipramine; In Vitro Techniques; Kinetics; Models, Biological; Nortriptyline; Promazine; Rabbits; Serotonin; Synaptosomes; Temperature; Trifluoperazine; Triflupromazine	1974
[Protein binding of some psychoactive drugs with a tricyclic ring system, as a function of their chemical constitution]. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 265, Issue:4 Topics: Acepromazine; Alcohols; Amitriptyline; Chemical Phenomena; Chemistry, Physical; Chlorpromazine; Chromatography, Gel; Desipramine; Dialysis; Dibenzazepines; Dibenzocycloheptenes; Imipramine; Phenothiazines; Promazine; Protein Binding; Serum Albumin, Bovine; Thiazines; Triflupromazine	1970
Influence of therapeutic and toxic doses of neuroleptics and antidepressants on energy metabolism of the isolated perfused rat brain. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 279, Issue:3 Topics: Acetone; Ammonia; Animals; Antidepressive Agents; Brain; Creatine; Desipramine; Dose-Response Relationship, Drug; Electroencephalography; Energy Metabolism; Fructosephosphates; Glucose; Glucosephosphates; Glycolysis; Imipramine; Ketoglutaric Acids; Lactates; Male; Organophosphorus Compounds; Perfusion; Phosphocreatine; Promazine; Pyruvates; Rats; Ribonucleotides; Tranquilizing Agents; Trioses	1973
Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents. Psychopharmacologia, 1965, Feb-15, Volume: 7, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Behavior, Animal; Cyproheptadine; Desipramine; Diphenhydramine; Hallucinogens; Histamine H1 Antagonists; Imipramine; Lysergic Acid Diethylamide; Mice; Promazine; Psychopharmacology; Reserpine; Serotonin	1965
The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase. Life sciences, 1969, Nov-15, Volume: 8, Issue:22 Topics: Adrenalectomy; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Desipramine; Diphenhydramine; Enzyme Induction; Female; Fluocinolone Acetonide; Fluorometholone; Glucocorticoids; Hydrocortisone; Imipramine; Liver; Male; Prednisone; Proadifen; Promazine; Promethazine; Rats; Reserpine; Sex Factors; Triflupromazine; Tyrosine Transaminase	1969
Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man. British journal of pharmacology, 1972, Volume: 44, Issue:1 Topics: Amphetamine; Animals; Chlorpromazine; Desipramine; Drug Interactions; Histamine; Hydrazines; Hydrocortisone; Imipramine; Iproniazid; Male; Meperidine; Methylation; Microsomes, Liver; Monoamine Oxidase Inhibitors; Nialamide; Opipramol; Phenothiazines; Phenylhydrazines; Prednisolone; Proadifen; Promazine; Rats; Transferases	1972
Quantitative analysis of the EEG effects produced by imipramine, desipramine promazine, and monodesmethyl promazine in the isolated perfused rat brain. Psychopharmacologia, 1974, Volume: 39, Issue:2 Topics: Analysis of Variance; Animals; Brain; Desipramine; Electroencephalography; Imipramine; In Vitro Techniques; Male; Perfusion; Promazine; Rats	1974
The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins, 1974, Jan-10, Volume: 5, Issue:1 Topics: Animals; Antidepressive Agents; Aspirin; Carbon Radioisotopes; Cell-Free System; Chlorpromazine; Chromatography, Thin Layer; Depression, Chemical; Desipramine; Doxepin; Guinea Pigs; Indomethacin; Lung; Methods; Pargyline; Phenelzine; Promazine; Prostaglandins; Tranylcypromine	1974
[Binding to human serum proteins of drugs belonging to phenothiazine series, iminodibenzyle, thioxanthene and thiophenylpyridylamine]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1971, Mar-08, Volume: 272, Issue:10 Topics: Antidepressive Agents; Blood Proteins; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Chromatography, Gel; Desipramine; Dibenzazepines; Humans; Imipramine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Protein Binding; Spectrophotometry; Thiazines; Trimeprazine	1971
Toxic interactions of d-amphetamine and tricyclic antidepressants in mice. Research communications in chemical pathology and pharmacology, 1972, Volume: 3, Issue:3 Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Drug Antagonism; Drug Interactions; Drug Synergism; Imipramine; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nortriptyline; Promazine; Time Factors	1972
Effect of tranquilizers and antidepressants on glycogen phosphorylase of rat brain. Biochemical pharmacology, 1971, Volume: 20, Issue:8 Topics: Adenosine Monophosphate; Animals; Antidepressive Agents; Brain; Depression, Chemical; Desipramine; Dextroamphetamine; Female; Freezing; Glucosyltransferases; Iproniazid; Norepinephrine; Pargyline; Perphenazine; Phosphorylases; Prochlorperazine; Promazine; Promethazine; Rats; Receptors, Adrenergic; Reserpine; Tranquilizing Agents; Triflupromazine	1971
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs. Biochemical pharmacology, 1971, Volume: 20, Issue:7 Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine	1971
Possible involvement of glycogen phosphorylase of brain in the affective states. International pharmacopsychiatry, 1971, Volume: 6, Issue:2 Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Chlorpromazine; Depression; Desipramine; Drug Interactions; Female; Humans; Iproniazid; Pargyline; Phenothiazines; Phosphorylases; Prochlorperazine; Promazine; Promethazine; Rats; Receptors, Adrenergic; Reserpine; Stereoisomerism; Tranquilizing Agents	1971
[A possible mechanism of disaggregation of ADP-induced aggregates by imipramin and structurally related compouds]. Thrombosis et diathesis haemorrhagica, 1969, Nov-15, Volume: 22, Issue:2 Topics: Adenine Nucleotides; Amitriptyline; Blood Platelets; Chlorpromazine; Desipramine; Diphenhydramine; Humans; Imipramine; Nortriptyline; Optical Rotatory Dispersion; Platelet Adhesiveness; Promazine; Promethazine	1969
Inhibition of the metabolism of H3-melatonin by phenothiazines. The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:2 Topics: Amphetamine; Animals; Antimetabolites; Body Temperature; Brain; Chlorpromazine; Depression, Chemical; Desipramine; Female; Imipramine; Liver; Melatonin; Phenobarbital; Phenothiazines; Promazine; Promethazine; Rats; Tritium	1968
Liquid chromatographic separation of antidepressant drugs: I. Tricyclics. Therapeutic drug monitoring, 1983, Volume: 5, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Promazine; Protriptyline	1983
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection. Therapeutic drug monitoring, 1998, Volume: 20, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Drug Monitoring; Humans; Imipramine; Linear Models; Nortriptyline; Promazine; Sensitivity and Specificity	1998
INFLUENCE OF IMIPRAMINE AND RELATED PSYCHOACTIVE AGENTS ON THE EFFECT OF 5-HYDROXYTRYPTAMINE AND CATECHOLAMINES ON THE CAT NICTITATING MEMBRANE. The Journal of pharmacology and experimental therapeutics, 1963, Volume: 142 Topics: Amitriptyline; Animals; Antidepressive Agents; Catecholamines; Cats; Chlorpromazine; Chlorprothixene; Desipramine; Epinephrine; Imipramine; Nictitating Membrane; Norepinephrine; Pharmacology; Promazine; Psychotropic Drugs; Research; Serotonin; Tranquilizing Agents	1963
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE. Psychopharmacologia, 1964, Feb-12, Volume: 5 Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine	1964
ANTAGONISM OF CERTAIN EFFECTS OF CATECHOLAMINE-DEPLETING AGENTS BY ANTIDEPRESSANT AND RELATED DRUGS. The Journal of pharmacology and experimental therapeutics, 1964, Volume: 144 Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dogs; Dopamine; Electric Stimulation; Electrophysiology; Guanethidine; Imipramine; Metaraminol; Methylphenidate; Mice; Myocardium; Nictitating Membrane; Norepinephrine; Pharmacology; Piperidines; Promazine; Research; Reserpine; Tripelennamine; Tyrosine	1964
A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE. British journal of pharmacology and chemotherapy, 1964, Volume: 23 Topics: Alcoholic Intoxication; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Autonomic Nervous System; Bradycardia; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Desipramine; Dogs; Epinephrine; Imipramine; Mice; Norepinephrine; Pharmacology; Promazine; Rats; Research; Reserpine; Sleep; Toxicology; Tranquilizing Agents; Vasomotor System; Yohimbine	1964