prolylleucine has been researched along with naloxone in 4 studies
| Studies (prolylleucine) | Trials (prolylleucine) | Recent Studies (post-2010) (prolylleucine) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 24 | 0 | 6 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | prolylleucine (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhargava, HN; Flexner, LB; Krivoy, WA; Rainbow, TC; Ritzmann, RF; Walter, R | 1 |
| Baláspiri, L; Kovács, GL; Szontágh, L; Telegdy, G | 1 |
| Barnett, A; Chipkin, RE; Iorio, LC; Latranyi, M | 1 |
| Baláspiri, L; Bohus, P; Hódi, K; Kovács, GL; Szontágh, L; Telegdy, G | 1 |
4 other study(ies) available for prolylleucine and naloxone
| Article | Year |
|---|---|
Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.
Topics: Animals; Body Temperature Regulation; Body Weight; Dipeptides; Drug Tolerance; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Retention, Psychology | 1978 |
Dipeptides delay the onset of morphine withdrawal in the mouse.
Topics: Analysis of Variance; Animals; Dipeptides; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pyrrolidonecarboxylic Acid; Substance Withdrawal Syndrome | 1984 |
Direct analgesic effects of Z-prolyl-d-leucine and Z-prolyl-L-leucine in the rat yeast-paw test.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Drug Tolerance; Hypophysectomy; Kinetics; Latency Period, Psychological; Male; Mice; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Saimiri; Yeasts | 1983 |
On the mode of action of an oxytocin derivative (Z-Pro-D-Leu) on morphine-dependence in mice.
Topics: Animals; Biogenic Amines; Brain Chemistry; Dipeptides; Humans; Injections, Intraventricular; Male; Mice; Morphine Dependence; Naloxone; Pain; Substance Withdrawal Syndrome | 1981 |