prolylleucine has been researched along with morphine in 7 studies
| Studies (prolylleucine) | Trials (prolylleucine) | Recent Studies (post-2010) (prolylleucine) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 24 | 0 | 6 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | prolylleucine (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhargava, HN; Flexner, LB; Krivoy, WA; Rainbow, TC; Ritzmann, RF; Walter, R | 1 |
| Faludi, M; Horváth, Z; Kovács, GL; Sarnyai, Z; Telegdy, G | 1 |
| Barth, T; Brtnik, F; Izbéki, F; Jost, K; Kovács, GL; Sarnyai, Z; Szabó, G; Telegdy, G | 1 |
| Baláspiri, L; Kovács, GL; Szontágh, L; Telegdy, G | 1 |
| Hódi, K; Kovács, GL; Telegdy, G | 1 |
| Horváth, Z; Izbéki, F; Kovács, GL; Telegdy, G | 1 |
| Barnett, A; Chipkin, RE; Iorio, LC; Latranyi, M | 1 |
7 other study(ies) available for prolylleucine and morphine
| Article | Year |
|---|---|
Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.
Topics: Animals; Body Temperature Regulation; Body Weight; Dipeptides; Drug Tolerance; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Retention, Psychology | 1978 |
Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain.
Topics: Animals; Brain; Dipeptides; Dopamine; Drug Interactions; Drug Tolerance; Humans; Male; Mice; Morphine; Morphine Dependence; Oxytocin; Synaptic Transmission | 1985 |
Effects of oxytocin-related peptides on acute morphine tolerance: opposite actions by oxytocin and its receptor antagonists.
Topics: Analgesia; Animals; Brain; Dipeptides; Drug Interactions; Drug Tolerance; Injections, Intraventricular; Lypressin; Male; Mice; Morphine; Oxytocin; Pain; Receptors, Angiotensin; Receptors, Oxytocin | 1987 |
Dipeptides delay the onset of morphine withdrawal in the mouse.
Topics: Analysis of Variance; Animals; Dipeptides; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pyrrolidonecarboxylic Acid; Substance Withdrawal Syndrome | 1984 |
Drugs affecting brain dopamine interfere with the effect of Z-prolyl-D-leucine on morphine withdrawal.
Topics: alpha-Methyltyrosine; Animals; Brain Chemistry; Dipeptides; Dopamine; Humans; Male; Methyltyrosines; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Receptors, Dopamine; Serotonin; Substance Withdrawal Syndrome | 1984 |
Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system.
Topics: Animals; Dipeptides; Drug Tolerance; Humans; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Oxytocin; Substance Withdrawal Syndrome | 1984 |
Direct analgesic effects of Z-prolyl-d-leucine and Z-prolyl-L-leucine in the rat yeast-paw test.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Drug Tolerance; Hypophysectomy; Kinetics; Latency Period, Psychological; Male; Mice; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Saimiri; Yeasts | 1983 |