prolylglycine and prolyl-glycyl-proline

Our own data and data from the literature on the regulatory role of the simplest proline-containing peptides GP, PG, PGP, GPGG, and cyclic-PG are summarized. These peptides are involved in homeostasis of gastric mucosa and the anticoagulant and fibrinolytic potential of blood plasma. They also potentiate memory consolidation processes in the central nervous system. The most probable sources of these peptides are polypeptide precursors of collagen, elastin, and enterostatin.

Topics: Animals; Blood Coagulation; Dipeptides; Fibrinolysis; Gastric Mucosa; Homeostasis; Humans; Memory; Oligopeptides; Proline

Topics: Administration, Intranasal; Administration, Intravenous; Animals; Area Under Curve; Blood; Blood Chemical Analysis; Brain; Central Nervous System Agents; Dipeptides; Male; Oligopeptides; Proline; Proteolysis; Rats, Wistar; Time Factors

Intranasal administration of Semax, peptide Pro-Gly-Pro, and a mixture of peptides Pro-Gly+Gly-Pro to rats for 5 days enhanced anticoagulant and fibrinolytic potential of the plasma (total fibrinolytic activity and plasmin and plasminogen activator activities) and decreased antiplasmin concentration. Semax and Pro-Gly-Pro decreased the weight of thrombi during experimental thrombosis.

Topics: Adrenocorticotropic Hormone; Animals; Anticoagulants; Blood Coagulation; Dipeptides; Fibrinolysin; Fibrinolysis; Fibrinolytic Agents; Humans; Male; Oligopeptides; Peptide Fragments; Proline; Rats

Intraperitoneal administration of the PGP did not change basal mucosal blood flow, whereas the PG and GP significantly decreased it. Ethanol and Indomethacin caused a rapid and stable decrease in the blood flow. Administration of the PGP prior to ethanol abolished this effect. Injections of the PGP and PG following Indomethacin administration prevented reduction of the mucosal blood flow. Administration of the GP did not change the blood flow decrease induced with Indomethacin. The mucosal blood flow correction seems to be one of the possible mechanisms of the PGP and PG antiulcer effect. The effect seems to be realised through a change in the CNS activity.

Topics: Animals; Anti-Ulcer Agents; Dipeptides; Ethanol; Gastric Mucosa; Indomethacin; Male; Oligopeptides; Proline; Rats; Regional Blood Flow

Topics: Animals; Blood Coagulation; Dipeptides; Homeostasis; In Vitro Techniques; Injections, Intravenous; Male; Oligopeptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Proline; Rats