proline has been researched along with thiazoles in 172 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (11.63) | 18.7374 |
| 1990's | 12 (6.98) | 18.2507 |
| 2000's | 45 (26.16) | 29.6817 |
| 2010's | 90 (52.33) | 24.3611 |
| 2020's | 5 (2.91) | 2.80 |
| Authors | Studies |
|---|---|
| Fazakerley, GV; Jackson, GE | 1 |
| Deutsch, HF; Fett, JW | 1 |
| Benedetti, E; Christensen, A; Fuller, W; Gilon, C; Goodman, M | 1 |
| Arakawa, N; Otsuka, M; Sakashita, Y; Tsuda, M | 1 |
| Lopez, RA; Slomiany, A; Slomiany, BL | 1 |
| Deutch, CE | 1 |
| Bean, J; Eggleston, D; Kopple, K; Regoli, D; Romoff, T; Samanen, J; Saunders, M; Zuber, G | 1 |
| Kovacic, P; Popp, WJ; Ryan, MD; Timberlake, JW | 1 |
| Hara, H; Kurashima, Y; Miwa, M; Shinohara, K; Tanaka, Y; Tsuda, M | 1 |
| Cho, T; Hagihara, Y; Hayashi, S; Kaminishi, H; Tsuno, N | 1 |
| Reimer, AA | 1 |
| Bublitz, C | 1 |
| Fairweather, R; Jones, JH | 1 |
| Kuznar, J; Magaña-Schwencke, N; Schwencke, J | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Liberti, JP; Rogers, KS | 1 |
| Halpern, B; Westley, JW | 1 |
| Burdett, K; Elder, JB; Reed, PI; Smith, PL; Walters, CL | 1 |
| Giesen, EM; Imbs, JL; Schmidt, M; Schwartz, J | 1 |
| Bartsch, H; Crespi, M; Friesen, M; Lu, SH; Muñoz, N; O'Neill, I; Ohshima, H; Pignatelli, B | 1 |
| Díaz Gil, JJ; Trilla, C | 1 |
| Beames, DJ; Campbell, AJ; Edwards, SR; Montague, PE; Moore, RJ; Sheers, M | 1 |
| Kolodziej, SA; Lignon, MF; Marshall, GR; Martinez, J; Nikiforovich, GV; Skeean, R | 1 |
| Iinuma, H; Naganawa, H; Shimanaka, K; Takahashi, Y; Takeuchi, T | 1 |
| Radomski, J; Wróbel, M; Włodek, L | 1 |
| Liau, YH; Lopez, RA; Slomiany, A; Slomiany, BL | 1 |
| Cutler, KO; Deutch, CE; Reese, LM | 1 |
| Filippi, C; Keriel, C; Leverve, X; Nogueira, V; Ronot, X; Sibille, B | 1 |
| Chang, MC; Hahn, LJ; Hsieh, CC; Jeng, JH; Kuo, MY; Lin, SK | 1 |
| Chan, CP; Chang, MC; Hsieh, CC; Jeng, JH; Lan, WC; Lan, WH | 1 |
| Conway, KA; Harper, JD; Lansbury, PT | 1 |
| Damas, AM; Merlini, G; Saraiva, MJ; Sebastião, MP | 1 |
| Demuth, H; Mrestani-Klaus, C; Neubert, K; Stiebitz, B; Stöckel-Maschek, A | 1 |
| Goetz, GH; Harrigan, GG; Likos, J; Luesch, H; Yang, S | 1 |
| Boissard, C; Chung, NN; Keller, M; Lemieux, C; Mutter, M; Patiny, L; Schiller, PW | 1 |
| Corboy, MJ; Cutler, TD; Hunt, JF; Lee, MG; Oldan, J; Rizo, J; Thibodeau, PH; Thomas, PJ; Wigley, WC | 1 |
| Arasappan, A; Chen, KX; Girijavallabhan, V; Njoroge, FG; Parekh, TN | 1 |
| Aksenova, M; Butterfield, DA; Kanski, J; Schöneich, C | 1 |
| Beattie, DS; Fang, J | 1 |
| Blüher, M; Lübben, G; Paschke, R | 1 |
| Cai, G; Ma, D; Wei, J; Zou, B | 1 |
| LALLIER, R | 1 |
| BAVETTA, LA; BEKHOR, IJ; MOHSENI, Z | 1 |
| Akaike, T; Fang, J; Greish, K; Maeda, H; Sawa, T | 1 |
| Carretero, OA; Cavasin, MA; Rhaleb, NE; Yang, XP | 1 |
| Hahm, KS; Lee, DG; Shin, SY | 1 |
| Chierici, S; Dumy, P; Figuet, M; Jourdan, M | 1 |
| Abedini, A; Raleigh, DP | 1 |
| Bokoch, GM; Cheng, JQ; Kaneko, S; Kim, D; Kruh, GD; Nicosia, SV; Sussman, M; Testa, JR; Yuan, ZQ | 1 |
| Koelsch, R; Neubert, K; Stiebitz, B; Stöckel-Maschek, A | 1 |
| Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, N | 1 |
| Barberis, C; Mutter, M; Patiny, L; Slaninova, J; Wittelsberger, A | 1 |
| Hong, SJ; Wang, HZ; Wu, KY | 1 |
| Lucente, G; Mollica, A; Paradisi, MP; Spisani, S; Varani, K | 1 |
| Che, Y; Marshall, GR | 1 |
| Jimenez Del Rio, M; Velez-Pardo, C | 1 |
| Anglister, J; Dumy, P; Garcia, J; Rosen, O | 1 |
| Albericio, F; Côté, S; García-Martín, F; Steinauer, R; Tulla-Puche, J; White, P | 1 |
| Dalton, JT; Donkor, IO; Guan, N; Korukonda, R; Liu, J | 1 |
| Baud, S; Keeley, FW; Miao, M; Pomès, R; Rauscher, S | 1 |
| Bérard, J; Camus, MS; Chandravarkar, A; Lashuel, HA; Mimna, R; Murat, K; Mutter, M; Schmid, A; Tuchscherer, G | 1 |
| Abdelly, C; Bordenave, M; Ghars, MA; Lefebvre, D; Leprince, AS; Mazars, C; Parre, E; Richard, L; Savouré, A; Thiery, L | 1 |
| Han, X; Wang, DX | 1 |
| Chang, IS; Choi, GH; Hwang, JS; Kim, H; Lee, B; Son, ED | 1 |
| Fuentes, G; Hood, CA; Menakuru, M; Page, K; Park, JH; Patel, H | 2 |
| Bes, M; Cubero, M; Esteban, JI; Esteban, R; Guardia, J; Otero, T; Quer, J; Sauleda, S | 1 |
| Gonzàlez-Candelas, F; López-Labrador, FX; Moya, A | 1 |
| Del Valle, JR; Liyanage, W; Strong, RK; Weerasinghe, L | 1 |
| Chang, HY; King, CY; Lee, HC; Lin, JY; Wang, HL | 1 |
| Allen, TM; Berical, A; Berlin, AM; Bihl, F; Birch, C; Birren, BW; Carlson, J; Cerny, A; Chung, RT; Daar, ES; Donfield, SM; Edlin, BR; Fleckenstein, JF; Galagan, JE; Gomperts, ED; Heckerman, D; Henn, MR; Jacobson, IM; Kim, AY; Kleyman, M; Kodira, C; Koehrsen, M; Kuntzen, T; Lake-Bakaar, GV; Lauer, GM; Ledlie, T; Lee, B; Lennon, N; Liu, Z; Madey, MA; Marion, T; McMahon, CM; Nusbaum, C; Park, VM; Reyor, LL; Roberts, AD; Rosen, HR; Schneidewind, A; Schulze Zur Wiesch, J; Spengler, U; Talal, AH; Timm, J; Walker, BD; Xing, Y; Young, SK | 1 |
| Chang, ES; Chen, RP; Fann, W; Liao, TY; Lim, TS | 1 |
| Byun, BJ; Kang, YK; Park, HS | 1 |
| Dixon, JE; Lee, SW; Limm, JD; Markley, AL; Mitchell, DA; Nizet, V; Pence, MA | 1 |
| Aravinda, S; Balaram, P; Raghavender, US; Raghothama, S; Shamala, N | 1 |
| Garbay, C; Gautier, B; Goncalves, V; Huguenot, F; Inguimbert, N; Leproux, P; Vidal, M | 1 |
| Ciaramella, G; Corbau, R; Flores, MV; Strawbridge, J | 1 |
| Baleux, F; Coïc, YM; Jamin, N; Lan, CL; Neumann, JM | 1 |
| Sacan, O; Yanardag, R | 1 |
| Deshpande, M; Huang, M; Miller, MD; Mo, H; Murray, B; Qi, X; Rhodes, G; Sun, SC; Wang, K; Wang, Y; Yang, C | 1 |
| Barbeau, O; Brigaud, T; Chaume, G; Lesot, P | 1 |
| Clegg, JK; Fairweather, KA; Jolliffe, KA; Luck, IJ; Sayyadi, N | 1 |
| Bailey, MD; Bhardwaj, PK; Bordeleau, J; Bös, M; Bousquet, Y; Cordingley, MG; Duan, J; Forgione, P; Garneau, M; Ghiro, E; Gorys, V; Goudreau, N; Goulet, S; Halmos, T; Kawai, SH; Llinàs-Brunet, M; Naud, J; Poupart, MA; White, PW | 1 |
| Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Kukolj, G; Lagacé, L; Llinàs-Brunet, M; Thibeault, D; White, PW | 1 |
| Keeley, FW; Muiznieks, LD | 1 |
| Benhamou, Y; Berg, T; Boecher, WO; Bonacini, M; Bourlière, M; Calleja, JL; Kukolj, G; Manns, MP; Pol, S; Scherer, J; Steinmann, G; Stern, JO; Trepo, C; White, PW; Wright, D; Yong, CL | 1 |
| Chen, XY; Fan, SH; Kong, QY; Li, H; Liu, J; Shu, XH; Wang, Q; Wen, S; Wu, ML | 1 |
| Goudreau, N; Hucke, O; Lemke, CT; Llinàs-Brunet, M; Thibeault, D; White, PW; Zhao, S | 1 |
| Gross, A; Heinlein, C; Schmidt, J; Tröster, A; Unverzagt, C; Varón Silva, D | 1 |
| Khungar, V; Poordad, F | 1 |
| Dong, S; Gong, J; Yang, Y; Zhang, B | 1 |
| Ciesek, S; Manns, MP; von Hahn, T | 1 |
| Angus, P; Arasteh, K; Asselah, T; Boecher, WO; Bronowicki, JP; Gane, E; Haefner, C; Heim, M; Kukolj, G; Larrey, D; Lohse, A; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F | 1 |
| Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; De Marte, J; Duan, J; Garneau, M; Jutras, M; Llinàs-Brunet, M; Montpetit, H; Otis, F; Rhéaume, M; White, PW; Yong, CL | 1 |
| Bousquet, C; Dansereau, N; Dô, F; Kukolj, G; Lagacé, L; Llinas-Brunet, M; Marquis, M; Massariol, MJ; Maurice, R; Spickler, C; Thibeault, D; Triki, I; White, PW; Zhao, S | 1 |
| Lok, AS; Sharma, P | 1 |
| Malcolmson, SJ; Walsh, CT; Young, TS | 1 |
| El Kassas, M; El Raziky, M; Esmat, G; Gamil, ME; Hassany, M | 1 |
| Hussar, DA | 1 |
| Brigaud, T; Byun, BJ; Chassaing, G; Chaume, G; Feytens, D; Kang, YK; Lavielle, S; Miclet, E | 1 |
| Amran, SI; Jennings, IG; Kinzler, KW; Schmidt-Kittler, O; Shepherd, PR; Thompson, PE; Vogelstein, B; Zheng, Z; Zhu, J | 1 |
| Asselah, T; Bessone, F; Böcher, WO; Datsenko, Y; Fainboim, H; Ferenci, P; Heo, J; Kukolj, G; Lalezari, J; Leggett, B; Mauss, S; Nehmiz, G; Scherer, J; Steinmann, GG; Stern, JO; Sulkowski, MS | 1 |
| Angus, P; Arasteh, K; Asselah, T; Böcher, WO; Bronowicki, JP; Gane, E; Heim, M; Kukolj, G; Larrey, D; Lohse, AW; Mensa, FJ; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F | 1 |
| Berger, KL; Bethell, R; Cartier, M; Kukolj, G; Lagacé, L; Lawetz, C; Marquis, M; Scherer, J; Triki, I | 1 |
| Asselah, T; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Kukolj, G; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Vinisko, R; Zeuzem, S | 1 |
| Kuboki, M; Nishiguchi, S; Omata, M; Sakai, Y; Sakamoto, W; Steinmann, G; Tsuda, Y; Tsunematsu, S; Urano, Y | 1 |
| Ansari, S; Chee, WW; Moshaverinia, A; Moshaverinia, M; Roohpour, N; Schricker, SR | 1 |
| Brigaud, T; Caupène, C; Chaume, G; Lensen, N; Miclet, E; Simon, J | 1 |
| Bichoupan, K; Dieterich, DT; Martel-Laferrière, V | 1 |
| Berger, KL; Böcher, WO; Cartier, M; Datsenko, Y; Kukolj, G; Marquis, M; Massariol, MJ; Scherer, J; Steinmann, G; Stern, JO; Triki, I | 1 |
| Busacca, CA; Gonnella, N; Li, Y; O'Brien, D; Ramsden, D; Taub, ME; Tweedie, DJ; Xu, J; Zhou, J | 1 |
| Laufer, NL; Rockstroh, JK | 1 |
| Chan, TS; Li, Y; Ramsden, D; Taub, ME; Tweedie, DJ | 1 |
| Chen, LZ; Li, Y; Ramsden, D; St George, R; Tweedie, DJ | 1 |
| Boccaccio, V; Bruno, S | 1 |
| Dieterich, DT; Martel-Laferrière, V | 1 |
| Asselah, T; Marcellin, P | 1 |
| Asselah, T; Halfon, P; Marcellin, P; Schinazi, R | 1 |
| Benhamou, Y; Shiffman, ML | 1 |
| Ford, N; Fortunak, J; Hill, A; Khoo, S; Simmons, B | 1 |
| Chen, LZ; Huang, F; Latli, B; Li, Y; Mandarino, D; Mao, Y; Rose, P; St George, R; Yong, CL | 1 |
| Anwar, MI; Danielson, UH; Ehrenberg, AE; Gustafsson, SS; Schmuck, B; Stenberg, G | 1 |
| Haeggström, JZ; Kleinschmidt, T; Olsson, U; Rinaldo-Matthis, A; Rutishauser, D; Samuelsson, B; Stsiapanava, A; Wan, M; Zubarev, RA | 1 |
| Albericio, F; Postma, TM | 1 |
| Shiffman, ML | 1 |
| Bian, X; Dong, W; Kong, W; Li, Y; Sun, R; Zhao, Y | 1 |
| Akberdin, IR; Clausznitzer, D; Demenkov, PS; Gursky, VV; Ivanisenko, NV; Ivanisenko, VA; Kaderali, L; Kolchanov, NA; Kozlov, KN; Likhoshvai, VA; Mishchenko, EL; Samsonov, AM; Samsonova, MG; Todorov, DI | 1 |
| Asselah, T; Berg, T; Böcher, WO; Datsenko, Y; Dieterich, D; Ferenci, P; Guyader, D; Larrey, D; Maieron, A; Mauss, S; Ozan, M; Ratziu, V; Schuchmann, M; Steinmann, G; Stern, JO | 1 |
| Agarwal, K; Austin, A; Barclay, ST; Brown, A; Dillon, JF; Dundas, P; Dusheiko, GM; Foster, GR; Fox, R; Hayes, PC; Leen, C; Miller, MH; Millson, C; Ryder, SD; Tait, J; Ustianowski, A | 1 |
| Chen, L; George, RS; Mao, Y; Norris, SH; Philip, E; Potchoiba, MJ; Wang, LQ; Wu, D | 1 |
| Böcher, WO; Hennecke, N; Kayser, A; Kukolj, G; Lohmann, V; Martin, B; Neumann-Haefelin, C; Thimme, R | 1 |
| Chen, BP; Chen, W; Chern, Y; He, RY; Huang, JJ; Liu, GC; Sun, CS; Wang, CH; Wang, CY | 1 |
| Ballow, C; Battegay, M; Elgadi, M; Feifel, U; Fuhr, R; Girlich, B; Haschke, M; Kort, J; Lang, B; Li, Y; Sabo, JP; Schobelock, M | 1 |
| Asselah, T; Böcher, WO; Huang, Q; Li, Y; Mease, K; Nehmiz, G; Olson, S; Podila, L; Sane, RS; Steinmann, GG; Stern, JO; Taub, ME; Tweedie, D | 1 |
| Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Gallivan, JP; Mantry, P; Mensa, FJ; Soriano, V; Stern, JO; Taunk, J; Vinisko, R; Zeuzem, S | 1 |
| Elgadi, M; Halabi, A; Huang, F; Lang, B; Moschetti, V; Petersen-Sylla, M; Yong, CL | 1 |
| Elgadi, M; Garcia, J; Huang, F; Joseph, D; Rose, P; Schultz, A; Strelkowa, N | 1 |
| Adeniji, A; Elgadi, M; Huang, F; Joseph, D; Riesenberg, RR; Schobelock, MJ; Vince, BD; Webster, LR | 1 |
| Elgadi, M; Huang, F; Lang, B; Sabo, JP | 1 |
| Ballow, C; Battegay, M; Chan, TS; Cooper, C; Girlich, B; Haschke, M; Kashuba, AD; Kort, J; Lang, B; Li, Y; O'Brien, D; Sabo, JP; Seibert, E; Ting, N; Tweedie, D; Zhang, W | 1 |
| Angus, P; Asselah, T; Böcher, W; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Manns, M; Mensa, FJ; Müllhaupt, B; Roberts, S; Sabo, JP; Schuchmann, M; Soriano, V; Stern, JO; Stickel, F; Voss, F; Zeuzem, S | 1 |
| Agarwal, K; Asselah, T; Bourlière, M; Calinas, F; Crespo, J; Datsenko, Y; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; Garcia, M; Kukolj, G; Maevskaya, M; Morano, LE; Moreno, C; Nishiguchi, S; Omata, M; Ouzan, D; Quinson, AM; Sarrazin, C; Scherer, J; Schuchmann, M; Stern, JO; Zehnter, E; Zeuzem, S | 1 |
| Agarwal, K; Barnabas, A | 1 |
| Brimble, MA; Harris, PW | 1 |
| Arastéh, K; Bhagani, S; Dieterich, D; Guardiola, JM; Ingiliz, P; Jain, MK; Kort, J; Laguno, M; Manero, M; Nelson, M; Rockstroh, JK; Soriano, V; Stern, JO; Tural, C; Vinisko, R | 1 |
| Kanda, T; Omata, M; Yokosuka, O | 1 |
| Campagna, D; Demma, S | 1 |
| Ambrosioni, J; Aouri, M; Böni, J; Cavassini, M; Decosterd, L; Fehr, J; Furrer, H; Günthard, HF; Haubitz, S; Kovari, H; Ledergerber, B; Metzner, KJ; Rauch, A; Schaerer, V; Schmid, P; Stoeckle, M | 1 |
| Berger, KL; Kukolj, G; Quinson, AM; Ranga, M; Scherer, J; Sha, N; Stern, JO | 1 |
| Asselah, T; Bourlière, M; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; García-Samaniego, J; Maevskaya, M; Mantry, P; Oliveira, C; Quinson, AM; Sha, N; Stern, JO; Warner, N; Wright, D; Wright, M; Yoshida, EM | 1 |
| Asselah, T; Baum, P; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Voss, F; Zeuzem, S | 1 |
| Elgadi, M; Gießmann, T; Huang, F; Lang, B; Wu, J | 1 |
| Angus, P; Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Kadus, W; Mantry, P; Mensa, FJ; Pockros, PJ; Soriano, V; Stern, JO; Vinisko, R; Wright, D; Zeuzem, S | 1 |
| Busacca, CA; Davis, M; Ding, A; Gonnella, NC; Grupe, J; Herfurth, L; Jones, PJ; Li, G; Niemann, M; Offerdahl, T; Reckzügel, G; Reddig, T; Roos, H; Saha, A; Wagner, K; Werthmann, U; Wu, JP; Zhang, L | 1 |
| Bao, RF; Cao, Y; Chen, L; Hu, YP; Jiang, L; Li, HF; Liang, HB; Liu, SB; Liu, YB; Ma, Q; Shu, YJ; Wang, XA; Wang, Z; Xu, Y; Zhang, F; Zhang, YC; Zhang, YJ; Zhao, S; Zhou, J | 1 |
| Berger, KL; Côté-Martin, A; Kukolj, G; Marquis, M; Mensa, FJ; Nelson, DR; Sarrazin, C; Scherer, J; Sha, N; Stern, JO; Vinisko, R | 1 |
| Aichholz, R; Blanz, J; Blasco, F; Caravatti, G; Fairhurst, RA; Fritsch, C; Guagnano, V; Maira, SM; Schnell, C; Seiler, FH; Wipfli, P | 1 |
| Hannongbua, S; Kungwan, N; Meeprasert, A; Rungrotmongkol, T | 1 |
| Connelly, KA; Gilbert, RE; Kapus, A; Kepecs, D; Thai, K; Wu, X; Zhang, Y | 1 |
| Bai, X; Calleja, JL; Forns, X; Garcia-Samaniego, J; Kaste, R; Manns, M; Sarrazin, C; Stern, JO; Wu, J | 1 |
| Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Quinson, AM; Strelkowa, N | 1 |
| Du, W; Gou, X; Hu, J; Liang, L; Liu, W; Zuo, K | 1 |
| Jaspars, M; Naismith, JH; Oueis, E; Stevenson, H; Westwood, NJ | 1 |
| Brigaud, T; Chaume, G; Lensen, N; Miclet, E; Pytkowicz, J; Simon, J | 1 |
| Huang, F; Rowland, L; Sabo, JP; Schultz, A; Trampisch, M; Voelk, C | 1 |
| Brigaud, T; Chaume, G; Lensen, N; Malquin, N; Miclet, E; Rahgoshay, K | 1 |
| Burkart, MD; Corpuz, JC; Davis, TD; Jaremko, MJ | 1 |
| Keiper, O; Schöwe, MJ; Unverzagt, C; Wittmann, V | 1 |
| Artym, J; Jankowski, S; Jędrzejczak, K; Katarzyńska, J; Kochanowska, I; Lisowski, M; Marcinek, A; Piotrowski, Ł; Wieczorek, R; Zabrocki, J; Zimecki, M | 1 |
| Ivanov, IA; Kasheverov, IE; Senko, DA; Timofeev, ND | 1 |
| Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Strelkowa, N | 1 |
| Hager, HH; Kashif Khan, R; Meanwell, NA | 1 |
17 review(s) available for proline and thiazoles
| Article | Year |
|---|---|
Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis.
Topics: Acylation; Amino Acid Sequence; Molecular Structure; Organophosphorus Compounds; Peptide Fragments; Peptides; Proline; Resins, Synthetic; Temperature; Thiazoles; Thiocyanates; Triazoles | 2007 |
Emerging therapeutic options in hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication | 2011 |
Second-wave protease inhibitors: choosing an heir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2011 |
The future for the treatment of genotype 4 chronic hepatitis C.
Topics: Albumins; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Nitro Compounds; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Thiazoles; Time Factors; Viral Load; Vitamin D | 2012 |
Hepatitis C direct-acting antiviral agents: changing the paradigm of hepatitis C treatment in HIV-infected patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Coinfection; Hepatitis C; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferons; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2014 |
Faldaprevir (BI 201335) for the treatment of hepatitis C in patients co-infected with HIV.
Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Availability; Clinical Trials as Topic; Coinfection; Drug Administration Schedule; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Virus Replication | 2014 |
Management of HCV patients with cirrhosis with direct acting antivirals.
Topics: Algorithms; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Liver Cirrhosis; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
Treating HCV in HIV 2013: on the cusp of change.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine | 2014 |
Second-wave IFN-based triple therapy for HCV genotype 1 infection: simeprevir, faldaprevir and sofosbuvir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
HCV direct-acting antiviral agents: the best interferon-free combinations.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials as Topic; Disease Eradication; Drug Discovery; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon-alpha; Isoquinolines; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pyrrolidines; Quinolines; Recombinant Proteins; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine; Viral Nonstructural Proteins; Virus Replication | 2014 |
HCV F1/F2 patients: treat now or continue to wait.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Treatment Outcome; Uridine Monophosphate | 2014 |
Hepatitis C virus therapy in the direct acting antiviral era.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Sofosbuvir; Thiazoles; Uridine Monophosphate | 2014 |
Faldaprevir for the treatment of genotype-1 hepatitis C virus.
Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Ribavirin; Thiazoles | 2015 |
Faldaprevir for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2015 |
Faldaprevir for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Discovery; Drug Interactions; Hepatitis C; Humans; Leucine; Molecular Structure; Oligopeptides; Proline; Quinolines; Thiazoles; Tissue Distribution; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.
Topics: Amino Acids; Benzoic Acid; Cyclopropanes; Hydroxylation; Lactams; Macrolides; Netropsin; Peptide Synthases; Proline; Protein Interaction Maps; Pyrroles; Thiazoles; Thiones | 2020 |
Pseudoprolines as stereoelectronically tunable proline isosteres.
Topics: Amides; Carbon; Dipeptides; Oligopeptides; Oxygen; Peptides; Proline; Pyrrolidines; Selenium; Silicon; Sulfur; Thiazoles | 2022 |
30 trial(s) available for proline and thiazoles
| Article | Year |
|---|---|
Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes.
Topics: Aged; Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Female; Genotype; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Proline; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Treatment Outcome | 2003 |
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Load; Viral Nonstructural Proteins | 2011 |
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Thiazoles; Treatment Outcome; Viral Load; Viral Nonstructural Proteins | 2011 |
Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Nonstructural Proteins | 2013 |
Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load | 2013 |
Viral resistance in hepatitis C virus genotype 1-infected patients receiving the NS3 protease inhibitor Faldaprevir (BI 201335) in a phase 1b multiple-rising-dose study.
Topics: Aminoisobutyric Acids; Antiviral Agents; Cell Line; Genotype; Genotyping Techniques; Hepacivirus; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2013 |
Faldaprevir and deleobuvir for HCV genotype 1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; DNA-Directed RNA Polymerases; Enzyme Inhibitors; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load | 2013 |
Safety and efficacy of faldaprevir with pegylated interferon alfa-2a and ribavirin in Japanese patients with chronic genotype-1 hepatitis C infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Asian People; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Time Factors; Treatment Outcome | 2014 |
Mass balance and metabolite profiling of steady-state faldaprevir, a hepatitis C virus NS3/4 protease inhibitor, in healthy male subjects.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Hepacivirus; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Young Adult | 2014 |
SILEN-C3, a phase 2 randomized trial with faldaprevir plus pegylated interferon α-2a and ribavirin in treatment-naive hepatitis C virus genotype 1-infected patients.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2014 |
Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.
Topics: Acrylates; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Contraindications; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Virus Replication | 2014 |
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir.
Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult | 2014 |
Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.
Topics: Aminoisobutyric Acids; Animals; Bilirubin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Hyperbilirubinemia; Leucine; Liver; Macaca mulatta; Multicenter Studies as Topic; Multidrug Resistance-Associated Protein 2; Oligopeptides; Proline; Quinolines; Randomized Controlled Trials as Topic; Rats; Thiazoles | 2014 |
Interferon-free treatment of chronic hepatitis C with faldaprevir, deleobuvir and ribavirin: SOUND-C3, a Phase 2b study.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Treatment Outcome | 2015 |
Pharmacokinetics, safety, and tolerability of faldaprevir in patients with renal impairment.
Topics: Adult; Aged; Aminoisobutyric Acids; Biological Availability; Female; Half-Life; Hepatitis C; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Renal Insufficiency; Thiazoles | 2015 |
Effect of faldaprevir on raltegravir pharmacokinetics in healthy volunteers.
Topics: Adult; Aminoisobutyric Acids; Drug Administration Schedule; Drug Interactions; Female; Genotype; Glucuronosyltransferase; Healthy Volunteers; HIV Integrase Inhibitors; Humans; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Raltegravir Potassium; Thiazoles; Young Adult | 2015 |
Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Interactions; Female; Humans; Leucine; Male; Methadone; Middle Aged; Oligopeptides; Proline; Quinolines; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles; Young Adult | 2015 |
Effect of the hepatitis C virus protease inhibitor faldaprevir on the pharmacokinetics of an oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aminoisobutyric Acids; Area Under Curve; Bilirubin; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Leucine; Levonorgestrel; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2015 |
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Hepatitis C; Humans; In Vitro Techniques; Isoenzymes; Leucine; Male; Microsomes, Liver; Midazolam; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Warfarin; Young Adult | 2015 |
Efficacy and safety of faldaprevir, deleobuvir, and ribavirin in treatment-naive patients with chronic hepatitis C virus infection and advanced liver fibrosis or cirrhosis.
Topics: Acrylates; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Female; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Ribavirin; Thiazoles; Young Adult | 2015 |
STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles | 2015 |
Faldaprevir and pegylated interferon α-2a/ribavirin in individuals co-infected with hepatitis C virus genotype-1 and HIV.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Leucine; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load; Viremia; Young Adult | 2015 |
Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
Open-label study of faldaprevir plus peginterferon and ribavirin in hepatitis C virus genotype 1-infected patients who failed placebo plus peginterferon and ribavirin.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Placebos; Proline; Quinolines; Ribavirin; Salvage Therapy; Thiazoles; Treatment Outcome | 2016 |
ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.
Topics: Acrylates; Aminoisobutyric Acids; Anemia; Antiviral Agents; Benzimidazoles; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Male; Middle Aged; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Pyrophosphatases; Quinolines; Real-Time Polymerase Chain Reaction; Ribavirin; Thiazoles | 2015 |
Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Food-Drug Interactions; Healthy Volunteers; Hepacivirus; Humans; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Oligopeptides; Omeprazole; Proline; Protease Inhibitors; Proton Pump Inhibitors; Quinolines; Risk Factors; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2016 |
Short article: Faldaprevir, deleobuvir and ribavirin in IL28B non-CC patients with HCV genotype-1a infection included in the SOUND-C3 phase 2b study.
Topics: Acrylates; Adult; Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Leucine; Male; Middle Aged; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA, Viral; Sustained Virologic Response; Thiazoles; Time Factors; Treatment Outcome; United States | 2016 |
HCVerso3: An Open-Label, Phase IIb Study of Faldaprevir and Deleobuvir with Ribavirin in Hepatitis C Virus Genotype-1b-Infected Patients with Cirrhosis and Moderate Hepatic Impairment.
Topics: Acrylates; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Prognosis; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Viral Load; Young Adult | 2016 |
Effect of Steady-State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open-Label, Fixed-Sequence Crossover Study.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Atorvastatin; Cross-Over Studies; Drug Interactions; Female; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Male; Middle Aged; Oligopeptides; Proline; Pyrimidines; Quinolines; Rosuvastatin Calcium; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles | 2017 |
Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Graft Rejection; Healthy Volunteers; Hepatitis C; Humans; Immunosuppressive Agents; Leucine; Liver Transplantation; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Quinolines; Secondary Prevention; Tacrolimus; Thiazoles; Young Adult | 2018 |
125 other study(ies) available for proline and thiazoles
| Article | Year |
|---|---|
Metal-ion interaction with penicillins: kinetics of complexation of nickel(II).
Topics: Ampicillin; Carboxylic Acids; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Kinetics; Lactams; Ligands; Nickel; Penicillin G; Penicillins; Proline; Thiazoles | 1977 |
The variability of human lambda-chain constant regions and some relationships to V-regions sequences.
Topics: Alanine; Amino Acid Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cystine; Electrophoresis, Paper; Glutamates; Glycine; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Isoleucine; Leucine; Peptides; Proline; Serine; Thiazoles; Threonine; Valine | 1976 |
Conformational studies of peptides. The crystal structures of N-acetyl-L-prolinamide and N-acetyl-(S)-thiazolidine-4-carboxamide.
Topics: Acetylation; Amides; Crystallography; Molecular Conformation; Peptides; Proline; Temperature; Thiazoles; X-Ray Diffraction | 1976 |
Studies on endogenous formation of N-nitroso compounds in the guinea pig supplemented with proline or thioproline and sodium nitrate.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Gastric Acidity Determination; Guinea Pigs; Hydrogen-Ion Concentration; Male; Nitrates; Nitrosamines; Nitrosation; Nitroso Compounds; Proline; Thiazoles; Thiazolidines | 1992 |
Synthesis and secretion of gastric sulfomucin in the presence of ebrotidine, a new antiulcer agent.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Dose-Response Relationship, Drug; Gastric Mucosa; Glucosamine; Glycosylation; Kinetics; Mucins; Proline; Rats; Sulfates; Thiazoles | 1992 |
Oxidation of L-thiazolidine-4-carboxylate by L-proline dehydrogenase in Escherichia coli.
Topics: Antioxidants; Cell Membrane; Escherichia coli; Kinetics; Oxidation-Reduction; Oxygen; Proline; Proline Oxidase; Spectrum Analysis; Thiazoles; Thiazolidines | 1992 |
5,5-Dimethylthiazolidine-4-carboxylic acid (DTC) as a proline analog with restricted conformation.
Topics: Amino Acid Sequence; Hydrogen Bonding; Peptides; Proline; Protein Conformation; Spectrophotometry, Infrared; Thiazoles; X-Ray Diffraction | 1990 |
Electrochemistry of cyclic alpha-imino carboxylates and their metal complexes: correlation with physiological activity.
Topics: Copper; Electrochemistry; Iron; Ligands; Oxidation-Reduction; Proline; Structure-Activity Relationship; Thiazoles | 1989 |
Macrophage-mediated N-nitrosation of thioproline and proline.
Topics: Animals; Cell Line, Transformed; Macrophage Activation; Macrophages; Mice; Morpholines; Nitrosamines; Proline; Thiazoles; Thiazolidines | 1989 |
[Effects of thiazolidine-4-carboxylic acid on germ tube formation and L-[14C(U)] proline uptake in Candida albicans].
Topics: Antineoplastic Agents; Candida albicans; Culture Media; Dose-Response Relationship, Drug; Proline; Thiazoles; Thiazolidines | 1985 |
Specificity of feeding chemoreceptors in Palythoa psammophilia (Zoanthidea, Coelenterata).
Topics: Animals; Chemoreceptor Cells; Cnidaria; Crustacea; Drug Interactions; Feeding Behavior; Glutathione; Hydrogen-Ion Concentration; Hydroxyproline; Mouth; Peptides; Pipecolic Acids; Proline; Thiazoles; Time Factors | 1971 |
Some properties of proline-sRNA synthetase from rat liver.
Topics: Amino Acids; Animals; Calcium; Carbon Isotopes; Enzymes; Hydroxamic Acids; In Vitro Techniques; Lipotropic Agents; Liver; Magnesium; Manganese; Mercaptoethanol; Mercaptoethylamines; Proline; Rats; Ribonucleases; Sucrose; Thiazoles | 1966 |
Sequential polypeptides. VI. The synthesis of some sequential polypeptide collagen models containing proline analogues.
Topics: Amino Acid Sequence; Amino Acids; Collagen; Models, Chemical; Molecular Weight; Peptides; Pipecolic Acids; Proline; Thiazoles | 1972 |
Imino acid transport in yeast: the uptake of sarcosine.
Topics: Amino Acids; Azetines; Azides; Biological Transport, Active; Carbon Isotopes; Carbon Radioisotopes; Chromatography, Paper; Dinitrophenols; Kinetics; Proline; Saccharomyces; Sarcosine; Structure-Activity Relationship; Temperature; Thiazoles; Time Factors | 1973 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
Inhibition of radiosulfate uptake in rat costal cartilage by lipophilic heterocyclic molecules.
Topics: Alcohols; Animals; Benzene Derivatives; Benzoxazoles; Carbon Isotopes; Cartilage; Chemical Phenomena; Chemistry; Chondroitin; In Vitro Techniques; Indoles; Male; Metabolism; Proline; Protein Biosynthesis; Quinolines; Rats; Skatole; Sulfates; Sulfur Isotopes; Sulfuric Acids; Surface Properties; Thiazoles | 1970 |
Optical resolution of D,L amino acids by gas chromatography and mass spectrometry.
Topics: Alanine; Amino Acids; Aminobutyrates; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; Glycine; Leucine; Proline; Spectrum Analysis; Thiazoles | 1965 |
Effect of H2 blockers on intragastric nitrosation as measured by 24-hour urinary secretion of N-nitrosoproline.
Topics: Adult; Duodenal Ulcer; Histamine H2 Antagonists; Humans; Male; Middle Aged; Nitrosamines; Nitroso Compounds; Proline; Ranitidine; Thiazoles; Thiazolidines | 1984 |
Effect of captopril on intrarenal blood flow.
Topics: Animals; Captopril; Diuresis; Diuretics; Dogs; Furosemide; Glomerular Filtration Rate; Humans; Hypertension; Kidney Concentrating Ability; Kidney Glomerulus; Male; Osmolar Concentration; Proline; Propranolol; Rats; Renal Circulation; Renin; Renin-Angiotensin System; Stereoisomerism; Thiazoles; Vasoconstriction | 1984 |
Assessment of endogenous nitrosation in humans in relation to the risk of cancer of the digestive tract.
Topics: Ascorbic Acid; Dose-Response Relationship, Drug; Esophageal Neoplasms; Gastrointestinal Neoplasms; Humans; Kinetics; Nitrosamines; Nitroso Compounds; Precancerous Conditions; Proline; Risk; Thiazoles; Thiazolidines | 1983 |
[Diminution of the rate of growth of HeLa cells caused by thioproline (Tp) and 2-aminothiazoline HCl (2-AT). Effect of L-proline].
Topics: Growth Inhibitors; HeLa Cells; Humans; Proline; Thiazoles; Thiazolidines | 1982 |
Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors.
Topics: Animals; Azetidinecarboxylic Acid; Fasciola; Fascioliasis; Female; Hydroxylamine; Hydroxylamines; Proline; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1982 |
Ac-[3- and 4-alkylthioproline31]-CCK4 analogs: synthesis and implications for the CCK-B receptor-bound conformation.
Topics: Amino Acid Sequence; Animals; Cholecystokinin; Humans; Male; Models, Molecular; Molecular Sequence Data; Proline; Protein Conformation; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1995 |
Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Macrocyclic Compounds; Magnetic Resonance Spectroscopy; Molecular Structure; Proline; Serine; Thiazoles | 1994 |
The effect of 2-substituted thiazolidine-4(R)-carboxylic acids on non-protein sulphydryl levels and sulphurtransferase activities in mouse liver and brain.
Topics: Animals; Brain; Female; Liver; Mice; Proline; Sulfhydryl Compounds; Sulfurtransferases; Thiazoles; Thiazolidines; Thiosulfate Sulfurtransferase | 1993 |
Effect of ebrotidine on the synthesis and secretion of gastric sulfomucin.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Gastric Mucosa; Glucosamine; Glycoproteins; In Vitro Techniques; Mucins; Proline; Rats; Sulfates; Sulfur Radioisotopes; Thiazoles | 1993 |
Sensitivity of Escherichia coli to proline analogues during osmotic stress and anaerobiosis.
Topics: Anaerobiosis; Azetidinecarboxylic Acid; Betaine; Drug Resistance, Microbial; Drug Stability; Escherichia coli; Escherichia coli Infections; Humans; Microbial Sensitivity Tests; Osmotic Pressure; Proline; Thiazoles; Thiazolidines; Urinary Tract Infections | 1996 |
2,4 Dinitrophenol-uncoupling effect on delta psi in living hepatocytes depends on reducing-equivalent supply.
Topics: 2,4-Dinitrophenol; Animals; Caprylates; Cells, Cultured; Flow Cytometry; Fluorescent Dyes; Intracellular Membranes; Kinetics; Liver; Male; Membrane Potentials; Methacrylates; Mitochondria, Liver; Proline; Rats; Rats, Wistar; Rhodamine 123; Rhodamines; Thiazoles; Uncoupling Agents | 1998 |
Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts.
Topics: Areca; Cell Adhesion; Cell Division; Cells, Cultured; Collagen; Coloring Agents; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Gingiva; Humans; Periodontal Diseases; Plant Extracts; Plants, Medicinal; Prevalence; Proline; Radiopharmaceuticals; Tetrazolium Salts; Thiazoles; Time Factors; Tritium; Vacuoles | 1998 |
The effects of extracellular citric acid acidosis on the viability, cellular adhesion capacity and protein synthesis of cultured human gingival fibroblasts.
Topics: Acidosis; Cell Adhesion; Cell Death; Cell Movement; Cell Survival; Cells, Cultured; Chelating Agents; Chemical Precipitation; Citrates; Citric Acid; Collagen; Coloring Agents; Culture Media; Fibroblasts; Gingiva; Humans; Hydrogen-Ion Concentration; Proline; Protein Biosynthesis; Proteins; Radiopharmaceuticals; Sodium Citrate; Tetrazolium Salts; Thiazoles; Trichloroacetic Acid; Tritium; Wound Healing | 1999 |
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine | 2000 |
The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation.
Topics: Amino Acid Substitution; Amyloidosis; Benzothiazoles; Crystallization; Doxorubicin; Humans; Iodine; Leucine; Models, Molecular; Prealbumin; Proline; Protein Binding; Protein Structure, Secondary; Thiazoles; X-Ray Diffraction | 2000 |
Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases.
Topics: Amino Acids; Animals; Dipeptidyl Peptidase 4; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Proline; Protease Inhibitors; Pyrroles; Substrate Specificity; Swine; Thiazoles | 2000 |
Dysideaprolines A-F and barbaleucamides A-B, novel polychlorinated compounds from a Dysidea species.
Topics: Animals; Chromatography, High Pressure Liquid; Cyanobacteria; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Molecular Structure; Philippines; Porifera; Proline; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2001 |
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Topics: Animals; Brain; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Oxazoles; Proline; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiazoles; Vas Deferens | 2001 |
A protein sequence that can encode native structure by disfavoring alternate conformations.
Topics: Amino Acid Sequence; Benzothiazoles; Cell Line; Cell Membrane; Circular Dichroism; Computational Biology; Cystic Fibrosis Transmembrane Conductance Regulator; Genome; Humans; Liposomes; Micelles; Molecular Sequence Data; Mutation; Proline; Protein Folding; Protein Structure, Secondary; Recombinant Fusion Proteins; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Thermodynamics; Thiazoles | 2002 |
Novel dipeptide macrocycles from 4-oxo, -thio, and -amino-substituted proline derivatives.
Topics: Cyclization; Dipeptides; Drug Design; Proline; Thiazoles; Thiazolidines | 2002 |
Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Copper; Isoleucine; Microscopy, Electron; Neurons; Oxidative Stress; Peptide Fragments; Proline; Rats; Thiazoles | 2002 |
Rotenone-insensitive NADH dehydrogenase is a potential source of superoxide in procyclic Trypanosoma brucei mitochondria.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Biphenyl Compounds; Fumarates; Malates; Methacrylates; Mitochondria; NAD; NADH Dehydrogenase; Onium Compounds; Polyenes; Proline; Rotenone; Substrate Specificity; Succinic Acid; Superoxides; Thiazoles; Trypanosoma brucei brucei; Ubiquinone; Uncoupling Agents | 2002 |
Synthesis of an oxazoline analogue of apratoxin A.
Topics: Antineoplastic Agents; Cyclization; Cytotoxins; Depsipeptides; Ketones; Lactones; Models, Chemical; Molecular Structure; Oxazoles; Peptides; Peptides, Cyclic; Proline; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2003 |
[EFFECT OF THIAZOLIDINE-4-CARBOXYLIC ACID ON THE DEVELOPMENT OF THE EGG OF THE SEA URCHIN PARACENTROTUS LIVIDUS].
Topics: Animals; Echinodermata; Ovum; Paracentrotus; Pharmacology; Proline; Research; Sea Urchins; Thiazoles; Thiazolidines | 1964 |
INHIBITION OF PROLINE-C14 INCORPORATION INTO RAT LIVER RIBOSOMES BY THIAZOLIDINE-4-CARBOXYLIC ACID IN A CELL-FREE SYSTEM.
Topics: Carbon Isotopes; Cell-Free System; Hydroxyproline; Liver; Metabolism; Proline; Rats; Research; Ribosomes; RNA; Sulfur Isotopes; Thiazoles; Thiazolidines | 1965 |
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
Topics: Animals; Annexin A5; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Body Weight; Camptothecin; Cell Line, Tumor; Cisplatin; Coloring Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Male; Metalloporphyrins; Mice; Mitomycin; Neoplasms; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen; Polyethylene Glycols; Proline; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2004 |
Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dipeptides; Indoles; Kidney; Kidney Cortex; Male; Myocardium; Nitriles; Oligopeptides; Organ Specificity; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Thiazoles; Thiazolidines; Thymosin | 2004 |
Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides.
Topics: Animals; Antifungal Agents; Antimicrobial Cationic Peptides; Aspergillus; Candida albicans; Circular Dichroism; Fusarium; Gene Deletion; Leucine; Magainins; Peptides; Proline; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trichosporon; Xenopus; Xenopus Proteins | 2004 |
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog.
Topics: Conotoxins; Models, Molecular; Molecular Conformation; Peptides; Proline; Stereoisomerism; Thiazoles | 2004 |
Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP, a highly amyloidogenic and aggregation-prone polypeptide.
Topics: Amino Acid Sequence; Amyloid; Dipeptides; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Oxazoles; Proline; Thiazoles | 2005 |
ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Binding Sites; Carrier Proteins; Cell Line; Cell Survival; COS Cells; DNA Damage; DNA, Complementary; Exons; Glutathione Transferase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HeLa Cells; Homeodomain Proteins; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Models, Biological; p21-Activated Kinases; Phosphorylation; Plasmids; Proline; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; RNA-Binding Proteins; src Homology Domains; Tetrazolium Salts; Thiazoles; Transfection; Two-Hybrid System Techniques | 2005 |
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
Topics: Amino Acids; Aminopeptidases; Animals; Binding Sites; Escherichia coli; Kinetics; Leucine; Proline; Protease Inhibitors; Pyrroles; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles | 2005 |
Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Matrix; Fibroblast Growth Factor 2; Formaldehyde; Humans; Immunohistochemistry; In Vitro Techniques; Laminin; Lysine; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Osteosarcoma; Plant Extracts; Platelet-Derived Growth Factor; Proline; Proteoglycans; Tea; Tetrazolium Salts; Thiazoles; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2005 |
Introduction of a cis-prolyl mimic in position 7 of the peptide hormone oxytocin does not result in antagonistic activity.
Topics: Animals; Binding, Competitive; Blood Pressure; CHO Cells; Cricetinae; Cricetulus; Female; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Molecular Mimicry; Oxytocin; Proline; Radioligand Assay; Rats; Receptors, Oxytocin; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Uterine Contraction; Uterus | 2005 |
Effect of latanoprost on cultured porcine corneal stromal cells.
Topics: Animals; Benzalkonium Compounds; Calcium; Cell Movement; Cells, Cultured; Collagen Type I; Corneal Stroma; Fibronectins; Fluorescent Antibody Technique; Immunoblotting; Intracellular Membranes; Latanoprost; Leucine; Proline; Prostaglandins F, Synthetic; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Thymidine; Uridine | 2005 |
Chemotactic peptides: fMLF-OMe analogues incorporating proline-methionine chimeras as N-terminal residue.
Topics: Cytoplasmic Granules; Humans; Magnetic Resonance Spectroscopy; Methionine; Molecular Conformation; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Proline; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2006 |
Impact of cis-proline analogs on peptide conformation.
Topics: Binding Sites; Biopolymers; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Models, Statistical; Models, Theoretical; Molecular Conformation; Nitrogen; Normal Distribution; Peptides; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Temperature; Tetrazoles; Thermodynamics; Thiazoles; Thiazolidines | 2006 |
Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway.
Topics: Adult; Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Chromones; Humans; Hydrogen Peroxide; In Vitro Techniques; Insulin-Like Growth Factor I; Lymphocytes; Male; Mitochondrial Membranes; Morpholines; NF-kappa B; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proline; Thiazoles; Thiocarbamates; Toluene; Tumor Suppressor Protein p53; Up-Regulation | 2006 |
Stabilization of the biologically active conformation of the principal neutralizing determinant of HIV-1(IIIB) containing a cis-proline surrogate: 1H NMR and molecular modeling study.
Topics: Amino Acid Sequence; Enzyme-Linked Immunosorbent Assay; HIV Envelope Protein gp120; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Proline; Protein Conformation; Stereoisomerism; Thiazoles | 2006 |
The synergy of ChemMatrix resin and pseudoproline building blocks renders RANTES, a complex aggregated chemokine.
Topics: Amino Acid Sequence; Chemokine CCL5; Dipeptides; Humans; Molecular Sequence Data; Polystyrenes; Proline; Thiazoles | 2006 |
Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.
Topics: Aldehydes; Calpain; Cathepsin B; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; HeLa Cells; Humans; Molecular Structure; Proline; Pyrrolidinones; Stereoisomerism; Structure-Activity Relationship; Sulfones; Thiazoles; Thiazolidines | 2006 |
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Chickens; Elastin; Entropy; Glycine; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Conformation; Thiazoles; Triticum | 2006 |
Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis.
Topics: Amyloid; Microscopy, Electron; Models, Biological; Models, Molecular; Peptides; Proline; Protein Folding; Protein Precursors; Protein Structure, Secondary; Thiazoles | 2007 |
Calcium signaling via phospholipase C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis.
Topics: Arabidopsis; Boron Compounds; Calcium; Calcium Signaling; Estrenes; Indoles; Inositol 1,4,5-Trisphosphate; Molecular Sequence Data; Osmotic Pressure; Proline; Pyrimidinones; Pyrrolidinones; Seedlings; Sodium Chloride; Thiazoles; Type C Phospholipases; Water | 2007 |
Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice.
Topics: Administration, Topical; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Dipeptidases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Image Processing, Computer-Assisted; Ketoglutaric Acids; Mice; Mice, Hairless; Procollagen; Proline; Skin; Skin Aging; Stimulation, Chemical; Tetrazolium Salts; Thiazoles; Ultraviolet Rays | 2007 |
Fast Fmoc synthesis of hAmylin1-37 with pseudoproline assisted on-resin disulfide formation.
Topics: Amino Acids; Amyloid; Chromatography, High Pressure Liquid; Cyclization; Disulfides; Fluorenes; Fluoroacetates; Humans; Islet Amyloid Polypeptide; Molecular Conformation; Oligopeptides; Proline; Stereoisomerism; Thallium; Thiazoles; Time Factors; Trifluoroacetic Acid | 2007 |
Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient.
Topics: Adult; Amino Acid Sequence; Base Sequence; Carbamates; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Macrocyclic Compounds; Male; Molecular Sequence Data; Oligopeptides; Point Mutation; Proline; Quinolines; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins | 2008 |
Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates.
Topics: Amino Acid Sequence; Antiviral Agents; Carbamates; Carrier Proteins; Drug Resistance, Viral; Global Health; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Microbial Sensitivity Tests; Molecular Sequence Data; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Sequence Alignment; Thiazoles; Viral Nonstructural Proteins; Viral Proteins | 2008 |
Synthesis of carbapyochelins via diastereoselective azidation of 5-(ethoxycarbonyl)methylproline derivatives.
Topics: Azides; Crystallography, X-Ray; Models, Molecular; Molecular Conformation; Phenols; Proline; Stereoisomerism; Thiazoles | 2008 |
Strain-specific sequences required for yeast [PSI+] prion propagation.
Topics: Amino Acid Sequence; Benzothiazoles; Glycine; Peptide Termination Factors; Prions; Proline; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles | 2008 |
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients.
Topics: Antiviral Agents; Carbamates; Cohort Studies; Drug Resistance, Viral; Female; Genetic Testing; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Male; Mutation; Oligopeptides; Phenylthiourea; Phylogeny; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load; Viral Nonstructural Proteins | 2008 |
A new amyloid-like beta-aggregate with amyloid characteristics, except fibril morphology.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Cell Line, Tumor; Congo Red; Mice; Models, Biological; Mutant Proteins; Mutation; Peptides; Proline; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles; Time Factors; Valine | 2009 |
Puckering transitions of pseudoproline residues.
Topics: Models, Molecular; Molecular Structure; Phase Transition; Proline; Thiazoles | 2009 |
Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Mice; Molecular Sequence Data; Oxazoles; Proline; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Streptococcus pyogenes; Streptolysins; Substrate Specificity; Surface Plasmon Resonance; Thiazoles; Virulence | 2009 |
Conformations of heterochiral and homochiral proline-pseudoproline segments in peptides: context dependent cis-trans peptide bond isomerization.
Topics: Hydrogen Bonding; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proline; Protein Structure, Secondary; Stereoisomerism; Thiazoles; X-Ray Diffraction | 2009 |
Total chemical synthesis of the D2 domain of human VEGF receptor 1.
Topics: Humans; Peptides; Proline; Protein Folding; Protein Structure, Tertiary; Thiazoles; Vascular Endothelial Growth Factor Receptor-1 | 2009 |
Fully automated fast Fmoc synthesis and on-resin disulfide bridge formation with pseudoproline dipeptides on the Prelude.
Topics: Automation; Chromatography, High Pressure Liquid; Dipeptides; Disulfides; Fluorenes; Proline; Thiazoles | 2009 |
HCV-NS3 inhibitors: determination of their kinetic parameters and mechanism.
Topics: Amino Acid Substitution; Antiviral Agents; Carbamates; Drug Resistance, Viral; Genotype; Half-Life; Hepacivirus; Humans; Kinetics; Macrocyclic Compounds; Models, Biological; Mutation; Oligopeptides; Proline; Quinolines; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins | 2009 |
Slightly modifying pseudoproline dipeptides incorporation strategy enables solid phase synthesis of a 54 AA fragment of caveolin-1 encompassing the intramembrane domain.
Topics: Amino Acid Sequence; Caveolin 1; Chromatography, High Pressure Liquid; Dipeptides; Magnetic Resonance Spectroscopy; Membrane Proteins; Molecular Sequence Data; Proline; Thiazoles | 2010 |
Antioxidant and antiacetylcholinesterase activities of chard (Beta vulgaris L. var. cicla).
Topics: Anthocyanins; Benzothiazoles; Beta vulgaris; Biphenyl Compounds; Cholinesterase Inhibitors; Free Radical Scavengers; Free Radicals; In Vitro Techniques; Phenols; Picrates; Plant Extracts; Plants, Medicinal; Proline; Sulfonic Acids; Thiazoles | 2010 |
Estimation of inhibitory quotient using a comparative equilibrium dialysis assay for prediction of viral response to hepatitis C virus inhibitors.
Topics: Antiviral Agents; Blood Proteins; Carbamates; Cell Line; Comparative Effectiveness Research; Dialysis; Hepacivirus; Hepatitis C; Humans; Inhibitory Concentration 50; Macrocyclic Compounds; Membranes, Artificial; Oligopeptides; Phenylthiourea; Plasma; Proline; Protease Inhibitors; Protein Binding; Quinolines; RNA, Viral; Thiazoles; Viral Load | 2011 |
Synthesis of 2-trifluoromethyl-1,3-oxazolidines as hydrolytically stable pseudoprolines.
Topics: Acylation; Esters; Fluorine; Methane; Molecular Structure; Oxazoles; Proline; Thiazoles | 2010 |
Synthesis of all-L cyclic tetrapeptides using pseudoprolines as removable turn inducers.
Topics: Models, Molecular; Molecular Conformation; Oligopeptides; Peptides, Cyclic; Proline; Stereoisomerism; Thiazoles | 2010 |
Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Hepacivirus; Humans; Leucine; Male; Microsomes, Liver; Oligopeptides; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Replicon; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins | 2010 |
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication | 2010 |
Proline periodicity modulates the self-assembly properties of elastin-like polypeptides.
Topics: Amyloid; Benzothiazoles; Elastin; Proline; Protein Multimerization; Protein Structure, Secondary; Thiazoles | 2010 |
Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cerebellum; Flow Cytometry; Humans; Lipopolysaccharides; Medulloblastoma; Neurons; NF-kappa B; Proline; Protein Array Analysis; Resveratrol; Signal Transduction; STAT3 Transcription Factor; Stilbenes; Tetrazolium Salts; Thiazoles; Thiocarbamates; Time Factors | 2011 |
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
Topics: Aminoisobutyric Acids; Carrier Proteins; Catalytic Domain; Clinical Trials, Phase I as Topic; Crystallography, X-Ray; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Proline; Protease Inhibitors; Protein Binding; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2011 |
Fragment condensation of C-terminal pseudoproline peptides without racemization on the solid phase.
Topics: Amino Acid Sequence; Microwaves; Molecular Sequence Data; Peptides; Proline; Ribonucleases; Stereoisomerism; Thiazoles | 2011 |
Synthesis and diuretic activities of pseudoproline-containing analogues of the insect kinin core pentapeptide.
Topics: Animals; Carboxylic Acids; Diuretics; Gastrointestinal Tract; Insecta; Kinins; Peptides; Proline; Protein Conformation; Thiazoles | 2011 |
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.
Topics: Absorption; Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Caco-2 Cells; Dogs; Drug Evaluation, Preclinical; Hepacivirus; Humans; Leucine; Macaca mulatta; Male; Microsomes, Liver; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution; Viral Nonstructural Proteins | 2012 |
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Crystallography, X-Ray; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Interferon-alpha; Kinetics; Leucine; Mutagenesis, Site-Directed; Mutation Rate; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Replicon; Thiazoles; Viral Nonstructural Proteins | 2012 |
Interferon-free treatment regimens for hepatitis C: are we there yet?
Topics: Aminoisobutyric Acids; Antiviral Agents; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Oligopeptides; Proline; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; Thiazoles | 2011 |
Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.
Topics: Histidine; Oxazoles; Proline; Protein Processing, Post-Translational; Proteins; Pyridines; Thiazoles; Tryptophan | 2012 |
New drugs 2012 part I.
Topics: Aminopyridines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzamides; Benzazepines; Benzimidazoles; Benzofurans; Ceftaroline; Cephalosporins; Cyclopropanes; Drug Approval; Drug Combinations; Humans; Imidazoles; Indoles; Isoindoles; Linagliptin; Lurasidone Hydrochloride; Macrolides; Oxadiazoles; Piperazines; Proline; Purines; Quinazolines; Thiazoles; United States; Vilazodone Hydrochloride | 2012 |
Local control of the cis-trans isomerization and backbone dihedral angles in peptides using trifluoromethylated pseudoprolines.
Topics: Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proline; Quantum Theory; Stereoisomerism; Thiazoles | 2012 |
Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
Topics: Amino Acids; Class I Phosphatidylinositol 3-Kinases; Class II Phosphatidylinositol 3-Kinases; Conserved Sequence; Dose-Response Relationship, Drug; Hydrazones; Isoenzymes; Kinetics; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proline; Protein Binding; Sulfonamides; Thiazoles | 2012 |
Properties of a proline-containing glass ionomer dental cement.
Topics: Acrylic Resins; Adsorption; Animals; Cariostatic Agents; Cell Line; Cell Proliferation; Cell Survival; Chemical Phenomena; Coloring Agents; Diffusion; Fluorides; Glass Ionomer Cements; Hardness; Materials Testing; Mice; Molecular Weight; Muscle Cells; Proline; Succinates; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Viscosity; Water | 2013 |
Incorporation of CF3-pseudoprolines into peptides: a methodological study.
Topics: Amides; Amino Acids; Fluorocarbons; Magnetic Resonance Spectroscopy; Molecular Conformation; Peptides; Proline; Thiazoles | 2013 |
Baseline hepatitis C virus (HCV) NS3 polymorphisms and their impact on treatment response in clinical studies of the HCV NS3 protease inhibitor faldaprevir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2014 |
Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.
Topics: Aminoisobutyric Acids; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Drug Stability; Drug Storage; Feces; Female; Hepatocytes; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Leucine; Male; Metabolic Clearance Rate; Microsomes; Oligopeptides; Proline; Protein Binding; Quinolines; Thiazoles | 2014 |
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.
Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Stability; Female; Fibroblasts; Glucuronides; Hepatocytes; Humans; Kinetics; Leucine; Liver; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Organic Anion Transporters; Proline; Quinolines; Sodium; Thiazoles | 2014 |
Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Bile; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Dose-Response Relationship, Drug; Drug Stability; Fibroblasts; Glucuronides; Hepacivirus; Hepatocytes; Leucine; Liver; Male; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Proline; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles | 2014 |
Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries.
Topics: Aminoisobutyric Acids; Anti-HIV Agents; Antiviral Agents; Carbamates; Developing Countries; Drug Industry; Drug Therapy, Combination; Health Services Accessibility; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine | 2014 |
Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors.
Topics: Antiviral Agents; Carbamates; Cloning, Molecular; Cyclopropanes; Drug Resistance, Viral; Escherichia coli; Gene Expression; Genetic Variation; Genotype; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Macrocyclic Compounds; Mutation; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Quinolines; Recombinant Proteins; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2014 |
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Topics: Catalytic Domain; Chromatography, High Pressure Liquid; Crystallization; Epoxide Hydrolases; Escherichia coli; Humans; Inflammation; Models, Molecular; Oligopeptides; Proline; Protein Conformation; Tandem Mass Spectrometry; Thiazoles; X-Ray Diffraction | 2014 |
Cysteine pseudoprolines for thiol protection and peptide macrocyclization enhancement in Fmoc-based solid-phase peptide synthesis.
Topics: Cyclization; Cysteine; Dipeptides; Molecular Structure; Proline; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds; Thiazoles | 2014 |
Definition of the binding mode of phosphoinositide 3-kinase α-selective inhibitor A-66S through molecular dynamics simulation.
Topics: Binding Sites; Class Ia Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Phosphoinositide-3 Kinase Inhibitors; Proline; Protein Binding; Thiazoles | 2014 |
A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants.
Topics: Antiviral Agents; Carbamates; Drug Resistance, Viral; Hepacivirus; Macrocyclic Compounds; Models, Statistical; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Protease Inhibitors; Quinolines; Replicon; RNA, Viral; Stochastic Processes; Thiazoles; Viral Nonstructural Proteins; Virus Replication | 2014 |
Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Interferons; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate | 2014 |
Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats.
Topics: Administration, Oral; Aminoisobutyric Acids; Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Injections, Intravenous; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles; Urine | 2014 |
The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Benzothiazoles; Cell Membrane; DNA-Binding Proteins; Glycine; Mice; Molecular Sequence Data; Mutant Proteins; Mutation; Peptides; Proline; Protein Aggregates; Protein Multimerization; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles; Time Factors | 2014 |
Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.
Topics: Antigens, Neoplasm; Membrane Proteins; Neoplasms; Peptides; Proline; Thiazoles | 2015 |
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cohort Studies; Female; Hepatitis C, Chronic; HIV Infections; Humans; Leucine; Male; Middle Aged; Oligopeptides; Patient Acceptance of Health Care; Proline; Prospective Studies; Protease Inhibitors; Quinolines; RNA, Viral; Switzerland; Thiazoles; Viral Load | 2015 |
Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy.
Topics: Aminoisobutyric Acids; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Polymers; Proline; Quinolines; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2016 |
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Disease Progression; ErbB Receptors; Female; Gallbladder Neoplasms; Humans; Male; Mice; Mice, Nude; Mutation; Neoplasm Invasiveness; Neoplasm Transplantation; Prognosis; Proline; Protein Binding; Signal Transduction; Survival Analysis; Thiazoles | 2016 |
Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir.
Topics: Acrylates; Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins | 2016 |
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.
Topics: Amides; Animals; Biological Availability; Class I Phosphatidylinositol 3-Kinases; Deuterium; Enzyme Inhibitors; Kinetics; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proline; Rats; Thiazoles; Urea | 2016 |
Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Binding Sites; Catalytic Domain; Codon; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Humans; Hydrogen Bonding; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Molecular Conformation; Mutation; Oligopeptides; Proline; Protein Binding; Quinolines; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2016 |
Sirtuin 1 Activation Reduces Transforming Growth Factor-β1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.
Topics: Acetylation; Anilides; Animals; Biopsy; Blood Pressure; Collagen; Disease Models, Animal; Disease Progression; Feeding Behavior; Fibrosis; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Heart Diseases; Heart Function Tests; HEK293 Cells; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Proline; Rats, Inbred F344; Renal Insufficiency, Chronic; RNA, Messenger; Sirtuin 1; Smad3 Protein; Thiazoles; Transforming Growth Factor beta1 | 2017 |
[Molecular recognition mechanism and motion of HCV NS3/4A protease with Faldaprevir analogue].
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Endopeptidases; Hepacivirus; Intracellular Signaling Peptides and Proteins; Leucine; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Serine Proteases; Thiazoles; Viral Nonstructural Proteins | 2016 |
Bypassing the proline/thiazoline requirement of the macrocyclase PatG.
Topics: Biocatalysis; Ligases; Proline; Substrate Specificity; Thiazoles | 2017 |
Homochiral versus Heterochiral Trifluoromethylated Pseudoproline Containing Dipeptides: A Powerful Tool to Switch the Prolyl-Amide Bond Conformation.
Topics: Amides; Dipeptides; Fluorine; Methylation; Molecular Structure; Proline; Stereoisomerism; Thiazoles | 2017 |
CF
Topics: Hydrogen Bonding; Methylation; Molecular Conformation; Peptides; Proline; Stereoisomerism; Thiazoles; Toluene | 2019 |
A Tripeptide Approach to the Solid-Phase Synthesis of Peptide Thioacids and N-Glycopeptides.
Topics: Acids; Amino Acid Sequence; Fluorenes; Glycopeptides; Oligopeptides; Proline; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds; Thiazoles | 2019 |
4-Methylpseudoproline analogues of cyclolinopeptide A: Synthesis, structural analysis and evaluation of their suppressive effects in selected immunological assays.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Circular Dichroism; Female; Humans; Immune System Diseases; Immunosuppressive Agents; Lymphocytes; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred CBA; Peptides, Cyclic; Proline; Sheep; Spleen; Structure-Activity Relationship; Thiazoles | 2020 |
Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis.
Topics: Acylation; Amino Acid Sequence; Amino Acids; Peptide Biosynthesis; Peptides; Proline; Protein Structure, Secondary; Solid-Phase Synthesis Techniques; Thiazoles | 2021 |
Effect of itraconazole on the pharmacokinetics of faldaprevir in healthy subjects.
Topics: Adult; Aminoisobutyric Acids; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Leucine; Male; Middle Aged; Proline; Quinolines; Thiazoles | 2021 |