proline has been researched along with telaprevir in 398 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 17 (4.27) | 29.6817 |
2010's | 377 (94.72) | 24.3611 |
2020's | 4 (1.01) | 2.80 |
Authors | Studies |
---|---|
Iino, S | 1 |
Chen, HJ; Chovan, LE; Dandliker, PJ; Guan, Z; Hernandez, L; Kempf, DJ; Klein, C; Klein, LL; Lau, YY; Marsh, KC; Randolph, JT; Turner, TM; Yeung, C | 1 |
Bes, M; Cubero, M; Esteban, JI; Esteban, R; Guardia, J; Otero, T; Quer, J; Sauleda, S | 1 |
Bogen, S; Chase, R; Girijavallabhan, V; Guo, Z; Njoroge, FG; Prongay, A; Ralston, R; Saksena, A; Skelton, A; Tong, X; Xia, E | 1 |
Kozal, MJ; Liu-Young, G | 1 |
Pár, A; Pár, G | 1 |
Gonzàlez-Candelas, F; López-Labrador, FX; Moya, A | 1 |
López-Labrador, FX | 1 |
Allen, TM; Berical, A; Berlin, AM; Bihl, F; Birch, C; Birren, BW; Carlson, J; Cerny, A; Chung, RT; Daar, ES; Donfield, SM; Edlin, BR; Fleckenstein, JF; Galagan, JE; Gomperts, ED; Heckerman, D; Henn, MR; Jacobson, IM; Kim, AY; Kleyman, M; Kodira, C; Koehrsen, M; Kuntzen, T; Lake-Bakaar, GV; Lauer, GM; Ledlie, T; Lee, B; Lennon, N; Liu, Z; Madey, MA; Marion, T; McMahon, CM; Nusbaum, C; Park, VM; Reyor, LL; Roberts, AD; Rosen, HR; Schneidewind, A; Schulze Zur Wiesch, J; Spengler, U; Talal, AH; Timm, J; Walker, BD; Xing, Y; Young, SK | 1 |
Kronenberger, B; Zeuzem, S | 3 |
Inoue, K; Watanabe, T; Yamada, M; Yoshiba, S | 1 |
Cullen, C; Curry, S; Greene, J; Guo, Z; Liu, S; Qiu, P; Ralston, R; Sanfiorenzo, V; Skelton, A; Tong, X; Xia, E | 1 |
Ciaramella, G; Corbau, R; Flores, MV; Strawbridge, J | 1 |
Domingues, FS; Herrmann, E; Hughes, E; Karey, U; Ralston, R; Sarrazin, C; Susser, S; Tong, X; Wang, Y; Welsch, C; Zettler, M; Zeuzem, S | 1 |
Nelson, DR | 2 |
El-Duweik, J; Farnik, H; Geisslinger, G; Lötsch, J; Sarrazin, C; Schmidt, H; Welsch, C; Zeuzem, S | 1 |
Back, D; Khoo, S; Seden, K | 1 |
Deshpande, M; Huang, M; Miller, MD; Mo, H; Murray, B; Qi, X; Rhodes, G; Sun, SC; Wang, K; Wang, Y; Yang, C | 1 |
Opar, A | 1 |
Antinori, S; Milazzo, L | 1 |
Rodríguez-Torres, M | 2 |
Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Kukolj, G; Lagacé, L; Llinàs-Brunet, M; Thibeault, D; White, PW | 1 |
Bae, A; Chen, X; Harris, J; Ku, K; Miller, MD; Mo, H; Qi, X; Sun, SC; Wong, KA; Worth, A | 1 |
Poordad, F | 1 |
Lange, CM; Sarrazin, C; Zeuzem, S | 1 |
Fried, MW | 1 |
Asselah, T; Marcellin, P | 2 |
Pawlotsky, JM | 1 |
Halfon, P; Locarnini, S | 1 |
Ciesek, S; Manns, MP | 1 |
Pockros, PJ | 1 |
Hofmann, WP; Zeuzem, S | 2 |
Enserink, M | 1 |
Imhof, I; Simmonds, P | 1 |
Aronsohn, A; Jensen, D | 1 |
Hunyady, B | 1 |
Barreiro, P; Fernandez-Montero, JV; Labarga, P; Martin-Carbonero, L; Poveda, E; Soriano, V; Vispo, E | 1 |
Gravitz, L | 1 |
Schlütter, J | 1 |
Rice, C | 1 |
Traynor, K | 2 |
Wood, NJ | 1 |
Bukh, J; Ghanem, L; Gottwein, JM; Jensen, TB; Scheel, TK | 1 |
Charlton, M | 1 |
Alcorn, MC; Dieterich, DT; Rabkin, JG; Weiss, JJ | 1 |
Sheridan, C | 1 |
Cabrera, R; Draganov, PV; Limaye, AR | 1 |
Corouge, M; Pol, S | 2 |
Chung, TL; Herrmann, E; Hofmann, WP; Karey, U; Lötsch, J; Mihm, U; Osbahr, C; Sarrazin, C; Susser, S; Welsch, C; Zeuzem, S | 1 |
Wapner, J | 1 |
Manns, M | 1 |
Back, D; Dieterich, D; Peters, M; Rockstroh, J; Sherman, KE; Soriano, V; Sulkowski, M | 1 |
Ilyas, JA; Vierling, JM | 2 |
Ciesek, S; Manns, MP; von Hahn, T | 1 |
Jazwinski, AB; Muir, AJ | 1 |
Dore, GJ; Matthews, GV; Rockstroh, J | 1 |
Ghany, MG; Nelson, DR; Seeff, LB; Strader, DB; Thomas, DL | 1 |
Bruno, R; Fagiuoli, S; Sacchi, P | 1 |
Forestier, N; Füller, C; Grigorian, N; Perner, D; Sarrazin, C; Susser, S; Vermehren, J; Welker, MW; Zeuzem, S | 1 |
Razonable, RR | 1 |
Goossens, N; Negro, F | 1 |
Stiefelhagen, P | 1 |
Back, D; Seden, K | 1 |
Rademacher, K; Schafer, JA; Tungol, A | 1 |
Spooner, LM | 1 |
Mutimer, DJ; Rowe, IA | 1 |
Harrington, PR; Naeger, LK; Zeng, W | 1 |
Battyáni, Z; Hunyady, B; Kovács, B | 1 |
Muir, AJ | 2 |
Carpio-Pedroza, JC; Cazares, F; Cruz-Rivera, MY; Escobar-Gutiérrez, A; Fonseca-Coronado, S; Rivera-Osorio, P; Ruíz-Pacheco, JA; Ruiz-Tovar, K; Vaughan, G; Vazquez-Pichardo, M | 1 |
Buti, M; Homs, M | 1 |
Iqbal, M; McCormick, PA | 1 |
Williams, SC | 1 |
Domingues, FS; Hartmann, C; Lemon, SM; Lengauer, T; Shimakami, T; Welsch, C; Yang, Y; Zeuzem, S | 1 |
Ferenci, P; Reddy, KR | 1 |
Butt, AA; Kanwal, F | 1 |
Gambarin-Gelwan, M; Jacobson, IM | 1 |
Bartlett, JG; Peters, MG; Pham, PA; Sherman, KE; Sulkowski, MS; Thomas, DL | 1 |
Hézode, C | 3 |
Kwo, PY | 1 |
Forestier, N; Zeuzem, S | 1 |
Bacon, BR; Khalid, O | 1 |
Esteban, R; Shiffman, ML | 1 |
Foster, GR; Serfaty, LD | 1 |
Adhoute, X; Benali, S; Bourlière, M; Castellani, P; Khaloun, A; Oules, V; Portal, I; Wartelle-Bladou, C | 1 |
Roche, B; Samuel, D | 1 |
Sulkowski, MS | 2 |
Mangia, A; Mottola, L | 1 |
Kumar, CK; Sarin, SK | 1 |
El Kassas, M; El Raziky, M; Esmat, G; Gamil, ME; Hassany, M | 1 |
Fried, MW; McGowan, CE | 1 |
Berg, T; Cornberg, M; Dollinger, M; Ferenci, P; Hinrichsen, H; Klinker, H; Kraus, M; Manns, M; Mauss, S; Peck-Radosavljevic, M; Sarrazin, C; Schmidt, H; Spengler, U; Wedemeyer, H; Wirth, S; Zeuzem, S | 1 |
Barreiro, P; Labarga, P; Poveda, E; Soriano, V; Vispo, E | 1 |
Fontaine, H; Pol, S | 1 |
Reinke, T | 1 |
Agarwal, K; Austin, A; Brown, A; Dillon, JF; Foster, GR; Fox, R; Fraser, A; Hayes, PC; Leen, C; Mills, PR; Mutimer, DJ; Ramachandran, P; Ryder, SD | 1 |
Hézode, C; Pawlotsky, JM; Sarrazin, C; Zeuzem, S | 1 |
Cheiab, B; Ioniţă-Radu, F; Raşcanu, A | 1 |
Anderson, PL; Burton, JR; Everson, GT; Kiser, JJ | 1 |
Crespo, G; Lens, S | 1 |
Gervain, J; Horváth, G; Hunyady, B; Makara, M; Pár, A; Szalay, F; Telegdy, L; Tornai, I; Ujhelyi, E | 1 |
Alkhouri, N; Zein, NN | 1 |
Hong, BA; Kerr, T; North, CS | 1 |
Afdhal, NH; Dusheiko, GM; Forns, X; Jacobson, IM; Jensen, DM; Pawlotsky, JM; Poordad, F; Schulz, J | 1 |
Domínguez Muñoz, E; Fernández Castroagudín, J; Molina Pérez, E | 1 |
Giordano, C | 1 |
Francque, S; Ho, E; Michielsen, P | 1 |
Fomsgaard, A; Gerstoft, J | 1 |
Beard, MR; Locarnini, SA; Thompson, AJ | 1 |
Bronte, F; Bruno, R; Cammà, C; Capursi, V; Cicchetti, A; Colombo, GL; Craxì, A; Di Marco, V; Enea, M; Gasbarrini, A; Petta, S | 1 |
Casey, LC; Lee, WM | 2 |
Saxena, V; Terrault, N | 1 |
Cacoub, P; Picard, O | 1 |
Jacobson, I; Jesudian, A; Welsch, C; Zeuzem, S | 1 |
Ford, JA; Greanya, E; Partovi, N; Wilby, KJ; Yoshida, EM | 1 |
Ingiliz, P; Rockstroh, JK | 1 |
McHutchison, JG; Thompson, AJ | 1 |
Erdmann, J | 1 |
Chang, MF; Lim, J; Monto, A; Morgan, TR; Pocha, C; Ross, D; Yee, HS | 1 |
Chevaliez, S; Pawlotsky, JM; Rodriguez, C | 1 |
Barritt, AS; Fried, MW | 1 |
Naggie, S; Sulkowski, MS | 1 |
Thompson, AJ | 1 |
Bruguera, M; Esteban, R; Forns, X; Planas, R; Quer, JC; Solà, R; Vergara, M | 1 |
Amur, S; Pacanowski, M; Zineh, I | 1 |
Perelson, AS; Ribeiro, RM; Rong, L | 1 |
Pearlman, BL | 1 |
Aghemo, A; Colombo, M; Degasperi, E | 1 |
Dybowska, D; Halota, W; Kozielewicz, D | 2 |
Fox, AN; Jacobson, IM | 1 |
Fadda, V; Maratea, D; Messori, A; Trippoli, S | 1 |
Assis, DN; Lim, JK | 1 |
Burton, MJ; McGuire, BM; Passarella, MJ | 1 |
Bourgeois, S; Colle, I; De Maeght, S; Deltenre, P; Delwaide, J; Francque, S; Laleman, W; Moreno, C; Mulkay, JP; Orlent, H; Reynaert, H; Stärkel, P | 1 |
Bourlière, M; Bronowicki, JP; Delasalle, P; Leroy, V; Pageaux, GP; Pariente, A; Pol, S; Serfaty, L; Zoulim, F | 1 |
Ali, A; Aydin, C; Cao, H; Deveau, LM; Huang, W; Newton, A; Ozen, A; Petropoulos, CJ; Romano, KP; Schiffer, CA; Silver, C; Soumana, D | 1 |
Grammatikos, G; Vermehren, J; Zeuzem, S | 1 |
Boesecke, C; Rockstroh, JK | 1 |
Dusheiko, G; Wedemeyer, H | 1 |
Bianic, F; Cure, S; Diels, J; Gavart, S; Jones, E | 1 |
Ouzan, D | 1 |
Chandy, GM; Conjeevaram, H; Jothimani, D | 1 |
Pascale, A; Serfaty, L | 1 |
Barry, M; Bergin, C; Kieran, J; Norris, S; O'Leary, A; Schmitz, S; Walsh, C | 1 |
Flemming, JA; Terrault, NA | 1 |
Barreiro, P; Fernández-Montero, JV; Labarga, P; Soriano, V; Vispo, E | 1 |
Deltenre, P; Moreno, C | 1 |
Bárcena, R; Casado, JL; Del Campo, S; Dronda, F; Mateos, ML; Montes, M; Moreno, A; Moreno, S; Pérez-Elías, MJ; Quereda, C; Rodríguez-Sagrado, MA | 1 |
Barreiro, P; Benito, JM; Fernández-Montero, JV; Labarga, P; Poveda, E; Rallon, N; Sánchez, C; Soriano, V; Vispo, E | 1 |
Asselah, T | 2 |
Cooper, C; Druyts, E; El Khoury, AC; Lester, R; Mills, EJ; Thorlund, K; Yaya, S | 1 |
Carlson, A; Gregorich, Z; Striker, R | 1 |
Burton, JR; Everson, GT | 1 |
de Knegt, RJ; Janssen, HL; Pan, Q; Peppelenbosch, MP | 1 |
Barrantes-González, M; González-Colominas, E; Salas, E; Solà, R | 1 |
Gellad, ZF; Muir, AJ; Reed, SD | 1 |
Gane, E | 1 |
Jacobson, IM; Marks, KM | 1 |
Lemon, M | 1 |
Boonstra, A; Janssen, HL; Spaan, M | 1 |
Buti, M; Esteban, R | 1 |
Sarrazin, C; Vermehren, J | 1 |
Abu-Mouch, S; Baruch, Y; Ben-Ari, Z; Bruck, R; Kaspa, RT; Lurei, Y; Oren, R; Safadi, R; Shibolet, O; Shouval, D; Zuckerman, E | 1 |
Aronsohn, A; Jensen, D; Muir, AJ; Swan, T | 1 |
Harrington, PR; Lontok, E; Mani, N; Miller, V | 1 |
Comee, MK; Malloy, M; Silva, M; Sitole, M; Spooner, L | 1 |
Cornberg, M; Kirschner, J; Maasoumy, B; Manns, MP; Markova, AA; Mix, C; Port, K; Rogalska-Taranta, M; Serrano, BC; Sollik, L; Wedemeyer, H | 1 |
Heil, EL; Hynicka, LM | 1 |
Barnard, RJ; Chase, R; Curry, S; Frontera, MJ; Graham, DJ; Gupta, S; Howe, AY; Howe, JA; Hughes, E; Lahser, F; McMonagle, P; Silva, MO; Treitel, M | 1 |
Fried, MW; Jensen, DM | 1 |
Birnkrant, D; Carter, W; Chen, J; Fleischer, RD; Florian, J; Hammerstrom, TS; Jadhav, PR; Murray, J; Zeng, W | 1 |
Nikitin, AV | 1 |
Agnesod, D; Boglione, L; Cariti, G; D'Avolio, A; De Nicolò, A; Di Perri, G; Dilly Penchala, S; Mohamed Abdi, A; Simiele, M | 1 |
Backus, LI; Belperio, PS; Cheung, RC; Hwang, EW; Mole, LA; Thomas, IC | 1 |
Bota, S; Neghină, AM; Popescu, A; Şirli, R; Sporea, I; Străin, M | 1 |
Cobb, B; Pockros, PJ; Vierling, JM; Vilchez, RA | 1 |
Ahmed, F | 1 |
de Jong, YP; Jacobson, IM; Jesudian, AB | 1 |
Aguilera, V; Berenguer, M; Vinaixa, C | 1 |
Apica, B; Chen, EY; Czul, F; Dubin, P; Lee, WM; Martin, P; Sclair, SN | 1 |
Bazin-Karra, D; Blanc, F; Cacoub, P; Cazorla, C; Decaux, O; Karras, A; Lambotte, O; Longuet, M; Musset, L; Pialoux, G; Pol, S; Resche Rigon, M; Saadoun, D; Thibault, V; Vittecoq, D; Ziza, JM | 1 |
Aouri, M; Buclin, T; Cavassini, M; Csajka, C; Decosterd, LA; Mercier, T; Moradpour, D; Rauch, A; Telenti, A | 1 |
Aguilera, A; Barreiro, P; Benito, JM; Fernández-Montero, JV; Labarga, P; Maida, I; Rallón, NI; Rick, F; Sánchez-Parra, C; Soriano, V | 1 |
Crespo, G; Forns, X; Londoño, MC | 1 |
Abergel, A; Alric, L; Attali, P; Barthe, Y; Bernard, PH; Bourlière, M; Bronowicki, JP; Cacoub, P; Canva, V; Carrat, F; Causse, X; Dao, T; de Ledinghen, V; Di Martino, V; Dorival, C; Feray, C; Fontaine, H; Grando-Lemaire, V; Guyader, D; Hézode, C; Hillon, P; Larrey, D; Loustaud-Ratti, V; Lucidarme, D; Marcellin, P; Métivier, S; Pawlotsky, JM; Petrov-Sanchez, V; Pol, S; Poynard, T; Raabe, JJ; Riachi, G; Rosa, I; Samuel, D; Serfaty, L; Tran, A; Zarski, JP; Zoulim, F | 1 |
Dolton, MJ; McLachlan, AJ; Ray, JE | 1 |
Giguere, P; Sockalingam, S; Tseng, A; Wong, D | 1 |
Aqel, BA; Charlton, MR; Henry, TM; Keaveny, AP; Koning, L; Murphy, JL; Pungpapong, S; Rosser, BG; Ryland, KL; Satyanarayana, R; Vargas, HE; Yataco, ML | 1 |
Asch, SM; Chan, K; Clark, JA; Gifford, AL; Groessl, EJ; Hanchate, AD; Ho, SB; Lai, MN; Wong, JB | 1 |
Alberti, A; Bruno, R; Cabibbo, G; Cammà, C; Capursi, V; Craxì, A; Enea, M; Gasbarrini, A; Petta, S; Ruggeri, M | 1 |
Gunson, RN; Leitch, EC; McNaughton, AL; Templeton, K; Thomson, EC | 1 |
Biesbroeck, LK; Falsey, RR; Moore, E; Scott, JD; Shinohara, MM; Taraska, C | 1 |
Taylor, DR | 1 |
Alshuth, U; Hueppe, D; Mauss, S | 1 |
Corouge, M; Mallet, V; Pol, S; Sogni, P | 1 |
Brown, J; Paladino, JA; Turner, SJ | 1 |
Andonov, A; Kadkhoda, K; Kaita, K; Osiowy, C | 1 |
Klinker, H; Mauss, S | 1 |
Urbánek, P | 1 |
Euliano, R; Juneja, M; Lewis, JH; Satoskar, R | 1 |
Bublak, R | 1 |
Blázquez-Pérez, A; Mar, J; San Miguel, R | 1 |
Bianic, F; Cure, S; Curtis, S; Dusheiko, G; Gavart, S; Lee, S | 1 |
Boucher, CA; Broekman, MM; Brouwer, JT; Burger, DM; de Knegt, RJ; Drenth, JP; Hoepelman, AI; Lamers, MH; Reesink, HW; van Hoek, B | 1 |
Akiyama, MJ; Chan, SM; Hong, LK; Huddleston, L; Piotrowski, JI; Roytman, MM; Trujillo, R; Tsai, NC | 1 |
Bañares, R; Fernández-Yunquera, A; Rincón, D; Salcedo, M | 1 |
Serfaty, L | 1 |
Back, D; Else, L | 1 |
Agarwal, K; Barnabas, A | 1 |
Chiari, E; Cocca, G; Moioli, MC; Morreale, M; Orso, M; Panzeri, C; Puoti, M; Rossotti, R; Travi, G | 1 |
Colombo, M; D'Ambrosio, R | 1 |
Aghemo, A; Bitetto, D; Bruno, R; Caraceni, P; Ciancio, A; Coco, B; Marzioni, M; Petta, S; Rendina, M; Valenti, L | 1 |
Galle, PR; Grambihler, A; Kittner, JM; Koch, S; Schattenberg, JM; Schuchmann, M; Thieringer, F; Weinmann, A; Weiss, NM; Wiltink, J; Zimmermann, T | 1 |
Calle Serrano, B; Cornberg, M; Maasoumy, B; Manns, MP; Markova, AA; Port, K; Sollik, L; Wedemeyer, H | 1 |
Bichoupan, K; Dieterich, DT; Martel-Laferrière, V | 1 |
Lim, TR; Mutimer, DJ; Tan, BH | 1 |
Antinori, S; Cattaneo, D; Falvella, FS; Gervasoni, C; Magni, C; Milazzo, L; Peri, AM; Vidale, S | 1 |
Liu, CJ | 1 |
Backus, LI; Belperio, PS; Cheung, R; Mole, LA; Shahoumian, TA | 1 |
Jiang, S; Lawson, KA; Park, C | 1 |
Bukh, J; Gottwein, JM; Humes, D; Jensen, SB; Li, YP; Ramirez, S | 1 |
Alberti, A; Colombo, M; Craxì, A; Rizzetto, M | 1 |
Fontana, RJ; Tischer, S | 1 |
Pol, S | 1 |
Baka, M; Dyda, T; Opoka-Kegler, J; Stańczak, GP; Stańczak, JJ; Zabek, P | 1 |
Fang, A; Heera, J; Kantaridis, C; Plotka, A; Vourvahis, M | 1 |
Beste, LA; Green, PK; Ioannou, GN | 2 |
Adhoute, X; Ansaldi, C; Bourlière, M; Castellani, P; Oules, V; Wendt, A | 1 |
Boccaccio, V; Bruno, S | 1 |
Coilly, A; Duclos-Vallée, JC; Roche, B; Samuel, D | 2 |
Dieterich, DT; Martel-Laferrière, V | 1 |
Cybula, M; Szemraj, J | 1 |
Geier, A | 1 |
Gil-Gómez, I; Lorente-Fernández, L; Marrero-Álvarez, P; Monte-Boquet, E; Poveda-Andrés, JL | 1 |
Calleja Hernández, MÁ; Fernández-López, C; García Collado, C; Jiménez Morales, A; López-Sepúlveda, R; Valencia Soto, C | 1 |
Anwar, MI; Danielson, UH; Ehrenberg, AE; Gustafsson, SS; Schmuck, B; Stenberg, G | 1 |
Booth, CL; Bridge, SH; Dusheiko, G; Garcia-Diaz, A; Haque, T; Irish, D; Jacobs, M; Labbett, W; Macartney, MJ; McCormick, AL; Rosenberg, W; Smith, C; Tanwar, S; Trembling, P; Velazquez, C | 1 |
Gutierrez, JA; Wyles, DL | 1 |
El-Serag, HB; Kanwal, F | 1 |
Amiri, M; Bailly, F; Funingana, G; Gonçalves, F; Hartig-Lavie, K; Maynard, M; Pradat, P; Virlogeux, V; Zoulim, F | 1 |
Chung, RT; deLemos, AS | 1 |
Akberdin, IR; Clausznitzer, D; Demenkov, PS; Gursky, VV; Ivanisenko, NV; Ivanisenko, VA; Kaderali, L; Kolchanov, NA; Kozlov, KN; Likhoshvai, VA; Mishchenko, EL; Samsonov, AM; Samsonova, MG; Todorov, DI | 1 |
Canva, V; Deltenre, P; Deuffic-Burban, S; Dhumeaux, D; Larrey, D; Mallet, V; Mathurin, P; Obach, D; Pageaux, GP; Pol, S; Roudot-Thoraval, F; Schwarzinger, M; Yazdanpanah, Y | 1 |
Andronescu, CI; Andronescu, D; Diaconu, S; Purcarea, RM; Tiuca, N | 1 |
Catalli, L; Chua, J; Manos, MM; Monto, A; Murphy, RC; Pauly, MP; Saxena, V; Shvachko, VA; Terrault, NA; Wayne, E; Yee, HS | 1 |
Sogni, P | 1 |
Backus, LI; Belperio, PS; Mole, LA; Shahoumian, TA | 1 |
Bruno, R; Cabibbo, G; Cammà, C; Craxì, A; Enea, M; Gasbarrini, A; Macaluso, FS; Petta, S; Plaia, A | 1 |
Abergel, A; Alric, L; Attali, P; Barthe, Y; Bernard, PH; Bourliere, M; Bronowicki, JP; Cacoub, P; Canva, V; Carrat, F; Causse, X; Chazouilleres, O; Dao, T; De Ledinghen, V; Di Martino, V; Dorival, C; Fontaine, H; Fontanges, T; Gournay, J; Grando-Lemaire, V; Guyader, D; Hézode, C; Hillon, P; Larrey, D; Loustaud-Ratti, V; Lucidarme, D; Marcellin, P; Metivier, S; Pawlotsky, JM; Petrov-Sanchez, V; Pol, S; Portal, I; Poynard, T; Raabe, JJ; Riachi, G; Rosa, I; Samuel, D; Tran, A; Zarski, JP; Zoulim, F | 1 |
Arends, JE; Burger, DM; de Kanter, CT; de Knegt, RJ; Drenth, JP; Reesink, HW; van der Valk, M | 1 |
Angelillo, IF; Coppola, N; Pisaturo, M; Sagnelli, C; Sagnelli, E | 1 |
Gimeno-Ballester, V; Mar, J; San Miguel, R | 1 |
Aichelburg, MC; Boesecke, C; Lang, G; Mandorfer, M; Niederecker, A; Payer, BA; Peck-Radosavljevic, M; Reiberger, T; Rieger, A; Strassl, R; Trauner, M | 1 |
Brown, RS; Burton, JR; Dodge, JL; Everson, GT; Levitsky, J; O'Leary, JG; Saxena, V; Stravitz, RT; Terrault, NA; Trotter, JF; Verna, EC | 2 |
Berg, T; Buggisch, P; Buslau, A; Hinrichsen, H; Maasoumy, B; Sarrazin, C; Schiefke, I; Wedemeyer, H; Wiegand, J | 1 |
Abergel, A; Boyer, A; Lamblin, G; Sautou, V; Talavera Pons, S | 1 |
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Goncales, ES; Goncales, FL; Lazarini, MS; Mendes, LC; Miotto, N; Pedro, MN; Stucchi, RS; Vigani, AG; Zanaga, LP | 1 |
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Carr, M; De Gascun, CF; Gray, E; Nguyen, LT; O'Leary, A | 1 |
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147 review(s) available for proline and telaprevir
Article | Year |
---|---|
[Drugs for hepatitis B and C infection].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Mutation; Oligopeptides; Organophosphonates; Proline; Ribavirin; Serine Proteinase Inhibitors | 2007 |
Hepatitis C protease and polymerase inhibitors in development.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C; HIV Infections; Humans; Multicenter Studies as Topic; Oligopeptides; Proline; Protease Inhibitors; Pyrimidine Nucleosides; Randomized Controlled Trials as Topic | 2008 |
Hepatitis C Virus NS3/4A Protease Inhibitors.
Topics: Antiviral Agents; Drug Resistance, Viral; Hepacivirus; Oligopeptides; Proline; Viral Nonstructural Proteins | 2008 |
Future treatment options for HCV: double, triple, what is the optimal combination?
Topics: Antiviral Agents; Cytidine; DNA-Directed RNA Polymerases; Drug Delivery Systems; Drug Resistance, Viral; Drug Therapy, Combination; Forecasting; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Nucleosides; Oligopeptides; Polyethylene Glycols; Prodrugs; Proline; Protease Inhibitors; Pyrimidine Nucleosides; Recombinant Proteins; Ribavirin | 2008 |
[Novel treatment for chronic hepatitis C in near future].
Topics: Drug Delivery Systems; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2009 |
[Future of antiviral therapy for chronic hepatitis C. Direct antiviral acting medications].
Topics: Antiviral Agents; Clinical Trials, Phase II as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Proline; Protease Inhibitors; Viral Nonstructural Proteins; Virus Replication | 2011 |
The role of triple therapy with protease inhibitors in hepatitis C virus genotype 1 naïve patients.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2011 |
New direct-acting antivirals' combination for the treatment of chronic hepatitis C.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Signal Transduction; Standard of Care; Virus Replication | 2011 |
Hepatitis C virus resistance to protease inhibitors.
Topics: Antiviral Agents; Drug Resistance, Viral; Genes, Viral; Hepacivirus; Hepatitis C, Chronic; Host-Pathogen Interactions; Humans; Liver; Models, Molecular; Mutation; Oligopeptides; Proline; Protease Inhibitors; Viral Nonstructural Proteins; Virus Replication | 2011 |
Hepatitis in 2010: the dawn of a new era in HCV therapy.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2011 |
A new standard of care for the treatment of chronic HCV infection.
Topics: Antiviral Agents; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Oligopeptides; Pharmacogenetics; Proline; Standard of Care; Treatment Outcome; United States | 2011 |
[New therapeutic options in chronic hepatitis C virus infection].
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome | 2011 |
Directly acting antivirals against hepatitis C virus.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Discovery; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline | 2011 |
New treatments for chronic hepatitis C virus infection.
Topics: Antiviral Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Compassionate Use Trials; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Molecular Targeted Therapy; Oligopeptides; Polyethylene Glycols; Proline; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; RNA-Dependent RNA Polymerase; Serine Proteinase Inhibitors; Therapies, Investigational | 2011 |
Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C virus-co-infected patients.
Topics: Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Coinfection; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2011 |
An overview of emerging therapies for the treatment of chronic hepatitis C.
Topics: Antiviral Agents; Clinical Trials as Topic; Cyclophilins; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Viral Nonstructural Proteins | 2011 |
Second-wave protease inhibitors: choosing an heir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2011 |
Emerging therapies in hepatitis C: dawn of the era of the direct-acting antivirals.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Hepacivirus; Hepatitis C, Chronic; Humans; Nucleosides; Oligopeptides; Proline; Serine Proteinase Inhibitors; Viral Nonstructural Proteins | 2011 |
Future of hepatitis C therapy: development of direct-acting antivirals.
Topics: Antiviral Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Oligopeptides; Proline; Protease Inhibitors; Treatment Outcome | 2011 |
Antiviral drugs for viruses other than human immunodeficiency virus.
Topics: Acyclovir; Adenine; Amantadine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Foscarnet; Ganciclovir; Guanine; Hepatitis; Hepatitis B, Chronic; Hepatitis C; Herpesviridae Infections; HIV Infections; Humans; Influenza, Human; Interferons; Lamivudine; Nucleosides; Oligopeptides; Organophosphonates; Oseltamivir; Proline; Protease Inhibitors; Pyrimidinones; Ribavirin; Telbivudine; Thymidine; Valacyclovir; Valganciclovir; Valine; Virus Replication; Zanamivir | 2011 |
Directly acting antivirals for hepatitis C and antiretrovirals: potential for drug-drug interactions.
Topics: Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Oligopeptides; Proline; Protease Inhibitors | 2011 |
Formulary management of the protease inhibitors boceprevir and telaprevir for chronic hepatitis C virus.
Topics: Adolescent; Adult; Aged; Algorithms; Clinical Trials, Phase III as Topic; Drug Costs; Female; Hepatitis C, Chronic; Humans; Male; Managed Care Programs; Middle Aged; Oligopeptides; Patient Compliance; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; RNA, Viral; Viral Load; Young Adult | 2011 |
Protease inhibitors for treatment of genotype 1 hepatitis C virus infection.
Topics: Cost-Benefit Analysis; Drug Interactions; Drug Monitoring; Genotype; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic | 2011 |
[Side-effects of pegylated interferon plus ribavirin therapy with or without protease inhibitor direct acting antiviral agents during treatment of chronic hepatitis C virus infection].
Topics: Affect; Anemia, Hypochromic; Antiviral Agents; Autoimmune Diseases; Autoimmunity; Cardiovascular System; Clinical Trials as Topic; Drug Eruptions; Drug Synergism; Drug Therapy, Combination; Endocrine System Diseases; Eye; Hepatitis C, Chronic; Humans; Infections; Interferon alpha-2; Interferon-alpha; Neutropenia; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Respiratory System; Ribavirin; Risk Factors; Thrombocytopenia | 2011 |
Telaprevir for the treatment of chronic hepatitis C infection.
Topics: Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Mutation; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; Viral Nonstructural Proteins | 2011 |
[New agents for the treatment of hepatitis C].
Topics: Anemia; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Discovery; Drug Eruptions; Drugs, Investigational; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Molecular Targeted Therapy; Multicenter Studies as Topic; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Spain; Viral Nonstructural Proteins | 2012 |
Impact of HCV protease-inhibitor-based triple therapy for chronic HCV genotype 1 infection.
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; Treatment Outcome; Viral Load | 2011 |
Boceprevir and telaprevir in the management of hepatitis C virus-infected patients.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferons; Oligopeptides; Proline; Ribavirin; Treatment Outcome | 2012 |
Resistance-associated variants in chronic hepatitis C patients treated with protease inhibitors.
Topics: Drug Resistance, Viral; Genetic Variation; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2012 |
Hepatitis C in 2011: A new standard of care and the race towards IFN-free therapy.
Topics: Antiviral Agents; Contraindications; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Randomized Controlled Trials as Topic; Recombinant Proteins; RNA, Viral; Standard of Care | 2011 |
Boceprevir and telaprevir for the treatment of chronic hepatitis C: safety management in clinical practice.
Topics: Anemia; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Skin Diseases; Withholding Treatment | 2012 |
Phase III results in Genotype 1 naïve patients: predictors of response with boceprevir and telaprevir combined with pegylated interferon and ribavirin.
Topics: Adult; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Ethnicity; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indiana; Interferon-alpha; Interferons; Interleukins; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Serine Proteinase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2012 |
Triple therapy with telaprevir: results in hepatitis C virus-genotype 1 infected relapsers and non-responders.
Topics: Adult; Aged; Anemia; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Serine Proteinase Inhibitors; Skin Diseases; Treatment Failure; Treatment Outcome; Virus Replication; Young Adult | 2012 |
Triple therapy with boceprevir for HCV genotype 1 infection: phase III results in relapsers and nonresponders.
Topics: Anemia; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Substitution; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Serine Proteinase Inhibitors; Skin Diseases; Standard of Care; Treatment Failure | 2012 |
Triple therapy for HCV genotype 1 infection: telaprevir or boceprevir?
Topics: Algorithms; Anemia; Antiviral Agents; Clinical Protocols; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Skin Diseases; Time Factors; Viral Load | 2012 |
Triple combination treatment for chronic hepatitis C with protease inhibitors, pegylated interferon and ribavirin: 'lead-in or no lead-in'?
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2012 |
Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow.
Topics: Antiviral Agents; Disease Eradication; Drug Administration Schedule; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Time Factors; Treatment Outcome | 2012 |
Future treatment of patients with HCV cirrhosis.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Serine Proteinase Inhibitors; Viral Load | 2012 |
Hepatitis C virus treatment pre- and post-liver transplantation.
Topics: Antiviral Agents; Disease Progression; Drug Administration Schedule; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Liver Transplantation; Oligopeptides; Polyethylene Glycols; Postoperative Complications; Proline; Recombinant Proteins; Recurrence; Ribavirin; Serine Proteinase Inhibitors; Time Factors; Viral Load | 2012 |
Hepatitis C virus-human immunodeficiency virus coinfection.
Topics: Antiviral Agents; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Male; Oligopeptides; Patient Selection; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Treatment Failure; Treatment Outcome; Viral Load | 2012 |
What's new in HCV genotype 2 treatment.
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Interleukins; Liver Cirrhosis; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Sofosbuvir; Treatment Outcome; Uridine Monophosphate; Viral Load | 2012 |
Treatment of patients with genotype 3 chronic hepatitis C--current and future therapies.
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Time Factors; Viral Load | 2012 |
The future for the treatment of genotype 4 chronic hepatitis C.
Topics: Albumins; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Nitro Compounds; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Thiazoles; Time Factors; Viral Load; Vitamin D | 2012 |
Barriers to hepatitis C treatment.
Topics: Antiviral Agents; Drug Therapy, Combination; Health Services Accessibility; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Treatment Refusal; Viral Load | 2012 |
[Expert opinion on boceprevir- and telaprevir-based triple therapies of chronic hepatitis C].
Topics: Antiviral Agents; Drug Therapy, Combination; Germany; Hepatitis C, Chronic; Humans; Oligopeptides; Practice Guidelines as Topic; Proline; Protease Inhibitors | 2012 |
Treatment failure with new hepatitis C drugs.
Topics: Antiviral Agents; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Phenotype; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Treatment Failure | 2012 |
Antiviral activity of telaprevir and boceprevir for the treatment of hepatitis C virus infection in treatment-experienced patients.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins | 2011 |
Antiviral strategies in hepatitis C virus infection.
Topics: Antiviral Agents; Cyclophilins; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA-Dependent RNA Polymerase; Viral Nonstructural Proteins | 2012 |
IL28B polymorphism -- predictive factor of HCV infected genotype 1 individuals to treatment response and management of therapy.
Topics: Antiviral Agents; Biomarkers; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Predictive Value of Tests; Proline; Recombinant Proteins; Ribavirin; Risk Assessment; Sensitivity and Specificity; Treatment Outcome | 2011 |
Review and management of drug interactions with boceprevir and telaprevir.
Topics: Anti-Retroviral Agents; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Male; Oligopeptides; Proline; Risk Assessment; Treatment Outcome | 2012 |
Treatment of chronic hepatitis C genotype 1 with triple therapy comprising telaprevir or boceprevir.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors; RNA, Viral; Treatment Outcome | 2012 |
Protease inhibitors: silver bullets for chronic hepatitis C infection?
Topics: Antiviral Agents; Chronic Disease; Drug Therapy, Combination; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins | 2012 |
Hepatitis C and substance use: new treatments and novel approaches.
Topics: Antiviral Agents; Attitude of Health Personnel; Drug Therapy, Combination; Health Services Accessibility; Hepatitis C; Humans; Oligopeptides; Proline; Protease Inhibitors; Substance-Related Disorders | 2012 |
A practical guide for the use of boceprevir and telaprevir for the treatment of hepatitis C.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Oligopeptides; Practice Guidelines as Topic; Proline; Protease Inhibitors; Viremia | 2012 |
Does antiviral therapy reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis C?
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Europe; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Liver Neoplasms; North America; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Risk Assessment; Treatment Outcome; Viral Load | 2012 |
Resistance to anti-HCV protease inhibitors.
Topics: Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Models, Molecular; Oligopeptides; Proline; Protease Inhibitors; Viral Nonstructural Proteins; Virus Replication | 2011 |
Hepatitis C therapy update.
Topics: Anemia; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Risk Factors | 2012 |
Hepatitis C virus treatment and liver transplantation in the era of new antiviral therapies.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon Type I; Liver Transplantation; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin | 2012 |
Dermatological adverse effects during genotype-1 hepatitis C treatment with the protease inhibitors telaprevir and boceprevir. Patient management.
Topics: Drug Eruptions; Genotype; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Protease Inhibitors | 2012 |
New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Serine Proteinase Inhibitors | 2012 |
Review of boceprevir and telaprevir for the treatment of chronic hepatitis C.
Topics: Antiviral Agents; Disease Management; Disease Progression; Drug Interactions; Drug Therapy, Combination; Genome, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Standard of Care; Treatment Outcome; Viral Load | 2012 |
HIV-HCV co-infection facing HCV protease inhibitor licensing: implications for clinicians.
Topics: Coinfection; Drug Interactions; Hepatitis C, Chronic; HIV Infections; Humans; Oligopeptides; Proline; Serine Proteinase Inhibitors | 2012 |
Will IL28B polymorphism remain relevant in the era of direct-acting antiviral agents for hepatitis C virus?
Topics: Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Delivery Systems; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Male; Oligopeptides; Polymorphism, Genetic; Proline; Treatment Outcome | 2012 |
New virologic tools for management of chronic hepatitis B and C.
Topics: Antiviral Agents; Clinical Trials as Topic; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Genome, Viral; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C Antigens; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Point-of-Care Systems; Polyethylene Glycols; Proline; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Ribavirin; RNA, Viral; Sequence Analysis, DNA; Treatment Outcome | 2012 |
Maximizing opportunities and avoiding mistakes in triple therapy for hepatitis C virus.
Topics: Anemia, Hypochromic; Antiviral Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Eruptions; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Tract; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Treatment Outcome | 2012 |
Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Coinfection; Deoxycytidine; Dideoxynucleosides; Disease Progression; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Hepatitis C, Chronic; HIV Infections; Homosexuality, Male; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Diseases; Male; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Pyrrolidinones; Raltegravir Potassium; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Substance Abuse, Intravenous; Tenofovir; Treatment Outcome | 2012 |
Protease inhibitors for the treatment of chronic hepatitis C genotype-1 infection: the new standard of care.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Standard of Care; United States | 2012 |
Directly acting antivirals for the treatment of chronic hepatitis C: unresolved topics from registration trials.
Topics: Antiviral Agents; Genotype; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Oligopeptides; Practice Guidelines as Topic; Proline; Protease Inhibitors; Treatment Outcome | 2013 |
[Efficacy of triple therapy in patients with chronic hepatitis C not treated and patients previously treated ineffectively].
Topics: Antiviral Agents; Carrier Proteins; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Europe; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Oligopeptides; Poland; Proline; Ribavirin; Serine Proteinase Inhibitors; Treatment Outcome; Viral Nonstructural Proteins | 2012 |
New pharmacotherapy for hepatitis C.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Liver; Oligopeptides; Proline | 2012 |
Protease inhibitor-based triple therapy in chronic hepatitis C: guidelines by the French Association for the Study of the Liver.
Topics: Antiviral Agents; Drug Combinations; France; Genotype; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Time Factors | 2012 |
[Chronic hepatitis C: improved cure rates with new approved medications].
Topics: Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drugs, Investigational; Genotype; Guideline Adherence; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2012 |
Efficacy of telaprevir and boceprevir in treatment-naïve and treatment-experienced genotype 1 chronic hepatitis C patients: an indirect comparison using Bayesian network meta-analysis.
Topics: Antiviral Agents; Bayes Theorem; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Randomized Controlled Trials as Topic | 2012 |
A new era in the treatment of chronic hepatitis C infection.
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2013 |
The relative efficacy of boceprevir and telaprevir in the treatment of hepatitis C virus genotype 1.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Recurrence; Treatment Outcome | 2013 |
[Management of chronic hepatitis C in 2012 in Belgium].
Topics: Antiviral Agents; Belgium; Drug Combinations; Drug Interactions; Hepatitis C, Chronic; Humans; Models, Biological; Oligopeptides; Proline | 2012 |
Interferon stimulated genes and hepatitis C virus infection.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Fibrosis; Gene Expression Regulation; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Liver; Oligopeptides; Polyethylene Glycols; Polymorphism, Single Nucleotide; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Viral Nonstructural Proteins | 2012 |
Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis.
Topics: Antiviral Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Comparative Effectiveness Research; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Oligopeptides; Polyethylene Glycols; Proline; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; Treatment Outcome | 2013 |
Management of the transplant recipient with chronic hepatitis C.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Immunocompromised Host; Immunosuppressive Agents; Interferons; Liver Transplantation; Oligopeptides; Polyethylene Glycols; Postoperative Care; Preoperative Care; Proline; Ribavirin; Serine Proteinase Inhibitors | 2013 |
Telaprevir/boceprevir era: from bench to bed and back.
Topics: Animals; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Translational Research, Biomedical; Treatment Outcome | 2012 |
Economic evaluation of direct-acting antiviral therapy in chronic hepatitis C.
Topics: Antiviral Agents; Cost of Illness; Cost-Benefit Analysis; Decision Support Techniques; Drug Therapy, Combination; Europe; Hepacivirus; Hepatitis C, Chronic; Humans; Models, Economic; Oligopeptides; Proline; Treatment Outcome; United States | 2012 |
Future perspectives: towards interferon-free regimens for HCV.
Topics: Administration, Oral; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Proline; Ribavirin; Treatment Outcome | 2012 |
The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir.
Topics: Algorithms; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Serine Proteinase Inhibitors; Viral Nonstructural Proteins | 2012 |
Immunology of hepatitis C virus infections.
Topics: Adaptive Immunity; Antiviral Agents; Dendritic Cells; Hepacivirus; Hepatitis C, Chronic; Humans; Immunity, Innate; Killer Cells, Natural; Liver; Oligopeptides; Proline; T-Lymphocytes | 2012 |
Triple therapy with boceprevir or telaprevir for treatment naïve HCV patients.
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2012 |
The role of resistance in HCV treatment.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Microbial Sensitivity Tests; Molecular Targeted Therapy; Mutation; Oligopeptides; Proline; Protease Inhibitors; Ribavirin | 2012 |
IL28B in the era of direct-acting antivirals for hepatitis C.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Interleukins; Oligopeptides; Proline; Time Factors; Treatment Outcome | 2013 |
Telaprevir versus boceprevir in chronic hepatitis C: a meta-analysis of data from phase II and III trials.
Topics: Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin | 2013 |
Anemia management in patients with chronic viral hepatitis C.
Topics: Anemia; Antiviral Agents; Drug Monitoring; Drug Therapy, Combination; Erythropoietin; Hematinics; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Ribavirin; Risk Factors; Serine Proteinase Inhibitors; Viral Nonstructural Proteins | 2013 |
[Boceprevir and telaprevir: clinical efficacy, safety and drug-drug interactions].
Topics: Antiviral Agents; Drug Interactions; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline | 2012 |
Role of interleukin-28B polymorphism as a predictor of sustained virological response in patients with chronic hepatitis C treated with triple therapy: a systematic review and meta-analysis.
Topics: Antiviral Agents; Drug Therapy, Combination; Gene Frequency; Genotype; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Interleukins; Linear Models; Odds Ratio; Oligopeptides; Pharmacogenetics; Phenotype; Polyethylene Glycols; Polymorphism, Single Nucleotide; Proline; Recombinant Proteins; Ribavirin; Treatment Outcome | 2013 |
HCV RNA viral load assessments in the era of direct-acting antivirals.
Topics: Antiviral Agents; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Protease Inhibitors; Real-Time Polymerase Chain Reaction; RNA, Viral; Viral Load | 2013 |
Hepatitis C virus therapy update 2013.
Topics: Antiviral Agents; Drug Discovery; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2013 |
Emerging therapeutic targets for hepatitis C virus infection.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Discovery; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Proline; Ribavirin | 2013 |
[Progress in hepatitis C treatment].
Topics: Anemia; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Eruptions; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Liver Transplantation; Multicenter Studies as Topic; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pruritus; Randomized Controlled Trials as Topic; Recurrence; Ribavirin; RNA, Viral; Treatment Outcome; Viral Load; Viremia | 2013 |
Pretransplant and posttransplant treatment of hepatitis C virus infection with protease inhibitors.
Topics: Antiviral Agents; Hepacivirus; Hepatitis C; Humans; Liver Transplantation; Oligopeptides; Postoperative Care; Preoperative Care; Proline; Protease Inhibitors | 2013 |
Psychiatric treatment considerations with direct acting antivirals in hepatitis C.
Topics: Antiviral Agents; Contraindications; Drug Interactions; Hepatitis C; Humans; Medication Adherence; Mental Disorders; Oligopeptides; Proline; Psychotropic Drugs | 2013 |
Evolution of cell culture systems for HCV.
Topics: Antiviral Agents; Cell Culture Techniques; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Replicon; Ribavirin; RNA, Viral; Virus Cultivation; Virus Replication | 2013 |
Protease inhibitors for hepatitis C: economic implications.
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Health Care Costs; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quality of Life; Recombinant Proteins; Ribavirin | 2013 |
Drug-drug interactions in the treatment of HCV among people who inject drugs.
Topics: Antiviral Agents; Drug Interactions; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Substance Abuse, Intravenous | 2013 |
[Treatment of chronic hepatitis C virus infection at the beginning of a new era].
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Polyethylene Glycols; Proline | 2013 |
Update on the use of direct-acting antiviral agents for the treatment of chronic hepatitis C virus infection.
Topics: Antiviral Agents; Drug Interactions; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Monitoring, Physiologic; Oligopeptides; Patient Selection; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic | 2013 |
Optimizing DAA management in daily practice.
Topics: Antiviral Agents; Checklist; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferons; Medication Adherence; Oligopeptides; Patient Education as Topic; Polyethylene Glycols; Proline; Ribavirin | 2013 |
Management of anaemia and other treatment complications.
Topics: Anemia; Antiviral Agents; Contraindications; Drug Eruptions; Drug Therapy, Combination; Dysgeusia; Hemorrhoids; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Patient Selection; Platelet Count; Polyethylene Glycols; Proline; Pruritus Ani; Ribavirin; Serum Albumin | 2013 |
The importance of drug-drug interactions in the DAA era.
Topics: Antiviral Agents; Contraindications; Cytochrome P-450 CYP3A; Databases, Pharmaceutical; Drug Interactions; Hepatitis C, Chronic; Humans; Internet; Oligopeptides; Proline | 2013 |
Treatment of chronic hepatitis C virus infection after liver transplantation.
Topics: Antiviral Agents; Drug Interactions; End Stage Liver Disease; Hepatitis C, Chronic; Humans; Interferons; Liver Cirrhosis; Liver Transplantation; Oligopeptides; Proline; Ribavirin; Secondary Prevention | 2013 |
Optimizing treatment in HIV/HCV coinfection.
Topics: Anti-Retroviral Agents; Antiviral Agents; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Interferons; Oligopeptides; Proline; Ribavirin | 2013 |
Safety of direct antiviral agents in real life.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C; Humans; Liver Cirrhosis; Oligopeptides; Proline; Protease Inhibitors | 2013 |
Triple therapy with first-generation protease inhibitors for patients with genotype 1 chronic hepatitis C: recommendations of the Italian association for the study of the liver (AISF).
Topics: Antiviral Agents; Drug Carriers; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin | 2014 |
Hepatitis C direct-acting antiviral agents: changing the paradigm of hepatitis C treatment in HIV-infected patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Coinfection; Hepatitis C; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferons; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2014 |
Evolution and emergence of a new era of antiviral treatment for chronic hepatitis C infection.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Oligopeptides; Proline | 2014 |
Treatment of patients with dual hepatitis C virus and hepatitis B virus infection: resolved and unresolved issues.
Topics: Antiviral Agents; Biomarkers; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis C; Humans; Interferon-alpha; Liver Neoplasms; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Virus Activation | 2014 |
Efficacy and safety of telaprevir and boceprevir in patients with hepatitis C genotype 1: a meta-analysis.
Topics: Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline | 2014 |
An overview of emerging therapies for the treatment of chronic hepatitis C.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Metabolic Networks and Pathways; Oligopeptides; Pharmacogenetics; Proline; Therapies, Investigational; Viral Hepatitis Vaccines; Virus Physiological Phenomena | 2014 |
Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting.
Topics: Administration, Oral; Anti-Bacterial Agents; Antiviral Agents; Calcineurin Inhibitors; Chemical and Drug Induced Liver Injury; Drug Interactions; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Liver Transplantation; Oligopeptides; Proline; Risk Factors; Tacrolimus; TOR Serine-Threonine Kinases | 2014 |
[Hepatitis C virus: 25 years-old, the end?].
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Proline; Protease Inhibitors; Ribavirin | 2013 |
How to optimize current therapy of HCV genotype 1 infection with boceprevir.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Risk Assessment; Treatment Outcome | 2014 |
Management of HCV patients with cirrhosis with direct acting antivirals.
Topics: Algorithms; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Liver Cirrhosis; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
Management of HCV transplant patients with triple therapy.
Topics: Antiviral Agents; Disease Management; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Liver Transplantation; Oligopeptides; Proline; Secondary Prevention; Treatment Outcome | 2014 |
Treating HCV in HIV 2013: on the cusp of change.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine | 2014 |
[The role of hepcidin and polymorphisms in the regulatory region of the IL-28B gene in HCV infections].
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Hepcidins; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polymorphism, Genetic; Prognosis; Proline; Protease Inhibitors; Regulatory Sequences, Nucleic Acid; Ribavirin; Treatment Outcome | 2013 |
[Hepatitis C update: what has changed? What can we expect in the near future?].
Topics: Antiviral Agents; Cross-Sectional Studies; Drug Approval; Drug Interactions; Drug Resistance, Viral; Drug Therapy, Combination; Drugs, Investigational; Germany; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Prognosis; Proline; Protease Inhibitors | 2013 |
Importance of HCV genotype 1 subtypes for drug resistance and response to therapy.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Species Specificity; Treatment Outcome | 2014 |
Hepatitis C treatment: an incipient therapeutic revolution.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Interferon-alpha; Molecular Targeted Therapy; Oligopeptides; Proline; Protease Inhibitors; Sofosbuvir; Uridine Monophosphate | 2014 |
Viral hepatitis C therapy: pharmacokinetic and pharmacodynamic considerations.
Topics: Antiviral Agents; Drug Interactions; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Proline; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Uridine Monophosphate | 2014 |
Peg-interferon plus ribavirin with or without boceprevir or telaprevir for HCV genotype 1: a meta-analysis on the role of response predictors.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome | 2014 |
Preparation of HCV infected patients to the triple therapy with first generation protease inhibitors.
Topics: Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Poland; Practice Guidelines as Topic; Proline; Protease Inhibitors; Ribavirin | 2013 |
Cost-effectiveness of protease inhibitor based regimens for chronic hepatitis C: a systematic review of published literature.
Topics: Cost-Benefit Analysis; Drug Labeling; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors; Quality-Adjusted Life Years | 2014 |
Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage?
Topics: Animals; Antiviral Agents; Arrhythmias, Cardiac; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Food-Drug Interactions; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Risk Assessment; Risk Factors; Serine Proteinase Inhibitors | 2014 |
Response-guided therapy in patients with genotype 1 hepatitis C virus: current status and future prospects.
Topics: Antiviral Agents; Clinical Trials as Topic; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Treatment Outcome; Viral Load; Virus Replication | 2014 |
Hepatitis C in HIV-infected patients: impact of direct-acting antivirals.
Topics: Antiviral Agents; Hepacivirus; Hepatitis C; HIV Infections; Humans; Oligopeptides; Proline | 2014 |
Emerging therapeutic options for the management of hepatitis C infection.
Topics: Animals; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Host-Pathogen Interactions; Humans; Molecular Targeted Therapy; Oligopeptides; Proline; Protease Inhibitors; RNA-Dependent RNA Polymerase; Treatment Outcome; Viral Nonstructural Proteins; Virus Replication | 2014 |
Treating hepatitis C in the elderly: the future is near?
Topics: Aged; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Medication Adherence; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2014 |
Decade in review-HCV: hepatitis C therapy-a fast and competitive race.
Topics: Antiviral Agents; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2014 |
Emerging treatments for chronic hepatitis C.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Proline | 2015 |
Hepatitis C management in post-transplant patients.
Topics: Antiviral Agents; Benzimidazoles; Carbamates; Drug Therapy, Combination; Fluorenes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Liver Transplantation; Oligopeptides; Polyethylene Glycols; Proline; Pyrrolidines; Recombinant Proteins; Recurrence; Ribavirin; Risk Factors; Simeprevir; Sofosbuvir; Sulfonamides; Treatment Outcome; Uridine Monophosphate; Valine; Viral Load | 2015 |
Which therapeutic option for hepatitis C virus genotype 1?
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Oligopeptides; Proline; Randomized Controlled Trials as Topic; Simeprevir; Sofosbuvir; Viral Load | 2015 |
Interferon-free antiviral combination therapies without nucleosidic polymerase inhibitors.
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Proline; Protease Inhibitors; Viral Nonstructural Proteins | 2014 |
[Hepatitis C: diagnosis, anti-viral therapy, after-care. Hungarian consensus guideline].
Topics: Antiviral Agents; Consensus; Disease Progression; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Hepatitis C; Humans; Hungary; Insurance Coverage; Insurance, Health; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Liver Failure; Liver Neoplasms; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Registries; Ribavirin; Treatment Outcome | 2015 |
Management of post transplant hepatitis C in the direct antiviral agents era.
Topics: Antiviral Agents; Carbamates; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Interferons; Liver Transplantation; Oligopeptides; Postoperative Complications; Proline; Protease Inhibitors; Pyrrolidines; Recurrence; Ribavirin; Simeprevir; Sofosbuvir; Valine; Viral Nonstructural Proteins | 2015 |
A meta-analysis platform methodology for determining the comparative effectiveness of antihepatitis C virus regimens.
Topics: Algorithms; Antiviral Agents; Bayes Theorem; Comparative Effectiveness Research; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Proline; Ribavirin; Treatment Outcome | 2015 |
Management of HCV in cirrhosis-a rapidly evolving landscape.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Proline | 2015 |
[Triple therapy in cirrhotic patients and those with advanced fibrosis: relevant aspects in clinical practice].
Topics: Anemia; Antiviral Agents; Clinical Trials as Topic; Cohort Studies; Comorbidity; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Hypertension, Portal; Interferon-alpha; Liver Cirrhosis; Medication Adherence; Metabolic Syndrome; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Risk Factors | 2014 |
A network meta-analysis to compare simeprevir with boceprevir and telaprevir in combination with peginterferon-α and ribavirin in patients infected with genotype 1 Hepatitis C virus.
Topics: Antiviral Agents; Clinical Trials as Topic; Databases, Bibliographic; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Immunologic Factors; Interferon-alpha; Oligopeptides; Proline; Protease Inhibitors; Ribavirin; Simeprevir; Viral Load | 2015 |
[Significance of hepatitis C virus baseline polymorphism during the antiviral therapy].
Topics: Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Interferons; Lactams, Macrocyclic; Macrocyclic Compounds; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Proline; Protease Inhibitors; Ribavirin; Simeprevir; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Virus Replication | 2015 |
Hepatitis C treatment from "response-guided" to "resource-guided" therapy in the transition era from interferon-containing to interferon-free regimens.
Topics: Antiviral Agents; Carbamates; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis C; Humans; Imidazoles; Interferons; Isoquinolines; Oligopeptides; Proline; Pyrrolidines; Ribavirin; Sofosbuvir; Sulfonamides; Time Factors; Valine; Viral Load | 2017 |
Micro-costing analysis of guideline-based treatment by direct-acting agents: the real-life case of hepatitis C management in Brazil.
Topics: Antiviral Agents; Brazil; Carbamates; Costs and Cost Analysis; Drug Costs; Genotype; Hepatitis C, Chronic; Humans; Imidazoles; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Proline; Pyrrolidines; Ribavirin; Simeprevir; Sofosbuvir; Valine | 2017 |
28 trial(s) available for proline and telaprevir
Article | Year |
---|---|
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients.
Topics: Antiviral Agents; Double-Blind Method; Drug Resistance, Viral; Genotype; Hepatitis C; Humans; Models, Theoretical; Mutation; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Viral Nonstructural Proteins | 2009 |
Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir.
Topics: Antiviral Agents; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C; Humans; Longitudinal Studies; Mutation, Missense; Oligopeptides; Proline; RNA, Viral; Sequence Analysis, DNA; Viral Nonstructural Proteins | 2011 |
Safe coadministration of raltegravir-based HAART in HIV-infected patients with HCV-cirrhosis receiving triple therapy with telaprevir or boceprevir.
Topics: Antiretroviral Therapy, Highly Active; Antiviral Agents; Coinfection; Drug Therapy, Combination; Female; Hepatitis C; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Pyrrolidinones; Raltegravir Potassium; Recombinant Proteins; Ribavirin | 2012 |
Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting.
Topics: Antiviral Agents; Drug Therapy, Combination; Eligibility Determination; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Platelet Count; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Risk Assessment; Treatment Outcome | 2013 |
Antiviral activity of boceprevir monotherapy in treatment-naive subjects with chronic hepatitis C genotype 2/3.
Topics: Adult; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Kinetics; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Replicon; RNA, Viral; Viral Load; Viral Nonstructural Proteins | 2013 |
Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24.
Topics: Aged; Antiviral Agents; Cohort Studies; Cryoglobulinemia; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Treatment Outcome; Vasculitis | 2014 |
Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890.
Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Female; France; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Ribavirin; Serine Proteinase Inhibitors; Treatment Outcome; Viral Load | 2013 |
Multicenter experience using telaprevir or boceprevir with peginterferon and ribavirin to treat hepatitis C genotype 1 after liver transplantation.
Topics: Aged; Antiviral Agents; Biopsy; Drug Therapy, Combination; Female; Genotype; Hepatitis C; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Interferon-alpha; Liver Failure; Liver Transplantation; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome | 2013 |
Renal impairment is frequent in chronic hepatitis C patients under triple therapy with telaprevir or boceprevir.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis C, Chronic; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Renal Insufficiency | 2014 |
The effects of boceprevir and telaprevir on the pharmacokinetics of maraviroc: an open-label, fixed-sequence study in healthy volunteers.
Topics: Adolescent; Adult; Antiviral Agents; Cyclohexanes; Healthy Volunteers; Humans; Male; Maraviroc; Middle Aged; Oligopeptides; Proline; Triazoles; Young Adult | 2014 |
Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir.
Topics: Adult; Aged; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Healthy Volunteers; Hepacivirus; Heterocyclic Compounds, 3-Ring; HIV; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oligopeptides; Oxazines; Piperazines; Proline; Pyridones; Young Adult | 2014 |
High post-transplant virological response in hepatitis C virus infected patients treated with pretransplant protease inhibitor-based triple therapy.
Topics: Drug Therapy, Combination; Hepatitis C; Humans; Interferon-alpha; Liver Transplantation; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA, Viral; Statistics, Nonparametric; Viral Load | 2015 |
HCV RNA assay sensitivity impacts the management of patients treated with direct-acting antivirals.
Topics: 2-Naphthylamine; Antiviral Agents; Biological Assay; Cyclopropanes; Drug Monitoring; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Lactams, Macrocyclic; Macrocyclic Compounds; Oligopeptides; Polyethylene Glycols; Proline; Reagent Kits, Diagnostic; Recombinant Proteins; Ribavirin; RNA, Viral; Sensitivity and Specificity; Sulfonamides; Treatment Outcome; Uracil; Viral Load | 2015 |
Using pharmacokinetic and viral kinetic modeling to estimate the antiviral effectiveness of telaprevir, boceprevir, and pegylated interferon during triple therapy in treatment-experienced hepatitis C virus-infected cirrhotic patients.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Kinetics; Male; Middle Aged; Models, Biological; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Treatment Outcome | 2014 |
eGFR decrease during antiviral C therapy with first generation protease inhibitors: a clinical significance?
Topics: Age Factors; Antiviral Agents; ErbB Receptors; Hepatitis C; Humans; Interferon-alpha; Kidney; Linear Models; Male; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Retrospective Studies; Ribavirin; Sex Factors | 2015 |
Lack of clinically significant pharmacokinetic interaction between the thrombopoietin receptor agonist eltrombopag and hepatitis C virus protease inhibitors boceprevir and telaprevir.
Topics: Adult; Area Under Curve; Benzoates; Calcium; Cross-Over Studies; Diet; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C, Chronic; Humans; Hydrazines; Male; Middle Aged; Oligopeptides; Proline; Purpura, Thrombocytopenic; Pyrazoles; Receptors, Thrombopoietin; Serine Proteinase Inhibitors; Young Adult | 2014 |
Safety profile of boceprevir and telaprevir in chronic hepatitis C: real world experience from HCV-TARGET.
Topics: Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Retrospective Studies; Treatment Outcome; Viral Load; Young Adult | 2015 |
Plasma apolipoprotein H limits HCV replication and associates with response to NS3 protease inhibitors-based therapy.
Topics: Aged; Antiviral Agents; Area Under Curve; beta 2-Glycoprotein I; Biomarkers; Drug Therapy, Combination; Female; France; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Molecular Targeted Therapy; Oligopeptides; Polyethylene Glycols; Predictive Value of Tests; Proline; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA, Viral; ROC Curve; Time Factors; Treatment Outcome; Viral Load; Viral Nonstructural Proteins; Virus Replication | 2015 |
Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir.
Topics: Adolescent; Adult; Age Factors; Aged; Algorithms; Antiviral Agents; Biomarkers; Comorbidity; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Longitudinal Studies; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Young Adult | 2015 |
Real-life experience with first generation HCV protease inhibitor therapy in Germany: The prospective, non-interventional PAN cohort.
Topics: Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Evidence-Based Medicine; Female; Germany; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Male; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Ribavirin; Treatment Outcome | 2015 |
Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies.
Topics: Adult; Antibodies, Viral; Antimetabolites; Antiviral Agents; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome | 2016 |
Adherence to ribavirin in chronic hepatitis C patients on antiviral treatment: Results from a randomized controlled trial using real-time medication monitoring.
Topics: Antiviral Agents; Drug Monitoring; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Medication Adherence; Middle Aged; Oligopeptides; Proline; Ribavirin | 2016 |
Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Leukocyte Elastase; Male; Middle Aged; Neutrophils; Oligopeptides; Proline; Prospective Studies; Protease Inhibitors; Retrospective Studies; Ribavirin; Treatment Outcome | 2016 |
Effects of Smoking on Pegylated Interferon alpha 2a and First Generation Protease Inhibitor-based Antiviral Therapy in Naïve Patients Infected with Hepatitis C Virus Genotype 1.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Germany; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Risk Factors; Smoking; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2016 |
Treatment Selection Choices Should Not Be Based on Benefits or Costs Alone: A Head-to-Head Randomized Controlled Trial of Antiviral Drugs for Hepatitis C.
Topics: Anemia; Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Drug Tolerance; Female; Hepatitis C; Hospitalization; Humans; Interferon-alpha; Male; Middle Aged; Mood Disorders; Oligopeptides; Proline; Ribavirin; Severity of Illness Index; Treatment Outcome | 2016 |
Health-Related Quality of Life in Chronic HCV-Infected Patients Switching to Pegylated-Interferon-Free Regimens (ANRS CO20 CUPIC Cohort Study and SIRIUS Trial).
Topics: Age Factors; Aged; Antiviral Agents; Benzimidazoles; Cohort Studies; Comorbidity; Double-Blind Method; Female; Fluorenes; Health Status; Hepatitis C, Chronic; Humans; Male; Mental Health; Middle Aged; Oligopeptides; Patient Reported Outcome Measures; Polyethylene Glycols; Proline; Quality of Life; Severity of Illness Index; Sex Factors; Sofosbuvir; Sustained Virologic Response; Uridine Monophosphate | 2017 |
Effectiveness and safety of first-generation protease inhibitors in real-world patients with hepatitis C virus genotype 1 infection in Brazil: a multicenter study.
Topics: Aged; Antiviral Agents; Brazil; Cross-Sectional Studies; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; RNA, Viral; Treatment Outcome | 2017 |
Hepatitis C in Brazil: lessons learned with boceprevir and telaprevir.
Topics: Antiviral Agents; Clinical Protocols; Decision Making; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Retrospective Studies; Ribavirin | 2018 |
223 other study(ies) available for proline and telaprevir
Article | Year |
---|---|
Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavir.
Topics: Animals; Antiviral Agents; Hepacivirus; Humans; Male; Microsomes, Liver; Models, Animal; Oligopeptides; Plasma; Proline; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Ritonavir | 2007 |
Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient.
Topics: Adult; Amino Acid Sequence; Base Sequence; Carbamates; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Macrocyclic Compounds; Male; Molecular Sequence Data; Oligopeptides; Point Mutation; Proline; Quinolines; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins | 2008 |
Characterization of resistance mutations against HCV ketoamide protease inhibitors.
Topics: Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Models, Molecular; Molecular Structure; Mutation, Missense; Oligopeptides; Proline; Protease Inhibitors; Viral Nonstructural Proteins; Viral Proteins; Virus Replication | 2008 |
[The 43rd Annual Meeting of the European Association for the Study of the Liver (EASL), Milan, Italy, April 23-27, 2008].
Topics: Antineoplastic Agents; Antiviral Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Clinical Trials as Topic; Delayed-Action Preparations; Europe; Hepatitis B; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Liver Diseases; Liver Neoplasms; Niacinamide; Oligopeptides; Patient Compliance; Phenylurea Compounds; Polyethylene Glycols; Proline; Pyridines; Recombinant Proteins; Ribavirin; Societies, Medical; Sorafenib | 2008 |
Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates.
Topics: Amino Acid Sequence; Antiviral Agents; Carbamates; Carrier Proteins; Drug Resistance, Viral; Global Health; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Macrocyclic Compounds; Microbial Sensitivity Tests; Molecular Sequence Data; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Sequence Alignment; Thiazoles; Viral Nonstructural Proteins; Viral Proteins | 2008 |
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients.
Topics: Antiviral Agents; Carbamates; Cohort Studies; Drug Resistance, Viral; Female; Genetic Testing; Hepacivirus; Hepatitis C; Humans; Macrocyclic Compounds; Male; Mutation; Oligopeptides; Phenylthiourea; Phylogeny; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load; Viral Nonstructural Proteins | 2008 |
Treatment of chronic hepatitis C: anticipated impact of resistance in patients treated with protease inhibitors.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Mutation; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Ribavirin; Viral Nonstructural Proteins; Virus Replication | 2009 |
Identification of HCV protease inhibitor resistance mutations by selection pressure-based method.
Topics: Antiviral Agents; DNA Mutational Analysis; Drug Resistance, Viral; Mutation; Oligopeptides; Proline; Serine Endopeptidases; Serine Proteinase Inhibitors; Viral Nonstructural Proteins | 2009 |
HCV-NS3 inhibitors: determination of their kinetic parameters and mechanism.
Topics: Amino Acid Substitution; Antiviral Agents; Carbamates; Drug Resistance, Viral; Genotype; Half-Life; Hepacivirus; Humans; Kinetics; Macrocyclic Compounds; Models, Biological; Mutation; Oligopeptides; Proline; Quinolines; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiazoles; Viral Nonstructural Proteins | 2009 |
Hepatitis C drug development at a crossroads.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Treatment Outcome | 2009 |
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS.
Topics: Antiviral Agents; Chromatography, Liquid; Hepacivirus; Humans; Oligopeptides; Peptide Hydrolases; Proline; Protease Inhibitors; Reference Standards; Tandem Mass Spectrometry | 2009 |
New directly acting antivirals for hepatitis C: potential for interaction with antiretrovirals.
Topics: Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Hepatitis C; HIV Infections; Humans; Oligopeptides; Proline | 2010 |
Estimation of inhibitory quotient using a comparative equilibrium dialysis assay for prediction of viral response to hepatitis C virus inhibitors.
Topics: Antiviral Agents; Blood Proteins; Carbamates; Cell Line; Comparative Effectiveness Research; Dialysis; Hepacivirus; Hepatitis C; Humans; Inhibitory Concentration 50; Macrocyclic Compounds; Membranes, Artificial; Oligopeptides; Phenylthiourea; Plasma; Proline; Protease Inhibitors; Protein Binding; Quinolines; RNA, Viral; Thiazoles; Viral Load | 2011 |
Excitement grows for potential revolution in hepatitis C virus treatment.
Topics: Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Oligopeptides; Proline; Protease Inhibitors | 2010 |
STAT-C: a full revolution or just a step forward?
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Virus Replication | 2010 |
On the cusp of change: new therapeutic modalities for HCV.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Costs; Drug Therapy, Combination; Drugs, Investigational; Evidence-Based Medicine; Hepatitis C; Humans; Oligopeptides; Patient Selection; Proline; Treatment Outcome; Viral Load | 2010 |
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication | 2010 |
Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors.
Topics: Antiviral Agents; Cell Line, Tumor; Cyclopropanes; Hepacivirus; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Molecular Structure; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Sulfonamides | 2010 |
Big changes are coming in hepatitis C.
Topics: Administration, Oral; Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Hepatitis C; Humans; Interferons; Oligopeptides; Proline; Protease Inhibitors; Ribavirin | 2011 |
The role of triple therapy in HCV genotype 1-experienced patients.
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2011 |
The results of Phase III clinical trials with telaprevir and boceprevir presented at the Liver Meeting 2010: a new standard of care for hepatitis C virus genotype 1 infection, but with issues still pending.
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Evidence-Based Medicine; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Patient Selection; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Treatment Outcome; Viral Load | 2011 |
Drugs in development for viral hepatitis: care and caution.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Hepatitis, Viral, Human; Humans; Oligopeptides; Proline | 2011 |
Infectious diseases. First specific drugs raise hopes for hepatitis C.
Topics: Antiviral Agents; Clinical Trials as Topic; Developing Countries; Drug Approval; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors; Viral Nonstructural Proteins | 2011 |
Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191).
Topics: Amino Acid Substitution; Cell Line, Tumor; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepacivirus; Humans; Inhibitory Concentration 50; Isoindoles; Lactams; Lactams, Macrocyclic; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Viral Nonstructural Proteins; Virus Replication | 2011 |
Distributive justice and the arrival of direct-acting antivirals: who should be first in line?
Topics: Algorithms; Antiviral Agents; Health Care Rationing; Hepatitis C; Humans; Oligopeptides; Proline; Resource Allocation; United States; United States Food and Drug Administration | 2011 |
Introduction: a smouldering public-health crisis.
Topics: Adolescent; France; Global Health; Hepacivirus; Hepatitis C; HIV Infections; Humans; Oligopeptides; Proline; Public Health; Viral Hepatitis Vaccines; Young Adult | 2011 |
Therapeutics: new drugs hit the target.
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Oligopeptides; Proline; Ribavirin; Simeprevir; Sulfonamides | 2011 |
Perspective: miles to go before we sleep.
Topics: Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Time Factors | 2011 |
Two drugs approved for chronic hepatitis C infection.
Topics: Antiviral Agents; Drugs, Investigational; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2011 |
Viral hepatitis: progress and promise.
Topics: Antiviral Agents; Hepatitis B; Hepatitis C; Humans; Oligopeptides; Patient Compliance; Pharmacogenetics; Proline; Treatment Outcome | 2011 |
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Molecular Sequence Data; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins | 2011 |
Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents--a potentially lethal cocktail.
Topics: Antiviral Agents; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Hepatitis C; Humans; Immunosuppressive Agents; Liver Transplantation; Oligopeptides; Proline; Tacrolimus | 2011 |
The critical role of medication adherence in the success of boceprevir and telaprevir in clinical practice.
Topics: Antiviral Agents; Hepatitis C, Chronic; Humans; Medication Adherence; Oligopeptides; Proline | 2012 |
New Merck and Vertex drugs raise standard of care in hepatitis C.
Topics: Antiviral Agents; Drug Industry; Hepatitis C; Humans; Oligopeptides; Proline; Quality of Health Care; United States | 2011 |
Boceprevir for chronic HCV genotype 1 infection.
Topics: Anemia; Antiviral Agents; Drug Therapy, Combination; Erythropoietin; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Viral Load | 2011 |
Telaprevir (Incivek) and boceprevir (Victrelis) for chronic hepatitis C.
Topics: Antiviral Agents; Drug Therapy, Combination; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2011 |
HCV protease inhibitors bring new options for patients.
Topics: Adult; Antiviral Agents; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors; Virus Replication | 2011 |
Impact of ribavirin on HCV replicon RNA decline during treatment with interferon-α and the protease inhibitors boceprevir or telaprevir.
Topics: Antiviral Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Models, Theoretical; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Replicon; Ribavirin; RNA, Viral; Time Factors; Viral Load | 2011 |
Going viral.
Topics: Anti-HIV Agents; Drug Approval; Hepatitis C; Humans; Oligopeptides; Proline | 2011 |
[A new era in therapy of hepatitis C: "the therapy can now be individualized" (interview by Dr. med. Dirk Einecke)].
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Precision Medicine; Proline; Protease Inhibitors | 2011 |
An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases.
Topics: Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Oligopeptides; Prognosis; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Assessment; Societies, Medical; Treatment Outcome; United States | 2011 |
Will direct-acting antivirals make a difference in HIV-HCV coinfected patients?
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Coinfection; Drug Interactions; Hepacivirus; Hepatitis C; HIV; HIV Infections; Humans; Interferons; Oligopeptides; Proline; Ribavirin; Serine Proteases; Serine Proteinase Inhibitors; Viral Proteins | 2011 |
[New treatments for hepatitis C, which targets, what timeline?].
Topics: Antiviral Agents; Hepatitis C; Humans; Oligopeptides; Proline | 2011 |
[New triple therapy in chronic hepatitis C. Increased patient chances].
Topics: Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Proline; Protease Inhibitors; Ribavirin; RNA, Viral | 2011 |
The expanding role of the pharmacist in the management of hepatitis C infection.
Topics: Female; Hepatitis C, Chronic; Humans; Male; Oligopeptides; Proline; Protease Inhibitors | 2011 |
Clinical relevance of detectable but not quantifiable hepatitis C virus RNA during boceprevir or telaprevir treatment.
Topics: Antiviral Agents; Biomarkers; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Decision Making; Follow-Up Studies; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Predictive Value of Tests; Proline; Retrospective Studies; RNA, Viral; Treatment Outcome | 2012 |
Specific detection of naturally occurring hepatitis C virus mutants with resistance to telaprevir and boceprevir (protease inhibitors) among treatment-naïve infected individuals.
Topics: Adult; Antiviral Agents; Biota; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Mutation; Oligopeptides; Polymerase Chain Reaction; Proline; Virology | 2012 |
Protease inhibitors in hepatitis C: from chronic disease to cure.
Topics: Antiviral Agents; Genotype; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2011 |
New HCV drugs trigger race for more tolerable therapies.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Industry; Drug Resistance, Multiple, Viral; Drugs, Investigational; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Proline | 2011 |
Peptidomimetic escape mechanisms arise via genetic diversity in the ligand-binding site of the hepatitis C virus NS3/4A serine protease.
Topics: Antiviral Agents; Binding Sites; Carrier Proteins; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Resistance, Viral; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Models, Molecular; Molecular Structure; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Protein Conformation; Time Factors; Transfection; Viral Nonstructural Proteins; Virus Replication | 2012 |
Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons.
Topics: Antiviral Agents; Genotype; Guidelines as Topic; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Oligopeptides; Proline; Protease Inhibitors; United States | 2012 |
A major advance in treating hepatitis C.
Topics: Antiviral Agents; Drug Administration Schedule; Drug Approval; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; United States; United States Food and Drug Administration | 2011 |
New developments in HCV therapy.
Topics: Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors; Treatment Outcome; Viral Nonstructural Proteins | 2012 |
Direct-acting antiviral (DAA) actions in treatment-naïve patients.
Topics: Antiviral Agents; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2011 |
New hepatitis C regimen stimulates changes in therapy management.
Topics: Anemia; Antiviral Agents; Disease Management; Drug Interactions; Hematinics; Hepatitis C; Humans; Oligopeptides; Proline; Protease Inhibitors; Standard of Care | 2011 |
UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients.
Topics: Algorithms; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Patient Selection; Polyethylene Glycols; Proline; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; United Kingdom; Viral Load | 2012 |
[Use of boceprevir and telaprevir in patients with hepatitis C virus infection (practical considerations)].
Topics: Antiviral Agents; Drug Eruptions; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2012 |
[Hungarian consensus guideline for the diagnosis and treatment of B, C, and D viral hepatitis].
Topics: Adenine; Antiviral Agents; Comorbidity; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Guanine; Hepacivirus; Hepatitis B; Hepatitis C; Hepatitis D; Humans; Hungary; Interferon-alpha; Interferons; Lamivudine; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome | 2012 |
[Current indications for triple therapy in hepatitis C virus infection].
Topics: Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2012 |
Triple therapy for hepatitis C.
Topics: Antiviral Agents; Hepatitis C, Chronic; Humans; Oligopeptides; Proline | 2012 |
[New times for the treatment of chronic hepatitis C].
Topics: Antiviral Agents; Drugs, Investigational; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors; Virus Replication | 2012 |
Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C.
Topics: Cost-Benefit Analysis; Genotype; Hepatitis C; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline | 2012 |
Targeted therapies for hepatitis C reach the clinic.
Topics: Antiviral Agents; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline | 2012 |
Update on the management and treatment of hepatitis C virus infection: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office.
Topics: Antiviral Agents; Genotype; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Polymorphism, Single Nucleotide; Proline; Recombinant Proteins; Ribavirin; Risk Factors | 2012 |
Genetic factors and hepatitis C virus infection.
Topics: Antiviral Agents; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Polymorphism, Single Nucleotide; Predictive Value of Tests; Proline; Recombinant Proteins; Ribavirin; Risk Factors; Treatment Outcome | 2012 |
[Position paper of the Catalan Society of Gastroenterology: treatment of Genotype 1 Chronic Hepatitis C Virus with Triple Therapy].
Topics: Antiviral Agents; Biopsy; Contraindications; Diagnostic Imaging; Drug Therapy, Combination; Genotype; Health Services Accessibility; Hepacivirus; Hepatitis C, Chronic; Humans; Informed Consent; Interferon Type I; Interferons; Interleukins; Liver Cirrhosis; Oligopeptides; Patient Care Team; Polyethylene Glycols; Proline; Protease Inhibitors; Recurrence; Ribavirin; Viral Load | 2012 |
New genetic discoveries and treatment for hepatitis C.
Topics: Antiviral Agents; DNA, Viral; Genotype; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Pharmacogenetics; Polyethylene Glycols; Polymorphism, Single Nucleotide; Precision Medicine; Proline; Recombinant Proteins; Ribavirin | 2012 |
Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor.
Topics: Cell Proliferation; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Models, Genetic; Mutation; Numerical Analysis, Computer-Assisted; Oligopeptides; Proline; Protease Inhibitors | 2012 |
Recent successes and noteworthy future prospects in the treatment of chronic hepatitis C.
Topics: Antiviral Agents; Clinical Trials as Topic; Cyclophilins; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; MicroRNAs; Oligopeptides; Proline; Protease Inhibitors; Treatment Outcome; Viral Nonstructural Proteins; Virus Replication | 2012 |
Effect of discounting on estimation of benefits determined by hepatitis C treatment.
Topics: Antiviral Agents; Computer Simulation; Cost-Benefit Analysis; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Markov Chains; Oligopeptides; Proline; Quality-Adjusted Life Years; Ribavirin | 2012 |
Telaprevir and boceprevir in African Americans with genotype 1 chronic hepatitis C: implications for patients and providers.
Topics: Antiviral Agents; Black or African American; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Proline; Research Subjects; Ribavirin; Serine Proteinase Inhibitors; Time Factors; Treatment Failure | 2012 |
Update of the Belgian Association for the Study of the Liver guidelines for the treatment of chronic hepatitis C genotype 1 with protease inhibitors.
Topics: Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2012 |
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Topics: Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins | 2012 |
[Treatment of chronic hepatitis C in HIV coinfection].
Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Comorbidity; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Liver Cirrhosis; Oligopeptides; Proline; Serine Proteinase Inhibitors | 2012 |
New protease inhibitors and direct-acting antivirals for hepatitis C: interferon's long goodbye.
Topics: Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Treatment Failure | 2012 |
[Treatment of chronic hepatitis viral C: new associations].
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2013 |
Triple therapy with first generation HCV protease inhibitors: lead-in or no lead-in phase?
Topics: Antiviral Agents; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Treatment Outcome | 2013 |
Approach to the treatment-experienced patient with hepatitis C virus genotype 1 infection.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Recurrence; Ribavirin; RNA, Viral; Viral Load | 2012 |
Treatment of hepatitis C in patients infected with human immunodeficiency virus in the direct-acting antiviral era.
Topics: Antiviral Agents; Coinfection; Drug Resistance, Viral; Hepacivirus; Hepatitis C; HIV Infections; Humans; Oligopeptides; Proline | 2012 |
The changing face of hepatitis C in the new era of direct-acting antivirals.
Topics: Antiviral Agents; Asymptomatic Diseases; Carrier State; Health Services Accessibility; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Treatment Outcome | 2013 |
Telaprevir to boceprevir switch highlights lack of cross-reactivity.
Topics: Antiviral Agents; Cross Reactions; Drug Substitution; Eosinophilia; Exanthema; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; RNA, Viral; Viral Load | 2013 |
[Prevalence of potential interactions between antiretroviral therapy and boceprevir or telaprevir in human immunodeficiency virus-hepatitis C virus coinfected patients].
Topics: Adult; Aged; Anti-Retroviral Agents; Coinfection; Drug Interactions; Female; Hepatitis C, Chronic; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Proline; Retrospective Studies | 2013 |
Hepatitis C in 2012.
Topics: Antiviral Agents; Drug Therapy, Combination; Gastroenterology; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Proline; Ribavirin | 2012 |
Challenges in the treatment of chronic hepatitis C in the HIV/HCV-coinfected patient.
Topics: Anti-HIV Agents; Antiviral Agents; Clinical Trials, Phase II as Topic; Coinfection; Drug Interactions; Hepatitis C, Chronic; HIV Infections; Humans; Liver Transplantation; Oligopeptides; Proline; Treatment Outcome | 2012 |
Triple therapy with boceprevir or telaprevir for prior HCV non-responders.
Topics: Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Proline; Protease Inhibitors; Recombinant Proteins; Recurrence; Retreatment; Ribavirin | 2012 |
[Israeli guidelines for the treatment of chronic hepatitis C infection--2012 Israeli Association for the Study of the Liver].
Topics: Antiviral Agents; Drug Approval; Drug Design; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-Stimulated Gene Factor 3, gamma Subunit; Oligopeptides; Proline | 2012 |
Is the HCV pipeline heading in the right direction?
Topics: Antiviral Agents; Coinfection; Drug Discovery; Health Services Accessibility; Hepatitis C; HIV Infections; Humans; Liver Cirrhosis; Liver Transplantation; Off-Label Use; Oligopeptides; Proline; Treatment Outcome | 2013 |
Closing in on the target: sustained virologic response in hepatitis C virus genotype 1 infection response-guided therapy.
Topics: Antiviral Agents; Clinical Trials as Topic; Hepacivirus; Hepatitis C, Chronic; Humans; Limit of Detection; Oligopeptides; Proline; Retrospective Studies; RNA, Viral; Treatment Outcome; Viral Load | 2013 |
Current management of hepatitis C virus infection in patients with HIV co-infection.
Topics: Antiviral Agents; Clinical Trials as Topic; Coinfection; Drug Therapy, Combination; Hepatitis C; HIV Infections; Humans; Male; Oligopeptides; Proline; Treatment Outcome | 2013 |
The FDA, bridging data, and hepatitis C.
Topics: Antiviral Agents; Drug Approval; Drug Monitoring; Hepatitis C, Chronic; Humans; Oligopeptides; Proline | 2013 |
Earlier sustained virologic response end points for regulatory approval and dose selection of hepatitis C therapies.
Topics: Adolescent; Adult; Albumins; Antiviral Agents; Child; Child, Preschool; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Approval; Endpoint Determination; Female; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load | 2013 |
A UPLC-MS/MS method for the simultaneous plasma quantification of all isomeric forms of the new anti-HCV protease inhibitors boceprevir and telaprevir.
Topics: Chromatography, Liquid; Hepatitis C; Humans; Isomerism; Limit of Detection; Oligopeptides; Proline; Protease Inhibitors; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2013 |
Early virologic responses and hematologic safety of direct-acting antiviral therapies in veterans with chronic hepatitis C.
Topics: Aged; Anemia; Antiviral Agents; Drug-Related Side Effects and Adverse Reactions; Female; Hepatitis C, Chronic; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Ribavirin; Treatment Outcome; Veterans; Viral Load | 2013 |
What about us? Recent advances in the treatment of chronic hepatitis C threaten to leave some parts of the world behind.
Topics: Antiviral Agents; Developing Countries; Genotype; Health Services Accessibility; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Pakistan; Proline | 2013 |
A small percentage of patients with hepatitis C receive triple therapy with boceprevir or telaprevir.
Topics: Aged; Antiviral Agents; Cross-Sectional Studies; Drug Therapy, Combination; Drug Utilization; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Retrospective Studies; Ribavirin; United States | 2013 |
Multiplex liquid chromatography-tandem mass spectrometry assay for simultaneous therapeutic drug monitoring of ribavirin, boceprevir, and telaprevir.
Topics: Antiviral Agents; Chromatography, Liquid; Drug Monitoring; Hepacivirus; Hepatitis; Humans; Liver Cirrhosis; Oligopeptides; Proline; Ribavirin; Tandem Mass Spectrometry | 2013 |
Triple combination therapy for hepatitis C with telaprevir exhibits greater early antiviral activity than with boceprevir.
Topics: Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Treatment Outcome; Viral Load; Young Adult | 2013 |
Telaprevir and boceprevir: a potential role for therapeutic drug monitoring.
Topics: Antiviral Agents; Area Under Curve; Drug Monitoring; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Protease Inhibitors | 2013 |
Cost effectiveness of direct-acting antiviral therapy for treatment-naive patients with chronic HCV genotype 1 infection in the veterans health administration.
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Life Expectancy; Male; Middle Aged; Oligopeptides; Proline; Quality of Life; Ribavirin; Survival Analysis; Treatment Outcome; United States; United States Department of Veterans Affairs; Veterans Health | 2013 |
Cost-effectiveness of boceprevir or telaprevir for previously treated patients with genotype 1 chronic hepatitis C.
Topics: Antiviral Agents; Cost-Benefit Analysis; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Italy; Male; Markov Chains; Middle Aged; Models, Economic; Oligopeptides; Proline; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Treatment Failure | 2013 |
Mixed genotype hepatitis C infections and implications for treatment.
Topics: Antiviral Agents; Drug Resistance, Viral; Genotype; Hepatitis C; Humans; Oligopeptides; Prevalence; Proline | 2014 |
Direct-acting antiviral-associated dermatitis during chronic hepatitis C virus treatment.
Topics: Antiviral Agents; Drug Eruptions; Drug Hypersensitivity Syndrome; Female; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Severity of Illness Index | 2013 |
Rapid progression of antiviral treatments of chronic hepatitis C virus infection.
Topics: Administration, Oral; Antiviral Agents; Drug Prescriptions; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Time Factors | 2013 |
Pretreatment resistance to hepatitis C virus protease inhibitors boceprevir/telaprevir in hepatitis C virus subgenotype 1a-infected patients from Manitoba.
Topics: Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Indians, North American; Male; Manitoba; Middle Aged; Mutation; Oligopeptides; Proline; Protease Inhibitors; Sequence Analysis, DNA; Viral Nonstructural Proteins; Young Adult | 2013 |
Polypharmacy and comorbidity are associated with a lower early virologic response in hepatitis C patients treated with first generation protease inhibitor triple therapy: a preliminary analysis.
Topics: Adult; Aged; Antiviral Agents; Drug Interactions; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Male; Middle Aged; Oligopeptides; Polypharmacy; Proline; Retrospective Studies; Ribavirin; Viral Load | 2013 |
[Therapy of hepatitis C: new inhibitors as hammers against HCV].
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Drugs, Investigational; Hepacivirus; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Oligopeptides; Proline; Protease Inhibitors | 2013 |
Cost-effectiveness analysis of triple therapy with protease inhibitors in treatment-naive hepatitis C patients.
Topics: Age Factors; Antiviral Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Disease Progression; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Interleukins; Markov Chains; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quality-Adjusted Life Years; Recombinant Proteins; Ribavirin; Spain | 2013 |
Cost-effectiveness of telaprevir in combination with pegylated interferon alpha and ribavirin in treatment-experienced chronic hepatitis C genotype 1 patients.
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Markov Chains; Oligopeptides; Polyethylene Glycols; Proline; Quality-Adjusted Life Years; Recombinant Proteins; Ribavirin | 2014 |
Treatment of hepatitis C monoinfection in adults--Dutch national guidelines.
Topics: Adult; Antiviral Agents; Drug Interactions; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Netherlands; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin | 2013 |
New triple therapy for chronic hepatitis C: real life clinical experience in a community setting.
Topics: Antiviral Agents; Community Health Services; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Retrospective Studies; Ribavirin; Viral Load | 2013 |
Defer or treat? Reasons for treatment decisions in patients with chronic hepatitis C genotype 1 in the early era of directly acting antiviral agents.
Topics: Adult; Aged; Antiviral Agents; Cohort Studies; Decision Making; Disease Progression; Drug Carriers; Drug Discovery; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Logistic Models; Male; Middle Aged; Multivariate Analysis; Oligopeptides; Patient Preference; Polyethylene Glycols; Proline; Prospective Studies; Ribavirin; Severity of Illness Index; Time Factors; Watchful Waiting | 2014 |
The clinical significance of drug-drug interactions in the era of direct-acting anti-viral agents against chronic hepatitis C.
Topics: Adult; Aged; Antiviral Agents; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors | 2013 |
Seizures in patients with chronic hepatitis C treated with NS3/4A protease inhibitors: does pharmacological interaction play a role?
Topics: Adult; Antiviral Agents; Carrier Proteins; Drug Interactions; Follow-Up Studies; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Seizures; Viral Nonstructural Proteins | 2013 |
Comparative effectiveness of the hepatitis C virus protease inhibitors boceprevir and telaprevir in a large U.S. cohort.
Topics: Antiviral Agents; Cohort Studies; Comparative Effectiveness Research; Female; Hepatitis C; Humans; Interferon-alpha; Male; Middle Aged; Neutropenia; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Thrombocytopenia; United States; Veterans | 2014 |
Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors.
Topics: Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Genotype; Hepacivirus; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Liver; Liver Neoplasms; Mutation; Oligopeptides; Proline; Protease Inhibitors; Pyrrolidines; Valine; Viral Nonstructural Proteins | 2014 |
The dilemma for patients with chronic hepatitis C: treat now or warehouse?
Topics: Antiviral Agents; Drug Carriers; Drug Discovery; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Time Factors; Watchful Waiting | 2014 |
EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
Topics: Antiviral Agents; Contraindications; Drug Monitoring; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Liver Cirrhosis; Oligopeptides; Proline; Ribavirin | 2014 |
Prevalence of hepatitis C virus mutants resistant to protease inhibitors among Polish HCV genotype 1-infected patients.
Topics: Antiviral Agents; Drug Resistance, Viral; Female; Genetics, Population; Genotype; Hepacivirus; Hepatitis C; Humans; Male; Mutation; Oligopeptides; Prevalence; Proline; Protease Inhibitors; Sequence Analysis | 2013 |
Similar effectiveness of boceprevir and telaprevir treatment regimens for hepatitis C virus infection on the basis of a nationwide study of veterans.
Topics: Adult; Aged; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Treatment Outcome; United States; Veterans | 2014 |
[Boceprevir and telaprevir utilization: evaluation for the treatment of chronic hepatitis C].
Topics: Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Guideline Adherence; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Treatment Outcome | 2014 |
[Boceprevir and telaprevir safety in routine clinical practice].
Topics: Adult; Aged; Anemia; Antiviral Agents; Female; Humans; Male; Middle Aged; Oligopeptides; Proline; Rectal Diseases; Retrospective Studies; Thrombocytopenia | 2014 |
Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors.
Topics: Antiviral Agents; Carbamates; Cloning, Molecular; Cyclopropanes; Drug Resistance, Viral; Escherichia coli; Gene Expression; Genetic Variation; Genotype; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Macrocyclic Compounds; Mutation; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Quinolines; Recombinant Proteins; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2014 |
Telaprevir or boceprevir based therapy for chronic hepatitis C infection: development of resistance-associated variants in treatment failure.
Topics: Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Mutation, Missense; Oligopeptides; Proline; Ribavirin; RNA, Viral; Treatment Failure; Viral Load; Viral Nonstructural Proteins | 2014 |
Hepatitis C virus treatment: the unyielding chasm between efficacy and effectiveness.
Topics: Antiviral Agents; Female; Hepatitis C, Chronic; Humans; Male; Oligopeptides; Proline | 2014 |
Boceprevir and telaprevir-based triple therapy for chronic hepatitis C: virological efficacy and impact on kidney function and model for end-stage liver disease score.
Topics: Adult; Aged; Antiviral Agents; Drug-Related Side Effects and Adverse Reactions; End Stage Liver Disease; Female; Genotype; Glomerular Filtration Rate; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Kidney; Kidney Function Tests; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Ribavirin; Severity of Illness Index; Treatment Outcome; Viral Load | 2014 |
A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants.
Topics: Antiviral Agents; Carbamates; Drug Resistance, Viral; Hepacivirus; Macrocyclic Compounds; Models, Statistical; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Protease Inhibitors; Quinolines; Replicon; RNA, Viral; Stochastic Processes; Thiazoles; Viral Nonstructural Proteins; Virus Replication | 2014 |
Should we await IFN-free regimens to treat HCV genotype 1 treatment-naive patients? A cost-effectiveness analysis (ANRS 95141).
Topics: Antiviral Agents; Cost-Benefit Analysis; Decision Support Techniques; Drug Therapy, Combination; France; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Liver Cirrhosis; Middle Aged; Models, Economic; Oligopeptides; Proline; Quality-Adjusted Life Years; Ribavirin; Treatment Outcome | 2014 |
Hepatitis C treatment & management.
Topics: Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Liver Transplantation; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Recurrence; Ribavirin; Sofosbuvir; Time Factors; Uridine Monophosphate | 2014 |
Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis.
Topics: Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies; Ribavirin; Severity of Illness Index | 2014 |
[Treatment of hepatitis C infection. A revolution should not hide another].
Topics: Antiviral Agents; Drug Therapy, Combination; France; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Oligopeptides; Proline; Protease Inhibitors; Ribavirin; Risk Reduction Behavior | 2014 |
Impact of provider type on hepatitis C outcomes with boceprevir-based and telaprevir-based regimens.
Topics: Antiviral Agents; Cohort Studies; Female; Genotype; Health Personnel; Hematologic Diseases; Hepacivirus; Hepatitis C; Humans; Male; Middle Aged; Oligopeptides; Proline; Retrospective Studies; Treatment Outcome; Veterans; Viral Load | 2015 |
The position of the Sociedad Española de Patología Digestiva on the current situation of hepatitis C management in Spain.
Topics: Antiviral Agents; Hepatitis C; Humans; Oligopeptides; Proline; Spain | 2014 |
Cost-effectiveness of sofosbuvir-based triple therapy for untreated patients with genotype 1 chronic hepatitis C.
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Quality-Adjusted Life Years; Sofosbuvir; Uridine Monophosphate | 2014 |
Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis.
Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Cohort Studies; Comorbidity; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Recombinant Proteins; Ribavirin; Treatment Failure; Treatment Outcome | 2014 |
Therapeutic potential of and treatment with boceprevir/telaprevir-based triple-therapy in HIV/chronic hepatitis C co-infected patients in a real-world setting.
Topics: Adult; Antiviral Agents; Austria; Coinfection; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Retrospective Studies; Ribavirin; RNA, Viral; Treatment Outcome; Young Adult | 2014 |
A US multicenter study of hepatitis C treatment of liver transplant recipients with protease-inhibitor triple therapy.
Topics: Adult; Aged; Cohort Studies; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Retrospective Studies; Ribavirin; RNA, Viral; Treatment Outcome; United States | 2014 |
Letter: Telaprevir triple therapy in chronic hepatitis C genotype 1 patients receiving haemodialysis.
Topics: Antiviral Agents; Female; Hepatitis C; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin | 2014 |
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents.
Topics: Antibodies, Neutralizing; Antiviral Agents; Carbamates; Cell Communication; Cells, Cultured; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Imidazoles; Oligopeptides; Proline; Pyrrolidines; Valine; Viral Load; Virus Internalization | 2014 |
A population approach to disease management: hepatitis C direct-acting antiviral use in a large health care system.
Topics: Anemia; Antiviral Agents; Biomarkers; Comparative Effectiveness Research; Delivery of Health Care; Drug Prescriptions; Drug Therapy, Combination; Education, Medical, Continuing; Education, Pharmacy, Continuing; Guideline Adherence; Hematinics; Hepacivirus; Hepatitis C; Humans; Medication Therapy Management; Oligopeptides; Pharmaceutical Services; Practice Guidelines as Topic; Practice Patterns, Physicians'; Proline; Registries; RNA, Viral; Time Factors; Treatment Outcome; United States; United States Department of Veterans Affairs; Viral Load | 2014 |
Activation of inflammasomes by agents causing idiosyncratic skin reactions: a possible biomarker.
Topics: Biomarkers; Cell Line; Dimethyl Fumarate; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Ethacrynic Acid; Fumarates; Humans; Inflammasomes; Molecular Structure; Oligopeptides; Proline; Skin; Structure-Activity Relationship | 2014 |
Safety and efficacy of protease inhibitor based combination therapy in a single-center "real-life" cohort of 110 patients with chronic hepatitis C genotype 1 infection.
Topics: Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Treatment Outcome; Viral Load | 2014 |
Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Line; Cyclopropanes; DNA Mutational Analysis; GB virus C; Host-Pathogen Interactions; Humans; Interferon Type I; Isoindoles; Lactams; Lactams, Macrocyclic; Mutant Proteins; Oligopeptides; Proline; Protease Inhibitors; RNA Helicases; Serine Endopeptidases; Sulfonamides; Viral Nonstructural Proteins | 2014 |
[Treatment of hepatitis C: current status and perspectives].
Topics: Antiviral Agents; Drug Therapy, Combination; Evidence-Based Medicine; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Oligopeptides; Practice Guidelines as Topic; Proline; Protease Inhibitors; Ribavirin; Treatment Outcome | 2014 |
Cutaneous side-effects of antihepatitis C treatment: the U.K. experience.
Topics: Antiviral Agents; Drug Eruptions; Female; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; United Kingdom | 2015 |
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.
Topics: Animals; Boronic Acids; Carbamates; Carboxylic Ester Hydrolases; Dipeptidyl-Peptidase IV Inhibitors; Drug Discovery; Enzyme Inhibitors; Female; Glucose Tolerance Test; Glutamates; High-Throughput Screening Assays; Humans; Lipopolysaccharides; Macaca fascicularis; Male; Mice, Inbred C57BL; Nitriles; Oligopeptides; Piperazines; Proline; Serine Proteases; Serine Proteinase Inhibitors | 2014 |
A case of successful treatment with telaprevir-based triple therapy for hepatitis C infection after treatment failure with vaniprevir-based triple therapy.
Topics: Aged; Antiviral Agents; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Oligopeptides; Proline; Sulfonamides; Treatment Failure | 2014 |
Management of treatment-naïve chronic hepatitis C genotype 1 patients: a cost-effectiveness analysis of treatment options.
Topics: Adult; Aged; Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Italy; Middle Aged; Oligopeptides; Proline; Prospective Studies | 2015 |
Hepatitis C virus NS3 protease genotyping and drug concentration determination during triple therapy with telaprevir or boceprevir for chronic infection with genotype 1 viruses, southeastern France.
Topics: Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; France; Genotype; Hepacivirus; Hepatitis C, Chronic; Hospitals, University; Humans; Interferon-alpha; Male; Middle Aged; Mutation, Missense; Oligopeptides; Plasma; Proline; Ribavirin; Treatment Failure; Viral Load; Viral Nonstructural Proteins; Young Adult | 2014 |
Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Drug Resistance, Viral; Evolution, Molecular; Genetic Variation; Hepacivirus; Hepatitis C, Chronic; High-Throughput Nucleotide Sequencing; Humans; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies; Sequence Analysis, RNA; Viral Nonstructural Proteins | 2014 |
Cost-effectiveness analysis of sofosbuvir plus peginterferon/ribavirin in the treatment of chronic hepatitis C virus genotype 1 infection.
Topics: Antiviral Agents; Cost-Benefit Analysis; Decision Support Techniques; Drug Therapy, Combination; Genotype; Health Care Costs; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferon-alpha; Liver Cirrhosis; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Uridine Monophosphate | 2014 |
Effectiveness of telaprevir and boceprevir triple therapy for patients with hepatitis C virus infection in a large integrated care setting.
Topics: Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Retrospective Studies; Ribavirin; RNA, Viral; Young Adult | 2014 |
Cost utility of telaprevir-PR (peginterferon-ribavirin) versus boceprevir-PR and versus PR alone in chronic hepatitis C in The Netherlands.
Topics: Adult; Antiviral Agents; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Markov Chains; Middle Aged; Netherlands; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Severity of Illness Index | 2014 |
[Incidence, management and costs of adverse effects in chronic hepatitis C patients on triple therapy with telaprevir or boceprevir: first 12 weeks of treatment].
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Hepatitis C, Chronic; Humans; Incidence; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Retrospective Studies; Ribavirin; Time Factors | 2015 |
Effectiveness research in the evolving HCV landscape.
Topics: Antiviral Agents; Female; Hepatitis C, Chronic; Humans; Male; Oligopeptides; Proline | 2014 |
Not so sweet: autoimmune diabetes mellitus on triple therapy for chronic hepatitis C infection.
Topics: Adult; Antiviral Agents; Autoimmune Diseases; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Polymorphism, Single Nucleotide; Proline; Protease Inhibitors; Ribavirin; Young Adult | 2015 |
"Fighting an uphill battle": experience with the HCV triple therapy: a qualitative thematic analysis.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors | 2014 |
Cost-effectiveness of IL28Β genotype-guided protease inhibitor triple therapy versus standard of care treatment in patients with hepatitis C genotypes 2 or 3 infection.
Topics: Adult; Aged; Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Standard of Care; Treatment Outcome | 2014 |
Individualized treatment of genotype 1 naïve patients: an Italian multicenter field practice experience.
Topics: Decision Making; Drug Therapy, Combination; Female; Genetic Association Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Italy; Male; Middle Aged; Oligopeptides; Precision Medicine; Proline; Treatment Outcome | 2014 |
Drug-drug interactions of telaprevir and boceprevir in HCV-monoinfected and HIV/HCV-coinfected patients can modify the adherence.
Topics: Adult; Aged; Antiviral Agents; Coinfection; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Logistic Models; Male; Middle Aged; Multivariate Analysis; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2015 |
Therapy with boceprevir or telaprevir in HIV/hepatitis C virus co-infected patients to treat recurrence of hepatitis C virus infection after liver transplantation.
Topics: Adult; Antiviral Agents; Coinfection; Cyclosporine; Drug Therapy, Combination; Female; Hepatitis C, Chronic; HIV Infections; Humans; Immunosuppression Therapy; Interferon alpha-2; Interferon-alpha; Liver Transplantation; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Tacrolimus; Viral Load | 2015 |
Performance of two HCV RNA assays during protease inhibitor-based triple therapy in patients with advanced liver fibrosis and cirrhosis.
Topics: Anti-Retroviral Agents; Clinical Laboratory Techniques; Europe; Genotype; Hepacivirus; Hepatitis C; Humans; Liver Cirrhosis; Oligopeptides; Predictive Value of Tests; Proline; Protease Inhibitors; Reproducibility of Results; RNA, Viral; Treatment Outcome; Viremia | 2014 |
Predictive value of interferon-lambda gene polymorphisms for treatment response in chronic hepatitis C.
Topics: Antiviral Agents; Drug Monitoring; Gene Expression Regulation; Genotype; Hepacivirus; Hepatitis C, Chronic; Host-Pathogen Interactions; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Polyethylene Glycols; Polymorphism, Single Nucleotide; Prognosis; Proline; Recombinant Proteins; Ribavirin; Signal Transduction; Treatment Outcome | 2014 |
Uptake and utilization of directly acting antiviral medications for hepatitis C infection in U.S. veterans.
Topics: Antiviral Agents; Drug Therapy, Combination; Drug Utilization; Genotyping Techniques; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Oligopeptides; Proline; Retrospective Studies; Ribavirin; United States; Veterans | 2015 |
Provider Workforce Assessment in a Rural Hepatitis C Epidemic: Implications for Scale-up of Antiviral Therapy.
Topics: Antiviral Agents; Health Services Accessibility; Hepatitis C; Humans; Oligopeptides; Practice Patterns, Physicians'; Primary Health Care; Proline; Rural Health; Rural Health Services; Wisconsin | 2015 |
Boceprevir and telaprevir-based regimens for the treatment of hepatitis C virus in HIV/HCV coinfected patients.
Topics: Aged; Antiviral Agents; Coinfection; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis C, Chronic; HIV Infections; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Ribavirin; Treatment Outcome; Veterans | 2015 |
Virologic response and haematologic toxicity of boceprevir- and telaprevir-containing regimens in actual clinical settings.
Topics: Aged; Anemia; Antiviral Agents; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Neutropenia; Oligopeptides; Proline; RNA, Viral; Thrombocytopenia; Treatment Outcome; Viral Load | 2015 |
Patients treated with first-generation HCV protease inhibitors exhibit high ribavirin concentrations.
Topics: Adult; Aged; Anemia; Antiviral Agents; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hemoglobins; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Retrospective Studies; Ribavirin | 2015 |
Hepatitis C virus RNA levels at week-2 of telaprevir/boceprevir administration are predictive of virological outcome.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Prognosis; Proline; Ribavirin; RNA, Viral; Treatment Outcome; Viral Load | 2015 |
Early virological assessment during telaprevir- or boceprevir-based triple therapy in hepatitis C cirrhotic patients who failed a previous interferon based regimen - The ANRS CO20-CUPIC study.
Topics: Antiviral Agents; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA; Viral Load | 2015 |
Triple therapy with boceprevir or telaprevir in a European cohort of cirrhotic HIV/HCV genotype 1-coinfected patients.
Topics: Anemia; Antiviral Agents; Cohort Studies; Coinfection; Drug Therapy, Combination; Female; France; Genotype; Germany; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Italy; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Oligopeptides; Proline; Ribavirin; RNA, Viral; Treatment Outcome | 2015 |
Telaprevir- and Boceprevir-based Triple Therapy for Hepatitis C in Liver Transplant Recipients With Advanced Recurrent Disease: A Multicenter Study.
Topics: Antiviral Agents; Biomarkers; Cholestasis; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Liver Cirrhosis; Liver Transplantation; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Oligopeptides; Proline; Recurrence; Retrospective Studies; Risk Factors; RNA, Viral; Time Factors; Treatment Outcome; United States; Viral Load | 2015 |
Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort.
Topics: Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Mutation; Oligopeptides; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Proline; Scotland; Sequence Analysis, DNA; Simeprevir; Viral Nonstructural Proteins | 2015 |
Treatment patterns, health care resource utilization, and costs in U.S. patients diagnosed with chronic hepatitis C infection who received telaprevir or boceprevir.
Topics: Antiviral Agents; Female; Health Care Costs; Health Resources; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Practice Patterns, Physicians'; Proline; Retrospective Studies; United States | 2015 |
Poor Sustained Virological Response in a Multicenter Real-Life Cohort of Chronic Hepatitis C Patients Treated with Pegylated Interferon and Ribavirin plus Telaprevir or Boceprevir.
Topics: Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferons; Male; Medication Adherence; Middle Aged; Oligopeptides; Proline; Retrospective Studies; Ribavirin; Treatment Outcome; Young Adult | 2015 |
First-generation protease inhibitor-triple therapy: SVR 24, safety, and predictors of response in a large single center cohort.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies | 2015 |
Boceprevir or Telaprevir Based Triple Therapy against Chronic Hepatitis C in HIV Coinfection: Real-Life Safety and Efficacy.
Topics: Adult; Coinfection; Drug-Related Side Effects and Adverse Reactions; Europe; Female; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Proline; Ribavirin; Treatment Outcome | 2015 |
Naturally Occurring Resistance-Associated Variants of Hepatitis C Virus Protease Inhibitors in Poor Responders to Pegylated Interferon-Ribavirin.
Topics: Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Interferon-alpha; Male; Middle Aged; Mutation, Missense; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies; Ribavirin; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
Direct costs of first-generation protease inhibitors for the treatment of genotype 1 chronic hepatitis C viral infection.
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Health Care Costs; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Ribavirin; Tertiary Care Centers; Treatment Outcome; Viral Load | 2015 |
Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment.
Topics: Adolescent; Adult; Aged; Anemia; Antiviral Agents; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Hepatitis C, Chronic; Humans; Incidence; Male; Membrane Transport Proteins; Middle Aged; Oligopeptides; Proline; Prospective Studies; Protease Inhibitors; Pyrophosphatases; Ribavirin; Risk Assessment; Young Adult | 2015 |
Protease inhibitors-based therapy induces acquired spherocytic-like anaemia and ineffective erythropoiesis in chronic hepatitis C virus patients.
Topics: Adult; Aged; Anemia; Antiviral Agents; Drug Monitoring; Drug Therapy, Combination; Erythrocyte Indices; Erythrocyte Membrane; Erythropoiesis; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Protease Inhibitors; Pyrophosphatases; Ribavirin; Treatment Outcome | 2016 |
Costs and Resource Utilization Associated With Anemia and Rash in Chronic Hepatitis C Patients Treated With Direct-Acting Antiviral Agents in the United States.
Topics: Adult; Aged; Anemia; Antiviral Agents; Databases, Factual; Drug Costs; Drug Eruptions; Drug Therapy, Combination; Female; Health Care Costs; Health Resources; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Ribavirin; United States | 2015 |
THE ABSENCE OF THYROID DISEASE IN AN AUSTRALIAN HEPATITIS C COHORT TREATED WITH TRIPLE COMBINATION THERAPY: A PARADIGM SHIFT.
Topics: Adult; Australia; Case-Control Studies; Drug Therapy, Combination; Female; Hepatitis C; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies; Ribavirin; Thyroid Diseases | 2015 |
Belgian experience with triple therapy with boceprevir and telaprevir in genotype 1 infected patients who inject drugs.
Topics: Adult; Antiviral Agents; Belgium; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Retrospective Studies; Ribavirin; Substance Abuse, Intravenous; Treatment Outcome | 2016 |
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cohort Studies; Female; Hepatitis C, Chronic; HIV Infections; Humans; Leucine; Male; Middle Aged; Oligopeptides; Patient Acceptance of Health Care; Proline; Prospective Studies; Protease Inhibitors; Quinolines; RNA, Viral; Switzerland; Thiazoles; Viral Load | 2015 |
Examining Hepatitis C Virus Treatment Preference Heterogeneity Using Segmentation Analysis: Treat Now or Defer?
Topics: Aged; Antiviral Agents; Black or African American; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon Type I; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Patient Preference; Polyethylene Glycols; Proline; Ribavirin; Surveys and Questionnaires; White People | 2016 |
The CUPIC algorithm: an accurate model for the prediction of sustained viral response under telaprevir or boceprevir triple therapy in cirrhotic patients.
Topics: Algorithms; Antiviral Agents; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Models, Theoretical; Oligopeptides; Polyethylene Glycols; Proline; Random Allocation; Ribavirin; Treatment Outcome; Viral Load | 2015 |
T-cell homeostasis in chronic HCV-infected patients treated with interferon and ribavirin or an interferon-free regimen.
Topics: Adult; Aged; Amides; Antiviral Agents; Apoptosis; Benzofurans; Carbamates; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclopropanes; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Interferon-alpha; Interleukin-7 Receptor alpha Subunit; Lipopolysaccharides; Lymphocyte Count; Lymphopenia; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Quinoxalines; Recombinant Proteins; Ribavirin; Sulfonamides | 2015 |
UPLC-MS/MS method with automated on-line SPE for the isomer-specific quantification of the first-generation anti-HCV protease inhibitors in peripheral blood mononuclear cells.
Topics: Antiviral Agents; Automation, Laboratory; Chromatography, Liquid; Drug Monitoring; Hepatitis C; Humans; Isomerism; Leukocytes, Mononuclear; Limit of Detection; Linear Models; Oligopeptides; Proline; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Time Factors | 2015 |
Favourable SVR12 rates with boceprevir or telaprevir triple therapy in HIV/HCV coinfected patients.
Topics: Adult; Antiviral Agents; Coinfection; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Sustained Virologic Response | 2015 |
[Cost-effectiveness and safety of telaprevir and boceprevir for chronic hepatitis C in real-world clinical practice].
Topics: Antiviral Agents; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Emergency Service, Hospital; Female; Hematologic Diseases; Hepatitis C, Chronic; Hospitalization; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Remission Induction; Retrospective Studies; Ribavirin; Spain | 2015 |
Successful treatment of chronic hepatitis C with triple therapy in an opioid agonist treatment program.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Opiate Substitution Treatment; Polyethylene Glycols; Proline; Recombinant Proteins; Retrospective Studies; Ribavirin; Substance Abuse, Intravenous; Treatment Outcome | 2015 |
Ribavirin concentration determines treatment success of first-generation DAA-based chronic HCV therapy.
Topics: Anemia; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Oligopeptides; Proline; Ribavirin | 2016 |
Multicenter Experience with Boceprevir or Telaprevir to Treat Hepatitis C Recurrence after Liver Transplantation: When Present Becomes Past, What Lessons for Future?
Topics: Adult; Aged; Anemia; Antiviral Agents; Combined Modality Therapy; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Host-Pathogen Interactions; Humans; Interferon-alpha; Liver Transplantation; Male; Middle Aged; Multivariate Analysis; Oligopeptides; Polyethylene Glycols; Postoperative Period; Proline; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Recurrence; Thrombocytopenia; Treatment Outcome | 2015 |
Effectiveness of first-generation HCV protease inhibitors: does HIV coinfection still play a role?
Topics: Adult; Antiviral Agents; Coinfection; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Interferons; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Protease Inhibitors; Ribavirin; RNA, Viral; Viral Load | 2016 |
Development and persistence of DAA resistance associated mutations in patients failing HCV treatment.
Topics: Antiviral Agents; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Mutation, Missense; Oligopeptides; Proline; Sequence Analysis, DNA; Treatment Failure; Viral Nonstructural Proteins | 2015 |
Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.
Topics: Adenine; Alanine; Anti-HIV Agents; Biotransformation; Carboxylic Ester Hydrolases; Cathepsin A; CD4-Positive T-Lymphocytes; Cobicistat; Drug Interactions; Gene Expression; HEK293 Cells; HeLa Cells; HIV-1; Host-Pathogen Interactions; Humans; Oligopeptides; Primary Cell Culture; Prodrugs; Proline; RNA, Small Interfering; Serine Proteinase Inhibitors; Tenofovir | 2016 |
Renal impairment in patients with chronic hepatitis C treated with first generation protease inhibitors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Therapy, Combination; Female; Hemoglobins; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Recombinant Proteins; Renal Insufficiency; Retrospective Studies; Ribavirin; Risk Factors; Time Factors; Young Adult | 2015 |
HCV viral load at baseline and at week 4 of telaprevir/boceprevir based triple therapies are associated with virological outcome in HIV/hepatitis C co-infected patients.
Topics: Antiviral Agents; Coinfection; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Ribavirin; Treatment Outcome; Viral Load | 2015 |
Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.
Topics: Anemia; beta 2-Glycoprotein I; Drug Therapy, Combination; Hemoglobins; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Liver Cirrhosis; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Pyrophosphatases; Treatment Outcome | 2015 |
Protease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic hepatitis C.
Topics: Adult; Aged; Antiviral Agents; Biopsy; Female; Gene Expression Profiling; Hepatitis C, Chronic; Hepatocytes; Humans; Interferon-alpha; Liver; Macrophages; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Ribavirin; Staining and Labeling | 2016 |
Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3/4A Protease Activity.
Topics: Animals; Computer Systems; Disease Models, Animal; Hepacivirus; Liver; Luciferases; Mice, Transgenic; Oligopeptides; Plasmids; Proline; Protease Inhibitors; Reproducibility of Results; Viral Nonstructural Proteins | 2016 |
Clinical relevance of the HCV protease inhibitor-resistant mutant viral load assessed by ultra-deep pyrosequencing in treatment failure.
Topics: Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Mutation; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies; Treatment Failure; Viral Load | 2016 |
[Resistance to protease inhibitors and efficiency of antiviral therapy in patients with chronic hepatitis C].
Topics: Adult; Aged; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Young Adult | 2016 |
Estimated glomerular filtration rate but not solute carrier polymorphisms influences anemia in HIV-hepatitis C virus coinfected patients treated with boceprevir or telaprevir-based therapy.
Topics: Anemia; Antiviral Agents; Coinfection; Decision Support Techniques; Drug Therapy, Combination; Female; Genotyping Techniques; Glomerular Filtration Rate; Hepatitis C, Chronic; HIV Infections; Humans; Male; Membrane Transport Proteins; Oligopeptides; Pharmacogenomic Testing; Polymorphism, Single Nucleotide; Proline; Ribavirin | 2016 |
Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents.
Topics: Algorithms; Antiviral Agents; Cell Line; Drug Resistance, Viral; Genetic Association Studies; Genome, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Internet; Mutation; Oligopeptides; Phenotype; Proline; Simeprevir; Software | 2016 |
Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors.
Topics: Adult; Aged; Anemia; Antiviral Agents; Female; Glomerular Filtration Rate; Hepatitis C, Chronic; Humans; Interferon-alpha; Logistic Models; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Protease Inhibitors; Recombinant Proteins; Ribavirin; Risk Factors; Severity of Illness Index; Statistics, Nonparametric; Sustained Virologic Response; Time Factors; Treatment Failure; Young Adult | 2016 |
Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C.
Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Mutation; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Turkey; Viral Nonstructural Proteins; Young Adult | 2016 |
[FIRST GENERATION PROTEASE INHIBITOR BASED TRIPLE THERAPY FOR HCV GENOTYPE 1--LOOKING BACK WHILE PROCEEDING TO A PROMISING ERA].
Topics: Adult; Antiviral Agents; DNA, Viral; Drug Carriers; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Israel; Male; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Retrospective Studies; Ribavirin; Treatment Outcome | 2016 |
Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients.
Topics: Antiviral Agents; Drug Resistance, Viral; Hepacivirus; High-Throughput Nucleotide Sequencing; Humans; Mutation; Oligopeptides; Proline; Simeprevir; Viral Nonstructural Proteins | 2016 |
The Role of Hepatitis C Virus Core Antigen Testing in the Era of Direct Acting Antiviral Therapies: What We Can Learn from the Protease Inhibitors.
Topics: Adult; Aged; Antiviral Agents; Female; Hepacivirus; Hepatitis C Antigens; Humans; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors | 2016 |
The number of patients with chronic hepatitis C in times of new therapy options: a retrospective observational study on German health insurance funds data.
Topics: Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Germany; Hepatitis C, Chronic; Humans; Incidence; Insurance, Health; Male; Middle Aged; Oligopeptides; Prevalence; Proline; Retrospective Studies | 2017 |
Shift in disparities in hepatitis C treatment from interferon to DAA era: A population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; British Columbia; Cohort Studies; Female; Healthcare Disparities; Hepatitis C, Chronic; Humans; Interferons; Male; Middle Aged; Oligopeptides; Proline; Ribavirin; Young Adult | 2017 |
Effectiveness of triple therapy with direct-acting antivirals for hepatitis C genotype 1 infection: application of propensity score matching in a national HCV treatment registry.
Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Ireland; Male; Middle Aged; Oligopeptides; Proline; Propensity Score; Prospective Studies; Registries; Ribavirin; Treatment Outcome; Uncertainty | 2017 |
The frequency of acute kidney injury in patients with chronic hepatitis C virus infection treated with sofosbuvir-based regimens.
Topics: Acute Kidney Injury; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Male; Middle Aged; Oligopeptides; Proline; Risk Factors; Sofosbuvir | 2017 |
Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning.
Topics: Amino Acid Substitution; Antiviral Agents; Bayes Theorem; Carrier Proteins; Cohort Studies; Databases, Genetic; Drug Resistance, Viral; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Mutation, Missense; Oligopeptides; Proline; Protease Inhibitors; RNA, Viral; Viral Nonstructural Proteins | 2017 |
Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort.
Topics: Adult; Aged; Antiviral Agents; Autoantibodies; Drug Monitoring; Female; Fluorescent Antibody Technique, Indirect; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; IMP Dehydrogenase; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Treatment Outcome | 2017 |
Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.
Topics: Adaptive Immunity; Antibodies, Viral; Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Proliferation; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Immunity, Innate; Immunologic Memory; Interferon-alpha; Longitudinal Studies; Lymphocyte Activation; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Prospective Studies; Recombinant Proteins; Ribavirin; T-Box Domain Proteins; Treatment Outcome | 2018 |
The effect of the first-generation HCV-protease inhibitors boceprevir and telaprevir and the relation to baseline NS3 resistance mutations in genotype 1: experience from a small Swedish cohort.
Topics: Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis C; Humans; Middle Aged; Mutation; Oligopeptides; Proline; Protease Inhibitors; Retrospective Studies; Viral Nonstructural Proteins | 2018 |
Effectiveness and Cost-Effectiveness of Triple Therapy With Telaprevir and Boceprevir for Chronic Hepatitis C: A Decision Analysis From the Brazilian Public Health System Perspective.
Topics: Antiviral Agents; Brazil; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Health Care Costs; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Markov Chains; Middle Aged; Oligopeptides; Proline; Public Health Practice; Quality-Adjusted Life Years; Ribavirin; Treatment Outcome | 2019 |
Cost-effectiveness analysis is a mandatory strategy for health systems: evidence from a study involving therapies for hepatitis C.
Topics: Antiviral Agents; Brazil; Cost-Benefit Analysis; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Oligopeptides; Polyethylene Glycols; Proline; Quality-Adjusted Life Years; Recombinant Proteins; Ribavirin | 2020 |
Increased mortality in HIV/HCV-coinfected compared to HCV-monoinfected patients in the DAA era due to non-liver-related death.
Topics: Antiviral Agents; Cause of Death; Disease Progression; Female; France; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Liver Cirrhosis; Male; Middle Aged; Mortality; Oligopeptides; Proline; Substance-Related Disorders; Sustained Virologic Response | 2021 |
SARS-CoV-2 M
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chemokine CXCL10; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Design; Humans; Interferon-beta; Lung; Mice; Mice, Transgenic; Oligopeptides; Proline; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Viral Load; Virus Replication | 2021 |
Targeted design of drug binding sites in the main protease of SARS-CoV-2 reveals potential signatures of adaptation.
Topics: Adaptation, Physiological; Amino Acid Sequence; Antiviral Agents; Binding Sites; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Drug Design; Drug Resistance, Viral; Genetic Fitness; Hepacivirus; Ligands; Models, Molecular; Mutation; Oligopeptides; Proline; Reproducibility of Results; SARS-CoV-2; Selection, Genetic; Structure-Activity Relationship | 2021 |