proline and piperidines

proline has been researched along with piperidines in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-19909 (14.06)18.7374
1990's20 (31.25)18.2507
2000's20 (31.25)29.6817
2010's14 (21.88)24.3611
2020's1 (1.56)2.80

Authors

AuthorsStudies
Sen, NP; Stoltz, DR1
Hussain, T; Ravindran, B1
Hitoshi, T; Ijima, S; Iwamura, H; Kadota, T; Matsuda, A; Miyata, T; Nagata, J; Naka, M; Okano, Y; Takahama, K1
Garcia, H; Lijinsky, W1
Grant, G; Ling, N; Rivier, J; Vale, W1
Greenblatt, M; Lijinsky, W1
Flavin, M; Sharpless, NE1
Cizmárik, J; Svec, J; Svec, P1
Brechtel, C; Fleming, SR; King, SC1
Maggio, R; Nanavati, S; Vogel, Z; Wess, J1
Bilgili, SF; Hess, JB; Pinion, JL1
Abdel-Ghany, Y; Kunin, CM; LeRudulier, D; Miller, DD; Poggi, MC; Tong, HH1
Granot, I; Halevy, O; Hurwitz, S; Pines, M1
Buhr, RJ; Christensen, KD; Goodman, TN; Twining, PF; Wyatt, CL; Zimmermann, NG1
Gallard, JF; Guittet, E; Le, HT; Mayer, M; Michelot, R1
Egebjerg, J; Sørensen, PO; Thomsen, C1
Itoh, Y; Kimura, K; Oka, M; Shimidzu, T; Ukai, Y; Yoshikuni, Y1
Itoh, Y; Kimura, K; Ma, FH; Oka, M; Tatsumi, S; Ukai, Y; Yoshikuni, Y1
Aingorn, H; Condiotti, R; Genina, O; Katz, A; Miao, HQ; Nagler, A; Pines, M; Vlodavsky, I1
Ishima, T; Itoh, Y; Kimura, K; Oka, M; Shimidzu, T; Ukai, Y; Yoshikuni, Y1
Campbell, EA; Gentry, CT; Panesar, MS; Patel, S; Urban, L; Walpole, CS1
Isawa, S; Kumagai, Y; Miyatake, S; Mukai, H; Murasaki, M; Yokota, S1
Itoh, Y; Kimura, K; Kise, M; Mushiroi, T; Ogasawara, T; Tamura, M; Ukai, Y1
Ago, M; Morino, A; Mukai, H; Sugimoto, T1
Hirouchi, M; Itoh, Y; Kimura, K; Oka, M; Ukai, Y1
Ago, M; Esumi, Y; Matsuura, C; Morino, A; Mukai, H; Ogawa, Y; Seki, H; Sugimoto, T; Takaichi, M1
Falkiewicz, B1
Campbell, EA; Cruwys, S; Fox, AJ; Gentry, C; Kidd, B; Patel, S; Urban, L1
Davis, FA; Fang, T; Goswami, R1
Efange, SM; Luine, VN; Mohan, G; Tu, Z1
BUCKLEY, SD; MEISTER, A; RADHAKRISHNAN, AN1
Kinsella, BT; O'Meara, SJ1
Bojarski, AJ; Duszyńska, B; Martinez, J; Pawłowski, M; Subra, G; Zajdel, P1
Ganesh, KN; Kumar, VA1
Baldwin, JJ; Chiba, J; Hussain, Z; Machinaga, N; McDonald, E; Moriarty, KJ; Nakayama, A; Saionz, KW; Sarko, CR; Swanson, R; Takashi, T; Takayama, G; Wong, A; Yokoyama, M1
Arai-Otsuki, S; Goto, Y; Ichikawa, D; Iwasawa, Y; Ohta, H; Okamoto, O; Okuda, S; Ozaki, S; Sagara, T; Tachibana, Y; Takahashi, H1
Chandrasekaran, A; Kolmakova, NG; Ojeda, AM; Parsons, SM1
Augustyns, K; Brandt, I; Chen, X; Cheng, JD; De Meester, I; Dubois, V; Lambeir, AM; Maes, MB; Scharpé, S; Van der Veken, P1
Jhon, JS; Kang, YK1
Fuchigami, T; Kurihara, H; Tajima, T1
Gribkov, DV; Pastine, SJ; Sames, D; Schnürch, M1
Gong, Y; Peng, Y; Zhang, F1
Einsiedel, J; Gmeiner, P; Heinemann, FW; Lomlim, L; Meyer, K1
Gotoh, H; Hayashi, Y; Ishikawa, H; Masui, R1
Carlson, EC; Carter, RG; Collett, ND; Rathbone, LK; Yang, H1
Fichna, J; Gach, K; Janecka, A; Poels, J; Staniszewska, R; Toth, G; Vanden Broeck, J1
Hasserodt, J; Waibel, M1
Bermúdez, E; Saenz Méndez, P; Ventura, ON1
Bella, M; Monaco, MR; Renzi, P; Scarpino Schietroma, DM1
Brookfield, FA; Courtney, SM; Dominguez, C; Eustache, FM; Gemkow, MJ; Handel, RK; Johnson, LC; Johnson, PD; Kerry, MA; Krieger, F; Maillard, MC; Meniconi, M; Muñoz-Sanjuán, I; Palfrey, JJ; Park, H; Schaertl, S; Taylor, MG; Weddell, D1
Charlip, A; Chu, T; Gallinetti, J; Mejia, P; Mitchell, JR; Peng, W; Robertson, L; Vose, S1
Schimmel, P; Sun, L; Yang, XL; Zhou, H1
Chu, TL; Du, C; Guan, Q; Nguan, CY2
Hwang, KY; Jeon, YH; Kim, J; Kim, JH; Kim, S; Lee, EH; Park, M; Son, J1
Antoun, Z; Bidault, R; Cossy, J; Gomez Pardo, D; Orliac, A; Rioton, S1
Castillo, JJ; Ghobrial, IM; Treon, SP1
Harmsen, B; Leyssens, T; Robeyns, K; Wouters, J1
Gao, F; Li, F; Li, XY; Liu, ST; Miao, Y; Sun, XH; Wang, X; Wang, Z; Yang, XL; Zhang, ML; Zhong, SM; Zhu, K1
Göttemann, LT; Kuroda, Y; Roque, JB; Sarpong, R1
Bopp, SE; Clish, CB; Deik, AA; Fagbami, L; Herman, JD; Lukens, AK; Mazitschek, R; Santos, SA; Singh, K; Wirth, DF1
Bertolotti, A; Peak-Chew, SY; Pitera, AP; Szaruga, M; Wingett, SW1

Trials

1 trial(s) available for proline and piperidines

ArticleYear
Comparison of pharmacokinetics of NS-105, a novel agent for cerebrovascular disease, in elderly and young subjects.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:1

    Topics: Adult; Age Factors; Aged; Analysis of Variance; Area Under Curve; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Humans; Kidney; Least-Squares Analysis; Linear Models; Male; Metabolic Clearance Rate; Nootropic Agents; Piperidines; Proline

1999

Other Studies

63 other study(ies) available for proline and piperidines

ArticleYear
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: some N-nitroso compounds.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1978, Volume: 17

    Topics: Animals; Butylamines; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Ethanolamines; Ethylamines; Ethylnitrosourea; Folic Acid; Humans; Methylamines; Methylnitrosourea; Morpholines; Nicotine; Nitrosamines; Nitroso Compounds; Piperidines; Proline; Propylamines; Research Design; Sarcosine; Streptozocin

1978
Mutagenicity of five cyclic N-nitrosamines: assay with Salmonella typhimurium.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:2

    Topics: Hydroxyproline; In Vitro Techniques; Microsomes, Liver; Mutagens; Nitrosamines; Piperidines; Proline; Pyrrolidines; Salmonella typhimurium; Structure-Activity Relationship

1977
Antigenic mimicry between piperazine derivatives and Wuchereria bancrofti microfilariae.
    Acta tropica, 1992, Volume: 50, Issue:4

    Topics: Animals; Antibodies, Helminth; Cross Reactions; Diethylcarbamazine; Enzyme-Linked Immunosorbent Assay; Haptens; Microfilariae; Nipecotic Acids; Piperazines; Piperidines; Proline; Wuchereria bancrofti

1992
Imino acid and related alicyclic amine levels in biological fluids.
    Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:7

    Topics: Amines; Animals; Body Fluids; Female; Gas Chromatography-Mass Spectrometry; Humans; Imino Acids; Male; Pipecolic Acids; Piperidines; Proline; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains

1985
Studies of the tumorigenic effect in feeding of nitrosamino acids and of low doses of amines and nitrite to rats.
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1973, May-07, Volume: 79, Issue:3

    Topics: Animals; Carcinogens; Hydroxyproline; Imines; Morpholines; Nitrites; Nitroso Compounds; Pipecolic Acids; Piperazines; Piperidines; Proline; Pyrrolidines; Rats; Water

1973
Orientation restrictions of the peptide hormone, thyrotropin-releasing factor, due to intramolecular hydrogen bonding.
    Biochemistry, 1972, Aug-01, Volume: 11, Issue:16

    Topics: Alkylation; Glutamates; Histidine; Hydrogen-Ion Concentration; Imidazoles; Methylation; Models, Chemical; Piperidines; Potentiometry; Proline; Pyrrolidines; Structure-Activity Relationship; Thyrotropin-Releasing Hormone

1972
Failure to induce tumors in Swiss mice after concurrent administration of amino acids and sodium nitrite.
    Journal of the National Cancer Institute, 1972, Volume: 48, Issue:5

    Topics: Adenoma; Animals; Arginine; Carcinogens; Female; Hydroxyproline; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrites; Nitroso Compounds; Piperidines; Proline; Pyrrolidines

1972
The reactions of amines and amino acids with maleimides. Structure of the reaction products deduced from infrared and nuclear magnetic resonance spectroscopy.
    Biochemistry, 1966, Volume: 5, Issue:9

    Topics: Amides; Amines; Chemical Phenomena; Chemistry, Physical; Ethylmaleimide; Imides; Infrared Rays; Magnetic Resonance Spectroscopy; Piperidines; Proline; Pyrrolidines; Spectrum Analysis

1966
In vitro cytotoxicity in rabbit corneal cells of two new local anesthetics--pentacaine and heptacaine.
    Die Pharmazie, 1981, Volume: 36, Issue:12

    Topics: Anesthetics, Local; Animals; Carbamates; Cornea; In Vitro Techniques; Piperidines; Proline; Rabbits; Thymidine; Trimecaine

1981
Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP.
    Journal of bacteriology, 1995, Volume: 177, Issue:18

    Topics: Biological Transport; Escherichia coli; Escherichia coli Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Genes, Bacterial; Membrane Transport Modulators; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Substrate Specificity

1995
Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor.
    The EMBO journal, 1993, Volume: 12, Issue:1

    Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Carbachol; Cell Line; Codon; GTP-Binding Proteins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Parasympatholytics; Piperidines; Proline; Protein Conformation; Rats; Receptors, Muscarinic; Recombinant Proteins; Restriction Mapping; RNA; Scopolamine Derivatives; Transfection; Tryptophan

1993
The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of female broilers: influence of a high-proline diet supplemented with ascorbic acid and zinc.
    Poultry science, 1995, Volume: 74, Issue:2

    Topics: Animals; Ascorbic Acid; Body Weight; Chickens; Coccidiostats; Female; Food, Fortified; Piperidines; Proline; Pyrans; Quinazolines; Quinazolinones; Skin; Skin Physiological Phenomena; Tensile Strength; Zinc

1995
Effect of novel compound, 1-methyl-1-piperidino methane sulfonate (MPMS), on the osmoprotectant activity of glycine betaine, choline and L-proline in Escherichia coli.
    Archives of microbiology, 1993, Volume: 160, Issue:2

    Topics: Azetidinecarboxylic Acid; Betaine; Biological Transport; Choline; Escherichia coli; Mesylates; Piperidines; Proline; Sodium Chloride; Water-Electrolyte Balance

1993
Halofuginone: an inhibitor of collagen type I synthesis.
    Biochimica et biophysica acta, 1993, Feb-13, Volume: 1156, Issue:2

    Topics: Animals; Birds; Cell Division; Cells, Cultured; Coccidiostats; Collagen; Embryo, Mammalian; Embryo, Nonmammalian; Fibroblasts; Gene Expression; Growth Plate; Matrix Metalloproteinase Inhibitors; Mice; Piperidines; Proline; Quinazolines; Quinazolinones; Rats; Species Specificity

1993
Mitigating the effects of halofuginone on skin strength by feeding L-proline to broiler chickens.
    Poultry science, 1995, Volume: 74, Issue:10

    Topics: Animals; Body Weight; Chickens; Coccidiostats; Collagen; Female; Food, Fortified; Male; Piperidines; Proline; Quinazolines; Quinazolinones; Skin; Skin Physiological Phenomena; Tensile Strength

1995
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:12

    Topics: Amino Acids; Cross-Linking Reagents; Imines; Leucine; Models, Chemical; Organophosphorus Compounds; Oxazoles; Phosphorus; Piperidines; Proline; Sulfhydryl Compounds; Thioamides

1996
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
    British journal of pharmacology, 1997, Volume: 120, Issue:6

    Topics: Animals; Carrier Proteins; Cell Line; Cricetinae; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Tiagabine

1997
Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain.
    Brain research, 1997, Apr-18, Volume: 754, Issue:1-2

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine

1997
A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:2

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cells, Cultured; Cerebral Cortex; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Mice; Neurons; Pertussis Toxin; Piperidines; Proline; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella

1997
Inhibition of glomerular mesangial cell proliferation and extracellular matrix deposition by halofuginone.
    Kidney international, 1997, Volume: 52, Issue:6

    Topics: Animals; Carbon Radioisotopes; Cell Division; Cells, Cultured; Collagen; Extracellular Matrix; Gene Expression; Glomerular Mesangium; Piperidines; Proline; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Sulfates; Tritium

1997
Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment.
    European journal of pharmacology, 1997, Nov-12, Volume: 338, Issue:3

    Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depressive Disorder; Male; Microdialysis; Norepinephrine; Piperidines; Proline; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, GABA-B; Receptors, Serotonin; Serotonin; Synaptosomes

1997
Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig.
    Neuroscience, 1998, Volume: 87, Issue:3

    Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Naphthalenes; Nerve Fibers; Neuralgia; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Proline; Receptors, Neurokinin-1; Spinal Cord

1998
Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 64, Issue:1

    Topics: Acetylcholine; Animals; Avoidance Learning; Basal Ganglia; Cerebral Cortex; Cognition; Electroshock; gamma-Aminobutyric Acid; Male; Memory Disorders; Muscarinic Antagonists; Nootropic Agents; Parasympathetic Nervous System; Piperidines; Proline; Rats; Rats, Wistar; Receptors, GABA-B; Scopolamine; Synaptosomes

1999
Pharmacokinetics of NS-105, a novel cognition enhancer. 1st communication: absorption, metabolism and excretion in rats, dogs and monkeys after single administration of 14C-NS-105.
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:11

    Topics: Administration, Oral; Animals; Bile; Biotransformation; Blood Proteins; Dogs; Feces; Female; Food-Drug Interactions; Injections, Intravenous; Intestinal Absorption; Lymph; Macaca fascicularis; Male; Nootropic Agents; Piperidines; Proline; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Characteristics

1999
Role of metabotropic glutamate receptor subclasses in modulation of adenylyl cyclase activity by a nootropic NS-105.
    European journal of pharmacology, 2000, Jan-03, Volume: 387, Issue:1

    Topics: Adenylyl Cyclases; Animals; Benzoates; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation; Glycine; Male; Membranes; Neurons; Nootropic Agents; Oligodeoxyribonucleotides, Antisense; Oligonucleotides; Piperidines; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger

2000
Pharmacokinetics of NS-105, a novel cognition enhancer. 2nd communication: distribution and transfer into fetus and milk after single administration, and effects of repeated administration on pharmacokinetics and hepatic drug-metabolizing enzyme activitie
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:12

    Topics: Animals; Feces; Female; Fetus; Intestinal Absorption; Liver; Male; Maternal-Fetal Exchange; Milk; Nootropic Agents; Piperidines; Placenta; Pregnancy; Proline; Rats; Rats, Sprague-Dawley; Sex Characteristics; Tissue Distribution

1999
Comparison of the efficiency of various coupling systems in the acylation of model secondary amines with thymin-1-ylacetic acid.
    Nucleic acids symposium series, 1999, Issue:42

    Topics: Acetates; Acylation; Amines; Carbodiimides; Hydrocarbons, Brominated; Indicators and Reagents; Peptide Nucleic Acids; Piperidines; Proline; Thymine

1999
Fasoracetam. LAM 105, NS 105.
    Drugs in R&D, 1999, Volume: 2, Issue:2

    Topics: Animals; Clinical Trials as Topic; Cognition Disorders; Humans; Nootropic Agents; Piperidines; Proline; Rats; Rats, Wistar

1999
Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.
    Pain, 2000, Volume: 87, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Female; Freund's Adjuvant; Guinea Pigs; Humans; Hyperalgesia; Indoles; Isoindoles; Male; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Proline; Quinuclidines

2000
Asymmetric synthesis of substituted prolines from delta-amino beta-ketoesters. Methyl (2S,5R)-(+)-5-phenylpyrrolidine-2-carboxylate.
    Organic letters, 2002, May-02, Volume: 4, Issue:9

    Topics: Cholecystokinin; Indicators and Reagents; Keto Acids; Piperidines; Proline; Stereoisomerism

2002
Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: Animals; Benzopyrans; Cholinesterase Inhibitors; Donepezil; Female; Indans; Memory; Nicotinic Agonists; Ovariectomy; Piperidines; Proline; Rats; Rats, Sprague-Dawley; Space Perception; Stimulation, Chemical; Visual Perception

2002
Enzymatic synthesis of L-pipecolic acid and L-proline.
    The Journal of biological chemistry, 1957, Volume: 229, Issue:2

    Topics: Pipecolic Acids; Piperidines; Proline

1957
The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
    The Biochemical journal, 2005, Feb-15, Volume: 386, Issue:Pt 1

    Topics: Adrenergic beta-Agonists; Alkyl and Aryl Transferases; Amino Acid Motifs; Animals; Calcium Signaling; Carrier Proteins; Cell Line; Cell Line, Tumor; Cyclic AMP; Dose-Response Relationship, Drug; Endocytosis; Epoprostenol; Farnesyltranstransferase; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; Humans; Iloprost; Isoproterenol; Kidney; Leukemia, Erythroblastic, Acute; Mice; Mutagenesis, Site-Directed; Organophosphorus Compounds; Piperidines; Proline; Propanolamines; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Pyridines; Receptors, Adrenergic, beta-2; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Recombinant Fusion Proteins; Signal Transduction; Transfection

2005
Parallel solid-phase synthesis and characterization of new sulfonamide and carboxamide proline derivatives as potential CNS agents.
    Bioorganic & medicinal chemistry, 2005, Apr-15, Volume: 13, Issue:8

    Topics: Amides; Binding, Competitive; Central Nervous System Agents; Ligands; Molecular Structure; Piperidines; Proline; Pyrrolidines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Receptors, Serotonin; Sulfonamides; Tosyl Compounds

2005
Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity.
    Accounts of chemical research, 2005, Volume: 38, Issue:5

    Topics: Amino Acid Sequence; Directed Molecular Evolution; DNA; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Nucleic Acids; Piperidines; Proline; Pyrrolidines; RNA; Substrate Specificity

2005
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
    Bioorganic & medicinal chemistry, 2006, Apr-15, Volume: 14, Issue:8

    Topics: Acetates; Animals; Dogs; Integrin alpha4beta1; Magnetic Resonance Spectroscopy; Male; Piperazines; Piperidines; Proline; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Fast Atom Bombardment

2006
Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
    Journal of medicinal chemistry, 2006, Feb-09, Volume: 49, Issue:3

    Topics: Animals; Binding, Competitive; CHO Cells; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Proline; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Opioid; Spiro Compounds; Stereoisomerism

2006
Mutational and bioinformatics analysis of proline- and glycine-rich motifs in vesicular acetylcholine transporter.
    Journal of neurochemistry, 2006, Volume: 98, Issue:5

    Topics: Acetylcholine; Amino Acid Motifs; Animals; Binding Sites; Biological Transport; Computational Biology; Dose-Response Relationship, Drug; Drug Interactions; Glycine; Mutation; PC12 Cells; Piperidines; Proline; Protein Binding; Rats; Sequence Alignment; Transfection; Tritium; Vesicular Acetylcholine Transport Proteins

2006
Dipeptidyl peptidase 8/9-like activity in human leukocytes.
    Journal of leukocyte biology, 2007, Volume: 81, Issue:5

    Topics: Adamantane; Antibodies, Monoclonal; Dipeptidases; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Activation; Humans; Indoles; Isoleucine; Leukocytes; Molecular Conformation; Nitriles; Organophosphonates; Piperidines; Proline; Protease Inhibitors; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship; Vildagliptin

2007
Conformational preferences of proline analogues with different ring size.
    The journal of physical chemistry. B, 2007, Apr-05, Volume: 111, Issue:13

    Topics: Azetidines; Crystallography, X-Ray; Dipeptides; Models, Molecular; Molecular Conformation; Piperidines; Proline; Thermodynamics

2007
Development of an electrolytic system for non-Kolbe electrolysis based on the acid-base reaction between carboxylic acids as a substrate and solid-supported bases.
    Journal of the American Chemical Society, 2007, May-30, Volume: 129, Issue:21

    Topics: Alanine; Carboxylic Acids; Electrolysis; Methanol; Piperidines; Proline; Silica Gel; Silicon Dioxide

2007
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
    Journal of the American Chemical Society, 2007, Sep-26, Volume: 129, Issue:38

    Topics: Boronic Acids; Carbon; Catalysis; Esters; Hydrocarbons, Aromatic; Hydroxyproline; Ketones; Models, Chemical; Piperidines; Proline; Pyrrolidines; Ruthenium; Stereoisomerism

2007
Asymmetric synthesis of bicyclic piperidines via L-proline catalyzed aldol reaction of 3-phthalimidopropanal.
    Chirality, 2008, Volume: 20, Issue:6

    Topics: Aldehydes; Bridged Bicyclo Compounds; Catalysis; Chemistry, Organic; Magnetic Resonance Spectroscopy; Molecular Structure; Phthalimides; Piperidines; Proline; Stereoisomerism

2008
Proline derived spirobarbiturates as highly effective beta-turn mimetics incorporating polar and functionalizable constraint elements.
    The Journal of organic chemistry, 2008, May-02, Volume: 73, Issue:9

    Topics: Barbiturates; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Piperidines; Proline; Spiro Compounds

2008
Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic, formal aza [3+3] cycloaddition reaction for the formation of enantioenriched piperidines.
    Angewandte Chemie (International ed. in English), 2008, Volume: 47, Issue:21

    Topics: Aldehydes; Aza Compounds; Carbamates; Catalysis; Cyclization; Ethers; Molecular Structure; Piperidines; Proline; Stereoisomerism

2008
Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid.
    The Journal of organic chemistry, 2008, Jul-04, Volume: 73, Issue:13

    Topics: Catalysis; Molecular Structure; Pipecolic Acids; Piperidines; Proline

2008
Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 2.
    Chemical biology & drug design, 2008, Volume: 72, Issue:1

    Topics: Amino Acid Substitution; Animals; Brain Chemistry; Carboxylic Acids; Inhibitory Concentration 50; Oligopeptides; Piperidines; Proline; Rats; Receptors, Opioid, mu

2008
Diversity-oriented synthesis of a drug-like system displaying the distinctive N-->C=O interaction.
    The Journal of organic chemistry, 2008, Aug-15, Volume: 73, Issue:16

    Topics: Aldehydes; Combinatorial Chemistry Techniques; Cyclization; HIV Protease; HIV-1; Hydrazines; Magnetic Resonance Spectroscopy; Molecular Conformation; Piperidines; Proline; Spectrophotometry, Ultraviolet; Stereoisomerism; Thermodynamics; Urea

2008
Mechanism of the organocatalyzed decarboxylative Knoevenagel-Doebner reaction. A theoretical study.
    The journal of physical chemistry. A, 2010, Dec-23, Volume: 114, Issue:50

    Topics: Benzaldehydes; Beverages; Carboxylic Acids; Catalysis; Food; Malonates; Models, Molecular; Molecular Conformation; Phenols; Piperidines; Proline; Quantum Theory; Solvents

2010
Biomimetic organocatalytic asymmetric synthesis of 2-substituted piperidine-type alkaloids and their analogues.
    Organic letters, 2011, Sep-02, Volume: 13, Issue:17

    Topics: Alkaloids; Biomimetics; Catalysis; Molecular Structure; Piperidines; Proline; Stereoisomerism

2011
Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
    Bioorganic & medicinal chemistry, 2011, Oct-01, Volume: 19, Issue:19

    Topics: Binding Sites; Caspase 2; Caspase 3; Caspase Inhibitors; Catalytic Domain; Cell Line; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoquinolines; Molecular Dynamics Simulation; Piperidines; Proline; Substrate Specificity

2011
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
    Science translational medicine, 2012, Jan-25, Volume: 4, Issue:118

    Topics: Animals; Dietary Proteins; Humans; Kidney; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Piperidines; Proline; Protein Deficiency; Protein Serine-Threonine Kinases; Quinazolinones; Reperfusion Injury; Stress, Physiological; Tryptophan

2012
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
    Nature, 2013, Feb-07, Volume: 494, Issue:7435

    Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Antimalarials; Binding Sites; Crystallography, X-Ray; Herbal Medicine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Medicine, Chinese Traditional; Models, Molecular; Piperidines; Proline; Quinazolines; Quinazolinones; RNA, Transfer

2013
Halofuginone suppresses T cell proliferation by blocking proline uptake and inducing cell apoptosis.
    International immunopharmacology, 2013, Volume: 16, Issue:4

    Topics: Animals; Antiprotozoal Agents; Apoptosis; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Flow Cytometry; In Situ Nick-End Labeling; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Piperidines; Proline; Quinazolinones; Receptors, Antigen, T-Cell; Spleen; T-Lymphocytes

2013
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
    Acta crystallographica. Section D, Biological crystallography, 2013, Volume: 69, Issue:Pt 10

    Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Catalytic Domain; Crystallography, X-Ray; Glutamate-tRNA Ligase; Humans; Mutagenesis; Piperidines; Proline; Protein Binding; Protein Conformation; Protein Synthesis Inhibitors; Quinazolinones; Substrate Specificity

2013
Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3-Substituted 2-(Trifluoromethyl)piperidines.
    Organic letters, 2015, Jun-19, Volume: 17, Issue:12

    Topics: Aziridines; Molecular Structure; Piperidines; Proline; Pyrrolidines; Stereoisomerism

2015
Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial Cells.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; Blotting, Western; Cell Death; Cell Proliferation; Cells, Cultured; Cyclosporine; Drug Synergism; Epithelial Cells; Flow Cytometry; Humans; Kidney Tubules; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Piperidines; Proline; Quinazolinones; Receptors, Antigen, T-Cell; Sirolimus; T-Lymphocytes

2015
Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.
    Leukemia & lymphoma, 2016, Volume: 57, Issue:11

    Topics: Adenine; Amino Acid Substitution; Female; Humans; Immunoglobulin G; Leucine; Mutation, Missense; Myeloid Differentiation Factor 88; Piperidines; Proline; Pyrazoles; Pyrimidines; Treatment Outcome; Waldenstrom Macroglobulinemia

2016
A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:5

    Topics: Alzheimer Disease; Crystallization; Nootropic Agents; Pharmaceutical Preparations; Piperidines; Proline; X-Ray Diffraction

2017
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model.
    Acta neuropathologica communications, 2018, 10-24, Volume: 6, Issue:1

    Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Animal; Ephrin-B1; Excitatory Amino Acid Agents; Glaucoma; Glial Fibrillary Acidic Protein; Intercellular Signaling Peptides and Proteins; Male; Morpholines; Phenols; Piperidines; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha

2018
Deconstructive diversification of cyclic amines.
    Nature, 2018, Volume: 564, Issue:7735

    Topics: Alkenes; Amines; Carbon; Chlorine; Cyclization; Nitrogen; Peptides; Piperidines; Proline; Pyrrolidines

2018
The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling.
    ACS infectious diseases, 2019, 04-12, Volume: 5, Issue:4

    Topics: Amino Acyl-tRNA Synthetases; Antimalarials; Drug Resistance; Eukaryotic Initiation Factor-2; Humans; Malaria, Falciparum; Phosphorylation; Piperidines; Plasmodium falciparum; Proline; Protozoan Proteins; Quinazolinones; Signal Transduction

2019
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response.
    The EMBO journal, 2022, 06-01, Volume: 41, Issue:11

    Topics: Eukaryotic Initiation Factor-2; Phosphorylation; Piperidines; Proline; Protein Biosynthesis; Quinazolinones

2022