proline has been researched along with piperidines in 64 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (14.06) | 18.7374 |
1990's | 20 (31.25) | 18.2507 |
2000's | 20 (31.25) | 29.6817 |
2010's | 14 (21.88) | 24.3611 |
2020's | 1 (1.56) | 2.80 |
Authors | Studies |
---|---|
Sen, NP; Stoltz, DR | 1 |
Hussain, T; Ravindran, B | 1 |
Hitoshi, T; Ijima, S; Iwamura, H; Kadota, T; Matsuda, A; Miyata, T; Nagata, J; Naka, M; Okano, Y; Takahama, K | 1 |
Garcia, H; Lijinsky, W | 1 |
Grant, G; Ling, N; Rivier, J; Vale, W | 1 |
Greenblatt, M; Lijinsky, W | 1 |
Flavin, M; Sharpless, NE | 1 |
Cizmárik, J; Svec, J; Svec, P | 1 |
Brechtel, C; Fleming, SR; King, SC | 1 |
Maggio, R; Nanavati, S; Vogel, Z; Wess, J | 1 |
Bilgili, SF; Hess, JB; Pinion, JL | 1 |
Abdel-Ghany, Y; Kunin, CM; LeRudulier, D; Miller, DD; Poggi, MC; Tong, HH | 1 |
Granot, I; Halevy, O; Hurwitz, S; Pines, M | 1 |
Buhr, RJ; Christensen, KD; Goodman, TN; Twining, PF; Wyatt, CL; Zimmermann, NG | 1 |
Gallard, JF; Guittet, E; Le, HT; Mayer, M; Michelot, R | 1 |
Egebjerg, J; Sørensen, PO; Thomsen, C | 1 |
Itoh, Y; Kimura, K; Oka, M; Shimidzu, T; Ukai, Y; Yoshikuni, Y | 1 |
Itoh, Y; Kimura, K; Ma, FH; Oka, M; Tatsumi, S; Ukai, Y; Yoshikuni, Y | 1 |
Aingorn, H; Condiotti, R; Genina, O; Katz, A; Miao, HQ; Nagler, A; Pines, M; Vlodavsky, I | 1 |
Ishima, T; Itoh, Y; Kimura, K; Oka, M; Shimidzu, T; Ukai, Y; Yoshikuni, Y | 1 |
Campbell, EA; Gentry, CT; Panesar, MS; Patel, S; Urban, L; Walpole, CS | 1 |
Isawa, S; Kumagai, Y; Miyatake, S; Mukai, H; Murasaki, M; Yokota, S | 1 |
Itoh, Y; Kimura, K; Kise, M; Mushiroi, T; Ogasawara, T; Tamura, M; Ukai, Y | 1 |
Ago, M; Morino, A; Mukai, H; Sugimoto, T | 1 |
Hirouchi, M; Itoh, Y; Kimura, K; Oka, M; Ukai, Y | 1 |
Ago, M; Esumi, Y; Matsuura, C; Morino, A; Mukai, H; Ogawa, Y; Seki, H; Sugimoto, T; Takaichi, M | 1 |
Falkiewicz, B | 1 |
Campbell, EA; Cruwys, S; Fox, AJ; Gentry, C; Kidd, B; Patel, S; Urban, L | 1 |
Davis, FA; Fang, T; Goswami, R | 1 |
Efange, SM; Luine, VN; Mohan, G; Tu, Z | 1 |
BUCKLEY, SD; MEISTER, A; RADHAKRISHNAN, AN | 1 |
Kinsella, BT; O'Meara, SJ | 1 |
Bojarski, AJ; Duszyńska, B; Martinez, J; Pawłowski, M; Subra, G; Zajdel, P | 1 |
Ganesh, KN; Kumar, VA | 1 |
Baldwin, JJ; Chiba, J; Hussain, Z; Machinaga, N; McDonald, E; Moriarty, KJ; Nakayama, A; Saionz, KW; Sarko, CR; Swanson, R; Takashi, T; Takayama, G; Wong, A; Yokoyama, M | 1 |
Arai-Otsuki, S; Goto, Y; Ichikawa, D; Iwasawa, Y; Ohta, H; Okamoto, O; Okuda, S; Ozaki, S; Sagara, T; Tachibana, Y; Takahashi, H | 1 |
Chandrasekaran, A; Kolmakova, NG; Ojeda, AM; Parsons, SM | 1 |
Augustyns, K; Brandt, I; Chen, X; Cheng, JD; De Meester, I; Dubois, V; Lambeir, AM; Maes, MB; Scharpé, S; Van der Veken, P | 1 |
Jhon, JS; Kang, YK | 1 |
Fuchigami, T; Kurihara, H; Tajima, T | 1 |
Gribkov, DV; Pastine, SJ; Sames, D; Schnürch, M | 1 |
Gong, Y; Peng, Y; Zhang, F | 1 |
Einsiedel, J; Gmeiner, P; Heinemann, FW; Lomlim, L; Meyer, K | 1 |
Gotoh, H; Hayashi, Y; Ishikawa, H; Masui, R | 1 |
Carlson, EC; Carter, RG; Collett, ND; Rathbone, LK; Yang, H | 1 |
Fichna, J; Gach, K; Janecka, A; Poels, J; Staniszewska, R; Toth, G; Vanden Broeck, J | 1 |
Hasserodt, J; Waibel, M | 1 |
Bermúdez, E; Saenz Méndez, P; Ventura, ON | 1 |
Bella, M; Monaco, MR; Renzi, P; Scarpino Schietroma, DM | 1 |
Brookfield, FA; Courtney, SM; Dominguez, C; Eustache, FM; Gemkow, MJ; Handel, RK; Johnson, LC; Johnson, PD; Kerry, MA; Krieger, F; Maillard, MC; Meniconi, M; Muñoz-Sanjuán, I; Palfrey, JJ; Park, H; Schaertl, S; Taylor, MG; Weddell, D | 1 |
Charlip, A; Chu, T; Gallinetti, J; Mejia, P; Mitchell, JR; Peng, W; Robertson, L; Vose, S | 1 |
Schimmel, P; Sun, L; Yang, XL; Zhou, H | 1 |
Chu, TL; Du, C; Guan, Q; Nguan, CY | 2 |
Hwang, KY; Jeon, YH; Kim, J; Kim, JH; Kim, S; Lee, EH; Park, M; Son, J | 1 |
Antoun, Z; Bidault, R; Cossy, J; Gomez Pardo, D; Orliac, A; Rioton, S | 1 |
Castillo, JJ; Ghobrial, IM; Treon, SP | 1 |
Harmsen, B; Leyssens, T; Robeyns, K; Wouters, J | 1 |
Gao, F; Li, F; Li, XY; Liu, ST; Miao, Y; Sun, XH; Wang, X; Wang, Z; Yang, XL; Zhang, ML; Zhong, SM; Zhu, K | 1 |
Göttemann, LT; Kuroda, Y; Roque, JB; Sarpong, R | 1 |
Bopp, SE; Clish, CB; Deik, AA; Fagbami, L; Herman, JD; Lukens, AK; Mazitschek, R; Santos, SA; Singh, K; Wirth, DF | 1 |
Bertolotti, A; Peak-Chew, SY; Pitera, AP; Szaruga, M; Wingett, SW | 1 |
1 trial(s) available for proline and piperidines
Article | Year |
---|---|
Comparison of pharmacokinetics of NS-105, a novel agent for cerebrovascular disease, in elderly and young subjects.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Area Under Curve; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Humans; Kidney; Least-Squares Analysis; Linear Models; Male; Metabolic Clearance Rate; Nootropic Agents; Piperidines; Proline | 1999 |
63 other study(ies) available for proline and piperidines
Article | Year |
---|---|
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: some N-nitroso compounds.
Topics: Animals; Butylamines; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Ethanolamines; Ethylamines; Ethylnitrosourea; Folic Acid; Humans; Methylamines; Methylnitrosourea; Morpholines; Nicotine; Nitrosamines; Nitroso Compounds; Piperidines; Proline; Propylamines; Research Design; Sarcosine; Streptozocin | 1978 |
Mutagenicity of five cyclic N-nitrosamines: assay with Salmonella typhimurium.
Topics: Hydroxyproline; In Vitro Techniques; Microsomes, Liver; Mutagens; Nitrosamines; Piperidines; Proline; Pyrrolidines; Salmonella typhimurium; Structure-Activity Relationship | 1977 |
Antigenic mimicry between piperazine derivatives and Wuchereria bancrofti microfilariae.
Topics: Animals; Antibodies, Helminth; Cross Reactions; Diethylcarbamazine; Enzyme-Linked Immunosorbent Assay; Haptens; Microfilariae; Nipecotic Acids; Piperazines; Piperidines; Proline; Wuchereria bancrofti | 1992 |
Imino acid and related alicyclic amine levels in biological fluids.
Topics: Amines; Animals; Body Fluids; Female; Gas Chromatography-Mass Spectrometry; Humans; Imino Acids; Male; Pipecolic Acids; Piperidines; Proline; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains | 1985 |
Studies of the tumorigenic effect in feeding of nitrosamino acids and of low doses of amines and nitrite to rats.
Topics: Animals; Carcinogens; Hydroxyproline; Imines; Morpholines; Nitrites; Nitroso Compounds; Pipecolic Acids; Piperazines; Piperidines; Proline; Pyrrolidines; Rats; Water | 1973 |
Orientation restrictions of the peptide hormone, thyrotropin-releasing factor, due to intramolecular hydrogen bonding.
Topics: Alkylation; Glutamates; Histidine; Hydrogen-Ion Concentration; Imidazoles; Methylation; Models, Chemical; Piperidines; Potentiometry; Proline; Pyrrolidines; Structure-Activity Relationship; Thyrotropin-Releasing Hormone | 1972 |
Failure to induce tumors in Swiss mice after concurrent administration of amino acids and sodium nitrite.
Topics: Adenoma; Animals; Arginine; Carcinogens; Female; Hydroxyproline; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrites; Nitroso Compounds; Piperidines; Proline; Pyrrolidines | 1972 |
The reactions of amines and amino acids with maleimides. Structure of the reaction products deduced from infrared and nuclear magnetic resonance spectroscopy.
Topics: Amides; Amines; Chemical Phenomena; Chemistry, Physical; Ethylmaleimide; Imides; Infrared Rays; Magnetic Resonance Spectroscopy; Piperidines; Proline; Pyrrolidines; Spectrum Analysis | 1966 |
In vitro cytotoxicity in rabbit corneal cells of two new local anesthetics--pentacaine and heptacaine.
Topics: Anesthetics, Local; Animals; Carbamates; Cornea; In Vitro Techniques; Piperidines; Proline; Rabbits; Thymidine; Trimecaine | 1981 |
Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP.
Topics: Biological Transport; Escherichia coli; Escherichia coli Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Genes, Bacterial; Membrane Transport Modulators; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Substrate Specificity | 1995 |
Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Carbachol; Cell Line; Codon; GTP-Binding Proteins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Parasympatholytics; Piperidines; Proline; Protein Conformation; Rats; Receptors, Muscarinic; Recombinant Proteins; Restriction Mapping; RNA; Scopolamine Derivatives; Transfection; Tryptophan | 1993 |
The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of female broilers: influence of a high-proline diet supplemented with ascorbic acid and zinc.
Topics: Animals; Ascorbic Acid; Body Weight; Chickens; Coccidiostats; Female; Food, Fortified; Piperidines; Proline; Pyrans; Quinazolines; Quinazolinones; Skin; Skin Physiological Phenomena; Tensile Strength; Zinc | 1995 |
Effect of novel compound, 1-methyl-1-piperidino methane sulfonate (MPMS), on the osmoprotectant activity of glycine betaine, choline and L-proline in Escherichia coli.
Topics: Azetidinecarboxylic Acid; Betaine; Biological Transport; Choline; Escherichia coli; Mesylates; Piperidines; Proline; Sodium Chloride; Water-Electrolyte Balance | 1993 |
Halofuginone: an inhibitor of collagen type I synthesis.
Topics: Animals; Birds; Cell Division; Cells, Cultured; Coccidiostats; Collagen; Embryo, Mammalian; Embryo, Nonmammalian; Fibroblasts; Gene Expression; Growth Plate; Matrix Metalloproteinase Inhibitors; Mice; Piperidines; Proline; Quinazolines; Quinazolinones; Rats; Species Specificity | 1993 |
Mitigating the effects of halofuginone on skin strength by feeding L-proline to broiler chickens.
Topics: Animals; Body Weight; Chickens; Coccidiostats; Collagen; Female; Food, Fortified; Male; Piperidines; Proline; Quinazolines; Quinazolinones; Skin; Skin Physiological Phenomena; Tensile Strength | 1995 |
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.
Topics: Amino Acids; Cross-Linking Reagents; Imines; Leucine; Models, Chemical; Organophosphorus Compounds; Oxazoles; Phosphorus; Piperidines; Proline; Sulfhydryl Compounds; Thioamides | 1996 |
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
Topics: Animals; Carrier Proteins; Cell Line; Cricetinae; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Tiagabine | 1997 |
Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine | 1997 |
A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cells, Cultured; Cerebral Cortex; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Mice; Neurons; Pertussis Toxin; Piperidines; Proline; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1997 |
Inhibition of glomerular mesangial cell proliferation and extracellular matrix deposition by halofuginone.
Topics: Animals; Carbon Radioisotopes; Cell Division; Cells, Cultured; Collagen; Extracellular Matrix; Gene Expression; Glomerular Mesangium; Piperidines; Proline; Protein Synthesis Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Sulfates; Tritium | 1997 |
Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depressive Disorder; Male; Microdialysis; Norepinephrine; Piperidines; Proline; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, GABA-B; Receptors, Serotonin; Serotonin; Synaptosomes | 1997 |
Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Naphthalenes; Nerve Fibers; Neuralgia; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Proline; Receptors, Neurokinin-1; Spinal Cord | 1998 |
Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.
Topics: Acetylcholine; Animals; Avoidance Learning; Basal Ganglia; Cerebral Cortex; Cognition; Electroshock; gamma-Aminobutyric Acid; Male; Memory Disorders; Muscarinic Antagonists; Nootropic Agents; Parasympathetic Nervous System; Piperidines; Proline; Rats; Rats, Wistar; Receptors, GABA-B; Scopolamine; Synaptosomes | 1999 |
Pharmacokinetics of NS-105, a novel cognition enhancer. 1st communication: absorption, metabolism and excretion in rats, dogs and monkeys after single administration of 14C-NS-105.
Topics: Administration, Oral; Animals; Bile; Biotransformation; Blood Proteins; Dogs; Feces; Female; Food-Drug Interactions; Injections, Intravenous; Intestinal Absorption; Lymph; Macaca fascicularis; Male; Nootropic Agents; Piperidines; Proline; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1999 |
Role of metabotropic glutamate receptor subclasses in modulation of adenylyl cyclase activity by a nootropic NS-105.
Topics: Adenylyl Cyclases; Animals; Benzoates; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation; Glycine; Male; Membranes; Neurons; Nootropic Agents; Oligodeoxyribonucleotides, Antisense; Oligonucleotides; Piperidines; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger | 2000 |
Pharmacokinetics of NS-105, a novel cognition enhancer. 2nd communication: distribution and transfer into fetus and milk after single administration, and effects of repeated administration on pharmacokinetics and hepatic drug-metabolizing enzyme activitie
Topics: Animals; Feces; Female; Fetus; Intestinal Absorption; Liver; Male; Maternal-Fetal Exchange; Milk; Nootropic Agents; Piperidines; Placenta; Pregnancy; Proline; Rats; Rats, Sprague-Dawley; Sex Characteristics; Tissue Distribution | 1999 |
Comparison of the efficiency of various coupling systems in the acylation of model secondary amines with thymin-1-ylacetic acid.
Topics: Acetates; Acylation; Amines; Carbodiimides; Hydrocarbons, Brominated; Indicators and Reagents; Peptide Nucleic Acids; Piperidines; Proline; Thymine | 1999 |
Fasoracetam. LAM 105, NS 105.
Topics: Animals; Clinical Trials as Topic; Cognition Disorders; Humans; Nootropic Agents; Piperidines; Proline; Rats; Rats, Wistar | 1999 |
Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Female; Freund's Adjuvant; Guinea Pigs; Humans; Hyperalgesia; Indoles; Isoindoles; Male; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Proline; Quinuclidines | 2000 |
Asymmetric synthesis of substituted prolines from delta-amino beta-ketoesters. Methyl (2S,5R)-(+)-5-phenylpyrrolidine-2-carboxylate.
Topics: Cholecystokinin; Indicators and Reagents; Keto Acids; Piperidines; Proline; Stereoisomerism | 2002 |
Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.
Topics: Animals; Benzopyrans; Cholinesterase Inhibitors; Donepezil; Female; Indans; Memory; Nicotinic Agonists; Ovariectomy; Piperidines; Proline; Rats; Rats, Sprague-Dawley; Space Perception; Stimulation, Chemical; Visual Perception | 2002 |
Enzymatic synthesis of L-pipecolic acid and L-proline.
Topics: Pipecolic Acids; Piperidines; Proline | 1957 |
The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
Topics: Adrenergic beta-Agonists; Alkyl and Aryl Transferases; Amino Acid Motifs; Animals; Calcium Signaling; Carrier Proteins; Cell Line; Cell Line, Tumor; Cyclic AMP; Dose-Response Relationship, Drug; Endocytosis; Epoprostenol; Farnesyltranstransferase; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; Humans; Iloprost; Isoproterenol; Kidney; Leukemia, Erythroblastic, Acute; Mice; Mutagenesis, Site-Directed; Organophosphorus Compounds; Piperidines; Proline; Propanolamines; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Pyridines; Receptors, Adrenergic, beta-2; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2005 |
Parallel solid-phase synthesis and characterization of new sulfonamide and carboxamide proline derivatives as potential CNS agents.
Topics: Amides; Binding, Competitive; Central Nervous System Agents; Ligands; Molecular Structure; Piperidines; Proline; Pyrrolidines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Receptors, Serotonin; Sulfonamides; Tosyl Compounds | 2005 |
Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity.
Topics: Amino Acid Sequence; Directed Molecular Evolution; DNA; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Nucleic Acids; Piperidines; Proline; Pyrrolidines; RNA; Substrate Specificity | 2005 |
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Topics: Acetates; Animals; Dogs; Integrin alpha4beta1; Magnetic Resonance Spectroscopy; Male; Piperazines; Piperidines; Proline; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Fast Atom Bombardment | 2006 |
Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
Topics: Animals; Binding, Competitive; CHO Cells; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Proline; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, Opioid; Spiro Compounds; Stereoisomerism | 2006 |
Mutational and bioinformatics analysis of proline- and glycine-rich motifs in vesicular acetylcholine transporter.
Topics: Acetylcholine; Amino Acid Motifs; Animals; Binding Sites; Biological Transport; Computational Biology; Dose-Response Relationship, Drug; Drug Interactions; Glycine; Mutation; PC12 Cells; Piperidines; Proline; Protein Binding; Rats; Sequence Alignment; Transfection; Tritium; Vesicular Acetylcholine Transport Proteins | 2006 |
Dipeptidyl peptidase 8/9-like activity in human leukocytes.
Topics: Adamantane; Antibodies, Monoclonal; Dipeptidases; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Activation; Humans; Indoles; Isoleucine; Leukocytes; Molecular Conformation; Nitriles; Organophosphonates; Piperidines; Proline; Protease Inhibitors; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship; Vildagliptin | 2007 |
Conformational preferences of proline analogues with different ring size.
Topics: Azetidines; Crystallography, X-Ray; Dipeptides; Models, Molecular; Molecular Conformation; Piperidines; Proline; Thermodynamics | 2007 |
Development of an electrolytic system for non-Kolbe electrolysis based on the acid-base reaction between carboxylic acids as a substrate and solid-supported bases.
Topics: Alanine; Carboxylic Acids; Electrolysis; Methanol; Piperidines; Proline; Silica Gel; Silicon Dioxide | 2007 |
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
Topics: Boronic Acids; Carbon; Catalysis; Esters; Hydrocarbons, Aromatic; Hydroxyproline; Ketones; Models, Chemical; Piperidines; Proline; Pyrrolidines; Ruthenium; Stereoisomerism | 2007 |
Asymmetric synthesis of bicyclic piperidines via L-proline catalyzed aldol reaction of 3-phthalimidopropanal.
Topics: Aldehydes; Bridged Bicyclo Compounds; Catalysis; Chemistry, Organic; Magnetic Resonance Spectroscopy; Molecular Structure; Phthalimides; Piperidines; Proline; Stereoisomerism | 2008 |
Proline derived spirobarbiturates as highly effective beta-turn mimetics incorporating polar and functionalizable constraint elements.
Topics: Barbiturates; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Piperidines; Proline; Spiro Compounds | 2008 |
Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic, formal aza [3+3] cycloaddition reaction for the formation of enantioenriched piperidines.
Topics: Aldehydes; Aza Compounds; Carbamates; Catalysis; Cyclization; Ethers; Molecular Structure; Piperidines; Proline; Stereoisomerism | 2008 |
Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid.
Topics: Catalysis; Molecular Structure; Pipecolic Acids; Piperidines; Proline | 2008 |
Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 2.
Topics: Amino Acid Substitution; Animals; Brain Chemistry; Carboxylic Acids; Inhibitory Concentration 50; Oligopeptides; Piperidines; Proline; Rats; Receptors, Opioid, mu | 2008 |
Diversity-oriented synthesis of a drug-like system displaying the distinctive N-->C=O interaction.
Topics: Aldehydes; Combinatorial Chemistry Techniques; Cyclization; HIV Protease; HIV-1; Hydrazines; Magnetic Resonance Spectroscopy; Molecular Conformation; Piperidines; Proline; Spectrophotometry, Ultraviolet; Stereoisomerism; Thermodynamics; Urea | 2008 |
Mechanism of the organocatalyzed decarboxylative Knoevenagel-Doebner reaction. A theoretical study.
Topics: Benzaldehydes; Beverages; Carboxylic Acids; Catalysis; Food; Malonates; Models, Molecular; Molecular Conformation; Phenols; Piperidines; Proline; Quantum Theory; Solvents | 2010 |
Biomimetic organocatalytic asymmetric synthesis of 2-substituted piperidine-type alkaloids and their analogues.
Topics: Alkaloids; Biomimetics; Catalysis; Molecular Structure; Piperidines; Proline; Stereoisomerism | 2011 |
Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
Topics: Binding Sites; Caspase 2; Caspase 3; Caspase Inhibitors; Catalytic Domain; Cell Line; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoquinolines; Molecular Dynamics Simulation; Piperidines; Proline; Substrate Specificity | 2011 |
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
Topics: Animals; Dietary Proteins; Humans; Kidney; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Piperidines; Proline; Protein Deficiency; Protein Serine-Threonine Kinases; Quinazolinones; Reperfusion Injury; Stress, Physiological; Tryptophan | 2012 |
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Antimalarials; Binding Sites; Crystallography, X-Ray; Herbal Medicine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Medicine, Chinese Traditional; Models, Molecular; Piperidines; Proline; Quinazolines; Quinazolinones; RNA, Transfer | 2013 |
Halofuginone suppresses T cell proliferation by blocking proline uptake and inducing cell apoptosis.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Flow Cytometry; In Situ Nick-End Labeling; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Piperidines; Proline; Quinazolinones; Receptors, Antigen, T-Cell; Spleen; T-Lymphocytes | 2013 |
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Catalytic Domain; Crystallography, X-Ray; Glutamate-tRNA Ligase; Humans; Mutagenesis; Piperidines; Proline; Protein Binding; Protein Conformation; Protein Synthesis Inhibitors; Quinazolinones; Substrate Specificity | 2013 |
Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3-Substituted 2-(Trifluoromethyl)piperidines.
Topics: Aziridines; Molecular Structure; Piperidines; Proline; Pyrrolidines; Stereoisomerism | 2015 |
Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial Cells.
Topics: Animals; Blotting, Western; Cell Death; Cell Proliferation; Cells, Cultured; Cyclosporine; Drug Synergism; Epithelial Cells; Flow Cytometry; Humans; Kidney Tubules; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Piperidines; Proline; Quinazolinones; Receptors, Antigen, T-Cell; Sirolimus; T-Lymphocytes | 2015 |
Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.
Topics: Adenine; Amino Acid Substitution; Female; Humans; Immunoglobulin G; Leucine; Mutation, Missense; Myeloid Differentiation Factor 88; Piperidines; Proline; Pyrazoles; Pyrimidines; Treatment Outcome; Waldenstrom Macroglobulinemia | 2016 |
A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical.
Topics: Alzheimer Disease; Crystallization; Nootropic Agents; Pharmaceutical Preparations; Piperidines; Proline; X-Ray Diffraction | 2017 |
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Animal; Ephrin-B1; Excitatory Amino Acid Agents; Glaucoma; Glial Fibrillary Acidic Protein; Intercellular Signaling Peptides and Proteins; Male; Morpholines; Phenols; Piperidines; Proline; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha | 2018 |
Deconstructive diversification of cyclic amines.
Topics: Alkenes; Amines; Carbon; Chlorine; Cyclization; Nitrogen; Peptides; Piperidines; Proline; Pyrrolidines | 2018 |
The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling.
Topics: Amino Acyl-tRNA Synthetases; Antimalarials; Drug Resistance; Eukaryotic Initiation Factor-2; Humans; Malaria, Falciparum; Phosphorylation; Piperidines; Plasmodium falciparum; Proline; Protozoan Proteins; Quinazolinones; Signal Transduction | 2019 |
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response.
Topics: Eukaryotic Initiation Factor-2; Phosphorylation; Piperidines; Proline; Protein Biosynthesis; Quinazolinones | 2022 |