proline has been researched along with mk-7009 in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 27 (93.10) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, MD; Breidinger, SA; Woolf, EJ | 1 |
| Carroll, SS; Dimuzio, J; Fandozzi, C; Graham, DJ; Hazuda, D; Holloway, MK; Liverton, NJ; Ludmerer, SW; McCauley, JA; McIntyre, CJ; Olsen, DB; Rudd, MT; Stahlhut, M; Vacca, JP | 1 |
| Di Francesco, ME; Koch, U; Pace, P; Pesci, S; Pompei, M; Summa, V; Veneziano, M; Vignetti, SE | 1 |
| Bush, KJ; Butcher, JW; Carroll, SS; DiMuzio, JM; Fandozzi, CM; Gilbert, KF; Graham, DJ; Holloway, MK; Liverton, NJ; Ludmerer, SW; Mao, SS; McCauley, JA; McIntyre, CJ; Nguyen, KT; Olsen, DB; Romano, JJ; Rudd, MT; Stahlhut, MW; Swestock, J; Trainor, N; Vacca, JP; Wan, BL | 1 |
| Bae, A; Chen, X; Harris, J; Ku, K; Miller, MD; Mo, H; Qi, X; Sun, SC; Wong, KA; Worth, A | 1 |
| Carroll, SS; Davies, ME; Graham, D; Handt, L; Hazuda, D; Koeplinger, K; Liverton, N; Ludmerer, SW; MacCoss, M; Olsen, DB; Zhang, NR | 1 |
| Bukh, J; Ghanem, L; Gottwein, JM; Jensen, TB; Scheel, TK | 1 |
| Khungar, V; Poordad, F | 1 |
| Belyk, KM; Davies, IW; Devine, PN; Dormer, PG; Humphrey, G; Journet, M; Kuethe, JT; Lieberman, D; Nolting, A; Peng, Z; Reamer, RA; Song, ZJ; Tellers, DM; Tschaen, DM; Waters, MS; Zewge, D; Zhang, F; Zhao, D | 1 |
| Balsells-Padros, J; Cao, Y; Chen, CY; Dolman, SJ; Dunn, RF; Janey, J; Kong, J; Li, H; Zacuto, MJ | 1 |
| Barnard, RJ; Caro, L; Gane, E; Hwang, PM; Lee, AW; Manns, MP; Marcellin, P; Rodriguez-Torres, M; Stoehr, A; Wiedmann, RT; Yeh, CT | 1 |
| Ali, A; Aydin, C; Cao, H; Deveau, LM; Huang, W; Newton, A; Ozen, A; Petropoulos, CJ; Romano, KP; Schiffer, CA; Silver, C; Soumana, D | 1 |
| An, D; Barnard, RJ; Bhanja, S; Gane, EJ; Gress, J; Hwang, P; Lawitz, E; Mobashery, N; Rodriguez-Torres, M; Serfaty, L; Stoehr, A | 1 |
| Ban, Y; Liu, H; Xue, W; Yao, X | 1 |
| Al-Ibrahim, M; Barnard, R; Caro, L; Gordon, SC; Gress, J; Hwang, PM; Jacobson, I; Kraft, WK; Kwo, P; Lawitz, E; Maliakkal, B; Miller, M; Mobashery, N; Panorchan, P; Quirk, E; Rockstroh, JK; Sulkowski, M | 1 |
| Barnard, RJ; Cheney, CA; Dinubile, MJ; Graham, DJ; Hazuda, DJ; Himmelberger, AL; Hwang, PM; McHale, CM; Mobashery, N; Newhard, W; Nickle, D; Reeves, JD; Rivera, AA; Strizki, J | 1 |
| Barnard, RJ; Bhanja, S; Bourque, M; DiNubile, MJ; Gane, EJ; Hwang, PM; Lawitz, E; Mobashery, N; Rodriguez-Torres, M; Serfaty, L; Stoehr, A; Strizki, J; Zhou, A | 1 |
| Furusyo, N; Hayashi, J; Hiramine, S; Mitsumoto, F; Murata, M; Ogawa, E; Shimizu, M; Takayama, K; Toyoda, K; Ura, K | 1 |
| Hayashi, N; Izumi, N; Mobashery, N | 1 |
| Anderson, M; Caro, L; Cerra, M; Du, L; Manns, MP; Nachbar, RB; Panorchan, P; Potthoff, A; Talal, AH; Wagner, J; Wright, DH | 1 |
| Iwasa, T; Kinoshita, K; Nakamura, K; Takase, A | 1 |
| Hayashi, N; Howe, AY; Kumada, H; Ludmerer, SW; Mobashery, N; Nakamuta, M; Takase, A; Takehara, T | 1 |
| Abe, H; Aikata, H; Chayama, K; Ellis, JD; Hayes, CN; Hiraga, N; Imamura, M; Ishida, Y; Kan, H; Miyaki, E; Tateno, C; Tsuge, M; Uchida, T; Yoshimi, S | 1 |
| Takehara, T | 1 |
| Chayama, K; Fujimoto, G; Howe, AY; Karino, Y; Kumada, H; Ludmerer, SW; Mobashery, N; Mochida, S; Nakamura, K; Suzuki, F | 1 |
| Black, S; Chang, W; Hayashi, N; Hirano, T; Howe, AY; Kumada, H; Ludmerer, SW; Nakamura, K; Nickle, D; Takase, A; Tanaka, Y | 1 |
| Imaizumi, N; Kashiwagi, T; Kashiwamura, S; Kishida, Y; Tanimura, H | 1 |
| Bédard, AC; Collins, SK; Godin, É; Raymond, M | 1 |
| Anderson, M; Caro, L; Chung, C; Fandozzi, C; Fraser, I; Gao, W; Howell, B; Mangin, E; Maxwell, J; Miltenburg, AMM; Popa, S; Railkar, R; Shire, NJ; Stoch, SA; Talal, AH; Van Dyck, K; Webber, AL; Wenning, L | 1 |
2 review(s) available for proline and mk-7009
| Article | Year |
|---|---|
Emerging therapeutic options in hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication | 2011 |
[Preclinical and clinical properties of vaniprevir (VANIHEP® Capsules 150 mg), a novel therapeutic agent for hepatitis C].
Topics: Antiviral Agents; Capsules; Clinical Trials as Topic; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Sulfonamides | 2015 |
12 trial(s) available for proline and mk-7009
| Article | Year |
|---|---|
Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: a randomized phase II study.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Sulfonamides; Young Adult | 2012 |
A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Young Adult | 2013 |
Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: safety, antiviral activity, resistance, and pharmacokinetics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Carrier Proteins; Cyclopropanes; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Protease Inhibitors; Sulfonamides; Viral Nonstructural Proteins; Young Adult | 2013 |
Emergence of resistance-associated variants after failed triple therapy with vaniprevir in treatment-experienced non-cirrhotic patients with hepatitis C-genotype 1 infection: a population and clonal analysis.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Peptide Hydrolases; Polyethylene Glycols; Proline; Ribavirin; RNA, Viral; Sulfonamides; Treatment Failure; Treatment Outcome; Viremia; Young Adult | 2013 |
Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis.
Topics: Adolescent; Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Placebos; Proline; Ribavirin; Sulfonamides; Treatment Outcome; Viral Load; Young Adult | 2014 |
Vaniprevir plus peginterferon alfa-2a and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase II study.
Topics: Adult; Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Sulfonamides; Viral Load; Young Adult | 2015 |
Liver-to-plasma vaniprevir (MK-7009) concentration ratios in HCV-infected patients.
Topics: Administration, Oral; Adult; Aged; Antiviral Agents; Biopsy; Cyclopropanes; Drug Monitoring; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Liver Cirrhosis; Male; Middle Aged; Proline; Sulfonamides | 2015 |
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Sulfonamides; Treatment Outcome; Young Adult | 2016 |
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 (GT1b) infection: Phase 3 studies.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; RNA, Viral; Sulfonamides; Viral Load; Young Adult | 2016 |
HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials.
Topics: Amino Acid Substitution; Antiviral Agents; Codon; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Evolution, Molecular; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mutation; Phylogeny; Proline; Sequence Analysis, DNA; Sulfonamides; Treatment Failure; Treatment Outcome | 2016 |
A Protease Inhibitor with Induction Therapy with Natural Interferon-β in Patients with HCV Genotype 1b Infection.
Topics: Aged; Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-beta; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Simeprevir; Sulfonamides | 2016 |
Fine-Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection.
Topics: Adult; Antiviral Agents; Biopsy, Fine-Needle; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Male; Middle Aged; Proline; Sulfonamides; Tissue Distribution; Young Adult | 2020 |
15 other study(ies) available for proline and mk-7009
| Article | Year |
|---|---|
Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid chromatography with tandem mass spectrometric detection.
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Cyclopropanes; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Polysorbates; Proline; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Surface-Active Agents; Tandem Mass Spectrometry; Viral Nonstructural Proteins | 2009 |
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Topics: Animals; Antiviral Agents; Area Under Curve; Cell Line; Cyclopropanes; Dogs; Genotype; Half-Life; Hepacivirus; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Macaca mulatta; Pan troglodytes; Proline; Protease Inhibitors; Rats; Recombinant Proteins; Replicon; Substrate Specificity; Sulfonamides; Viral Nonstructural Proteins | 2010 |
Novel P2-P4 macrocyclic inhibitors of HCV NS3/4A protease by P3 succinamide fragment depeptidization strategy.
Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Binding Sites; Cell Line; Computer Simulation; Cyclopropanes; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Rats; Rats, Wistar; Succinates; Sulfonamides; Viral Nonstructural Proteins | 2010 |
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
Topics: Animals; Area Under Curve; Carrier Proteins; Cyclopropanes; Dogs; Drug Discovery; Drug Evaluation, Preclinical; Hepacivirus; Indoles; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Macaca mulatta; Macrocyclic Compounds; Metabolic Clearance Rate; Models, Chemical; Molecular Structure; Pan troglodytes; Proline; Rats; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins; Viral Proteins | 2010 |
Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors.
Topics: Antiviral Agents; Cell Line, Tumor; Cyclopropanes; Hepacivirus; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Molecular Structure; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Sulfonamides | 2010 |
Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
Topics: Animals; Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Pan troglodytes; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Tubercidin; Viral Load; Viral Nonstructural Proteins | 2011 |
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Molecular Sequence Data; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins | 2011 |
Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.
Topics: Catalysis; Chemistry Techniques, Synthetic; Cyclization; Cyclopropanes; Hydrogenation; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Palladium; Proline; Sulfonamides | 2011 |
Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.
Topics: Catalysis; Cyclization; Cyclopropanes; Hepacivirus; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Molecular Structure; Proline; Protease Inhibitors; Ruthenium; Sulfonamides | 2012 |
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Topics: Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins | 2012 |
Computational study on the drug resistance mechanism against HCV NS3/4A protease inhibitors vaniprevir and MK-5172 by the combination use of molecular dynamics simulation, residue interaction network, and substrate envelope analysis.
Topics: Amides; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Protease Inhibitors; Protein Conformation; Quinoxalines; Sulfonamides; Thermodynamics; Viral Nonstructural Proteins | 2014 |
A case of successful treatment with telaprevir-based triple therapy for hepatitis C infection after treatment failure with vaniprevir-based triple therapy.
Topics: Aged; Antiviral Agents; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Oligopeptides; Proline; Sulfonamides; Treatment Failure | 2014 |
Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.
Topics: Animals; Antiviral Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Gene Expression Profiling; Hepacivirus; Hepatitis C; Hepatocytes; High-Throughput Nucleotide Sequencing; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mice; Mice, Transgenic; Mutation, Missense; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Virus Replication | 2016 |
[Vaniprevir with pegylated interferon and ribavirin in treatment for chronic hepatitis C].
Topics: Clinical Trials as Topic; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Indoles; Interferons; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Ribavirin; Sulfonamides | 2015 |
Phase Separation Macrocyclization in a Complex Pharmaceutical Setting: Application toward the Synthesis of Vaniprevir.
Topics: Alkynes; Cyclization; Cyclopropanes; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Macromolecular Substances; Microwaves; Molecular Structure; Proline; Sulfonamides | 2017 |