proline and methotrexate

proline has been researched along with methotrexate in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's1 (8.33)18.2507
2000's5 (41.67)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Roberts, WK; Talmage, DW; Thomas, DW1
Frank, N; Osswald, H1
Chojkier, M; Laine, L1
Fukui, K; Halprin, K; Marks, R1
Gerron, GG; Howard, CH; Rudman, D; Vogler, WR1
Auerbach, G; Bader, G; Dams, T; Huber, R; Jacob, U; Jaenicke, R; Ploom, T1
Cole, SP; Conseil, G; Deeley, RG; Koike, K; Leslie, EM1
Barnes, NC; Bradford, TM; Cambier, JC; Hogarth, PM; Musgrave, IF; Powell, MS; Wines, BD1
Cole, SP; Deeley, RG; Létourneau, IJ; Slot, AJ1
Cole, SP; Deeley, RG; Létourneau, IJ; Nakajima, A1
Patel, N; Shah, A; Wu, Z; Yuan, X1
Stephenson, A; Wu, Z; Yuan, X1

Other Studies

12 other study(ies) available for proline and methotrexate

ArticleYear
Antibody synthesis in synchronized mouse spleen cells during the secondary response to sheep erythrocytes in vitro.
    Journal of immunology (Baltimore, Md. : 1950), 1975, Volume: 114, Issue:1 Pt 2

    Topics: Adenosine; Animals; Antibody Formation; Antigens; Cells, Cultured; Colchicine; Dactinomycin; Erythrocytes; Immunologic Memory; Lymphocyte Activation; Lymphocytes; Methotrexate; Mice; Mitosis; Proline; Protein Hydrolysates; Sheep; Spleen; Tritium

1975
Sacrosine- and prolinedithiocarbamate pretreatment increases the therapeutic efficacy of doxorubicin, methotrexate, teniposide, mitoxantrone or cyclohexylchloroethylnitrosourea in leukemia L1210.
    Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:5

    Topics: Animals; Antineoplastic Agents; Cysteine; Doxorubicin; Drug Synergism; Female; Leukemia L1210; Lomustine; Methotrexate; Mice; Mice, Inbred DBA; Mitoxantrone; Proline; Sarcosine; Teniposide; Thiocarbamates

1990
Hepatic collagen production in the rat is unaffected by methotrexate.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 182, Issue:2

    Topics: Animals; Collagen; Liver; Methotrexate; Proline; Rats; Triglycerides

1986
The application of an in vitro technique to the study of epidermal replication and metabolism.
    The British journal of dermatology, 1971, Volume: 84, Issue:5

    Topics: Culture Techniques; DNA; Folic Acid Antagonists; Growth Inhibitors; Histidine; Humans; Methods; Methotrexate; Nucleosides; Proline; Protein Biosynthesis; Psoriasis; RNA; Skin; Thymidine; Tritium

1971
Observations on the plasma amino acids of patients with acute leukemia.
    Cancer research, 1971, Volume: 31, Issue:8

    Topics: Acute Disease; Alanine; Amino Acids; Asparaginase; Cytarabine; Glucocorticoids; Glutamine; Histidine; Humans; Indicators and Reagents; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methionine; Methotrexate; Nitrogen; Proline; Threonine; Vincristine

1971
The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
    Journal of molecular biology, 2000, Mar-31, Volume: 297, Issue:3

    Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Dimerization; Enzyme Stability; Folic Acid Antagonists; Ligands; Methotrexate; Models, Molecular; Molecular Sequence Data; NADP; Proline; Protein Structure, Quaternary; Protein Structure, Secondary; Sequence Alignment; Solubility; Static Electricity; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thermotoga maritima

2000
Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Anions; Biological Transport; Blotting, Northern; Cell Line; Cell Membrane; Cytoplasm; Dose-Response Relationship, Drug; Genetic Vectors; Humans; Kidney; Kinetics; Methotrexate; Microscopy, Confocal; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation; Nucleotides; Proline; Protein Binding; Protein Transport; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Substrate Specificity; Transfection; Vanadates

2004
Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Jun-15, Volume: 176, Issue:12

    Topics: Animals; Antigens, CD; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Dimerization; Down-Regulation; Humans; Immunoglobulin G; Ligands; Methotrexate; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Proline; Receptors, IgG; Serine; Signal Transduction; Tetrahydrofolate Dehydrogenase

2006
Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8

    Topics: Adenosine Triphosphate; Azides; Binding Sites; Cations, Divalent; Cell Line; Cell Membrane; Estradiol; Humans; Leukotriene C4; Membrane Transport Proteins; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation, Missense; Photochemistry; Proline; Protein Binding; Transfection; Vanadates

2007
Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.
    Biochemical pharmacology, 2008, Apr-15, Volume: 75, Issue:8

    Topics: Cell Line; Estradiol; Humans; Leukotriene C4; Methotrexate; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Proline; Protein Structure, Tertiary; Transfection; Transport Vesicles; Trypsin

2008
Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells.
    Bioorganic & medicinal chemistry letters, 2010, Sep-01, Volume: 20, Issue:17

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Methotrexate; Prodrugs; Proline

2010
The preformulation stability studies of a proline prodrug of methotrexate.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:4

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Methotrexate; Molecular Structure; Prodrugs; Proline

2012