Compounds > proline

proline and melphalan

proline has been researched along with melphalan in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bielawska, A; Bielawski, K; Chrzanowski, K; Pałka, J; Wołczyński, S1
Chrzanowski, K; Pałka, J1
Bielawska, A; Chrzanowski, K; Pałka, J1
Alessi, P; Heinis, C; Neri, D1
Amidon, GL; Mittal, S; Song, X; Vig, BS1
Amidon, GL; Hilfinger, JM; Landowski, CP; Lee, KD; Mittal, S; Tsume, Y1
Cho, DH; Hur, DY; Kim, D; Kim, S; Kim, YS; Lee, HK; Lee, WJ; Park, GB1
Amidon, GL; Dahan, A; Landowski, CP; Mittal, S; Wolk, O; Wu, Z; Yang, P1

Other Studies

8 other study(ies) available for proline and melphalan

ArticleYear
Cytotoxicity and effect on collagen biosynthesis of proline analogue of melphalan as a prolidase-convertible prodrug in cultured human skin fibroblasts.
    Farmaco (Societa chimica italiana : 1989), 2001, Volume: 56, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Cell Survival; Cells, Cultured; Child; Collagen; Dipeptidases; Fibroblasts; Humans; Male; Melphalan; Prodrugs; Proline; Skin

2001
Proline analogue of melphalan as a prolidase-convertible pro-drug in breast cancer MCF-7 cells.
    Folia histochemica et cytobiologica, 2001, Volume: 39 Suppl 2

    Topics: Antineoplastic Agents, Alkylating; Breast Neoplasms; Dipeptidases; Female; Humans; Melphalan; Prodrugs; Proline; Tumor Cells, Cultured

2001
Proline analogue of melphalan as a prodrug susceptible to the action of prolidase in breast cancer MDA-MB 231 cells.
    Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:11

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dipeptidases; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Melphalan; Prodrugs; Proline

2003
Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy.
    Biochemistry, 2004, May-25, Volume: 43, Issue:20

    Topics: Animals; Antibodies; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Directed Molecular Evolution; Drug Design; Enzyme Stability; Humans; Immunoconjugates; Melphalan; Mice; Molecular Structure; Peptides; Prodrugs; Proline; Prolyl Oligopeptidases; Protein Engineering; Serine Endopeptidases; Toxicity Tests

2004
Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.
    Pharmaceutical research, 2007, Volume: 24, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Biological Transport; Biotransformation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlorambucil; Dipeptidases; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrolysis; Inhibitory Concentration 50; Melanoma; Melphalan; Prodrugs; Proline; Protease Inhibitors; RNA, Messenger; Stereoisomerism

2007
Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2007, Volume: 67, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Calorimetry; Cell Proliferation; Chromatography, High Pressure Liquid; Female; Hydrolysis; Indicators and Reagents; Melanoma, Experimental; Melphalan; Mice; Mice, Inbred C57BL; Prodrugs; Proline; Spectrophotometry, Ultraviolet; Stereoisomerism; Survival Analysis

2007
Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Dec-15, Volume: 191, Issue:12

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; B-Lymphocytes; bcl-2-Associated X Protein; Caspases; Cell Transformation, Viral; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Melphalan; Mitochondria; Neoplasm Proteins; Nuclear Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Protein Interaction Mapping; Protein Isoforms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins; Pyridines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transcriptional Activation; Tumor Protein p73; Tumor Suppressor Proteins; Xeroderma Pigmentosum Group A Protein

2013
Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers.
    Molecular pharmaceutics, 2014, Dec-01, Volume: 11, Issue:12

    Topics: Animals; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Dipeptides; Dipeptidyl Peptidase 4; Humans; Melphalan; Neoplasms; Oligopeptides; Prodrugs; Proline; Swine

2014