proline and leucine

proline has been researched along with leucine in 1661 studies

Research

Studies (1,661)

TimeframeStudies, this research(%)All Research%
pre-1990680 (40.94)18.7374
1990's174 (10.48)18.2507
2000's265 (15.95)29.6817
2010's325 (19.57)24.3611
2020's217 (13.06)2.80

Authors

AuthorsStudies
Akamatsu, M; Asao, M; Fujita, T; Iwamura, H1
Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H1
Brandsch, M; Gebauer, S; Laug, L; Schäfer, S; Thondorf, I; Voigt, V; Zebisch, K1
Bartnik, E; Piotrowska, M; Stepień, PP; Zakrzewska, E1
Burrill, PH; Lerner, J; Sattelmeyer, PA1
Dell, J; Toome, V; Wegrzynski, B1
Lichtman, MA; Peck, WA; Rockwell, LH1
Björkman, S; Castensson, S; Lindeke, B; Sievertsson, H1
Chen, RF; Maly, M; Smith, PD1
Higashijima, T; Miyazawa, T; Miyoshi, M; Tasumi, M1
Kutzman, RS; Roberts, JF1
Barber, PC; Field, PM1
Kleinkauf, H; Vater, J1
Minckler, DS; Tso, MO1
Dabrowa, N; Howard, DH1
Conrad, LC; Pfaff, DW2
Beitz, AJ1
Cowan, WM; Saper, CB; Swanson, LW1
Cowan, WM; Loewy, AD; Saper, CB; Swanson, LW1
Minckler, DS; Tso, MO; Zimmerman, LE1
Agranoff, BW; Heacock, AM1
Hall, WC; Skeen, LC1
Cowan, WM; Swanson, LW1
Coulter, JD; Jones, EG1
Künzle, H2
Gross, GW; Kreutzberg, GW1
Gross, GW; Kreutzberg, GW; Krygier-Brévart, V; Weiss, DG1
Casseday, JH; Jones, DR1
Bonke, BA; Bonke, D; Scheich, H1
Hashikawa, T; Kawamura, K1
Fallon, JH; Moore, RY1
Engström, C; Jontell, M; Linde, A1
Kendall, A; Lehmann, H; Oune, N; Wiltshire, B; Young, S1
Dingle, JT; Meikle, MC; Reynolds, JJ; Sellers, A1
Kilroe-Smith, TA; McLoughlin, JL1
Hajek, AS; Solursh, M1
Anraku, Y; Kin, E1
Baker, RA; Hubbard, JS; Rinehart, CA1
Hilf, R; Hissin, PJ2
Lee, SG; Lipmann, F1
Leushner, J; Pasternak, J1
Frey, KL; Haralson, MA; Mitchell, WM1
Renvall, S1
Hempel, K; Romen, W1
Adams, E; Heacock, AM1
Basset, P; Beuzard, Y; Braconnier, F; Caburi, J; el Gammal, H; Martin, L; Oudard, JL; Thillet, J1
Gacon, G; Jones, RT; Koler, RD; Labie, D; Wajcman, H1
Sodek, J1
Ashman, PU; Newport, GR; Page, CR; Seed, JR; Stibbs, HH1
Kniewald, Z; Kordić, D1
Desai, SM; Weiss, SB1
Calvo, JM; Davis, MG1
Hatfield, GW; Lawther, RP; Oxender, DL; Quay, SC1
Herrington, MB; Kapoor, V; Newman, EB; Tam, A1
Carter, BL; Ehrhardt, CW; Johnston, GC; Lorincz, A1
Scarpulla, RC; Soffer, RL1
Robertson, JH; Wheatley, DN1
Downing, SJ; Kowaloff, EM; Phang, JM; Smith, RJ; Valle, D1
Cohen, P; Convert, O; Di Bello, C; Griffin, JH; Nicolas, P1
Kaplan, J; Murray, LW; Rowland, FN; Tanzer, ML1
Milsom, JP; Morgan, MY; Sherlock, S1
Davidson, CS; Fernstrom, JD; Hammarstrom-Wiklund, B; Munro, HN; Rand, WM; Wurtman, RJ2
Bailey, RS; Fried, B1
Dall'asta, V; Gazzola, GC; Guidotti, GG2
Habowsky, J; Lupulescu, A1
Türet, S1
Das, HK; Subrahmanyam, CS1
Pantyukhova, VV; Pekhov, AP; Rudneva, SN1
Cruce, JA1
Vary, JC1
Hoare, DS; Hoare, L; Patel, R; Taylor, BF1
Butler, M; Capindale, JB1
Anda, LP; Dotchev, D; Liappis, N1
Hempel, K; Romen, W; Schultze, B1
Deutsch, HF; Fett, JW1
Goldman, PS; Nauta, WJ1
Bayley, HS; Chavez, ER1
Askenasi, R; Gregoire, F1
Lupulescu, AP1
Nakayama, T; Narita, K1
Iwase, H; Murai, A1
Robinson, JH1
Matsuoka, M; Miyaji, T; Ohba, Y; Sugiura, T; Sugiyama, K; Suzuki, T1
Berg, A; Keul, J1
Brack, A1
Berkley, KJ; Graham, J; Jones, EG1
Nakayama, T; Narita, K; Ogata, K1
Grathwohl, C; Wüthrich, K1
Deslauriers, R; Grzonka, Z; Walter, R1
Granger, AS; Kowaloff, EM; Phang, JM1
Corley, CC; Gravely, M; Huisman, TH; Milner, PF; Pomeroy, WL; Wilson, JB1
Counahan, R; Cox, BD; El-Bishti, M; Ogg, CS1
Horváth, M; Mestyán, J; Schultz, K; Soltész, G1
Baccetti, B; Burrini, AG; Pallini, V1
Lowe, NR; Robinson, C; Weatherell, JA1
Lee, M; Oxender, DL; Robbins, JC1
Barak, Z; Gilbarg, C1
Anraku, Y; Goto, F; Kin, E1
Kirshner, N; Schramm, M; Wallach, D1
Cruce, JA; Cruce, WL1
Del Pra, A; Scatturin, A; Tamburro, AM1
Baum, BJ; Franzblau, C; Johnson, LS; Troxler, RF1
Coy, DH; Dupont, A; Kastin, AJ; Labrie, F; Pelletier, G; Puviani, R; Schally, AV1
Dessauer, PL; Hubbard, M; Huisman, TH; Lindeman, JG; Wilson, JB; Winton, EF; Wrightstone, RN1
Bhatnager, RS; Rapaka, RS1
Havran, RT; Roy, J; Schwartz, IL; Walter, R1
Jones, EG1
Price, JL; Sprich, WW1
Bordignon, E; Scatturin, A; Tamburro, AM; Vidali, G1
Marks, N; Neidle, A; Walter, R1
Eisenbach, GM; Stolte, H; Weise, M1
Feldherr, CM1
Berkley, KJ1
Ivano, E; Kr"steva, A; Lozanova, L; Nedkov-Bratanova, N; Nikolov, N1
Lupulescu, A1
Bordignon, E; Del Pra, A; Scatturin, A; Tamburro, AM1
Fendler, JH; Nagyvary, J; Nome, F1
Modin, R; Nordgren, T1
Guadalix, FJ; Ruiz, MC1
Agosti, S; Baffico, M; Cao, A; Melevendi, C; Murru, S; Pirastu, M; Poddie, D; Sciarratta, GV1
Bijvoet, SM; Hayden, MR1
Vilsen, B1
Adefarati, AA; Hensens, OD; Jones, ET; Tkacz, JS1
Desviat, LR; Pérez, B; Ugarte, M1
Hasegawa, Y; Kayahara, T; Kohno, M; Nakano, K; Sasaki, K; Tokushige, A1
Buchberg, AM; Kosaras, B; Moskow, JJ; Shooter, EM; Sidman, RL; Snipes, GJ; Suter, U; Welcher, AA1
Bale, SJ; Chipev, CC; Compton, JG; DiGiovanna, JJ; Korge, BP; Markova, N; Steinert, PM1
Baraitser, M; Malcolm, S; Rutland, P; Strautnieks, S; Winter, RM1
Desnick, RJ; Levran, O; Schuchman, EH1
Buddington, RK; Puchal, AA; Vega, YM1
Barrow, CJ; Nakanishi, K; Tachibana, K1
Colbert, JT; Held, BM; John, I; Wang, H; Wurtele, ES1
Barz, D; Eckhardt, CM; Kiefel, V; Kuijpers, RW; Ouwehand, WH; Taaning, E; Termijtelen, A; von dem Borne, AE; Waters, AH; Zupanska, B1
Apfelstedt-Sylla, E; Gal, A; Horn, M; Kunisch, M; Rüther, K; Zrenner, E1
Brennan, SO; George, PM; Higuchi, R; Myles, T; Symmans, WA; Williamson, D1
Caso, R; Dawes, J; Lane, DA; Morris, HR; Olds, RJ; Panico, M; Sas, G; Thein, SL1
Kaji, T; Kawashima, T; Sakamoto, M; Yamamoto, C1
Anderson, AG; Hermans, J; Yun, RH1
Naess, O; Nicolaissen, B; Ringvold, A1
Hsiao, K; Prusiner, SB1
DeArmond, SJ; Foster, D; Groth, D; Hsiao, K; Prusiner, SB; Scott, M; Serban, H1
Graybiel, AM; Ragsdale, CW2
Glickstein, M; May, J; Mercier, B1
DaRosso, R; Espinola, R; Flug, F; Karpatkin, S; Liu, LX; Nardi, M; SinQuee, C1
Tanno, Y; Tsuji, S; Yoneda, M1
Feig, S; Harting, JK; Van Lieshout, DP1
Burke, JF; Jaksic, T; Wagner, DA; Young, VR1
Gudnason, V; Humphries, S; King-Underwood, L; Knight, B; Patel, D; Seed, M; Soutar, A1
Killeen, AA; Orr, HT; Sane, KS1
Berg, A; Goldberg, L; Grabowski, GA; Grace, ME; He, GS; Horowitz, M1
Amioka, H; Dojo, S; Hayashi, K; Hiraoka, M; Hirata, Y; Kurushima, H; Nakashima, K; Nishio, E; Ohtani, H; Saeki, M1
Barbato, G; Bax, A; Ikura, M; Kay, LE; Krinks, M; Spera, S1
Dekker, JJ; Goldman-Rakic, PS; Schwartz, ML1
Klinkhamer, MP; Krans, HM; Maassen, JA; Möller, W; Van der Vorm, ER; Van der Zon, GC1
Asakura, H; Iwanaga, S; Kajiyama, S; Kumabashiri, I; Matsuda, T; Miyata, T; Saito, M; Uotani, C1
Masuno, M; Orii, T; Sukegawa, K; Tomatsu, S1
Béliveau, R; Demeule, M; Jetté, M; Potier, M1
Chen, SA; Pompon, D; Zhou, DJ1
Maeda, M; Yoshida, A1
Berson, EL; Dryja, TP; Rosner, B; Sandberg, MA; Weigel-DiFranco, C1
Hamm, G; Lemmen, C; Willershausen-Zönnchen, B1
Asakura, S; Hirata, H; Matsuda, M; Okuma, M; Yamazumi, K; Yoshida, N1
Dumic, M; New, MI; Speiser, PW; Tusie-Luna, MT; White, PC1
Munck, BG; Munck, LK1
Mason, JI; Mathew, PA; Sanders, D; Trant, JM; Waterman, MR1
Charbonneau, M; Mori, Y; Refetoff, S; Takeda, K1
Baranton, G; Margarita, D; Richaud, C; Saint Girons, I1
Courtois, Y; Galera, P; Haloui, Z; Laurent, M; Pujol, JP1
Bellon, G; Borel, JP; Gillery, P; Maquart, FX; Wegrowski, Y1
Jaksic, T; Wagner, DA; Young, VR1
Bolen, FA; Hammerschlag, R; Stone, GC1
Brauth, SE; Kitt, CA1
Berkley, KJ; Contos, N1
Koike, H1
Wild, JM1
Giguere, M; Goldman-Rakic, PS1
Groen, NA; Klinkhamer, MP; Krans, HM; Lindhout, D; Maassen, JA; Möller, W; Sandkuyl, LA; van der Zon, GC1
Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z1
Brody, LC; Engelhardt, JF; Kaiser-Kupfer, M; Looney, JE; Mitchell, GA; Obie, C; Patel, AS; Sipila, I; Steel, G; Wong, C1
Byers, MR; Dong, WK1
Aster, RH; Derbes, RS; Newman, PJ1
Ahl, PL; Khorana, HG; Mogi, T; Rothschild, KJ; Stern, LJ1
Bowie, JU; Patel, DJ; Sauer, RT; Vershon, AK; Zagorski, MG1
Cooper, HM; Magnin, M; Mick, G1
Bayreuther, K; Pfleiderer, G; Rodemann, HP1
Doh-ura, K; Kitamoto, T; Sakaki, Y; Sasaki, H; Tateishi, J1
Crystal, RG; Frants, RR; Hofker, MH; Klasen, EC; Kramps, JA; Nelen, M; Nukiwa, T; van Paassen, HM1
Delaunay, J; Francina, A; Galacteros, F; Rosa, J; Wajcman, H1
Beckstead, RM; Bromley, S; Gracco, C; Royce, GJ1
Beckstead, RM; Segal, RL1
Fukumaki, Y; Kobayashi, Y; Komatsu, N; Miura, Y; Miyaji, T; Ohba, Y1
Harms, E; Umbarger, HE1
Battaglini, PP; Galletti, C; Maioli, MG; Squatrito, S1
Yee, JA1
Lowe, PN; Rowe, AF1
Absher, PM; Arnold, J; Hildebran, JN; Low, RB; Stirewalt, WS1
Borghetti, AF; Gandolfi, SA; Petronini, PG1
Albrich, JM; Callahan, KB; Gilbaugh, JH; Hurst, JK1
Cami, B; Chippaux, M; Fons, M; Patte, JC1
Chang, JY; Tran, TH1
Arme, C; Jeffs, SA1
Carter, S; Diamond, J; Hughes, M; Karasov, W; Phan, D; Solberg, D; Zollman, F1
Kato, H; Naito, H; Nam, TJ; Noguchi, T1
François, C; Percheron, G; Tandé, D; Yelnik, J1
Sakai, ST1
Gentz, R; Ibrahimi, I1
Cohen, DH; Gamlin, PD1
Pandya, DN; Yeterian, EH1
Blanks, RH; Giolli, RA; Torigoe, Y1
Fómez-Pinilla, F; Hovda, DA; Sonnier, BJ; Villablanca, JR1
Henderson, J; Kaye, M1
Barile, FA; Bienkowski, RS; Ripley-Rouzier, C; Siddiqi, ZE1
Franzblau, C; Goldstein, RH; Meeker, D; Polgar, P; Sakowski, S1
Berkley, KJ; Contos, N; Elam, JS1
Dennis, BJ; Kerr, DI; Krantis, A1
Pandya, DN; Seltzer, B2
Grigonis, AM; Murphy, EH; Pearson, HE1
Barrett, J; Grantham, BD1
Karten, HJ; Reiner, A1
Frick, L; Wolfenden, R1
Feldman, JL; Loewy, AD; Speck, DF1
Brunette, DM; Hasegawa, S; Saito, S; Sato, S; Suzuki, Y1
Chang, SD; Diamond, JM; Hughes, M; Karasov, WH; Solberg, DH; Stein, ED1
Pandya, DN; Rockland, KS1
Carvajal, N; Cederbaum, SD1
Behan, M1
Adams, WC; Frieden, EH1
Belzberg, H; Coleman, B; Pittiruti, M; Placko, R; Sganga, G; Siegel, JH; Wedel, S; Wiles, CE1
Oliver, DL1
Andersen, RA; Asanuma, C; Cowan, WM1
Kuznetsova, VS; Orlova, TI; Silaev, AB1
Forman, DS; Grafstein, B; McEwen, BS1
Caplan, AI2
Jacob, J1
Smith, BH1
Alvarez, J; Püschel, M1
Karlsson, JO; Sjöstrand, J1
Grafstein, B; Ingoglia, NA; Murray, M1
Itano, HA; Kawasaki, I1
Lenn, NJ; Moore, RY1
Copeland, T; Gilden, RV; Oroszlan, S; Summers, M1
Hall, MD; Hyde, RD; Lehmann, H; Wiltshire, BG1
Grafstein, B; Laureno, R1
Schafer, R1
Meier, RE1
Cowan, WM; Crossland, WJ; Kelly, JP1
Moore, RY1
Kirschbaum, JB1
Bryce, GF1
Karlson, JO; Marchisio, PC; Sjöstrand, J1
Cuénod, M; Künzle, H1
Laland, SG; Pass, L; Zimmer, TL1
Imae, Y; Kambe, M; Kurahashi, K1
McClure, WO; Schlichter, DJ1
Agulnek, MA; Cowan, WM; Price, JL; Wann, DF1
Carpenter, MB; Pierson, RJ1
Agranoff, BW; Elam, JS; Neale, EA; Neale, JH1
Balcar, VJ; Johnston, GA1
Hare, JF; Kennedy, EP; Olden, K1
Burrill, P; Lerner, J; Miller, DS1
Bentley, PH; Gregory, RA; Grossman, MI; Tracy, HJ1
De Lorenzo, F; Givol, D1
Diamond, S; Hansen, S; Perry, TL; Stedman, D1
Boos, W; Shen, BH1
Chase, TN; Lipton, MA; Morris, CE; Woods, AC1
Castensson, S; Lindeke, B; Sievertsson, H; Sum, CY1
Banerjee, AB; Bhattacharyya, SK1
Karcher-Djuricic, V; Moullec, N; Ruch, JV1
Karcher-Djuricic, V; Ruch, JV1
Miyazawa, Y; Sekine, T; Yamaguchi, M1
Hansen, S; Lesk, D; Perry, TL1
Boyer, PD; Klein, WL1
Meier, S; Solursh, M1
Elam, JS1
Lal, D; Schedl, HP1
Reiter, RS; Solursh, M; Vaerewyck, SA1
Fabre, M; Karcher-Djuricic, V; Ruch, JV; Stäubli, A1
Shapiro, BM; Stadtman, ER1
Manahan, J; Mandl, I2
Borghetti, AF; Guidotti, GG; Lüneburg, B1
Gregson, N; Hamberger, A; Lehninger, AL1
Hussa, RO; Winnick, M; Winnick, T1
Laufs, R; Walker, W1
Gevers, W; Kleinkauf, H1
Fujikawa, K; Imae, Y; Kambe, M; Kurahashi, K; Mori, K; Sakamoto, Y; Sato, E; Takahashi, H; Yamada, M1
Kaback, HR; Milner, LS1
Downing, SJ; Phang, JM; Weiss, IW1
Lanks, KW; Weinstein, IB1
von Bruchhausen, F1
Jaeger, E; Schönsteiner-Altmann, G; Wünsch, E1
Morgan, K; Phang, JM; Weiss, IW1
Marks, N; Walter, R1
Iwaki, M; Kaji, E; Kanda, M; Saito, Y; Shimura, K1
Hamberger, L; Herlitz, H; Sjögren, A1
Bayliss, ME; Prescott, JM; Wilkes, SH1
Gnarra, DJ; Green, D; Honig, GR; Mason, RG; Maurer, HS; Shamsuddin, M; Vida, LN1
Brecher, AS; Simmons, WH1
Perdue, JF; Wray, VP1
Heinemann, S; Humphreys, S; Patrick, J; Schubert, D; Tarikas, H1
Hogan, BL; Murden, S1
Crippa, PR; Tedeschi, RA; Vecli, A1
Felix, D; Künzle, H1
Barrett, JC; Miller, PS; Ts'o, PO1
Ikenaka, T; Murao, S; Nabeshima, Y; Odani, S; Sakai, M; Sato, S1
Anderer, FA; Wittmann, HG; Wittmann-Liebold, B1
Chandra, P; Lingens, F; Süssmuth, R; Wacker, A1
Jaenicke, R; Jockusch, H; Koberstein, R1
Nishikimi, M; Oishi, N; Takai, A; Yagi, K2
Guilbault, GG; Hieserman, JE1
Kastin, AJ; Nair, RM; Schally, AV1
Kuhn, J; Somerville, RL1
Barooshian, AV; Greenwood, JM; Harris, WG; Lautenschleger, MF1
Burrill, P; Lerner, J1
Galoyan, A; Grynbaum, A; Lajtha, A; Marks, N1
Caruthers, JS; Lorenzo, AV1
Kitagawa, H; Mori, T; Riggs, TR1
Cowan, WM; Jones, EG; Swanson, LW1
Edwards, SB; Palmer, LA; Rosenquist, AC1
Brown, AS; Troxler, RF1
Dancis, J; Schneider, H1
Fifkova, E; Van Harreveld, A1
Lindig, OH; Mitlin, N; Thompson, AC; Wiygul, G1
Wajgt, A; Wender, M; Zgorzalewicz, B1
Shotts, WJ; Sievers, AJ1
Crossley, AC; Evans, PD1
el-Sewefy, AZ; Hegazi, SM1
Palau, J; Puigdoménech, P1
Bonner, WA2
Friedmann, N; Miller, SL; Ring, D; Wolman, Y1
Arregui, A; Bennett, JP; Logan, WJ; Snyder, SH1
Wright, EM1
Clark, DE; Grant, NH; Rosanoff, EI1
Scalia, F1
Flickinger, RA; Rollins, JW1
De Haan, PG; Hoekstra, WP; Verhoef, C1
Arimura, A; Hashimoto, T; Kaneko, T; Kenmochi, Y; Oka, H; Saito, S; Schally, AV; Yanaihara, C; Yanaihara, N1
Nair, RM; Schally, AV1
Arimura, A; Hashimoto, T; Kaneko, T; Schally, AV; Tsuji, K; Yanaihara, C; Yanihara, N1
Ferrell, L; Kastin, AJ; Miller, MC; Schally, AV1
Miller, EJ1
Sunde, ML1
Adelberg, EA; Bergquist, PL1
Morris, H; Schlesinger, MJ1
Gylfe, E1
Boyle, SM; Sells, BH1
Dworsky, P1
Kemper, J2
Ozeki, H; Sakano, H; Shimura, Y1
Christensen, HN; Quay, S1
Halpern, YS1
Cowan, WM; Hendrickson, AE; Wagoner, N1
Fekl, W1
Anderson, MS; Kastin, AJ; Plotnikoff, NP; Schally, AV1
Jost, R; Masson, A; Zuber, H1
Barbeau, A; Kastin, AJ1
Bradbury, JH; Ley, KF1
Alimov, IIu; Iur'eva, EA; Marchenko, ZM1
Okano, T; Sato, Y1
Tobin, MC1
Labie, D; Solal, MC1
Cheeseman, CI; Smyth, DH1
Betz, AL; Gilboe, DD1
Kastin, AJ; Nair, RM; Redding, TW; Schally, AV1
Exss, RE; Summer, GK1
Caspary, WF; Creutzfeldt, W1
Denamur, R; Gaye, P; Houdebine, L1
Gruber, L; Harris, JE1
Johnson, DE; Sellinger, OZ1
Graybiel, AM; Lasek, RJ; Nauta, HJ; Nauta, WJ1
Balsamo, J; Brentani, R; Marques, N; Myiashita, M; Stolf, AM; Wang, L1
Kuznar, J; Magaña-Schwencke, N; Schwencke, J1
Friedman, E; Friedman, J; Gershon, S1
Glasel, JA; Hruby, VJ; McKelvy, JF; Spatola, AF1
Trayhurn, P; van Heyningen, R1
Hook, DJ; Vining, LC1
Beuttel, SC; Eisenbarth, GS; Lebovitz, HE1
Geerstsen, EA; Gibbons, GC; Strobaek, S1
Harik, SI; North, RB; Snyder, SH1
Gruhn, K1
Rea, C; Reynolds, R; Segal, S1
De Coen, JL; Ralston, E1
Kent, C; Williams, MA1
Cowan, WM; Crossland, WJ; Kelly, JP; Rogers, LA1
Cuénod, M; Meier, RE; Mihailovic, J1
Bergström, J; Fürst, P; Norée, LO; Vinnars, E1
Allen, NK; Baker, DH1
Barrett, FM1
Kastin, AJ; Plotnikoff, NP1
Bartsocas, CS; Crawford, JD; Thier, SO1
Piechowski, A; Wender, M; Zgorzalewicz, B1
Bergeron, M; Dubord, L1
Gröger, D; Johne, S2
Cutroneo, KR; Prichard, PM; Staton, GW1
Kolaskar, AS; Ramachandran, GN; Ramakrishnan, C; Sasisekharan, V1
Kastin, AJ; Minard, FN; Plotnikoff, NP1
Dworak, W; Tustanowski, S2
Mizuno, S; Nitta, K; Umezawa, H1
Shaw, MK1
Chow, RB; Kassel, B1
Lin, YC; Tanaka, N1
Milstein, CP1
Koehn, PV; Perlmann, GE1
Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y1
Ekert, B; Monier, R; Tordjman, A1
Ilan, J1
Holden, JT; Wilson, OH1
Breitman, TR; Finkleman, A; Rabinovitz, M; Reagan, RL1
Roberts, S1
Egyházi, E1
Generalov, OV1
Cerná, J; Chládek, S; Pulkrábek, P; Rychlík, I; Zemlicka, J1
Fraenkel-Conrat, H; Singer, B1
Berg, CM; Rossi, JJ1
Swanson, RF1
Bremer, H; Brunschede, H1
Dunlap, BE; Friderici, KH; Rottman, F1
Arimura, A; Baba, Y; Matsuo, H; Nair, RM; Schally, AV1
Hoare, DS; Hoare, SL; Taylor, BF1
Breitman, TR; Finkleman, A; Rabinovitz, M1
Kotyk, A; Ponec, M; Ríhová, L1
Daughaday, WH1
Glimcher, MJ; Huddleston, J; Levine, PT; Seyer, J1
Campbell, JJ; Tomlinson, GA1
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Gruca, A; Grynberg, M; Plewczynski, D; Tatjewski, M1
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Fajkusová, L; Freiberger, T; Pavloušková, J; Réblová, K; Tichý, L1
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Chen, H; Chen, Z; Da, Y; Di, L; Liu, Z; Previch, L; Wang, W1
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Beavers, K; Bernstein, D; Brainard, DM; Chung, RT; Davis, M; Dvory-Sobol, H; Etzkorn, K; Everson, G; Gane, EJ; Gordon, SC; Khalid, O; Kowdley, KV; Kwo, PY; Lu, S; McHutchison, JG; Nguyen, MH; Poulos, JE; Pound, D; Rodriguez-Torres, M; Stamm, LM; Stedman, CA; Tong, M; Tsai, N; Yang, JC1
Bennett, M; Brainard, DM; Curry, M; Dvory-Sobol, H; Hawkins, T; Herring, R; Hinestrosa, F; Jacobson, I; Lawitz, E; Lu, S; McHutchison, JG; Nahass, R; Pearlman, B; Rabinovitz, M; Reau, N; Reddy, KR; Schiff, E; Sheikh, A; Shiffman, M; Stamm, LM; Tran, T; Yang, JC; Younes, Z1
Berger, KL; Côté-Martin, A; Kukolj, G; Marquis, M; Mensa, FJ; Nelson, DR; Sarrazin, C; Scherer, J; Sha, N; Stern, JO; Vinisko, R1
Cheng, L; Li, JY; Li, NN; Lu, ZJ; Peng, R; Sun, XY; Tan, EK; Wang, L; Zhang, JH1
Hannongbua, S; Kungwan, N; Meeprasert, A; Rungrotmongkol, T1
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Asatryan, A; Campbell, A; Chiu, YL; Clifton, J; Dutta, S; Lin, CW; Liu, W; Wang, H1
Bai, X; Calleja, JL; Forns, X; Garcia-Samaniego, J; Kaste, R; Manns, M; Sarrazin, C; Stern, JO; Wu, J1
Asatryan, A; Bernstein, DE; Felizarta, F; Flamm, SL; Fried, MW; Gordon, SC; Kort, J; Landis, CS; Lin, CW; Liu, R; Lovell, SS; Mensa, FJ; Ng, TI; Poordad, F; Reindollar, RW; Sulkowski, MS1
Abbar, M; Al Bouzidi, A; Ameur, A; Ameziane El Hassani, R; Attaleb, M; Dakka, N; El Mzibri, M; Hadami, K1
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Lim, SG1
Agarwal, K; Asselah, T; Berg, T; Bhandari, BR; Borgia, SM; Brainard, DM; Bräu, N; Davis, M; Dore, GJ; Dvory-Sobol, H; Feld, JJ; Foster, GR; Gane, EJ; Hyland, RH; Jacobson, IM; Lawitz, E; McHutchison, JG; Nahass, RG; Pearlman, B; Roberts, SK; Ruane, PJ; Shafran, SD; Stamm, LM; Stedman, CAM; Subramanian, GM; Svarovskaia, E; Thompson, AJ; Willems, BE; Workowski, KA; Zhu, Y1
Agarwal, K; Aguilar, H; Asatryan, A; Dore, GJ; Felizarta, F; Gane, E; Gordon, SC; Hassanein, T; Kort, J; Kwo, PY; Lin, CW; Liu, R; Lovell, SS; Maliakkal, B; Mensa, FJ; Muir, AJ; Ng, TI; Overcash, JS; Poordad, F; Sulkowski, MS; Wang, S; Wyles, DL1
Bowman, ML; Casey, L; Christensen, H; James, P; Kahr, WHA; Li, L; Lillicrap, D; Pluthero, FG; Robinson, KS; Tuttle, A1
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Iwasaki, A; Matsubara, T; Sato, T; Shiota, I; Suenaga, K; Sumimoto, S1
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Jacobson, IM; Voaklander, R1
Bédard, AC; Collins, SK; Godin, É; Raymond, M1
Asatryan, A; Campbell, A; Dutta, S; Lin, CW; Liu, W; Zhao, W1
Arias, A; Barreiro, P; Benítez-Gutiérrez, L; Carrasco, I; de Mendoza, C; Peña, JM; Soriano, V1
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Asatryan, A; Geoffroy, P; Kort, J; Kosloski, MP; Liu, W; Zhao, W1
Aguilar, H; Felizarta, F; Forns, X; Ghalib, R; Hassanein, T; Hinrichsen, H; Horsmans, Y; Kort, JJ; Krishnan, P; Lee, SS; Lens, S; Lin, CW; Mensa, FJ; Morillas, R; Nelson, DR; Rincon, D; Valdes, J; Yu, Y; Zeuzem, S1
Alves, K; Atarashi, T; Atsukawa, M; Burroughs, M; Chayama, K; Fu, B; Kato, K; Kumada, H; Naganuma, A; Nakamuta, M; Notsumata, K; Oberoi, RK; Osaki, Y; Pilot-Matias, TJ; Pugatch, D; Redman, R; Saito, S; Sato, K; Suzuki, F; Takaguchi, K; Toyoda, H; Watanabe, T1
Agarwal, K; Alric, L; Felizarta, F; Hassanein, T; Kort, J; Krishnan, P; Kwo, PY; Lee, SS; Lin, CW; Liu, R; Lovell, SS; Maliakkal, B; Mensa, FJ; Pilot-Matias, T; Poordad, F; Wang, S; Weilert, F; Wyles, D1
Lamb, YN1
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Agarwal, K; Aguilar, H; Asselah, T; Calinas, F; Colombo, M; de Ledinghen, V; Elkhashab, M; Hassanein, T; Hezode, C; Horsmans, Y; Kort, J; Kowdley, KV; Krishnan, P; Lin, CW; Liu, R; Mantry, PS; Marinho, RT; Mensa, FJ; Nevens, F; Ng, TI; Wang, S; Zadeikis, N1
Deangeli, G; Di Monte, DA; Migdalska-Richards, A; Rusconi, R; Schapira, AHV; Spillantini, MG; Wegrzynowicz, M1
Du, W; Gou, X; Hu, J; Liang, L; Liu, W; Zuo, K1
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Conforti, FL; Di Fini, F; La Bella, V; Lo Bello, M; Notaro, A; Spataro, R1
Birnkrant, D; Chan-Tack, K; Naeger, LK; Qi, K; Struble, K1
Brainard, DM; Cheng, G; Dvory-Sobol, H; Lawitz, E; Miller, MD; Mo, H; Stamm, LM; Taylor, JG; Yang, JC1
Aschenbrenner, DS2
Kottilil, S; O'Brien, TR; Pfeiffer, RM1
Chahine, EB; Childs-Kean, LM; Kelley, D1
Asatryan, A; Bernstein, DE; Buti, M; Felizarta, F; Fried, MW; Gallant, J; Gordon, SC; Hézode, C; Kopecky-Bromberg, S; Kort, J; Krishnan, P; Lei, Y; Lin, CW; Mensa, FJ; Ng, TI; Pianko, S; Pol, S; Poordad, F; Reindollar, RW; Shaw, D1
Bourliere, M; Cooper, C; Flamm, S; Gordon, S; Hunt, S; Jacobson, I; Kowdley, K; Mann, MP; Reddy, KR; Stepanova, M; Younossi, I; Younossi, ZM; Zeuzem, S1
Li, GF; Yu, G; Zhou, HH1
Forns, X; Mensa, FJ1
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Asselah, T; Foster, GR; Gane, EJ; Henry, L; Jacobson, IM; Lawitz, E; Pearlman, B; Racila, A; Roberts, SK; Stepanova, M; Thompson, AJ; Welzel, TM; Willems, BE; Younossi, I; Younossi, ZM1
Besandre, R; Liu, HW1
Hubbard, H; Lawitz, E1
Kurt Yilmaz, N; Matthew, AN; Schiffer, CA1
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Hussar, DA1
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Younossi, ZM1
Danta, M; Sanagapalli, S1
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Huang, F; Rowland, L; Sabo, JP; Schultz, A; Trampisch, M; Voelk, C1
Carrion, AF; Martin, P1
Liu, W; Oberoi, RK; Sidhu, DS; Trinh, R; Viani, RM; Zhao, W1
Debes, JD; Singh, D1
Cavanaugh, J; French, JA; Mustoe, A1
Deeks, ED; Heo, YA1
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Forde, KA; Sawinski, D; Wyatt, CM1
Abe-Chayama, H; Aikata, H; Chayama, K; Hayes, CN; Imamura, M; Ishida, Y; Makokha, GN; Miki, D; Ochi, H; Osawa, M; Tateno, C; Teraoka, Y; Tsuge, M; Uchida, T1
Cory, TJ; Gong, Y; Kodidela, S; Kumar, S; Mu, Y1
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Amat, R; Bahri, M; Barceló-Coblijn, G; Campbell, M; Carobbio, S; Dias, AR; Gray, SL; Prieur, X; Relat, J; Rodriguez-Cuenca, S; Vidal-Puig, A1
Chai, J; Deng, K; Diao, Q; Nie, M; Qi, M; Wang, H; Zhang, N; Zhao, J1
Allmann, S; Bertiaux, E; Biran, M; Bouyssou, G; Bringaud, F; Crouzols, A; Dittrich-Domergue, F; Fouillen, L; Kiema, TR; Mazet, M; Millerioux, Y; Moreau, P; Plazolles, N; Rotureau, B; Thapa, C; Wierenga, RK1
Abutaleb, A; Kottilil, S; Wilson, E1
Waked, I1
Bourlière, M; Brainard, DM; Curry, MP; Dvory-Sobol, H; Gordon, SC; Hyland, RH; Landis, CS; Manns, MP; McHutchison, JG; Ravendhran, N; Reddy, KR; Schiff, ER; Sepe, TE; Serfaty, L; Stamm, LM; Subramanian, GM; Thompson, AJ; Tran, TT; Zhang, J1
Summers, BB1
Bourliere, M; Gordon, SC; Manns, MP; Racila, A; Reddy, R; Schiff, E; Stepanova, M; Tran, T; Younossi, I; Younossi, ZM1
Beyer, J; Collins, C; Dekhtyar, T; Irvin, M; Krishnan, P; Larsen, L; Mensa, FJ; Ng, TI; Pilot-Matias, T; Reisch, T; Schnell, G; Tripathi, R; Xie, W1
Nehra, V; Rizza, SA; Temesgen, Z1
Akuta, N; Arase, Y; Fujiyama, S; Hosaka, T; Ikeda, K; Kawamura, Y; Kobayashi, M; Kumada, H; Saitoh, S; Sezaki, H; Suzuki, F; Suzuki, Y1
Bourliere, M; Brainard, DM; Camus, G; Cooper, CL; Doehle, BP; Dvory-Sobol, H; Flamm, SL; Gordon, SC; Hyland, RH; Kowdley, KV; Manns, MP; Martin, R; Mo, H; Reddy, KR; Roberts, SK; Sarrazin, C; Stamm, LM; Svarovskia, E; Zeuzem, S1
Asatryan, A; Beyer, J; Campbell, A; Collins, C; Dekhtyar, T; Irvin, M; Kort, J; Krishnan, P; Lawitz, EJ; Lovell, S; Lu, L; Mensa, F; Ng, TI; Pilot-Matias, T; Reisch, T; Schnell, G; Tripathi, R; Yao, B1
Kottilil, S; Mathur, P; Wilson, E1
Beyer, J; Collins, C; Dekhtyar, T; Irvin, M; Krishnan, P; Lu, L; Ng, TI; Pilot-Matias, T; Reisch, T; Schnell, G; Tripathi, R; Xie, W1
Hinds, AE; Pearlman, BL1
Fabrizi, F; Messa, P1
Aikata, H; Chayama, K; Fujino, H; Hayes, CN; Hiramatsu, A; Imamura, M; Kawaoka, T; Miki, D; Morio, K; Murakami, E; Nakahara, T; Ono, A; Osawa, M; Teraoka, Y; Tsuge, M; Uchida, T1
Gane, E; Kort, J; Kosloski, MP; Lawitz, E; Liu, W; Marbury, TC; Mensa, FJ; Preston, RA; Pugatch, D; Wang, H1
Erlich, DR; Grover, A1
Abergel, A; Asselah, T; Gane, E; Lee, SS; Lim, SG; Mahomed, A; Mensa, FJ; Nguyen, K; Nguyen, T; Porcalla, A; Sasadeusz, J; Schnell, G; Wong, F; Yao, BB; Zadeikis, N; Zhang, Z1
Agarwal, K; Asatryan, A; Flamm, S; Gane, E; Heo, J; Horsmans, Y; Kopecky-Bromberg, S; Krishnan, P; Kwo, PY; Lovell, SS; Mensa, FJ; Mutimer, D; Ng, TI; Rockstroh, J; Ruane, PJ; Ryder, SD; Trinh, R; Villa, E; Wang, S; Weiland, O; Welzel, TM; Wyles, DL; Xue, Z1
Caroleo, B; Caroleo, MC; Cimellaro, A; Colangelo, L; De Sarro, G; Di Mizio, G; Gallelli, L; Perticone, M1
Baba, M; Izumi, T; Kawagishi, N; Kimura, M; Maehara, O; Morikawa, K; Nakai, M; Nakamura, A; Natsuizaka, M; Ogawa, K; Ohara, M; Sakamoto, N; Shigesawa, T; Shimazaki, T; Sho, T; Suda, G; Suzuki, K; Umemura, M1
Bondin, M; Cacoub, P; Fabrizi, F; Negro, F1
Cenderello, G; Di Biagio, A; Taramasso, L1
Liu, W; Lovell, S; Mensa, FJ; Pilot-Matias, T1
Aghemo, A; Lleo, A; Plaz Torres, MC1
Aguilar, H; Asatryan, A; Asselah, T; Baumgarten, A; Conway, B; Dore, GJ; Foster, GR; Grebely, J; Gschwantler, M; Hu, Y; Jackson, D; Mensa, FJ; Sherman, KE; Tomasiewicz, K; Wang, S1
Chuang, WL; Crawford, DHG; Dokmeci, AK; Hamid, SS; Ibrahim, A; Jindal, A; Kanda, T; Kao, JH; Kumar, M; Lau, GKK; Lesmana, CRA; McCaughan, GW; Moriyama, M; Omata, M; Sarin, SK; Sharma, BC; Sollano, J; Wasim, J; Wei, L; Yokosuka, O; Yu, ML1
Baba, M; Kawagishi, N; Kimura, M; Maehara, O; Morikawa, K; Nakai, M; Nakamura, A; Natsuizaka, M; Ogawa, K; Ohara, M; Sakamoto, N; Shigesawa, T; Shimazaki, T; Sho, T; Suda, G; Suzuki, K; Umemura, M1
Bjornsti, MA; Blackburn, T; McGarity, S; Onuiri, JE; Placzek, WJ; Whitaker, RH; Wright, CM1
Asatryan, A; Asselah, T; Foster, GR; Kopecky-Bromberg, S; Lei, Y; Mensa, FJ; Trinh, R; Zadeikis, N1
Kubo, T; Nanmoku, K; Shimizu, T; Shinzato, T; Yagisawa, T1
Imai, Y; Kouyama, JI; Mochida, S; Motoya, D; Naiki, K; Nakao, M; Nakayama, N; Sugawara, K; Tomiya, T; Tsuji, S; Uchida, Y; Uemura, H1
Brainard, DM; Dvory-Sobol, H; Gane, EJ; Hyland, RH; Nyberg, L; Ruane, P; Shafran, S; Shao, J; Stamm, LM; Strasser, SI; Tran, T1
Blouin, JL; Gerster, K; Guipponi, M; Lang-Muritano, M; Santoni, F; Schwitzgebel, VM; Stekelenburg, C1
Althoff, CE; Bergfeld, L; Brakemeier, S; Budde, K; Duerr, M; Eckardt, KU; Glander, P; Halleck, F; Lehner, LJ; Marticorena Garcia, SR; Sack, I; Schrezenmeier, EV1
Camus, G; Dvory-Sobol, H; Han, B; Hsieh, D; Lu, J; Martin, R; Mo, H; Parhy, B; Svarovskaia, ES1
French, JA; Mehrotra, S; Murray, TF; Mustoe, AC; Pierce, ML1
Balibrea, N; Franco, A; Gimeno, A; Kanter, J; Merino, E; Moreso, F; Perez Contreras, F; Rodriguez, M; Sancho, A1
Cereb, N; Cho, L; Kaur, A; Lin, PY; Yang, KL1
Brown, A; Dufour, JF; Gordon, SC; Mauss, S; Mensa, FJ; Pilot-Matias, T; Poordad, F; Rodrigues, L; Stoehr, A; Weiland, O; Weilert, F; Wyles, D; Yao, B; Zhang, Z1
Abe, H; Aizawa, Y; Akahane, T; Atsukawa, M; Fukunishi, S; Genda, T; Hotta, N; Ikegami, T; Iwakiri, K; Kondo, C; Kumada, T; Michitaka, K; Nakamuta, M; Nozaki, A; Ogawa, C; Shima, T; Shimada, N; Tachi, Y; Takaguchi, K; Tanaka, Y; Toyoda, H; Tsubota, A; Tsuji, K; Uojima, H; Watanabe, T1
Kiser, JJ1
Asatryan, A; Elkhashab, M; Gane, E; Greenbloom, S; Lin, CW; Liu, W; Mensa, FJ; Mulkay, JP; Nguyen, T; Pilot-Matias, T; Poordad, F; Porcalla, A; Setze, C; Stedman, C; Tran, A; Valdes, J; Wang, S; Wörns, MA; Yu, Y; Zadeikis, N1
Bukh, J; Dietz, J; Fahnøe, U; Filskov, J; Fourati, S; Ghanem, L; Gottwein, JM; Humes, D; Jensen, SB; Krarup, H; Pawlotsky, JM; Pedersen, MS; Pham, LV; Pihl, AF; Ramirez, S; Sarrazin, C; Schønning, K; Serre, SBN; Sølund, CS; Tang, Q; Weis, N1
Back, D; Belperio, P; Bondin, M; Crown, E; Marra, F; Mensa, FJ; Negro, F; Park, C; Pinsky, B; Talal, AH; Zhang, Z1
Idrees, H; Mujtaba, G; Naz, S; Ramzan, M; Sobreira, N; Witmer, PD1
Aghemo, A; Parigi, TL; Torres, MCP1
Angulo-Diaz, V; Lim, JK; Mandimika, C; Maughan, A; Ogbuagu, O; Sadigh, K; Villanueva, M1
Hinds, A; Pearlman, B; Perrys, M1
Appleby, T; Barauskas, O; Chan, K; Cheng, G; Jin, D; Karki, KK; Katana, A; Kato, D; Kobayashi, T; Link, JO; Martinez, R; Ramey, K; Sangi, M; Schrier, A; Schultz, BE; Siegel, D; Taylor, JG; Tran, CV; Villaseñor, AG; Vivian, R; Wang, K; Wang, Y; Yang, CY; Yang, ZY; Zablocki, J; Zipfel, S1
Koike, K; Tanaka, Y; Tateishi, R1
Alajmi, MF; Hassan, I; Hussain, A; Naqvi, AAT; Rehman, T1
Chua, J; Comstock, E; Covert, E; Emmanuel, B; Hoffmann, J; Husson, J; Kattakuzhy, S; Kottilil, S; Masur, H; Mathur, P; Price, A; Rosenthal, E; Tang, L; Wilson, E1
Aglitti, A; Brancaccio, G; Caroleo, B; Claar, E; Coppola, C; Coppola, N; Cozzolongo, R; Di Costanzo, GG; Federico, A; Fontanella, L; Gatti, P; Gentile, I; Longo, A; Masarone, M; Messina, V; Milella, M; Morisco, F; Persico, M; Pierri, P; Rosato, V; Serviddio, G; Sogari, F; Surace, LA; Termite, AP; Terrenato, I; Tundo, P1
Akuta, N; Arase, Y; Fujiyama, S; Hosaka, T; Ikeda, K; Kasuya, K; Kawamura, Y; Kobayashi, M; Kumada, H; Saitoh, S; Sano, T; Sezaki, H; Suzuki, F; Suzuki, Y1
Cooke, G; Fawsitt, CG; Vickerman, P; Welton, NJ1
Antonio Carrión, J; Arenas, J; Arencibia, A; Badia, E; Bernal, V; Buti, M; Cachero, A; Carmona, I; Conde, I; Delgado, M; Diago, M; Esteban, R; Fernández, I; Fernández-Bermejo, M; Fernández-Rodríguez, C; Figueruela, B; García-Samaniego, J; Gea, F; González-Santiago, JM; Hernández-Guerra, M; Iñarrairaegui, M; Lens, S; Llaneras, J; Llerena, S; Luis Calleja, J; María Morillas, R; Mariño, Z; Montoliu, S; Pascasio, JM; Riveiro-Barciela, M; Rosales, JM; Torras, X; Turnes, J1
Arai, T; Asai, A; Asano, T; Atsukawa, M; Fukunishi, S; Hayama, K; Hiraoka, A; Iio, E; Ikeda, H; Ikegami, T; Itokawa, N; Iwakiri, K; Kato, K; Kikuchi, K; Kondo, C; Kumada, T; Matsumoto, N; Matsumoto, Y; Mikami, S; Moriya, A; Nakamuta, M; Nozaki, A; Ogawa, C; Oikawa, T; Okubo, H; Okuse, C; Shimada, N; Tachi, Y; Tada, T; Takaguchi, K; Tanaka, Y; Tani, J; Toyoda, H; Tsubota, A; Tsuruoka, S; Tsutsui, A; Uojima, H; Watanabe, T; Yamashita, N1
Chen, CC; Chen, CH; Chen, DS; Chiu, MC; Fang, YJ; Hsu, SJ; Kao, JH; Kuo, CC; Lee, JY; Yang, TH; Yu, JJ1
Fukuchi, T; Kakizaki, S; Naganuma, A; Namikawa, M; Ohnishi, H; Okamoto, H; Sato, K; Uraoka, T1
Mesgari-Abbasi, M; Mirzakhani, N; Vahdatpour, T; Valizadeh, H1
Burroughs, M; Chayama, K; Eckert, D; Kato, K; Kumada, H; Lin, CW; Liu, W; Mensing, S; Oberoi, RK; Suleiman, AA1
Cotter, TG; Jensen, DM1
Aghemo, A; Asselah, T; Bräu, N; Brown, A; Chen, YJ; Conway, B; Grebely, J; Kleine, H; Lawitz, E; Lei, Y; Mensa, FJ; Negro, F; Pugatch, D; Puoti, M; Welzel, TM1
Chaparro, M; García-Buey, L; Rojo, E1
Chen, B; Chen, K; Li, Y; Shi, H; Wang, Q; Xiao, J; Zhou, Q; Zhou, X1
Bourliere, M1
Ankoma-Sey, V; Bondin, M; Dos Santos, AGP; Elkhashab, M; Fontana, RJ; Lens, S; McPherson, S; Porcalla, A; Trinh, R; Xue, Z; Zeuzem, S1
Agarwal, K; Dore, GJ; Dos Santos, AGP; Feld, JJ; Gane, E; Hezode, C; Kho, D; Klein, M; Lacombe, K; Marks, P; Martinello, M; Matthews, GV; Mercade, GE; Muir, AJ; Müllhaupt, B; Petoumenos, K; Schultz, M; Tatsch, F; Thompson, A; Wedemeyer, H1
Abergel, A; Aguilar, H; Brown, RS; Burroughs, M; Buti, M; Carrion, BR; Chuang, WL; Chulanov, V; Cohen, E; Felizarta, F; Horváth, G; Lin, CW; Lovell, SS; Mensa, FJ; Rodrigues, L; Rodriguez-Perez, F; Schnell, G; Trinh, R; Urbánek, P; Wang, S; Zha, J; Zuckerman, E1
Ferenci, P1
Chen, DS; Chen, PJ; Hsieh, SM; Hung, CC; Kao, JH; Liu, CH; Liu, CJ; Su, TH; Sun, HY; Tseng, TC1
Chayama, K; Gonzalez, YS; Kawaguchi, I; Kumada, H; Mitchell, D; Virabhak, S; Yuen, C1
Aikata, H; Chayama, K; Hiramatsu, A; Imamura, M; Kawaoka, T; Morio, K; Murakami, E; Nakahara, T; Ohya, K; Tsuge, M; Yamauchi, M1
Abunimeh, M; Aglitti, A; Bruchfeld, A; Flisiak, R; Jalundhwala, YJ; Kaskas, M; Lawitz, E; Mensa, FJ; Park, JY; Persico, M; Porcalla, A; Schnell, G; Sise, ME; Wörns, MA; Xue, Z; Zamor, PJ1
Ali, A; Henes, M; Hou, S; Kosovrasti, K; Kurt Yilmaz, N; Leidner, F; Schiffer, CA; Timm, J1
Anderson, M; Caro, L; Chung, C; Fandozzi, C; Fraser, I; Gao, W; Howell, B; Mangin, E; Maxwell, J; Miltenburg, AMM; Popa, S; Railkar, R; Shire, NJ; Stoch, SA; Talal, AH; Van Dyck, K; Webber, AL; Wenning, L1
Chung, RT; Holmes, JA1
Ashraf, A; Kumar, R; Maitra, S; Singh, AD; Singh, N; Tyagi, P1
Abe, H; Akahane, T; Asano, T; Atsukawa, M; Chuma, M; Fujioka, S; Fukunishi, S; Genda, T; Hiraoka, A; Iio, E; Ikeda, H; Ikegami, T; Ishikawa, T; Iwakiri, K; Kumada, T; Masaki, T; Michitaka, K; Mikami, S; Morishita, A; Moriya, A; Nakamuta, M; Nozaki, A; Ogawa, C; Okanoue, T; Okubo, H; Okubo, T; Shima, T; Shimada, N; Tachi, Y; Takaguchi, K; Tanaka, Y; Tani, J; Toyoda, H; Tsubota, A; Tsuji, K; Tsutsui, A; Uojima, H; Watanabe, T; Yamashita, N; Yasuda, S1
Chen, DS; Chen, PJ; Kao, JH; Lin, WT; Liu, CH; Liu, CJ; Peng, CY; Su, TH; Tseng, TC; Yang, SS1
Kakizaki, S; Kizawa, K; Kosone, T; Marubashi, K; Sato, K; Takagi, H; Takakusagi, S; Uraoka, T; Yokoyama, Y1
Kwo, PY; Kwong, AJ1
Kumar, R; Singh, AD1
Kamal, R; Li, Q; Shen, H; Wang, Q; Yu, X; Zhao, ZK1
Angelico, M; Aragri, M; Carioti, L; Ceccherini-Silberstein, F; Di Maio, VC; Lenci, I; Milana, M; Perno, CF; Svicher, V1
Hasegawa, K; Kinoshita, A; Kobayashi, Y; Koike, K; Mizuno, Y; Nakata, R; Ogata, I; Shiraishi, K; Yamada, N; Yasuda, K; Yoshida, H1
Bacon, B; Curry, MP; Dylla, DE; Flamm, SL; Kort, J; Marx, SE; Strezewski, J; Tsai, N; Wick, N1
Chang, TS; Chen, CH; Chen, MY; Chen, WM; Chiu, WN; Hu, JH; Hu, TH; Hung, CH; Lu, CK; Lu, SN; Tung, SY; Wei, KL1
Maasoumy, B; Ohlendorf, V1
Khalil, H; Kim, NG; Kullar, R; Saab, S1
Bernhard, B; Stickel, F1
AlAjmi, MF; Anwar, S; Hassan, MI; Hussain, A; Islam, A; Mohammad, T; Rehman, MT; Shamsi, A1
Fargnoli, A; Gidea, CG; Jacobson, I; Kon, Z; Lewis, T; Lonze, B; Moazami, N; Pavone, J; Qian, Y; Rao, S; Reyentovich, A; Saraon, T; Smith, D1
Abergel, A; Asselah, T; Fredrick, LM; Gane, E; George, C; Hung Le, M; Kowdley, KV; Kwo, PY; Lee, SS; Mensa, F; Nguyen, K; Nguyen, T; Pham, TT; Poordad, F; Schnell, G; Spearman, CW; Wong, F; Yao, BB1
Da, BL; Dieterich, D; Kushner, T; Lourdusamy, V; Saberi, B1
Chen, DS; Chen, PJ; Kao, JH; Liu, CH; Liu, CJ; Su, TH1
Batskikh, SN; Burnevich, EZ; Chulanov, VP; Gusev, DA; Kizlo, SN; Klimova, EA; Krasavina, EN; Mamonova, NA; Samsonov, MY; Tarkhova, EP; Yushchuk, ND; Znoyko, OO1
Caruntu, F; Cohen, S; de Ledinghen, V; Dillon, JF; Dylla, DE; Fredrick, LM; Gschwantler, M; Gutierrez, JA; Muir, AJ; Nevens, F; Pires Dos Santos, AG; Puoti, M; Rodrigues, L; Sigal, S; Slim, J; Zuckerman, E1
Liu, W; Mensa, F; Oberoi, RK; Rosebraugh, M; Wang, H; Zhao, W1
Angel, L; Gidea, C; Kon, Z; Lesko, M; Lewis, TC; Moazami, N; Pavone, J; Reyentovich, A; Smith, DE; Sureau, K1
Alami, NN; Asatryan, A; Burroughs, M; Fredrick, LM; Heo, J; Hou, J; Jia, J; Kalluri, HV; Kim, YJ; Krishnan, P; Lim, SG; Liu, W; Lu, W; Mobashery, N; Tripathi, R; Wang, G; Wei, L; Xie, Q; Xie, W; Zhang, M1
Barclay, ST; Belperio, PS; Bondin, M; Flamm, S; Lampertico, P; Lohmann, K; Marra, F; Marx, S; Mauss, S; Persico, M; Wedemeyer, H; Zhang, Z1
Aragri, M; Arenas Ruiz Tapiador, JI; Cabezas, J; Callegaro, A; Ceccherini-Silberstein, F; Coppola, N; de Salazar, A; di Maio, VC; Dietz, J; Garcia Del Toro, M; García, F; Graf, C; Jimenez, M; Macias Rodriguez, MA; Micheli, V; Müllhaupt, B; Paolucci, S; Pascasio Acevedo, JM; Puoti, M; Rosales Zabal, JM; Sarrazin, C; Stauber, RE; Téllez, F; Vermehren, J1
Chen, YY; Chou, KC; Hsu, YC; Huang, SP; Liu, IL; Su, PY; Wu, SS; Yang, CW; Yen, HH; Zeng, YH1
Rodriguez-Reyes, M; Ruiz-Boy, S; Sotoca-Momblona, JM1
Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; 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Ichijo, T; Joshita, S; Kawakami, F; Kobayashi, H; Nakazawa, H; Sugiura, A; Umemura, T; Wakabayashi, SI; Yamashita, Y; Yamazaki, T1
Aalikhani, M; Alikhani, M; Bazi, Z; Oladnabi, M; Shamsabadi, F1
Ahmed, S; Ajaimy, M; Campbell, A; Graham, JA; Jorde, UP; Nnani, DU; Patel, SR; Saeed, O1
Ekanayake, KB; George, J; Jackson, C; Mahawaththa, MC; Morewood, R; Nitsche, C; Otting, G; Sasi, VM; Shuttleworth, L; Ullrich, S; Whitefield, C; Zhang, X1
Barclay, ST; Burroughs, M; Calleja, JL; de Ledinghen, V; Dylla, DE; Gane, E; Gutierrez, JA; Rizzardini, G; Shiffman, ML; Xue, Z1
Brown, A; Colombo, M; Crown, E; Dillon, JF; Dylla, DE; Feld, JJ; Ghalib, R; Hu, Y; Jacobson, IM; Lawitz, E; Lovell, SS; Luetkemeyer, AF; Moreno, C; Mutimer, D; Nelson, DR; Papatheodoridis, G; Rockstroh, JK; Skoien, R; Zamor, PJ1
Ramos-Guzmán, CA; Ruiz-Pernía, JJ; Tuñón, I1
Ahmad, B; Ain, QU; Batool, M; Choi, S; Kim, MS1
Flamm, SL; Martin, MT; Patel, S1
Macchiagodena, M; Pagliai, M; Procacci, P1
Kakizaki, S; Kanayama, Y; Ohnishi, H; Okamoto, H; Sato, K; Suga, T; Tojima, H; Uehara, D; Uraoka, T; Yamazaki, Y; Yanagisawa, K1
Beier, C; Cornberg, M; Kordecki, N; Maasoumy, B; Ohlendorf, V; Sandmann, L; Tergast, TL; Wedemeyer, H1
Feng, BL; Li, JM; Luo, JW; Naidoo, N; Wang, P; Wu, G; Xie, YX; Zhou, HJ1
Duan, Y; Fang, C; Feng, L; Ma, D; Peng, C; Rao, Z; Shao, M; Wang, H; Yang, H; Yang, K; Yang, X; Zhang, L; Zhang, Q; Zhang, R; Zhao, J; Zhao, X; Zhao, Y; Zhu, Y1
Karrenbrock, M; Macchiagodena, M; Pagliai, M; Procacci, P1
Allerton, CMN; Anderson, AS; Aschenbrenner, L; Avery, M; Berritt, S; Boras, B; Cardin, RD; Carlo, A; Coffman, KJ; Dantonio, A; Di, L; Eng, H; Ferre, R; Gajiwala, KS; Gibson, SA; Greasley, SE; Hurst, BL; Kadar, EP; Kalgutkar, AS; Lee, J; Lee, JC; Liu, W; Mason, SW; Noell, S; Novak, JJ; Obach, RS; Ogilvie, K; Owen, DR; Patel, NC; Pettersson, M; Rai, DK; Reese, MR; Sammons, MF; Sathish, JG; Singh, RSP; Steppan, CM; Stewart, AE; Tuttle, JB; Updyke, L; Verhoest, PR; Wei, L; Yang, Q; Zhu, Y1
Abbas, SN; Bhatti, S; Mahmood, N; Nasir, SB; Shahid, S1
Couzin-Frankel, J1
Bair, MJ; Chang, CC; Chang, TS; Chen, CT; Chen, CY; Chen, GY; Cheng, CY; Cheng, PN; Chong, LW; Chuang, WL; Dai, CY; Hsieh, TY; Hu, JT; Huang, CF; Huang, CS; Huang, CW; Huang, JF; Huang, YH; Hung, CH; Kao, CN; Kao, JH; Kuo, HT; Lee, MH; Lee, PL; Lee, TH; Lin, CL; Lin, HC; Liu, CJ; Lo, CC; Mo, LR; Peng, CY; Su, WW; Tai, CM; Tsai, PC; Tseng, KC; Wang, CC; Wang, SJ; Wu, WC; Yang, CC; Yang, SS; Yeh, ML; Yu, ML1
Hachisu, Y; Hatanaka, T; Hazama, Y; Kaburagi, T; Kakizaki, S; Kashiwabara, K; Murata, K; Naganuma, A; Nagashima, S; Nakano, S; Nishizawa, T; Okamoto, H; Saito, N; Takahashi, M; Tanaka, Y; Uraoka, T; Yamazaki, Y; Yoshida, S; Yoshinaga, T1
Wang, Z; Yang, L1
Parums, DV2
Davies, GW; Heskin, J; Jones, R; Moore, LSP; Mughal, N; Pallett, SJC; Rayment, M1
Borio, LL; Bright, RA; Emanuel, EJ1
Drożdżal, S; Ghavami, S; Kotfis, K; Lechowicz, K; Lorzadeh, S; Machaj, F; Przybyciński, J; Rosik, J; Szostak, B; Łos, MJ1
Fetta, S; Kontoghiorghe, CN; Kontoghiorghes, GJ1
Del Rio, C; Gandhi, RT; Malani, PN1
Fishbane, S; Hirsch, JS; Nair, V1
Li, J; Liu, J; Ma, HX; Wang, CY; Wen, J1
Misra, A; Singh, A; Singh, AK; Singh, R1
Kozlov, M1
André, E; Chiu, W; De Jonghe, S; Jochmans, D; Leyssen, P; Maes, P; Neyts, J; Raymenants, J; Slechten, B; Vangeel, L1
Alexander, G; Alric, L; Busch, MP; Carrington, M; Chung, RT; Cox, AL; Cramp, ME; Donfield, SM; Douillard, V; Duggal, P; Edlin, BR; Goedert, JJ; Gourraud, PA; Grifoni, A; Johnson, EO; Khakoo, SI; Kim, AY; Kirk, GD; Kral, AH; Lauer, GM; Mangia, A; Mehta, SH; Murphy, EL; Piazzolla, V; Price, JC; Rosen, HR; Sette, A; Thio, CL; Thomas, DL; Valencia, A; Vergara, C; Vince, N; Wojcik, GL1
Bowman, CJ; Campion, SN; Cappon, GD; Catlin, NR; Cheung, JR; Nowland, WS; Sathish, JG; Stethem, CM; Updyke, L1
Bajaj, SS; Stanford, FC1
Bansal, S; Giacomet, V; Hsueh, CH; Indolfi, G; Iorio, R; Kelly, D; Kersey, K; Mangia, A; Mania, A; Nebbia, G; Parhy, B; Pawlowska, M; Sang Yue, M; Shao, J; Szenborn, L1
Lee, TC; McDonald, EG1
Chen, C; Cheng, Y; Feng, Z; Mao, Q; Tang, J; Wang, C; Wang, M; Wen, W; Wu, Q; Zhang, X; Zhou, M; Zhou, X1
Hidaka, Y; Inadome, A; Kaba, A; Kashima, M; Miyata, A; Takekuma, Y; Toyoda, M; Yamanaga, S; Yokomizo, H1
Martin, MT; Naveed, A; Waring, N1
Boras, B; Dantonio, AL; Di, L; Eng, H; Kadar, EP; Kalgutkar, AS; Kimoto, E; Lin, J; Novak, JJ; Obach, RS; Patel, NC; Singh, RSP; Walker, GS1
Abdelnabi, R; Augustijns, P; Chatelain, E; De Jonghe, S; Escudié, F; Foo, CS; Hoglund, RM; Jochmans, D; Mols, R; Mowbray, CE; Neyts, J; Scandale, I; Sjö, P; Tarning, J; Vangeel, L; Wattanakul, T; Weynand, B1
Abreu, P; Baniecki, M; Bao, W; Damle, B; Gardner, A; Hammond, J; Hendrick, VM; Leister-Tebbe, H; Pypstra, R; Rusnak, JM; Simón-Campos, A; Wisemandle, W1
Baden, LR; Morrissey, S; Rubin, EJ1
Ekanayake, KB; Nitsche, C; Otting, G; Ullrich, S1
Iglesias, C; Reina, J1
Ali, A; Chan, ET; Hedger, AK; Henes, M; Kosovrasti, K; Kurt Yilmaz, N; Matthew, AN; Nageswara Rao, D; Schiffer, CA; Timm, J; Vo, SV; Zephyr, J1
Usher, AD1
Agarwal, K; Burroughs, M; Felizarta, F; Gane, E; Hassanein, T; Krishnan, P; Nevens, F; Overcash, JS; Poordad, F; Shaw, D; Topp, A; Waters, M; Yao, BB1
Ledford, H1
Camus, G; Grant, PM; Gupta, N; Kabihizi, J; Kateera, F; Makuza, JD; Manirambona, L; Mukabatsinda, C; Murangwa, A; Musabeyezu, E; Muvunyi, CM; Nsanzimana, S; Serumondo, J; Shumbusho, F1
Brown, RS; Chen, JK; Hedvat, J; Jennings, DL; Kovac, DB; Lange, NW; Pereira, MR; Salerno, DM; Scheffert, J; Shertel, T1
Almond, LM; Beringer, PM; Chung, PS; Hong, E; Rao, AP1
Foerster, KI; Haefeli, WE; Mikus, G; Said, A; Schulz, M; Terstegen, T; Vogt, C1
Christensen, PB; Dröse, S; Hansen, JF; Holm, DK; Madsen, LW; Røge, BT; Øvrehus, A1
Ledford, H; Maxmen, A1
Allen, R; Anderson, AS; Bergman, A; Binks, M; Chan, PL; Clark, F; Hackman, F; Kadar, EP; Menon, S; Nucci, G; Pawlak, S; Rao, R; Shi, H; Singh, RSP; Toussi, SS; Van Eyck, L1
Fan, X; Fu, R; Fu, Y; Jiang, H; Li, J; Lin, C; McCormick, PJ; Yang, Y; Yu, B; Zeng, P; Zhang, J; Zhang, Y; Zhong, F; Zhou, X1
Extance, A1
Costacurta, F; Geley, S; Harris, RS; Heilmann, E; Mogadashi, SA; Rupp, B; Volland, A; von Laer, D1
Cherrington, NJ; Hau, RK; Wright, SH1
Ando, H; Atsukawa, M; Ikejima, K; Nagahara, A; Nakadera, E; Okubo, H; Okubo, T1
Adachi, E; Chong, Z; Diamond, MS; Douek, DC; Duong, C; Fujisaki, S; Furusawa, Y; Godbole, S; Gordon, A; Hagihara, M; Halfmann, PJ; Hasegawa, H; Hattori, SI; Hojo, M; Iida, S; Imai, M; Ito, M; Iwatsuki-Horimoto, K; Kawaoka, Y; Kiso, M; Koga, M; Kuroda, M; Larson, D; Li, R; Liu, Y; Loeber, S; Maeda, K; Maemura, T; Mitamura, K; Mitsuya, H; Murakami, J; Ohmagari, N; Okuda, M; Ozono, S; Saito, M; Sakai-Tagawa, Y; Sato, T; Suzuki, T; Takashita, E; Tsutsumi, T; Ueki, H; Ujie, M; Uraki, R; Valdez, R; Wang, Z; Watanabe, S; Wright, R; Yamamoto, S; Yamayoshi, S; Yasuhara, A; Yotsuyanagi, H1
Chen, JJ; Cheng, PN; Chien, SC; Chiu, HC; Chiu, YC; Lee, PL; Tung, HD1
Li, S; Lyu, G; Yang, H; Yang, Y1
Burki, T1
Bartha, FA; Han, R; Juhász, N; Marzban, S; Röst, G1
Alvarado, YJ; González-Paz, L; Hurtado-León, ML; Jeffreys, LN; Loroño, M; Lossada, C; Olivarez, Y; Paz, JL; Torres, FJ; Vera, E; Vera-Villalobos, J; Vivas, A1
Anjum Zia, M; Jahan, N; Kiran, S; Mujtaba, N; Naqvi, SAR; Sultana, B1
Phizackerley, D1
Rubin, R1
Collado, A; Corma-Gomez, A; Cucurull, J; Gonzalez-Serna, A; Granados, R; Hernandez-Quero, J; Macias, J; Merino, D; Palacios, R; Pineda, JA; Real, LM; Rios, MJ; Rivero-Juarez, A; Tellez, F1
Chan, ECY; Wang, Z1
Hui, VK; Kao, JH; Kumar, R; Liu, CH; Tan, J; Tan, SS; Thurairajah, PH; Wong, GH; Wong, YJ1
Ackerson, BK; Hong, V; Lewin, BJ; Lewnard, JA; Lipsitch, M; Malden, DE; Tartof, SY1
Falade-Nwulia, O; Karimi-Sari, H; Lim, JK; Rezaee-Zavareh, MS1
Tanne, JH1
Chuang, WL; Dai, CY; Huang, CF; Huang, JF; Yu, ML1
Berar Yanay, N; Bogner, I; Saker, K; Tannous, E1
Azanza, JR; Barberán, J; González Del Castillo, J; Linares Rufo, M; Madero Valle, N; Mensa, J; Molero, JM1
Kesari, S; Kouznetsova, VL; Tsigelny, IF; Yerabandi, N1
Allen, R; Alugubelli, YR; Blankenship, LR; Cho, CC; Geng, ZZ; Ji, H; Khatua, K; Li, P; Liu, WR; Ma, XR; Ma, Y; Sankaran, B; Shaabani, N; Vatansever, EC; Xiao, J; Xu, S; Yang, KS; Yu, G1
Gao, Y; Lin, Y; Sun, F; Wang, X; Ye, S1
Bahmanyar, M; Marzi, M; Vakil, MK; Zarenezhad, E1
Chen, SF; Joerger, T; Kushner, LE; Lee, J; Profita, E; Puckett, L1
Service, RF1
Anderson, AS; Cardin, R; Gribenko, A; Hao, L; Lee, JT; Liberator, PA; Perrin, BS; Yang, Q; Zhu, Y1
Kuehn, BM1
Cornberg, M; Hidde, D; Klinker, H; Lohmann, K; Lutz, T; Möller, H; Naumann, U; Simon, KG; Stoehr, A; Teuber, G1
Altwegg, KA; Chakravarty, D; Chen, Y; Ebrahimi, B; Huang, TH; Krishnan, S; Lai, Z; Li, X; Liu, J; Liu, Z; Ma, S; Mann, M; McHardy, S; Park, BH; Pratap, UP; Raj, GV; Rao, MK; Sanchez, JR; Santhamma, B; Sareddy, GR; Tekmal, RR; Vadlamudi, RK; Vankayalapati, H; Viswanadhapalli, S; Yuan, Y; Zhou, D1
Liang, L; Wang, X; Yin, W1
Chang, KC; Chang, TS; Chen, CH; Chen, WM; Chen, YH; Hsieh, YY; Hung, CH; Lu, CK; Lu, SN; Lu, YH; Tung, SY; Tung, WL; Yen, CW1
Chen, X; Feng, L; Wang, Y; Xiao, W; Zhao, D1
Arbel, R; Balicer, R; Battat, E; Ben-Shlomo, Y; Dagan, N; Friger, M; Hammerman, A; Hoshen, M; Lavie, G; Netzer, D; Peretz, A; Serby, D; Sergienko, R; Waxman, JG; Wolff Sagy, Y; Yaron, S1
Barclay, ST; Bradley-Stewart, A; Davis, C; Filipe, A; Fox, R; Gunson, R; MacLean, A; Ngan Chiu Bong, M; Peters, ES; Shah, R; Shepherd, SJ; Thomson, EC; Tong, L; van Vliet, VJE1
Juárez-López, D; Schcolnik-Cabrera, A1
Larkin, HD2
Bhattacharya, A; Chauhan, P; Dwivedi, A; Mishra, A; Pandey, S1
Anderson, AS; Caubel, P; Rusnak, JM1
Adams, E; Charness, ME; Gupta, K; Ho, DD; Lindy, DC; Mohri, H; Stack, G; Strymish, J1
Chen, TC; Cheng, TL; Huang, BC; Li, CC; Liao, JM; Lin, WW; Wang, YT1
Rosenberg, K1
Bhat, IA; Bhat, RAH; Dash, P; Ganie, PA; Gargotra, P; Nazir, MI; Siva, C; Tandel, RS; Yousuf, DJ1
Lafree, A; Navarro, MR; Nene, RV; Tomaszewski, CA1
Ding, T; Gao, L; Ge, J; Gu, Q; Ma, X; Shen, W; Wang, H; Xue, F; Zhang, X1
Ma, X; Wei, Y; Yang, Z; Zhang, W; Zhou, F1
Chen, JY; He, Y; Li, YJ; Liu, CH; Lu, Y; Song, ZJ; Wang, YL; Zhu, XQ1
Gu, Y; Qiang, W; Sun, Y; Wu, R; Yin, T; Yuan, J1
Bai, Y; Chen, Y; Cheng, B; Liu, Y; Xu, S; Yang, X1
Li, MH; Qiu, FW; Shen, G; Shi, XL1
Brayden, DJ; Byrne, HJ; Frías, JM; Gleeson, JP; Khalid Danish, M; Ryan, SM1
Hu, Q; Hua, C; Huo, G; Jiang, H; Li, S; Wu, Y; Zhou, F; Zhu, H1
Decker, AP; Mechesso, AF; Wang, G1
Ban, Q; Hou, YY; Huang, T; Ma, B; Shi, L; Zhang, ML; Zhang, Q; Zhou, YF1
He, X; Li, X; Liu, M; Sun, T; Wang, X1
Bian, Q; Chavez, A; Culbertson, B; Duan, Y; Goff, SP; Ho, DD; Hong, SJ; Iketani, S; Lin, M; Liu, X; Lu, Y; Luck, MI; Mohri, H; Rao, Z; Sabo, Y; Sun, H; Wang, H; Yang, H; Yang, K; Yang, X; Zhang, X; Zhou, H; Zhu, Y1
Chen, M; Han, M; Meng, X; Wang, S; Wang, Z; Wu, R; Yang, Y; Zhang, J; Zhang, Y; Zhao, Q1
Cozzolino, L; Hubbard, PC; McQuaid, CD; Nicastro, KR; Seuront, L; Zardi, GI1

Reviews

66 review(s) available for proline and leucine

ArticleYear
Molecular genetics and transgenic model of Gertsmann-Sträussler-Scheinker disease.
    Alzheimer disease and associated disorders, 1991,Fall, Volume: 5, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Codon; Genetic Markers; Gerstmann-Straussler-Scheinker Disease; Humans; Leucine; Mice; Mice, Transgenic; Models, Genetic; Prions; Proline; PrPSc Proteins

1991
The practice and application of electron microscope autoradiography.
    International review of cytology, 1971, Volume: 30

    Topics: Animals; Autoradiography; Bacillus subtilis; Carbohydrates; Carbon Isotopes; DNA; Emulsions; Escherichia coli; Guinea Pigs; Histocytochemistry; Histological Techniques; L Cells; Leucine; Lipids; Mathematics; Mice; Microscopy, Electron; Microtomy; Neoplasms; Pancreas; Paramecium; Photomicrography; Plants; Proline; Proteins; Radiation Effects; Radioisotopes; Rats; RNA; Staining and Labeling; Sulfur Isotopes; Thymidine; Thyroid Gland; Time Factors; Tritium; Triturus; Viruses; Xenopus

1971
A review of biochemical studies on the genetically distinct collagens of the skeletal system.
    Clinical orthopaedics and related research, 1973, Issue:92

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Bone and Bones; Cartilage, Articular; Collagen; Glutamates; Homoserine; Hydroxyproline; Leucine; Peptides; Phenylalanine; Proline; Rats; Serine; Threonine; Valine

1973
Utilization of D- and DL- amino acids and analogs.
    Poultry science, 1972, Volume: 51, Issue:1

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chickens; Cystine; Histidine; Isomerism; Keto Acids; Leucine; Methionine; Nutritional Requirements; Phenylalanine; Proline; Rats; Serine; Threonine; Tryptophan; Tyrosine; Valine

1972
Genetics of amino acid transport in bacteria.
    Annual review of genetics, 1974, Volume: 8

    Topics: Alanine; Amino Acids; Amino Acids, Diamino; Arginine; Asparagine; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Cystine; Energy Metabolism; Escherichia coli; Genes, Regulator; Genetics, Microbial; Glutamates; Glutamine; Glycine; Histidine; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1974
Influence of elevated circulating levels of amino acids on cerebral concentrations and utilization of amino acids.
    Progress in brain research, 1968, Volume: 29

    Topics: Amino Acids; Animals; Biological Transport, Active; Carbon Isotopes; Cerebral Cortex; Fasting; Injections, Intravenous; Leucine; Male; Phenylalanine; Proline; Rats; Time Factors; Valine

1968
Regulation of skeletal growth by sulfation factor.
    Advances in internal medicine, 1971, Volume: 17

    Topics: Acromegaly; Bone and Bones; Bone Development; Cartilage; Chondroitin; DNA; Dwarfism, Pituitary; Growth Hormone; Humans; Hydrocortisone; Hydroxyproline; Hypophysectomy; Insulin; Leucine; Proline; RNA; Somatomedins; Sulfates; Testosterone

1971
Amino acid degradation by anaerobic bacteria.
    Annual review of biochemistry, 1981, Volume: 50

    Topics: Amino Acids; Anaerobiosis; Aspartic Acid; Clostridium; Culture Media; Glutamates; Glycine; Isoleucine; Leucine; Lysine; Ornithine; Phenylalanine; Proline; Species Specificity; Threonine; Tryptophan; Tyrosine; Valine

1981
An inherited prion disease with a PrP P105L mutation: clinicopathologic and PrP heterogeneity.
    Neurology, 1999, Jul-13, Volume: 53, Issue:1

    Topics: Amino Acid Substitution; Brain; Codon; Female; Humans; Leucine; Male; Methionine; Middle Aged; Mutation, Missense; Nuclear Family; Pedigree; Polymorphism, Genetic; Prion Diseases; Prions; Proline; Valine

1999
R3531C mutation in the apolipoprotein B gene is not sufficient to cause hypercholesterolemia.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:10

    Topics: Adolescent; Adult; Aged; Apolipoproteins B; Child; Child, Preschool; Cholesterol, LDL; Female; Haplotypes; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Leucine; Lod Score; Male; Middle Aged; Mutation; Nuclear Family; Pedigree; Polymorphism, Restriction Fragment Length; Proline; Receptors, LDL

2000
Laminopathies affecting skeletal and cardiac muscles: clinical and pathophysiological aspects.
    Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2005, Volume: 24, Issue:2

    Topics: Animals; Cardiomyopathy, Dilated; Disease Models, Animal; Humans; Lamin Type A; Lamins; Leucine; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophy, Emery-Dreifuss; Myocardium; Nuclear Envelope; Proline

2005
Emerging therapeutic options in hepatitis C virus infection.
    The American journal of managed care, 2011, Volume: 17 Suppl 4

    Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication

2011
Second-wave protease inhibitors: choosing an heir.
    Clinics in liver disease, 2011, Volume: 15, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins

2011
Hepatitis C direct-acting antiviral agents: changing the paradigm of hepatitis C treatment in HIV-infected patients.
    Journal of clinical gastroenterology, 2014, Volume: 48, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Coinfection; Hepatitis C; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferons; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins

2014
Faldaprevir (BI 201335) for the treatment of hepatitis C in patients co-infected with HIV.
    Expert review of anti-infective therapy, 2014, Volume: 12, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Availability; Clinical Trials as Topic; Coinfection; Drug Administration Schedule; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Virus Replication

2014
Management of HCV patients with cirrhosis with direct acting antivirals.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1

    Topics: Algorithms; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Liver Cirrhosis; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate

2014
Treating HCV in HIV 2013: on the cusp of change.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine

2014
Second-wave IFN-based triple therapy for HCV genotype 1 infection: simeprevir, faldaprevir and sofosbuvir.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate

2014
HCV direct-acting antiviral agents: the best interferon-free combinations.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials as Topic; Disease Eradication; Drug Discovery; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon-alpha; Isoquinolines; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pyrrolidines; Quinolines; Recombinant Proteins; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine; Viral Nonstructural Proteins; Virus Replication

2014
HCV F1/F2 patients: treat now or continue to wait.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Treatment Outcome; Uridine Monophosphate

2014
Hepatitis C virus therapy in the direct acting antiviral era.
    Current opinion in gastroenterology, 2014, Volume: 30, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Sofosbuvir; Thiazoles; Uridine Monophosphate

2014
Faldaprevir for the treatment of genotype-1 hepatitis C virus.
    Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Ribavirin; Thiazoles

2015
Faldaprevir for the treatment of hepatitis C.
    International journal of molecular sciences, 2015, Mar-04, Volume: 16, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Thiazoles; Viral Nonstructural Proteins

2015
Faldaprevir for the treatment of hepatitis C.
    Drugs of today (Barcelona, Spain : 1998), 2015, Volume: 51, Issue:5

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Discovery; Drug Interactions; Hepatitis C; Humans; Leucine; Molecular Structure; Oligopeptides; Proline; Quinolines; Thiazoles; Tissue Distribution; Treatment Outcome; Viral Nonstructural Proteins

2015
[Preclinical and clinical properties of vaniprevir (VANIHEP® Capsules 150 mg), a novel therapeutic agent for hepatitis C].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2015, Volume: 146, Issue:3

    Topics: Antiviral Agents; Capsules; Clinical Trials as Topic; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Sulfonamides

2015
Mutational scanning of the CHCHD2 gene in Han Chinese patients with Parkinson's disease and meta-analysis of the literature.
    Parkinsonism & related disorders, 2016, Volume: 29

    Topics: Adult; Aged; Asian People; DNA Mutational Analysis; DNA-Binding Proteins; Genetic Association Studies; Genotype; Humans; Leucine; Middle Aged; Mitochondrial Proteins; Mutation; Parkinson Disease; Proline; Transcription Factors

2016
The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism.
    Advances in nutrition (Bethesda, Md.), 2016, Volume: 7, Issue:4

    Topics: Amino Acids; Animals; Astrocytes; Blood Glucose; Dietary Fats; Gluconeogenesis; Glucose; Glycogenolysis; Homeostasis; Humans; Hypothalamus; Leucine; Liver; Neurons; Proline; Vagus Nerve

2016
HCV management in resource-constrained countries.
    Hepatology international, 2017, Volume: 11, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Carbamates; Continuity of Patient Care; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Drugs, Generic; Fluorenes; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Risk Factors; Sofosbuvir; Sulfonamides; Valine

2017
Sofosbuvir, velpatasvir and voxilaprevir combination for the treatment of hepatitis C.
    Expert review of gastroenterology & hepatology, 2017, Volume: 11, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2017
Evaluation of sofosbuvir, velpatasvir plus voxilaprevir as fixed-dose co-formulation for treating hepatitis C.
    Expert opinion on drug metabolism & toxicology, 2017, Volume: 13, Issue:9

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Interactions; Drug Resistance, Viral; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Tablets; Treatment Outcome

2017
Glecaprevir/Pibrentasvir: First Global Approval.
    Drugs, 2017, Volume: 77, Issue:16

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Approval; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; United States; United States Food and Drug Administration; Viral Nonstructural Proteins

2017
Sofosbuvir/Velpatasvir/Voxilaprevir: A Pan-Genotypic Direct-Acting Antiviral Combination for Hepatitis C.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2018
Glecaprevir + pibrentasvir (ABT493 + ABT-530) for the treatment of Hepatitis C.
    Expert review of gastroenterology & hepatology, 2018, Volume: 12, Issue:1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Combinations; Enzyme Inhibitors; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins

2018
Glecaprevir + pibrentasvir for treatment of hepatitis C.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Half-Life; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome

2018
Sofosbuvir/Velpatasvir/Voxilaprevir: A Review in Chronic Hepatitis C.
    Drugs, 2018, Volume: 78, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Approval; Drug Combinations; Drug Resistance, Viral; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; United States; United States Food and Drug Administration; Viral Nonstructural Proteins

2018
Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy.
    Hepatology international, 2018, Volume: 12, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Costs; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides

2018
Sofosbuvir, velpatasvir and voxilaprevir combination therapy for treating patients with hepatitis C virus infection.
    Drugs of today (Barcelona, Spain : 1998), 2018, Volume: 54, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome

2018
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection in adults.
    Drugs of today (Barcelona, Spain : 1998), 2018, Volume: 54, Issue:7

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Clinical Trials as Topic; Cyclopropanes; Drug Combinations; Drug Interactions; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2018
Sofosbuvir/velpatasvir/voxilaprevir: a highly effective option for retreatment of hepatitis C in difficult-to-treat patients.
    Antiviral therapy, 2019, Volume: 24, Issue:1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2019
Review article: novel antivirals for hepatitis C-sofosbuvir/velpatasvir/voxilaprevir, glecaprevir/pibrentasvir.
    Alimentary pharmacology & therapeutics, 2018, Volume: 48, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Clinical Trials, Phase III as Topic; Cyclopropanes; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides

2018
Managing hepatitis C therapy failures and chronic kidney disease.
    Expert review of clinical pharmacology, 2018, Volume: 11, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Cardiovascular Diseases; Cyclopropanes; Drug Combinations; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Sulfonamides; Treatment Failure

2018
Expert opinion on the management of renal manifestations of chronic HCV infection.
    Antiviral therapy, 2018, Volume: 23, Issue:Suppl 2

    Topics: 2-Naphthylamine; Amides; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Benzofurans; Carbamates; Cyclopropanes; Disease Management; Drug Therapy, Combination; Expert Testimony; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Practice Guidelines as Topic; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Risk Factors; Ritonavir; Sulfonamides; Uracil; Valine

2018
Treatment of hepatitis C virus genotype 4 in the DAA era.
    Virology journal, 2018, 11-22, Volume: 15, Issue:1

    Topics: Aminoisobutyric Acids; Anilides; Antiviral Agents; Carbamates; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Interferons; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Valine

2018
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection.
    Future microbiology, 2019, Volume: 14

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Coinfection; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Fibrosis; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Sulfonamides; Treatment Outcome

2019
Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants.
    Hepatology (Baltimore, Md.), 2019, Volume: 70, Issue:3

    Topics: 2-Naphthylamine; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Denmark; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Prognosis; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Uracil; Valine

2019
Upcoming direct acting antivirals for hepatitis C patients with a prior treatment failure.
    Clinical and molecular hepatology, 2019, Volume: 25, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Proline; Quinoxalines; Randomized Controlled Trials as Topic; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure

2019
Successful treatment of chronic hepatitis C virus infection with crushed glecaprevir/pibrentasvir administered via a percutaneous endoscopic gastrostomy tube: case report and review of the literature.
    Clinical journal of gastroenterology, 2019, Volume: 12, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Administration Routes; Drug Therapy, Combination; Female; Gastrostomy; Hepatitis C, Chronic; Humans; Intubation, Gastrointestinal; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2019
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Design; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Microbial Sensitivity Tests; Molecular Conformation; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2019
Adherence to pan-genotypic glecaprevir/pibrentasvir and efficacy in HCV-infected patients: A pooled analysis of clinical trials.
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
New approaches in viraemic organ transplantation and antiviral therapies.
    Nature reviews. Gastroenterology & hepatology, 2020, Volume: 17, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Guanine; Hepatitis B, Chronic; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Liver Transplantation; Macrocyclic Compounds; Proline; Quinoxalines; Salvage Therapy; Sofosbuvir; Sulfonamides; Tenofovir; Transplants

2020
Systematic review with meta-analysis: impact of baseline resistance-associated substitutions on the efficacy of glecaprevir/pibrentasvir among chronic hepatitis C patients.
    Alimentary pharmacology & therapeutics, 2020, Volume: 51, Issue:5

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Non-Randomized Controlled Trials as Topic; Proline; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Viral Nonstructural Proteins

2020
Meeting the WHO hepatitis C virus elimination goal: Review of treatment in paediatrics.
    Journal of viral hepatitis, 2020, Volume: 27, Issue:8

    Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Child; Child, Preschool; Cyclopropanes; Disease Eradication; Drug Therapy, Combination; Fluorenes; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Pediatrics; Proline; Pyrrolidines; Quality of Life; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; World Health Organization

2020
Eight Weeks of Treatment With Glecaprevir/Pibrentasvir Is Safe and Efficacious in an Integrated Analysis of Treatment-Naïve Patients With Hepatitis C Virus Infection.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020, Volume: 18, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Real-World Clinical Practice Use of 8-Week Glecaprevir/Pibrentasvir in Treatment-Naïve Patients with Compensated Cirrhosis.
    Advances in therapy, 2020, Volume: 37, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Genetic Variation; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea

2022
Effect of baseline resistance-associated substitutions on the efficiency of glecaprevir/pibrentasvir in chronic hepatitis C subjects: A meta-analysis.
    Journal of viral hepatitis, 2021, Volume: 28, Issue:1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Glecaprevir/pibrentasvir ultra-short treatment to cure HCV infection: case report and literature review.
    Le infezioni in medicina, 2020, Dec-01, Volume: 28, Issue:4

    Topics: Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Efficacy and Safety of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C: A Pooled Analysis of Five Phase II/III Trials.
    Gut and liver, 2021, 11-15, Volume: 15, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Republic of Korea; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2021
Successful treatment by glecaprevir/pibrentasvir followed by hepatoprotective therapy of acute chronic hepatitis exacerbation caused by daratumumab-based regimen for multiple myeloma: Case report and review of the literature.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2021, Volume: 27, Issue:12

    Topics: Aged; Aminoisobutyric Acids; Antibodies, Monoclonal; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Multiple Myeloma; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment.
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2021, Volume: 59

    Topics: Adult; Antiviral Agents; COVID-19; COVID-19 Serotherapy; Humans; Immunization, Passive; Lactams; Leucine; Nitriles; Pandemics; Pharmaceutical Preparations; Proline; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome

2021
The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic.
    Frontiers in bioscience (Landmark edition), 2021, 12-30, Volume: 26, Issue:12

    Topics: Antiviral Agents; COVID-19; Drug Delivery Systems; Humans; Lactams; Leucine; Nitriles; Pandemics; Proline; SARS-CoV-2

2021
Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19:a meta-analysis.
    Annals of medicine, 2022, Volume: 54, Issue:1

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Fluvoxamine; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
[Nirmatrelvir plus ritonavir (Paxlovid) a potent SARS-CoV-2 3CLpro protease inhibitor combination].
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2022, Volume: 35, Issue:3

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Indoles; Lactams; Leucine; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; Pyrrolidinones; Ritonavir; SARS-CoV-2

2022
The role of BAG3 in dilated cardiomyopathy and its association with Charcot-Marie-Tooth disease type 2.
    Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2022, Volume: 41, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Cardiomyopathy, Dilated; Charcot-Marie-Tooth Disease; Humans; Leucine; Proline; Protein Aggregates

2022
Paxlovid: Mechanism of Action, Synthesis, and
    BioMed research international, 2022, Volume: 2022

    Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19 Drug Treatment; COVID-19 Vaccines; Cysteine Endopeptidases; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Pandemics; Proline; Protease Inhibitors; Ritonavir; SARS-CoV-2; Viral Nonstructural Proteins

2022
Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer.
    Cellular oncology (Dordrecht), 2022, Volume: 45, Issue:5

    Topics: Amino Acids; Arginine; Carbohydrates; Glutamine; Humans; Leucine; Lipids; Male; Proline; Prostatic Neoplasms; Sarcosine; Serine; TOR Serine-Threonine Kinases

2022

Trials

115 trial(s) available for proline and leucine

ArticleYear
Plasma proline and leucine kinetics: response to 4 wk with proline-free diets in young adults.
    The American journal of clinical nutrition, 1994, Volume: 60, Issue:2

    Topics: Adult; Amino Acids; Caproates; Dietary Proteins; Humans; Infusions, Intravenous; Keto Acids; Leucine; Male; Proline; Single-Blind Method

1994
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.
    Nature medicine, 1998, Volume: 4, Issue:12

    Topics: Adult; Aged; Alleles; Amino Acid Substitution; Cholesterol; Cholesterol, LDL; Female; Gene Frequency; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Proline; Protein Sorting Signals

1998
Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal.
    American journal of physiology. Endocrinology and metabolism, 2001, Volume: 280, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Burns; Carbon Isotopes; Deuterium; Female; Humans; Kinetics; Leucine; Male; Middle Aged; Nitrogen Isotopes; Ornithine; Oxidation-Reduction; Parenteral Nutrition, Total; Proline

2001
Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women.
    Bone, 2004, Volume: 35, Issue:3

    Topics: Bone Density; Estrogen Replacement Therapy; Female; Femur Neck; Follow-Up Studies; Humans; Leucine; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Postmenopause; Proline; Protein Precursors; Protein Sorting Signals

2004
Adaptation to a long term (4 weeks) arginine- and precursor (glutamate, proline and aspartate)-free diet.
    Clinical nutrition (Edinburgh, Scotland), 2008, Volume: 27, Issue:4

    Topics: Adult; Analysis of Variance; Arginine; Aspartic Acid; Carbon Isotopes; Citrulline; Diet; Dietary Proteins; Female; Glutamic Acid; Homeostasis; Humans; Infusions, Intravenous; Isotope Labeling; Kinetics; Leucine; Male; Nitrogen Isotopes; Oxidation-Reduction; Proline; Time Factors; Urea

2008
Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:5

    Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Dipeptides; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inpatients; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Outpatients; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ritonavir; RNA, Viral; Sulfones; Urea; Young Adult

2010
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection.
    Journal of hepatology, 2011, Volume: 54, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Load; Viral Nonstructural Proteins

2011
A new protocol for the treatment of the chronic venous ulcers of the lower limb.
    Clinical and experimental medicine, 2012, Volume: 12, Issue:1

    Topics: Administration, Topical; Adolescent; Adult; Aged; Alginates; Cellulose; Chronic Disease; Compression Bandages; Female; Gels; Glucuronic Acid; Glycine; Hexuronic Acids; Humans; Hyaluronic Acid; Leucine; Lower Extremity; Lysine; Male; Middle Aged; Proline; Prospective Studies; Time Factors; Treatment Outcome; Varicose Ulcer; Wound Healing; Young Adult

2012
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection.
    Gastroenterology, 2011, Volume: 141, Issue:6

    Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Thiazoles; Treatment Outcome; Viral Load; Viral Nonstructural Proteins

2011
PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.
    Journal of nutrigenetics and nutrigenomics, 2011, Volume: 4, Issue:6

    Topics: Adult; Aged; Alanine; Amino Acid Substitution; Dietary Fats; Eating; Female; Gene-Environment Interaction; Genetic Association Studies; Humans; Leucine; Lipids; Male; Middle Aged; Mutation, Missense; Osmolar Concentration; Polymorphism, Single Nucleotide; PPAR alpha; PPAR gamma; Proline; Valine

2011
Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: a randomized phase II study.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:3

    Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Sulfonamides; Young Adult

2012
Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Nonstructural Proteins

2013
A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment.
    Journal of hepatology, 2013, Volume: 59, Issue:1

    Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Young Adult

2013
Sustained virologic response after therapy with the HCV protease inhibitor narlaprevir in combination with peginterferon and ribavirin is durable through long-term follow-up.
    Journal of viral hepatitis, 2013, Volume: 20, Issue:4

    Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Dipeptides; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Placebos; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Sulfones; Treatment Outcome; Urea; Viral Load

2013
Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results.
    Antiviral therapy, 2013, Volume: 18, Issue:8

    Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load

2013
Effects of amino acids enriched tears substitutes on the cornea of patients with dysfunctional tear syndrome.
    Acta ophthalmologica, 2013, Volume: 91, Issue:6

    Topics: Aged; Amino Acids; Cornea; Double-Blind Method; Drug Therapy, Combination; Female; Fluorescein; Fluorescent Dyes; Fluorophotometry; Glycine; Humans; Hyaluronic Acid; Leucine; Lysine; Microscopy, Confocal; Middle Aged; Ophthalmic Nerve; Ophthalmic Solutions; Proline; Prospective Studies; Sjogren's Syndrome; Surveys and Questionnaires; Tears

2013
Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: safety, antiviral activity, resistance, and pharmacokinetics.
    Antiviral research, 2013, Volume: 99, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Carrier Proteins; Cyclopropanes; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Protease Inhibitors; Sulfonamides; Viral Nonstructural Proteins; Young Adult

2013
Emergence of resistance-associated variants after failed triple therapy with vaniprevir in treatment-experienced non-cirrhotic patients with hepatitis C-genotype 1 infection: a population and clonal analysis.
    Virology, 2013, Sep-01, Volume: 443, Issue:2

    Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Peptide Hydrolases; Polyethylene Glycols; Proline; Ribavirin; RNA, Viral; Sulfonamides; Treatment Failure; Treatment Outcome; Viremia; Young Adult

2013
Viral resistance in hepatitis C virus genotype 1-infected patients receiving the NS3 protease inhibitor Faldaprevir (BI 201335) in a phase 1b multiple-rising-dose study.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:10

    Topics: Aminoisobutyric Acids; Antiviral Agents; Cell Line; Genotype; Genotyping Techniques; Hepacivirus; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins

2013
Faldaprevir and deleobuvir for HCV genotype 1 infection.
    The New England journal of medicine, 2013, Aug-15, Volume: 369, Issue:7

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; DNA-Directed RNA Polymerases; Enzyme Inhibitors; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load

2013
Safety and efficacy of faldaprevir with pegylated interferon alfa-2a and ribavirin in Japanese patients with chronic genotype-1 hepatitis C infection.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34, Issue:1

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Asian People; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Time Factors; Treatment Outcome

2014
Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Placebos; Proline; Ribavirin; Sulfonamides; Treatment Outcome; Viral Load; Young Adult

2014
Evolutionary dynamics of hepatitis C virus NS3 protease domain during and following treatment with narlaprevir, a potent NS3 protease inhibitor.
    Journal of viral hepatitis, 2013, Volume: 20, Issue:11

    Topics: Adult; Antiviral Agents; Cyclopropanes; Dipeptides; Drug Therapy, Combination; Evolution, Molecular; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Leucine; Longitudinal Studies; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sequence Analysis, DNA; Sulfones; Urea; Viral Load; Viral Nonstructural Proteins

2013
Mass balance and metabolite profiling of steady-state faldaprevir, a hepatitis C virus NS3/4 protease inhibitor, in healthy male subjects.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:4

    Topics: Adolescent; Adult; Aminoisobutyric Acids; Hepacivirus; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Young Adult

2014
SILEN-C3, a phase 2 randomized trial with faldaprevir plus pegylated interferon α-2a and ribavirin in treatment-naive hepatitis C virus genotype 1-infected patients.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6

    Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles; Viral Nonstructural Proteins; Young Adult

2014
Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.
    Journal of hepatology, 2014, Volume: 61, Issue:3

    Topics: Acrylates; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Contraindications; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Virus Replication

2014
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Nov-15, Volume: 59, Issue:10

    Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult

2014
Vaniprevir plus peginterferon alfa-2a and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase II study.
    Journal of gastroenterology, 2015, Volume: 50, Issue:2

    Topics: Adult; Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Sulfonamides; Viral Load; Young Adult

2015
Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:2

    Topics: Aminoisobutyric Acids; Animals; Bilirubin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Hyperbilirubinemia; Leucine; Liver; Macaca mulatta; Multicenter Studies as Topic; Multidrug Resistance-Associated Protein 2; Oligopeptides; Proline; Quinolines; Randomized Controlled Trials as Topic; Rats; Thiazoles

2014
Interferon-free treatment of chronic hepatitis C with faldaprevir, deleobuvir and ribavirin: SOUND-C3, a Phase 2b study.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:2

    Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Treatment Outcome

2015
Pharmacokinetics, safety, and tolerability of faldaprevir in patients with renal impairment.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1

    Topics: Adult; Aged; Aminoisobutyric Acids; Biological Availability; Female; Half-Life; Hepatitis C; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Renal Insufficiency; Thiazoles

2015
Effect of faldaprevir on raltegravir pharmacokinetics in healthy volunteers.
    Journal of clinical pharmacology, 2015, Volume: 55, Issue:4

    Topics: Adult; Aminoisobutyric Acids; Drug Administration Schedule; Drug Interactions; Female; Genotype; Glucuronosyltransferase; Healthy Volunteers; HIV Integrase Inhibitors; Humans; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Raltegravir Potassium; Thiazoles; Young Adult

2015
Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1

    Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Interactions; Female; Humans; Leucine; Male; Methadone; Middle Aged; Oligopeptides; Proline; Quinolines; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles; Young Adult

2015
Effect of the hepatitis C virus protease inhibitor faldaprevir on the pharmacokinetics of an oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aminoisobutyric Acids; Area Under Curve; Bilirubin; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Leucine; Levonorgestrel; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins; Young Adult

2015
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation.
    Journal of clinical pharmacology, 2015, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Aminoisobutyric Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Hepatitis C; Humans; In Vitro Techniques; Isoenzymes; Leucine; Male; Microsomes, Liver; Midazolam; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Warfarin; Young Adult

2015
Efficacy and safety of faldaprevir, deleobuvir, and ribavirin in treatment-naive patients with chronic hepatitis C virus infection and advanced liver fibrosis or cirrhosis.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:2

    Topics: Acrylates; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Female; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Ribavirin; Thiazoles; Young Adult

2015
STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection.
    Journal of hepatology, 2015, Volume: 62, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles

2015
Faldaprevir and pegylated interferon α-2a/ribavirin in individuals co-infected with hepatitis C virus genotype-1 and HIV.
    AIDS (London, England), 2015, Mar-13, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Leucine; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load; Viremia; Young Adult

2015
Liver-to-plasma vaniprevir (MK-7009) concentration ratios in HCV-infected patients.
    Antiviral therapy, 2015, Volume: 20, Issue:8

    Topics: Administration, Oral; Adult; Aged; Antiviral Agents; Biopsy; Cyclopropanes; Drug Monitoring; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Liver Cirrhosis; Male; Middle Aged; Proline; Sulfonamides

2015
Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins

2015
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.
    Journal of gastroenterology, 2016, Volume: 51, Issue:4

    Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Sulfonamides; Treatment Outcome; Young Adult

2016
Open-label study of faldaprevir plus peginterferon and ribavirin in hepatitis C virus genotype 1-infected patients who failed placebo plus peginterferon and ribavirin.
    Journal of viral hepatitis, 2016, Volume: 23, Issue:3

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Placebos; Proline; Quinolines; Ribavirin; Salvage Therapy; Thiazoles; Treatment Outcome

2016
ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Acrylates; Aminoisobutyric Acids; Anemia; Antiviral Agents; Benzimidazoles; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Male; Middle Aged; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Pyrophosphatases; Quinolines; Real-Time Polymerase Chain Reaction; Ribavirin; Thiazoles

2015
Potent Antiviral Activities of the Direct-Acting Antivirals ABT-493 and ABT-530 with Three-Day Monotherapy for Hepatitis C Virus Genotype 1 Infection.
    Antimicrobial agents and chemotherapy, 2015, Dec-28, Volume: 60, Issue:3

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Microbial Sensitivity Tests; Middle Aged; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Young Adult

2015
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 (GT1b) infection: Phase 3 studies.
    Journal of gastroenterology and hepatology, 2016, Volume: 31, Issue:10

    Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; RNA, Viral; Sulfonamides; Viral Load; Young Adult

2016
HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials.
    Antiviral research, 2016, Volume: 130

    Topics: Amino Acid Substitution; Antiviral Agents; Codon; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Evolution, Molecular; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mutation; Phylogeny; Proline; Sequence Analysis, DNA; Sulfonamides; Treatment Failure; Treatment Outcome

2016
GS-9857 in patients with chronic hepatitis C virus genotype 1-4 infection: a randomized, double-blind, dose-ranging phase 1 study.
    Journal of viral hepatitis, 2016, Volume: 23, Issue:8

    Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Placebos; Proline; Quinoxalines; Sulfonamides; Treatment Outcome; Viral Load; Young Adult

2016
A Protease Inhibitor with Induction Therapy with Natural Interferon-β in Patients with HCV Genotype 1b Infection.
    International journal of molecular sciences, 2016, Mar-09, Volume: 17, Issue:3

    Topics: Aged; Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-beta; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Simeprevir; Sulfonamides

2016
Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants.
    The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:4

    Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Food-Drug Interactions; Healthy Volunteers; Hepacivirus; Humans; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Oligopeptides; Omeprazole; Proline; Protease Inhibitors; Proton Pump Inhibitors; Quinolines; Risk Factors; Thiazoles; Viral Nonstructural Proteins; Young Adult

2016
Short article: Faldaprevir, deleobuvir and ribavirin in IL28B non-CC patients with HCV genotype-1a infection included in the SOUND-C3 phase 2b study.
    European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:8

    Topics: Acrylates; Adult; Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Leucine; Male; Middle Aged; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA, Viral; Sustained Virologic Response; Thiazoles; Time Factors; Treatment Outcome; United States

2016
Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections.
    Gastroenterology, 2016, Volume: 151, Issue:3

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; New Zealand; Proline; Protease Inhibitors; Quinoxalines; Serine Proteases; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Viral Nonstructural Proteins; Young Adult

2016
High Efficacy of ABT-493 and ABT-530 Treatment in Patients With HCV Genotype 1 or 3 Infection and Compensated Cirrhosis.
    Gastroenterology, 2016, Volume: 151, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Fibrosis; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides; Sustained Virologic Response

2016
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial.
    Gastroenterology, 2016, Volume: 151, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Serine Proteases; Sofosbuvir; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins; Young Adult

2016
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Genotype 1 Hepatitis C Virus Infection in an Open-Label, Phase 2 Trial.
    Gastroenterology, 2016, Volume: 151, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Ribavirin; Serine Proteases; Sofosbuvir; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins; Young Adult

2016
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of ABT-493: A First-In-Human Study.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:2

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Administration Schedule; Female; Food-Drug Interactions; Hepatitis; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Placebo Effect; Proline; Quinoxalines; Sulfonamides

2017
HCVerso3: An Open-Label, Phase IIb Study of Faldaprevir and Deleobuvir with Ribavirin in Hepatitis C Virus Genotype-1b-Infected Patients with Cirrhosis and Moderate Hepatic Impairment.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Acrylates; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Prognosis; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Viral Load; Young Adult

2016
Glecaprevir and pibrentasvir for 12 weeks for hepatitis C virus genotype 1 infection and prior direct-acting antiviral treatment.
    Hepatology (Baltimore, Md.), 2017, Volume: 66, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Confidence Intervals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Lactams, Macrocyclic; Leucine; Liver Function Tests; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retreatment; Ribavirin; Sulfonamides; Time Factors; Treatment Outcome; United States; Viral Load; Young Adult

2017
Sofosbuvir-velpatasvir-voxilaprevir with or without ribavirin in direct-acting antiviral-experienced patients with genotype 1 hepatitis C virus.
    Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:6

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Confidence Intervals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Prospective Studies; Quinoxalines; Ribavirin; Severity of Illness Index; Sofosbuvir; Sulfonamides; Treatment Outcome; Young Adult

2017
Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.
    Gastroenterology, 2017, Volume: 153, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Young Adult

2017
Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis.
    Journal of hepatology, 2017, Volume: 67, Issue:2

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides; Sustained Virologic Response; Treatment Failure

2017
Effect of Steady-State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open-Label, Fixed-Sequence Crossover Study.
    Journal of clinical pharmacology, 2017, Volume: 57, Issue:10

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Atorvastatin; Cross-Over Studies; Drug Interactions; Female; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Male; Middle Aged; Oligopeptides; Proline; Pyrimidines; Quinolines; Rosuvastatin Calcium; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles

2017
Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.
    The New England journal of medicine, 2017, 06-01, Volume: 376, Issue:22

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Proline; Protease Inhibitors; Quinoxalines; Sofosbuvir; Sulfonamides; Viral Nonstructural Proteins

2017
Pharmacokinetic Interactions and Safety of Coadministration of Glecaprevir and Pibrentasvir in Healthy Volunteers.
    European journal of drug metabolism and pharmacokinetics, 2018, Volume: 43, Issue:1

    Topics: Adolescent; Adult; Alanine Transaminase; Aminoisobutyric Acids; Antiviral Agents; Aspartate Aminotransferases; Benzimidazoles; Bilirubin; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Female; Healthy Volunteers; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Young Adult

2018
No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:10

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cyclopropanes; Drug Interactions; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Methadone; Middle Aged; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Surveys and Questionnaires; Young Adult

2017
Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial.
    The Lancet. Infectious diseases, 2017, Volume: 17, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2017
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:2

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response

2018
Glecaprevir/pibrentasvir for hepatitis C virus genotype 3 patients with cirrhosis and/or prior treatment experience: A partially randomized phase 3 clinical trial.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response

2018
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis.
    Journal of gastroenterology, 2018, Volume: 53, Issue:4

    Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ritonavir; RNA, Viral; Sulfonamides; Sustained Virologic Response; Valine; Viral Nonstructural Proteins

2018
Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018, Volume: 16, Issue:3

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Placebos; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome

2018
Glecaprevir and Pibrentasvir in Patients with HCV and Severe Renal Impairment.
    The New England journal of medicine, 2017, 10-12, Volume: 377, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; RNA, Viral; Sulfonamides; Viral Load

2017
Characterization of HCV resistance from a 3-day monotherapy study of voxilaprevir, a novel pangenotypic NS3/4A protease inhibitor.
    Antiviral therapy, 2018, Volume: 23, Issue:4

    Topics: Aminoisobutyric Acids; Cell Line; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Protease Inhibitors; Quinoxalines; RNA, Viral; Sequence Analysis, RNA; Sulfonamides; Time Factors; Treatment Outcome; Viral Load; Virus Replication

2018
IFNL4 Genotype Is Associated With Virologic Relapse After 8-Week Treatment With Sofosbuvir, Velpatasvir, and Voxilaprevir.
    Gastroenterology, 2017, Volume: 153, Issue:6

    Topics: Aminoisobutyric Acids; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Interleukins; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Recurrence; Sofosbuvir; Sulfonamides; Sustained Virologic Response

2017
Glecaprevir/Pibrentasvir in patients with hepatitis C virus genotype 1 or 4 and past direct-acting antiviral treatment failure.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:4

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome; Young Adult

2018
Integrated Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in Japan.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoquinolines; Japan; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Viral Nonstructural Proteins

2018
Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:3

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Benzimidazoles; Cyclopropanes; Drug Administration Schedule; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepacivirus; Hepatitis C; Humans; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Renal Dialysis; Renal Insufficiency, Chronic; Sulfonamides

2018
Glecaprevir-Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection.
    The New England journal of medicine, 2018, 01-25, Volume: 378, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sofosbuvir; Sulfonamides; Valine; Viral Load

2018
Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:1

    Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Graft Rejection; Healthy Volunteers; Hepatitis C; Humans; Immunosuppressive Agents; Leucine; Liver Transplantation; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Quinolines; Secondary Prevention; Tacrolimus; Thiazoles; Young Adult

2018
A Phase 1 Study to Evaluate the Effect of Crushing, Cutting Into Half, or Grinding of Glecaprevir/Pibrentasvir Tablets on Exposures in Healthy Subjects.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Benzimidazoles; Biological Availability; Cross-Over Studies; Cyclopropanes; Female; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Particle Size; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Tablets

2018
High SVR12 with 8-week and 12-week glecaprevir/pibrentasvir therapy: An integrated analysis of HCV genotype 1-6 patients without cirrhosis.
    Journal of hepatology, 2018, Volume: 69, Issue:2

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Time Factors; Treatment Outcome

2018
Glecaprevir/Pibrentasvir Treatment in Liver or Kidney Transplant Patients With Hepatitis C Virus Infection.
    Hepatology (Baltimore, Md.), 2018, Volume: 68, Issue:4

    Topics: Adult; Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Graft Rejection; Graft Survival; Hepatitis C, Chronic; Humans; Internationality; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Liver Transplantation; Male; Middle Aged; Prognosis; Proline; Pyrrolidines; Quinoxalines; Risk Assessment; Sulfonamides; Transplant Recipients; Treatment Outcome

2018
Deferred treatment with sofosbuvir-velpatasvir-voxilaprevir for patients with chronic hepatitis C virus who were previously treated with an NS5A inhibitor: an open-label substudy of POLARIS-1.
    The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:8

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; RNA, Viral; Sofosbuvir; Sulfonamides; Treatment Failure; Viral Nonstructural Proteins

2018
Viral eradication is required for sustained improvement of patient-reported outcomes in patients with hepatitis C.
    Liver international : official journal of the International Association for the Study of the Liver, 2019, Volume: 39, Issue:1

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Linear Models; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Multivariate Analysis; Patient Reported Outcome Measures; Proline; Quality of Life; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response

2019
Pooled Resistance Analysis in Patients with Hepatitis C Virus Genotype 1 to 6 Infection Treated with Glecaprevir-Pibrentasvir in Phase 2 and 3 Clinical Trials.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:10

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response

2018
No impact of resistance-associated substitutions on the efficacy of sofosbuvir, velpatasvir, and voxilaprevir for 12 weeks in HCV DAA-experienced patients.
    Journal of hepatology, 2018, Volume: 69, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; High-Throughput Nucleotide Sequencing; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome; Viral Nonstructural Proteins

2018
Resistance Analysis of a 3-Day Monotherapy Study with Glecaprevir or Pibrentasvir in Patients with Chronic Hepatitis C Virus Genotype 1 Infection.
    Viruses, 2018, 08-28, Volume: 10, Issue:9

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Fibrosis; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Viral Load

2018
Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures.
    Journal of gastroenterology, 2019, Volume: 54, Issue:3

    Topics: Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Recurrence; Retreatment; Sulfonamides; Treatment Failure; Treatment Outcome

2019
Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial.
    The lancet. Gastroenterology & hepatology, 2019, Volume: 4, Issue:1

    Topics: Adult; Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Combinations; Fatigue; Female; Genotype; Headache; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult

2019
Glecaprevir/Pibrentasvir in patients with chronic HCV genotype 3 infection: An integrated phase 2/3 analysis.
    Journal of viral hepatitis, 2019, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult

2019
Glecaprevir/pibrentasvir in patients with chronic HCV and recent drug use: An integrated analysis of 7 phase III studies.
    Drug and alcohol dependence, 2019, 01-01, Volume: 194

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Drug Users; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult

2019
Safety and efficacy of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C in patients aged 65 years or older.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Kidney; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome

2019
Sofosbuvir/Velpatasvir/Voxilaprevir for patients with HCV who previously received a Sofosbuvir/Velpatasvir-containing regimen: Results from a retreatment study.
    Journal of viral hepatitis, 2019, Volume: 26, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Sustained Virologic Response

2019
A prospective study of daclatasvir and sofosbuvir in chronic HCV-infected kidney transplant recipients.
    BMC nephrology, 2019, 02-04, Volume: 20, Issue:1

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Biopsy, Needle; Calcineurin Inhibitors; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Glucose Intolerance; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Kidney Failure, Chronic; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Liver; Macrocyclic Compounds; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; RNA, Viral; Salvage Therapy; Sofosbuvir; Sulfonamides; Treatment Outcome; Valine; Viral Load; Viral Nonstructural Proteins; Viremia

2019
Retreatment of patients who failed glecaprevir/pibrentasvir treatment for hepatitis C virus infection.
    Journal of hepatology, 2019, Volume: 70, Issue:5

    Topics: Adult; Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure

2019
The efficacy and safety of glecaprevir plus pibrentasvir in 141 patients with severe renal impairment: a prospective, multicenter study.
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Renal Dialysis; Renal Insufficiency, Chronic; Severity of Illness Index; Sulfonamides; Sustained Virologic Response

2019
Safety and Pharmacokinetics of Glecaprevir/Pibrentasvir in Adults With Chronic Genotype 1-6 Hepatitis C Virus Infections and Compensated Liver Disease.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019, 10-30, Volume: 69, Issue:10

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Liver Diseases; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response

2019
A pilot study of safety and efficacy of HCV retreatment with sofosbuvir/velpatasvir/voxilaprevir in patients with or without HIV (RESOLVE STUDY).
    Journal of hepatology, 2019, Volume: 71, Issue:3

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; HIV Infections; HIV-1; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Pilot Projects; Proline; Quinoxalines; Recurrence; RNA, Viral; Sofosbuvir; Sulfonamides; Sustained Virologic Response

2019
Effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C previously treated with DAAs.
    Journal of hepatology, 2019, Volume: 71, Issue:4

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Monitoring; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Spain; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2019
Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:3

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Benzimidazoles; Biological Availability; Body Weight; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Female; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Models, Biological; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Young Adult

2020
Simplified monitoring for hepatitis C virus treatment with glecaprevir plus pibrentasvir, a randomised non-inferiority trial.
    Journal of hepatology, 2020, Volume: 72, Issue:3

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Drug Monitoring; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Young Adult

2020
Glecaprevir/pibrentasvir for 8 weeks in treatment-naïve patients with chronic HCV genotypes 1-6 and compensated cirrhosis: The EXPEDITION-8 trial.
    Journal of hepatology, 2020, Volume: 72, Issue:3

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Sustained Virologic Response; Viral Nonstructural Proteins

2020
Efficacy and safety of glecaprevir/pibrentasvir in renally impaired patients with chronic HCV infection.
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:5

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Fine-Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection.
    Clinical pharmacology and therapeutics, 2020, Volume: 107, Issue:6

    Topics: Adult; Antiviral Agents; Biopsy, Fine-Needle; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Male; Middle Aged; Proline; Sulfonamides; Tissue Distribution; Young Adult

2020
Efficacy and safety of glecaprevir/pibrentasvir in patients with HCV genotype 5/6: An integrated analysis of phase 2/3 studies.
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:10

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2020
[Efficacy and safety of narlaprevir/ritonavir and daclatasvir non interferon combination in population of Russian patients with chronic hepatitis C].
    Terapevticheskii arkhiv, 2019, Aug-15, Volume: 91, Issue:8

    Topics: Adult; Antiviral Agents; Carbamates; Cyclopropanes; Dipeptides; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Leucine; Middle Aged; Proline; Pyrrolidines; Ritonavir; Russia; Sulfones; Treatment Outcome; Urea; Valine

2019
A Thorough QT Study of the Combination Glecaprevir + Pibrentasvir on Cardiac Repolarization in Healthy Subjects.
    Clinical therapeutics, 2020, Volume: 42, Issue:7

    Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Combinations; Electrocardiography; Female; Healthy Volunteers; Heart; Heart Rate; Humans; Lactams, Macrocyclic; Leucine; Long QT Syndrome; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Single-Blind Method; Sulfonamides; Young Adult

2020
Glecaprevir-pibrentasvir to treat chronic hepatitis C virus infection in Asia: two multicentre, phase 3 studies- a randomised, double-blind study (VOYAGE-1) and an open-label, single-arm study (VOYAGE-2).
    The lancet. Gastroenterology & hepatology, 2020, Volume: 5, Issue:9

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Asia; Benzimidazoles; Case-Control Studies; Cyclopropanes; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Placebos; Prevalence; Proline; Pyrrolidines; Quinoxalines; Respiratory Tract Infections; Safety; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea

2022
Multicenter Study to Transplant Hepatitis C-Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection.
    Journal of the American Society of Nephrology : JASN, 2020, Volume: 31, Issue:11

    Topics: Adult; Allografts; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Glomerular Filtration Rate; Hepacivirus; Hepatitis C; Humans; Kidney; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Male; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Sustained Virologic Response

2020
Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Pilot Projects; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides; Sustained Virologic Response

2021
Positive predictive value of sustained virologic response 4 weeks posttreatment for achieving sustained virologic response 12 weeks posttreatment in patients receiving glecaprevir/pibrentasvir in Phase 2 and 3 clinical trials.
    Journal of viral hepatitis, 2021, Volume: 28, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Predictive Value of Tests; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2021
An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19.
    Diabetes & metabolic syndrome, 2022, Volume: 16, Issue:2

    Topics: Adenosine Monophosphate; Aged; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Double-Blind Method; Drug Approval; Drug Combinations; Female; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Male; Middle Aged; Nitriles; Proline; Ritonavir; SARS-CoV-2; Severity of Illness Index; Treatment Outcome

2022
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
    The New England journal of medicine, 2022, 04-14, Volume: 386, Issue:15

    Topics: Administration, Oral; Adult; Antiviral Agents; COVID-19 Drug Treatment; Disease Progression; Double-Blind Method; Hospitalization; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Treatment Outcome; Vaccination; Viral Load; Viral Protease Inhibitors

2022
Safety and efficacy of sofosbuvir-velpatasvir-voxilaprevir for re-treatment of chronic hepatitis C virus infection in patients with previous direct-acting antiviral treatment failure in Rwanda (SHARED-3): a single-arm trial.
    The lancet. Gastroenterology & hepatology, 2022, Volume: 7, Issue:6

    Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Death, Sudden; Female; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Quinoxalines; Rwanda; Sofosbuvir; Sulfonamides; Treatment Failure

2022
Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin-A Randomized Controlled Clinical Trial.
    Viruses, 2022, 03-16, Volume: 14, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; COVID-19; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Pandemics; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides

2022
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir.
    Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:1

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022

Other Studies

1481 other study(ies) available for proline and leucine

ArticleYear
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:10

    Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste

1987
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
    The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20

    Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis

2001
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
    Bioorganic & medicinal chemistry, 2011, Nov-01, Volume: 19, Issue:21

    Topics: Amino Acid Transport Systems; Caco-2 Cells; Endocytosis; Humans; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters

2011
Basic and neutral amino acid transport in Aspergillus nidulans.
    Journal of general microbiology, 1976, Volume: 92, Issue:1

    Topics: Amino Acids; Arginine; Aspergillus nidulans; Azides; Binding, Competitive; Biological Transport, Active; Cycloheximide; Fungal Proteins; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Membrane Transport Proteins; Methionine; Mutation; Ornithine; Phenylalanine; Proline; Serine

1976
Effects of Na+ depletion, theophylline and 2,4-dinitrophenol on neutral amino acid influx and cyclic adenosine 3':5'-monophosphate levels in chicken small intestine.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1976, Volume: 53, Issue:2

    Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Chickens; Cyclic AMP; Dinitrophenols; Glycine; Intestinal Mucosa; Intestine, Small; Kinetics; Leucine; Male; Proline; Sodium; Theophylline

1976
Chiroptical properties of fluorescamine condensation compounds with secondary amino acids in situ.
    Biochemical and biophysical research communications, 1976, Jul-26, Volume: 71, Issue:2

    Topics: Amino Acids; Binding Sites; Chemical Phenomena; Chemistry; Circular Dichroism; Fluorescamine; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Conformation; Proline; Spiro Compounds

1976
Adaptive enhancement of amino acid uptake and exodus by thymic lymphocytes: influence of pH.
    Journal of cellular physiology, 1976, Volume: 89, Issue:3

    Topics: Aminoisobutyric Acids; Animals; Biological Transport, Active; Culture Media; Cycloheximide; Dactinomycin; Hydrogen-Ion Concentration; Kinetics; Leucine; Proline; Rats; T-Lymphocytes; Time Factors

1976
Peptides related to melanostatin (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor.
    Acta pharmaceutica Suecica, 1976, Volume: 13, Issue:4

    Topics: Animals; Glycine; Leucine; Male; Mice; MSH Release-Inhibiting Hormone; Oxotremorine; Peptides; Proline; Tremor

1976
The fluorescence of fluorescamine-amino acids.
    Archives of biochemistry and biophysics, 1978, Volume: 189, Issue:2

    Topics: Alanine; Amino Acids; Chemical Phenomena; Chemistry, Physical; Fluorescamine; Hydrogen-Ion Concentration; Kinetics; Leucine; Proline; Spectrometry, Fluorescence; Spiro Compounds; Tryptophan

1978
Nuclear-magnetic-resonance study of aggregations and conformations of melanostatin and related peptides.
    European journal of biochemistry, 1978, Sep-01, Volume: 89, Issue:2

    Topics: Glycine; Leucine; Magnetic Resonance Spectroscopy; MSH Release-Inhibiting Hormone; Proline; Protein Binding; Protein Conformation; Structure-Activity Relationship

1978
Metabolic changes in Crithidia fasciculata accompanying physiological adaptation to growth in the presence of carbonyl cyanide m-chlorophenylhydrazone.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1979, Volume: 62, Issue:4

    Topics: Adaptation, Physiological; Adenine Nucleotides; Alanine; Animals; Biological Transport; Carbon Dioxide; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Crithidia; Energy Metabolism; Hydrogen-Ion Concentration; Leucine; Nitriles; Oxygen Consumption; Proline; Tyrosine

1979
Autoradiographic demonstration of afferent connections of the accessory olfactory bulb in the mouse.
    Brain research, 1975, Feb-28, Volume: 85, Issue:2

    Topics: Amygdala; Animals; Autoradiography; Axonal Transport; Brain Mapping; Female; Leucine; Male; Mice; Nasal Septum; Neural Pathways; Neurons, Afferent; Olfactory Bulb; Peripheral Nerves; Proline; Tritium

1975
Substrate specificity of the amino acyl adenylate activation sites of gramicidin S-synthetase (GSS).
    Acta microbiologica Academiae Scientiarum Hungaricae, 1975, Volume: 22, Issue:4

    Topics: Acetylation; Adenosine Monophosphate; Amino Acid Isomerases; Amino Acids; Bacillus; Binding Sites; Esters; Gramicidin; Leucine; Lysine; Multienzyme Complexes; Ornithine; Peptide Synthases; Phenylalanine; Proline; Stereoisomerism; Valine

1975
A light microscopic, autoradiographic study of axoplasmic transport in the normal rhesus optic nerve head.
    American journal of ophthalmology, 1976, Volume: 82, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Axons; Haplorhini; Leucine; Macaca mulatta; Optic Nerve; Proline; Retina; Tritium

1976
Uptake of L-proline by Histoplasma capsulatum.
    Canadian journal of microbiology, 1976, Volume: 22, Issue:8

    Topics: Amino Acids; Azetidinecarboxylic Acid; Biological Transport, Active; Carboxylic Acids; Diffusion; Histoplasma; Leucine; Proline; Sarcosine; Stereoisomerism

1976
Efferents from medial basal forebrain and hypothalamus in the rat. I. An autoradiographic study of the medial preoptic area.
    The Journal of comparative neurology, 1976, Sep-15, Volume: 169, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Efferent Pathways; Female; Hypothalamus; Leucine; Male; Preoptic Area; Proline; Rats

1976
Efferents from medial basal forebrain and hypothalamus in the rat. II. An autoradiographic study of the anterior hypothalamus.
    The Journal of comparative neurology, 1976, Sep-15, Volume: 169, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Efferent Pathways; Female; Hypothalamus; Hypothalamus, Anterior; Leucine; Male; Proline; Rats

1976
The topographical organization of the olivo-dentate and dentato-olivary pathways in the cat.
    Brain research, 1976, Oct-15, Volume: 115, Issue:2

    Topics: Animals; Axonal Transport; Cats; Cerebellar Nuclei; Horseradish Peroxidase; Leucine; Neural Pathways; Olivary Nucleus; Proline

1976
The efferent connections of the ventromedial nucleus of the hypothalamus of the rat.
    The Journal of comparative neurology, 1976, Oct-15, Volume: 169, Issue:4

    Topics: Animals; Axonal Transport; Brain; Efferent Pathways; Hypothalamus; Hypothalamus, Middle; Leucine; Lysine; Proline; Rats

1976
Direct hypothalamo-autonomic connections.
    Brain research, 1976, Nov-26, Volume: 117, Issue:2

    Topics: Animals; Axonal Transport; Brain Stem; Cats; Haplorhini; Horseradish Peroxidase; Hypothalamus; Leucine; Lysine; Macaca fascicularis; Neural Pathways; Proline; Rats; Spinal Cord; Sympathetic Nervous System; Vagus Nerve

1976
A light microscopic, autoradiographic study of axoplasmic transport in the optic nerve head during ocular hypotony, increased intraocular pressure, and papilledema.
    American journal of ophthalmology, 1976, Volume: 82, Issue:5

    Topics: Animals; Anterior Chamber; Autoradiography; Axonal Transport; Cryosurgery; Glaucoma; Haplorhini; Intraocular Pressure; Leucine; Macaca mulatta; Optic Disk; Optic Nerve; Papilledema; Proline; Sclera; Tritium

1976
Reutilization of precursor following axonal transport of [3H]proline-labeled protein.
    Brain research, 1977, Feb-18, Volume: 122, Issue:2

    Topics: Acetohexamide; Animals; Asparagine; Axonal Transport; Axons; Cycloheximide; Goldfish; Hydroxyproline; Leucine; Nerve Tissue Proteins; Optic Nerve; Proline; Superior Colliculi

1977
Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis).
    The Journal of comparative neurology, 1977, Mar-01, Volume: 172, Issue:1

    Topics: Amygdala; Animals; Axonal Transport; Cerebral Cortex; Efferent Pathways; Leucine; Nerve Degeneration; Olfactory Bulb; Olfactory Pathways; Proline; Shrews

1977
An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat.
    The Journal of comparative neurology, 1977, Mar-01, Volume: 172, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Cerebral Cortex; Efferent Pathways; Hippocampus; Leucine; Lysine; Proline; Rats

1977
Differential distribution of corticospinal projections from individual cytoarchitectonic fields in the monkey.
    Brain research, 1977, Jul-01, Volume: 129, Issue:2

    Topics: Animals; Axonal Transport; Cerebral Cortex; Haplorhini; Leucine; Macaca fascicularis; Neural Pathways; Proline; Spinal Cord

1977
Evidence for selective axon-terminal uptake and retrograde transport of label in cortico- and rubrospinal systems after injection of 3H-proline.
    Experimental brain research, 1977, May-23, Volume: 28, Issue:1-2

    Topics: Afferent Pathways; Animals; Axonal Transport; Geniculate Bodies; Haplorhini; Leucine; Macaca mulatta; Motor Cortex; Olivary Nucleus; Proline; Red Nucleus; Reticular Formation; Spinal Cord; Synapses

1977
Rapid axoplasmic transport in the olfactory nerve of the pike: I. Basic transport parameters for proteins and amino acids.
    Brain research, 1978, Jan-06, Volume: 139, Issue:1

    Topics: Amino Acids; Animals; Axonal Transport; Female; Fishes; Leucine; Male; Nerve Tissue Proteins; Olfactory Bulb; Olfactory Mucosa; Olfactory Nerve; Proline; Temperature; Tritium

1978
Rapid axoplasmic transport in the olfactory nerve of the pike: II. Analysis of transported proteins by SDS gel electrophoresis.
    Brain research, 1978, Jan-06, Volume: 139, Issue:1

    Topics: Animals; Axonal Transport; Electrophoresis, Polyacrylamide Gel; Fishes; Leucine; Molecular Weight; Nerve Tissue Proteins; Olfactory Bulb; Olfactory Mucosa; Olfactory Nerve; Proline; Receptors, Neurotransmitter; Sodium Dodecyl Sulfate; Tritium

1978
Projections of auditory nerve in the cat as seen by anterograde transport methods.
    Neuroscience, 1979, Volume: 4, Issue:9

    Topics: Animals; Axonal Transport; Cats; Cochlear Nerve; Fucose; Leucine; Medulla Oblongata; Proline; Vestibulocochlear Nerve

1979
Connectivity of the auditory forebrain nuclei in the guinea fowl (Numida meleagris).
    Cell and tissue research, 1979, Aug-03, Volume: 200, Issue:1

    Topics: Animals; Auditory Cortex; Autoradiography; Birds; Brain Mapping; Female; Leucine; Male; Neural Pathways; Proline; Silver; Staining and Labeling; Tritium

1979
Olivocerebellar projections in the cat studied by means of anterograde axonal transport of labelled amino acids as tracers.
    Neuroscience, 1979, Volume: 4, Issue:11

    Topics: Afferent Pathways; Amino Acids; Animals; Autoradiography; Axonal Transport; Cats; Cerebellum; Cerebral Cortex; Efferent Pathways; Leucine; Olivary Nucleus; Proline; Tritium

1979
Superior colliculus efferents to the hypothalamus.
    Neuroscience letters, 1979, Volume: 14, Issue:2-3

    Topics: Adenosine; Animals; Autoradiography; Axonal Transport; Efferent Pathways; Female; Hypothalamus; Hypothalamus, Anterior; Leucine; Male; Microscopy, Electron; Proline; Rabbits; Rats; Superior Colliculi; Supraoptic Nucleus

1979
Odontoblast metabolism in rats deficient in vitamin D and calcium. III. Protein synthesis in vitro.
    Journal of oral pathology, 1978, Volume: 7, Issue:4

    Topics: Animals; Body Weight; Calcium; Cells, Cultured; Fucose; Leucine; Male; Odontoblasts; Phosphates; Proline; Protein Biosynthesis; Rats; Vitamin D Deficiency

1978
The unstable Hb Genova (beta 28Leu replaced by Pro) in an East African Family. Family study and the effect of splenectomy.
    Acta haematologica, 1979, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Kenya; Leucine; Male; Middle Aged; Pedigree; Pregnancy; Proline; Splenectomy

1979
Rabbit cranial sutures in vitro: a new experimental model for studying the response of fibrous joints to mechanical stress.
    Calcified tissue international, 1979, Oct-31, Volume: 28, Issue:2

    Topics: Animals; Collagen; Hydroxyproline; Leucine; Models, Biological; Organ Culture Techniques; Proline; Proteins; Rabbits; Skull; Stress, Mechanical; Tensile Strength; Tritium

1979
The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats.
    Chemico-biological interactions, 1979, Volume: 28, Issue:2-3

    Topics: Amino Acids; Aminobutyrates; Animals; Arsenates; Arsenic; Aspartic Acid; Betaine; Circadian Rhythm; Erythrocytes; Female; Glutamine; Glycine; Hydroxyproline; Isoleucine; Leucine; Male; Ornithine; Proline; Rats; Serine; Sex Factors; Starvation; Taurine; Valine

1979
Stimulation of growth and mucopolysaccharide synthesis by insulin treatment of chick embryo chondrocytes in cell culture.
    General and comparative endocrinology, 1975, Volume: 25, Issue:4

    Topics: Acetates; Amino Acids; Animals; Ascorbic Acid; Blood; Cartilage; Cattle; Cells, Cultured; Chick Embryo; Collagen; Glycosaminoglycans; Insulin; Leucine; Proline; Sulfur Radioisotopes; Sulfuric Acids; Tritium

1975
Transport of sugars and amino acids in bacteria. XIV. Preferential inhibition of oxidase activities and active transport reactions for amino acids by azidebenzenes.
    Journal of biochemistry, 1975, Volume: 78, Issue:1

    Topics: Adenosine Triphosphatases; Amino Acids; Azides; Biological Transport, Active; Escherichia coli; Glycerol; Isoleucine; Leucine; Oxidation-Reduction; Oxygen Consumption; Proline; Succinate Dehydrogenase; Succinates

1975
Energy coupling in the active transport of amino acids by bacteriohodopsin-containing cells of Halobacterium holobium.
    Journal of bacteriology, 1976, Volume: 125, Issue:1

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acids; Bacteriorhodopsins; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dicyclohexylcarbodiimide; Glycerol; Halobacterium; Histidine; Leucine; Light; Photophosphorylation; Proline

1976
Effects of estrogen to alter amino acid transport in R3230AC mammary carcinomas and its relationship to insulin action.
    Cancer research, 1979, Volume: 39, Issue:9

    Topics: Adenocarcinoma; Amino Acids; Animals; Biological Transport; Castration; Cell Line; Diabetes Mellitus, Experimental; Estradiol; Estrogens; Female; In Vitro Techniques; Insulin; Insulin Antagonists; Leucine; Mammary Neoplasms, Experimental; Proline; Rats; RNA, Neoplasm; Streptozocin; Substrate Specificity; Time Factors

1979
Tyrocidine synthetase system.
    Methods in enzymology, 1975, Volume: 43

    Topics: Aminoacylation; Asparagine; Bacillus; Cell Division; Chromatography, DEAE-Cellulose; Glutamine; Leucine; Ligases; Methods; Molecular Weight; Multienzyme Complexes; Ornithine; Phenylalanine; Proline; Time Factors; Tyrocidine; Tyrosine; Tyrothricin; Valine

1975
Programmed synthesis of collagen during postembryonic development of the nematode Panagrellus silusiae.
    Developmental biology, 1975, Volume: 47, Issue:1

    Topics: Animals; Collagen; Hydroxyproline; Leucine; Nematoda; Procollagen-Proline Dioxygenase; Proline; Time Factors; Tryptophan

1975
Collagen biosynthesis by cultured Chinese hamster lung cells. Cell-free synthesis of procollagen alpha chains.
    Biochemistry, 1978, Mar-07, Volume: 17, Issue:5

    Topics: Cell Line; Cell-Free System; Leucine; Macromolecular Substances; Microbial Collagenase; Molecular Weight; Procollagen; Proline

1978
Protein synthesis of the peritoneal membrane and intra-abdominal adhaesions in silica-induced peritonitis.
    Acta chirurgica Scandinavica, 1977, Volume: 143, Issue:7-8

    Topics: Animals; Collagen; Injections, Intraperitoneal; Leucine; Male; Mucous Membrane; Peritoneum; Peritonitis; Proline; Protein Biosynthesis; Rats; Silicon Dioxide; Tissue Adhesions

1977
Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study.
    Virchows Archiv. B, Cell pathology, 1975, Volume: 17, Issue:3

    Topics: Amino Acids; Animals; Autoradiography; D-Amino-Acid Oxidase; Injections, Intraperitoneal; Kidney Tubules; Kidney Tubules, Proximal; Leucine; Liver; Male; Proline; Rats; Time Factors; Tritium

1975
Formation and excretion of pyrrole-2-carboxylic acid. Whole animal and enzyme studies in the rat.
    The Journal of biological chemistry, 1975, Apr-10, Volume: 250, Issue:7

    Topics: Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Amino Acids; Animals; Carboxylic Acids; Catalase; Cattle; Chromatography, Ion Exchange; D-Amino-Acid Oxidase; Guinea Pigs; Humans; Hydroxyproline; Kidney; Kinetics; Leucine; Liver; Proline; Pyrroles; Rats; Swine

1975
Haemoglobin Saki alpha 2 beta 2 14 Leu-Pro(a11) structure and function.
    Biochimica et biophysica acta, 1975, May-30, Volume: 393, Issue:1

    Topics: Adult; Amino Acid Sequence; Amino Acids; Diphosphoglyceric Acids; Drug Stability; Female; France; Hemoglobins, Abnormal; Hot Temperature; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Japan; Kinetics; Leucine; Oxygen; Peptide Fragments; Proline; Protein Binding; Time Factors; Trypsin

1975
Isolation and functional characterization of hemoglobin Casper: beta106(G8) Leu replaced by Pro.
    Biochemistry, 1975, Nov-04, Volume: 14, Issue:22

    Topics: Diphosphoglyceric Acids; England; Erythrocytes; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Leucine; Oxygen; Proline

1975
A comparison of collagen and non-collagenous protein metabolism in rat molar and incisor periodontal ligaments.
    Archives of oral biology, 1978, Volume: 23, Issue:11

    Topics: Amino Acids; Animals; Collagen; Incisor; Leucine; Male; Molar; Periodontal Ligament; Proline; Proteins; Rats; Time Factors

1978
Alteration of free serum amino acids in voles infected with Trypanosoma brucei gambiense.
    The Journal of parasitology, 1977, Volume: 63, Issue:1

    Topics: Alanine; Amino Acids; Animals; Arvicolinae; Circadian Rhythm; Glutamates; Glycine; Isoleucine; Leucine; Male; Proline; Serine; Threonine; Trypanosomiasis, African; Tryptophan; Tyrosine; Valine

1977
Incorporation of 14C-amino acids into rat hypothalamus in vitro.
    Endocrinologia experimentalis, 1977, Volume: 11, Issue:1

    Topics: Amino Acids; Animals; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Leucine; Male; Oxytocin; Proline; Protein Biosynthesis; Rats

1977
Study of the transfer RNAs coded by T2, T4, and T6 bacteriophages.
    The Journal of biological chemistry, 1977, Jul-25, Volume: 252, Issue:14

    Topics: Arginine; Base Sequence; Chromatography; Coliphages; DNA, Viral; Escherichia coli; Glycine; Isoleucine; Leucine; Nucleic Acid Hybridization; Proline; RNA, Transfer; RNA, Viral

1977
Relationship between messenger ribonucleic acid and enzyme levels specified by the leucine operon of Escherichia coli K-12.
    Journal of bacteriology, 1977, Volume: 131, Issue:3

    Topics: 2-Isopropylmalate Synthase; Culture Media; Escherichia coli; Leucine; Operon; Oxidoreductases; Oxo-Acid-Lyases; Plasmids; Proline; RNA, Bacterial; RNA, Messenger

1977
Branched-chain amino acid transport regulation in mutants blocked in tRNA maturation and transcriptional termination.
    Journal of bacteriology, 1978, Volume: 134, Issue:2

    Topics: Amino Acids; Biological Transport, Active; Escherichia coli; Genes; Isoleucine; Leucine; Proline; Rho Factor; RNA, Bacterial; RNA, Transfer; Transcription Factors; Valine

1978
A single mutation affects L-serine deaminase, L-leucyl-, L-phenylalanyl-tRNA protein transferase, and proline oxidase activity in Escherichia coli K-12.
    Journal of bacteriology, 1978, Volume: 135, Issue:3

    Topics: Acyltransferases; Enzyme Induction; Escherichia coli; Genes; L-Serine Dehydratase; Leucine; Maltose; Mutation; Oxygenases; Proline; RNA, Transfer

1978
Regulation of cell size in the yeast Saccharomyces cerevisiae.
    Journal of bacteriology, 1979, Volume: 137, Issue:1

    Topics: Ammonium Sulfate; Cell Cycle; Culture Media; Leucine; Proline; Saccharomyces cerevisiae

1979
Regulation of proline dehydrogenase activity in Escherichia coli by leucyl-, phenylalanyl-tRNA:protein transferase.
    The Journal of biological chemistry, 1979, Mar-10, Volume: 254, Issue:5

    Topics: Acyltransferases; Escherichia coli; Leucine; Molecular Weight; Oxygenases; Phenylalanine; Proline; RNA, Transfer, Amino Acyl; Species Specificity

1979
Pools and protein synthesis in mammalian cells.
    The Biochemical journal, 1979, Mar-15, Volume: 178, Issue:3

    Topics: Amino Acids; Animals; Cell Line; Cricetinae; Glycine; HeLa Cells; Kinetics; Leucine; p-Fluorophenylalanine; Phenylalanine; Proline; Protein Biosynthesis

1979
Proline oxidase in cultured mammalian cells.
    Journal of cellular physiology, 1977, Volume: 91, Issue:3

    Topics: Animals; Carbon Dioxide; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Fibroblasts; Humans; Hydroxyproline; Kidney; Leucine; Leukocytes; Mice; Mitochondria; Mitochondria, Liver; Oxidoreductases Acting on CH-NH Group Donors; Proline; Rabbits; Rats; Stereoisomerism

1977
Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for the analysis of peptide hormone interactions with bovine neurophysin I using 13C nuclear magnetic resonance spectroscopy.
    Biochemistry, 1977, Nov-15, Volume: 16, Issue:23

    Topics: Animals; Binding Sites; Carbon Isotopes; Cattle; Leucine; Magnetic Resonance Spectroscopy; Neurophysins; Oxytocin; Proline; Protein Binding; Protein Conformation

1977
Inhibitory effects of tunicamycin on procollagen biosynthesis and secretion.
    Biochimica et biophysica acta, 1977, Nov-07, Volume: 500, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Chick Embryo; Glucosamine; Glycine; Guanosine Diphosphate Mannose; Leucine; Mannose; Procollagen; Proline; Proteins; Uridine Diphosphate N-Acetylglucosamine

1977
Factors affecting plasma amino acid concentrations in control subjects.
    Metabolism: clinical and experimental, 1979, Volume: 28, Issue:4

    Topics: Adolescent; Adult; Aged; Amino Acids; Circadian Rhythm; Cystine; Dietary Proteins; Eating; Fasting; Female; Humans; Isoleucine; Leucine; Male; Methionine; Middle Aged; Proline; Sex Factors; Valine

1979
Diurnal variations in plasma concentrations of tryptophan, tryosine, and other neutral amino acids: effect of dietary protein intake.
    The American journal of clinical nutrition, 1979, Volume: 32, Issue:9

    Topics: Adult; Alanine; Amino Acids; Circadian Rhythm; Dietary Proteins; Glycine; Humans; Isoleucine; Leucine; Male; Middle Aged; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1979
Diurnal variations in plasma neutral amino acid concentrations among patients with cirrhosis: effect of dietary protein.
    The American journal of clinical nutrition, 1979, Volume: 32, Issue:9

    Topics: Adult; Aged; Amino Acids; Circadian Rhythm; Dietary Proteins; Hepatic Encephalopathy; Humans; Isoleucine; Leucine; Liver Cirrhosis, Alcoholic; Male; Methionine; Middle Aged; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1979
Thin layer chromatographic analyses of amino acids in Echinostoma revolutum (Trematoda) adults.
    International journal for parasitology, 1977, Volume: 7, Issue:6

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Chromatography, Thin Layer; Echinostoma; Isoleucine; Leucine; Methionine; Proline; Serine; Tyrosine; Valine

1977
Adaptive regulation of amino acid transport in cultured avian fibroblasts. Influence of the amino acid composition of the culture media.
    Biochimica et biophysica acta, 1978, Feb-02, Volume: 507, Issue:1

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Cells, Cultured; Culture Media; Cycloheximide; Leucine; Lysine; Proline

1978
Effects of insulin in vivo and in vitro on amino acid transport into cells from the R3230AC mammary adenocarcinoma and their relationship to tumor growth.
    Cancer research, 1978, Volume: 38, Issue:11 Pt 1

    Topics: Adenocarcinoma; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Insulin; Kinetics; Leucine; Mammary Neoplasms, Experimental; Proline; Rats; Sodium

1978
Effects of calcitonin on epidermal regeneration and collagen synthesis in rabbits with experimental wounds.
    Experimentelle Pathologie, 1978, Volume: 16, Issue:1-6

    Topics: Animals; Calcitonin; Collagen; Epidermis; Keratins; Leucine; Male; Proline; Rabbits; Regeneration; Thymidine; Uridine; Wound Healing

1978
[Comparative studies of recombinant selection and linkage determinations with culture media prepared from anchovy].
    Mikrobiyoloji bulteni, 1975, Volume: 9, Issue:2

    Topics: Arabinose; Arginine; Chromosome Mapping; Culture Media; Escherichia coli; Fish Products; Genes; Genetic Linkage; Leucine; Mutation; Proline; Recombination, Genetic; Threonine

1975
Amino acid starvation in Escherichia coli K-12: characteristics of the translation process.
    Journal of bacteriology, 1976, Volume: 126, Issue:3

    Topics: Amino Acids; Bacterial Proteins; Coliphages; Escherichia coli; Histidine; Leucine; Peptide Biosynthesis; Peptide Chain Elongation, Translational; Proline; Protein Biosynthesis; Ribosomes; Viral Proteins

1976
Mutagenesis in the strains E. coli K-12 with different ability to genetic recombination.
    Journal of hygiene, epidemiology, microbiology, and immunology, 1976, Volume: 20, Issue:4

    Topics: Alleles; Amino Acids; Arginine; Escherichia coli; Ethyl Methanesulfonate; Genes; Histidine; Leucine; Methylnitronitrosoguanidine; Mitomycins; Mutagens; Mutation; Proline; Recombination, Genetic; Threonine

1976
An autoradiographic study of the projections of the mammillothalamic tract in the rat.
    Brain research, 1975, Feb-28, Volume: 85, Issue:2

    Topics: Animals; Autoradiography; Brain Mapping; Female; Leucine; Male; Mammillary Bodies; Neural Pathways; Proline; Rats; Thalamus

1975
Notes on the application of radioactive amino acids for the tracing of neuronal connections.
    Brain research, 1975, Feb-28, Volume: 85, Issue:2

    Topics: Animals; Autoradiography; Basal Ganglia; Brain Mapping; Cats; Caudate Nucleus; Cerebellum; Cerebral Cortex; Haplorhini; Leucine; Neural Pathways; Proline; Putamen; Reticular Formation; Tegmentum Mesencephali; Tritium

1975
Properties of Bacillus megaterium temperature-sensitive germination mutants.
    Journal of bacteriology, 1975, Volume: 121, Issue:1

    Topics: Bacillus megaterium; Bromides; Drug Resistance, Microbial; Glucose; Leucine; Mutation; Picolinic Acids; Proline; Spores, Bacterial; Stereoisomerism; Streptomycin; Temperature; Tryptophan

1975
Incomplete tricarboxylic acid cycle in a type I methylotroph, Methylococcus capsulatus.
    Journal of bacteriology, 1975, Volume: 123, Issue:1

    Topics: Acetates; Arginine; Cell-Free System; Citric Acid Cycle; Glutamates; Ketoglutarate Dehydrogenase Complex; Leucine; Lipids; Methylococcaceae; Proline

1975
Assimilation of citric acid and adipic acid by the blue-green alga Anabaena variabilis.
    Canadian journal of microbiology, 1975, Volume: 21, Issue:9

    Topics: Adipates; Aspartic Acid; Chlorophyll; Citrates; Cyanobacteria; Darkness; Glutamates; Leucine; Light; Proline; Threonine

1975
[Amino acid pattern in endemic (Balkan-)nephropathy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1976, Jan-30, Volume: 118, Issue:5

    Topics: Adolescent; Adult; Alanine; Amino Acids; Bulgaria; Child; Citrulline; Cystine; Disease Reservoirs; Female; Glycine; Humans; Isoleucine; Leucine; Male; Methionine; Nephritis, Interstitial; Ornithine; Phenylalanine; Proline; Romania; Serine; Yugoslavia

1976
Synthesis of the glomerular basement membrane in the rat kidney. Autoradiographic studies with the light and electron microscope.
    Virchows Archiv. B, Cell pathology, 1976, Mar-09, Volume: 20, Issue:2

    Topics: Animals; Autoradiography; Basement Membrane; Epithelial Cells; Kidney; Kidney Glomerulus; Leucine; Male; Microscopy, Electron; Proline; Rats; Tritium

1976
The variability of human lambda-chain constant regions and some relationships to V-regions sequences.
    Immunochemistry, 1976, Volume: 13, Issue:2

    Topics: Alanine; Amino Acid Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cystine; Electrophoresis, Paper; Glutamates; Glycine; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Isoleucine; Leucine; Peptides; Proline; Serine; Thiazoles; Threonine; Valine

1976
Autoradiographic demonstration of a projection from prefrontal association cortex to the superior colliculus in the rhesus monkey.
    Brain research, 1976, Oct-29, Volume: 116, Issue:1

    Topics: Animals; Autoradiography; Cerebral Cortex; Haplorhini; Leucine; Macaca mulatta; Neural Pathways; Proline; Superior Colliculi

1976
Variations in the concentrations of blood plasma free amino acids in suckled and fasted neonatal pigs.
    Journal of animal science, 1977, Volume: 44, Issue:2

    Topics: Amino Acids; Animals; Animals, Newborn; Arginine; Cystine; Fasting; Glycine; Leucine; Lysine; Proline; Serine; Swine; Threonine; Tyrosine

1977
Glomerular protein synthesis in proteinuric rats.
    The Journal of laboratory and clinical medicine, 1977, Volume: 89, Issue:2

    Topics: Amino Acids; Animals; Basement Membrane; Hydroxylation; Hydroxyproline; In Vitro Techniques; Kidney Glomerulus; Leucine; Male; Proline; Proteins; Proteinuria; Rats; Tyrosine

1977
Cytologic and metabolic effects of prostaglandins on rat skin.
    The Journal of investigative dermatology, 1977, Volume: 68, Issue:3

    Topics: Animals; Autoradiography; Cell Nucleolus; Cell Nucleus; Collagen; Cytoplasm; Endoplasmic Reticulum; Fibroblasts; Injections, Intradermal; Injections, Intramuscular; Leucine; Male; Mitochondria; Proline; Prostaglandins E; Prostaglandins F; Rats; Skin; Thymidine; Uridine

1977
Regulation of Protein Synthesis in Hen's oviducts. I. Removal of extracellular and intracellular proteins and their effects on protein synthesis.
    Journal of biochemistry, 1977, Volume: 81, Issue:1

    Topics: Animals; Asparagine; Body Fluids; Chickens; Deoxycholic Acid; Egg Proteins; Extracellular Space; Female; Glycine; Intracellular Fluid; Leucine; Muramidase; Ovalbumin; Oviducts; Oviposition; Proline; Time Factors

1977
On the derivatives for the ultramicrodetermination of amino acids by mass fragmentography.
    Analytical biochemistry, 1977, Volume: 78, Issue:2

    Topics: Alanine; Amino Acids; Gas Chromatography-Mass Spectrometry; Glutamates; Indicators and Reagents; Leucine; Microchemistry; Proline; Valine

1977
The nature of the amino acid pool used for protein synthesis in cultured, androgen-responsive tumour cells.
    Experimental cell research, 1977, Volume: 106, Issue:1

    Topics: Amino Acids; Animals; Cell Line; Glycine; Intracellular Fluid; Kinetics; Leucine; Mammary Neoplasms, Experimental; Methionine; Mice; Proline; Protein Biosynthesis

1977
Hemoglobin Mizuho or beta 68 (E 12) leucine leads to proline, a new unstable variant associated with severe hemolytic anemia.
    Hemoglobin, 1977, Volume: 1, Issue:5

    Topics: Amino Acid Sequence; Anemia, Hemolytic; Child, Preschool; Female; Genetic Variation; Hemoglobins, Abnormal; Humans; Japan; Leucine; Peptides; Proline; Splenectomy

1977
Muscle amino acid arylpeptidases and their serum changes with exercise.
    European journal of applied physiology and occupational physiology, 1977, May-10, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Alanine; Aminopeptidases; Glycine; Humans; Leucine; Male; Muscles; Phenylalanine; Physical Exertion; Proline; Running; Skiing; Tyrosine

1977
beta-structures of alternating polypeptides and their possible role in chemical evolution.
    Bio Systems, 1977, Volume: 9, Issue:2-3

    Topics: Circular Dichroism; Glycine; Leucine; Lysine; Peptides; Proline; Protein Conformation; Solubility; Stereoisomerism; Structure-Activity Relationship

1977
Differential incorporation of tritiated proline and leucine by neurons of the dorsal column nuclei in the cat.
    Brain research, 1977, Sep-02, Volume: 132, Issue:3

    Topics: Animals; Axons; Cats; Female; Inferior Colliculi; Leucine; Male; Neurons; Olivary Nucleus; Proline; Spinal Cord

1977
Ovalbumin synthesis in a homologous cell-free system prepared from hen's oviduct.
    Journal of biochemistry, 1976, Volume: 79, Issue:5

    Topics: Adenosine Triphosphate; Animals; Cell-Free System; Chickens; Chromatography, Affinity; Dithiothreitol; Female; Kinetics; Leucine; Ovalbumin; Oviducts; Polyribosomes; Proline; Protein Biosynthesis

1976
The X-Pro peptide bond as an nmr probe for conformational studies of flexible linear peptides.
    Biopolymers, 1976, Volume: 15, Issue:10

    Topics: Alanine; Binding Sites; Glycine; Leucine; Magnetic Resonance Spectroscopy; Molecular Conformation; Peptides; Phenylalanine; Proline; Stereoisomerism

1976
Influence of D and L amino-acid residues on the conformation of peptides in solution: A carbon-13 nuclear magnetic resonance study of cyclo(prolyl-leucyl).
    Biopolymers, 1976, Volume: 15, Issue:9

    Topics: Amino Acid Sequence; Isomerism; Leucine; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Proline; Protein Conformation; Solutions; Stereoisomerism

1976
Alterations in proline metabolic enzymes with mammalian development.
    Metabolism: clinical and experimental, 1976, Volume: 25, Issue:10

    Topics: Aging; Animals; Carboxylic Acids; Female; Kidney; Kinetics; Leucine; Liver; Mitochondria, Liver; Organ Specificity; Oxidoreductases; Oxygenases; Pregnancy; Proline; Pyrroles; Rats; Stereoisomerism; Valine

1976
Thalassemia intermedia caused by heterozygosity for both beta-thalassemia and hemoglobin Saki [beta 14 (A11) Leu replaced by Pro].
    American journal of hematology, 1976, Volume: 1, Issue:3

    Topics: Adolescent; Hemoglobins; Heterozygote; Humans; Leucine; Male; Peptides; Proline; Thalassemia

1976
Plasma amino acids in children and adolescents on hemodialysis.
    Kidney international, 1976, Volume: 10, Issue:6

    Topics: Adolescent; Amino Acids; Child; Child Nutritional Physiological Phenomena; Citrulline; Diet; Female; Glycine; Growth; Histidine; Humans; Isoleucine; Leucine; Lysine; Male; Methylhistidines; Nutritional Physiological Phenomena; Proline; Renal Dialysis; Serine; Tyrosine; Valine

1976
The metabolic effects of glucagon infusion in normoglycaemic and hypoglycaemic small-for-gestational-age infants. II. Changes in plasma amino acids.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1976, Volume: 17, Issue:3

    Topics: Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Citrulline; Glucagon; Gluconeogenesis; Glycine; Humans; Hypoglycemia; Infant, Low Birth Weight; Infant, Newborn; Infant, Small for Gestational Age; Infusions, Parenteral; Isoleucine; Leucine; Liver; Proline; Valine

1976
The accessory fibers of the sperm tail. High-sulfur and low-sulfur components in mammals and cephalopods.
    Journal of ultrastructure research, 1976, Volume: 57, Issue:3

    Topics: Amino Acids; Animals; Aspartic Acid; Carbocysteine; Cattle; Electrophoresis, Polyacrylamide Gel; Glutamates; Humans; Leucine; Male; Molecular Weight; Mollusca; Octopodiformes; Proline; Proteins; Rats; Spectrophotometry, Infrared; Sperm Tail; Spermatozoa

1976
Amino acid composition, distribution and origin of "tuft" protein in human and bovine dental enamel.
    Archives of oral biology, 1975, Volume: 20, Issue:1

    Topics: Alanine; Amelogenesis; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Dental Enamel; Dental Enamel Proteins; Glutamates; Glycine; Histidine; Humans; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1975
Transport properties of merodiploids covering the dagA locus in Escherichia coli K-12.
    Journal of bacteriology, 1975, Volume: 122, Issue:3

    Topics: Alanine; Biological Transport, Active; Cell Membrane; Diploidy; Escherichia coli; Genes; Glycerol; Glycine; Kinetics; Leucine; Mutation; Proline; Serine; Stereoisomerism

1975
Specialized peptide transport system in Escherichia coli.
    Journal of bacteriology, 1975, Volume: 122, Issue:3

    Topics: Biological Transport, Active; Electrophoresis, Paper; Escherichia coli; Leucine; Lysine; Methionine; Mutation; Oligopeptides; Ornithine; Proline; Threonine; Valine

1975
Transport of sugars and amino acids in bacteria. XIII. Mechanism of selective inhibition of the active transport reactions for proline, leucine, and succinate by zinc ions.
    Journal of biochemistry, 1975, Volume: 78, Issue:1

    Topics: Biological Transport, Active; Chloromercuribenzoates; Escherichia coli; Fumarates; Glycerol; Lactates; Leucine; Magnesium; Oxygen Consumption; Proline; Succinate Dehydrogenase; Succinates; Zinc

1975
Non-parallel transport of membrane proteins and content proteins during assembly of the secretory granule in rat parotid gland.
    Biochimica et biophysica acta, 1975, Jan-14, Volume: 375, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Cytoplasmic Granules; Leucine; Male; Membranes; Parotid Gland; Proline; Proteins; Rats

1975
Projections from the retina to the lateral geniculate nucleus and mesencephalic tectum in a reptile (Tupinambis nigropunctatus): a comparison of anterograde transport and anterograde degeneration.
    Brain research, 1975, Feb-28, Volume: 85, Issue:2

    Topics: Animals; Autoradiography; Brain Mapping; Geniculate Bodies; Leucine; Lizards; Neural Pathways; Proline; Retina; Tectum Mesencephali; Tritium; Visual Pathways

1975
A single-chain triple helical structure in synthetic polypeptides.
    Experientia, 1975, Jan-15, Volume: 31, Issue:1

    Topics: Amino Acid Sequence; Collagen; Glycine; Leucine; Peptides; Proline; Protein Conformation; X-Ray Diffraction

1975
Incorporation of L-azetidine-2-carboxylic acid into hemoglobin in rabbit reticulocytes in vitro.
    The Journal of biological chemistry, 1975, Feb-25, Volume: 250, Issue:4

    Topics: Amino Acids; Animals; Azetidines; Azetines; Carboxylic Acids; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Globins; Hemoglobins; Kinetics; Leucine; Lysine; Peptide Fragments; Proline; Rabbits; Reticulocytes; Time Factors; Trypsin

1975
Distribution of radioactivity in the organs of the rat and mouse after injection of L-(3H)prolyl-L-leucyl-glycinamide.
    The Journal of endocrinology, 1975, Volume: 64, Issue:2

    Topics: Adipose Tissue; Adipose Tissue, Brown; Adrenal Glands; Animals; Cerebral Cortex; Epididymis; Glycine; Hippocampus; Hypothalamus; Injections, Intravenous; Intestinal Mucosa; Kidney; Leucine; Liver; Male; Oligopeptides; Pineal Gland; Pituitary Gland; Proline; Rats; Skin; Submandibular Gland; Testis; Tritium

1975
Hemoglobin Atlanta or alpha 2 beta 2 75 Leu-Pro (E19): an unstable variant found in several members of a Caucasian family.
    Biochimica et biophysica acta, 1975, Apr-29, Volume: 386, Issue:2

    Topics: Alanine; Amino Acids; Female; Georgia; Heinz Bodies; Hemoglobins, Abnormal; Humans; Leucine; Peptide Fragments; Proline; Protein Conformation; White People

1975
Sythesis of polypeptide models of collagen.
    International journal of peptide and protein research, 1975, Volume: 7, Issue:2

    Topics: Chemical Fractionation; Collagen; Glycine; Leucine; Molecular Weight; Peptides; Phenylalanine; Proline; Sarcosine; Valine

1975
Oxytocin analogs with substitutions in postions 3 and 4.
    International journal of peptide and protein research, 1975, Volume: 7, Issue:2

    Topics: Alanine; Animals; Chickens; Leucine; Oxytocin; Proline; Rats

1975
Some aspects of the organization of the thalamic reticular complex.
    The Journal of comparative neurology, 1975, Aug-01, Volume: 162, Issue:3

    Topics: Animals; Autoradiography; Cats; Cerebral Cortex; Leucine; Macaca; Macaca mulatta; Peroxidases; Proline; Rats; Reticular Formation; Saimiri; Thalamus; Tritium

1975
Observations on the lateral olfactory tract of the rat.
    The Journal of comparative neurology, 1975, Aug-01, Volume: 162, Issue:3

    Topics: Animals; Autoradiography; Axons; Central Nervous System; Leucine; Male; Myelin Sheath; Nerve Fibers, Myelinated; Olfactory Bulb; Olfactory Pathways; Proline; Rats; Tritium

1975
Conformational studies on sequential polypeptides. Part V. Synthesis and characterization of (Pro-Leu-Gly)10, (Pro-LeuqGly)n and (Leu-Pro-Gly)n.
    International journal of peptide and protein research, 1975, Volume: 7, Issue:3

    Topics: Amino Acid Sequence; Collagen; Glycine; Leucine; Molecular Weight; Peptides; Proline; Protein Conformation

1975
Significant differences in the degradation of pro-leu-gly-nH2 by human serum and that of other species (38484).
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 148, Issue:1

    Topics: Aminopeptidases; Animals; Brain; Carps; Chickens; Female; Glycine; Humans; Hydrolysis; Leucine; Male; Oligopeptides; Oxytocin; Peptide Fragments; Peptide Hydrolases; Pregnancy; Proline; Rats

1975
Amino acid reabsorption in the rat nephron. Free flow micropuncture study.
    Pflugers Archiv : European journal of physiology, 1975, Volume: 357, Issue:1-2

    Topics: Absorption; Alanine; Amino Acids; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Glutamates; Glycine; Isoleucine; Kidney; Kidney Tubules, Proximal; Leucine; Lysine; Male; Nephrons; Phenylalanine; Proline; Rats; Taurine; Tyrosine

1975
The uptake of endogenous proteins by oocyte nuclei.
    Experimental cell research, 1975, Volume: 93, Issue:2

    Topics: Animals; Cell Nucleus; Cytoplasm; Female; Glucosamine; Glycoproteins; Kinetics; Leucine; Microinjections; Molecular Weight; Oocytes; Ovum; Peptides; Proline; Puromycin; Xenopus

1975
Different targets of different neurons in nucleus gracilis of the cat.
    The Journal of comparative neurology, 1975, Oct-01, Volume: 163, Issue:3

    Topics: Animals; Brain Mapping; Cats; Horseradish Peroxidase; Leucine; Medulla Oblongata; Neural Pathways; Olivary Nucleus; Proline; Thalamic Nuclei; Tritium

1975
[Dipeptidase activity in the small intestine of patients with chronic nonspecific enteritis].
    Vutreshni bolesti, 1975, Volume: 14, Issue:1

    Topics: Adult; Alanine; Chronic Disease; Dipeptidases; Dipeptides; Enteritis; Female; Glutamates; Glycine; Humans; Intestine, Small; Isoleucine; Leucine; Male; Middle Aged; Proline; Valine

1975
Effect of prostaglandins on protein, RNA, DNA and collagen synthesis in experimental wounds.
    Prostaglandins, 1975, Volume: 10, Issue:4

    Topics: Animals; Collagen; DNA; Leucine; Male; Proline; Prostaglandins E; Prostaglandins F; Protein Biosynthesis; Rats; RNA; Stimulation, Chemical; Thymidine; Time Factors; Uridine; Wound Healing; Wounds and Injuries

1975
Conformational studies on sequential polypeptides Part VI. Structural investigations on (Pro-Leu-Gly)10, (Pro-Leu-Gly)n and (Leu-Pro-Gly)n.
    International journal of peptide and protein research, 1975, Volume: 7, Issue:6

    Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Circular Dichroism; Collagen; Glycine; Leucine; Peptides; Proline; Protein Conformation; Rats; X-Ray Diffraction

1975
Compartmentalization of amino acids in surfactant aggregates. Partitioning between water and aqueous micellar sodium deodecanoate and between hexane and dodecylammonium propionate trapped water in hexane.
    Journal of molecular evolution, 1975, Nov-04, Volume: 6, Issue:3

    Topics: Alanine; Alkanes; Amino Acids; Arginine; Aspartic Acid; Colloids; Glutamates; Glycine; Isoleucine; Laurates; Leucine; Lysine; Micelles; Phenylalanine; Proline; Serine; Solubility; Threonine; Valine

1975
Quantitative determinations by ion pair extraction. Part 12. Extraction of amino acids with quaternary ammonium ions.
    Acta pharmaceutica Suecica, 1975, Volume: 12, Issue:5-6

    Topics: Amino Acids; Chemical Phenomena; Chemistry; Hydroxyproline; Ion Exchange; Leucine; Methionine; Phenylalanine; Proline; Quaternary Ammonium Compounds; Solutions; Tryptophan

1975
[Free amino acids in the amniotic fluid and in maternal blood in advanced pregnancy].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1975, Volume: 4, Issue:7

    Topics: Alanine; Amino Acids; Amniotic Fluid; Cysteine; Female; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Pregnancy Trimester, Third; Proline; Serine; Threonine; Tyrosine; Valine

1975
A novel beta-globin structural mutant, Hb Brescia (beta 114 Leu-Pro), causing a severe beta-thalassemia intermedia phenotype.
    Human mutation, 1992, Volume: 1, Issue:2

    Topics: Adolescent; Base Sequence; beta-Thalassemia; Erythrocytes; Female; Globins; Hemoglobins, Abnormal; Humans; Italy; Leucine; Macromolecular Substances; Male; Molecular Sequence Data; Proline

1992
Mismatch PCR: a rapid method to screen for the Pro207-->Leu mutation in the lipoprotein lipase (LPL) gene.
    Human molecular genetics, 1992, Volume: 1, Issue:7

    Topics: Base Sequence; DNA, Single-Stranded; Genetic Testing; Humans; Leucine; Lipoprotein Lipase; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Proline

1992
Functional consequences of alterations to Pro328 and Leu332 located in the 4th transmembrane segment of the alpha-subunit of the rat kidney Na+,K(+)-ATPase.
    FEBS letters, 1992, Dec-21, Volume: 314, Issue:3

    Topics: Animals; Base Sequence; Cell Line; Cell Membrane; Cloning, Molecular; DNA; Female; Kidney; Leucine; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; Ouabain; Proline; Protein Conformation; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase

1992
Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0 (L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0.
    The Journal of antibiotics, 1992, Volume: 45, Issue:12

    Topics: Anti-Bacterial Agents; Antifungal Agents; Carbon Isotopes; Echinocandins; Glutamates; Glutamic Acid; Hydroxyproline; Leucine; Magnetic Resonance Spectroscopy; Mitosporic Fungi; Nitrogen Isotopes; Peptides; Peptides, Cyclic; Proline

1992
A new PKU mutation associated with haplotype 12.
    Human molecular genetics, 1992, Volume: 1, Issue:9

    Topics: Amino Acid Sequence; Base Sequence; Chromosomes, Human, Pair 12; Exons; Female; Haplotypes; Humans; Leucine; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenylalanine Hydroxylase; Phenylketonurias; Point Mutation; Polymorphism, Restriction Fragment Length; Proline

1992
An autoradiographic study of cortical projections from motor thalamic nuclei in the macaque monkey.
    Neuroscience research, 1992, Volume: 13, Issue:2

    Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Cerebellum; Cerebral Cortex; Globus Pallidus; Leucine; Macaca; Proline; Stereotaxic Techniques; Thalamic Nuclei; Tritium

1992
A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, May-15, Volume: 89, Issue:10

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; DNA; DNA Probes; Heterozygote; Leucine; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Molecular Sequence Data; Molecular Weight; Mutation; Myelin Proteins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proline; Protein Conformation; Restriction Mapping; RNA

1992
A leucine----proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis.
    Cell, 1992, Sep-04, Volume: 70, Issue:5

    Topics: Amino Acid Sequence; Base Sequence; Humans; Ichthyosiform Erythroderma, Congenital; Intermediate Filaments; Keratins; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline

1992
Pelizaeus-Merzbacher disease: detection of mutations Thr181----Pro and Leu223----Pro in the proteolipid protein gene, and prenatal diagnosis.
    American journal of human genetics, 1992, Volume: 51, Issue:4

    Topics: Amino Acid Sequence; Base Sequence; Chorionic Villi Sampling; Diffuse Cerebral Sclerosis of Schilder; DNA; Exons; Female; Genetic Counseling; Humans; Infant, Newborn; Leucine; Male; Molecular Sequence Data; Myelin Proteins; Myelin Proteolipid Protein; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Prenatal Diagnosis; Proline; Restriction Mapping; Threonine; X Chromosome

1992
Identification and expression of a common missense mutation (L302P) in the acid sphingomyelinase gene of Ashkenazi Jewish type A Niemann-Pick disease patients.
    Blood, 1992, Oct-15, Volume: 80, Issue:8

    Topics: Base Sequence; Cell Line; Codon; DNA; Gene Expression; Humans; Jews; Leucine; Molecular Sequence Data; Mutation; Niemann-Pick Diseases; Nucleic Acid Hybridization; Pedigree; Polymerase Chain Reaction; Proline; Sphingomyelin Phosphodiesterase; Transfection

1992
Intestinal amino acid and monosaccharide transport in suckling pigs fed milk replacers with different sources of carbohydrate.
    The Journal of nutrition, 1992, Volume: 122, Issue:12

    Topics: Aging; Amino Acids; Animals; Animals, Suckling; Biological Transport; Dietary Carbohydrates; Female; Food, Formulated; Fructose; Galactose; Glucose; Intestinal Absorption; Intestinal Mucosa; Lactose; Leucine; Male; Milk; Monosaccharides; Polysaccharides; Proline; Sucrose; Swine; Weight Gain

1992
Structure and activity studies of pardaxin and analogues using model membranes of phosphatidylcholine.
    Biochimica et biophysica acta, 1992, Dec-09, Volume: 1112, Issue:2

    Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Fish Venoms; Isoleucine; Leucine; Lipid Bilayers; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphatidylcholines; Proline; Protein Structure, Secondary; Solutions; Structure-Activity Relationship

1992
An mRNA that specifically accumulates in maize roots delineates a novel subset of developing cortical cells.
    Plant molecular biology, 1992, Volume: 20, Issue:5

    Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Gene Library; Genes; In Situ Hybridization; Leucine; Light-Harvesting Protein Complexes; Molecular Sequence Data; Photosynthetic Reaction Center Complex Proteins; Plant Proteins; Proline; Protein Conformation; RNA, Messenger; Zea mays

1992
Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PIA1) and HPA-1b (Zwb/PIA2).
    Human immunology, 1992, Volume: 34, Issue:4

    Topics: Antigens, Human Platelet; Blood Platelets; Histocompatibility Testing; HLA-DR Antigens; HLA-DR Serological Subtypes; Humans; Integrin beta3; Isoantibodies; Leucine; Membrane Glycoproteins; Phenotype; Proline

1992
Diffuse loss of rod function in autosomal dominant retinitis pigmentosa with pro-347-leu mutation of rhodopsin.
    German journal of ophthalmology, 1992, Volume: 1, Issue:5

    Topics: Adult; Aged; Dark Adaptation; DNA Mutational Analysis; Electroretinography; Female; Fundus Oculi; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Photoreceptor Cells; Proline; Retinal Diseases; Retinitis Pigmentosa; Rhodopsin; Visual Fields

1992
A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level.
    British journal of haematology, 1992, Volume: 81, Issue:1

    Topics: Anemia, Hemolytic; Base Sequence; Blotting, Southern; Chromosome Deletion; Codon; DNA; Female; Globins; Hemoglobins, Abnormal; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Proline; RNA, Messenger

1992
Antithrombin III Budapest: a single amino acid substitution (429Pro to Leu) in a region highly conserved in the serpin family.
    Blood, 1992, Mar-01, Volume: 79, Issue:5

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antithrombin III; Base Sequence; DNA; Heparin; Homozygote; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Proline; Thrombin; Thromboembolism

1992
Rhodamine B inhibits collagen synthesis by human lip fibroblasts in culture.
    Toxicology letters, 1992, Volume: 61, Issue:1

    Topics: Cell Count; Cells, Cultured; Collagen; Cosmetics; DNA; Dose-Response Relationship, Drug; Extracellular Matrix; Humans; L-Lactate Dehydrogenase; Leucine; Lip; Proline; Rhodamines; Thymidine

1992
Differential helix propensity of small apolar side chains studied by molecular dynamics simulations.
    Biochemistry, 1992, Jun-23, Volume: 31, Issue:24

    Topics: Alanine; Amino Acids; Aminobutyrates; Glycine; Hydrogen Bonding; Leucine; Peptides; Proline; Protein Conformation; Structure-Activity Relationship; Thermodynamics; Valine

1992
Amino acid incorporation in cell cultures from eyes with pseudo-exfoliation material.
    Acta ophthalmologica, 1992, Volume: 70, Issue:3

    Topics: Anterior Eye Segment; Cells, Cultured; Conjunctival Diseases; Extracellular Matrix; Eye Diseases; Humans; Leucine; Proline

1992
Spontaneous neurodegeneration in transgenic mice with prion protein codon 101 proline----leucine substitution.
    Annals of the New York Academy of Sciences, 1991, Volume: 640

    Topics: Amino Acid Sequence; Animals; Brain; Codon; Gene Expression; Gerstmann-Straussler-Scheinker Disease; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Prions; Proline; PrPSc Proteins

1991
A simple ordering of neocortical areas established by the compartmental organization of their striatal projections.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:16

    Topics: Animals; Autoradiography; Axonal Transport; Cats; Cerebral Cortex; Corpus Striatum; Leucine; Methionine; Proline; Tritium

1990
Visual corticopontine and tectopontine projections in the macaque.
    Archives italiennes de biologie, 1990, Volume: 128, Issue:2-4

    Topics: Animals; Autoradiography; Evoked Potentials; Histocytochemistry; Horseradish Peroxidase; Leucine; Macaca fascicularis; Occipital Lobe; Pons; Proline; Staining and Labeling; Superior Colliculi; Visual Cortex; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins

1990
A 13-mer peptide straddling the leucine33/proline33 polymorphism in glycoprotein IIIa does not define the PLA1 epitope.
    Blood, 1991, May-01, Volume: 77, Issue:9

    Topics: Amino Acid Sequence; Antigens, Human Platelet; Deoxyribonucleases, Type II Site-Specific; DNA; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoblotting; Integrin beta3; Isoantigens; Leucine; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Proline; Protein Conformation; Subtilisins

1991
[Molecular genetic analysis of neurologic diseases].
    Human cell, 1990, Volume: 3, Issue:4

    Topics: Amino Acid Sequence; Base Sequence; Epilepsies, Myoclonic; Gaucher Disease; Glucosylceramidase; Homozygote; Humans; Leucine; Molecular Sequence Data; Mutation; Proline; RNA; RNA, Mitochondrial; RNA, Transfer, Lys

1990
Compartmental organization of the thalamostriatal connection in the cat.
    The Journal of comparative neurology, 1991, Sep-01, Volume: 311, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Cats; Caudate Nucleus; Corpus Striatum; Leucine; Nerve Fibers; Proline; Putamen; Thalamus; Tritium

1991
Connectional studies of the primate lateral geniculate nucleus: distribution of axons arising from the thalamic reticular nucleus of Galago crassicaudatus.
    The Journal of comparative neurology, 1991, Aug-15, Volume: 310, Issue:3

    Topics: Animals; Autoradiography; Axonal Transport; Axons; Dendrites; Galago; Geniculate Bodies; Leucine; Microscopy, Electron; Proline; Thalamic Nuclei; Tritium

1991
Proline metabolism in adult male burned patients and healthy control subjects.
    The American journal of clinical nutrition, 1991, Volume: 54, Issue:2

    Topics: Adult; Burns; Carbon Isotopes; Deuterium; Humans; Kinetics; Leucine; Male; Oxidation-Reduction; Proline

1991
Identification of the 664 proline to leucine mutation in the low density lipoprotein receptor in four unrelated patients with familial hypercholesterolaemia in the UK.
    Clinical genetics, 1991, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Base Sequence; Codon; Female; Genetic Carrier Screening; Haplotypes; Humans; Hyperlipoproteinemia Type II; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Receptors, LDL; United Kingdom

1991
Molecular and endocrine characterization of a mutation involving a recombination between the steroid 21-hydroxylase functional gene and pseudogene.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 38, Issue:6

    Topics: Adrenal Hyperplasia, Congenital; Amino Acid Sequence; Base Sequence; DNA; Female; Genes, MHC Class II; HLA-B Antigens; HLA-B44 Antigen; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Polymerase Chain Reaction; Proline; Pseudogenes; Recombination, Genetic; Steroid 21-Hydroxylase

1991
Gaucher disease: heterologous expression of two alleles associated with neuronopathic phenotypes.
    American journal of human genetics, 1991, Volume: 49, Issue:3

    Topics: Acute Disease; Alleles; Animals; Arginine; Baculoviridae; beta-Glucosidase; Cell Line; Cells, Cultured; Gaucher Disease; Gene Expression; Humans; Immunoblotting; Insecta; Leucine; Lysosomes; Mutagenesis, Site-Directed; Phenotype; Proline

1991
Analysis of neutral amino acid transport systems in the small intestine: a study of brush border membrane vesicles.
    Gastroenterologia Japonica, 1991, Volume: 26, Issue:3

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Culture Media; Cysteine; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Microvilli; Proline; Serine

1991
Secondary structure and side-chain 1H and 13C resonance assignments of calmodulin in solution by heteronuclear multidimensional NMR spectroscopy.
    Biochemistry, 1991, Sep-24, Volume: 30, Issue:38

    Topics: Alanine; Amino Acid Sequence; Amino Acids, Branched-Chain; Amino Acids, Diamino; Amino Acids, Dicarboxylic; Animals; Asparagine; Binding Sites; Calcium; Calmodulin; Drosophila melanogaster; Glutamine; Glycine; Hydrogen Bonding; Leucine; Magnetic Resonance Spectroscopy; Methionine; Molecular Sequence Data; Molecular Structure; Proline; Recombinant Proteins; Serine; Solutions; Threonine

1991
Dual mode of corticothalamic synaptic termination in the mediodorsal nucleus of the rhesus monkey.
    The Journal of comparative neurology, 1991, Jul-15, Volume: 309, Issue:3

    Topics: Animals; Autoradiography; Axons; Cerebral Cortex; Dendrites; Leucine; Macaca mulatta; Microscopy, Electron; Proline; Synapses; Thalamus; Tritium

1991
A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface.
    Biochemistry, 1991, Nov-05, Volume: 30, Issue:44

    Topics: Animals; Biological Transport; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Gene Expression; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Kinetics; Leucine; Mutation; Phosphorylation; Proline; Protein Precursors; Receptor, Insulin; Transfection

1991
Fibrinogen Kanazawa: a congenital dysfibrinogenaemia with delayed polymerization having a replacement of proline-18 by leucine in the A alpha-chain.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1991, Volume: 2, Issue:3

    Topics: Adult; Amino Acid Sequence; Blood Coagulation Disorders; Blood Coagulation Tests; Female; Fibrinogens, Abnormal; Fibrinopeptide A; Fibrinopeptide B; Humans; Leucine; Molecular Sequence Data; Polymers; Proline

1991
Non-existence of a tight association between a 444leucine to proline mutation and phenotypes of Gaucher disease: high frequency of a NciI polymorphism in the non-neuronopathic form.
    Human genetics, 1990, Volume: 84, Issue:2

    Topics: Deoxyribonucleases, Type II Site-Specific; Female; Gaucher Disease; Humans; Leucine; Male; Mutation; Pedigree; Phenotype; Polymorphism, Restriction Fragment Length; Proline

1990
Molecular sizes of amino acid transporters in the luminal membrane from the kidney cortex, estimated by the radiation-inactivation method.
    The Biochemical journal, 1990, May-15, Volume: 268, Issue:1

    Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Animals; Benzoates; Benzoic Acid; Biological Transport; Carrier Proteins; Cell Membrane Permeability; Dose-Response Relationship, Radiation; Free Radicals; Gamma Rays; Glutamates; Glutamic Acid; Kidney Cortex; Kinetics; Leucine; Microvilli; Proline; Rats; Sodium

1990
Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Jan-15, Volume: 88, Issue:2

    Topics: Amino Acid Sequence; Aminoglutethimide; Androstenedione; Animals; Arginine; Aromatase; Base Sequence; Cell Line; Humans; Kinetics; Leucine; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phenylalanine; Proline; Substrate Specificity; Testosterone; Transfection; Tyrosine

1991
Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3.
    Blood, 1991, Mar-15, Volume: 77, Issue:6

    Topics: Adenine; Anemia, Hemolytic; Base Sequence; Cytosine; DNA; Exons; Female; Guanine; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Phosphoglycerate Kinase; Proline; Thymine

1991
Ocular findings in patients with autosomal dominant retinitis pigmentosa and rhodopsin, proline-347-leucine.
    American journal of ophthalmology, 1991, May-15, Volume: 111, Issue:5

    Topics: Adolescent; Adult; Amino Acid Sequence; Chromosome Aberrations; Chromosome Disorders; Dark Adaptation; Electroretinography; Female; Fundus Oculi; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Night Blindness; Pedigree; Proline; Retinitis Pigmentosa; Rhodopsin; Visual Fields

1991
Influence of high glucose concentrations on glycosaminoglycan and collagen synthesis in cultured human gingival fibroblasts.
    Journal of clinical periodontology, 1991, Volume: 18, Issue:3

    Topics: Adult; Cell Count; Cells, Cultured; Collagen; Connective Tissue; Connective Tissue Cells; Fibroblasts; Gingiva; Glucosamine; Glucose; Glycopeptides; Glycosaminoglycans; Humans; Hyaluronic Acid; Leucine; Proline; Tritium

1991
Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.
    Blood, 1991, Jul-01, Volume: 78, Issue:1

    Topics: Adult; Amino Acid Sequence; Chromatography, High Pressure Liquid; Congenital Abnormalities; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogens, Abnormal; Genetic Variation; Humans; Leucine; Molecular Sequence Data; Proline

1991
A mutation (Pro-30 to Leu) in CYP21 represents a potential nonclassic steroid 21-hydroxylase deficiency allele.
    Molecular endocrinology (Baltimore, Md.), 1991, Volume: 5, Issue:5

    Topics: Adrenal Hyperplasia, Congenital; Alleles; Animals; Base Sequence; Female; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Pedigree; Proline; Rabbits; Recombinant Proteins; Steroid 21-Hydroxylase; Vaccinia virus

1991
Chloride-dependence of amino acid transport in rabbit ileum.
    Biochimica et biophysica acta, 1990, Aug-10, Volume: 1027, Issue:1

    Topics: Amino Acids; Animals; beta-Alanine; Chlorides; Female; Glucose; Ileum; Jejunum; Leucine; Proline; Rabbits; Sodium

1990
Amino acid substitutions Phe66----Leu and Ser126----Pro abolish cortisol and aldosterone synthesis by bovine cytochrome P450(11)beta.
    The Journal of biological chemistry, 1990, Nov-25, Volume: 265, Issue:33

    Topics: Adrenal Cortex; Aldosterone; Animals; Base Sequence; Cattle; Cell Line; Cloning, Molecular; Codon; Desoxycorticosterone; DNA; Hydrocortisone; Leucine; Mitochondria; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phenylalanine; Plasmids; Polymerase Chain Reaction; Proline; RNA, Messenger; Serine; Steroid 11-beta-Hydroxylase; Transfection

1990
Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:3

    Topics: Adult; Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Codon; DNA; DNA Restriction Enzymes; Exons; Family; Gene Amplification; Genes; Humans; Hypoproteinemia; Leucine; Male; Molecular Sequence Data; Proline; Promoter Regions, Genetic; Racial Groups; Thyronines; Thyroxine-Binding Proteins

1990
Cloning of genes required for amino acid biosynthesis from Leptospira interrogans serovar icterohaemorrhagiae.
    Journal of general microbiology, 1990, Volume: 136, Issue:4

    Topics: Amino Acids; Bacterial Typing Techniques; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genetic Complementation Test; Leptospira interrogans; Leucine; Mutation; Nucleic Acid Hybridization; Proline; Restriction Mapping

1990
Analysis of lens protein synthesis in a cataractous mutant mouse: the Cat Fraser.
    Experimental eye research, 1990, Volume: 51, Issue:5

    Topics: Animals; Cataract; Collagen; Crystallins; Epithelium; Hydroxyproline; Lens Capsule, Crystalline; Lens, Crystalline; Leucine; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Proline

1990
Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica.
    Connective tissue research, 1990, Volume: 24, Issue:2

    Topics: Cell Count; Cell Survival; Cells, Cultured; Collagen; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Hydroxyproline; Leucine; Male; Pentacyclic Triterpenes; Procollagen; Proline; RNA, Transfer, Pro; Terpenes; Triterpenes

1990
Plasma proline kinetics and concentrations in young men in response to dietary proline deprivation.
    The American journal of clinical nutrition, 1990, Volume: 52, Issue:2

    Topics: Adult; Amino Acids; Analysis of Variance; Dietary Proteins; Humans; Kinetics; Leucine; Male; Oxidation-Reduction; Proline

1990
A double-isotope procedure for examining protein microheterogeneity: multiple forms of fast-transported glycoproteins and sulfoproteins possess a common polypeptide chain.
    Journal of neurochemistry, 1986, Volume: 46, Issue:2

    Topics: Animals; Axonal Transport; Biological Transport, Active; Electrophoresis, Polyacrylamide Gel; Ganglia, Spinal; Glycoproteins; Isoelectric Focusing; Leucine; Methionine; Methods; Proline; Proteins; Rana catesbeiana; Sulfuric Acids

1986
Telencephalic projections from midbrain and isthmal cell groups in the pigeon. I. Locus coeruleus and subcoeruleus.
    The Journal of comparative neurology, 1986, May-01, Volume: 247, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Brain Mapping; Brain Stem; Cerebellum; Columbidae; Efferent Pathways; Female; Horseradish Peroxidase; Leucine; Limbic System; Locus Coeruleus; Male; Nucleus Accumbens; Proline; Species Specificity; Spinal Cord; Telencephalon

1986
A glial-neuronal-glial communication system in the mammalian central nervous system.
    Brain research, 1987, Jun-23, Volume: 414, Issue:1

    Topics: Animals; Arcuate Nucleus of Hypothalamus; Autoradiography; Axonal Transport; Axons; Brain; Cats; Cell Communication; Female; Leucine; Male; Medulla Oblongata; Microscopy, Electron; Neuroglia; Neurons; Proline; Spinal Cord

1987
The disturbance of the fast axonal transport of protein by passive stretching of an axon in Aplysia.
    The Journal of physiology, 1987, Volume: 390

    Topics: Animals; Aplysia; Axonal Transport; Axons; Cells, Cultured; Leucine; Proline; Proteins; Stress, Mechanical

1987
Vestibular projections to the thalamus of the pigeon: an anatomical study.
    The Journal of comparative neurology, 1988, May-15, Volume: 271, Issue:3

    Topics: Animals; Autoradiography; Brain Mapping; Columbidae; Horseradish Peroxidase; Leucine; Proline; Thalamus; Vestibular Nuclei; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins

1988
Mediodorsal nucleus: areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys.
    The Journal of comparative neurology, 1988, Nov-08, Volume: 277, Issue:2

    Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Cerebral Cortex; Efferent Pathways; Female; Horseradish Peroxidase; Leucine; Macaca; Macaca mulatta; Male; Proline; Thalamus; Tritium; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins

1988
A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.
    The EMBO journal, 1989, Volume: 8, Issue:9

    Topics: Cells, Cultured; Cloning, Molecular; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; Fibroblasts; Genotype; Humans; Insulin Resistance; Leucine; Male; Mutation; Pedigree; Proline; Radioligand Assay; Receptor, Insulin

1989
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Neprilysin; Pain; Proline; Protease Inhibitors; Thiohydantoins; Thiorphan

1989
At least two mutant alleles of ornithine delta-aminotransferase cause gyrate atrophy of the choroid and retina in Finns.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:1

    Topics: Alleles; Arginine; Atrophy; Choroid; DNA; Female; Finland; Genes; Humans; Leucine; Male; Mutation; Ornithine-Oxo-Acid Transaminase; Pedigree; Proline; Retina; Retinal Degeneration; Threonine; Transaminases; Uveal Diseases

1989
Comparison of trigeminal receptor location and structure in the periodontal ligament of different types of teeth from the rat, cat, and monkey.
    The Journal of comparative neurology, 1989, Jan-01, Volume: 279, Issue:1

    Topics: Animals; Autoradiography; Cats; Haplorhini; Incisor; Leucine; Mechanoreceptors; Periodontal Ligament; Proline; Rats; Tooth; Trigeminal Nerve

1989
The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.
    The Journal of clinical investigation, 1989, Volume: 83, Issue:5

    Topics: Amino Acid Sequence; Antigens, Human Platelet; Base Sequence; DNA; Homozygote; Humans; Integrin beta3; Isoantigens; Leucine; Phenotype; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline

1989
Substitution of amino acids in helix F of bacteriorhodopsin: effects on the photochemical cycle.
    Biochemistry, 1989, Dec-26, Volume: 28, Issue:26

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Bacteriorhodopsins; Glutamates; Glutamic Acid; Glutamine; Glycine; Hydrogen Bonding; Kinetics; Leucine; Molecular Sequence Data; Mutation; Phenylalanine; Photochemistry; Proline; Protons; Serine; Tryptophan

1989
NMR studies of Arc repressor mutants: proton assignments, secondary structure, and long-range contacts for the thermostable proline-8----leucine variant of Arc.
    Biochemistry, 1989, Dec-12, Volume: 28, Issue:25

    Topics: Amino Acid Sequence; Electronic Data Processing; Leucine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Proline; Protein Conformation; Repressor Proteins; Salmonella Phages; Transcription Factors; Viral Proteins; Viral Regulatory and Accessory Proteins

1989
Retinal projection to mammalian telencephalon.
    Brain research, 1989, Jan-16, Volume: 477, Issue:1-2

    Topics: Animals; Autoradiography; Hypothalamus; Leucine; Mammals; Optic Nerve; Proline; Retina; Species Specificity; Telencephalon; Tritium; Visual Pathways

1989
The differentiation of normal and transformed human fibroblasts in vitro is influenced by electromagnetic fields.
    Experimental cell research, 1989, Volume: 182, Issue:2

    Topics: Cell Differentiation; Cell Line; Collagen; Electromagnetic Fields; Electromagnetic Phenomena; Fibroblasts; Humans; Leucine; Lung; Mitosis; Proline; Protein Biosynthesis; Proteins; Skin

1989
Pro----leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome.
    Biochemical and biophysical research communications, 1989, Sep-15, Volume: 163, Issue:2

    Topics: Alleles; DNA; Ethnicity; Genes, Viral; Humans; Leucine; Mutation; Nucleic Acid Hybridization; Polymorphism, Genetic; Prions; Proline; Slow Virus Diseases; Viral Proteins

1989
A Pro----Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI MHeerlen.
    Human genetics, 1989, Volume: 81, Issue:3

    Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Blotting, Southern; Codon; DNA; Exons; Female; Humans; Leucine; Male; Mutation; Pedigree; Phenotype; Proline; RNA, Messenger

1989
Hemoglobin Nouakchott [alpha 114(GH2)Pro----Leu]: a new hemoglobin variant displaying an unusual increase in hydrophobicity.
    Biochimica et biophysica acta, 1989, Sep-14, Volume: 998, Issue:1

    Topics: Adult; Amino Acid Sequence; Binding Sites; Electrophoresis; Female; Hemoglobins, Abnormal; Humans; Isoelectric Focusing; Leucine; Male; Middle Aged; Molecular Sequence Data; Oxygen; Peptides; Proline

1989
Thalamocortical connections of the rostral intralaminar nuclei: an autoradiographic analysis in the cat.
    The Journal of comparative neurology, 1989, Oct-22, Volume: 288, Issue:4

    Topics: Animals; Autoradiography; Cats; Cerebral Cortex; Leucine; Neural Pathways; Proline; Thalamic Nuclei

1989
Distribution of corticotectal axons from the caudal part of the anterior ectosylvian sulcus in the cat.
    Neuroscience letters, 1989, Jul-31, Volume: 102, Issue:2-3

    Topics: Animals; Axons; Brain Mapping; Cats; Cerebral Cortex; Leucine; Proline; Superior Colliculi

1989
A novel globin structural mutant, Showa-Yakushiji (beta 110 Leu-Pro) causing a beta-thalassemia phenotype.
    Blood, 1987, Volume: 70, Issue:5

    Topics: Amino Acid Sequence; Base Sequence; DNA Restriction Enzymes; Genes; Globins; Humans; Leucine; Mutation; Phenotype; Proline; Thalassemia

1987
Role of codon choice in the leader region of the ilvGMEDA operon of Serratia marcescens.
    Journal of bacteriology, 1987, Volume: 169, Issue:12

    Topics: Base Sequence; Codon; DNA Restriction Enzymes; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Leucine; Mutation; Operon; Plasmids; Proline; RNA, Messenger; Serratia marcescens; Transcription, Genetic

1987
Some extra-striate corticothalamic connections in macaque monkeys.
    Progress in brain research, 1988, Volume: 75

    Topics: Animals; Cerebral Cortex; Leucine; Macaca; Macaca fascicularis; Proline; Synaptic Transmission; Thalamus; Visual Pathways

1988
Effect of parathyroid hormone on amino acid transport by cultured neonatal mouse calvarial bone cells.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1988, Volume: 3, Issue:2

    Topics: Animals; Animals, Newborn; Biological Transport; Bucladesine; Cells, Cultured; Cycloheximide; Dactinomycin; Kinetics; Leucine; Mice; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Proline; Teriparatide

1988
Modulation of amino acid and 2-oxo acid pools in Trichomonas vaginalis by aspartate aminotransferase inhibitors.
    Molecular and biochemical parasitology, 1986, Volume: 21, Issue:1

    Topics: Alanine; Amino Acids; Amino Acids, Dicarboxylic; Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Culture Media; Glutamates; Glutamic Acid; Hydroxamic Acids; Leucine; Proline; Trichomonas vaginalis

1986
Comparison of the use of isotopic proline vs leucine to measure protein synthesis in cultured fibroblasts.
    Connective tissue research, 1986, Volume: 14, Issue:3

    Topics: Carbon Radioisotopes; Cell Line; Collagen; Culture Media; Embryo, Mammalian; Fibroblasts; Humans; Leucine; Proline; Protein Biosynthesis; RNA, Transfer, Amino Acyl; Tritium

1986
The effect of the intracellular sodium level on the activity of amino acid transport systems L and A in SV40 3T3 cells.
    Biochimica et biophysica acta, 1985, May-28, Volume: 815, Issue:3

    Topics: 3-O-Methylglucose; Animals; Biological Transport; Cell Transformation, Viral; Cells, Cultured; Kinetics; Leucine; Lithium; Methylglucosides; Mice; Phenylalanine; Proline; Simian virus 40; Sodium

1985
Effects of the putative neutrophil-generated toxin, hypochlorous acid, on membrane permeability and transport systems of Escherichia coli.
    The Journal of clinical investigation, 1986, Volume: 78, Issue:1

    Topics: beta-Galactosidase; Cell Membrane Permeability; Chloramines; Escherichia coli; Glutamine; Hypochlorous Acid; Leucine; Methylgalactosides; Neutrophils; Proline; Thiogalactosides; Toxins, Biological

1986
Cloning in Escherichia coli of genes involved in the synthesis of proline and leucine in Desulfovibrio desulfuricans Norway.
    Molecular & general genetics : MGG, 1987, Volume: 206, Issue:1

    Topics: Cloning, Molecular; Desulfovibrio; DNA Restriction Enzymes; Escherichia coli; Genes; Genes, Viral; Genetic Vectors; Leucine; Plasmids; Proline

1987
Antithrombin III Basel. Identification of a Pro-Leu substitution in a hereditary abnormal antithrombin with impaired heparin cofactor activity.
    The Journal of biological chemistry, 1986, Jan-25, Volume: 261, Issue:3

    Topics: Amino Acid Sequence; Antithrombin III; Chromatography, High Pressure Liquid; Humans; Isothiocyanates; Leucine; p-Dimethylaminoazobenzene; Peptide Fragments; Proline; Structure-Activity Relationship; Thiocyanates; Thiohydantoins; Trypsin

1986
Echinococcus granulosus: absorption of cycloleucine and alpha-aminoisobutyric acid by protoscoleces.
    Parasitology, 1986, Volume: 92 ( Pt 1)

    Topics: Absorption; Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cycloleucine; Diffusion; Echinococcus; Hydrogen-Ion Concentration; Leucine; Methionine; Proline; Serine; Valine

1986
Uptake pathways for amino acids in mouse intestine.
    The American journal of physiology, 1986, Volume: 251, Issue:4 Pt 1

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Intestinal Absorption; Jejunum; Kinetics; Leucine; Lysine; Male; Methionine; Mice; Proline; Sodium

1986
Further studies on the nutritional factors affecting the urinary excretion of acid-soluble peptides in rats.
    The British journal of nutrition, 1988, Volume: 60, Issue:2

    Topics: Aging; Amino Acids; Animals; Caseins; Dietary Proteins; Leucine; Lysine; Male; Methylhistidines; Nitrogen; Peptides; Proline; Rats; Rats, Inbred Strains; Tryptophan; Valine

1988
A topographic study of the course of nigral axons and of the distribution of pallidal axonal endings in the centre médian-parafascicular complex of macaques.
    Brain research, 1988, Nov-08, Volume: 473, Issue:1

    Topics: Animals; Autoradiography; Brain Mapping; Globus Pallidus; Leucine; Macaca; Nerve Endings; Neural Pathways; Proline; Substantia Nigra; Thalamic Nuclei

1988
Corticonigral projections from area 6 in the raccoon.
    Experimental brain research, 1988, Volume: 73, Issue:3

    Topics: Animals; Autoradiography; Brain Mapping; Cerebral Cortex; Leucine; Neural Pathways; Proline; Raccoons; Substantia Nigra

1988
A functional interaction between the signal peptide and the translation apparatus is detected by the use of a single point mutation which blocks translocation across mammalian endoplasmic reticulum.
    The Journal of biological chemistry, 1987, Jul-25, Volume: 262, Issue:21

    Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Endopeptidases; Endoplasmic Reticulum; Escherichia coli; Leucine; Membrane Proteins; Mutation; Plasmids; Proline; Protein Biosynthesis; Protein Sorting Signals; Serine Endopeptidases; Structure-Activity Relationship; Transcription, Genetic

1987
Retinal projections to the pretectum in the pigeon (Columba livia).
    The Journal of comparative neurology, 1988, Mar-01, Volume: 269, Issue:1

    Topics: Animals; Autoradiography; Brain Mapping; Columbidae; Eye; Female; Injections; Leucine; Male; Proline; Retina; Retinal Ganglion Cells; Superior Colliculi; Visual Pathways

1988
Corticothalamic connections of paralimbic regions in the rhesus monkey.
    The Journal of comparative neurology, 1988, Mar-01, Volume: 269, Issue:1

    Topics: Animals; Autoradiography; Brain Mapping; Cerebral Cortex; Leucine; Macaca; Macaca mulatta; Neural Pathways; Proline; Thalamus

1988
Nonretinal projections to the medial terminal accessory optic nucleus in rabbit and rat: a retrograde and anterograde transport study.
    The Journal of comparative neurology, 1988, Mar-01, Volume: 269, Issue:1

    Topics: Animals; Autoradiography; Brain Mapping; Horseradish Peroxidase; Leucine; Mesencephalon; Neural Pathways; Periaqueductal Gray; Proline; Rabbits; Rats; Superior Colliculi; Visual Pathways

1988
Bilateral pericruciate cortical innervation of the red nucleus in cats with adult or neonatal cerebral hemispherectomy.
    Brain research, 1988, Jun-21, Volume: 453, Issue:1-2

    Topics: Aging; Animals; Autoradiography; Cats; Cerebral Cortex; Cerebral Decortication; Female; Leucine; Male; Neural Pathways; Neuronal Plasticity; Proline; Red Nucleus

1988
Direct functional assessment of human osteoblasts by radioautography: methodology and application in end stage renal disease.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1988, Volume: 11, Issue:3

    Topics: Aluminum; Autoradiography; Biopsy; Bone and Bones; Cycloheximide; Female; Humans; Kidney Failure, Chronic; Leucine; Male; Middle Aged; Osteoblasts; Proline; Protein Biosynthesis; Reference Values; Tetracycline; Tritium

1988
Effects of prostaglandin E1 on collagen production and degradation in human fetal lung fibroblasts.
    Archives of biochemistry and biophysics, 1988, Volume: 265, Issue:2

    Topics: Alprostadil; Cell Line; Collagen; Fetus; Glycine; Humans; Hydroxyproline; Intracellular Membranes; Leucine; Lung; Proline

1988
The effect of prostaglandin E2 (PGE2) on amino acid uptake and protein formation by lung fibroblasts.
    The Journal of biological chemistry, 1986, Jul-05, Volume: 261, Issue:19

    Topics: Amino Acids; Aminoisobutyric Acids; Biological Transport; Cell Line; Dinoprostone; Fibroblasts; Humans; Kinetics; Leucine; Lung; Proline; Prostaglandins E; Protein Biosynthesis

1986
Differences in the efficiency and pattern of incorporation of [3H]leucine and [3H]proline into proteins of adult cat brain.
    Brain research, 1987, Jun-09, Volume: 413, Issue:1

    Topics: Animals; Autoradiography; Cats; Cell Membrane Permeability; Female; Leucine; Male; Medulla Oblongata; Molecular Weight; Nerve Tissue Proteins; Neuroglia; Neurons; Proline

1987
Autoradiographic study of the distribution of [3H]gamma-aminobutyrate-accumulating neural elements in guinea-pig intestine: evidence for a transmitter function of gamma-aminobutyrate.
    Neuroscience, 1986, Volume: 17, Issue:4

    Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Aminobutyrates; Animals; Autoradiography; Colon; Cyclohexanecarboxylic Acids; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; Leucine; Male; Myenteric Plexus; Neurons; Nipecotic Acids; Paraffin; Proline

1986
Posterior parietal projections to the intraparietal sulcus of the rhesus monkey.
    Experimental brain research, 1986, Volume: 62, Issue:3

    Topics: Animals; Brain Mapping; Leucine; Macaca mulatta; Microinjections; Neural Pathways; Parietal Lobe; Proline

1986
The effects of neonatal monocular enucleation on the organization of ipsilateral and contralateral retinothalamic projections in the rabbit.
    Brain research, 1986, Volume: 394, Issue:1

    Topics: Animals; Animals, Newborn; Autoradiography; Functional Laterality; Leucine; Neurons; Proline; Rabbits; Retina; Sensory Deprivation; Thalamus

1986
Amino acid catabolism in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus. 2. Metabolism of the carbon skeleton.
    Parasitology, 1986, Volume: 93 ( Pt 3)

    Topics: Amino Acids; Animals; Heligmosomatoidea; Isoleucine; Leucine; Liver; Nematoda; Nematospiroides dubius; Proline; Rats; Valine

1986
Comparison of olfactory bulb projections in pigeons and turtles.
    Brain, behavior and evolution, 1985, Volume: 27, Issue:1

    Topics: Animals; Autoradiography; Brain Mapping; Central Nervous System; Columbidae; Leucine; Olfactory Bulb; Olfactory Pathways; Proline; Species Specificity; Telencephalon; Turtles

1985
Mechanistic implications of the inhibition of peptidases by amino aldehydes and bestatin.
    Biochimica et biophysica acta, 1985, Jul-01, Volume: 829, Issue:3

    Topics: Alanine; Aldehydes; Aminopeptidases; Animals; Aspartic Acid Endopeptidases; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Kidney; Kinetics; Leucine; Leucyl Aminopeptidase; Male; Peptide Hydrolases; Proline; Protease Inhibitors; Rats; Testis

1985
Projections from the ventral respiratory group to phrenic and intercostal motoneurons in cat: an autoradiographic study.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:8

    Topics: Animals; Autoradiography; Axons; Biological Transport, Active; Cats; Intercostal Nerves; Leucine; Lysine; Motor Neurons; Phrenic Nerve; Proline; Respiration; Spinal Cord; Thoracic Nerves

1985
Mechanical stretching increases the number of cultured bone cells synthesizing DNA and alters their pattern of protein synthesis.
    Calcified tissue international, 1985, Volume: 37, Issue:4

    Topics: Animals; Animals, Newborn; Bone and Bones; Cells, Cultured; Collagen; DNA; DNA Replication; Leucine; Proline; Proteins; Rats; Stress, Mechanical; Thymidine; Tritium

1985
Is intestinal transport of sugars and amino acids subject to critical-period programming?
    The American journal of physiology, 1985, Volume: 249, Issue:6 Pt 1

    Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Body Weight; Carbohydrate Metabolism; Diet; Female; Glucose; Humans; Intestinal Mucosa; Intestine, Small; Intestines; Leucine; Lysine; Male; Mice; Potassium; Pregnancy; Proline

1985
Topography of occipital lobe commissural connections in the rhesus monkey.
    Brain research, 1986, Feb-12, Volume: 365, Issue:1

    Topics: Animals; Autoradiography; Corpus Callosum; Leucine; Macaca mulatta; Occipital Lobe; Proline; Visual Cortex; Visual Fields

1986
Kinetics of inhibition of rat liver and kidney arginases by proline and branched-chain amino acids.
    Biochimica et biophysica acta, 1986, Mar-28, Volume: 870, Issue:2

    Topics: Amino Acids, Branched-Chain; Animals; Arginase; Isoleucine; Kidney; Kinetics; Leucine; Liver; Proline; Rats; Valine

1986
An EM-autoradiographic and EM-HRP study of the commissural projection of the superior colliculus in the cat.
    The Journal of comparative neurology, 1985, Apr-01, Volume: 234, Issue:1

    Topics: Animals; Autoradiography; Cats; Horseradish Peroxidase; Leucine; Microscopy, Electron; Proline; Superior Colliculi; Synapses; Visual Pathways

1985
Stimulation of rat uterine collagen synthesis by relaxin.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 180, Issue:1

    Topics: Animals; Carbon Radioisotopes; Castration; Collagen; Diaphragm; Female; Kinetics; Leucine; Muscle, Smooth; Organ Size; Organ Specificity; Proline; Rats; Rats, Inbred Strains; Relaxin; Tritium; Uterus

1985
Increased dependence of leucine in posttraumatic sepsis: leucine/tyrosine clearance ratio as an indicator of hepatic impairment in septic multiple organ failure syndrome.
    Surgery, 1985, Volume: 98, Issue:3

    Topics: Adolescent; Adult; Alanine; Amino Acids; Amino Acids, Essential; Aspartic Acid; Glutamates; Humans; Leucine; Liver; Metabolic Clearance Rate; Multiple Organ Failure; Muscles; Proline; Sepsis; Tyrosine; Wounds and Injuries

1985
Quantitative analyses of axonal endings in the central nucleus of the inferior colliculus and distribution of 3H-labeling after injections in the dorsal cochlear nucleus.
    The Journal of comparative neurology, 1985, Jul-15, Volume: 237, Issue:3

    Topics: Animals; Axons; Biological Transport; Cats; Cochlear Nerve; Inferior Colliculi; Injections; Leucine; Microscopy, Electron; Proline; Synaptic Vesicles; Tissue Distribution; Tritium

1985
The thalamic relations of the caudal inferior parietal lobule and the lateral prefrontal cortex in monkeys: divergent cortical projections from cell clusters in the medial pulvinar nucleus.
    The Journal of comparative neurology, 1985, Nov-15, Volume: 241, Issue:3

    Topics: Animals; Autoradiography; Fluorescent Dyes; Frontal Lobe; Leucine; Macaca fascicularis; Neural Pathways; Parietal Lobe; Proline; Superior Colliculi; Thalamic Nuclei

1985
[Biosynthetic actinomycins from aurantin-producing Actynomyces].
    Antibiotiki, 1971, Volume: 16, Issue:1

    Topics: Actinomyces; Amino Acids; Antibiotics, Antineoplastic; Chromatography; Culture Media; Dactinomycin; Flavonoids; Isoleucine; Leucine; Oxidation-Reduction; Proline; Sarcosine; Threonine; Valine

1971
Components of fast and slow axonal transport in the goldfish optic nerve.
    Journal of neurobiology, 1971, Volume: 2, Issue:4

    Topics: Animals; Axonal Transport; Biological Transport, Active; Colchicine; Cyprinidae; Fucose; Glucosamine; Leucine; Nerve Tissue Proteins; Optic Nerve; Proline; Tectum Mesencephali; Tritium

1971
Effects of a nicotinamide-sensitive teratogen 6-aminonicotinamide on chick limb cells in culture.
    Experimental cell research, 1972, Volume: 70, Issue:1

    Topics: Abnormalities, Drug-Induced; Amines; Animals; Bone and Bones; Carbon Isotopes; Cartilage; Cells, Cultured; Chick Embryo; Culture Techniques; Ketones; Leucine; Mesoderm; Niacinamide; Proline; Pyridines; Staining and Labeling; Sulfates; Sulfur Isotopes; Thymidine; Tritium; Wings, Animal

1972
Neuroplasmic transport in the nervous system of the cockroach Periplaneta americana.
    Journal of neurobiology, 1971, Volume: 2, Issue:2

    Topics: Animals; Axonal Transport; Carbon Isotopes; Cockroaches; Cycloheximide; Ganglia; Leucine; Lysine; Microtubules; Models, Neurological; Nerve Tissue Proteins; Proline; Puromycin; Thymidine; Tritium; Uridine; Valine

1971
Transfer of material from efferent axons to sensory epithelium in the goldfish vestibular system.
    Brain research, 1972, Feb-25, Volume: 37, Issue:2

    Topics: Amino Acids; Animals; Arginine; Autoradiography; Axonal Transport; Cyprinidae; Epithelial Cells; Epithelium; Leucine; Lysine; Medulla Oblongata; Neurons, Efferent; Proline; Silver; Staining and Labeling; Tritium; Valine; Vestibule, Labyrinth; Vestibulocochlear Nerve

1972
Axonal transport of proteins in retinal ganglion cells. Amino acid incorporation into rapidly transported proteins and distribution of radioactivity to the lateral geniculate body and the superior colliculus.
    Brain research, 1972, Feb-25, Volume: 37, Issue:2

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axonal Transport; Cysteine; Female; Geniculate Bodies; Glycine; Histidine; Leucine; Lysine; Male; Methionine; Nerve Tissue Proteins; Optic Nerve; Phenylalanine; Proline; Rabbits; Retina; Superior Colliculi; Tritium; Tryptophan

1972
Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors.
    Brain research, 1972, Sep-15, Volume: 44, Issue:1

    Topics: Animals; Axonal Transport; Ganglia; Leucine; Mice; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Optic Nerve; Proline; Retina; Retinal Degeneration; Sensory Receptor Cells

1972
Methanolysis of the pyrrolidone ring of amino-terminal pyroglutamic acid in model peptides.
    Analytical biochemistry, 1972, Volume: 48, Issue:2

    Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Benzyl Compounds; Butanols; Chromatography, Gas; Crystallization; Esters; Hydrolysis; Isoleucine; Leucine; Lysine; Methanol; Peptides; Proline; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Serine; Staining and Labeling

1972
A retinohypothalamic projection in the rat.
    The Journal of comparative neurology, 1972, Volume: 146, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Dendrites; Female; Ganglia; Hypothalamus; Leucine; Male; Microscopy, Electron; Nerve Degeneration; Neural Pathways; Optic Chiasm; Optic Nerve; Proline; Rats; Retina

1972
Amino terminal sequences of mammalian type C RNA tumor virus group-specific antigens.
    Biochemical and biophysical research communications, 1972, Sep-26, Volume: 48, Issue:6

    Topics: Amino Acid Sequence; Animals; Antigens, Viral; Arginine; Autoanalysis; Cats; Chromatography, Gas; Chromatography, Gel; Chromatography, Thin Layer; Cross Reactions; Epitopes; Humans; Isoelectric Focusing; Leucine; Mice; Oncogenic Viruses; Proline; Retroviridae; RNA Viruses; Species Specificity; Viral Proteins

1972
Haemoglobin Southampton, 106 (G8) Leu leads to pro: an unstable variant producing severe haemolysis.
    Lancet (London, England), 1972, Dec-02, Volume: 2, Issue:7788

    Topics: Amino Acid Sequence; Anemia, Hemolytic; Child, Preschool; Female; Hemoglobins, Abnormal; Hemolysis; Heterozygote; Humans; Leucine; Mutation; Proline

1972
Transport of radioactivity from eye to visual cortex in the mouse.
    Experimental neurology, 1973, Volume: 39, Issue:1

    Topics: Action Potentials; Animals; Axonal Transport; Fucose; Geniculate Bodies; Glucosamine; Leucine; Mice; Nerve Tissue Proteins; Optic Nerve; Proline; Protein Precursors; Synaptic Transmission; Tritium; Visual Cortex

1973
Acetylcholine: fast axoplasmic transport in insect chemoreceptor fibers.
    Science (New York, N.Y.), 1973, Apr-20, Volume: 180, Issue:4083

    Topics: Acetylcholine; Animals; Autoradiography; Axonal Transport; Axons; Brain; Chemoreceptor Cells; Colchicine; Cytochalasin B; Insecta; Leucine; Proline; Tritium; Vinblastine

1973
Autoradiographic evidence for a direct retino-hypothalamic projection in the avian brain.
    Brain research, 1973, Apr-27, Volume: 53, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Birds; Columbidae; Hypothalamus; Leucine; Proline; Retina; Synaptic Transmission; Tritium

1973
Observations on the transport of radioactively labeled proteins in the visual system of the chick.
    Brain research, 1973, Jun-29, Volume: 56

    Topics: Animals; Autoradiography; Axonal Transport; Chickens; Leucine; Nerve Tissue Proteins; Neural Pathways; Optic Nerve; Proline; Retina; Superior Colliculi; Tritium; Visual Pathways

1973
Retinohypothalamic projection in mammals: a comparative study.
    Brain research, 1973, Jan-30, Volume: 49, Issue:2

    Topics: Anatomy, Comparative; Animals; Autoradiography; Axonal Transport; Haplorhini; Hedgehogs; Hypothalamus; Leucine; Macaca; Neural Pathways; Opossums; Proline; Retina; Shrews; Species Specificity; Tritium

1973
Regulation of subunit synthesis of Escherichia coli RNA polymerase.
    Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:9

    Topics: Carbon Radioisotopes; Cell-Free System; Coliphages; DNA-Directed RNA Polymerases; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Epitopes; Escherichia coli; Genetics, Microbial; Immunoassay; Leucine; Precipitin Tests; Proline; Templates, Genetic; Tritium

1973
Studies on the enzymes involved in the biosynthesis of cyclo-tris (N-2,3-dihydroxybenzoyl-L-seryl) in Escherichia coli: kinetic properties of the L-serine-activating enzyme.
    Journal of bacteriology, 1973, Volume: 116, Issue:2

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Anti-Bacterial Agents; Drug Stability; Enzyme Induction; Escherichia coli; Ethylmaleimide; Glycine; Gramicidin; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Phosphates; Phosphorus Radioisotopes; Proline; Serine; Threonine; Time Factors; Tritium; Tyrosine

1973
Axonal transport in growing and mature retinal ganglion cells.
    Brain research, 1973, Nov-23, Volume: 62, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Chick Embryo; Fucose; Ganglia; Leucine; Optic Nerve; Proline; Rabbits; Rats; Retina; Superior Colliculi; Tritium; Visual Pathways

1973
Differential uptake of (3H)proline and (3H)leucine by neurons: its importance for the autoradiographic tracing on pathways.
    Brain research, 1973, Nov-09, Volume: 62, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Cats; Cerebellum; Leucine; Neural Pathways; Neurons; Proline; Reticular Formation; Silver; Staining and Labeling; Tritium

1973
The use of affinity chromatography in determining the sites of protein-protein interaction relative to the binding sites of substrates in gramicidin S synthetase.
    European journal of biochemistry, 1973, Dec-03, Volume: 40, Issue:1

    Topics: Amino Acid Isomerases; Binding Sites; Chromatography, Affinity; Gramicidin; Leucine; Ligands; Multienzyme Complexes; Ornithine; Peptide Synthases; Phenylalanine; Polysaccharides; Proline; Valine

1973
Biochemical studies on gramicidin S non-producing mutants of Bacillus brevis ATCC 9999.
    Journal of biochemistry, 1974, Volume: 75, Issue:3

    Topics: Adenosine Triphosphate; Amino Acid Isomerases; Bacillus; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, Paper; Colorimetry; Gramicidin; Leucine; Multienzyme Complexes; Mutation; Nitrosoguanidines; Ornithine; Peptide Synthases; Proline; Radiation Effects; Ultraviolet Rays; Valine

1974
Dynamics of axoplasmic transport in the optic system of the rat.
    Experimental brain research, 1974, Volume: 21, Issue:1

    Topics: Alanine; Animals; Asparagine; Axonal Transport; Circadian Rhythm; Estrus; Female; Leucine; Male; Neurons; Pregnancy; Proline; Rats; Retina; Sex Factors; Solubility; Time Factors; Tritium; Visual Pathways

1974
An automated system for counting silver grains in autoradiographs.
    Brain research, 1974, Nov-29, Volume: 81, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Biological Transport, Active; Brain Mapping; Cerebral Cortex; Computers; Leucine; Microscopy; Neural Pathways; Proline; Rats; Silver; Television; Thalamic Nuclei; Tritium

1974
Anatomical analysis of pupillary reflex pathways in the rhesus monkey.
    The Journal of comparative neurology, 1974, Nov-15, Volume: 158, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Brain Mapping; Leucine; Light; Macaca mulatta; Mesencephalon; Neural Pathways; Oculomotor Nerve; Olivary Nucleus; Proline; Reflex, Pupillary; Superior Colliculi; Thalamic Nuclei; Tritium; Visual Pathways

1974
Axonal transport and turnover of proline- and leucine-labeled protein in the goldfish visual system.
    Journal of neurochemistry, 1974, Volume: 23, Issue:5

    Topics: Animals; Axonal Transport; Axons; Biological Transport; Blood Proteins; Brain; Carbon Radioisotopes; Eye Proteins; Goldfish; Half-Life; Kidney; Leucine; Microscopy, Electron; Nerve Tissue Proteins; Optic Nerve; Organ Specificity; Proline; Superior Colliculi; Time Factors; Tritium

1974
Allylglycine, and inhibitor of the uptake of L-leucine and L-proline in rat brain slices.
    Biochemical pharmacology, 1974, Feb-15, Volume: 23, Issue:4

    Topics: Allyl Compounds; Amino Acids; Animals; Benzenesulfonates; Brain; Carbon Radioisotopes; Catecholamines; Central Nervous System Stimulants; Chromatography, Ion Exchange; Chromatography, Thin Layer; Depression, Chemical; Dinitrophenols; Glutamates; Glycine; In Vitro Techniques; Iodoacetates; Kinetics; Leucine; Mercury; Methionine; Organometallic Compounds; Ouabain; Phenylalanine; Proline; Rats; Time Factors; Tritium; Valine

1974
Heterogeneity of membrane vesicles from Escherichia coli and their subfractionation with antibody to ATPase.
    Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:12

    Topics: Adenosine Triphosphatases; Antibodies; Antigen-Antibody Reactions; Bacterial Proteins; Cell Fractionation; Cell Membrane; Escherichia coli; Leucine; NADH, NADPH Oxidoreductases; Proline; Tritium

1974
Distinct components of neutral amino acid transport in chick small intestine.
    Comparative biochemistry and physiology. A, Comparative physiology, 1974, Feb-01, Volume: 47, Issue:2

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Chickens; Glycine; Intestinal Absorption; Intestine, Small; Leucine; Male; Proline; Tryptophan

1974
Nature of the gastric secretagogue in Zollinger-Ellison tumours.
    Lancet (London, England), 1967, Sep-09, Volume: 2, Issue:7515

    Topics: Alanine; Aspartic Acid; Gastrins; Glutamates; Glycine; Humans; In Vitro Techniques; Leucine; Methionine; Proline; Spectrum Analysis; Tryptophan; Tyrosine; Zollinger-Ellison Syndrome

1967
The position of various cleavages of rabbit immunoglobulin G.
    The Journal of biological chemistry, 1968, Apr-25, Volume: 243, Issue:8

    Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Bromine; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Cyanides; Cysteine; gamma-Globulins; Glutamates; Leucine; Lysine; Pepsin A; Proline; Rabbits; Serine; Sulfhydryl Compounds; Threonine; Trypsin

1968
Plasma-aminoacid levels in Huntington's chorea.
    Lancet (London, England), 1969, Apr-19, Volume: 1, Issue:7599

    Topics: Adult; Alanine; Amino Acids; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle Aged; Proline; Schizophrenia; Tyrosine; Valine

1969
Regulation of the -methylgalactoside transport system and the galatose-binding protein by the cell cycle of Escherichia coli.
    Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:5

    Topics: Alanine; Alkaline Phosphatase; Autoradiography; Bacterial Proteins; Carbon Isotopes; Cell Division; Culture Media; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Galactose; Galactosidases; Immunodiffusion; Lactose; Leucine; Mutation; Proline; Protein Binding; Temperature; Transduction, Genetic

1973
Hypothalamic releasing factors and Parkinson disease.
    Archives of neurology, 1974, Volume: 31, Issue:1

    Topics: Antiparkinson Agents; Depression, Chemical; Dihydroxyphenylalanine; Drug Therapy, Combination; Glycine; Humans; Leucine; Melanocyte-Stimulating Hormones; Oligopeptides; Parkinson Disease; Pituitary Hormone-Releasing Hormones; Proline; Thyrotropin-Releasing Hormone

1974
Studies on the inhibition of oxotremorine induced tremor by a melanocyte-stimulating hormone release-inhibiting factor, thyrotropin releasing hormone and related peptides.
    FEBS letters, 1974, Aug-15, Volume: 44, Issue:1

    Topics: Animals; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Glutamates; Glycine; Histidine; Leucine; Male; Melanocyte-Stimulating Hormones; Mice; Oligopeptides; Oxotremorine; Pituitary Hormone-Releasing Hormones; Proline; Structure-Activity Relationship; Temperature; Thyrotropin-Releasing Hormone; Tremor

1974
D-amino acids in the cell pool of bacteria.
    Folia microbiologica, 1974, Volume: 19, Issue:1

    Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Bacillus subtilis; Bacteria; Chromatography, Thin Layer; Clostridium; Culture Media; Escherichia coli; Glutamates; Histidine; Hydrogen-Ion Concentration; Lactobacillus; Leucine; Proline; Serine; Spectrophotometry; Staphylococcus; Stereoisomerism; Temperature; Tyrosine

1974
[Study of in vitro differentiation of mandibular molar tooth germs in mouse embryos].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1970, Sep-25, Volume: 164, Issue:2

    Topics: Alkaline Phosphatase; Animals; Autoradiography; Cell Differentiation; Culture Techniques; Histocytochemistry; Leucine; Mice; Mitosis; Molar; Proline; Thymidine; Time Factors; Tooth Germ; Tritium

1970
[Study of the action of dexamethasone phosphate on germs of mandibular molar tooth germs in mouse embryos cultivated in vitro].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1970, Sep-25, Volume: 164, Issue:2

    Topics: Alkaline Phosphatase; Animals; Autoradiography; Cell Differentiation; Culture Techniques; Dexamethasone; Histocytochemistry; Leucine; Mice; Mitosis; Molar; Proline; Thymidine; Time Factors; Tooth Germ; Tritium

1970
Preparation and properties of smooth muscle myosin from horse esophagus.
    Biochimica et biophysica acta, 1970, Sep-01, Volume: 216, Issue:2

    Topics: Adenosine Triphosphatases; Amino Acids; Animals; Asparagine; Aspartic Acid; Calcium; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Edetic Acid; Enzyme Activation; Esophagus; Ethylmaleimide; Glycine; Horses; Leucine; Lysine; Magnesium; Muscle Proteins; Muscle, Smooth; Muscles; Organ Specificity; Osmolar Concentration; Phosphorus; Potassium Chloride; Proline; Rabbits; Sulfhydryl Compounds; Temperature; Ultracentrifugation

1970
[Plasma amino acid levels in children of patients with Huntington's chorea].
    Neurology, 1972, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Alanine; Amino Acids; Child; Child, Preschool; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle Aged; Proline; Schizophrenia; Tyrosine

1972
The effects of the nicotinamide sensitive teratogen 3-acetylpyridine on chick limb mesodermal cells in culture: biochemical parameters.
    The Journal of experimental zoology, 1972, Volume: 180, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; DNA; Glycosaminoglycans; Ketones; Leucine; Limb Deformities, Congenital; Mesoderm; Muscles; Niacinamide; Phenotype; Proline; Pyridines; RNA; Thymidine; Tritium; Uridine

1972
Energization of active transport by Escherichia coli.
    The Journal of biological chemistry, 1972, Nov-25, Volume: 247, Issue:22

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Aerobiosis; Alanine; Anaerobiosis; Arsenic; Biological Transport, Active; Cell Membrane; Dinitrophenols; Energy Transfer; Escherichia coli; Glutamates; Lactates; Leucine; Oxidative Phosphorylation; Phosphoenolpyruvate; Proline

1972
Effects of cell density on the expression of differentiation by chick embryo chondrocytes.
    The Journal of experimental zoology, 1974, Volume: 187, Issue:3

    Topics: Animals; Cartilage; Cell Count; Cell Differentiation; Cells, Cultured; Chick Embryo; Collagen; Culture Media; Glycosaminoglycans; Histocytochemistry; Leucine; Methods; Proline; Protein Biosynthesis; Sulfur Radioisotopes; Time Factors; Tritium

1974
Association of axonally transported proteins with goldfish brain myelin fractions.
    Journal of neurochemistry, 1974, Volume: 23, Issue:2

    Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Axons; Biological Transport; Brain; Centrifugation, Density Gradient; Centrifugation, Zonal; Cyprinidae; Electrophoresis, Polyacrylamide Gel; Glycolipids; Goldfish; Kinetics; Leucine; Microscopy, Electron; Molecular Weight; Myelin Sheath; Nerve Tissue Proteins; Optic Nerve; Proline; RNA; Spectrophotometry, Ultraviolet; Time Factors; Tritium

1974
Intestinal adaptation in diabetes: amino acid absorption.
    The American journal of physiology, 1974, Volume: 227, Issue:4

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Chromatography, Paper; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glycine; Intestinal Absorption; Intestinal Mucosa; Leucine; Lysine; Male; Organ Size; Proline; Rats; Serous Membrane; Streptozocin; Time Factors

1974
Depression by hyaluronic acid of glycosaminoglycan synthesis by cultured chick embryo chondrocytes.
    Developmental biology, 1974, Volume: 41, Issue:2

    Topics: Animals; Bone Matrix; Carbon Radioisotopes; Cartilage; Cattle; Cell Differentiation; Cells, Cultured; Chick Embryo; Chondroitin; Collagen; Culture Media; Depression, Chemical; Glucosamine; Glycosaminoglycans; Hyaluronic Acid; Leucine; Monosaccharides; Oligosaccharides; Proline; Proteoglycans; Sulfates; Sulfur Radioisotopes; Thymidine; Time Factors

1974
The effects of L-azetidine-2-carboxylic acid (analogue of proline) on dental cytodifferentiations in vitro.
    Differentiation; research in biological diversity, 1974, Volume: 2, Issue:4

    Topics: Ameloblasts; Animals; Autoradiography; Azetidines; Azetines; Carbon Radioisotopes; Carboxylic Acids; Cell Differentiation; Cell Division; Collagen; Glycosaminoglycans; Leucine; Lysine; Mice; Microscopy, Electron; Odontoblasts; Proline; Tooth Germ; Tritium

1974
5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli.
    The Journal of biological chemistry, 1968, Jul-10, Volume: 243, Issue:13

    Topics: Adenine; Aspartic Acid; Escherichia coli; Glutamates; Glutamine; Glycine; Hydrogen-Ion Concentration; Leucine; Ligases; Peptides; Phosphoric Monoester Hydrolases; Proline; Spectrophotometry; Tyrosine; Venoms

1968
Primary structure of insoluble tendon collagen. II. N- and C-terminal positional analysis of collagenolytic breakdown products of trypsin-pretreated collagen.
    Archives of biochemistry and biophysics, 1968, Volume: 128, Issue:1

    Topics: Achilles Tendon; Alanine; Amino Acids; Animals; Arginine; Cattle; Collagen; Glycine; Hydroxyproline; Isoleucine; Leucine; Methionine; Methods; Microbial Collagenase; Phenylalanine; Proline; Threonine; Trypsin; Tyrosine

1968
Amino acid uptake in isolated chick embryo heart cells.
    The Biochemical journal, 1969, Volume: 114, Issue:1

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Chick Embryo; Glycine; Heart; Histidine; In Vitro Techniques; Insulin; Leucine; Methionine; Microbial Collagenase; Myocardium; Oxygen Consumption; Proline; Protein Biosynthesis; Serine; Threonine

1969
The effect of acute exercise on amino acid incorporation into mitochondria of rabbit tissues.
    Biochimica et biophysica acta, 1969, Aug-20, Volume: 186, Issue:2

    Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Aging; Amino Acids; Animals; Brain; Buffers; Carbon Isotopes; Centrifugation, Density Gradient; Hypoxia; Leucine; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen; Physical Exertion; Proline; Protein Biosynthesis; Quaternary Ammonium Compounds; Rabbits; Swimming; Testosterone

1969
Synthesis of corticotrophin-like polypeptides and protein by bovine hypothalamus, median eminence and pituitary tissue slices.
    The Journal of endocrinology, 1969, Volume: 44, Issue:4

    Topics: Adrenocorticotropic Hormone; Animals; Carboxypeptidases; Cattle; Chromatography; Chromatography, Gel; Hypothalamo-Hypophyseal System; Hypothalamus; In Vitro Techniques; Leucine; Molecular Weight; Peptide Biosynthesis; Phenylalanine; Pituitary Gland; Proline; Protein Biosynthesis

1969
Metabolic and virologic studies in primate liver organ cultures.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 133, Issue:3

    Topics: Animals; Autoradiography; Centrifugation, Density Gradient; Culture Techniques; DNA; Enterovirus; Haplorhini; Herpesviridae; Interferons; Leucine; Liver; Organ Culture Techniques; Orthomyxoviridae; Proline; Protein Biosynthesis; RNA; Thymidine; Tritium; Tyrosine; Uridine; Virus Replication

1970
Nonribosomal polypeptide synthesis: the biosynthesis of a cyclic peptide antibiotic, gramicidin S.
    Cold Spring Harbor symposia on quantitative biology, 1969, Volume: 34

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acid Sequence; Amino Acids; Bacillus; Chemical Precipitation; Chromatography, Gel; Diphosphates; Electrophoresis; Enzymes; Hydroxamic Acids; Leucine; Ligases; Models, Biological; Models, Structural; Ornithine; Peptide Biosynthesis; Peptides; Phenylalanine; Phosphorus Isotopes; Proline; Protein Denaturation; Ribosomes; Sulfhydryl Compounds; Trichloroacetic Acid; Tritium; Tyrothricin; Valine

1969
Biosynthesis of cyclic oligopeptide.
    Cold Spring Harbor symposia on quantitative biology, 1969, Volume: 34

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Bacillus; Carbon Isotopes; Chromatography, Ion Exchange; Depression, Chemical; Diphosphates; Enzymes; Filtration; Heterocyclic Compounds; Isomerases; Leucine; Ligases; Magnesium; Metabolism; Mutation; Peptide Biosynthesis; Phenylalanine; Piperazines; Proline; Protein Biosynthesis; Pyrophosphatases; Stimulation, Chemical; Tyrothricin

1969
Relationship of a membrane-bound D-(-)-lactic dehydrogenase to amino acid transport in isolated bacterial membrane preparations.
    Proceedings of the National Academy of Sciences of the United States of America, 1970, Volume: 66, Issue:3

    Topics: Acetates; Amino Acids; Biological Transport, Active; Butyrates; Carbon Isotopes; Citrates; Escherichia coli; Formates; Fumarates; Glyceric Acids; Hexosephosphates; Histidine; Hydroxybutyrates; Isoleucine; Ketoglutaric Acids; L-Lactate Dehydrogenase; Lactates; Leucine; Malates; Membranes; NAD; Oxaloacetates; Phenylalanine; Proline; Pyruvates; Stereoisomerism; Succinates; Thyroxine

1970
Cyclic AMP stimulation of amino acid uptake in bone and kidney.
    Biochimica et biophysica acta, 1970, Sep-15, Volume: 211, Issue:3

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Adenylyl Cyclases; Amino Acids; Aminoisobutyric Acids; Animals; Bone and Bones; Butyrates; Carbon Isotopes; Cyclic AMP; Enzyme Activation; Extracellular Space; Female; Fetus; Glycine; Guanine Nucleotides; In Vitro Techniques; Insulin; Kidney; Leucine; Male; Parathyroid Hormone; Pregnancy; Proline; Rats; Stimulation, Chemical; Time Factors

1970
Quantitative differences in proline tRNA content of rat liver and granulation tissue.
    Biochemical and biophysical research communications, 1970, Aug-11, Volume: 40, Issue:3

    Topics: Alanine; Albumins; Amino Acids; Animals; Carbon Isotopes; Chromatography; Granulation Tissue; Leucine; Liver; Male; Proline; Protein Biosynthesis; Rats; RNA, Transfer; Silicon Dioxide; Solubility; Tritium; Tyrosine

1970
[Biosynthesis of the basement membrane. Utilization of proline and glucose for the formation of components of the glomerular basement membrane in vitro].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1971, Volume: 268, Issue:1

    Topics: Animals; Basement Membrane; Carbon Isotopes; Cattle; Chromatography, Gel; Chromatography, Thin Layer; Cycloheximide; Depression, Chemical; Diuretics; Glucose; Glycine; Glycoproteins; Hydroxyproline; In Vitro Techniques; Kidney Glomerulus; Leucine; Microbial Collagenase; Peptide Hydrolases; Phlorhizin; Proline; Puromycin; Pyrazines; Rats

1971
[Chromophore substrates. 3. An improved method for the preparation of the colored colagenase substrate 4-phenylazobenzyl-oxycarbonyl-L-propyl-L-leucyl-glycyl-L-propyl-D-arginine].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1971, Volume: 352, Issue:10

    Topics: Arginine; Chemical Phenomena; Chemistry; Glycine; Leucine; Methods; Microbial Collagenase; Peptides; Proline

1971
Cyclic adenosine monophosphate-stimulated transport of amino acids in kidney cortex.
    The Journal of biological chemistry, 1972, Feb-10, Volume: 247, Issue:3

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Biological Transport, Active; Butyrates; Carbon Isotopes; Cyclic AMP; Cycloheximide; Glycine; Insulin; Kidney; Kinetics; Leucine; Lysine; Male; Ouabain; Parathyroid Hormone; Proline; Puromycin; Rats; Sodium; Vasopressins

1972
MSH-release-inhibiting factor: inactivation by proteolytic enzymes.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:2

    Topics: Aminopeptidases; Animals; Brain; Carboxypeptidases; Cattle; Cell Fractionation; Chymotrypsin; Endopeptidases; Glycine; Leucine; Leucyl Aminopeptidase; Male; Melanocyte-Stimulating Hormones; Methods; Microbial Collagenase; Peptide Hydrolases; Peptides; Proline; Rats; Swine; Thermolysin; Tissue Extracts

1972
Some mutants of Bacillus brevis deficient in gramicidin S formation.
    Biochemical and biophysical research communications, 1972, Jul-11, Volume: 48, Issue:1

    Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Bacillus; Carbon Isotopes; Carcinogens; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Diphosphates; Isomerases; Leucine; Mutation; Nitro Compounds; Nitrosoguanidines; Ornithine; Phenylalanine; Phosphorus Isotopes; Piperazines; Proline; Tyrothricin; Valine

1972
Influence of gonadotrophins and cyclic AMP on carbohydrate and protein metabolism in the immature rat ovary.
    Acta endocrinologica, 1973, Volume: 72, Issue:3

    Topics: Age Factors; Aminoisobutyric Acids; Animals; Carbon Isotopes; Cyclic AMP; Female; Follicle Stimulating Hormone; Glucose; In Vitro Techniques; Lactates; Leucine; Luteinizing Hormone; Ovary; Proline; Rats; Tritium

1973
Specificity of aeromonas aminopeptidase toward oligopeptides and polypeptides.
    European journal of biochemistry, 1973, May-02, Volume: 34, Issue:3

    Topics: Adrenocorticotropic Hormone; Aeromonas; Amides; Amino Acid Sequence; Amino Acids; Aminopeptidases; Autoanalysis; Electrophoresis, Paper; Glucagon; Hydrolysis; Insulin; Leucine; Oligopeptides; Peptides; Proline; Structure-Activity Relationship

1973
Hemoglobin Abraham Lincoln, beta32 (B14) leucine leads to proline. An unstable variant producing severe hemolytic disease.
    The Journal of clinical investigation, 1973, Volume: 52, Issue:7

    Topics: Adult; Amino Acids; Anemia, Hemolytic; Carbon Isotopes; Carbon Monoxide; Chemical Precipitation; Chromatography, Ion Exchange; Chromium Isotopes; Electrophoresis; Erythrocytes; Female; Half-Life; Heme; Hemoglobins, Abnormal; Hot Temperature; Humans; Hydroxymercuribenzoates; Inclusion Bodies; Leucine; Methemoglobin; Proline; Reticulocytes; Sulfites

1973
Inactivation of melanocyte-stimulating hormone release-inhibiting factor by a manganese-stimulated bovine brain aminopeptidase.
    The Journal of biological chemistry, 1973, Aug-25, Volume: 248, Issue:16

    Topics: Aminopeptidases; Angiotensin II; Animals; Bradykinin; Brain; Cattle; Glycine; Kidney; Leucine; Leucyl Aminopeptidase; Luteinizing Hormone; Manganese; Melanocyte-Stimulating Hormones; Oligopeptides; Oxytocin; Pituitary Hormone-Releasing Hormones; Proline; Structure-Activity Relationship; Swine; Thyrotropin-Releasing Hormone; Vasotocin

1973
Protein and glycoprotein subunit composition of plasma membrane from chick embryo fibroblasts.
    The Journal of biological chemistry, 1974, Feb-25, Volume: 249, Issue:4

    Topics: Animals; Carbon Radioisotopes; Cell Membrane; Chick Embryo; Electrophoresis, Disc; Fibroblasts; Glucosamine; Glycoproteins; Hexosamines; Iodine Radioisotopes; Leucine; Macromolecular Substances; Microbial Collagenase; Molecular Weight; Peptides; Periodic Acid; Proline; Protein Biosynthesis; Proteins; Sodium Dodecyl Sulfate; Tritium

1974
Protein synthesis and secretion in a myogenic cell line.
    Developmental biology, 1973, Volume: 33, Issue:1

    Topics: Animals; Carbon Radioisotopes; Cell Differentiation; Cell Line; Clone Cells; Collagen; Creatine Kinase; Electrophoresis, Polyacrylamide Gel; Hydroxyproline; In Vitro Techniques; Leucine; Muscle Proteins; Muscles; Myofibrils; Myosins; Phosphotransferases; Proline; Rats; Time Factors; Tritium

1973
Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.
    Journal of cellular physiology, 1974, Volume: 83, Issue:3

    Topics: Amino Acids; Animals; Arginine; Asparagine; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Culture Media; Cycloheximide; Drug Synergism; Glutamine; Glycine; Immune Sera; Leucine; Liver Neoplasms; Neoplasm Proteins; Ornithine; Proline; Pyridoxal; Rats; Serine; Stimulation, Chemical; Time Factors

1974
Radical yield in X-irradiated biological molecules. II. Naturally-occurring amino-acids.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1974, Volume: 25, Issue:5

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamates; Histamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Valine

1974
Iontophoretic and autoradiographic studies on the role of proline in nervous transmission.
    Pflugers Archiv : European journal of physiology, 1974, Volume: 350, Issue:2

    Topics: Alkaloids; Animals; Autoradiography; Cats; Cerebellar Cortex; Dioxoles; Iontophoresis; Isoquinolines; Leucine; Methods; Proline; Purkinje Cells; Strychnine; Synaptic Transmission; Tritium

1974
Inhibitory effect of complex formation with oligodeoxyribonucleotide ethyl phosphotriesters on transfer ribonucleic acid aminoacylation.
    Biochemistry, 1974, Nov-19, Volume: 13, Issue:24

    Topics: Amino Acyl-tRNA Synthetases; Anticodon; Base Sequence; Binding Sites; Deoxyribonucleotides; Diphosphates; Escherichia coli; Kinetics; Leucine; Lysine; Oligonucleotides; Phenylalanine; Phosphorus Radioisotopes; Proline; Protein Binding; RNA, Bacterial; RNA, Transfer; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Time Factors; Tritium; Tyrosine

1974
Amino acid sequence of an alkaline proteinase inhibitor (Streptomyces subtilisin inhibitor) from Streptomyces albogriseolus S-3253.
    Journal of biochemistry, 1974, Volume: 76, Issue:6

    Topics: Alanine; Amino Acid Sequence; Chymotrypsin; Cyanogen Bromide; Leucine; Methylation; Microbial Collagenase; Proline; Streptomyces; Subtilisins; Thermolysin; Threonine; Trypsin; Trypsin Inhibitors

1974
[Further studies on amino acid sequence of proteins in tobacco mosaic virus].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1965, Volume: 20, Issue:12

    Topics: Alanine; Amino Acid Sequence; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Chromatography, Paper; Electrophoresis; Glutamates; Leucine; Peptides; Proline; Threonine; Tobacco Mosaic Virus; Valine; Viral Proteins

1965
[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine in the induction of mutation. I. Effect of 1-nitroso-3-nitro-1-methylguanidine on the template activity of polyncleotides in cell-free protein synthesis].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1967, Volume: 22, Issue:5

    Topics: Adenine Nucleotides; Amino Acids; Bacterial Proteins; Cell-Free System; Cytosine Nucleotides; Escherichia coli; Guanidines; Guanine Nucleotides; Leucine; Lysine; Molecular Biology; Mutagens; Mutation; Nitroso Compounds; Phenylalanine; Polynucleotides; Proline; Ribosomes; RNA, Bacterial; RNA, Transfer; Serine; Templates, Genetic; Tritium; Uracil Nucleotides

1967
Thermal denaturation equilibria of TMV coat proteins with chemically defined differences in their primary structure.
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1969, Volume: 24, Issue:5

    Topics: Genetics, Microbial; Hot Temperature; Kinetics; Leucine; Mutation; Optical Rotatory Dispersion; Proline; Protein Denaturation; Spectrophotometry; Tobacco Mosaic Virus; Ultracentrifugation; Ultraviolet Rays; Viral Proteins

1969
Kinetic behavior of D-amino acid oxidase in its reaction with basic amino acids.
    Journal of biochemistry, 1970, Volume: 67, Issue:1

    Topics: Alanine; Amino Acids; Arginine; D-Amino-Acid Oxidase; In Vitro Techniques; Kinetics; Leucine; Phenylalanine; Proline; Valine

1970
Release of alpha imino acid as primary product in D-amino-acid oxidase reaction.
    Biochimica et biophysica acta, 1970, Aug-15, Volume: 212, Issue:2

    Topics: Alanine; Chemical Phenomena; Chemistry; D-Amino-Acid Oxidase; Hydrogen-Ion Concentration; Imines; Leucine; Oxygen Consumption; Proline

1970
Fluorometric assay of amino acids.
    Analytical biochemistry, 1968, Oct-10, Volume: 26, Issue:1

    Topics: Amino Acid Oxidoreductases; Amino Acids; Arginine; Benzoates; D-Amino-Acid Oxidase; Fluorometry; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leucine; Methionine; Methods; Phenylacetates; Phenylalanine; Proline; Stereoisomerism; Tryptophan; Tyrosine

1968
Isolation and structure of hypothalamic MSH release-inhibition hormone.
    Biochemical and biophysical research communications, 1971, Jun-18, Volume: 43, Issue:6

    Topics: Amides; Amino Acid Sequence; Amino Acids; Animals; Anura; Biological Assay; Carbon Isotopes; Cattle; Chromatography, Gel; Chromatography, Thin Layer; Depression, Chemical; Electrophoresis; Fluorescence; Glycine; Hypothalamus; Isomerism; Leucine; Mass Spectrometry; Melanocyte-Stimulating Hormones; Neurotransmitter Agents; Peptides; Pituitary Hormone-Releasing Hormones; Proline; Skin; Sulfonic Acids; Thiocyanates; Ultraviolet Rays

1971
Mutant strains of Escherichia coli K12 that use D-amino acids.
    Proceedings of the National Academy of Sciences of the United States of America, 1971, Volume: 68, Issue:10

    Topics: Amino Acids; Arginine; Chromosome Mapping; Coliphages; D-Amino-Acid Oxidase; Escherichia coli; Genetic Linkage; Genotype; Histidine; Isoleucine; Isomerism; Leucine; Lysine; Mutation; Phenylalanine; Proline; Serine; Threonine; Transduction, Genetic; Tryptophan; Tyrosine; Valine

1971
Thin-layer chromatographic determination of the optical purity of labeled amino acids via dipeptide formation.
    Analytical biochemistry, 1972, Volume: 49, Issue:2

    Topics: Amino Acids; Anhydrides; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; D-Amino-Acid Oxidase; Densitometry; Dipeptides; Leucine; Methods; Proline; Stereoisomerism; Tritium

1972
A distinct component of proline transport in chicken small intestine.
    Comparative biochemistry and physiology. A, Comparative physiology, 1972, Jun-01, Volume: 42, Issue:2

    Topics: Animals; Biological Transport; Chickens; Female; Glycine; Intestinal Absorption; Intestine, Small; Leucine; Proline

1972
Protein and peptide hydrolases of the rat hypothalamus and pituitary.
    Journal of neurochemistry, 1974, Volume: 22, Issue:5

    Topics: Aminopeptidases; Animals; Cerebral Cortex; Dipeptides; Endopeptidases; Glycine; Hemoglobins; Hypothalamus; Kinetics; Leucine; Male; Oligopeptides; Organ Specificity; Peptide Hydrolases; Pituitary Gland; Pituitary Gland, Posterior; Pituitary Hormones; Proline; Structure-Activity Relationship

1974
In vitro studies on the uptake and incorporation of natural amino acids in rabbit choroid plexus.
    Brain research, 1974, Jun-14, Volume: 73, Issue:1

    Topics: Absorption; Amino Acids; Animals; Biological Transport; Carbon Radioisotopes; Chloramphenicol; Choroid Plexus; Cycloheximide; Glutamates; Glycine; Histidine; Inulin; Isoleucine; Kinetics; Leucine; Osmotic Pressure; Phenylalanine; Proline; Puromycin; Rabbits; Tritium; Tyrosine

1974
Action of insulin on amino acid uptake by the immature rat uterus in vitro.
    Biochimica et biophysica acta, 1974, Sep-06, Volume: 363, Issue:2

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Radioisotopes; Cattle; Choline; Ethylmaleimide; Female; Glycine; Insulin; Kinetics; Leucine; Methionine; Proline; Puromycin; Rats; Receptors, Drug; Sodium; Time Factors; Uterus; Valine

1974
An autoradiographic study of the efferent connections of the ventral lateral geniculate nucleus in the albino rat and the cat.
    The Journal of comparative neurology, 1974, Volume: 156, Issue:2

    Topics: Animals; Autoradiography; Brain Mapping; Cats; Geniculate Bodies; Hypothalamus; Leucine; Neural Pathways; Neurons; Neurons, Efferent; Proline; Rats; Retina; Species Specificity; Superior Colliculi; Tritium; Visual Cortex; Visual Pathways

1974
An autoradiographic study of the projections of the dorsal lateral geniculate nucleus and the posterior nucleus in the cat.
    Brain research, 1974, Nov-08, Volume: 80, Issue:1

    Topics: Animals; Autoradiography; Cats; Cerebral Cortex; Geniculate Bodies; Hypothalamus; Leucine; Proline; Thalamic Nuclei; Tritium

1974
Metabolism of L-azetidine-2-carboxylic acid in the alga Cyanidium caldarium.
    Biochimica et biophysica acta, 1974, Oct-28, Volume: 366, Issue:3

    Topics: Azetidines; Azetines; Carbon Radioisotopes; Chlorophyll; Darkness; Eukaryota; Imino Acids; Leucine; Pigments, Biological; Plant Proteins; Proline; Spectrophotometry, Ultraviolet; Subcellular Fractions; Time Factors; Ultracentrifugation; Ultrasonics

1974
Amino acid transport in human placental slices.
    American journal of obstetrics and gynecology, 1974, Dec-15, Volume: 120, Issue:8

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Biological Transport, Active; Carbon Radioisotopes; Chromatography, Paper; Extracellular Space; Female; Glutamates; Glycine; Humans; In Vitro Techniques; Kidney; Leucine; Lysine; Placenta; Pregnancy; Proline; Rats; Serine; Time Factors

1974
Involvement of glutamate in memory formation.
    Brain research, 1974, Dec-13, Volume: 81, Issue:3

    Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Chickens; Conditioning, Classical; Electroencephalography; Glutamates; Glutamine; Injections, Intraperitoneal; Injections, Intravenous; Isoleucine; Leucine; Memory; Memory, Short-Term; Proline

1974
Free amino acid levels in the boll weevil (Coleoptera: Curculionidae): the effect of five different diets.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1974, Dec-15, Volume: 49, Issue:4

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chromatography, Gas; Coleoptera; Diet; Dietary Proteins; Glutamates; Glycine; Gossypium; Histidine; Isoleucine; Leucine; Male; Mass Spectrometry; Methionine; Phenylalanine; Proline; Threonine; Tryptophan; Tyrosine; Valine

1974
Protein synthesis in vitro by the rat brain in course of experimental cyanide encephalopathy.
    Experimentelle Pathologie, 1974, Volume: 9, Issue:3

    Topics: Animals; Brain; Brain Diseases; Cyanides; Demyelinating Diseases; Disease Models, Animal; Female; Hypoxia; Leucine; Male; Myelin Sheath; Nerve Tissue Proteins; Poisoning; Proline; Rats

1974
The far-infrared properties of polyamino acids.
    Biopolymers, 1974, Volume: 13, Issue:12

    Topics: Absorption; Alanine; Amino Acid Sequence; Amino Acids; Caseins; Leucine; Mathematics; Myoglobin; Oligopeptides; Ovalbumin; Peptides; Proline; Solutions; Solvents; Spectrophotometry, Infrared; Temperature

1974
Free amino acids in the haemocytes and plasma of the larva of Calliphora vicina.
    The Journal of experimental biology, 1974, Volume: 61, Issue:2

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Blood Cells; Blood Coagulation; Diptera; Glutamates; Glutamine; Glycine; Hemolymph; Histidine; Isoleucine; Larva; Leucine; Lysine; Methionine; Phenylalanine; Plasma; Proline; Serine; Taurine; Threonine; Tyrosine; Valine

1974
Study of serum amino acids in Egyptian lead workers.
    The Journal of the Egyptian Medical Association, 1974, Volume: 57, Issue:1-2

    Topics: Adult; Alanine; Amino Acids; Colorimetry; Egypt; Glutamates; Glycine; Histidine; Humans; Lead Poisoning; Leucine; Lysine; Male; Middle Aged; Proline; Serine; Tyrosine; Valine

1974
The structural code for proteins: zonal distribution of amino acid residues and stabilization of helices by hydrophobic triplets.
    Journal of molecular biology, 1974, Sep-15, Volume: 88, Issue:2

    Topics: Alanine; Amino Acids; Aspartic Acid; Computers; Isoleucine; Leucine; Mathematics; Models, Molecular; Proline; Protein Conformation; Statistics as Topic; Tyrosine; Valine

1974
Experiments on the origin of molecular chirality by parity non-conservation during beta-decay.
    Journal of molecular evolution, 1974, Nov-28, Volume: 4, Issue:1

    Topics: Leucine; Norleucine; Optical Rotation; Proline; Radiation Effects; Stereoisomerism; Strontium Radioisotopes; Tyrosine; Valine; Yttrium Radioisotopes

1974
Prebiotic synthesis of hydrophobic and protein amino acids.
    Proceedings of the National Academy of Sciences of the United States of America, 1972, Volume: 69, Issue:3

    Topics: Alanine; Amino Acids; Aminobutyrates; Aminoisobutyric Acids; Ammonia; Aspartic Acid; Autoanalysis; Chromatography, Gas; Glutamates; Glycine; Isoleucine; Leucine; Mass Spectrometry; Methane; Nitrogen; Proline; Serine; Threonine; Valine; Water

1972
Specific glycine--accumulating synaptosomes in the spinal cord of rats.
    Proceedings of the National Academy of Sciences of the United States of America, 1972, Volume: 69, Issue:11

    Topics: Aminobutyrates; Animals; Arginine; Aspartic Acid; Brain Stem; Carbon Isotopes; Cell Fractionation; Centrifugation, Density Gradient; Cerebral Cortex; Glutamates; Glycine; Leucine; Lysine; Male; Nerve Endings; Proline; Rats; Spinal Cord; Subcellular Fractions; Synaptic Vesicles; Synaptosomes; Threonine; Tritium; Tyrosine

1972
Accumulation and transport of amino acids by the frog choroid plexus.
    Brain research, 1972, Sep-15, Volume: 44, Issue:1

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Anura; Biological Transport, Active; Carbon Isotopes; Choroid Plexus; Glutamates; Glycine; Inulin; Leucine; Mannitol; Potassium; Proline; Rana catesbeiana; Sodium

1972
Evidence that Pro-Leu-Gly-NH 2 , tocinoic acid, and des-Cys-tocinoic acid do not affect secretion of melanocyte stimulating hormone.
    Biochemical and biophysical research communications, 1973, Mar-05, Volume: 51, Issue:1

    Topics: Amino Acid Sequence; Animals; Anura; Cells, Cultured; Chromatography, Thin Layer; Cystine; Disulfides; Glycine; In Vitro Techniques; Leucine; Male; Melanocyte-Stimulating Hormones; Oxytocin; Peptides, Cyclic; Pituitary Gland; Proline; Rana pipiens; Rats; Skin

1973
Autoradiographic demonstration of optic nerve fibers in the stratum zonale of the frog's tectum.
    Brain research, 1973, Aug-30, Volume: 58, Issue:2

    Topics: Animals; Anura; Autoradiography; Leucine; Optic Nerve; Proline; Rana pipiens; Superior Colliculi; Thalamus; Tritium

1973
Messenger activity of nuclear RNA of frog embryos.
    Experimental cell research, 1974, Volume: 89, Issue:2

    Topics: Animals; Cell Nucleus; Female; Leucine; Microinjections; Ovum; Proline; Protein Biosynthesis; Rana pipiens; RNA, Messenger; Templates, Genetic; Time Factors; Tritium; Xenopus

1974
Recombination in Escherichia coli. V. Genetic analysis of recombinants from crosses with recipients deficient in ATP-dependent exonuclease activity.
    Mutation research, 1972, Volume: 14, Issue:4

    Topics: Adenosine Triphosphate; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Crosses, Genetic; Deoxyribonucleases; Drug Resistance, Microbial; Escherichia coli; Genetic Linkage; Leucine; Mathematics; Probability; Proline; Recombination, Genetic; Streptomycin; Threonine; Thymine; Time Factors; Transduction, Genetic

1972
Syntheses and LH- and FSH-RH activities of LH-RH analogs substituted at position 8.
    Biochemical and biophysical research communications, 1972, Dec-04, Volume: 49, Issue:5

    Topics: Animals; Biological Assay; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Female; Follicle Stimulating Hormone; Glycine; Leucine; Luteinizing Hormone; Methods; Ovary; Pituitary Hormone-Releasing Hormones; Proline; Radioimmunoassay; Rats; Structure-Activity Relationship; Swine

1972
Structure of a hypothalamic peptide possessing gonadotropin-releasing activity.
    International journal of peptide and protein research, 1972, Volume: 4, Issue:6

    Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Carbon Isotopes; Glutamates; Glycine; Gonadotropins; Histidine; Hypothalamus; Leucine; Mass Spectrometry; Peptide Chain Termination, Translational; Pituitary Hormone-Releasing Hormones; Proline; Serine; Swine; Tryptophan; Tyrosine

1972
Synthesis and biological activities of analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 1 or 2.
    Biochemical and biophysical research communications, 1973, Mar-05, Volume: 51, Issue:1

    Topics: Animals; Castration; Female; Glutamates; Glycine; Leucine; Luteinizing Hormone; Ovary; Peptide Chain Elongation, Translational; Phenylalanine; Pituitary Hormone-Releasing Hormones; Proline; Rats; Serine; Structure-Activity Relationship

1973
General activity in intact and hypophysectomized rats after administration of melanocyte-stimulating hormone (MSH), melatonin, and PRO-LEU-GLY-NH 2 .
    Physiology & behavior, 1973, Volume: 10, Issue:2

    Topics: Animals; Glycine; Hypophysectomy; Leucine; Locomotion; Male; Melanocyte-Stimulating Hormones; Melatonin; Motor Activity; Oligopeptides; Peptides; Pituitary Gland; Pituitary Hormone-Releasing Hormones; Proline; Rats

1973
Abnormal excision and transfer of chromosomal segments by a strain of Escherichia coli K-12.
    Journal of bacteriology, 1972, Volume: 111, Issue:1

    Topics: Acridines; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Crosses, Genetic; DNA Replication; Escherichia coli; Galactose; Genes; Genetic Linkage; Leucine; Mutation; Proline; Recombination, Genetic; Temperature; Threonine; Xylose

1972
Effects of proline analogues on the formation of alkaline phosphatase in Escherichia coli.
    Journal of bacteriology, 1972, Volume: 111, Issue:1

    Topics: Alkaline Phosphatase; Amino Acids; Bacterial Proteins; Carbon Radioisotopes; Cell Membrane; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Leucine; Mutation; Proline; Spheroplasts; Tritium

1972
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation.
    Acta endocrinologica, 1974, Volume: 75, Issue:1

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, Thin Layer; Dansyl Compounds; Diabetes Mellitus; Fasting; Female; Freeze Drying; Glutamates; Glycine; Islets of Langerhans; Leucine; Lysine; Mice; Obesity; Ornithine; Phenylalanine; Proline; Taurine; Tritium; Valine

1974
Activity of polypeptide chain initiation factors during a nutritional shift-up in Escherichia coli.
    Biochemical and biophysical research communications, 1974, Mar-15, Volume: 57, Issue:1

    Topics: Acetates; Amino Acids; Carbon Radioisotopes; Cell Division; Chromatography, Gel; Coliphages; Escherichia coli; Glucose; Leucine; Methionine; Mutation; Nucleosides; Peptide Initiation Factors; Proline; Protein Biosynthesis; RNA, Messenger; RNA, Transfer; RNA, Viral; Spectrophotometry; Time Factors; Tritium; Viral Proteins

1974
[Effect of inhibitors of protein and nucleic acid synthesis on the form of the nucleoid of Escherichia coli].
    Zeitschrift fur allgemeine Mikrobiologie, 1974, Volume: 14, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbon Radioisotopes; Cell Nucleus; Centrifugation, Density Gradient; DNA, Bacterial; Escherichia coli; Leucine; Microscopy, Electron; Proline; RNA, Bacterial; Thymidine; Transcription, Genetic; Tritium; Uridine; Valine

1974
Evolution of a new gene substituting for the leuD gene of Salmonella typhimurium: characterization of supQ mutations.
    Journal of bacteriology, 1974, Volume: 119, Issue:3

    Topics: Chromosome Mapping; Crosses, Genetic; Dicarboxylic Acids; Genes; Isomerases; Leucine; Models, Biological; Mutagens; Mutation; Nitrites; Proline; Salmonella; Salmonella typhimurium; Suppression, Genetic; Temperature; Transduction, Genetic; Valerates

1974
Studies on T4-tRNA biosynthesis: accumulation of precursor tRNA molecules in a temperature sensitive mutant of Escherichia coli.
    FEBS letters, 1974, Apr-01, Volume: 40, Issue:2

    Topics: Base Sequence; Coliphages; Densitometry; Drug Stability; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glycine; Leucine; Mutation; Phosphorus Radioisotopes; Proline; Ribonucleases; Ribonucleotides; RNA, Transfer; RNA, Viral; Serine; Temperature; Time Factors; Transcription, Genetic; Virus Replication

1974
Basis of transport discrimination of arginine from other basic amino acids in Salmonella typhimurium.
    The Journal of biological chemistry, 1974, Nov-10, Volume: 249, Issue:21

    Topics: Alanine; Amino Acids; Arginine; Autoanalysis; Biological Transport; Carbon Radioisotopes; Chromatography, Ion Exchange; Deuterium; Glucose; Histidine; Homoserine; Hydroxyproline; Kinetics; Leucine; Lysine; Magnetic Resonance Spectroscopy; Mathematics; Ornithine; Proline; Salmonella typhimurium; Structure-Activity Relationship; Tritium; Tryptophan

1974
Evolution of a new gene substituting for the leuD gene of Salmonella typhimurium: origin and nature of supQ and newD mutations.
    Journal of bacteriology, 1974, Volume: 120, Issue:3

    Topics: Adenine; Chromosome Mapping; Crosses, Genetic; Genes; Genetic Linkage; Leucine; Lysogeny; Models, Biological; Mutagens; Mutation; Nitrosoguanidines; Proline; Salmonella Phages; Salmonella typhimurium; Transduction, Genetic

1974
An autoradiographic and electron microscopic study of retino-hypothalamic connections.
    Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948), 1972, Volume: 135, Issue:1

    Topics: Animals; Autoradiography; Axons; Cats; Dendrites; Glycogen; Guinea Pigs; Haplorhini; Hypothalamus; Leucine; Macaca; Microscopy; Microscopy, Electron; Mitochondria; Neurosecretion; Proline; Rabbits; Rats; Retina; Synapses; Synaptic Vesicles; Tritium

1972
[Amino acids in parenteral feeding].
    Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa, 1972, Volume: 13

    Topics: Alanine; Amino Acids; Arginine; Histidine; Homeostasis; Humans; Isoleucine; Leucine; Lysine; Male; Methionine; Nutrition Disorders; Parenteral Nutrition; Phenylalanine; Proline; Protein Conformation; Protein-Energy Malnutrition; Proteins; Threonine; Tryptophan; Valine

1972
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
    Neuroendocrinology, 1973, Volume: 11, Issue:1

    Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine; Haplorhini; Humans; Injections, Intraperitoneal; Leucine; Mice; Oligopeptides; Pargyline; Proline; Reserpine; Secologanin Tryptamine Alkaloids

1973
A strong competitive peptide-inhibitor for leucine aminopeptidase.
    FEBS letters, 1972, Jun-15, Volume: 23, Issue:2

    Topics: Anilides; Calcitonin; Chemical Phenomena; Chemistry; Humans; Hydrolysis; Leucine; Leucyl Aminopeptidase; Ligands; Magnetic Resonance Spectroscopy; Nitro Compounds; Peptides; Phenylalanine; Proline; Protons; Spectrum Analysis; Threonine

1972
Preliminary clinical studies with L-prolyl-L-leucyl-glycine amide in Parkinson's disease.
    Canadian Medical Association journal, 1972, Dec-09, Volume: 107, Issue:11

    Topics: Administration, Oral; Aged; Amides; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Glycine; Humans; Injections, Intravenous; Leucine; Male; Middle Aged; Movement Disorders; Parkinson Disease; Peptides; Proline

1972
The chemical composition of wool. XI. Separation and analysis of exocuticle and endocuticle.
    Australian journal of biological sciences, 1972, Volume: 25, Issue:6

    Topics: Amino Acids; Animals; Aspartic Acid; Coloring Agents; Cysteine; Cystine; Formates; Histidine; Leucine; Lysine; Methionine; Microscopy, Electron; Phenylalanine; Proline; Pronase; Sheep; Structure-Activity Relationship; Threonine; Tyrosine; Wool

1972
[Amino acid metabolism pathology in the convulsive syndrome in young children].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1972, Volume: 72, Issue:10

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Child, Preschool; Cystine; Female; Glutamates; Glutamine; Glycine; Histidine; Humans; Infant; Infant, Newborn; Leucine; Lysine; Male; Methionine; Proline; Seizures; Serine; Tryptophan; Tyrosine; Valine

1972
The adaptation of diastereomeric S-prolyl dipeptide derivatives to the quantitative estimation of R- and S-leucine enantiomers.
    Journal of chromatographic science, 1972, Volume: 10, Issue:3

    Topics: Amino Acid Sequence; Chromatography, Gas; Dipeptides; Esters; Leucine; Methods; Methylation; Proline; Stereoisomerism

1972
Interaction of 4-nitroquinoline 1-oxide and related carcinogens with histone and aliphatic amino acids.
    Gan, 1972, Volume: 63, Issue:6

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Carcinogens; Cattle; Chemical Phenomena; Chemistry; Glutamates; Glycine; Histones; Isoleucine; Leucine; Lysine; Methionine; Proline; Protein Denaturation; Quinolines; Serine; Spectrophotometry; Threonine; Thymus Gland; Valine

1972
Raman spectroscopy.
    Methods in enzymology, 1972, Volume: 26

    Topics: Alanine; Amides; Evaluation Studies as Topic; Glutamates; Glycine; Lasers; Leucine; Mathematics; Methods; Muramidase; Peptides; Proline; Protein Conformation; Spectrophotometry, Ultraviolet; Spectrum Analysis

1972
A new case of hemoglobin Genova 2 2 28(B10) Leu leads to Pro. Further studies on the mechanism of instability and defective synthesis.
    Biochimica et biophysica acta, 1973, Jan-25, Volume: 295, Issue:1

    Topics: Amino Acids; Blood Protein Electrophoresis; Carbon Isotopes; Child; Chromatography, Ion Exchange; Drug Stability; Electrophoresis, Starch Gel; Genetics, Medical; Heme; Hemoglobins; Hemoglobins, Abnormal; Hot Temperature; Humans; Italy; Leucine; Macromolecular Substances; Male; Mutation; Oxygen; Partial Pressure; Peptides; Proline; Reticulocytes

1973
Specific transfer process for intestinal absorption of peptides.
    The Journal of physiology, 1973, Volume: 229, Issue:1

    Topics: Alanine; Animals; Dipeptides; Glycine; Intestinal Absorption; Leucine; Methionine; Proline; Rats

1973
Effect of pentobarbital on amino acid and urea flux in the isolated dog brain.
    The American journal of physiology, 1973, Volume: 224, Issue:3

    Topics: Amino Acids; Anesthesia, General; Animals; Asparagine; Aspartic Acid; Brain; Cerebrovascular Circulation; Dipeptides; Dogs; Glutamates; Glutamine; Glycine; Halothane; Isoleucine; Leucine; Methoxyflurane; Nitrogen; Pentobarbital; Proline; Serine; Taurine; Urea; Valine

1973
Distribution, half-life, and excretion of 14 C- and 3 H-labeled L-prolyl-L-leucyl-glycinamide in the rat.
    Neuroendocrinology, 1973, Volume: 11, Issue:2

    Topics: Adrenal Glands; Amides; Animals; Carbon Isotopes; Glycine; Half-Life; Hypothalamus; Kidney; Leucine; Liver; Melanocyte-Stimulating Hormones; Muscles; Pineal Gland; Pituitary Gland; Plasma Volume; Proline; Rats; Tritium

1973
Basic proteins in neurons containing fibrillary deposits.
    Brain research, 1973, Jan-15, Volume: 49, Issue:1

    Topics: Aluminum; Amino Acids; Animals; Arginine; Brain; Cell Membrane; Centrifugation, Density Gradient; Leucine; Lipid Metabolism; Lysine; Male; Membrane Potentials; Microscopy, Electron; Nerve Tissue Proteins; Neurofibrils; Neurons; Phosphates; Proline; Rabbits; Spinal Cord; Tritium

1973
Inhibition of intestinal amino acid transport by blood sugar lowering biguanides.
    Diabetologia, 1973, Volume: 9, Issue:1

    Topics: Amino Acids; Animals; Biguanides; Biological Transport, Active; Carbon Isotopes; Cricetinae; Glycine; In Vitro Techniques; Intestine, Small; Leucine; Lysine; Methionine; Proline; Time Factors

1973
Isolation of active messenger RNA for s casein from bound polyribosomes of mammary gland.
    Biochemical and biophysical research communications, 1973, Apr-02, Volume: 51, Issue:3

    Topics: Animals; Antibodies; Carbon Isotopes; Caseins; Cell-Free System; Centrifugation, Density Gradient; Electrophoresis, Polyacrylamide Gel; Female; Guinea Pigs; Isoleucine; Leucine; Mammary Glands, Animal; Peptides; Polyribosomes; Proline; Protein Biosynthesis; Reticulocytes; RNA, Messenger; Sheep; Sodium Dodecyl Sulfate; Sucrose; Time Factors; Tritium

1973
The reversal of triparanol-induced cataracts in the rat. 3. Amino acid content and uptake of 14 C -AIB in cataractous and clearing lenses.
    Investigative ophthalmology, 1973, Volume: 12, Issue:5

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Cataract; Cystine; Diet; Glutamates; Glycine; Histidine; Isoleucine; Lens, Crystalline; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rats; Serine; Threonine; Triparanol; Tyrosine; Valine

1973
Synthesis of soluble neuronal proteins in vivo. Age-dependent differences in the incorporation of leucine and phenylalanine.
    Brain research, 1973, May-17, Volume: 54

    Topics: Age Factors; Animals; Carbon Isotopes; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Leucine; Male; Microtubules; Nerve Tissue Proteins; Phenylalanine; Proline; Rats; Tritium; Vinblastine

1973
A cerebello-olivary pathway in the cat: an experimental study using autoradiographic tracing technics.
    Brain research, 1973, Aug-17, Volume: 58, Issue:1

    Topics: Animals; Autoradiography; Cats; Cerebellar Nuclei; Cerebellum; Leucine; Neural Pathways; Olivary Nucleus; Proline; Tritium

1973
Reiteration of DNA complementary to a cytoplasmic non-ribosomal RNA.
    Biochemical and biophysical research communications, 1973, Jul-02, Volume: 53, Issue:1

    Topics: Adenine Nucleotides; Animals; Carrageenan; Collagen; DNA; Granuloma; Guinea Pigs; Kinetics; Leucine; Liver; Nucleic Acid Hybridization; Phosphates; Phosphorus Radioisotopes; Polynucleotides; Proline; Ribonucleases; RNA; Tritium

1973
Sarcosine and imino acid uptake in Saccharomyces chevalieri. Derepression by nitrogen starvation.
    Biochimica et biophysica acta, 1973, Aug-22, Volume: 318, Issue:2

    Topics: Acridines; Aerobiosis; Anaerobiosis; Azetines; Biological Transport; Carbon Radioisotopes; Cycloheximide; Diamines; Fungal Proteins; Hydroxyproline; Imino Acids; Isoleucine; Leucine; Nitrogen; Phenylalanine; Proline; RNA, Messenger; Saccharomyces; Sarcosine; Time Factors; Tritium; Tryptophan

1973
Dopamine synthesis: stimulation by a hypothalamic factor.
    Science (New York, N.Y.), 1973, Nov-23, Volume: 182, Issue:4114

    Topics: Animals; Brain; Corpus Striatum; Dopamine; Glycine; Hypophysectomy; Hypothalamus; Leucine; Male; Melanocyte-Stimulating Hormones; Norepinephrine; Oligopeptides; Peptides; Proline; Rats; Stimulation, Chemical; Tissue Extracts; Tritium; Tyrosine

1973
Deuteron magnetic resonance studies on the microdynamical behavior of partially deuterated oxytocin with neurophysin.
    Journal of molecular biology, 1973, Sep-25, Volume: 79, Issue:3

    Topics: Chromatography, Gel; Chromatography, Thin Layer; Circular Dichroism; Deuterium; Electrophoresis, Polyacrylamide Gel; Glycine; Leucine; Magnetic Resonance Spectroscopy; Mathematics; Neurophysins; Oligopeptides; Oxytocin; Proline; Spectrophotometry, Ultraviolet

1973
The metabolism of amino acids in the bovine lens. Their oxidation as a source of energy.
    The Biochemical journal, 1973, Volume: 136, Issue:1

    Topics: Adenosine Triphosphate; Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Carbon Dioxide; Carbon Radioisotopes; Cattle; Collagen; Energy Metabolism; Glucose; Glutamates; Glutathione; In Vitro Techniques; Lactates; Lens, Crystalline; Leucine; Lipid Metabolism; Lysine; Oxidation-Reduction; Proline; Serine; Taurine; Tryptophan; Tyrosine

1973
Biosynthetic precursors of etamycin, a peptidolactone antibiotic from Streptomyces griseoviridus.
    Canadian journal of biochemistry, 1973, Volume: 51, Issue:12

    Topics: Alanine; Anti-Bacterial Agents; Benzene Derivatives; Carbon Radioisotopes; Glucose; Hydroxyproline; Lactones; Leucine; Lysine; Nitrates; Peptides, Cyclic; Picolinic Acids; Potassium; Proline; Sarcosine; Streptomyces; Structure-Activity Relationship; Threonine; Tritium

1973
Fatty acid inhibition of somatomedin (serum sulfation factor)-stimulated protein and RNA synthesis in embryonic chicken cartilage.
    Biochimica et biophysica acta, 1973, Dec-21, Volume: 331, Issue:3

    Topics: Amino Acids; Animals; Butyrates; Caprylates; Cartilage; Chick Embryo; Chondroitin; Chromatography; Chromatography, Ion Exchange; Collagen; Culture Media; Hydroxyproline; Leucine; Mucoproteins; Polysaccharides; Proline; Protein Biosynthesis; Rats; RNA; Somatomedins; Sulfur Radioisotopes; Sulfuric Acids; Tritium; Tryptophan; Uridine

1973
Tris(hydroxymethyl)aminomethane buffer and amino acid analysis.
    Acta chemica Scandinavica, 1973, Volume: 27, Issue:10

    Topics: Amino Acids; Buffers; Chromatography; Indicators and Reagents; Leucine; Methods; Proline; Spectrophotometry; Tromethamine; Valine

1973
L-prolyl-L-leucyl-glycinamide (PLG): influences on locomotor and stereotyped behavior of cats.
    Brain research, 1973, Dec-07, Volume: 63

    Topics: Animals; Autonomic Nervous System; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Glycine; Humans; Leucine; Locomotion; Melanocyte-Stimulating Hormones; Oligopeptides; Proline; Stereotyped Behavior

1973
[Effect of the set of amino acids contained in casein, extracted soy bean meal, horse beans and wheat gluten on the content of leucine, isoleucine, valine, phenylalanine, tyrosine, glutamic acid, aspartic acid, alanine, glycine and proline in the deprotei
    Archiv fur Tierernahrung, 1973, Volume: 23, Issue:7

    Topics: Alanine; Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Caseins; Chickens; Female; Glutamates; Glutens; Glycine; Glycine max; Isoleucine; Leucine; Phenylalanine; Plant Proteins; Proline; Triticum; Tyrosine; Valine

1973
Regulation of amino acid transport in kidney cortex of newborn rats.
    Science (New York, N.Y.), 1974, Apr-05, Volume: 184, Issue:4132

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Animals, Newborn; Carbon Radioisotopes; Cycloheximide; Cyclopentanes; Dactinomycin; Depression, Chemical; Glycine; In Vitro Techniques; Kidney Cortex; Kinetics; Leucine; Lysine; Methylglycosides; Proline; Rats; Temperature; Valine

1974
Folding of polypeptide chains induced by the amino acid side-chains.
    Journal of molecular biology, 1974, Volume: 83, Issue:3

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Glycine; Leucine; Peptide Chain Elongation, Translational; Peptides; Phenylalanine; Probability; Proline; Protein Conformation; Structure-Activity Relationship

1974
The nature of hypthalamo-neurohypophyseal neurosecretion in the rat. A study by light- and electron microscope autoradiography.
    The Journal of cell biology, 1974, Volume: 60, Issue:3

    Topics: Animals; Autoradiography; Cystine; Ethyl Ethers; Histocytochemistry; Hypothalamus; Isotope Labeling; Leucine; Microscopy, Electron; Neurophysins; Pituitary Gland, Posterior; Proline; Rats; Silver; Subcellular Fractions; Time Factors; Tritium

1974
The specification of the retino-tectal projection in the chick.
    The Journal of comparative neurology, 1974, May-15, Volume: 155, Issue:2

    Topics: Animals; Autoradiography; Brain Mapping; Chick Embryo; Chickens; Leucine; Proline; Retina; Superior Colliculi; Tritium

1974
Thalamic organization of the retino-thalamo-hyperstriatal pathway in the pigeon (Columba livia).
    Experimental brain research, 1974, Feb-28, Volume: 19, Issue:4

    Topics: Animals; Autoradiography; Brain Mapping; Columbidae; Fucose; Leucine; Neural Pathways; Proline; Retina; Telencephalon; Thalamic Nuclei; Tritium

1974
Intracellular free amino acid concentration in human muscle tissue.
    Journal of applied physiology, 1974, Volume: 36, Issue:6

    Topics: Adult; Alanine; Amino Acids; Arginine; Asparagine; Biopsy, Needle; Body Water; Chlorides; Citrulline; Extracellular Space; Female; Glutamates; Glutamine; Glycine; Histidine; Humans; Isoleucine; Leucine; Lipid Metabolism; Male; Muscles; Ornithine; Phenylalanine; Proline; Serine; Taurine; Tyrosine; Valine

1974
Quantitative evaluation of nonspecific nitrogen sources for the growing chick.
    Poultry science, 1974, Volume: 53, Issue:1

    Topics: Amino Acids, Essential; Animals; Arginine; Body Composition; Body Water; Body Weight; Chickens; Citrates; Glutamates; Glycine; Isoleucine; Leucine; Lysine; Male; Nitrogen; Proline; Quaternary Ammonium Compounds; Urea; Valine

1974
Changes in the concentration of free amino acids in the haemolymph of Rhodnius prolixus during the fifth instar.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1974, Jun-15, Volume: 48, Issue:2

    Topics: Amino Acids; Animals; Hemolymph; Histidine; Insecta; Leucine; Metamorphosis, Biological; Phenylalanine; Proline; Time Factors; Tyrosine

1974
Oxotremorine antagonism by prolyl-leucyl-glycine-amide administered by different routes and with several anticholinergics.
    Pharmacology, biochemistry, and behavior, 1974, Volume: 2, Issue:3

    Topics: Administration, Oral; Amides; Analysis of Variance; Animals; Behavior, Animal; Benztropine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Glycine; Injections, Intravenous; Injections, Subcutaneous; Leucine; Male; Mice; Mice, Inbred ICR; Oligopeptides; Oxotremorine; Parasympatholytics; Proline; Scopolamine; Time Factors; Trihexyphenidyl

1974
Transport of L-methionine in rat intestine and kidney.
    Pediatric research, 1974, Volume: 8, Issue:6

    Topics: Anaerobiosis; Animals; Biological Transport, Active; Carbon Radioisotopes; Chromatography; Culture Media; Depression, Chemical; Ethionine; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Mucosa; Intestines; Kidney Cortex; Leucine; Lysine; Male; Methionine; Proline; Sodium; Sucrose; Tryptophan; Valine

1974
Cell-free protein synthesis by rat brain in triethyl tin intoxication.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:1

    Topics: Animals; Brain Edema; Carbon Radioisotopes; Cerebral Cortex; Corpus Callosum; Depression, Chemical; Female; Injections, Intraperitoneal; Leucine; Male; Proline; Subcellular Fractions; Time Factors; Tin

1974
[Multiplicity of transport systems in the luminal membrane of the nephron in the normal rat].
    Revue canadienne de biologie, 1974, Volume: 33, Issue:2

    Topics: Alanine; Animals; Biological Transport; Carbon Radioisotopes; Female; Glycine; Hydroxyproline; Imino Acids; Inulin; Kidney; Leucine; Membranes; Nephrons; Phenylalanine; Proline; Rats

1974
[Synthesis of radioactive potential precursers of peptide moieties of ergotoxine alkaloids].
    Die Pharmazie, 1974, Volume: 29, Issue:3

    Topics: Alanine; Carbon Radioisotopes; Cyclization; Ergolines; Ergot Alkaloids; Esters; Glycine; Isotope Labeling; Lactams; Leucine; Methods; Peptides; Proline; Valine

1974
In vitro synthesis of collagen peptides on fetal and neonatal rat skin polysomes by rabbit reticulocyte initiation factors.
    Archives of biochemistry and biophysics, 1974, Volume: 163, Issue:1

    Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Collagen; Female; Fetus; Leucine; Peptide Biosynthesis; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Polyribosomes; Pregnancy; Proline; Protein Biosynthesis; Rabbits; Rats; Reticulocytes; Skin; Spectrophotometry, Ultraviolet; Time Factors; Tritium

1974
The mean geometry of the peptide unit from crystal structure data.
    Biochimica et biophysica acta, 1974, Aug-08, Volume: 359, Issue:2

    Topics: Acetamides; Alanine; Crystallography; Glutathione; Glycine; Leucine; Models, Structural; Molecular Conformation; Oligopeptides; Phenylalanine; Proline; Protein Conformation; Tyrosine; X-Ray Diffraction

1974
DOPA potentiation in ablated animals and brain levels of biogenic amines in intact animals after prolyl-leucylglycinamide.
    Neuroendocrinology, 1974, Volume: 14, Issue:5

    Topics: Administration, Oral; Adrenal Glands; Amides; Animals; Behavior, Animal; Biogenic Amines; Brain; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Female; Glycine; Homovanillic Acid; Kidney; Leucine; Male; Mice; Norepinephrine; Ovary; Parathyroid Glands; Pargyline; Peptides; Proline; Rats; Serotonin; Spleen; Stimulation, Chemical; Testis; Thymus Gland

1974
Studies on the synthesis of amino acids by Mycobacteria. I. Incorporation of 14C carbon in the form of acetate into amino acids of tubercle bacilli.
    Archivum immunologiae et therapiae experimentalis, 1967, Volume: 15, Issue:2

    Topics: Acetates; Amino Acids; Arginine; Aspartic Acid; Autoradiography; Carbon Isotopes; Chromatography; Densitometry; Glutamates; Isoleucine; Leucine; Mycobacterium bovis; Proline

1967
Mode of action of enomycin, an antitumor antibiotic of high molecular weight. I. Inhibition of protein synthesis.
    Journal of biochemistry, 1967, Volume: 61, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Escherichia coli; HeLa Cells; In Vitro Techniques; Leucine; Liver; Lysine; Magnesium; Mice; Phenylalanine; Polynucleotides; Proline; Protein Biosynthesis; Rats; RNA, Messenger; RNA, Transfer; Thymidine; Time Factors; Uridine

1967
Formation of filaments and synthesis of macromolecules at temperatures below the minimum for growth of Escherichia coli.
    Journal of bacteriology, 1968, Volume: 95, Issue:1

    Topics: Bacterial Proteins; Carbon Isotopes; Cell Division; DNA, Bacterial; Escherichia coli; Leucine; Microscopy, Electron; Microscopy, Phase-Contrast; Pimelic Acids; Proline; RNA, Bacterial; Temperature; Thymine; Tritium; Uracil

1968
Bovine pepsinogen and pepsin. I. Isolation, purification, and some properties of the pepsinogen.
    The Journal of biological chemistry, 1968, Apr-25, Volume: 243, Issue:8

    Topics: Abomasum; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Electrophoresis, Disc; Enzyme Precursors; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Molecular Weight; Pepsin A; Proline; Swine; Tryptophan; Ultracentrifugation

1968
Mechanism of action of bottromycin in polypeptide biosynthesis.
    Journal of biochemistry, 1968, Volume: 63, Issue:1

    Topics: Anti-Bacterial Agents; Carbon Isotopes; Cell-Free System; Centrifugation, Density Gradient; Chloramphenicol; Dialysis; Escherichia coli; Leucine; Peptides; Phenylalanine; Proline; Protein Binding; Puromycin; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Serine; Valine

1968
An application of diagonal electrophoresis to the selective purification of serine phosphate peptides. Serine phosphate peptides from ovalbumin.
    The Biochemical journal, 1968, Volume: 110, Issue:1

    Topics: Alkaline Phosphatase; Amino Acid Sequence; Chymotrypsin; Electrophoresis; Isoleucine; Leucine; Lysine; Ovalbumin; Pepsin A; Peptides; Proline; Serine; Trypsin

1968
The amino acid sequences of some tryptic peptides from porcine pepsinogen.
    The Journal of biological chemistry, 1968, Dec-10, Volume: 243, Issue:23

    Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Asparagine; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Enzyme Precursors; Glycine; Histidine; Leucine; Lysine; Pepsin A; Peptides; Proline; Swine; Trypsin; Valine

1968
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
    The Journal of vitaminology, 1968, Sep-10, Volume: 14, Issue:3

    Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine

1968
[Study of the inactivation of the acceptor properties of transfer ribonucleic acids by ionizing radiation].
    Bulletin de la Societe de chimie biologique, 1968, Volume: 50, Issue:11

    Topics: Alkaline Phosphatase; Amino Acids; Carbon Isotopes; Chromatography; Cobalt Isotopes; Escherichia coli; Esters; Isoleucine; Leucine; Phenylalanine; Phosphates; Proline; Radiation Effects; RNA, Transfer; Saccharomyces; Serine; Solutions; Spectrophotometry; Water

1968
Aminoacyl transfer ribonucleic acid synthetases from cell-free extract of Plasmodium berghei.
    Science (New York, N.Y.), 1969, May-02, Volume: 164, Issue:3879

    Topics: Acridines; Amino Acids; Carbon Isotopes; Cell-Free System; Escherichia coli; Genetic Code; Histidine; Leucine; Ligases; Liver; Lysine; Plasmodium; Proline; Pyrimethamine; Quinacrine; RNA, Transfer; Species Specificity; Stilbamidines; Threonine; Tyrosine; Valine

1969
Arginine transport and metabolism in osmotically shocked and unshocked cells of Escherichia coli W.
    The Journal of biological chemistry, 1969, May-25, Volume: 244, Issue:10

    Topics: Acetates; Arginine; Biological Transport; Canavanine; Carbon Isotopes; Carboxy-Lyases; Citrulline; Cold Temperature; Escherichia coli; Glutamates; Guanidines; Hydrochloric Acid; Leucine; Lysine; Ornithine; Osmolar Concentration; Proline; Tromethamine; Urea

1969
Amino acid antagonist death in Escherichia coli.
    Journal of bacteriology, 1969, Volume: 99, Issue:1

    Topics: Amino Acids; Escherichia coli; Leucine; Microscopy, Electron; Proline; Threonine; Tryptophan

1969
A simple procedure for fractionation of transfer RNA.
    Analytical biochemistry, 1970, Volume: 33, Issue:1

    Topics: Albumins; Cellulose; Chromatography; Escherichia coli; Filtration; Histidine; Leucine; Lysine; Membranes, Artificial; Methionine; Methods; Phenylalanine; Proline; RNA, Bacterial; RNA, Transfer; Time Factors; Tritium; Tyrosine

1970
[Use of the replication method for obtaining bacteria of the E. coli group resistant and sensitive to antibiotics].
    Antibiotiki, 1970, Volume: 15, Issue:3

    Topics: Animals; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections; Genetics, Microbial; Leucine; Mice; Microbial Sensitivity Tests; Mutation; Proline; Recombination, Genetic; Shigella dysenteriae; Shigella sonnei; Streptomycin; Threonine

1970
Substrate specificity of ribosomal peptidyl transferase. The effect of the nature of the amino acid side chain on the acceptor activity of 2'(3')-O-aminoacyladenosines.
    European journal of biochemistry, 1970, Volume: 16, Issue:1

    Topics: Acetates; Acyltransferases; Alanine; Amino Acids; Binding Sites; Carbon Isotopes; Escherichia coli; Glutamine; Glycine; Imidazoles; Leucine; Lysine; Methionine; Nucleosides; Peptides; Phenylalanine; Proline; Ribosomes; RNA, Transfer; Serine; Stereoisomerism; Valine

1970
Messenger and template activities of chemically modified polynucleotides.
    Biochemistry, 1970, Sep-15, Volume: 9, Issue:19

    Topics: Adenosine Triphosphate; Alkylating Agents; Carbon Isotopes; Cell-Free System; Cytosine Nucleotides; Escherichia coli; Guanidines; Guanine Nucleotides; Hydroxylamines; Leucine; Mutation; Nitrites; Nitroso Compounds; Phenylalanine; Polynucleotides; Proline; Radiation Effects; RNA Nucleotidyltransferases; RNA, Transfer; Serine; Templates, Genetic; Ultraviolet Rays; Uracil Nucleotides

1970
Differential recovery of auxotrophs after penicillin enrichment in Escherichia coli.
    Journal of bacteriology, 1971, Volume: 106, Issue:2

    Topics: Bacteriological Techniques; Culture Media; Escherichia coli; Genes; Genetics, Microbial; Hypertonic Solutions; Hypotonic Solutions; Leucine; Methionine; Mutation; Penicillin G; Proline

1971
Incorporation of high molecular weight polynucleotides by isolated mitochondria.
    Nature, 1971, May-07, Volume: 231, Issue:5297

    Topics: Animals; Anura; Centrifugation, Density Gradient; Female; In Vitro Techniques; Leucine; Lysine; Methionine; Mitochondria; Molecular Weight; Ovary; Peptide Biosynthesis; Phenylalanine; Polynucleotides; Proline; Ribosomes; Stimulation, Chemical; Templates, Genetic; Tritium; Uracil Nucleotides

1971
Synthesis and breakdown of proteins in Escherichia coli during amino-acid starvation.
    Journal of molecular biology, 1971, Apr-14, Volume: 57, Issue:1

    Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chromatography, Gel; Escherichia coli; Galactosidases; Genetic Code; Leucine; Methionine; Molecular Weight; Peptides; Proline; Ribosomes; RNA, Messenger; Tritium

1971
2'-O-Methyl polynucleotides as templates for cell-free amino acid incorporation.
    Biochemistry, 1971, Jun-22, Volume: 10, Issue:13

    Topics: Adenine Nucleotides; Amino Acids; Carbon Isotopes; Cell-Free System; Centrifugation, Density Gradient; Cytosine Nucleotides; Escherichia coli; Ethers; Genetic Code; Isoleucine; Kinetics; Leucine; Methanol; Methylation; Molecular Biology; Neomycin; Phenylalanine; Polynucleotides; Proline; Protein Biosynthesis; Ribonucleotides; RNA, Bacterial; Serine; Templates, Genetic; Tyrosine; Uracil Nucleotides

1971
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.
    Biochemical and biophysical research communications, 1971, Jun-18, Volume: 43, Issue:6

    Topics: Acetates; Amino Acid Sequence; Amino Acids; Anhydrides; Animals; Arginine; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Follicle Stimulating Hormone; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Hypothalamus; Leucine; Luteinizing Hormone; Mass Spectrometry; Methods; Naphthalenes; Peptides; Pituitary Hormone-Releasing Hormones; Proline; Serine; Sulfonic Acids; Swine; Thiocyanates; Tritium; Tryptophan; Tyrosine

1971
Thiobacillus denitrificans as an obligate chemolithotroph. Isolation and growth studies.
    Archiv fur Mikrobiologie, 1971, Volume: 78, Issue:3

    Topics: Acetates; Anaerobiosis; Arginine; Bacteriological Techniques; Carbon; Carbon Isotopes; Culture Media; Glucose; Glutamates; Glycerides; Lactates; Leucine; Lipids; Manometry; Proline; Proteins; Pyruvates; Succinates; Thiobacillus; Thiosulfates

1971
Methionineless death in Escherichia coli.
    Journal of bacteriology, 1971, Volume: 108, Issue:3

    Topics: Amino Acyl-tRNA Synthetases; Arginine; Bacterial Proteins; Bacteriological Techniques; Carbon Isotopes; Cell Survival; Culture Media; Decarboxylation; DNA, Bacterial; Escherichia coli; Filtration; Isoleucine; Leucine; Methionine; Proline; Spermidine; Spermine; Thymine; Tryptophan; Uracil

1971
Uptake of amino acids by actidione-treated yeast cells. I. Specificity of carriers.
    Folia microbiologica, 1971, Volume: 16, Issue:6

    Topics: Amino Acids; Arginine; Aspartic Acid; Binding Sites; Biological Transport; Carrier Proteins; Cell Membrane; Cycloheximide; Cysteine; Glutamates; Glycine; Histidine; Kinetics; Leucine; Lysine; Methionine; Proline; Protein Biosynthesis; Saccharomyces; Saccharomyces cerevisiae

1971
The comparative biochemistry of the organic matrix proteins of developing enamel. I. Amino acid composition.
    Archives of oral biology, 1967, Volume: 12, Issue:3

    Topics: Amelogenesis; Amino Acids; Animals; Artiodactyla; Bicuspid; Cattle; Dental Enamel Proteins; Dogs; Female; Glutamates; Goats; Haplorhini; Histidine; Humans; In Vitro Techniques; Incisor; Leucine; Pregnancy; Pregnancy, Animal; Proline; Protein Binding; Sheep; Swine

1967
Species specificity of sRNA's and aminoacyl-sRNA synthetases in some aerobic bacteria.
    Biochimica et biophysica acta, 1966, Aug-17, Volume: 123, Issue:2

    Topics: Alcaligenes; Amino Acids; Chromatography, Paper; Escherichia coli; Leucine; Ligases; Proline; Pseudomonas; Pseudomonas aeruginosa; RNA, Bacterial; RNA, Transfer; Saccharomyces; Valine

1966
Species differences of serum amino acid beta-napthylamidases.
    Enzymologia, 1968, Feb-29, Volume: 34, Issue:2

    Topics: Alanine; Amides; Amino Acids; Aminopeptidases; Animals; Arginine; Chickens; Cyprinidae; Dipeptides; Dogs; Female; Glutamine; Glycine; Haplorhini; Humans; Isoleucine; Leucine; Lysine; Methionine; Mice; Naphthalenes; Phenylalanine; Proline; Rats; Serine; Species Specificity; Valine

1968
Studies on the synthesis of amino acids by mycobacteria. II. Influence of amino acid content of the medium on the synthesis of amino acids of 14 c labeled tubercle bacilli.
    Archivum immunologiae et therapiae experimentalis, 1967, Volume: 15, Issue:5

    Topics: Acetates; Amino Acids; Autoradiography; Carbon Isotopes; Caseins; Chromatography, Paper; Culture Media; Densitometry; Isoleucine; Leucine; Mycobacterium tuberculosis; Proline

1967
"Dysgonic" strains of mycobacterium tuberculosis on Ogawa's egg medium isolated as pathogens from patients suffering from lung tuberculosis. II. Growth-inhibitory effects of D-asparagine, D-aspartic acid, Dl-serine, or L-serine against "dysgonic".
    The Japanese journal of tuberculosis, 1967, Volume: 14, Issue:3

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Culture Media; Depression, Chemical; Glutamine; Histidine; Humans; Leucine; Mycobacterium tuberculosis; Proline; Serine; Tuberculosis, Pulmonary; Valine

1967
Catabolite repression and feedback inhibition of protease in Streptococcus faecalis var. liquefaciens.
    Canadian journal of microbiology, 1968, Volume: 14, Issue:12

    Topics: Amino Acids; Dipeptides; Enterococcus faecalis; Enzyme Repression; Feedback; Galactosidases; Isoleucine; Leucine; Peptide Hydrolases; Peptides; Phenylalanine; Proline; Tryptophan; Valine

1968
o-Quinones formed in plant extracts. Their reactions with amino acids and peptides.
    The Biochemical journal, 1969, Volume: 112, Issue:5

    Topics: Amino Acids; Catechol Oxidase; Chemical Phenomena; Chemistry; Chlorogenic Acid; Cinnamates; Color; Cysteine; Glycine; Histidine; Hydrogen-Ion Concentration; Leucine; Lysine; Manometry; Nicotiana; Oxygen Consumption; Peptides; Plant Extracts; Plants; Plants, Toxic; Proline; Quinones; Spectrophotometry; Time Factors; Tryptophan

1969
Influence of carbon or nitrogen starvation on amino acid transport in Pseudomonas aeruginosa.
    Journal of bacteriology, 1969, Volume: 100, Issue:1

    Topics: Alanine; Amino Acids; Biological Transport; Carbon; Carbon Isotopes; Chloramphenicol; Glutamates; Glycine; Histidine; Leucine; Nitrogen; Proline; Pseudomonas aeruginosa; Valine

1969
Plasma amino acid levels in diabetic ketoacidosis.
    Diabetes, 1970, Volume: 19, Issue:10

    Topics: Adolescent; Adult; Aged; Alanine; Amino Acids; Arginine; Butyrates; Child; Citrulline; Cystine; Diabetic Ketoacidosis; Female; Glycine; Histidine; Humans; Insulin; Isoleucine; Leucine; Lysine; Male; Methionine; Middle Aged; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1970
Studies on the induction and repression of enzymes in rat liver. VI. Some properties and the metabolic regulation of two isozymic forms of serine dehydratase.
    The Journal of biological chemistry, 1971, Apr-25, Volume: 246, Issue:8

    Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Chromatography, DEAE-Cellulose; Cortisone; Crystallization; Diabetes Mellitus, Experimental; Electrophoresis, Disc; Enzyme Induction; Glucagon; Hydro-Lyases; Immune Sera; Immunodiffusion; Isoenzymes; L-Serine Dehydratase; Leucine; Liver; Lysine; Male; Molecular Weight; Phosphates; Proline; Pyridoxal Phosphate; Rats; Spectrophotometry; Tritium; Ultraviolet Rays

1971
Synthesis of analogs of the thyrotropin-releasing hormone and structure-activity relationship.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:6

    Topics: Alanine; Amides; Animals; Benzyl Compounds; Biological Assay; Esters; Histidine; Leucine; Magnetic Resonance Spectroscopy; Mice; Peptides; Proline; Pyrrolidinones; Thyrotropin; Thyrotropin-Releasing Hormone; Valine

1971
Crystal structure and conformation of the cyclic dipeptide cyclo-L-prolyl-L-leucyl.
    Journal of the American Chemical Society, 1972, Jan-12, Volume: 94, Issue:1

    Topics: Amino Acid Sequence; Crystallography; Dipeptides; Leucine; Peptides, Cyclic; Proline; Protein Conformation; Structure-Activity Relationship

1972
Brain peptidases: conversion and inactivation of kinin hormones.
    Journal of neurochemistry, 1972, Volume: 19, Issue:1

    Topics: Amino Acids; Animals; Arginine; Brain; Electrophoresis; Guinea Pigs; Ileum; Kinins; Leucine; Lysine; Methionine; Peptide Hydrolases; Proline; Rabbits

1972
[On the incorporation of dipeptides in ergotoxin alcaloids].
    Experientia, 1972, Feb-15, Volume: 28, Issue:2

    Topics: Culture Techniques; Dipeptides; Ergot Alkaloids; Leucine; Proline; Toxins, Biological

1972
Sow colostral free amino acids and their importance for the newborn piglet.
    Acta veterinaria Scandinavica, 1972, Volume: 13, Issue:1

    Topics: Amino Acids; Animals; Animals, Newborn; Colostrum; Female; Leucine; Pregnancy; Proline; Swine; Time Factors

1972
Characteristics of amino acid accumulation by synaptosomal particles isolated from rat brain.
    Journal of neurochemistry, 1972, Volume: 19, Issue:6

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Brain; Carbon Isotopes; Leucine; Lysine; Nerve Endings; Ouabain; Potassium; Proline; Rats; Serine; Sodium; Stimulation, Chemical; Synaptic Vesicles; Synaptosomes; Threonine; Tyrosine; Valine

1972
Regulation of amino acid transport in chick embryo heart cells. I. Adaptive system of mediation for neutral amino acids.
    Biochimica et biophysica acta, 1972, May-09, Volume: 266, Issue:2

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Cells; Chick Embryo; Cycloheximide; Cyclopentanes; Dactinomycin; Glycine; Heart; Kinetics; Leucine; Myocardium; Phenylalanine; Proline; Puromycin; Time Factors

1972
Effects of phenothiazines on amino acid transport and protein synthesis in isolated nerve endings.
    Biochemical pharmacology, 1972, May-01, Volume: 21, Issue:9

    Topics: Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chlorpromazine; Kinetics; Leucine; Nerve Endings; Phenothiazines; Phenylalanine; Proline; Promazine; Protein Biosynthesis; Rats; Synaptosomes

1972
Amino acid transport by rat small intestine. Galactose inhibition of transepithelial net transport as a result of stimulation of bidirectional efflux from the epithelium.
    Biochimica et biophysica acta, 1972, Jun-20, Volume: 266, Issue:3

    Topics: Animals; Biological Transport; Carbon Isotopes; Cell Membrane; Epithelial Cells; Epithelium; Galactose; Ileum; Ilium; Jejunum; Kinetics; Leucine; Male; Proline; Rats; Time Factors

1972
A basis for the difference in the inhibition of the uptake of various neutral amino acids by lysine in intestinal epithelial cells.
    Biochimica et biophysica acta, 1972, Apr-14, Volume: 266, Issue:1

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Epithelial Cells; Epithelium; Histidine; Intestinal Mucosa; Intestines; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Rats; Sodium; Threonine; Tryptophan; Valine

1972
[Phenotypic and genetic analysis of the "nutrient markers" of Staphylococcus aureus and their taxonomic significance].
    Zeitschrift fur allgemeine Mikrobiologie, 1972, Volume: 12, Issue:1

    Topics: Animals; Arginine; Cattle; Cysteine; Dogs; Genetics, Microbial; Genotype; Humans; Leucine; Methionine; Nicotinic Acids; Phenotype; Proline; Rabbits; Staphylococcus; Swine; Thiamine; Threonine; Transduction, Genetic; Valine

1972
[Concentration changes of free amino acids in blood plasma of patients under radiotherapy. (With reference to statistical results)].
    Strahlentherapie, 1972, Volume: 143, Issue:4

    Topics: Alanine; Amino Acids; Bronchial Neoplasms; Carcinoma; Cobalt Isotopes; Dysgerminoma; Esophageal Neoplasms; Female; Genital Neoplasms, Female; Hodgkin Disease; Humans; Leucine; Male; Neoplasms; Phenylalanine; Proline; Radiation Injuries; Sex Factors; Statistics as Topic; Tyrosine; Urinary Bladder Neoplasms; Valine

1972
Amino acid patterns in the blood plasma of the young bovine.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1972, Volume: 42, Issue:2

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Cystine; Female; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1972
Purification and properties of glycylprolyl -naphthylamidase in human submaxillary gland.
    Biochimica et biophysica acta, 1972, Feb-28, Volume: 258, Issue:2

    Topics: Amidohydrolases; Ammonium Sulfate; Animals; Autolysis; Cattle; Cell Nucleus; Chromatography, Gel; Electrophoresis, Disc; Glycine; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Microsomes; Mitochondria; Molecular Weight; Naphthalenes; Proline; Solubility; Species Specificity; Structure-Activity Relationship; Submandibular Gland

1972
Axonal transport in embryonic visual system in zebrafish.
    Experimental brain research, 1972, Volume: 15, Issue:2

    Topics: Animals; Autoradiography; Axons; Cyprinidae; Inferior Colliculi; Leucine; Nerve Tissue Proteins; Proline; Superior Colliculi; Tritium; Visual Cortex; Visual Pathways

1972
Transfer RNA changes in rat granulation tissue possibly related to collagen synthesis.
    Biochemical and biophysical research communications, 1972, Oct-06, Volume: 49, Issue:1

    Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Cellulose; Chromatography, DEAE-Cellulose; Collagen; Glycine; Granulation Tissue; Leucine; Lysine; Male; Proline; Rats; RNA, Transfer; Serine; Time Factors; Tritium

1972
Transport of amino acids into the oestrogen-primed uterus. Enchancement of the uptake by a preliminary incubation.
    The Biochemical journal, 1972, Volume: 128, Issue:1

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Dinitrophenols; Estradiol; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Leucine; Phenylalanine; Potassium; Proline; Rats; Sodium; Time Factors; Uterus; Valine

1972
Haemoglobin Denmark Hill 95 (G2) Pro-Ala, a variant with unusual electrophoretic and oxygen-binding properties.
    Biochimica et biophysica acta, 1972, Oct-31, Volume: 278, Issue:3

    Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Electrophoresis, Paper; Electrophoresis, Starch Gel; Female; Gestational Age; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Leucine; London; Molecular Biology; Mutation; Oxygen; Peptides; Pregnancy; Proline; Protein Binding; Serine

1972
Effect of excess levels of individual amino acids on growth of rats fed casein diets.
    The Journal of nutrition, 1971, Volume: 101, Issue:9

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Caseins; Cystine; Depression, Chemical; Dietary Proteins; DNA; Glutamates; Glycine; Growth; Histidine; Isoleucine; Leucine; Liver; Lysine; Male; Methionine; Organ Size; Phenylalanine; Proline; Proteins; Rats; RNA; Serine; Stereoisomerism; Stimulation, Chemical; Threonine; Tryptophan; Tyrosine; Valine

1971
Effect of dietary protein level on plasma free amino acids in the chicken.
    The Journal of nutrition, 1971, Volume: 101, Issue:9

    Topics: Alanine; Amino Acids; Animals; Blood; Body Weight; Caseins; Chickens; Depression, Chemical; Dietary Proteins; Glycine; Isoleucine; Leucine; Lysine; Male; Methionine; Proline; Proteins; Serine; Stimulation, Chemical; Threonine; Tyrosine; Valine

1971
Quantitative changes in plasma amino acids induced by oral contraceptives.
    Clinical science, 1971, Volume: 41, Issue:4

    Topics: Adult; Alanine; Amino Acids; Contraceptives, Oral; Female; Glutamine; Glycine; Gonadal Steroid Hormones; Humans; Isoleucine; Leucine; Ornithine; Ovulation; Proline; Serine; Tyrosine; Valine

1971
Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy. Preliminary report.
    American journal of obstetrics and gynecology, 1971, Sep-15, Volume: 111, Issue:2

    Topics: Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Arginine; Aspartic Acid; Citrulline; Cystine; Female; Gestational Age; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Proline; Serine; Threonine; Tyrosine; Valine

1971
Incorporation in vitro of ( 14 C)leucine into the mitochondrial protein of Lucilia cuprina. 2. Energy requirements.
    European journal of biochemistry, 1971, Sep-13, Volume: 22, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diptera; Germ-Free Life; In Vitro Techniques; Isoleucine; Leucine; Mitochondria, Muscle; Oligomycins; Oxygen Consumption; Proline; Protein Biosynthesis; Valine

1971
Amino acid immobilization of fungal motile cells.
    Archiv fur Mikrobiologie, 1971, Volume: 78, Issue:1

    Topics: Amino Acids; Cell Count; Culture Media; Drug Synergism; Eukaryota; Fungi; Immobilization; Isomerism; Leucine; Lysine; Proline; Spores; Time Factors

1971
Studies on the conformation of amino acids. VI. Conformation of the proline ring as observed in crystal structures of amino acids and peptides.
    International journal of protein research, 1971, Volume: 3, Issue:1

    Topics: Amino Acids; Benzyl Compounds; Bromine; Chemical Phenomena; Chemistry, Physical; Copper; Crystallography; Cyclopentanes; Dipeptides; Formates; Glycine; Hydroxyproline; Leucine; Models, Structural; Peptides; Phenylalanine; Proline; Sulfonic Acids; Toluene

1971
Acidic and basic amino acid transport systems of Penicillium chrysogenum.
    Archives of biochemistry and biophysics, 1971, Volume: 144, Issue:1

    Topics: Adipates; Aminobutyrates; Arginine; Aspartic Acid; Biological Transport; Carbon Isotopes; Chromatography, Paper; Cycloheximide; Feedback; Glutamates; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Membrane Transport Proteins; Methionine; Ornithine; Osmolar Concentration; Penicillium; Phenylalanine; Proline; Sodium Chloride; Temperature

1971
The effect of dietary fluoride on plasma free amino acid concentrations in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 138, Issue:2

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Diet; Feeding Behavior; Female; Fluorides; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rats; Rats, Inbred Strains; Serine; Threonine; Tryptophan; Tyrosine; Valine

1971
Quantitative determination of intestinal peptide hydrolase activity using L-amino acid oxidase.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 33, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Celiac Disease; Child; Diarrhea; Dipeptides; Glycoside Hydrolases; Guinea Pigs; Humans; Intestinal Mucosa; Intestines; Isoleucine; Kinetics; Lactose; Leucine; Mathematics; Methionine; Peptide Hydrolases; Peroxidases; Phenylalanine; Proline; Spectrophotometry

1971
Stimulation of basic amino acid uptake by certain neutral amino acids in isolated intestinal epithelial cells.
    Biochimica et biophysica acta, 1971, Jul-06, Volume: 241, Issue:1

    Topics: Alanine; Animals; Arginine; Biological Transport; Biological Transport, Active; Carbon Isotopes; Depression, Chemical; Epithelial Cells; Epithelium; Glycine; Histidine; Hydrochloric Acid; Intestinal Mucosa; Intestines; Inulin; Isoleucine; Kinetics; Leucine; Lysine; Male; Mathematics; Methionine; Ornithine; Phenylalanine; Proline; Rats; Rats, Inbred Strains; Serous Membrane; Sodium; Stimulation, Chemical; Tritium; Tryptophan; Valine

1971
Microdegradation procedure for radioactive peptide ergot alkaloids.
    Journal of pharmaceutical sciences, 1971, Volume: 60, Issue:6

    Topics: Amino Acids; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Dinitrophenols; Ergolines; Ergot Alkaloids; Hydrolysis; Keto Acids; Leucine; Peptides; Proline; Pyruvates; Valine

1971
Application of gas-liquid radiochromatography to determination of the optical purity of carbon-14 labeled amino acids.
    Analytical biochemistry, 1971, Volume: 44, Issue:2

    Topics: Alanine; Amino Acids; Carbon Isotopes; Chlorella; Chromatography, Gas; Cold Temperature; Drug Stability; Leucine; Methods; Proline; Serine; Stereoisomerism; Time Factors; Valine

1971
[Antineoplastic effect and chemical structure of protamines of various origin].
    Antibiotiki, 1971, Volume: 16, Issue:9

    Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Carcinoma, Ehrlich Tumor; Depression, Chemical; Fishes; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Leucine; Leukemia, Experimental; Lysine; Methionine; Mice; Proline; Protamines; Sarcoma 37; Serine; Threonine

1971
Studies of intestinal transport defect in Hartnup disease.
    Gastroenterology, 1971, Volume: 61, Issue:4

    Topics: Adolescent; Biological Transport; Carbon Isotopes; Child; Culture Techniques; Feces; Genes, Recessive; Hartnup Disease; Humans; Intellectual Disability; Intestinal Mucosa; Jejunum; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Tryptophan

1971
Transport interaction of sugars and amino acids in mammalian kidney.
    Biochimica et biophysica acta, 1971, Sep-14, Volume: 241, Issue:3

    Topics: Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Depression, Chemical; Extracellular Space; Glycine; Glycosides; Histidine; In Vitro Techniques; Inulin; Kidney; Kinetics; Leucine; Lysine; Mathematics; Methionine; Proline; Rats; Tryptophan; Valine

1971
Biosynthesis of peptide-type ergot alkaloids. Ergocornine and ergocryptine.
    Lloydia, 1971, Volume: 34, Issue:4

    Topics: Claviceps; Ergot Alkaloids; Hydroxy Acids; Leucine; Lysergic Acid; Proline; Pyruvates; Stereoisomerism; Valine

1971
Comparison of invariant residues in the variable and constant regions of human K, human L, and mouse K Bence-Jones proteins.
    Proceedings of the National Academy of Sciences of the United States of America, 1967, Volume: 58, Issue:1

    Topics: Amino Acid Sequence; Animals; Bence Jones Protein; Cysteine; Glutamates; Histidine; Humans; In Vitro Techniques; Leucine; Lysine; Mice; Phenylalanine; Proline; Serine; Tryptophan; Valine

1967
The influence of short-range interactions on protein conformation. I. Side chain-backbone interactions within a single peptide unit.
    Proceedings of the National Academy of Sciences of the United States of America, 1968, Volume: 61, Issue:4

    Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Binding Sites; Cystine; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Kinetics; Leucine; Lysine; Methionine; Muramidase; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1968
Membranes of animal cells. 3. Amino acid incorporation by isolated surface membranes.
    Proceedings of the National Academy of Sciences of the United States of America, 1969, Volume: 63, Issue:2

    Topics: Amino Acids; Animals; Carbon Isotopes; Cell Membrane; Electrophoresis; Fibroblasts; L Cells; Leucine; Mice; Microsomes; Proline; RNA; Surface Properties; Tyrosine

1969
Isoaccepting transfer RNA's of L-M cells in culture and after tumor induction in C3H mice.
    Proceedings of the National Academy of Sciences of the United States of America, 1969, Volume: 64, Issue:4

    Topics: Alanine; Animals; Arginine; Aspartic Acid; Cell Line; Chromatography; Connective Tissue; Culture Media; Culture Techniques; Female; Fibrosarcoma; Glycine; Histidine; Isoleucine; Leucine; Ligases; Lysine; Male; Methionine; Mice; Phenylalanine; Proline; RNA, Transfer; Serine; Threonine; Tryptophan; Tyrosine; Valine

1969
Transfer RNA species in normal and leukemic human lymphoblasts.
    Journal of molecular biology, 1970, Sep-14, Volume: 52, Issue:2

    Topics: Amino Acids; Carbon Isotopes; Cell Line; Chromatography; Glutamine; Glycine; Humans; Leucine; Leukemia, Lymphoid; Ligases; Lymphocytes; Proline; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine

1970
A comparative study of x-ray diffraction and infrared absorption properties and amino-acid analysis of bovine enamel.
    Archives of oral biology, 1971, Volume: 16, Issue:7

    Topics: Amino Acids; Ammonia; Animals; Apatites; Arginine; Cattle; Crystallization; Dental Enamel; Glutamates; Glycine; Hydroxyproline; Infrared Rays; Leucine; Lysine; Odontogenesis; Proline; Spectrum Analysis; X-Ray Diffraction

1971
Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone.
    Proceedings of the National Academy of Sciences of the United States of America, 1971, Volume: 68, Issue:7

    Topics: Animals; Endopeptidases; Estrus; Female; Glycine; Hypothalamus; Leucine; Male; Melanocyte-Stimulating Hormones; Microsomes; Mitochondria; Oxytocin; Peptide Biosynthesis; Peptides; Pituitary Gland; Pregnancy; Proline; Rats; Vasopressins

1971
[Distribution of free amino acids in plasma in patients with a chronic lymphatic and acute leukemia].
    Wiener klinische Wochenschrift, 1971, Apr-09, Volume: 83, Issue:14

    Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Citrulline; Cystine; Glutamates; Glutamine; Glycine; Histidine; Humans; Isoleucine; Leucine; Leukemia, Lymphoid; Lysine; Methionine; Ornithine; Phenylalanine; Prednisolone; Proline; Serine; Threonine; Triethylenemelamine; Tyrosine; Valine; Vincristine

1971
Inhibition of MSH release in frogs by direct application of L-proplyl-L-leucylglycinamide to the pituitary.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 137, Issue:4

    Topics: Animals; Anura; Biological Assay; Blood; Cell Aggregation; Dopamine; Epinephrine; Glycine; Heparin; Hypothalamus; Leucine; Male; Melanocyte-Stimulating Hormones; Melanocytes; Melatonin; Norepinephrine; Peptides; Pigmentation; Pituitary Gland; Proline; Rana pipiens

1971
A preliminary map of genomic sites for F-attachment in Escherichia coli K12.
    Biochemical and biophysical research communications, 1964, Oct-14, Volume: 17, Issue:3

    Topics: Adenine; Arginine; Chromosome Mapping; Chromosomes; Escherichia coli; Galactose; Histidine; In Vitro Techniques; Isoleucine; Lactose; Leucine; Lysine; Maltose; Mutation; Proline; Thiamine; Tryptophan

1964
Degeneracy in the amino acid code.
    Biochimica et biophysica acta, 1966, May-19, Volume: 119, Issue:2

    Topics: Amino Acids; Asparagine; Bacterial Proteins; Escherichia coli; Genetic Code; Glutamine; Histidine; Leucine; Lysine; Polynucleotides; Proline; Serine; Threonine

1966
Imidazolylacetolphosphate:L-glutamate aminotransferase. Composition and substructure.
    The Journal of biological chemistry, 1967, Mar-25, Volume: 242, Issue:6

    Topics: Alanine; Ammonia; Arginine; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Electrophoresis; Genes; Glycine; Histidine; Leucine; Methionine; Molecular Biology; Molecular Weight; Peptides; Phenylalanine; Proline; Salmonella typhimurium; Serine; Threonine; Transaminases; Tyrosine; Valine

1967
Inhibition of protein synthesis by bottromycin A2 and its hydrazide.
    Journal of biochemistry, 1966, Volume: 60, Issue:4

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Cytosine Nucleotides; Escherichia coli; Hydrazines; Leucine; Lysine; Phenylalanine; Polynucleotides; Proline; Valine

1966
Inhibition by mikamycins of polypeptide synthesis directed by native messengers and synthetic polynucleotides.
    Journal of biochemistry, 1966, Volume: 60, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Escherichia coli; In Vitro Techniques; Leucine; Liver; Lysine; Peptide Biosynthesis; Phenylalanine; Polynucleotides; Proline; Rats; Ribosomes; RNA, Transfer

1966
Isolation and properties of subunits of bovine pituitary luteinizing hormone.
    The Journal of biological chemistry, 1969, Oct-10, Volume: 244, Issue:19

    Topics: Amino Acids; Animals; Antigens; Arginine; Biological Assay; Carbohydrates; Carboxypeptidases; Cattle; Chromatography, Gel; Countercurrent Distribution; Dextrans; Diffusion; Electrophoresis, Disc; Immune Sera; Leucine; Luteinizing Hormone; Lysine; Methods; Molecular Weight; Pituitary Gland; Proline; Radioimmunoassay

1969
[Transport of amino acids across lymphocyte membrane in human peripheral blood].
    Bulletin de la Societe de chimie biologique, 1969, Oct-23, Volume: 51, Issue:6

    Topics: Amino Acids; Aspartic Acid; Biological Transport, Active; Cell Membrane; Glycine; Humans; Kinetics; Leucine; Lymphocytes; Lysine; Methionine; Proline; Radioisotopes; Serine; Temperature

1969
Mass spectrometry of phenylthiohydantoin (PTH) amino acids.
    Acta chemica Scandinavica, 1969, Volume: 23, Issue:5

    Topics: Alanine; Amino Acids; Chromatography, Gas; Isoleucine; Leucine; Proline; Spectrum Analysis; Valine

1969
Isosmotic regulation in isolated surviving nerves of Eriocheir sinensis Milne Edwards.
    Comparative biochemistry and physiology, 1969, Dec-15, Volume: 31, Issue:6

    Topics: Adaptation, Physiological; Amino Acids; Ammonia; Animals; Cell Membrane Permeability; Crustacea; Hypotonic Solutions; Isoleucine; Leucine; Neurons; Osmotic Pressure; Phenylalanine; Proline; Seawater; Tyrosine; Valine; Water-Electrolyte Balance

1969
[Chemical and physico-chemical properties of placental protein with antineoplastic effect].
    Antibiotiki, 1969, Volume: 14, Issue:11

    Topics: Alanine; Amino Acids; Ammonia; Antineoplastic Agents; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Electrophoresis; Female; Glutamates; Glycine; Histidine; Humans; Leucine; Lysine; Phenylalanine; Placenta; Proline; Proteins; Serine; Threonine; Tyrosine; Valine

1969
Free amino acids in plasma, red cells and anaplasmata of parasitized calves.
    Comparative biochemistry and physiology, 1969, Sep-01, Volume: 30, Issue:5

    Topics: Amino Acids; Aminobutyrates; Anaplasma; Anaplasmosis; Animals; Arginine; Aspartic Acid; Cattle; Cattle Diseases; Chromatography, Ion Exchange; Chromatography, Thin Layer; Erythrocytes; Glycine; Isoleucine; Leucine; Ornithine; Proline; Spleen; Splenectomy; Threonine

1969
Multiple forms of dipeptidases in normal human intestinal mucosa and in mucosa from children with coeliac disease.
    Clinica chimica acta; international journal of clinical chemistry, 1969, Volume: 26, Issue:3

    Topics: Amino Acid Oxidoreductases; Amino Acids; Animals; Biopsy; Celiac Disease; Child; Coloring Agents; Diarrhea; Dipeptidases; Dipeptides; Electrophoresis; Glutamate Dehydrogenase; Humans; Intestinal Mucosa; Jejunum; Leucine; Methods; Peptide Hydrolases; Proline; Snakes

1969
[On the influence of contraceptive pills on serum amino acids in comparison with results typical for sex, menstrual cycle and pregnancy].
    Archiv fur Gynakologie, 1969, Volume: 208, Issue:1

    Topics: Adult; Alanine; Amino Acids; Citric Acid Cycle; Contraceptives, Oral; Female; Glycine; Humans; Isoleucine; Leucine; Male; Menstruation; Methionine; Pregnancy; Proline; Sex Factors; Threonine; Tyrosine; Urea; Valine

1969
Proline transport into isolated rat glomeruli.
    Biochimica et biophysica acta, 1970, Jan-06, Volume: 196, Issue:1

    Topics: Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Choline; Cyanides; Dinitrophenols; Female; Freezing; Hot Temperature; Hydroxyproline; In Vitro Techniques; Iodoacetates; Kidney Glomerulus; Kinetics; Leucine; Ouabain; Proline; Rats

1970
Amino acid transport into human platelets and subsequent incorporation into protein.
    Thrombosis et diathesis haemorrhagica, 1970, Feb-28, Volume: 23, Issue:1

    Topics: Amino Acids; Biological Transport; Blood Platelets; Blood Proteins; Carbon Isotopes; Cell Membrane; Cysteine; Fibrin; Fibrinogen; Glutamates; Humans; Leucine; Lysine; Microscopy, Electron; Mitochondria; Proline; Puromycin; Serine; Thrombin; Valine

1970
A comparative study of the ultrastructure and lack of growth capacity of adult human prostate epithelium mechanically separated from its stroma.
    The Journal of pathology, 1970, Volume: 100, Issue:2

    Topics: Adult; Autoradiography; Culture Techniques; Endoplasmic Reticulum; Epithelial Cells; Humans; Leucine; Male; Microscopy, Electron; Mitochondria; Proline; Prostate; Ribosomes; Uridine

1970
Derivation of partial sequence of human beta chain messenger RNA from mutation data.
    Nature, 1970, Mar-28, Volume: 225, Issue:5239

    Topics: Alanine; Arginine; Genetic Code; Glycine; Hemoglobins; Humans; Leucine; Mutation; Nucleotides; Proline; RNA, Messenger; Serine; Threonine; Valine

1970
Hemoglobin G Georgia or alpha 2-95 Leu (G-2) beta-2.
    Biochimica et biophysica acta, 1970, Mar-31, Volume: 200, Issue:3

    Topics: Amino Acid Sequence; Amino Acids; Black or African American; Child; Chromatography, Ion Exchange; Electrophoresis; Erythrocyte Count; Erythrocytes; Georgia; Globins; Hematocrit; Hemoglobins; Hemoglobins, Abnormal; Humans; Leucine; Male; Peptides; Proline; Trypsin

1970
The intestinal absorption of some essential and non-essential amino acids in fed and fasting rats.
    Life sciences, 1970, Jan-22, Volume: 9, Issue:2

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Carbon Isotopes; Deficiency Diseases; Fasting; Glycine; Histidine; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Male; Methionine; Proline; Rats

1970
Prediction and explanation of chemical mutation sites.
    Experientia, 1970, Apr-15, Volume: 26, Issue:4

    Topics: Arginine; Asparagine; Genetic Code; Genetics, Microbial; Glycine; Leucine; Models, Chemical; Mutagens; Mutation; Nucleotides; Phenylalanine; Proline; RNA, Viral; Serine; Tobacco Mosaic Virus

1970
[Study of chemical composition and antineoplastic effect of protamines isolated from the milt of sturgeon fishes].
    Antibiotiki, 1970, Volume: 15, Issue:1

    Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Chromatography, Thin Layer; Depression, Chemical; Electrophoresis; Fishes; Glutamates; Glycine; Histidine; Leucine; Lysine; Male; Methionine; Mice; Molecular Weight; Neoplasms, Experimental; Nucleic Acids; Proline; Protamines; Sarcoma 37; Serine; Spectrum Analysis; Sulfates; Threonine; Ultraviolet Rays

1970
Inhibition of Walker 256 intramuscular carcinoma in rats by administration of L-tryptophan.
    Oncology, 1970, Volume: 24, Issue:4

    Topics: Animals; Carcinoma 256, Walker; Female; Gluconeogenesis; Histidine; Injections, Intraperitoneal; Leucine; Male; Mice; Phenylalanine; Proline; Rats; Tryptophan

1970
Changes in intestinal dipeptidase activities during fetal and neonatal development of the pig as related to the ultrastructure of mucosal cells.
    Gastroenterology, 1970, Volume: 59, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Cell Differentiation; Dipeptidases; Glutamine; Hydrogen-Ion Concentration; Intestinal Mucosa; Intestine, Small; Leucine; Microscopy, Electron; Proline; Swine

1970
The venous plasma free amino acid levels during the first hours of life. II. In a lower socio-economic group of a refugee area in Karachi, West Pakistan, with special reference to the "small for dates" syndrome.
    Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:1

    Topics: Alanine; Amino Acids; Birth Weight; Gestational Age; Glycine; Growth; Growth Disorders; Humans; Infant, Newborn; Leucine; Pakistan; Proline; Protein Deficiency; Socioeconomic Factors; Time Factors; Valine; Veins; White People

1970
Gas-liquid chromatography and mass spectrometry of deuterium-containing amino acids as their trimethylsilyl derivatives.
    Journal of chromatography, 1970, Aug-12, Volume: 50, Issue:3

    Topics: Alanine; Amino Acids; Asparagine; Chromatography, Gas; Deuterium; Glycine; Leucine; Methionine; Proline; Silicon; Spectrum Analysis; Tyrosine; Valine

1970
Changes in the concentration of specific amino acids in the serum of experimentally malnourished pigs.
    The British journal of nutrition, 1970, Volume: 24, Issue:2

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Dietary Proteins; Female; Gluconeogenesis; Glycine; Histidine; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Protein Deficiency; Serine; Swine; Threonine; Tyrosine; Valine

1970
Insulin and protein synthesis in muscle.
    Archives of biochemistry and biophysics, 1970, Volume: 140, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Carbon Isotopes; In Vitro Techniques; Insulin; Leucine; Male; Muscle Proteins; Muscles; Osmolar Concentration; Proline; Rats; Sodium

1970
Incorporation of leucine-14C and lysine-14C into protein in the developing endosperm of normal and opaque-2 corn.
    Archives of biochemistry and biophysics, 1970, Volume: 140, Issue:1

    Topics: Albumins; Carbon Isotopes; Glutamates; Leucine; Lysine; Plant Proteins; Plants; Proline; Seeds; Zea mays

1970
Metabolism of amino acids in incubated slices of mouse brain.
    Journal of neurochemistry, 1970, Volume: 17, Issue:8

    Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Brain; Carbon Isotopes; Centrifugation; Cerebellum; Cerebral Cortex; Chromatography, Paper; Glucose; Histidine; In Vitro Techniques; Leucine; Lysine; Medulla Oblongata; Mesencephalon; Mice; Oxygen Consumption; Phenylalanine; Pons; Proline; Valine

1970
Loss of proteins and other macromolecules during preparation of cell cultures for high resolution autoradiography. Quantitation by a micromethod.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1970, Volume: 18, Issue:8

    Topics: Aldehydes; Autoradiography; Cell Count; Cell Line; Choriocarcinoma; Culture Techniques; Female; Formaldehyde; Humans; Leucine; Macromolecular Substances; Methods; Microscopy, Electron; Neoplasm Proteins; Pregnancy; Proline; Protein Hydrolysates; Tritium

1970
Determination of pico-mole quantities of gamma-amino-butyric acid (GABA) and serotonin.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:3

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoradiography; Brain Chemistry; Carbon Isotopes; Cerebellum; Chromatography; Cysteine; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methods; Microchemistry; Phenylalanine; Proline; Radionuclide Imaging; Rats; Serine; Serotonin; Threonine; Tyrosine; Valine

1970
Amino acid permeability of pea chloroplasts as measured by osmotically determined reflection coefficients.
    Biochimica et biophysica acta, 1970, Jul-07, Volume: 211, Issue:1

    Topics: Alanine; Amides; Amino Acids; Cell Membrane Permeability; Chloroplasts; Glycine; Imines; Isoleucine; Leucine; Methionine; Osmolar Concentration; Osmotic Pressure; Phenylalanine; Plants; Proline; Serine; Sucrose; Threonine; Valine

1970
Comparison of the multiple forms of bovine pancreatic deoxyribonuclease.
    The Journal of biological chemistry, 1970, Nov-10, Volume: 245, Issue:21

    Topics: Acetates; Amino Acid Sequence; Amino Acids; Animals; Cattle; Cellulose; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Deoxyribonucleases; Electrophoresis; Galactose; Glucosamine; Histidine; Leucine; Mannose; Neuraminic Acids; Pancreas; Pancreatic Juice; Peptides; Proline

1970
Purity and purification of 14C-lysine.
    Analytical biochemistry, 1970, Volume: 37, Issue:2

    Topics: Autoanalysis; Carbon Isotopes; Chromatography, Ion Exchange; Leucine; Lysine; Methods; Phenylalanine; Proline; Threonine

1970
Circular dichroism of two TMV mutants with identical single amino acid replacement in different position in polypeptide chain.
    Biochemical and biophysical research communications, 1970, Nov-25, Volume: 41, Issue:4

    Topics: Amino Acid Sequence; Amino Acids; Chemical Phenomena; Chemistry; Circular Dichroism; Leucine; Mutation; Proline; Protein Denaturation; Temperature; Tobacco Mosaic Virus; Ultraviolet Rays; Viral Proteins

1970
Intestinal dipeptidases and disaccharidases in celiac disease in adults.
    Gastroenterology, 1970, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Aged; Amino Acids; Celiac Disease; Diet Therapy; Dipeptidases; Dipeptides; Feces; Female; Folic Acid; Galactosidases; Glucosidases; Glutamates; Glutens; Glycoside Hydrolases; Humans; Intestinal Mucosa; Leucine; Lipids; Male; Middle Aged; Proline; Sucrase; Valine; Xylose

1970
Isolation of enzyme-bound peptide intermediates in tyrocidine biosynthesis.
    Biochemistry, 1970, Dec-08, Volume: 9, Issue:25

    Topics: Anti-Bacterial Agents; Asparagine; Bacillus; Carbon Isotopes; Chemical Precipitation; Chromatography, Thin Layer; Esters; Leucine; Ornithine; Peptide Biosynthesis; Phenylalanine; Proline; Trichloroacetic Acid

1970
The effect on the nitrogen balance of the ratio essential-non-essential amino acids in intravenously infused solutions.
    Scandinavian journal of clinical and laboratory investigation, 1970, Volume: 26, Issue:4

    Topics: Adult; Alanine; Amino Acids; Arginine; Aspartic Acid; Blood Urea Nitrogen; Female; Glycine; Histidine; Humans; Infusions, Parenteral; Isoleucine; Leucine; Lysine; Methionine; Nitrogen; Phenylalanine; Proline; Threonine; Tryptophan; Valine

1970
A new hypothesis on the evolution of the genetic code.
    Biophysik, 1970, Volume: 7, Issue:1

    Topics: Amino Acids; Arginine; Asparagine; Biological Evolution; Cysteine; Genetic Code; Glutamine; Leucine; Lysine; Methionine; Models, Chemical; Models, Structural; Nucleotides; Proline; Serine; Threonine; Tyrosine

1970
Incorporation of 14C-leucine into brain protein in rats with hyperaminoacidemia.
    The Tohoku journal of experimental medicine, 1970, Volume: 102, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Autoanalysis; Brain; Carbon Isotopes; Female; Glycine; Histidine; Injections, Intraperitoneal; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Protein Biosynthesis; Rats; Valine

1970
[Effect of amino acids on the growth of Streptococcus lactis and biosynthesis of nisin].
    Antibiotiki, 1970, Volume: 15, Issue:8

    Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Depression, Chemical; Glutamates; Glycine; Histidine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Stimulation, Chemical; Streptococcus; Threonine; Tryptophan; Valine

1970
Lysine uptake in cultured Trypanosoma cruzi: interactions of competitive inhibitors.
    The Journal of protozoology, 1970, Volume: 17, Issue:4

    Topics: Alanine; Animals; Biological Transport; Cysteine; Glycine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Trypanosoma; Tyrosine; Valine

1970
[Hyperleucinisoleucinemia due to partial transamination defect associated with type 2 hyperprolinemia. Familial case of double aminoacidopathy].
    Annales de pediatrie, 1970, Feb-02, Volume: 17, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Auditory Cortex; Child, Preschool; Deafness; Electroencephalography; Evoked Potentials; Female; Humans; Infant; Isoleucine; Leucine; Leukocytes; Male; Proline; Retinal Degeneration; Transaminases

1970
[Comparative histological, electron microscopic, histochemical and biochemical studies on invasive tumor growth. V. Behavior of various proteolytic enzymes].
    Acta biologica et medica Germanica, 1970, Volume: 24, Issue:1

    Topics: Aminopeptidases; Animals; Brain Chemistry; Brain Neoplasms; Carcinoma, Ehrlich Tumor; Dipeptidases; Histocytochemistry; Leucine; Mice; Microscopy, Electron; Neoplasm Transplantation; Oxytocin; Peptide Hydrolases; Proline; Trypsin

1970
Unstable haemoglobin disease caused by Hb Santa Ana- 88 (F4) Leu leads to Pro.
    Haematologia, 1970, Volume: 4, Issue:2

    Topics: Acetylcholinesterase; Adenosine Triphosphate; Amino Acid Sequence; Anemia, Hemolytic; Blood Group Antigens; Blood Protein Electrophoresis; Cell Membrane Permeability; Cell Survival; Chemistry Techniques, Analytical; Child; Chromium Isotopes; Electrophoresis, Disc; Electrophoresis, Paper; Erythrocytes, Abnormal; Erythropoiesis; Glucosephosphate Dehydrogenase; Glutathione; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Hungary; Immunogenetics; Iron Isotopes; Leucine; Lipids; Male; Mutation; Proline; Pyrroles

1970
Nitrogen and amino acids in the feces of young pigs receiving a protein-free diet and diets containing graded levels of soybean oil meal or casein.
    The Journal of nutrition, 1970, Volume: 100, Issue:11

    Topics: Alanine; Amino Acids; Animals; Caseins; Chromatography, Gas; Dietary Proteins; Feces; Glutamates; Glycine max; Isoleucine; Leucine; Male; Nitrogen; Oils; Proline; Swine

1970
Patterns of neutral amino acid uptake along rat small intestine.
    Biochimica et biophysica acta, 1971, Feb-02, Volume: 225, Issue:2

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Betaine; Biological Transport, Active; Carbon Isotopes; Glycine; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Leucine; Male; Methionine; Proline; Rats; Stimulation, Chemical

1971
Quantitative ultramicroanalysis of amino acids in the form of their DNS-derivatives. II. On the use of the dansylation reaction for quantitative estimation of amino acids.
    Analytical biochemistry, 1971, Volume: 39, Issue:2

    Topics: Amino Acids; Chromatography, Thin Layer; Fluorescence; Glycine; Leucine; Mathematics; Methods; Microchemistry; Naphthalenes; Proline; Serine; Sulfonic Acids; Time Factors

1971
Nutrient media for plant-parasitic nematodes. II. Amino acid requirements of Aphelenchoides sp.
    Experimental parasitology, 1971, Volume: 29, Issue:2

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Thin Layer; Culture Media; Fungi; Germ-Free Life; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Nematoda; Nutritional Requirements; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1971
Rapid transport of protein in the optic system of the goldfish.
    Journal of neurochemistry, 1971, Volume: 18, Issue:3

    Topics: Acetylcholinesterase; Animals; Asparagine; Biological Transport; Cell Nucleus; Centrifugation, Density Gradient; Chromatography, Thin Layer; Cyprinidae; DNA; Hydrolysis; Kinetics; Leucine; Microsomes; Mitochondria; Myelin Sheath; Nerve Tissue Proteins; Optic Nerve; Oxidoreductases; Proline; Ribosomes; RNA; Synaptic Vesicles; Temperature; Tritium

1971
Cyanogen bromide fragments of human serum albumin.
    The Journal of biological chemistry, 1971, Aug-10, Volume: 246, Issue:15

    Topics: Acetamides; Alanine; Amino Acids; Aspartic Acid; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyanides; Cysteine; Electrophoresis; Formates; Guanidines; Humans; Hydrogen-Ion Concentration; Iodoacetates; Leucine; Methods; Naphthalenes; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Quaternary Ammonium Compounds; Serum Albumin; Sulfates; Sulfhydryl Reagents; Sulfonic Acids; Tetroses; Urea

1971
Isolation and properties of subunits of rat pituitary luteinizing hormone.
    Biochemistry, 1971, May-11, Volume: 10, Issue:10

    Topics: 1-Propanol; Acetates; Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Countercurrent Distribution; Cystine; Electrophoresis, Disc; Ethanol; Female; Fucose; Galactose; Glucosamine; Glycopeptides; Hexosamines; Immune Sera; Iodine Isotopes; Leucine; Luteinizing Hormone; Mannose; Molecular Weight; Ovary; Proline; Quaternary Ammonium Compounds; Rabbits; Radioimmunoassay; Rats; Sheep; Stimulation, Chemical; Sulfates; Tyrosine

1971
Essential amino acids in the culture of Leishmania tarentolae.
    The Journal of parasitology, 1971, Volume: 57, Issue:4

    Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Culture Media; Glucose; Glutamates; Glycine; Histidine; Leishmania; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1971
Serum free amino acids in piglets during the early postnatal period.
    Journal of animal science, 1971, Volume: 32, Issue:5

    Topics: Age Factors; Amino Acids; Animals; Animals, Newborn; Female; Glycine; Leucine; Lysine; Male; Maternal-Fetal Exchange; Nitrogen; Pregnancy; Proline; Swine; Time Factors

1971
Intestinal transport of amino acid residues of dipeptides. I. Influx of the glycine residue of glycyl-L-proline across mucosal border.
    The Journal of biological chemistry, 1971, Jun-10, Volume: 246, Issue:11

    Topics: Animals; Carbon Isotopes; Depression, Chemical; Diffusion; Dipeptides; Glycine; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Kinetics; Leucine; Male; Methionine; Phenylalanine; Proline; Rabbits; Sodium; Tritium

1971
Studies on the biosynthesis of gramicidin S in a cell-free system from Bacillus brevis. Further attempts to elucidate its mechanism of synthesis.
    The Biochemical journal, 1967, Volume: 105, Issue:2

    Topics: Amino Acids; Bacillus; Carbon Isotopes; Cell-Free System; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Leucine; Ornithine; Phenylalanine; Proline; Tyrothricin; Valine

1967
[Biosphere products of Sinapis alba. I. Rhizosphere products].
    Die Naturwissenschaften, 1967, Volume: 54, Issue:5

    Topics: Alanine; Amino Acids; Aminobutyrates; Arabinose; Arginine; Aspartic Acid; Citrates; Cysteine; Glucose; Glutamates; Glycine; Hexoses; Histidine; Keto Acids; Leucine; Mannose; Mustard Plant; Oxalates; Pentoses; Plants, Medicinal; Proline; Ribose; Threonine; Valine; Xylose

1967
A transport system common to imino acids and glycine.
    The Tohoku journal of experimental medicine, 1967, Volume: 93, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Glycine; Hydrogen-Ion Concentration; Hydroxyproline; In Vitro Techniques; Leucine; Mice; Proline; Temperature; Time Factors

1967
[Structure analysis of hemoglobin Köln].
    Klinische Wochenschrift, 1967, Dec-01, Volume: 45, Issue:23

    Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography, Gel; Chromatography, Paper; Glutamates; Hemoglobins, Abnormal; Histidine; Humans; Leucine; Methionine; Methods; Phenylalanine; Proline; Valine

1967
The incorporation of acetate by the chemoautotroph Thiobacillus neapolitanus strain C.
    Archiv fur Mikrobiologie, 1967, Volume: 58, Issue:2

    Topics: Acetates; Arginine; Aspartic Acid; Bacterial Proteins; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Citrates; Glutamates; Leucine; Malates; Proline; Thiobacillus

1967
Ammonia production by rumen microbes in vitro.
    Die Naturwissenschaften, 1967, Volume: 54, Issue:14

    Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Asparagine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rumen; Serine; Threonine; Tryptophan; Tyrosine; Valine

1967
Reaction of beta-propiolactone with amino acids and its specificity for methionine.
    The Biochemical journal, 1968, Volume: 106, Issue:4

    Topics: Amino Acids; Autoanalysis; Chemical Phenomena; Chemistry; Cold Temperature; Cystine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Lactones; Leucine; Lysine; Methionine; Phenylalanine; Proline; Tyrosine

1968
The action of sparsomycin and gougerotin on virus growth.
    The Journal of general virology, 1968, Volume: 2, Issue:1

    Topics: Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Carbon Isotopes; Encephalitis Viruses; Glycine; Herpesviridae; Influenza A virus; Leucine; Lysine; Molecular Biology; Newcastle disease virus; Phenylalanine; Proline; RNA, Messenger; Vaccinia virus; Virus Replication; Viruses

1968
Dipeptidyl arylamidase II of the pituitary. Properties of lysylalanyl-beta-naphthylamide hydrolysis: inhibition by cations, distribution in tissues, and subcellular localization.
    The Journal of biological chemistry, 1968, Apr-25, Volume: 243, Issue:8

    Topics: Acid Phosphatase; Alanine; Animals; Arginine; Cattle; Centrifugation, Density Gradient; Chromatography, Paper; Cytoplasm; Dipeptides; Endopeptidases; Glycine; Hydrogen-Ion Concentration; Kidney; Kinetics; Leucine; Lithium; Lysine; Lysosomes; Methionine; Naphthalenes; Nucleosides; Pituitary Gland; Potassium; Proline; Protease Inhibitors; Puromycin; Rats; Serine; Sodium; Spleen; Thyroid Gland; Tromethamine; Tyrosine

1968
Amino acid transport in kidney. Heterogeneity of alpha-aminoisobutyric uptake.
    The Journal of biological chemistry, 1968, Jun-25, Volume: 243, Issue:12

    Topics: Alanine; Amides; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Choline; Cyanides; Fluorides; Glycine; Kidney; Kinetics; Leucine; Lysine; Ouabain; Proline; Rats; Sodium; Temperature

1968
The molecular structures of vertebrate skin collagens. A comparative study.
    Acta physiologica Scandinavica. Supplementum, 1968, Volume: 309

    Topics: Amino Acids; Animals; Anura; Arginine; Autoanalysis; Biological Evolution; Cattle; Chemical Phenomena; Chemistry, Physical; Chickens; Chromatography; Collagen; Electrophoresis; Fishes; Glutamates; Glycine; Guinea Pigs; Hydrogen-Ion Concentration; Hydroxyproline; Isoleucine; Leucine; Methionine; Optical Rotatory Dispersion; Proline; Serine; Sharks; Skin; Snakes; Solubility; Temperature; Threonine; Valine

1968
Characterization of the transport of neutral amino acids by the calf lens.
    Investigative ophthalmology, 1968, Volume: 7, Issue:4

    Topics: Alanine; Amino Acids; Animals; Binding Sites; Biological Transport; Buffers; Carbon Isotopes; Cattle; Cell Membrane Permeability; Glycine; Lens, Crystalline; Leucine; Methionine; Phenylalanine; Proline; Protein Biosynthesis; Rabbits; Sarcosine; Tetraethylammonium Compounds; Tritium

1968
Effect of sodium ions on the transport of neutral amino acids by calf lens.
    Investigative ophthalmology, 1968, Volume: 7, Issue:4

    Topics: Amino Acids; Animals; Binding Sites; Buffers; Carbon Isotopes; Cattle; Cell Membrane Permeability; Glycine; Lens, Crystalline; Leucine; Methionine; Potassium; Proline; Radioisotopes; Rubidium; Sarcosine; Sodium; Sodium Isotopes; Tetraethylammonium Compounds; Thiourea

1968
A study of 2,4,6-trinitrobenzenesulfonic acid for automated amino acid chromatography.
    Clinical chemistry, 1968, Volume: 14, Issue:10

    Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Autoanalysis; Chromatography; Cystine; Glycine; Histidine; Hydrogen-Ion Concentration; Indicators and Reagents; Isoleucine; Leucine; Lysine; Methionine; Methods; Nitrobenzenes; Phenylalanine; Proline; Serine; Spectrophotometry; Sulfonic Acids; Temperature; Threonine; Tryptophan; Tyrosine; Urea; Valine

1968
Primary structure of insoluble tendon collagen. 3. Analysis of products of tryptic digestion of native collagen.
    Archives of biochemistry and biophysics, 1968, Volume: 128, Issue:1

    Topics: Achilles Tendon; Alanine; Aldehydes; Amino Acids; Animals; Arginine; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Cysteine; Electrophoresis; Glutamine; Glycine; Hexosamines; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Proline; Serine; Sulfur; Threonine; Trypsin; Tyrosine; Valine

1968
Trace metal requirements for malformin biosynthesis.
    Growth, 1968, Volume: 32, Issue:2

    Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Aspartic Acid; Aspergillus; Chromium; Cobalt; Copper; Cysteine; Glutamine; Glycine; Histidine; Iron; Isoleucine; Leucine; Lysine; Manganese; Metals; Molybdenum; Peptide Biosynthesis; Phenylalanine; Plant Growth Regulators; Proline; Serine; Trace Elements; Tryptophan; Tyrosine; Valine; Zinc

1968
Purification of the gramicidin S synthesizing activity in Bacillus brevis extracts.
    European journal of biochemistry, 1968, Volume: 5, Issue:3

    Topics: Bacillus; Carbon Isotopes; Cell-Free System; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Cold Temperature; Drug Stability; Drug Storage; Enzymes; Leucine; Ornithine; Phenylalanine; Proline; Tyrothricin; Ultrasonics; Valine; Vibration

1968
Calf and pea histone IV. I. Amino acid compositions and the identical COOH-terminal 19-residue sequence.
    The Journal of biological chemistry, 1968, Nov-25, Volume: 243, Issue:22

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Evolution; Bromine; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Plants; Proline; Serine; Threonine; Trypsin; Tyrosine; Valine

1968
Two procedures for accelerated separation of amino acids by column chromatography.
    Biochimica et biophysica acta, 1968, Dec-03, Volume: 168, Issue:3

    Topics: Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Buffers; Chromatography, Ion Exchange; Cystine; Glutamates; Glycine; Isoleucine; Leucine; Methionine; Methods; Phenylalanine; Proline; Serine; Temperature; Threonine; Tryptophan; Tyrosine; Valine

1968
Gas chromatographic behavior of trimethylsilylated phenylthiohydantoin amino acids.
    Analytical biochemistry, 1968, Oct-24, Volume: 25, Issue:1

    Topics: Alanine; Amino Acids; Arginine; Chromatography, Gas; Glutamates; Glutamine; Hydantoins; Leucine; Methionine; Methods; Methylation; Phenylalanine; Proline; Serine; Silicon; Spectrum Analysis; Tyrosine

1968
Inhibition of the protein synthesis in rabbit reticulocyte by Nivalenol, a toxic principle isolated from Fusarium nivale-growing rice.
    Journal of biochemistry, 1968, Volume: 64, Issue:4

    Topics: Alcaligenes; Animals; Bacillus; Biological Assay; Carbon Isotopes; Cell-Free System; Fusarium; Leucine; Lysine; Oryza; Phenylalanine; Proline; Protein Biosynthesis; Rabbits; Reticulocytes; Ribosomes; Serratia; Staphylococcus; Toxins, Biological

1968
Acetylation of cycloheximide by Cunninghamella blakesleeana.
    Experientia, 1968, Sep-15, Volume: 24, Issue:9

    Topics: Acetates; Anhydrides; Chromatography, Thin Layer; Cycloheximide; Fungi; Leucine; Peroxides; Proline; Vitamin D

1968
Inhibition of protein and DNA syntheses in Ehrlich ascites tumour by nivalenol, a toxic principle of Fusarium nivale-growing rice.
    Experientia, 1968, Oct-15, Volume: 24, Issue:10

    Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Depression, Chemical; DNA, Neoplasm; Fusarium; Leucine; Lysine; Male; Mice; Mycotoxins; Neoplasm Proteins; Oryza; Phenylalanine; Proline; Thymidine; Uracil

1968
Influence of protein digestion on plasma amino acid levels in sheep.
    Australian journal of biological sciences, 1968, Volume: 21, Issue:6

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Caseins; Digestion; Glutamates; Glycine; Histidine; Intestinal Mucosa; Isoleucine; Leucine; Lysine; Male; Phenylalanine; Proline; Sheep; Tyrosine; Valine

1968
[Ribosomes of the mammary gland. Isolation and the capacity to incorporate in vitro amino acids into proteins].
    Bulletin de la Societe de chimie biologique, 1968, Nov-05, Volume: 50, Issue:7

    Topics: Amino Acids; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Female; Lactation; Leucine; Liver; Mammary Glands, Animal; Phenylalanine; Pregnancy; Proline; Protein Biosynthesis; Rabbits; Ribosomes; Spectrum Analysis

1968
Analytical techniques for cell fractions. X. High-pressure ninhydrin reaction system.
    Analytical biochemistry, 1968, Oct-10, Volume: 26, Issue:1

    Topics: Amino Acids; Autoanalysis; Equipment and Supplies; Hot Temperature; Indicators and Reagents; Leucine; Methods; Miniaturization; Pressure; Proline; Spectrophotometry; Time Factors

1968
Studies on membrane transport. 3. Further characterization of amino acid systems in Hymenolepis diminuta (Cestoda).
    Comparative biochemistry and physiology, 1968, Volume: 26, Issue:2

    Topics: Absorption; Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Biological Transport; Carbon Isotopes; Cell Membrane; Cestoda; Cyclopentanes; Kinetics; Leucine; Lysine; Phenylalanine; Proline; Rats; Valine

1968
In vitro studies of protein synthesis in drosophila.
    Biochemical and biophysical research communications, 1969, Apr-29, Volume: 35, Issue:2

    Topics: Animals; Carbon Isotopes; Cattle; Cell-Free System; Drosophila; Genotype; Glutamates; Leucine; Liver; Mutation; Phenylalanine; Proline; Protein Biosynthesis; Ribosomes; RNA, Transfer; Valine

1969
Hemoglobin sabine beta 91 (F 7) leu → pro. An unstable variant causing severe anemia with inclusion bodies.
    The New England journal of medicine, 1969, 04-03, Volume: 280, Issue:14

    Topics: Adolescent; Amino Acid Sequence; Anemia, Hemolytic; Blood Protein Electrophoresis; Chromatography; Chromium Isotopes; Erythrocyte Aging; Erythrocyte Count; Erythrocytes; Female; Fetal Hemoglobin; Globins; Heinz Bodies; Heme; Hemoglobinometry; Hemoglobins, Abnormal; Hemolysin Proteins; Histocytochemistry; Humans; Leucine; Methemoglobin; Microscopy, Fluorescence; Proline; Protein Binding; Reticulocytes; Splenectomy

1969
Amino-acid receptor in larvae of Pieris brassicae (Lepidoptera).
    Nature, 1969, Mar-29, Volume: 221, Issue:5187

    Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Chemoreceptor Cells; Cysteine; Glutamates; Glycine; Insecta; Leucine; Methionine; Proline; Serine; Stimulation, Chemical

1969
Incorporation of labeled amino acids by different segments of the proximal tubules in mice kidneys.
    Laboratory investigation; a journal of technical methods and pathology, 1969, Volume: 20, Issue:4

    Topics: Animals; Kidney Tubules; Leucine; Mice; Proline; Tritium; Tyrosine

1969
Effect of glucagon on concentration of several free amino acids in plasma.
    Metabolism: clinical and experimental, 1969, Volume: 18, Issue:4

    Topics: Alanine; Amino Acids; Arginine; Citrulline; Cystine; Depression, Chemical; Fasting; Female; Glucagon; Glycine; Histidine; Humans; Leucine; Liver; Lysine; Male; Methionine; Nitrogen; Phenylalanine; Progesterone; Proline; Serine; Threonine; Tyrosine; Valine

1969
The terminal amino acid residues of ovine interstitial cell-stimulating hormone and its subunits.
    Archives of biochemistry and biophysics, 1969, Volume: 130, Issue:1

    Topics: Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Chromatography, Paper; Chromatography, Thin Layer; Female; Leucine; Luteinizing Hormone; Proline; Serine; Sheep; Thiocyanates

1969
Note on a selective test for the detection of sulphur amino acids.
    Journal of chromatography, 1969, Apr-08, Volume: 40, Issue:3

    Topics: Amino Acids; Cysteine; Cystine; Glutathione; Leucine; Methionine; Proline; Tyrosine

1969
Influence of amino acid supply on ribosomes and protein synthesis of perfused rat liver.
    The Biochemical journal, 1969, Volume: 111, Issue:5

    Topics: Amino Acids; Animals; Arginine; Asparagine; In Vitro Techniques; Isoleucine; Leucine; Liver; Lysine; Male; Methionine; Perfusion; Phenylalanine; Proline; Protein Biosynthesis; Rats; Ribosomes; RNA, Messenger; Tryptophan; Valine

1969
Pyrrolidonecarboxylyl peptidase: studies on the specificity of the enzyme.
    Archives of biochemistry and biophysics, 1969, Volume: 131, Issue:2

    Topics: Alanine; Chemical Phenomena; Chemistry; Dipeptides; Isoleucine; Leucine; Peptide Hydrolases; Phenylalanine; Proline; Pseudomonas; Pyrrolidinones; Stereoisomerism; Tyrosine; Valine

1969
Fluxes of amino acids between the rat and a cestode symbiote.
    Comparative biochemistry and physiology, 1969, Volume: 29, Issue:3

    Topics: Acetates; Amino Acids; Aminobutyrates; Animals; Brain; Carbon Isotopes; Cestoda; Digestive System; Fructose; Glucose; Intestinal Mucosa; Leucine; Liver; Lysine; Male; Muscles; Proline; Rats; Symbiosis

1969
The effect of monovalent cations on the incorporation of various amino acids in protein synthesis by isolated rat spleen nuclei.
    Biochimica et biophysica acta, 1969, Jun-17, Volume: 182, Issue:2

    Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Glycine; Leucine; Lithium; Methionine; Phenylalanine; Potassium; Proline; Protein Biosynthesis; Rats; Rubidium; Sodium; Spleen; Stimulation, Chemical; Threonine

1969
Direct synthesis of p-methoxybenzyl carbazate and p-methoxybenzyloxycarbonylamino acids using p-methoxybenzyl chloroformate as reagent.
    Experientia, 1969, Jun-15, Volume: 25, Issue:6

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Chloroform; Glutamates; Glutamine; Glycine; Hydrazines; Indicators and Reagents; Isoleucine; Leucine; Phenylalanine; Proline; Sodium Hydroxide; Stereoisomerism; Threonine; Tyrosine; Valine

1969
Statistical analysis of the distribution of amino acid residues among helical and non-helical regions in globular proteins.
    Journal of molecular biology, 1969, Jun-28, Volume: 42, Issue:3

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Chymotrypsin; Hemoglobins; Leucine; Muramidase; Myoglobin; Papain; Proline; Proteins; Ribonucleases; Statistics as Topic

1969
[Studies on the amino acid composition of some African legumes].
    Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie, 1969, Volume: 39, Issue:2

    Topics: Amino Acids; Arginine; Aspartic Acid; Canavanine; Chromatography; Cystine; Food Analysis; Glutamine; Glycine; Histidine; Hot Temperature; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Plants, Edible; Proline; Proteins; Serine; Threonine; Tryptophan; Tyrosine; Valine; Vegetables

1969
[Ribonucleic acids and polyribosomes of rabbit mammary gland during lactogenesis induced by prolactin].
    Biochimica et biophysica acta, 1969, Jul-22, Volume: 186, Issue:1

    Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; DNA; Female; Lactation; Lactose; Leucine; Mammary Glands, Animal; Pregnancy; Prolactin; Proline; Protein Biosynthesis; Rabbits; Ribosomes; RNA; Spectrophotometry; Stimulation, Chemical; Time Factors

1969
Histones in early embryogenesis.
    Experimental cell research, 1969, Volume: 57, Issue:1

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Echinodermata; Electrophoresis; Embryo, Nonmammalian; Fishes; Gels; Genetic Code; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; RNA; Serine; Threonine; Tryptophan; Tyrosine; Valine

1969
Stereochemical specificity of neutral amino acid transfer systems in rat small intestine.
    Biochimica et biophysica acta, 1969, Volume: 183, Issue:3

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Cysteine; Hydroxyproline; Ileum; Intestine, Small; Jejunum; Leucine; Methionine; Pipecolic Acids; Proline; Rats; Sarcosine; Serine; Stereoisomerism

1969
[RNA isolated from turnip yellow mosaic virus; acceptor of amino acids in the presence of bacterial enzymes].
    Bulletin de la Societe de chimie biologique, 1965, Volume: 47, Issue:8

    Topics: Alanine; Alcaligenes; Amino Acids; Arginine; In Vitro Techniques; Isoleucine; Leucine; Nucleotides; Phenylalanine; Plant Viruses; Proline; RNA, Viral; Serine; Ultracentrifugation; Valine

1965
Incorporation of amino acids into fractions of insoluble collagen. Evaluation of metabolic homogeneity of collagen fibres.
    Annales medicinae experimentalis et biologiae Fenniae, 1965, Volume: 43, Issue:4

    Topics: Amino Acids; Animals; Carbon Isotopes; Chemistry Techniques, Analytical; Chick Embryo; Chromatography, Ion Exchange; Collagen; Gelatin; Glutamates; Hydroxyproline; Leucine; Proline

1965
Optical resolution of D,L amino acids by gas chromatography and mass spectrometry.
    Biochemical and biophysical research communications, 1965, Sep-22, Volume: 20, Issue:6

    Topics: Alanine; Amino Acids; Aminobutyrates; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; Glycine; Leucine; Proline; Spectrum Analysis; Thiazoles

1965
Amino acid transport by the small intestine of the rat. The effect of amino acid pre-loading on the trans-intestinal amino acid transport by the everted sac preparation.
    Biochimica et biophysica acta, 1965, Sep-27, Volume: 109, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Glycine; In Vitro Techniques; Intestine, Small; Leucine; Lysine; Proline; Rats; Threonine

1965
The mechanism of action of plant growth substances: growth substance stimulation of amino acid incorporation into nuclear protein.
    Biochimica et biophysica acta, 1965, Sep-13, Volume: 107, Issue:2

    Topics: Amino Acids; Carbon Isotopes; Cell Nucleus; Cocos; Dactinomycin; Gibberellins; In Vitro Techniques; Indoleacetic Acids; Leucine; Phenylalanine; Plant Growth Regulators; Plants, Edible; Proline; Puromycin; RNA

1965
Amino acids in seven species of cestodes.
    The Journal of parasitology, 1966, Volume: 52, Issue:1

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cestoda; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Nitrogen; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1966
Plasma amino acids in full-term infants.
    The American journal of clinical nutrition, 1966, Volume: 19, Issue:2

    Topics: Amino Acids; Birth Weight; Chromatography, Paper; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Leucine; Phenylalanine; Proline; Valine

1966
A defined medium for growth and pigment synthesis of Micrococcus roseus.
    Canadian journal of microbiology, 1966, Volume: 12, Issue:1

    Topics: Adenine; Amines; Arginine; Culture Media; Fructose; Glutamates; Glycine; Isoleucine; Leucine; Lutein; Methionine; Mevalonic Acid; Micrococcus; Pigments, Biological; Proline; Salts; Serine; Spectrophotometry

1966
Amino acid compostion of walls from single and filamentous cells of Clostridium acidiurici.
    Journal of bacteriology, 1966, Volume: 91, Issue:4

    Topics: Alanine; Amino Acids; Aspartic Acid; Bacterial Proteins; Cell Wall; Chromatography; Clostridium; Glutamates; Glycine; In Vitro Techniques; Isomerases; Leucine; Lysine; Methionine; Oxidoreductases; Phenylalanine; Proline; Serine; Valine

1966
Postnatal changes in free amino acid pool of rat brain.
    Journal of neurochemistry, 1966, Volume: 13, Issue:7

    Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chromatography; Glutamates; Glutamine; Isoleucine; Leucine; Phenylalanine; Proline; Rats; Tyrosine; Valine

1966
Inhibition by puromycin of amino acid transport by embryonic chick bone.
    Biochimica et biophysica acta, 1966, Feb-28, Volume: 115, Issue:2

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Antimetabolites; Biological Transport, Active; Bone and Bones; Chick Embryo; In Vitro Techniques; Leucine; Proline; Puromycin

1966
Polyamide layer chromatography of DNP-amino acids.
    Journal of chromatography, 1966, Volume: 22, Issue:2

    Topics: Alanine; Amides; Arginine; Aspartic Acid; Chromatography; Dinitrophenols; Glutamates; Glycine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1966
Amino acid incorporation into protein by aseptic cell-free systems from tomato cotyledons and leaves.
    Biochimica et biophysica acta, 1966, Jul-20, Volume: 123, Issue:1

    Topics: Chloroplasts; Fruit; In Vitro Techniques; Leucine; Phenylalanine; Plant Proteins; Plants, Edible; Proline; Ribosomes; RNA, Viral

1966
Gas chromatographic separation of DNP amino acids and its application to the analysis of serum amino acids.
    Analytical biochemistry, 1966, Volume: 17, Issue:1

    Topics: Alanine; Amino Acids; Aspartic Acid; Cholesterol; Chromatography, Gas; Glutamates; Glycine; Hydroxyproline; Indicators and Reagents; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Valine

1966
Nuclear histones and early embryogenesis of the chick.
    Nature, 1966, Oct-15, Volume: 212, Issue:5059

    Topics: Alanine; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Differentiation; Cell Division; Cell Nucleus; Chick Embryo; Electrophoresis; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1966
[The liver as a regulatory organ for the plasma concentration of free amino acids. (Studies on the isolated perfused rat liver)].
    Klinische Wochenschrift, 1966, Apr-01, Volume: 44, Issue:7

    Topics: Amino Acids; Animals; Aspartic Acid; In Vitro Techniques; Isoleucine; Leucine; Liver; Perfusion; Proline; Rats; Valine

1966
In vitro studies with fluoroprolines.
    Nature, 1966, Nov-19, Volume: 212, Issue:5064

    Topics: Animals; Body Weight; Carbon Isotopes; Female; Fluorine; Glycine; Leucine; Liver; Mice; Proline; Protein Biosynthesis

1966
Free amino acids of human foetal and adult liver.
    Nature, 1966, Oct-15, Volume: 212, Issue:5059

    Topics: Adult; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Cystine; Female; Fetus; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Liver; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Proline; Serine; Taurine; Threonine; Tyrosine; Urea; Valine

1966
Changes in the amino acid composition of proteolipids of white matter during maturation of the human nervous system.
    Journal of neurochemistry, 1967, Volume: 14, Issue:1

    Topics: Adult; Aged; Amino Acids; Aspartic Acid; Central Nervous System; Child; Frontal Lobe; Humans; Infant; Infant, Newborn; Leucine; Lipoproteins; Maple Syrup Urine Disease; Phenylalanine; Proline; Tyrosine

1967
Free amino acids in gamma-irradiated carrots.
    Radiation research, 1967, Volume: 30, Issue:3

    Topics: Acetates; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Carbon Isotopes; Glutamates; Leucine; Methionine; Plants, Edible; Proline; Radiation Effects; Serine; Threonine; Tyrosine

1967
Rate constants of hydrated electron reactions with peptides and proteins.
    Radiation research, 1967, Volume: 31, Issue:1

    Topics: Alanine; Albumins; Asparagine; Electrons; Gelatin; Glycine; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Weight; Muramidase; Peptides; Phenylalanine; Proline; Proteins; Ribonucleases; Tryptophan; Tyrosine; Valine

1967
Further studies of amino acid transport by embryonic chick bone.
    The Journal of biological chemistry, 1967, Jun-10, Volume: 242, Issue:11

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Bone and Bones; Chick Embryo; Dactinomycin; Ethylmaleimide; Glycine; In Vitro Techniques; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine

1967
On the formation of amino acids by gamma-ray-induced carboxylation of amines in aqueous solutions.
    Radiation research, 1967, Volume: 31, Issue:3

    Topics: Alanine; Amines; Amino Acids; Aminobutyrates; Aspartic Acid; Carbon Dioxide; Chemistry, Organic; Cobalt Isotopes; Glutamates; Glycine; Hydrogen-Ion Concentration; Leucine; Organic Chemistry Phenomena; Proline; Radiation Effects; Valine; Water

1967
Amino-acid transport by various leucocyte preparations: a comparative survey.
    Enzymologia biologica et clinica, 1967, Volume: 8, Issue:2

    Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Cyanides; Dinitrophenols; Fluorides; Glycine; Guinea Pigs; In Vitro Techniques; Iodoacetates; Leucine; Leukocytes; Lymph Nodes; Lysine; Methionine; Proline; Serine; Spleen

1967
A new developing solvent for paper chromatography of various phenolic compounds, sugars and amino acids.
    Journal of chromatography, 1967, Volume: 26, Issue:2

    Topics: Amino Acids; Anthocyanins; Arginine; Asparagine; Carbohydrates; Chromatography, Paper; Gallic Acid; Glutamates; Histidine; Indicators and Reagents; Leucine; Lysine; Methionine; Phenols; Phenylalanine; Phloroglucinol; Proline; Resorcinols; Serine; Threonine; Tryptophan; Tyrosine; Valine

1967
Low-molecular-weight compounds in Macrocystis pyrifera, a marine alga.
    Archives of biochemistry and biophysics, 1967, Volume: 118, Issue:2

    Topics: Alanine; Alcohols; Amino Acids; Aspartic Acid; Chromatography; Eukaryota; Glutamates; Glycerol; Leucine; Proline; Succinates; Taurine; Valine

1967
The recovery of amino acids from acid hydrolysates of whole urine from patients with thermal burns.
    Clinica chimica acta; international journal of clinical chemistry, 1967, Volume: 15, Issue:3

    Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Burns; Creatine; Glutamates; Glycine; Histidine; Humans; Hydroxyproline; Isoleucine; Leucine; Lysine; Ornithine; Phenylalanine; Proline; Serine; Taurine; Threonine; Tyrosine; Urea; Valine

1967
Plasma amino acid pattern of chicks in relation to length of feeding period.
    The Journal of nutrition, 1967, Volume: 91, Issue:4

    Topics: Amino Acids; Animals; Appetite Regulation; Arginine; Birds; Cystine; Dietary Proteins; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Threonine; Tyrosine; Valine

1967
Effect of fasting and of feeding a nonprotein diet on plasma amino acid levels in the chick.
    The Journal of nutrition, 1967, Volume: 91, Issue:4

    Topics: Amino Acids; Animals; Arginine; Birds; Cystine; Diet; Dietary Proteins; Fasting; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Threonine; Tyrosine; Valine

1967
Electron microscopic and biochemical characterization of collagen in blattarian insects.
    The Journal of cell biology, 1967, Volume: 33, Issue:2

    Topics: Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Collagen; Connective Tissue Cells; Cysteine; Cystine; Female; Glutamates; Glycine; Histidine; Histocytochemistry; Hydroxyproline; Insecta; Isoleucine; Leucine; Lysine; Male; Methionine; Microscopy, Electron; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine

1967
Structural basis of kanamycin for miscoding activity.
    Biochemical and biophysical research communications, 1967, Mar-09, Volume: 26, Issue:5

    Topics: Adenine Nucleotides; Amines; Amino Acids; Amino Sugars; Arginine; Chemical Phenomena; Chemistry; Cytosine Nucleotides; DNA; Genetic Code; Isoleucine; Kanamycin; Leucine; Lysine; Phenylalanine; Polynucleotides; Proline; Serine; Threonine; Uracil Nucleotides; Valine

1967
Gluconeogenesis from amino acids in neonatal rat liver.
    The Biochemical journal, 1967, Volume: 103, Issue:3

    Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartate Aminotransferases; Aspartic Acid; Gluconeogenesis; Glutamates; Glycine; Histidine; In Vitro Techniques; Leucine; Liver; Liver Glycogen; Phenylalanine; Proline; Rats; Serine; Spectrophotometry; Threonine; Tyrosine; Valine

1967
Haemoglobin Genova: beta-28 (B10) leucine replaced by proline.
    Nature, 1967, May-27, Volume: 214, Issue:5091

    Topics: Amino Acid Sequence; Anemia, Hemolytic, Congenital; Electrophoresis; Female; Hemoglobins; Hemoglobins, Abnormal; Humans; Italy; Leucine; Proline

1967
Ergot alkaloids. I. Biosynthesis of the peptide side chain.
    Folia microbiologica, 1967, Volume: 12, Issue:5

    Topics: Alanine; Ascomycota; Carbon Isotopes; Ergot Alkaloids; Ergotamine; Leucine; Methionine; Peptide Biosynthesis; Phenylalanine; Proline; Pyruvates; Valine

1967
Repression of arginase synthesis in Chang liver cells.
    Experimental cell research, 1967, Volume: 48, Issue:1

    Topics: Animals; Arginase; Carbon Isotopes; Culture Techniques; Dactinomycin; Horses; Kinetics; Leucine; Liver; Manganese; Proline; Puromycin; RNA; RNA, Messenger; Uridine

1967
The effect of progesterone on the concentration of plasma amino acids in man.
    Metabolism: clinical and experimental, 1967, Volume: 16, Issue:12

    Topics: Acromegaly; Alanine; Amino Acids; Arginine; Citrulline; Cystine; Fasting; Glycine; Histidine; Humans; Isoleucine; Leucine; Liver; Lysine; Methionine; Ornithine; Phenylalanine; Progesterone; Proline; Proteins; Threonine; Tyrosine; Valine

1967
Relationship between the effects of contraction and insulin on the metabolism of the isolated levator ani muscle of the rat.
    Acta endocrinologica, 1967, Volume: 56

    Topics: Adenine; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Glucose; In Vitro Techniques; Insulin; Leucine; Male; Muscle Contraction; Muscle Proteins; Muscles; Proline; Rats; RNA; Tritium; Valine; Xylose

1967
The use of in vitro models for investigating the response of fibrous joints to tensile mechanical stress.
    American journal of orthodontics, 1984, Volume: 85, Issue:2

    Topics: Animals; Cell Cycle; Collagen; Cranial Sutures; Endopeptidases; Enzyme Inhibitors; Leucine; Metalloendopeptidases; Microbial Collagenase; Models, Biological; Organ Culture Techniques; Osteogenesis; Proline; Protein Biosynthesis; Rabbits; Skull; Stress, Mechanical; Tissue Inhibitor of Metalloproteinases

1984
Facilitation of morphine-induced tolerance and physical dependence by prolyl-leucyl-glycinamide.
    European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3

    Topics: Analgesia; Animals; Body Temperature; Body Weight; Brain Chemistry; Drug Tolerance; Glycine; Humans; Leucine; Male; Mice; Morphine; Morphine Dependence; MSH Release-Inhibiting Hormone; Naloxone; Proline

1981
Intestinal assimilation of a proline-containing tetrapeptide. Role of a brush border membrane postproline dipeptidyl aminopeptidase IV.
    The Journal of clinical investigation, 1983, Volume: 72, Issue:2

    Topics: Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Female; Glycine; Hydrolysis; Intestinal Absorption; Intestinal Mucosa; Kinetics; Leucine; Microvilli; Perfusion; Proline; Rats; Rats, Inbred Strains

1983
Organization of developing precruciate corticostriate projections in kittens.
    Experimental neurology, 1980, Volume: 67, Issue:2

    Topics: Aging; Animals; Axonal Transport; Brain; Cats; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Leucine; Proline; Putamen

1980
A severe hemolytic anemia related to a new case of hemoglobin Perth (Abraham Lincoln) in a French patient.
    Hemoglobin, 1980, Volume: 4, Issue:1

    Topics: 1-Propanol; Anemia, Hemolytic; Australia; Chemical Precipitation; Child; Electrophoresis, Cellulose Acetate; Fetal Hemoglobin; France; Hemoglobin A; Hemoglobins, Abnormal; Humans; Leucine; Male; Proline

1980
Autoradiographic study of ascending projections from cardiovascular sites in the nucleus tractus solitarii in the cat.
    Brain research, 1980, Mar-31, Volume: 186, Issue:2

    Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Cardiovascular System; Cats; Female; Hypothalamus; Leucine; Male; Proline

1980
Fastigio-olivary fibers in the cat as revealed by the autoradiographic tracing method.
    Brain research, 1980, Oct-20, Volume: 199, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Brain Stem; Cats; Cerebellum; Leucine; Proline; Tritium

1980
Efferent connections of the cingulate gyrus in the rhesus monkey.
    Experimental brain research, 1981, Volume: 42, Issue:3-4

    Topics: Animals; Axonal Transport; Brain; Efferent Pathways; Gyrus Cinguli; Leucine; Macaca mulatta; Proline

1981
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum.
    Nature, 1981, Jun-04, Volume: 291, Issue:5814

    Topics: Acetylcholinesterase; Animals; Axonal Transport; Caudate Nucleus; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Leucine; Naloxone; Proline; Rats; Receptors, Opioid

1981
Brainstem projections from the lateral hypothalamic area in the rat, as studied with autoradiography.
    Neuroscience letters, 1981, Jul-02, Volume: 24, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Brain Stem; Efferent Pathways; Horseradish Peroxidase; Hypothalamus; Leucine; Proline; Rats; Tritium

1981
An autoradiographic study on the terminal distribution of cerebellothalamic fibers in the cat.
    Brain research, 1981, Jun-29, Volume: 215, Issue:1-2

    Topics: Animals; Autoradiography; Axonal Transport; Cats; Cerebellum; Efferent Pathways; Leucine; Proline; Thalamus

1981
Neocortical projections of the rat anterior commissure.
    Brain research, 1981, Sep-07, Volume: 220, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Cerebral Cortex; Corpus Callosum; Functional Laterality; Hippocampus; Leucine; Male; Nerve Degeneration; Proline; Rats; Tritium

1981
Dual topographic representation of neostriatum in the globus pallidus of rats.
    Brain research, 1982, Jul-15, Volume: 243, Issue:2

    Topics: Animals; Autoradiography; Axonal Transport; Axons; Corpus Striatum; Globus Pallidus; Leucine; Male; Proline; Rats; Tritium

1982
Anatomical evidence for segregated focal groupings of efferent cells and their terminal ramifications in the cerebellothalamic pathway of the monkey.
    Brain research, 1983, Volume: 286, Issue:3

    Topics: Animals; Autoradiography; Axonal Transport; Cerebellum; Efferent Pathways; Leucine; Macaca fascicularis; Macaca mulatta; Proline; Thalamus; Tritium

1983
Brainstem and spinal projections of the deep cerebellar nuclei in the monkey, with observations on the brainstem projections of the dorsal column nuclei.
    Brain research, 1983, Volume: 286, Issue:3

    Topics: Animals; Autoradiography; Axonal Transport; Brain Stem; Cerebellar Nuclei; Efferent Pathways; Leucine; Macaca fascicularis; Macaca mulatta; Organ Specificity; Proline; Spinal Cord; Tritium

1983
Efferent projections of the visual Wulst upon the nucleus of the basal optic root in the pigeon.
    Brain research, 1983, Jul-18, Volume: 271, Issue:1

    Topics: Animals; Autoradiography; Axonal Transport; Columbidae; Efferent Pathways; Horseradish Peroxidase; Leucine; Nerve Degeneration; Optic Nerve; Proline; Tritium; Visual Cortex

1983
The F1F0-ATPase of Escherichia coli. Substitution of proline by leucine at position 64 in the c-subunit causes loss of oxidative phosphorylation.
    The Biochemical journal, 1983, Aug-01, Volume: 213, Issue:2

    Topics: Adenosine Triphosphatases; Alleles; Amino Acid Sequence; Cell Membrane; Escherichia coli; Leucine; Models, Chemical; Operon; Oxidative Phosphorylation; Proline; Proton-Translocating ATPases

1983
Evidence for a direct projection from the superior temporal gyrus to the entorhinal cortex in the monkey.
    Brain research, 1983, Sep-26, Volume: 275, Issue:2

    Topics: Afferent Pathways; Animals; Axonal Transport; Cerebral Cortex; Efferent Pathways; Hippocampus; Horseradish Peroxidase; Lectins; Leucine; Macaca fascicularis; Male; Proline; Tritium; Wheat Germ Agglutinins

1983
Distribution of primary vestibular fibers in the brainstem and cerebellum of the monkey.
    Brain research, 1984, Mar-05, Volume: 294, Issue:2

    Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Brain Stem; Cerebellum; Leucine; Macaca fascicularis; Macaca mulatta; Proline; Saimiri; Semicircular Canals; Tritium; Vestibular Nuclei

1984
In vivo biosynthesis of [35S]- and [3H]substance P in the striatum of the rat and their axonal transport to the substantia nigra.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:3

    Topics: Animals; Axonal Transport; Chromatography, High Pressure Liquid; Corpus Striatum; Leucine; Male; Methionine; Neural Pathways; Proline; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Sulfur Radioisotopes; Tritium

1984
Fastigial nucleus projections to the brain stem in beagles: pathways for autonomic regulation.
    Neuroscience, 1984, Volume: 11, Issue:2

    Topics: Animals; Autonomic Nervous System; Axonal Transport; Blood Pressure; Brain Stem; Cerebellar Nuclei; Dogs; Efferent Pathways; Electric Stimulation; Heart Rate; Leucine; Proline

1984
Intrinsic connections and architectonics of posterior parietal cortex in the rhesus monkey.
    The Journal of comparative neurology, 1982, Jan-10, Volume: 204, Issue:2

    Topics: Animals; Leucine; Macaca; Macaca mulatta; Neural Pathways; Parietal Lobe; Proline; Synaptic Transmission; Tritium

1982
Constructions of gene libraries of Rana nigromaculata and Mus musculus with cosmid pHC79.
    Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences, 1982, Volume: 25, Issue:3

    Topics: Animals; Cloning, Molecular; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; DNA, Recombinant; Genetic Complementation Test; Leucine; Mathematics; Mice; Proline; Ranidae; Selection, Genetic

1982
E.S.R. of spin-trapped radicals in gamma-irradiated polycrystalline amino acids. Chromatographic separation of radicals.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1982, Volume: 41, Issue:6

    Topics: Amino Acids; Chromatography, High Pressure Liquid; Deamination; Electron Spin Resonance Spectroscopy; Free Radicals; Gamma Rays; Isoleucine; Leucine; Proline; Valine

1982
The thalamostriatal projection in the cat.
    The Journal of comparative neurology, 1984, Mar-01, Volume: 223, Issue:3

    Topics: Animals; Autoradiography; Brain Mapping; Cats; Corpus Striatum; Horseradish Peroxidase; Lectins; Leucine; Proline; Synaptic Transmission; Thalamic Nuclei; Thalamus; Wheat Germ Agglutinins

1984
Mode of action towards oligopeptides and proteins of hydrolase H, a high-molecular-weight aminoendopeptidase from rabbit skeletal muscle.
    European journal of biochemistry, 1983, Dec-01, Volume: 137, Issue:1-2

    Topics: Aminopeptidases; Animals; Arginine; Chemical Phenomena; Chemistry; Endopeptidases; In Vitro Techniques; Leucine; Muscles; Oligopeptides; Proline; Protamines; Protease Inhibitors; Proteins; Rabbits; Substrate Specificity

1983
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidase.
    Journal of neurochemistry, 1984, Volume: 43, Issue:5

    Topics: Animals; Captopril; Dipeptides; Endopeptidases; Hydrolysis; Leucine; Neprilysin; Neurotensin; Peptide Fragments; Peptide Hydrolases; Proline; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Synaptic Membranes; Thiorphan; Tiopronin; Tyrosine

1984
[Luteinizing hormone of the sperm whale. Amino acid sequences of reduced and carboxymethylated beta-subunits].
    Biokhimiia (Moscow, Russia), 1984, Volume: 49, Issue:6

    Topics: Amino Acid Sequence; Amino Acids; Animals; Chromatography, Ion Exchange; Hydrolysis; Leucine; Luteinizing Hormone; Methylation; Oxidation-Reduction; Peptide Fragments; Proline; Whales

1984
Evidence that cycloleucine affects the high-affinity systems of amino acid uptake in cultured human fibroblasts.
    The Biochemical journal, 1984, Nov-15, Volume: 224, Issue:1

    Topics: Adenosine Triphosphate; Alanine; Amino Acids; Cells, Cultured; Cycloleucine; Depression, Chemical; Fibroblasts; Humans; Kinetics; Leucine; Proline; Sodium

1984
Stimulatory effect of platelet homogenate on amino acid transport into L-929 cells.
    Experimental pathology, 1984, Volume: 26, Issue:2

    Topics: Amino Acids; Animals; Biological Transport, Active; Blood Platelets; Cattle; Cycloheximide; L Cells; Leucine; Mice; Proline

1984
Regulation of amino acid transport in chicken embryo fibroblasts by purified multiplication-stimulating activity (MSA).
    Journal of cellular physiology, 1980, Volume: 102, Issue:1

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cell Division; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Growth Substances; Kinetics; Leucine; Lysine; Proline; Protein Biosynthesis

1980
Activation and inhibition of cerebral prolidase.
    Journal of neurochemistry, 1980, Volume: 35, Issue:2

    Topics: Animals; Brain; Cattle; Dipeptidases; Enzyme Activation; Leucine; Pepstatins; Peptides; Proline; Structure-Activity Relationship; Thyrotropin-Releasing Hormone

1980
Relationship between the two components of the split promoter of eukaryotic tRNA genes.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:6

    Topics: Caenorhabditis; DNA, Recombinant; Eukaryotic Cells; Genes; Leucine; Mutation; Operon; Plasmids; Proline; RNA Polymerase III; RNA, Transfer; Transcription, Genetic

1982
Amino acid uptake by Saccharomyces cerevisiae plasma membrane vesicles.
    Biochimica et biophysica acta, 1980, Volume: 595, Issue:1

    Topics: Amino Acids; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Membrane; Glycine; Leucine; Osmolar Concentration; Proline; Saccharomyces cerevisiae; Sodium

1980
Proteolytic susceptibility of hemoglobin synthesized in the presence of amino acid analogues.
    Molecular pharmacology, 1981, Volume: 20, Issue:1

    Topics: Amino Acids; Animals; Hemoglobins; Histidine; In Vitro Techniques; Leucine; Peptide Hydrolases; Phenylalanine; Proline; Rabbits; Reticulocytes; Tryptophan

1981
Evidence for a single multifunctional polypeptide chain on gramicidin S synthetase 2 obtained from a wild strain and mutant strains of Bacillus brevis.
    Journal of biochemistry, 1982, Volume: 91, Issue:1

    Topics: Amino Acid Isomerases; Aminoacylation; Bacillus; Binding Sites; Electrophoresis, Polyacrylamide Gel; Leucine; Molecular Weight; Multienzyme Complexes; Mutation; Ornithine; Pantothenic Acid; Peptide Synthases; Peptides; Proline; Valine

1982
Extensive destruction of newly synthesized casein in mammary explants in organ culture.
    The Biochemical journal, 1982, Jan-15, Volume: 202, Issue:1

    Topics: Animals; Caseins; Chloroquine; Cycloheximide; Fatty Acid Synthases; Female; Hexosamines; Leucine; Mammary Glands, Animal; Organ Culture Techniques; Pregnancy; Proline; Rabbits

1982
Collateral sprouting of somatosensory corticofugal axons into the cerebellar deafferented red nucleus.
    Brain research, 1982, Apr-15, Volume: 237, Issue:2

    Topics: Animals; Autoradiography; Axons; Cats; Cerebellum; Cerebral Cortex; Leucine; Proline; Red Nucleus; Tritium

1982
Studies on inherited and acquired metabolic disorders in cultured arterial smooth muscle cells and fibroblasts.
    International journal of obesity, 1982, Volume: 6 Suppl 1

    Topics: Adolescent; Adult; Cell Division; Cells, Cultured; Child; Diabetes Mellitus; Female; Fibroblasts; Humans; Leucine; Lipoproteins; Male; Middle Aged; Muscle, Smooth, Vascular; Pancreatectomy; Proline

1982
Amino acid inhibition and stimulation of 2-aminoisobutyric acid exit from anuran small intestine.
    The Journal of physiology, 1982, Volume: 327

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Epithelium; In Vitro Techniques; Intestine, Small; Leucine; Proline; Rana ridibunda

1982
The characteristic changes of amino acid transport during development in brush border membrane vesicles of the guinea pig ileum.
    Biochimica et biophysica acta, 1982, Sep-24, Volume: 691, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Guinea Pigs; Ileum; Kinetics; Leucine; Membrane Fluidity; Membrane Lipids; Microvilli; Proline; Time Factors

1982
Cerebello-olivary projections in the rat. An autoradiographic study.
    Brain, behavior and evolution, 1982, Volume: 21, Issue:1

    Topics: Animals; Autoradiography; Cerebellar Nuclei; Leucine; Olivary Nucleus; Proline; Rats; Rats, Inbred Strains; Tritium

1982
Circular dichroism of type 13 beta -turn in linear tripeptides containing L-proline and D-alanine.
    Biochemical and biophysical research communications, 1981, Sep-16, Volume: 102, Issue:1

    Topics: Alanine; Circular Dichroism; Hydrogen Bonding; Leucine; Oligopeptides; Proline; Protein Conformation; Structure-Activity Relationship; Valine

1981
Regulation of amino acid transport in Thiobacillus thioparus.
    Journal of bacteriology, 1981, Volume: 148, Issue:3

    Topics: Amino Acids; Biological Transport, Active; Genes, Bacterial; Leucine; Mutation; Proline; Thiobacillus; Transformation, Bacterial; Tryptophan

1981
Differences in glial and neuronal labeling following [3H]proline or [3H]leucine injections into the dorsal column nuclei of cats.
    Neuroscience, 1981, Volume: 6, Issue:11

    Topics: Animals; Autoradiography; Cats; Ganglia, Spinal; Leucine; Medulla Oblongata; Microscopy, Electron; Neuroglia; Neurons; Proline

1981
The transport of neutral amino acids in cultured human fibroblasts.
    The Journal of biological chemistry, 1980, Feb-10, Volume: 255, Issue:3

    Topics: Alanine; Amino Acids; Biological Transport; Cells, Cultured; Fibroblasts; Humans; Kinetics; Leucine; Osmolar Concentration; Proline; Skin

1980
Cyclic peptides. VII. Synthesis and conformation of diastereomeric analogs of cyl-2 containing L-proline and L-leucine.
    International journal of peptide and protein research, 1980, Volume: 15, Issue:2

    Topics: Amino Acid Sequence; Fungal Proteins; Leucine; Peptides, Cyclic; Proline; Protein Conformation; Stereoisomerism

1980
Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage.
    Pharmacology, 1980, Volume: 21, Issue:1

    Topics: Animals; Bone Marrow; Cartilage; Cartilage, Articular; Chick Embryo; Collagen; Glucosamine; Leucine; Osteoarthritis; Proline; Proteoglycans; Tissue Extracts

1980
Unstable hemoglobin beta 32 (B 14) Leu leads to Pro, a new case discovered in Kobe.
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1980, Volume: 43, Issue:1

    Topics: Adolescent; Amino Acid Sequence; Amino Acids; Anemia, Hemolytic, Congenital; Hemoglobins, Abnormal; Humans; Hypertension, Pulmonary; Japan; Leucine; Male; Proline

1980
A comparison of magnification functions in area 19 and the lateral suprasylvian visual area in the cat.
    Experimental brain research, 1993, Volume: 97, Issue:2

    Topics: Animals; Axonal Transport; Brain Mapping; Cats; Horseradish Peroxidase; Leucine; Macaca; Proline; Stereotaxic Techniques; Tritium; Visual Cortex; Visual Fields; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins

1993
Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
    FEBS letters, 1995, Feb-13, Volume: 359, Issue:2-3

    Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Benzoxazoles; Delavirdine; DNA Primers; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Indoles; Leucine; Molecular Sequence Data; Piperazines; Point Mutation; Proline; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase

1995
Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.
    Biochemistry, 1995, Oct-17, Volume: 34, Issue:41

    Topics: Amino Acid Sequence; Amyloidosis; Base Sequence; DNA Primers; Electrophoresis, Polyacrylamide Gel; Genes, Lethal; Genetic Variation; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysosomes; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Prealbumin; Proline; Protein Denaturation; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship

1995
Failure of intestinal amino acid absorptive mechanisms in sepsis.
    Journal of the American College of Surgeons, 1995, Volume: 181, Issue:5

    Topics: Amino Acids; Aminobutyrates; Animals; Glutamic Acid; Intestinal Absorption; Leucine; Male; Proline; Rats; Rats, Sprague-Dawley; Sepsis

1995
A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-03, Volume: 92, Issue:14

    Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cell Division; Embryo, Mammalian; Embryonic and Fetal Development; Gestational Age; Humans; Immune Sera; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Leucine; Mice; Mice, Transgenic; Point Mutation; Proinsulin; Proline

1995
Replacements of leucine 87 in human insulin receptor alter affinity for insulin.
    The Journal of biological chemistry, 1995, Sep-15, Volume: 270, Issue:37

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Membrane; DNA Primers; DNA, Complementary; Humans; Insulin; Kinetics; Leucine; Mice; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Proline; Receptor, Insulin; Recombinant Proteins; Transfection

1995
Leu110Pro substitution in the RhD polypeptide is responsible for the DVII category blood group phenotype.
    American journal of hematology, 1995, Volume: 49, Issue:1

    Topics: Amino Acid Sequence; Base Sequence; DNA Primers; DNA, Complementary; Gene Expression; Genetic Variation; Humans; Leucine; Molecular Sequence Data; Phenotype; Point Mutation; Polymerase Chain Reaction; Proline; Protein Structure, Secondary; Reticulocytes; Rh-Hr Blood-Group System

1995
Processing of the L5-67 precursor peptide and characterization of LUQIN in the LUQ neurons of Aplysia californica.
    Peptides, 1995, Volume: 16, Issue:2

    Topics: Amino Acid Sequence; Animals; Aplysia; Chromatography, High Pressure Liquid; Ganglia, Invertebrate; Leucine; Methionine; Molecular Sequence Data; Neurons; Neuropeptides; Proline; Protein Precursors; Protein Processing, Post-Translational; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tritium

1995
The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.
    Endocrinology, 1995, Volume: 136, Issue:7

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Membrane; Conserved Sequence; Fluorescent Antibody Technique; Hypothyroidism; Leucine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Receptors, Thyrotropin; Structure-Activity Relationship; Thyrotropin

1995
Leucine zipper-like domain regulates the autophosphorylation and the transforming activity of P130gag-fps.
    Biochemical and biophysical research communications, 1995, Jun-15, Volume: 211, Issue:2

    Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Embryo, Mammalian; Fusion Proteins, gag-onc; Gene Products, gag; Immunoblotting; Leucine; Leucine Zippers; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Proline; Protein-Tyrosine Kinases; Rats; Recombinant Fusion Proteins; Retroviridae; Sequence Deletion

1995
Identification and preliminary characterization of temperature-sensitive mutations affecting HlyB, the translocator required for the secretion of haemolysin (HlyA) from Escherichia coli.
    Molecular & general genetics : MGG, 1994, Nov-15, Volume: 245, Issue:4

    Topics: Adenosine Triphosphatases; Amino Acid Sequence; Aspartic Acid; ATP-Binding Cassette Transporters; Bacterial Proteins; Base Sequence; Carrier Proteins; DNA-Binding Proteins; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Glycine; Hemolysin Proteins; Leucine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Proline; Recombinant Fusion Proteins; Repressor Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Temperature; Vancomycin; Viral Proteins; Viral Regulatory and Accessory Proteins

1994
A rapid restriction site screening method for the Pro207-->Leu mutation in the lipoprotein lipase gene.
    Human mutation, 1994, Volume: 3, Issue:4

    Topics: Base Sequence; DNA Mutational Analysis; DNA Primers; DNA Restriction Enzymes; France; Genetic Testing; Humans; Hyperlipoproteinemia Type I; Leucine; Lipoprotein Lipase; Molecular Epidemiology; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proline; Quebec

1994
Hemolytically inactive C4B complement allotype caused by a proline to leucine mutation in the C5-binding site.
    The Journal of biological chemistry, 1994, Nov-04, Volume: 269, Issue:44

    Topics: Base Sequence; Binding Sites; Complement C4b; Complement C5; DNA Primers; DNA Probes; Female; Glomerulonephritis, IGA; Haplotypes; Hemolysis; Humans; Leucine; Male; Molecular Sequence Data; Pedigree; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Proline; Protein Binding

1994
Identification of the homozygous missense mutation in the lecithin:cholesterol-acyltransferase (LCAT) gene, causing LCAT familial deficiency in two French patients.
    Atherosclerosis, 1994, Volume: 105, Issue:2

    Topics: Adult; Base Sequence; Exons; Female; Homozygote; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Leucine; Male; Molecular Sequence Data; Phosphatidylcholine-Sterol O-Acyltransferase; Point Mutation; Polymerase Chain Reaction; Proline

1994
Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors.
    Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13

    Topics: Amino Acid Sequence; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Humans; Hydrogen Bonding; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Proline; Thermodynamics

1994
A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:2

    Topics: Amino Acid Sequence; Arginine Vasopressin; Base Sequence; Child, Preschool; Chromosomes, Human, Pair 20; Diabetes Insipidus; Exons; Female; Humans; Leucine; Molecular Sequence Data; Mutation; Neurophysins; Pedigree; Pituitary Gland, Posterior; Polymerase Chain Reaction; Proline; Repetitive Sequences, Nucleic Acid

1994
A prolyl endoproteinase that acts specifically on the extrinsic 18-kDa protein of photosystem II: purification and further characterization.
    Plant & cell physiology, 1994, Volume: 35, Issue:4

    Topics: Amino Acid Sequence; Chromatography, Gel; Flavobacterium; Intracellular Membranes; Leucine; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Serine Endopeptidases; Substrate Specificity; Vegetables

1994
Low-molecular-mass human salivary mucin, MG2: structure and binding of Pseudomonas aeruginosa.
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 1993, Volume: 4, Issue:3-4

    Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Fimbriae, Bacterial; Glycopeptides; Humans; Isoleucine; Leucine; Molecular Sequence Data; Mucins; Oligosaccharides; Phenylalanine; Proline; Protein Binding; Pseudomonas aeruginosa; Salivary Proteins and Peptides; Trypsin; Valine

1993
A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype.
    Blood, 1994, Feb-15, Volume: 83, Issue:4

    Topics: Adult; Amino Acid Sequence; Base Sequence; Codon; Computer Graphics; DNA; DNA Primers; Erythrocytes; Exons; Female; Globins; Humans; Leucine; Leukocytes; Male; Models, Molecular; Molecular Sequence Data; Pedigree; Point Mutation; Polymerase Chain Reaction; Proline; Protein Structure, Secondary; Thalassemia

1994
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.
    American journal of human genetics, 1994, Volume: 54, Issue:3

    Topics: Alleles; Amino Acid Sequence; Animals; Arginine; Base Sequence; Cell Line; Cells, Cultured; Child, Preschool; Chondro-4-Sulfatase; Chromosome Mapping; Consanguinity; Cysteine; DNA; DNA Primers; DNA Transposable Elements; Exons; Female; Humans; Infant; Leucine; Male; Molecular Sequence Data; Mucopolysaccharidosis VI; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Restriction Mapping; Sequence Deletion; Transfection

1994
Identification of a novel mutation (Leu 256-->Pro) in the human aldolase B gene associated with hereditary fructose intolerance.
    Human molecular genetics, 1994, Volume: 3, Issue:1

    Topics: Amino Acid Sequence; Base Sequence; Child; DNA Primers; Exons; Female; Fructose Intolerance; Fructose-Bisphosphate Aldolase; Humans; Isoenzymes; Leucine; Male; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Proline; Restriction Mapping

1994
Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse.
    Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cell Line; Gene Expression; Hyperthyroidism; Leucine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Point Mutation; Proline; Receptors, Thyrotropin; RNA, Messenger; Transfection

1994
Peritonitis impairs intestinal absorption of proline and leucine in the rat.
    The British journal of surgery, 1994, Volume: 81, Issue:3

    Topics: Animals; Femoral Artery; Intestinal Absorption; Leucine; Male; Peritonitis; Portal Vein; Proline; Rats; Rats, Sprague-Dawley

1994
Correlated disorder of the pure Pro22/Leu25 form of crambin at 150 K refined to 1.05-A resolution.
    The Journal of biological chemistry, 1994, May-13, Volume: 269, Issue:19

    Topics: Amino Acid Sequence; Leucine; Models, Molecular; Molecular Sequence Data; Plant Proteins; Proline; Protein Conformation; Temperature; X-Ray Diffraction

1994
In vitro effect of hormones and growth factors on the incorporation of [3H]leucine, [35S]sulfate and [3H]proline by chondrocytes of aging mice.
    Mechanisms of ageing and development, 1993, Dec-31, Volume: 72, Issue:3

    Topics: Aging; Animals; Autoradiography; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Glycosaminoglycans; Growth Substances; Hormones; Leucine; Male; Mice; Mice, Inbred ICR; Proline; Proteins; Sulfates; Sulfur Radioisotopes; Time Factors; Tritium

1993
Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.
    Biochemistry, 1993, Nov-16, Volume: 32, Issue:45

    Topics: Amyloid; Base Sequence; DNA Primers; Humans; Hydrogen-Ion Concentration; Leucine; Molecular Sequence Data; Mutation; Prealbumin; Proline

1993
The effect of retinoic acid on amino acid uptake and protein synthesis by lung fibroblasts.
    The Journal of biological chemistry, 1993, Nov-05, Volume: 268, Issue:31

    Topics: Amino Acids; Aminoisobutyric Acids; Biological Transport; Cycloheximide; Fibroblasts; Humans; In Vitro Techniques; Indomethacin; Leucine; Lung; Proline; Protein Biosynthesis; Tretinoin

1993
The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity.
    Molecular and cellular biology, 1993, Volume: 13, Issue:12

    Topics: Amino Acid Sequence; Animals; Cell Line; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Inhibitor of Differentiation Protein 1; Leucine; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Protein Binding; Protein Conformation; Repressor Proteins; Transcription Factors; Transfection

1993
Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1.
    Kidney international, 1993, Volume: 44, Issue:5

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; DNA, Complementary; Gene Expression Regulation; Glomerular Mesangium; Hypertrophy; Leucine; Molecular Probes; Molecular Sequence Data; Proline; Rats; Receptors, Transforming Growth Factor beta; RNA, Messenger; Thymidine; Transforming Growth Factor beta

1993
Evidence that the extracellular N-terminal domain of C5aR contains amino-acid residues crucial for C5a binding.
    European journal of haematology, 1993, Volume: 51, Issue:5

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Complement C5a; Glycosylation; GTP-Binding Proteins; Humans; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Receptor, Anaphylatoxin C5a; Receptors, Complement; Structure-Activity Relationship; Transfection

1993
Band 3 HT, a human red-cell variant associated with acanthocytosis and increased anion transport, carries the mutation Pro-868-->Leu in the membrane domain of band 3.
    The Biochemical journal, 1993, Jul-15, Volume: 293 ( Pt 2)

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acanthocytes; Anion Exchange Protein 1, Erythrocyte; Anions; Biological Transport; DNA; Humans; Leucine; Mutation; Proline

1993
Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy.
    The Journal of biological chemistry, 1993, Jan-05, Volume: 268, Issue:1

    Topics: Acyltransferases; Alleles; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Escherichia coli; Genes, Fungal; Genotype; Kinetics; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Oligodeoxyribonucleotides; Open Reading Frames; Proline; Promoter Regions, Genetic; Recombinant Proteins; Saccharomyces cerevisiae; Temperature; Thermodynamics

1993
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
    Blood, 1993, Feb-01, Volume: 81, Issue:3

    Topics: Adult; Amino Acid Sequence; Base Sequence; Blotting, Western; Cells, Cultured; Cytochrome Reductases; Cytochrome-B(5) Reductase; Enzyme Stability; Fibroblasts; Humans; Kinetics; Leucine; Male; Methemoglobinemia; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligodeoxyribonucleotides; Proline; Reference Values; Skin; Thermodynamics

1993
An alpha-spectrin mutation responsible for hereditary elliptocytosis associated in cis with the alpha v/41 polymorphism.
    Human genetics, 1993, Volume: 90, Issue:6

    Topics: Alleles; Base Sequence; DNA Mutational Analysis; Elliptocytosis, Hereditary; Female; Gene Expression; Heterozygote; Humans; Infant; Leucine; Male; Molecular Sequence Data; Pedigree; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Spectrin

1993
Cloning of genes for proline and leucine biosynthesis from Brucella abortus by functional complementation in Escherichia coli.
    Journal of general microbiology, 1993, Volume: 139, Issue:1

    Topics: 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Brucella abortus; DNA Mutational Analysis; Escherichia coli; Genes, Bacterial; Genetic Complementation Test; Glutamate-5-Semialdehyde Dehydrogenase; Leucine; Proline; Restriction Mapping

1993
Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B.
    Journal of medicinal chemistry, 1993, Mar-19, Volume: 36, Issue:6

    Topics: Cathepsin B; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Dipeptides; Kinetics; Leucine; Magnetic Resonance Spectroscopy; Papain; Proline

1993
Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus.
    Journal of virology, 1993, Volume: 67, Issue:5

    Topics: Amino Acid Sequence; Antigens, Viral; Base Sequence; Cell Line; Gene Expression Regulation, Viral; Genome, Viral; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Leucine; Leucine Zippers; Molecular Sequence Data; Plasmids; Proline; Repetitive Sequences, Nucleic Acid; RNA, Viral; Structure-Activity Relationship; Transcriptional Activation; Transfection; Virus Replication

1993
von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:5

    Topics: Adult; Alleles; Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; CHO Cells; Codon; Cricetinae; DNA; Exons; Female; Humans; Introns; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Transfection; von Willebrand Factor

1993
Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein.
    Journal of virology, 1993, Volume: 67, Issue:6

    Topics: Amino Acid Sequence; Base Sequence; DNA Mutational Analysis; HIV Envelope Protein gp41; HIV-1; Isoleucine; Leucine; Leucine Zippers; Molecular Sequence Data; Proline; Protein Conformation; Protein Structure, Secondary

1993
A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein.
    Human molecular genetics, 1993, Volume: 2, Issue:2

    Topics: Amino Acid Sequence; Base Sequence; Cell Cycle Proteins; Cells, Cultured; DNA; DNA-Binding Proteins; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Genetic Complementation Test; Humans; Leucine; Lymphocytes; Mitomycin; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Nuclear Proteins; Open Reading Frames; Proline; Protein Biosynthesis; Protein Conformation; Proteins; Recombinant Fusion Proteins; Transfection

1993
A novel mutation (Leu817Pro) causing type 2A von Willebrand disease.
    British journal of haematology, 1996, Volume: 92, Issue:1

    Topics: Base Sequence; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Proline; von Willebrand Diseases; von Willebrand Factor

1996
Determination of amino acid isotope ratios by electrospray ionization-mass spectrometry.
    Analytical biochemistry, 1995, Nov-01, Volume: 231, Issue:2

    Topics: Arginine; Ions; Leucine; Mass Spectrometry; Proline; Radioisotope Dilution Technique; Reproducibility of Results

1995
Function and membrane topology of wild-type and mutated cytochrome P-450c21.
    The Biochemical journal, 1996, May-15, Volume: 316 ( Pt 1)

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cytochrome P-450 Enzyme System; DNA Primers; Growth Hormone; Humans; Intracellular Membranes; Leucine; Microsomes; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Proline; Protein Biosynthesis; Rabbits; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Steroid 21-Hydroxylase; Swine; Transcription, Genetic; Transfection

1996
Simple tests for rhodopsin involvement in retinitis pigmentosa.
    Journal of medical genetics, 1996, Volume: 33, Issue:3

    Topics: Female; Genetic Markers; Histidine; Humans; Leucine; Male; Mutation; Pedigree; Point Mutation; Polymorphism, Restriction Fragment Length; Proline; Retinitis Pigmentosa; Rhodopsin

1996
The regulation of L-proline transport by insulin-like growth factor-I in human osteoblast-like SaOS-2 cells.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 432, Issue:3

    Topics: Amino Acids; Amino Acids, Cyclic; beta-Alanine; Biological Transport, Active; Cell Line; Cycloheximide; Humans; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor I; Kinetics; Leucine; Osteoblasts; Proline; Protein Synthesis Inhibitors

1996
Effects of amino acids on the growth of an anaerobic rumen fungus Neocallimastix sp N 13.
    Reproduction, nutrition, development, 1996, Volume: 36, Issue:3

    Topics: Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Sulfur; Animals; Fungi; Histidine; Leucine; Methionine; Proline; Rumen; Sheep; Sulfates; Sulfides

1996
Ontogenetic development of proline intestinal transport in the domestic fowl.
    British poultry science, 1996, Volume: 37, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Biological Transport, Active; Body Weight; Chickens; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Kinetics; Leucine; Male; Mercuric Chloride; Proline

1996
Evaluation of the concentration and enantiomeric purity of selected free amino acids in fermented malt beverages (beers).
    Chirality, 1996, Volume: 8, Issue:1

    Topics: Amino Acids; Beer; Chromatography, High Pressure Liquid; Fermentation; Fluorenes; Indicators and Reagents; Leucine; Phenylalanine; Proline; Reference Standards; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism

1996
Destabilizing effect of proline substitutions in two helical regions of T4 lysozyme: leucine 66 to proline and leucine 91 to proline.
    Protein science : a publication of the Protein Society, 1996, Volume: 5, Issue:4

    Topics: Circular Dichroism; Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Leucine; Muramidase; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Spectrophotometry, Ultraviolet; Urea

1996
Inhibition of alanine:glyoxylate aminotransferase 1 dimerization is a prerequisite for its peroxisome-to-mitochondrion mistargeting in primary hyperoxaluria type 1.
    The Journal of cell biology, 1996, Volume: 135, Issue:4

    Topics: Alanine Transaminase; Animals; Arginine; Biological Transport; COS Cells; Dimerization; Glycine; Humans; Hyperoxaluria, Primary; Leucine; Liver; Microbodies; Mitochondria; Point Mutation; Polymorphism, Genetic; Proline; Transaminases

1996
Synergy in protein engineering. Mutagenic manipulation of protein structure to simplify semisynthesis.
    The Journal of biological chemistry, 1996, Dec-13, Volume: 271, Issue:50

    Topics: Chemical Phenomena; Chemistry, Physical; Isoleucine; Leucine; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Engineering; Valine

1996
Substitutions of Ser for Asn-163 and Pro for Leu-264 are important for stabilization of lipase from Pseudomonas aeruginosa.
    Journal of biochemistry, 1996, Volume: 120, Issue:5

    Topics: Aspartic Acid; Enzyme Stability; Hydrogen-Ion Concentration; Leucine; Lipase; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Protein Conformation; Pseudomonas aeruginosa; Restriction Mapping; Serine

1996
Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.
    The Journal of endocrinology, 1996, Volume: 151, Issue:3

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Calcium Channel Blockers; Cell Line; Diazoxide; Dose-Response Relationship, Drug; Glucose; Glutamine; Glyceraldehyde; Glycine; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Lysine; Potassium Channels; Proline; Radioimmunoassay; Rats; Serine; Stimulation, Chemical; Verapamil

1996
Allelic variants of human calcitonin receptor in the Japanese population.
    Human genetics, 1997, Volume: 99, Issue:1

    Topics: Alleles; Cell Line; DNA Primers; Genetic Variation; Humans; Japan; Leucine; Models, Structural; Polymerase Chain Reaction; Proline; Protein Conformation; Receptors, Calcitonin; Tumor Cells, Cultured

1997
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:12

    Topics: Amino Acids; Cross-Linking Reagents; Imines; Leucine; Models, Chemical; Organophosphorus Compounds; Oxazoles; Phosphorus; Piperidines; Proline; Sulfhydryl Compounds; Thioamides

1996
Mutations of cytochrome b6 in Chlamydomonas reinhardtii disclose the functional significance for a proline to leucine conversion by petB editing in maize and tobacco.
    Plant molecular biology, 1997, Volume: 33, Issue:1

    Topics: Animals; Chlamydomonas reinhardtii; Chloroplasts; Codon; Cytochrome b Group; Cytochrome b6f Complex; Darkness; Genes, Plant; Leucine; Light; Mutagenesis, Site-Directed; Nicotiana; Oligodeoxyribonucleotides; Plant Proteins; Plants, Toxic; Polymorphism, Restriction Fragment Length; Proline; RNA Editing; Zea mays

1997
Autonomic denervations affect rates of protein synthesis through changes in the intracellular proline imino-pool and mRNA in the fasting rat submandibular gland.
    Biochemical Society transactions, 1997, Volume: 25, Issue:1

    Topics: Animals; Autonomic Nervous System; Denervation; Fasting; Leucine; Lingual Nerve; Male; Nerve Fibers; Proline; Protein Biosynthesis; Rats; Rats, Wistar; RNA, Messenger; Submandibular Gland; Sympathectomy

1997
Import of branched-chain amino acids in Saccharomyces cerevisiae.
    Folia microbiologica, 1996, Volume: 41, Issue:1

    Topics: Amino Acid Transport Systems; Amino Acids; Gene Expression Regulation, Fungal; Glutamine; Isoleucine; Leucine; Membrane Transport Proteins; Proline; Quaternary Ammonium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transformation, Genetic; Valine

1996
DL-leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salts.
    Folia microbiologica, 1996, Volume: 41, Issue:1

    Topics: Amino Acids; Drug Resistance, Microbial; Glucose; Leucine; Microbial Sensitivity Tests; Mutation; Proline; Quaternary Ammonium Compounds; Saccharomyces cerevisiae; Salts

1996
An integrin polymorphism that defines reactivity with alloantibodies generates an anchor for MHC class II peptide binding: a model for unidirectional alloimmune responses.
    Journal of immunology (Baltimore, Md. : 1950), 1997, Apr-01, Volume: 158, Issue:7

    Topics: Antigens, CD; Epitope Mapping; HLA-DR Antigens; HLA-DRB3 Chains; Humans; Integrin beta3; Isoantibodies; Leucine; Lymphocyte Activation; Models, Immunological; Peptide Fragments; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Proline; Protein Binding; Recombinant Proteins; Solubility; T-Lymphocytes

1997
Structural characterization of the products of hydroxyl-radical damage to leucine and their detection on proteins.
    The Biochemical journal, 1997, May-15, Volume: 324 ( Pt 1)

    Topics: Cataract; Chromatography, High Pressure Liquid; Crystallins; Humans; Hydroxyl Radical; Indicators and Reagents; Lens, Crystalline; Leucine; Lipoproteins; o-Phthalaldehyde; Oligopeptides; Oxidation-Reduction; Proline; Schiff Bases; Valine

1997
RAS2/PKA pathway activity is involved in the nitrogen regulation of L-leucine uptake in Saccharomyces cerevisiae.
    The international journal of biochemistry & cell biology, 1997, Volume: 29, Issue:3

    Topics: Amino Acid Transport Systems; Amino Acids; Biological Transport; Culture Media; Cyclic AMP-Dependent Protein Kinases; Fungal Proteins; Genes, Dominant; Kinetics; Leucine; Membrane Transport Proteins; Mutation; Nitrogen; Proline; ras Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

1997
The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity.
    Journal of bacteriology, 1997, Volume: 179, Issue:15

    Topics: Alleles; Carboxy-Lyases; Cloning, Molecular; Conserved Sequence; Epitopes; Gene Expression; Genes, Fungal; Leucine; Mevalonic Acid; Point Mutation; Proline; Saccharomyces cerevisiae; Temperature

1997
Visual and chemical release of feeding behavior in adult rainbow trout.
    Chemical senses, 1997, Volume: 22, Issue:4

    Topics: Alanine; Amino Acids; Animals; Arginine; Betaine; Bites and Stings; Dose-Response Relationship, Drug; Feeding Behavior; Glycine; Leucine; Movement; Olfactory Pathways; Oncorhynchus mykiss; Photic Stimulation; Proline; Propionates; Reproducibility of Results; Stimulation, Chemical; Swimming; Taste; Valine

1997
Intestinal absorption of proline and leucine in chronically catheterized rats.
    Gastroenterology, 1997, Volume: 113, Issue:3

    Topics: Anesthesia; Animals; Catheterization; Intestinal Absorption; Intestinal Mucosa; Laparotomy; Leucine; Male; Proline; Rats; Rats, Sprague-Dawley; Time Factors

1997
Oxidative protein damage and degradation in lymphocytes from patients infected with human immunodeficiency virus.
    The Journal of infectious diseases, 1997, Volume: 176, Issue:3

    Topics: Adult; CD3 Complex; DNA; HIV Infections; Humans; Interleukin-2; Leucine; Lymphocyte Activation; Lymphocytes; Middle Aged; Oxidative Stress; Proline; Reactive Oxygen Species; Receptors, Interleukin-2; Superoxide Dismutase; Superoxides

1997
Molecular epidemiology of hepatitis B virus in Central America reflected in the genetic variability of the small S gene.
    The Journal of infectious diseases, 1997, Volume: 176, Issue:4

    Topics: Amino Acid Sequence; Central America; DNA, Viral; Genes, Viral; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Leucine; Molecular Epidemiology; Molecular Sequence Data; Phylogeny; Point Mutation; Polymerase Chain Reaction; Proline; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Threonine

1997
FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.
    The Journal of biological chemistry, 1997, Oct-31, Volume: 272, Issue:44

    Topics: Amino Acid Sequence; Calcineurin; Calcium Channels; Carrier Proteins; DNA-Binding Proteins; Heat-Shock Proteins; Inositol 1,4,5-Trisphosphate Receptors; Leucine; Molecular Sequence Data; Proline; Protein Binding; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Saccharomyces cerevisiae; Tacrolimus; Tacrolimus Binding Proteins

1997
A new mutation in the human lipoprotein lipase gene causing familial hyperchylomicronaemia.
    Molecular pathology : MP, 1997, Volume: 50, Issue:4

    Topics: Child; Exons; Female; Humans; Hyperlipoproteinemia Type I; Infant, Newborn; Leucine; Lipoprotein Lipase; Male; Point Mutation; Polymerase Chain Reaction; Proline

1997
Chicken rotavirus Ch-1 shows a second type of avian VP6 gene.
    Virus genes, 1997, Volume: 15, Issue:1

    Topics: Amino Acid Sequence; Animals; Antigens, Viral; Base Sequence; Capsid; Capsid Proteins; Chickens; Genes, Viral; Genetic Variation; Leucine; Molecular Sequence Data; Mutation; Phylogeny; Proline; Rotavirus; Sequence Homology, Amino Acid; Viral Structural Proteins

1997
Expression cloning of a mammalian amino acid transporter or modifier by complementation of a yeast transport mutant.
    Journal of cellular physiology, 1997, Volume: 173, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Transport Systems; Aminoisobutyric Acids; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; Cloning, Molecular; DNA, Complementary; Gene Library; Genetic Complementation Test; Kinetics; Leucine; Male; Mammals; Mice; Molecular Sequence Data; Muscle, Skeletal; Organ Specificity; Polymerase Chain Reaction; Proline; Protein Biosynthesis; Rats; Recombinant Proteins; RNA, Messenger; Saccharomyces cerevisiae; Transcription, Genetic

1997
Subunit interactions of Escherichia coli F1-ATPase: mutants of the gamma subunits defective in interaction with the epsilon subunit isolated by the yeast two-hybrid system.
    Archives of biochemistry and biophysics, 1997, Dec-01, Volume: 348, Issue:1

    Topics: Amino Acid Substitution; beta-Galactosidase; Escherichia coli; Genes, Reporter; Glutamine; Kinetics; Leucine; Macromolecular Substances; Methionine; Mutagenesis, Site-Directed; Operon; Plasmids; Proline; Proton-Translocating ATPases; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sequence Deletion; Threonine; Valine

1997
Relationships between H-NS, sigma S, SpvR and growth phase in the control of spvR, the regulatory gene of the Salmonella plasmid virulence operon.
    Molecular & general genetics : MGG, 1997, Volume: 256, Issue:4

    Topics: Bacterial Proteins; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Regulator; Leucine; Models, Genetic; Mutagenesis; Nuclear Proteins; Nucleic Acid Conformation; Operon; Plasmids; Proline; Promoter Regions, Genetic; Salmonella typhimurium; Sigma Factor; Transcription, Genetic; Virulence

1997
From ribonuclease A toward bovine seminal ribonuclease: a step by step thermodynamic analysis.
    Biochemistry, 1997, Nov-25, Volume: 36, Issue:47

    Topics: Animals; Calorimetry, Differential Scanning; Cattle; Circular Dichroism; Cysteine; Endoribonucleases; Leucine; Male; Models, Chemical; Mutagenesis, Insertional; Proline; Recombinant Proteins; Ribonuclease, Pancreatic; Semen; Thermodynamics

1997
SHBG region of the anticoagulant cofactor protein S: secondary structure prediction, circular dichroism spectroscopy, and analysis of naturally occurring mutations.
    Proteins, 1997, Volume: 29, Issue:4

    Topics: Amino Acid Sequence; Animals; Cattle; Cell Membrane; Circular Dichroism; Complement C4b; DNA Mutational Analysis; Haplorhini; Histocompatibility Antigens; Humans; Leucine; Mice; Molecular Sequence Data; Mutation; Proline; Protein S; Protein S Deficiency; Protein Structure, Secondary; Rabbits; Rats; Receptors, Steroid; Sequence Homology, Amino Acid; Sex Hormone-Binding Globulin; Solvents; Swine

1997
[D-category VII depends on amino acid substitution Leu(110)Pro].
    Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1997, Volume: 34

    Topics: Amino Acid Substitution; Blood Donors; Genetic Carrier Screening; Humans; Isoantibodies; Leucine; Mass Screening; Point Mutation; Proline

1997
Missense mutations in codon 225 of ornithine transcarbamylase (OTC) result in decreased amounts of OTC protein: a hypothesis on the molecular mechanism of the OTC deficiency.
    Journal of inherited metabolic disease, 1997, Volume: 20, Issue:6

    Topics: Animals; Base Sequence; Codon; Deoxyribonuclease HpaII; Enzyme Stability; Exons; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Leucine; Liver; Mice; Molecular Sequence Data; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Polymerase Chain Reaction; Proline; Rats; Sequence Analysis, DNA

1997
Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae.
    The Journal of biological chemistry, 1998, Jan-30, Volume: 273, Issue:5

    Topics: Amino Acid Transport Systems; Amino Acids; Amino Acids, Cyclic; Biological Transport; Carrier Proteins; Escherichia coli Proteins; Leucine; Membrane Transport Proteins; Proline; Saccharomyces cerevisiae; Sphingosine

1998
Role of hydrophobic amino acids in gurmarin, a sweetness-suppressing polypeptide.
    Biopolymers, 1998, Volume: 45, Issue:3

    Topics: Amino Acid Sequence; Amino Acids; Animals; Disulfides; Drug Interactions; Glutamine; Glycine; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Plant Proteins; Proline; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sweetening Agents; Taste; Tryptophan; Tyrosine

1998
Glycoprotein IIb Leu214Pro mutation produces glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa.
    Blood, 1998, Mar-01, Volume: 91, Issue:5

    Topics: Animals; Bleeding Time; Blood Platelets; CHO Cells; Cricetinae; Dual Specificity Phosphatase 2; Fibrinogen; Humans; Immunosorbent Techniques; Leucine; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Thrombasthenia; Transfection

1998
Pulmonary manifestations of Gaucher disease: an increased risk for L444P homozygotes?
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:3 Pt 1

    Topics: Adolescent; Adult; Blood Gas Monitoring, Transcutaneous; Cause of Death; Child; Child, Preschool; Echocardiography; Female; Gaucher Disease; Genotype; Homozygote; Humans; Hypertension, Pulmonary; Infant; Italy; Leucine; Lung; Lung Diseases; Lung Diseases, Interstitial; Male; Middle Aged; Oxygen; Oxygen Consumption; Pneumonia, Aspiration; Point Mutation; Proline; Prospective Studies; Respiratory Function Tests; Risk Factors; Tomography, X-Ray Computed; Vascular Diseases

1998
Analysis of the CFTR gene in Turkish cystic fibrosis patients: identification of three novel mutations (3172delAC, P1013L and M1028I).
    Human genetics, 1998, Volume: 102, Issue:2

    Topics: Adenine; Amino Acid Substitution; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosine; Frameshift Mutation; Humans; Isoleucine; Leucine; Methionine; Mutation; Polymorphism, Genetic; Proline; Sequence Deletion; Turkey

1998
A leucine zipper-like domain is essential for dimerization and encapsidation of bluetongue virus nucleocapsid protein VP4.
    Journal of virology, 1998, Volume: 72, Issue:4

    Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Binding Sites; Bluetongue virus; Capsid; Capsid Proteins; Carrier Proteins; Cell Line; Dimerization; Escherichia coli Proteins; Leucine; Leucine Zippers; Maltose-Binding Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Proline; Recombinant Fusion Proteins; Spodoptera; Viral Core Proteins; Virion; Virus Assembly

1998
Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.
    The Journal of biological chemistry, 1998, May-22, Volume: 273, Issue:21

    Topics: Amino Acid Substitution; Animals; Antigens, Nuclear; Base Sequence; Catalysis; DNA Helicases; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Complementary; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Ku Autoantigen; Leucine; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins; Proline; Protein Serine-Threonine Kinases; Radiation Tolerance; Recombination, Genetic; Tumor Cells, Cultured

1998
Familial hemolytic anemia due to Hb Sabine [beta 91(F7)Leu-->Pro] identified by polymerase chain reaction.
    Hemoglobin, 1998, Volume: 22, Issue:3

    Topics: Adult; Amino Acid Substitution; Anemia, Hemolytic, Congenital; Female; Globins; Hemoglobins, Abnormal; Humans; Infant, Newborn; Leucine; Male; Point Mutation; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Hematologic; Proline

1998
Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations.
    Bio/technology (Nature Publishing Company), 1995, Volume: 13, Issue:9

    Topics: Alleles; Animals; Cell Line; Codon; Embryo, Mammalian; Gene Targeting; Genetic Vectors; Gerstmann-Straussler-Scheinker Disease; Humans; Leucine; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Prions; Proline; Protein Engineering; Stem Cells

1995
Interactions of proline, serine, and leucine with isolated spinach thylakoids: solute loading during freezing is not related to membrane fluidity.
    Cryobiology, 1998, Volume: 37, Issue:1

    Topics: Leucine; Membrane Fluidity; Membrane Proteins; Plant Proteins; Proline; Protein Binding; Serine; Spinacia oleracea

1998
Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members.
    Oncogene, 1998, Aug-06, Volume: 17, Issue:5

    Topics: Apoptosis; Arginine; Cell Division; Cysteine; DNA Probes; Humans; Leucine; Li-Fraumeni Syndrome; Mutagenesis, Site-Directed; Neoplasm Proteins; Nuclear Proteins; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome.
    Oncogene, 1998, Aug-06, Volume: 17, Issue:5

    Topics: Arginine; Circular Dichroism; Cysteine; Germ-Line Mutation; Humans; Leucine; Li-Fraumeni Syndrome; Nuclear Magnetic Resonance, Biomolecular; Proline; Protein Structure, Secondary; Tumor Suppressor Protein p53

1998
The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils.
    The Journal of biological chemistry, 1998, Sep-18, Volume: 273, Issue:38

    Topics: Amino Acid Sequence; Amyloid Neuropathies; Computer Simulation; Crystallography, X-Ray; Genetic Variation; Humans; Leucine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Point Mutation; Prealbumin; Proline; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins

1998
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).
    Journal of neuropathology and experimental neurology, 1998, Volume: 57, Issue:9

    Topics: Adult; Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cerebellum; Dentate Gyrus; Down Syndrome; Entorhinal Cortex; Female; Hippocampus; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Point Mutation; Poland; Presenilin-1; Proline

1998
Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV.
    Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20

    Topics: Amino Acid Substitution; Animals; Anti-HIV Agents; Cell Line; Delavirdine; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Leucine; Mice; Proline; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfides

1998
Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:10

    Topics: Adult; Aged; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Genotype; Humans; Japan; Leucine; Middle Aged; Osteoporosis; Polymorphism, Genetic; Postmenopause; Proline; Protein Sorting Signals; Sequence Analysis, DNA; Transforming Growth Factor beta

1998
Proline, leucine, and alanine transport in placental microvillous membrane vesicles prepared from late gestational rats.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:10

    Topics: Alanine; Animals; Biological Transport; Female; Kinetics; Leucine; Microscopy, Electron; Microvilli; Placenta; Pregnancy; Pregnancy, Animal; Proline; Rats; Rats, Wistar

1998
Mutation analysis of Wilson disease in Taiwan and description of six new mutations.
    Human mutation, 1998, Volume: 12, Issue:6

    Topics: Alleles; Alternative Splicing; Amino Acid Substitution; Arginine; Aspartic Acid; DNA; DNA Mutational Analysis; Glutamine; Glycine; Hepatolenticular Degeneration; Humans; Leucine; Leukocytes; Mutation; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Proline; Taiwan

1998
A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer disease.
    Annales de genetique, 1998, Volume: 41, Issue:3

    Topics: Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Humans; Leucine; Membrane Proteins; Mexico; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Presenilin-1; Proline

1998
Impaired cotranslational processing as a mechanism for type I antithrombin deficiency.
    Blood, 1998, Dec-15, Volume: 92, Issue:12

    Topics: Adult; Amino Acid Substitution; Animals; Antithrombins; Cell-Free System; COS Cells; DNA Mutational Analysis; Dogs; Female; Gene Expression; Glycosylation; Humans; Leucine; Microsomes; Pancreas; Point Mutation; Proline; Protein Processing, Post-Translational; Protein Sorting Signals; Transfection

1998
Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.
    Biochemistry, 1998, Dec-22, Volume: 37, Issue:51

    Topics: Amyloid; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Leucine; Methionine; Molecular Weight; Prealbumin; Proline; Protein Conformation; Protein Denaturation; Ultracentrifugation; Valine

1998
Adenosine inhibits collagen and total protein synthesis in vascular smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:1 Pt 2

    Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; Aorta, Abdominal; Cells, Cultured; Collagen; Cyclic AMP; Dipyridamole; Kinetics; Leucine; Male; Muscle, Smooth, Vascular; Proline; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Xanthines

1999
Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis.
    Brain : a journal of neurology, 1999, Volume: 122 ( Pt 2)

    Topics: Adult; Amyloid Neuropathies; Ependyma; Exons; Female; Gadolinium; Genetic Variation; Humans; Iodine Radioisotopes; Kidney; Leucine; Liver; Magnetic Resonance Imaging; Meninges; Phenotype; Point Mutation; Polymorphism, Genetic; Prealbumin; Proline; Radionuclide Imaging; Sequence Analysis, DNA; Serum Amyloid P-Component; Spleen

1999
Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation.
    Biochemistry, 1999, Mar-16, Volume: 38, Issue:11

    Topics: Amino Acid Substitution; Animals; Circular Dichroism; Drug Resistance; Endopeptidase K; Escherichia coli; Leucine; Mice; Mice, Inbred BALB C; Prion Diseases; Prions; Proline; Protein Structure, Secondary; Recombinant Proteins

1999
Growth characteristics of Escherichia coli HB101[pGEc47] on defined medium.
    Biotechnology and bioengineering, 1998, Apr-05, Volume: 58, Issue:1

    Topics: Bacteriological Techniques; Culture Media; Escherichia coli; Leucine; Metals; Proline; Recombination, Genetic; Vitamins; Yeasts

1998
Fiber system linking the mid-dorsolateral frontal cortex with the retrosplenial/presubicular region in the rhesus monkey.
    The Journal of comparative neurology, 1999, May-03, Volume: 407, Issue:2

    Topics: Animals; Axonal Transport; Frontal Lobe; Gyrus Cinguli; Hippocampus; Leucine; Macaca mulatta; Nerve Fibers; Neurons; Proline; Tritium

1999
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
    Neuroscience letters, 1999, Mar-26, Volume: 263, Issue:2-3

    Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Apolipoprotein E4; Apolipoproteins E; Exons; Female; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Proline; Reference Values; Registries; Risk Factors; United States

1999
A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1.
    European journal of endocrinology, 1999, Volume: 140, Issue:5

    Topics: Antisense Elements (Genetics); Codon; Exons; Female; Humans; Leucine; Middle Aged; Multiple Endocrine Neoplasia Type 1; Mutation; Mutation, Missense; Neoplasm Proteins; Pedigree; Polymorphism, Restriction Fragment Length; Proline; Proto-Oncogene Proteins

1999
Molecular characterisation of the defective alpha 1-antitrypsin alleles PI Mwurzburg (Pro369Ser), Mheerlen (Pro369Leu), and Q0lisbon (Thr68Ile).
    European journal of human genetics : EJHG, 1999, Volume: 7, Issue:3

    Topics: Adult; Alleles; alpha 1-Antitrypsin; Animals; Child; Female; Gene Expression; Humans; Isoleucine; Leucine; Male; Mice; Pedigree; Proline; Serine; Serine Proteinase Inhibitors; Threonine

1999
A comparison of 15N proline and 13C leucine for monitoring protein biosynthesis in the skin.
    Amino acids, 1999, Volume: 16, Issue:2

    Topics: Animals; Carbon Isotopes; Leucine; Nitrogen Isotopes; Proline; Protein Biosynthesis; Rabbits; Radioactive Tracers; Skin; Time Factors

1999
Mutation of the N-terminal proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin.
    FEBS letters, 1999, May-07, Volume: 450, Issue:3

    Topics: Acetyltransferases; Bacterial Proteins; Bleomycin; Drug Resistance, Microbial; Escherichia coli; Leucine; Mutagenesis, Site-Directed; Proline; Recombinant Fusion Proteins; Streptomyces

1999
Two novel missense mutations causing adrenoleukodystrophy in Italian patients.
    Molecular and cellular probes, 1999, Volume: 13, Issue:3

    Topics: Adrenoleukodystrophy; Adult; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Child; Female; Humans; Italy; Leucine; Male; Membrane Proteins; Mutation, Missense; Pedigree; Proline; Serine

1999
Genetic association studies in coronary disease: the cause of GPIIb-IIIa polymorphisms.
    European heart journal, 1999, Volume: 20, Issue:10

    Topics: Coronary Disease; Humans; Leucine; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Proline

1999
Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells.
    European journal of pharmacology, 1999, Jul-28, Volume: 378, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; DNA; Drugs, Chinese Herbal; Flavanones; Flavonoids; In Vitro Techniques; Leucine; Liver; Male; Nucleic Acid Synthesis Inhibitors; Peptide Biosynthesis; Plant Roots; Proline; Rats; Rats, Sprague-Dawley; Thymidine; Tritium

1999
Leu518Pro mutation of the beta ig-h3 gene causes lattice corneal dystrophy type I.
    American journal of ophthalmology, 1999, Volume: 128, Issue:1

    Topics: Adolescent; Adult; Base Sequence; Cornea; Corneal Dystrophies, Hereditary; DNA; Exons; Extracellular Matrix Proteins; Female; Humans; Keratoplasty, Penetrating; Leucine; Male; Middle Aged; Molecular Sequence Data; Neoplasm Proteins; Pedigree; Point Mutation; Proline; Transforming Growth Factor beta

1999
Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.
    Molecular and cellular biology, 1999, Volume: 19, Issue:10

    Topics: Animals; Binding Sites; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; DNA-Binding Proteins; Goosecoid Protein; Homeodomain Proteins; Host Cell Factor C1; Leucine; Mesoderm; Mutation; Octamer Transcription Factor-1; Peptide Fragments; Proline; Protein Binding; Receptors, Glucocorticoid; Repressor Proteins; Tissue Distribution; Transcription Factors; Zebrafish; Zebrafish Proteins

1999
Activation of recombinant bovine matrix metalloproteinase-20 and its hydrolysis of two amelogenin oligopeptides.
    European journal of oral sciences, 1999, Volume: 107, Issue:5

    Topics: Alanine; Ameloblasts; Amelogenin; Amino Acids; Animals; Calcium; Cattle; Chromatography, Affinity; Chromatography, Ion Exchange; Dental Enamel Proteins; Dialysis; Enzyme Activation; Escherichia coli; Gene Expression Regulation, Enzymologic; Genetic Vectors; Hydrolysis; Leucine; Mass Spectrometry; Matrix Metalloproteinase 20; Matrix Metalloproteinases; Proline; Recombinant Proteins; Tryptophan; Zinc

1999
The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions.
    Biochemistry, 1999, Oct-12, Volume: 38, Issue:41

    Topics: Amyloid; Amyloid Neuropathies; Anilino Naphthalenesulfonates; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Leucine; Microscopy, Electron; Prealbumin; Proline; Protein Binding; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Surface Properties; Ultracentrifugation

1999
Identification of two novel mutations in keratin 13 as the cause of white sponge naevus.
    Oral diseases, 1999, Volume: 5, Issue:4

    Topics: Adolescent; Amino Acid Motifs; Amino Acid Substitution; Child; Female; Hamartoma; Humans; Keratins; Leucine; Male; Methionine; Mouth Mucosa; Mucous Membrane; Pedigree; Point Mutation; Proline; Threonine; Vagina

1999
Inheritance of two different alleles of the low-density lipoprotein (LDL)-receptor gene carrying the recurrent Pro664Leu mutation in a patient with homozygous familial hypercholesterolaemia.
    Clinical genetics, 1999, Volume: 56, Issue:3

    Topics: Alleles; Base Sequence; DNA Primers; Female; Genetic Markers; Homozygote; Humans; Hyperlipoproteinemia Type II; Leucine; Male; Microsatellite Repeats; Pedigree; Point Mutation; Proline; Receptors, LDL

1999
Expression and function of the gonadotropin-releasing hormone receptor are dependent on a conserved apolar amino acid in the third intracellular loop.
    The Journal of biological chemistry, 1999, Dec-10, Volume: 274, Issue:50

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Conserved Sequence; COS Cells; Gonadotropin-Releasing Hormone; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Kinetics; Leucine; Mice; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Structure, Secondary; Radioligand Assay; Receptors, LHRH; Transfection; Tyrosine

1999
Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D.
    Journal of virology, 2000, Volume: 74, Issue:3

    Topics: Amino Acid Substitution; Antibodies, Monoclonal; Cell Adhesion Molecules; Cell Line; Herpesvirus 1, Human; Humans; Leucine; Mutation; Nectins; Proline; Protein Isoforms; Protein Structure, Tertiary; Receptors, Virus; Transfection; Viral Envelope Proteins

2000
[Heterozygous protein C deficiency: apropos of 2 cases with cerebral venous thrombosis in the neonatal period].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2000, Volume: 7, Issue:2

    Topics: Cerebral Hemorrhage; Cerebral Veins; Follow-Up Studies; Heterozygote; Humans; Infant, Newborn; Intracranial Thrombosis; Leucine; Male; Mutation; Proline; Protein C; Protein C Deficiency; Renal Veins; Sinus Thrombosis, Intracranial; Treatment Outcome; Venous Thrombosis

2000
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:4

    Topics: Birth Weight; Child; Child, Preschool; Cholesterol; Fasting; Female; Humans; Leucine; Lipids; Male; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Sex Characteristics; Triglycerides

2000
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
    Neuroscience letters, 2000, Jun-16, Volume: 287, Issue:1

    Topics: Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Female; Genotype; Humans; Leucine; Male; Neuropeptide Y; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals

2000
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:6

    Topics: Aged; Amino Acid Substitution; Arteriosclerosis; Autonomic Nervous System; Blood Pressure; Carotid Stenosis; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Genotype; Heart Rate; Humans; Leucine; Male; Neuropeptide Y; Polymorphism, Genetic; Proline; Risk Factors

2000
Neuropeptide Y polymorphism and alcohol consumption in middle-aged men.
    American journal of medical genetics, 2000, Jul-17, Volume: 93, Issue:2

    Topics: Adult; Alcohol Drinking; Amino Acid Substitution; Data Interpretation, Statistical; DNA; Finland; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline; Protein Precursors; Protein Sorting Signals

2000
A novel missense mutation (P191L) in the glucose-6-phosphate translocase gene identified in a Chinese family with glycogen storage disease 1b.
    Human mutation, 2000, Volume: 16, Issue:1

    Topics: Amino Acid Substitution; Antiporters; Glycogen Storage Disease Type I; Hong Kong; Humans; Leucine; Monosaccharide Transport Proteins; Mutation, Missense; Phosphotransferases; Proline

2000
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen.
    Blood, 2000, Jul-01, Volume: 96, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Cell Line; Child, Preschool; COS Cells; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Kidney; Leucine; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Pedigree; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thrombasthenia; Transfection; Xenopus

2000
Altered intestinal transport of amino acids in cirrhotic rats: the effect of insulin-like growth factor-I.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:2

    Topics: Amino Acids; Animals; Cysteine; Glutamic Acid; Insulin-Like Growth Factor I; Intestinal Absorption; Jejunum; Kinetics; Leucine; Liver Cirrhosis, Experimental; Malabsorption Syndromes; Male; Microvilli; Nutrition Disorders; Proline; Rats; Rats, Wistar

2000
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2000, Volume: 108, Issue:3

    Topics: Aged; Amino Acid Substitution; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Finland; Follow-Up Studies; Glycated Hemoglobin; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Time Factors

2000
Association of a Leu(10)-->Pro polymorphism of the transforming growth factor-beta1 with genetic susceptibility to osteoporosis and spinal osteoarthritis.
    Mechanisms of ageing and development, 2000, Jul-31, Volume: 116, Issue:2-3

    Topics: Animals; Bone Density; Disease Susceptibility; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Osteoarthritis; Osteoporosis; Polymorphism, Genetic; Proline; Radius; Transforming Growth Factor beta; Transforming Growth Factor beta1; Treatment Outcome

2000
The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: Amino Acid Substitution; Amyloidosis; Benzothiazoles; Crystallization; Doxorubicin; Humans; Iodine; Leucine; Models, Molecular; Prealbumin; Proline; Protein Binding; Protein Structure, Secondary; Thiazoles; X-Ray Diffraction

2000
Renal failure after clinical heart transplantation is associated with the TGF-beta 1 codon 10 gene polymorphism.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2000, Volume: 19, Issue:9

    Topics: Adult; Cyclosporine; Female; Genotype; Heart Transplantation; Humans; Immunosuppressive Agents; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Renal Insufficiency; Sequence Analysis, DNA; Transforming Growth Factor beta

2000
Five novel genetic variants in the promoter and coding region of the alpha B-crystallin gene (CRYAB): -652G>A, -650C>G, -249G>C, S41Y, P51L.
    Human mutation, 2000, Volume: 16, Issue:4

    Topics: Amino Acid Substitution; Crystallins; Exons; Genetic Variation; Humans; Leucine; Mutation, Missense; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Serine; Tyrosine

2000
Metachromatic leukodystrophy: a novel mutation (c237delC) and extension of the haplotype associated with the P426L mutation.
    Human mutation, 2000, Volume: 16, Issue:4

    Topics: Adult; Amino Acid Substitution; Cerebroside-Sulfatase; Haplotypes; Humans; Leucine; Leukodystrophy, Metachromatic; Mutation, Missense; Proline; Sequence Deletion

2000
Comparative sequence analysis identified mutations outside the NSP4 cytotoxic domain of tissue culture-adapted ATCC-Wa strain of human rotavirus and a novel inter-species variable domain in its C-terminus.
    Archives of virology, 2000, Volume: 145, Issue:9

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cattle; Cell Line; Cloning, Molecular; DNA-Directed RNA Polymerases; Genome, Viral; Humans; Isoelectric Point; Leucine; Macaca; Molecular Sequence Data; Mutation; Proline; Rotavirus; Serine; Swine; Viral Nonstructural Proteins

2000
Intestinal transport of monosaccharides and amino acids during postnatal development of mink.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Body Weight; Female; Fructose; Glucose; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Lysine; Male; Methionine; Microvilli; Mink; Monosaccharides; Proline

2000
Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.
    The Journal of biological chemistry, 2001, Mar-09, Volume: 276, Issue:10

    Topics: 1-Carboxyglutamic Acid; Alanine; Animals; Arginine; Cations; Circular Dichroism; Conotoxins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Leucine; Lysine; Magnetic Resonance Spectroscopy; Methionine; Mice; Mollusk Venoms; Peptides; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Temperature

2001
Two new mutations (H106P and L178V) in the protoporphyrinogen oxidase gene in Argentinean patients with variegate porphyria.
    Human mutation, 2000, Volume: 16, Issue:6

    Topics: Amino Acid Substitution; Flavoproteins; Histidine; Humans; Leucine; Mitochondrial Proteins; Mutation, Missense; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphyrias, Hepatic; Proline; Protoporphyrinogen Oxidase; Valine

2000
Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1.
    Blood cells, molecules & diseases, 2000, Volume: 26, Issue:5

    Topics: DNA; Gene Frequency; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Phenotype; Polymorphism, Genetic; Proline; Stroke

2000
Intestinal apical amino acid absorption during development of the pig.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:1

    Topics: Age Factors; Amino Acids; Animals; Animals, Suckling; Aspartic Acid; Female; Intestinal Absorption; Intestine, Small; Leucine; Lysine; Methionine; Organ Size; Pregnancy; Proline; Swine

2001
The destabilization of human GCAP1 by a proline to leucine mutation might cause cone-rod dystrophy.
    Human molecular genetics, 2001, Jan-01, Volume: 10, Issue:1

    Topics: Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Cell Line; Circular Dichroism; Cloning, Molecular; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Escherichia coli; Family Health; Glutamic Acid; Guanylate Cyclase-Activating Proteins; Hot Temperature; Humans; Leucine; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myristic Acids; Phenotype; Proline; Retinitis Pigmentosa; Sequence Homology, Amino Acid; Serine; Temperature

2001
Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies.
    Human mutation, 2001, Volume: 17, Issue:1

    Topics: Amino Acid Substitution; Animals; Arginine; Cysteine; Genetic Variation; Glutamine; Homeodomain Proteins; Humans; Intermediate Filament Proteins; Leucine; Membrane Glycoproteins; Mutation; Nerve Tissue Proteins; Optic Atrophies, Hereditary; Peripherins; Prevalence; Proline; Retinal Degeneration; Retinal Diseases; Retinitis Pigmentosa; Rhodopsin; Trans-Activators; Tyrosine

2001
All-L-Leu-Pro-Leu-Pro: a challenging cyclization.
    Journal of peptide science : an official publication of the European Peptide Society, 2000, Volume: 6, Issue:11

    Topics: Cell Division; Chromatography, High Pressure Liquid; Humans; Leucine; Magnetic Resonance Spectroscopy; Models, Chemical; Peptides; Proline; Spectrometry, Mass, Electrospray Ionization; Temperature; Time Factors; Tumor Cells, Cultured

2000
MODY associated with two novel hepatocyte nuclear factor-1alpha loss-of-function mutations (P112L and Q466X).
    Biochemical and biophysical research communications, 2000, Dec-29, Volume: 279, Issue:3

    Topics: Diabetes Mellitus, Type 2; DNA; DNA Mutational Analysis; DNA-Binding Proteins; Female; Glutamine; HeLa Cells; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Hepatocytes; Humans; Immunohistochemistry; Leucine; Male; Mutagenesis, Site-Directed; Nuclear Proteins; Pedigree; Proline; Transcription Factors; Transcriptional Activation

2000
Different conformations of nascent polypeptides during translocation across the ER membrane.
    BMC cell biology, 2000, Volume: 1

    Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Dogs; Endoplasmic Reticulum; Glycosylation; Intracellular Membranes; Leucine; Membrane Transport Proteins; Microsomes; Molecular Sequence Data; Peptide Mapping; Proline; Protein Conformation; Protein Transport; Ribosomes; Signal Recognition Particle; Valine

2000
Integumental amino acid uptake in a carnivorous predator mollusc (Sepia officinalis, Cephalopoda).
    Tissue & cell, 2000, Volume: 32, Issue:5

    Topics: Alanine; Amino Acids; Animals; Biological Transport; Cations; Immunohistochemistry; Leucine; Lysine; Microscopy, Electron; Microscopy, Fluorescence; Microvilli; Mollusca; Proline; Sodium; Time Factors

2000
Is the P25L a "real" VHL mutation?
    Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology, 2001, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; DNA Mutational Analysis; Female; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Leucine; Ligases; Male; Point Mutation; Polymorphism, Genetic; Proline; Proteins; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein

2001
Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation.
    Journal of leukocyte biology, 2001, Volume: 69, Issue:2

    Topics: Adjuvants, Immunologic; Alanine; Antibodies, Monoclonal; Antigens, CD; CD24 Antigen; CD28 Antigens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Membrane; Cells, Cultured; Epitopes, T-Lymphocyte; Humans; Interleukin-2; Interphase; Leucine; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Glycoproteins; Oligopeptides; Proline; T-Lymphocyte Subsets

2001
Asymmetric synthesis of alpha-branched primary amines on solid support via novel hydrazine resins.
    Organic letters, 2001, Apr-19, Volume: 3, Issue:8

    Topics: Amines; Hydrazines; Leucine; Magnetic Resonance Spectroscopy; Models, Chemical; Peptide Biosynthesis; Proline; Resins, Plant

2001
No leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y in Japanese population or Japanese with alcoholism.
    Psychiatric genetics, 2001, Volume: 11, Issue:1

    Topics: Alcoholism; Amino Acid Substitution; Asian People; DNA; DNA Mutational Analysis; DNA Primers; Gene Amplification; Hospitals, Psychiatric; Humans; Japan; Leucine; Molecular Sequence Data; Neuropeptide Y; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Protein Sorting Signals; Tokyo

2001
A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population.
    Journal of clinical pharmacy and therapeutics, 2001, Volume: 26, Issue:3

    Topics: Adult; Base Sequence; Female; Humans; Japan; Leucine; Male; Middle Aged; Molecular Sequence Data; Neuropeptide Y; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals

2001
The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker.
    Journal of periodontology, 2001, Volume: 72, Issue:6

    Topics: Adult; Age Factors; Alleles; Analysis of Variance; Arginine; Calcium Channel Blockers; Chi-Square Distribution; Codon; Confidence Intervals; Cyclosporine; DNA; Female; Gene Expression Regulation; Genotype; Gingival Overgrowth; Heterozygote; Homozygote; Humans; Immunosuppressive Agents; Kidney Transplantation; Leucine; Logistic Models; Male; Odds Ratio; Polymorphism, Genetic; Proline; Transforming Growth Factor beta; Transforming Growth Factor beta1

2001
Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation.
    Journal of the American Chemical Society, 2001, Aug-22, Volume: 123, Issue:33

    Topics: Alkanes; Amino Acids; Butylamines; Catalysis; Hydroxylation; Isoleucine; Leucine; Molecular Structure; Organoplatinum Compounds; Pentanoic Acids; Proline; Stereoisomerism; Valine; Water

2001
Survivability of biomolecules during extraterrestrial delivery: new results on pyrolysis of amino acids and poly-amino acids.
    Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2001, Volume: 27, Issue:2

    Topics: Amino Acids; beta-Alanine; Extraterrestrial Environment; Gels; Glutamic Acid; Hot Temperature; Leucine; Meteoroids; Phenylalanine; Piperazines; Proline; Pyrrolidonecarboxylic Acid; Silica Gel; Silicon Dioxide; Valine

2001
Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men.
    Atherosclerosis, 2001, Volume: 159, Issue:1

    Topics: Adult; Blood Pressure; Carotid Artery Diseases; Disease Progression; Finland; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Risk Factors

2001
GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.
    Pharmacogenetics, 2001, Volume: 11, Issue:8

    Topics: Adolescent; Adult; Aged; Alleles; Amino Acid Substitution; Arginine; cis-trans-Isomerases; Female; Glutamic Acid; Glutathione Transferase; Glycine; Humans; Leucine; Lysine; Male; Methionine; Middle Aged; Proline; Threonine

2001
Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity.
    Analytical biochemistry, 2001, Nov-15, Volume: 298, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Leucine; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Proline

2001
Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:11

    Topics: Adult; Amino Acids; Animals; Biological Transport, Active; Female; Fetal Growth Retardation; Fetus; Glycine; Humans; Leucine; Phenylalanine; Placenta; Pregnancy; Proline; Sheep

2001
Transport-defective mutations alter the conformation of the energy-coupling motif of an outer membrane transporter.
    Biochemistry, 2001, Nov-20, Volume: 40, Issue:46

    Topics: Amino Acid Motifs; Amino Acid Substitution; Bacterial Outer Membrane Proteins; Bacterial Proteins; Biological Transport; Electron Spin Resonance Spectroscopy; Energy Metabolism; Energy Transfer; Escherichia coli Proteins; Leucine; Membrane Proteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Proline; Protein Conformation; Receptors, Peptide; Spin Labels; Valine; Vitamin B 12

2001
Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants.
    Biochemical and biophysical research communications, 2002, Jan-11, Volume: 290, Issue:1

    Topics: Alanine; Animals; Antioxidants; Brefeldin A; Cell Membrane; Cell Nucleus; CHO Cells; Cricetinae; Cysteine; Immunohistochemistry; Kinetics; Leucine; Masoprocol; Monensin; Mutation; Nocodazole; Palmitic Acid; Palmitic Acids; Peptides; Proline; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pulmonary Surfactants; Recombinant Proteins; Transfection

2002
C-terminal anchoring of a peptide to class II MHC via the P10 residue is compatible with a peptide bulge.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-01, Volume: 168, Issue:3

    Topics: Amino Acid Substitution; Amino Acids; Antigens, CD; Binding, Competitive; Glycine; HLA-DR Antigens; HLA-DRB3 Chains; Humans; Integrin beta3; Leucine; Peptide Fragments; Platelet Membrane Glycoproteins; Proline; Protein Binding; Protein Conformation; Structure-Activity Relationship

2002
Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].
    Peptides, 2002, Volume: 23, Issue:1

    Topics: Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Humans; Leucine; Luciferases; Peptides; Phosphorylation; Proline; Protein Binding; Proto-Oncogene Proteins c-fos; Receptors, Neuropeptide Y; Signal Transduction; Sulfonamides; Thapsigargin; Time Factors; Transfection; Tumor Cells, Cultured

2002
Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease.
    Journal of medical genetics, 2002, Volume: 39, Issue:2

    Topics: Alzheimer Disease; Amino Acid Substitution; Dementia; Genetic Predisposition to Disease; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Mutation; Paraparesis, Spastic; Presenilin-1; Proline

2002
The impact of the leucine 7 to proline 7 polymorphism of the neuropeptide Y gene on postprandial lipemia and on the response of serum total and lipoprotein lipids to a reduced fat diet.
    European journal of clinical nutrition, 2002, Volume: 56, Issue:2

    Topics: Area Under Curve; Diet, Fat-Restricted; Dietary Fats; Female; Genotype; Humans; Leucine; Lipase; Lipids; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Postprandial Period; Proline; Triglycerides

2002
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia.
    Platelets, 2002, Volume: 13, Issue:2

    Topics: Aged; Amino Acid Substitution; DNA Mutational Analysis; Family Health; Fibrinogen; Genetic Variation; Humans; Leucine; Male; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Binding; Protein Subunits; Thrombasthenia

2002
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
    Molecular genetics and metabolism, 2002, Volume: 75, Issue:3

    Topics: Aged; Amino Acid Substitution; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Female; Genotype; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Triglycerides

2002
A novel mutation of the cathepsin C gene in Papillon-Lefèvre syndrome.
    Journal of periodontology, 2002, Volume: 73, Issue:3

    Topics: Adolescent; Aggressive Periodontitis; Amino Acid Substitution; Cathepsin C; Consanguinity; DNA Mutational Analysis; Female; Humans; Leucine; Male; Mutation, Missense; Papillon-Lefevre Disease; Pedigree; Polymerase Chain Reaction; Proline

2002
Effect of multivalency on the performance of enantioselective separation media for chiral HPLC prepared by linking multiple selectors to a porous polymer support via aliphatic dendrons.
    The Journal of organic chemistry, 2002, Apr-05, Volume: 67, Issue:7

    Topics: Alanine; Amino Acids; Catalysis; Chemistry, Organic; Chromatography, High Pressure Liquid; Leucine; Ligands; Molecular Structure; Polymers; Polymethacrylic Acids; Proline; Stereoisomerism; Time Factors

2002
Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils.
    Journal of molecular biology, 2002, Apr-12, Volume: 317, Issue:5

    Topics: Amyloid Neuropathies, Familial; Humans; Leucine; Microscopy, Atomic Force; Microscopy, Electron; Microscopy, Electron, Scanning; Models, Molecular; Molecular Weight; Plaque, Amyloid; Prealbumin; Proline; Protein Binding; Protein Precursors; Protein Structure, Quaternary; Time Factors

2002
In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum.
    Neuroscience, 2002, Volume: 110, Issue:2

    Topics: Animals; Extracellular Space; Leucine; Male; Neostriatum; Neurokinin A; Neurons; Neuropeptides; Peptide Fragments; Proline; Protease Inhibitors; Protein Structure, Tertiary; Rats; Rats, Wistar; Subcellular Fractions; Substance P; Tachykinins; Tritium

2002
Inhibition of hepatic stellate cell collagen synthesis by N-(methylamino)isobutyric acid.
    Biochemical pharmacology, 2002, Feb-15, Volume: 63, Issue:4

    Topics: Actins; Amino Acids; Aminoisobutyric Acids; Animals; Cells, Cultured; Collagen Type I; Gene Expression; Hepatocytes; Leucine; Liver Cirrhosis; Proline; Rats; Respiratory Distress Syndrome

2002
Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.
    Biochemistry, 2002, May-21, Volume: 41, Issue:20

    Topics: Ankyrin Repeat; Aspartic Acid; Circular Dichroism; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Endopeptidase K; Humans; Hydrolysis; Leucine; Melanoma; Mutation; Peptide Fragments; Proline; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Structure-Activity Relationship; Valine

2002
Sequential extracts of human bone show differing collagen synthetic rates.
    Biochemical Society transactions, 2002, Volume: 30, Issue:2

    Topics: Adult; Aged; Animals; Bone and Bones; Collagen; Gas Chromatography-Mass Spectrometry; Humans; Keto Acids; Kinetics; Leucine; Male; Proline; Swine

2002
The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population.
    Journal of clinical pharmacy and therapeutics, 2002, Volume: 27, Issue:3

    Topics: Adult; Base Sequence; Genetics, Population; Genotype; Humans; Korea; Leucine; Neuropeptide Y; Obesity; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals

2002
Familial isolated hyperCKaemia associated with a new mutation in the caveolin-3 (CAV-3) gene.
    Journal of neurology, neurosurgery, and psychiatry, 2002, Volume: 73, Issue:1

    Topics: Adult; Biopsy; Caveolin 3; Caveolins; Creatine Kinase; Female; Heterozygote; Humans; Immunohistochemistry; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Mutation; Proline

2002
[Genetics of blood coagulation in young stroke patients].
    Ideggyogyaszati szemle, 2002, Mar-20, Volume: 55, Issue:3-4

    Topics: Adult; Age of Onset; Blood Coagulation; Blood Coagulation Factors; Blood Donors; Europe; Factor V; Female; Fibrinogen; Humans; Hungary; Leucine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Peptidyl-Dipeptidase A; Platelet Glycoprotein GPIIb-IIIa Complex; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Prothrombin; Risk Factors; Stroke; Surveys and Questionnaires

2002
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.
    Molecular pharmacology, 2002, Volume: 62, Issue:2

    Topics: Amino Acid Sequence; Cells, Cultured; GTP-Binding Proteins; Humans; Leucine; Molecular Sequence Data; Mutation; Phosphoproteins; Proline; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-B; Recombinant Fusion Proteins; RGS Proteins; Sequence Homology, Amino Acid

2002
Recessive inheritance and variable penetrance of slow-channel congenital myasthenic syndromes.
    Neurology, 2002, Jul-23, Volume: 59, Issue:2

    Topics: Adolescent; Adult; Amino Acid Sequence; Case-Control Studies; DNA Mutational Analysis; Electromyography; Genetic Predisposition to Disease; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Myasthenia Gravis; Phenylalanine; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proline; Receptors, Nicotinic

2002
Proteins of axonal transport: investigation of solubility characteristics and behaviour in gel filtration.
    Journal of neurochemistry, 1976, Volume: 27, Issue:5

    Topics: Animals; Axonal Transport; Chromatography, Gel; Chromatography, Ion Exchange; Drug Administration Routes; Electrophoresis, Polyacrylamide Gel; Geniculate Bodies; Leucine; Membrane Proteins; Molecular Weight; Proline; Rabbits; Retinal Ganglion Cells; Solubility; Subcellular Fractions; Superior Colliculi; Tritium

1976
Topological analysis of peripherin/rds and abnormal glycosylation of the pathogenic Pro216-->Leu mutation.
    The Biochemical journal, 2002, Dec-01, Volume: 368, Issue:Pt 2

    Topics: Amino Acid Sequence; Animals; Asparagine; Glycosylation; Intermediate Filament Proteins; Leucine; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis; Nerve Tissue Proteins; Peripherins; Point Mutation; Proline; Recombinant Proteins; Retinal Degeneration

2002
Effects of epidermal growth factor on placental amino acids uptake in pregnant rats.
    The Journal of veterinary medical science, 2002, Volume: 64, Issue:8

    Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Epidermal Growth Factor; Female; Leucine; Microvilli; Placenta; Pregnancy; Proline; Random Allocation; Rats; Rats, Wistar; Sodium; Up-Regulation

2002
Probing Src homology 2 domain ligand interactions by differential line broadening.
    Biochemistry, 2002, Oct-01, Volume: 41, Issue:39

    Topics: Isoleucine; Leucine; Ligands; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylinositol 3-Kinases; Proline; Protein Subunits; Serine; src Homology Domains; Tyrosine

2002
Assessment of enamelysin (MMP-20) selectivity to three peptide bonds on amelogenin sequence.
    Journal of dental research, 2002, Volume: 81, Issue:10

    Topics: Alanine; Amelogenesis; Amelogenin; Amino Acid Sequence; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Dental Enamel; Dental Enamel Proteins; Hydrolysis; Leucine; Matrix Metalloproteinase 20; Matrix Metalloproteinases; Methionine; Peptide Mapping; Proline; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Serine; Statistics as Topic; Substrate Specificity; Swine; Time Factors; Tooth Calcification; Tryptophan

2002
Heterozygous P250L mutation of fibroblast growth factor receptor 3 in a case of isolated craniosynostosis.
    Journal of medical genetics, 2002, Volume: 39, Issue:10

    Topics: Amino Acid Substitution; Child, Preschool; Cranial Sutures; Craniosynostoses; Exons; Female; Fibroblast Growth Factors; Genetic Carrier Screening; Humans; Leucine; Mutation; Proline; Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Fibroblast Growth Factor

2002
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Oct-15, Volume: 169, Issue:8

    Topics: Adenosine Triphosphate; Alleles; Amino Acid Substitution; Animals; Calcium; Cell Line; Cytoplasm; Humans; Immunity, Innate; Leucine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mutation; Phosphatidylserines; Proline; Protein Structure, Tertiary; Receptors, Purinergic P2; Receptors, Purinergic P2X7; T-Lymphocyte Subsets

2002
Follicle-stimulating hormone interacts with exoloop 3 of the receptor.
    The Journal of biological chemistry, 2002, Dec-20, Volume: 277, Issue:51

    Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cyclic AMP; DNA Mutational Analysis; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Humans; Inositol Phosphates; Kinetics; Leucine; Lysine; Models, Molecular; Molecular Sequence Data; Proline; Protein Binding; Protein Structure, Tertiary; Receptors, FSH; Signal Transduction; Software

2002
Interleukin 4 co-stimulates the PDGF-BB- and bFGF-mediated proliferation of mesangial cells and myofibroblasts.
    Nephron, 2002, Volume: 92, Issue:4

    Topics: Animals; Becaplermin; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Fibroblast Growth Factor 2; Fibroblasts; Fibrosis; Glomerular Mesangium; Humans; Interleukin-4; Kidney Tubules; Leucine; Platelet-Derived Growth Factor; Proline; Proto-Oncogene Proteins c-sis

2002
Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro.
    The American journal of pathology, 2002, Volume: 161, Issue:5

    Topics: Amyloid; Amyloid Neuropathies, Familial; Amyloidosis; Animals; Coloring Agents; Congo Red; Genetic Vectors; Humans; Immunohistochemistry; Intestine, Small; Leucine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Immunoelectron; Mutation; Oxidative Stress; Prealbumin; Proline; RNA, Messenger; Skin

2002
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis.
    Biochemistry, 2002, Dec-03, Volume: 41, Issue:48

    Topics: Amino Acids; Anions; Asparagine; Glutamic Acid; Halogens; Histidine; Hydrolases; Isoleucine; Leucine; Mathematical Computing; Models, Chemical; Mutagenesis, Site-Directed; Phenylalanine; Proline; Quantum Theory; Static Electricity; Tryptophan; Valine

2002
Hb Manawatu [alpha 37(C2)Pro-->Leu]: a new mildly unstable mutation at an invariant proline residue.
    Hemoglobin, 2002, Volume: 26, Issue:4

    Topics: Adult; Amino Acid Substitution; Female; Genetic Variation; Hemoglobins, Abnormal; Humans; Leucine; Molecular Weight; Mutation; Proline; United Kingdom

2002
Conserved proline residue at position 189 in cone visual pigments as a determinant of molecular properties different from rhodopsins.
    Biochemistry, 2002, Dec-24, Volume: 41, Issue:51

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Avian Proteins; Cell Line; Chickens; Conserved Sequence; Epitopes; Eye Proteins; Genetic Vectors; Glycine; Humans; Isoleucine; Leucine; Mice; Proline; Retinal Cone Photoreceptor Cells; Retinal Pigments; Rhodopsin; Serine; Spectrophotometry; Thermodynamics; Valine

2002
Plastocyanin-cytochrome f interactions: the influence of hydrophobic patch mutations studied by NMR spectroscopy.
    Biochemistry, 2002, Dec-31, Volume: 41, Issue:52

    Topics: Binding Sites; Conserved Sequence; Cyanobacteria; Cytochromes; Cytochromes f; Glycine; Histidine; Hydrophobic and Hydrophilic Interactions; Leucine; Macromolecular Substances; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Plastocyanin; Prochlorothrix; Proline; Protons; Tyrosine

2002
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
    Journal of medical genetics, 2003, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Amino Acid Substitution; Cell Extracts; Cell Line; Child; Chromosomes, Human, X; Coenzyme A Ligases; Female; Genetic Carrier Screening; Genetic Testing; Humans; Infant; Leucine; Lymphocytes; Male; Mental Retardation, X-Linked; Middle Aged; Molecular Diagnostic Techniques; Mutation, Missense; Pedigree; Proline; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sex Chromosome Aberrations

2003
Early and persistent sensory-psychiatric symptoms in an inherited prion disease with a PrP P105L mutation.
    Journal of neurology, 2002, Volume: 249, Issue:12

    Topics: Female; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Prion Diseases; Prions; Proline

2002
Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease.
    The Journal of investigative dermatology, 2003, Volume: 120, Issue:2

    Topics: Adolescent; Alleles; Amino Acid Substitution; Animals; Calcium; Calcium-Transporting ATPases; COS Cells; Darier Disease; Family Health; Humans; Leucine; Male; Pedigree; Point Mutation; Proline; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2003
Impairment of signal transduction in response to stimulation of the naturally occurring Pro279Leu variant of the h5-HT7(a) receptor.
    Pharmacogenetics, 2003, Volume: 13, Issue:2

    Topics: Binding, Competitive; Cell Membrane; Cells, Cultured; Cyclic AMP; Humans; Kidney; Leucine; Ligands; Proline; Protein Binding; Radioligand Assay; Receptors, Serotonin; Second Messenger Systems; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction

2003
Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene.
    Neuromuscular disorders : NMD, 2003, Volume: 13, Issue:2

    Topics: Adenine Nucleotide Translocator 1; Adult; Biopsy; Bipolar Disorder; Blotting, Western; Electron Transport Complex IV; Female; Genes, Dominant; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Leucine; Molecular Sequence Data; Muscle, Skeletal; Mutation, Missense; Myosins; Ophthalmoplegia; Pedigree; Proline

2003
Novel mutant human fibronectin FIII9-10 domain pair with increased conformational stability and biological activity.
    Protein engineering, 2002, Volume: 15, Issue:12

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Adhesion; Cells, Cultured; Escherichia coli; Fibronectins; Humans; Leucine; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Proline; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Solubility

2002
No association between the TGF-beta 1 Leu10Pro polymorphism and osteoporosis among white women in the United States.
    The American journal of medicine, 2003, Feb-15, Volume: 114, Issue:3

    Topics: Aged; Amino Acid Sequence; Bone Density; Cohort Studies; Female; Fractures, Bone; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Multivariate Analysis; Osteoporosis; Polymorphism, Genetic; Proline; Proportional Hazards Models; Risk Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; United States; White People

2003
[Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].
    Medicina clinica, 2003, Mar-15, Volume: 120, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Female; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Prevalence; Proline; Protein Precursors; Spain

2003
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein.
    The Biochemical journal, 2003, Jul-01, Volume: 373, Issue:Pt 1

    Topics: Amino Acid Sequence; Binding Sites; Catalysis; Chromosomes, Human, X; Endopeptidases; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glycine; Humans; Hypophosphatemia; Kinetics; Leucine; Molecular Sequence Data; Oligopeptides; Peptide Fragments; PHEX Phosphate Regulating Neutral Endopeptidase; Proline; Proteins; Recombinant Proteins; Substrate Specificity

2003
Neuropathological features of a case with schizophrenia and prion protein gene P102L mutation before onset of Gerstmann-Sträussler-Scheinker disease.
    Acta neuropathologica, 2003, Volume: 106, Issue:1

    Topics: Amyloid beta-Peptides; Astrocytes; Brain; Family Health; Female; Gerstmann-Straussler-Scheinker Disease; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Inclusion Bodies; Leucine; Microscopy, Electron; Middle Aged; Mutation; Organ Size; Pedigree; Prions; Proline; S100 Proteins; Schizophrenia; Staining and Labeling; Ubiquitin

2003
Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro).
    Thrombosis research, 2003, Jan-25, Volume: 109, Issue:2-3

    Topics: Child, Preschool; Fibrinogens, Abnormal; Fibrinopeptide A; Humans; Leucine; Male; Mutation; Proline; Thrombin; Thrombin Time

2003
4'-iodo-4'-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:8

    Topics: Amino Acid Substitution; Amyloid; Animals; Caspase 3; Caspases; Cell Survival; Doxorubicin; Doxycycline; Drug Evaluation, Preclinical; Enzyme Activation; Leucine; Microscopy, Electron; Mutation; Nitrophenols; Prealbumin; Proline; Rolitetracycline; Tetracyclines; Tumor Cells, Cultured

2003
A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer.
    Cancer research, 2003, May-15, Volume: 63, Issue:10

    Topics: Amino Acid Substitution; Breast Neoplasms; Case-Control Studies; HeLa Cells; Humans; Leucine; Neoplasm Invasiveness; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Proline; Promoter Regions, Genetic; Protein Sorting Signals; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1

2003
Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.
    Protein science : a publication of the Protein Society, 2003, Volume: 12, Issue:6

    Topics: Amyloid; Computer Simulation; Humans; Hydrogen Bonding; Leucine; Models, Molecular; Point Mutation; Prealbumin; Proline; Protein Conformation; Protein Folding; Recombinant Proteins; Structure-Activity Relationship

2003
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF.
    The Journal of biological chemistry, 2003, Aug-29, Volume: 278, Issue:35

    Topics: Animals; Arthritis, Rheumatoid; Asparagine; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocytes; Cell Membrane; Cell Separation; Cell Survival; CHO Cells; Cricetinae; Dimerization; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin G; Leucine; Lupus Erythematosus, Systemic; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Proline; Protein Binding; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Spleen; Tumor Necrosis Factor-alpha; Valine

2003
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
    Cancer research, 2003, Jun-15, Volume: 63, Issue:12

    Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; Enzyme Induction; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Leucine; Loss of Heterozygosity; Neoplasm Proteins; Polymorphism, Genetic; Proline; Recombinant Fusion Proteins; Repetitive Sequences, Amino Acid; Selenium; Structure-Activity Relationship; Tumor Cells, Cultured

2003
Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y.
    Atherosclerosis, 2003, Volume: 167, Issue:2

    Topics: Adult; Age Factors; Aged; Analysis of Variance; Blood Pressure Determination; Brachial Artery; Child; Coronary Disease; Endothelium, Vascular; Female; Genetic Predisposition to Disease; Humans; Hypercholesterolemia; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Probability; Proline; Prospective Studies; Protein Sorting Signals; Reference Values; Risk Factors; Sampling Studies; Statistics, Nonparametric; Vasodilation

2003
A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases.
    International journal of molecular medicine, 2003, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Amino Acid Substitution; Asthma; Case-Control Studies; Cells, Cultured; Child; Dermatitis, Atopic; DNA-Binding Proteins; Female; Genetic Linkage; Genetic Predisposition to Disease; Humans; Hypersensitivity; Immunoglobulin E; Interferon gamma Receptor; Interferon-gamma; Interleukin-12; Interleukin-18; Leucine; Male; Neutrophils; Pedigree; Phosphorylation; Point Mutation; Proline; Receptors, Interferon; Rhinitis, Allergic, Perennial; STAT1 Transcription Factor; Trans-Activators

2003
Targeting and assembly of mitochondrial tail-anchored protein Tom5 to the TOM complex depend on a signal distinct from that of tail-anchored proteins dispersed in the membrane.
    The Journal of biological chemistry, 2003, Oct-17, Volume: 278, Issue:42

    Topics: Alanine; Amino Acid Sequence; Animals; Carrier Proteins; Cell Membrane; COS Cells; DNA; Electrophoresis, Polyacrylamide Gel; Green Fluorescent Proteins; Leucine; Luminescent Proteins; Membrane Proteins; Microscopy, Fluorescence; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Molecular Sequence Data; Phenotype; Plasmids; Proline; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Subcellular Fractions; Temperature

2003
Integrin beta3 Leu33Pro homozygosity and risk of cancer.
    Journal of the National Cancer Institute, 2003, Aug-06, Volume: 95, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Animals; Cytosine; Denmark; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Integrin beta3; Leucine; Male; Middle Aged; Neoplasm Invasiveness; Neoplasms; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment; Risk Factors; Thymine

2003
Leucine 7 to proline 7 polymorphism of the preproneuropeptide Y gene is not associated with restenosis after coronary stenting.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2003, Volume: 10, Issue:3

    Topics: Coronary Restenosis; Humans; Leucine; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Stents

2003
Amino acid composition and electrophoretic properties of hypertensin I.
    The Journal of experimental medicine, 1955, Oct-01, Volume: 102, Issue:4

    Topics: Amino Acids; Angiotensin Amide; Angiotensins; Arginine; Aspartic Acid; Glycine; Histidine; Isoleucine; Leucine; Phenylalanine; Proline; Serine; Tyrosine; Valine

1955
The nutrition of animal tissues cultivated in vitro. IV. Amino acid requirements of chick embryonic heart fibroblasts.
    The Journal of biophysical and biochemical cytology, 1957, Mar-25, Volume: 3, Issue:2

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chickens; Cystine; Fibroblasts; Glycine; Histidine; Hydroxyproline; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tissue Culture Techniques; Tryptophan; Tyrosine; Valine

1957
alpha-Aminoisobutyric acid, beta-hydroxyleucine, and gamma-methylproline from the hydrolysis of a natural product.
    Nature, 1958, Jan-04, Volume: 181, Issue:4601

    Topics: Amino Acids; Aminoisobutyric Acids; Anti-Bacterial Agents; Antibiotics, Antitubercular; Biological Products; Hydrolysis; Leucine; Proline

1958
Studies on the metabolism of valine, proline, leucine and isoleucine by rumen microorganisms in vitro.
    Archives of biochemistry and biophysics, 1958, Volume: 78, Issue:1

    Topics: Animals; Biochemical Phenomena; Humans; In Vitro Techniques; Isoleucine; Leucine; Proline; Rumen; Stomach; Valine

1958
Amino acid dependent control of DNA synthesis in bacteria and vegetative phage.
    Proceedings of the National Academy of Sciences of the United States of America, 1962, Oct-15, Volume: 48

    Topics: Amino Acids; Arginine; Coliphages; Cysteine; DNA; DNA, Bacterial; Escherichia coli; Histidine; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan

1962
EFFECTS OF CERTAIN AMINO ACIDS ON ANTHRANILATE PRODUCTION IN NEUROSPORA CRASSA.
    Journal of bacteriology, 1963, Volume: 85

    Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography; Fluorescence; Leucine; Metabolism; Methionine; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Phenylalanine; Proline; Tryptophan; Tyrosine

1963
GAS CHROMATOGRAPHY OF THE METHYL ESTERS OF THE AMINO ACIDS AS THE FREE BASE AND BY DISSOCIATION OF THEIR ACID SALTS.
    Journal of chromatography, 1963, Volume: 11

    Topics: Acetates; Amino Acids; Aspartic Acid; Chlorides; Chromatography; Chromatography, Gas; Cysteine; Cystine; Esters; Hydroxyproline; Ion Exchange Resins; Leucine; Lysine; Phenylalanine; Proline; Research; Salts; Serine

1963
GENE TRANSFER BY F' STRAINS OF ESCHERICHIA COLI K-12. II. INTERACTION BETWEEN F-MEROGENOTE AND CHROMOSOME DURING TRANSFER.
    Journal of bacteriology, 1963, Volume: 85

    Topics: Chromosomes; Escherichia coli; Escherichia coli K12; Galactose; Histidine; Isoleucine; Lactose; Leucine; Maltose; Mannitol; Methionine; Proline; Research; Serine; Streptomycin; Thiamine; Threonine; Tryptophan; Valine; Xylose

1963
AMINO ACID FORMATION FROM GLUCOSE IN THE ISOLATED ADRENOCORTICAL AND THYROID TISSUE OF THE RABBIT.
    Acta endocrinologica, 1963, Volume: 44

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Alanine; Arginine; Aspartic Acid; Chromatography; Glucose; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Pharmacology; Proline; Proteins; Rabbits; Research; Thyroid Gland; Thyrotropin

1963
SPECIFICITY OF PEPSIN AND ITS DEPENDENCE ON A POSSIBLE 'HYDROPHOBICBINDING SITE'.
    Nature, 1963, Sep-14, Volume: 199

    Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pepsin A; Peptides; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine; Valine

1963
GAS CHROMATOGRAPHY OF AMINO ACIDS. 1. ANALYSIS OF THE MIXTURE OF METHYL-NTRIFLUOROACETYL DERIVATIVES.
    Journal of biochemistry, 1963, Volume: 54

    Topics: Alanine; Amino Acids; Aspartic Acid; Chromatography; Chromatography, Gas; Fluoroacetates; Glutamates; Glycine; Hydroxyproline; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine

1963
AMINO-ACID CONFIGURATION OF MYCOBACILLIN.
    Nature, 1963, Nov-02, Volume: 200

    Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Antifungal Agents; Aspartic Acid; Chemistry Techniques, Analytical; Glutamates; Leucine; Mycobacillin; Proline; Research; Serine; Tyrosine

1963
PEPITASE ACTIVITIES IN TISSUES OF TUMOR-BEARING RATS.
    Cancer research, 1963, Volume: 23

    Topics: Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Erythrocytes; Glycine; Leucine; Liver; Liver Neoplasms; Muscles; Neoplasms; Neoplasms, Experimental; Peptide Hydrolases; Peptides; Proline; Rats; Research; Sarcoma; Sarcoma, Experimental

1963
BACTERIAL POLYRIBOSOMES AND THEIR PARTICIPATION IN PROTEIN SYNTHESIS IN VIVO.
    Journal of molecular biology, 1963, Volume: 7

    Topics: Bacillus megaterium; Bacterial Proteins; Centrifugation; Leucine; Lysine; Nucleoproteins; Polyribosomes; Proline; Protein Biosynthesis; Proteins; Research; Salmonella typhimurium; Tritium

1963
ORIGIN OF PROTOTROPHIC VARIANTS IN MIXTURES OF AUXOTROPHIC MUTANTS OF SERRATIA MARCESCENS.
    Journal of bacteriology, 1963, Volume: 86

    Topics: Adenine; Isoleucine; Leucine; Massachusetts; Mutation; Proline; Research; Serine; Serratia marcescens; Streptomycin; Thiamine; Tryptophan; Ultraviolet Rays

1963
THE INHIBITION OF CEREBRAL DIGLYCINASE BY ALPHA-AMINO-, ALPHA-KETO- AND ALPHA-HYDROXY ACIDS.
    Journal of neurochemistry, 1963, Volume: 10

    Topics: Alanine; Aminobutyrates; Animals; Arginine; Aspartic Acid; Brain; Cobalt; Enzyme Inhibitors; Histidine; Hydroxy Acids; Keto Acids; Leucine; Methionine; Mice; Peptide Hydrolases; Peptides; Pharmacology; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Valine

1963
OXIDATION OF L-AMINO ACIDS AND INCORPORATION INTO PROTEIN IN HOMOGENATES OF BRAIN AT TWO STAGES OF DEVELOPMENT.
    Journal of neurochemistry, 1963, Volume: 10

    Topics: Alanine; Amino Acids; Arginine; Autoradiography; Brain; Carbon Isotopes; Chromatography; Glycine; Histidine; Isoleucine; Keto Acids; Leucine; Lysine; Mice; Nerve Tissue Proteins; Phenylalanine; Proline; Proteins; Pyruvates; Research; Serine; Threonine; Valine

1963
[ON THE QUANTITATIVE DETERMINATION OF AMINO ACIDS USING HIGH VOLTAGE ELECTROPHORESIS].
    Biochemische Zeitschrift, 1963, Sep-19, Volume: 339

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Blood Protein Electrophoresis; Glutamates; Histidine; Leucine; Lysine; Methionine; Ornithine; Proline; Research; Serine; Threonine; Tyrosine; Valine

1963
[INCORPORATION OF LABELLED AMINO ACIDS INTO ACELLULAR FRACTIONS OF RABBIT AORTIC TISSUE].
    Bulletin de la Societe de chimie biologique, 1963, Volume: 45

    Topics: Adenosine Triphosphate; Amino Acids; Aorta; Carbon Isotopes; Glycine; Leucine; Liver; Proline; Proteins; Rabbits; Research; RNA; Spectrophotometry; Tissue Extracts

1963
STUDIES IN EXPERIMENTAL LATHYRISM. III. EFFECT OF LATHYRISM ON THE IMINO ACIDS OF CHICK EMBRYOS.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Animals; Carbon Isotopes; Chick Embryo; Collagen; Cyanides; Glutamates; Hydroxyproline; Imines; Imino Acids; Lathyrism; Leucine; Nitrogen; Proline; Proteins; Radioisotopes; Research; Toxicology

1964
BIOCHEMISTRY OF LUNGS IN RELATION TO SILICOSIS. II. THE EFFECT OF QUARTZ DUST ON THE PROTEIN AMINO ACIDS OF GUINEA PIG LUNG TISSUE.
    Archives of environmental health, 1964, Volume: 8

    Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Collagen; Cystine; Dust; Glutamates; Glycine; Guinea Pigs; Histidine; Hydroxyproline; Isoleucine; Leucine; Lung; Lysine; Methionine; Phenylalanine; Proline; Quartz; Research; Serine; Silicon Dioxide; Silicosis; Threonine; Toxicology; Tyrosine; Valine

1964
A DETERMINATION OF THE ESSENTIAL AMINO ACID PROPORTIONS NEEDED TO ALLOW RAPID GROWTH IN CHICKS.
    The Journal of nutrition, 1964, Volume: 82, Issue:1

    Topics: Amino Acids; Amino Acids, Essential; Animals; Animals, Newborn; Arginine; Caseins; Chickens; Cystine; Diet; Dietary Proteins; Glutamates; Growth; Histidine; Isoleucine; Leucine; Lysine; Methionine; Nitrogen; Phenylalanine; Poultry; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine

1964
CELL-FREE PROTEIN SYNTHESIS: THE NATURE OF THE ACTIVE COMPLEX.
    Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 51

    Topics: Bacterial Proteins; Carbon Isotopes; Cytoplasm; Escherichia coli; Leucine; Phenylalanine; Phosphorus Isotopes; Plant Viruses; Proline; Protein Biosynthesis; Proteins; Research; Ribosomes; RNA; RNA, Bacterial; RNA, Viral; Tritium

1964
EFFECT OF AMINO ACIDS ON UPTAKE OF L-HISTIDINE BY RAT BRAIN SLICES.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Amino Acids; Arginine; Brain; Chromatography; Culture Media; Cysteine; Cystine; Dipeptides; Glutamates; Histidine; Hydroxyproline; Isoleucine; Leucine; Metabolism; Phenylalanine; Pimelic Acids; Proline; Rats; Research; Taurine; Tryptophan; Valine

1964
EFFECT OF SPORULATION MEDIUM ON HEAT RESISTANCE, CHEMICAL COMPOSITION, AND GERMINATION OF BACILLUS MEGATERIUM SPORES.
    Journal of bacteriology, 1964, Volume: 87

    Topics: Alanine; Bacillus megaterium; Bacteriological Techniques; Biochemical Phenomena; Biochemistry; Culture Media; Glucose; Glutamates; Glutamic Acid; Hot Temperature; Leucine; Nitrates; Phosphates; Picolinic Acids; Potassium; Proline; Research; Spores; Spores, Bacterial

1964
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
    The Nebraska state medical journal, 1964, Volume: 49

    Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine

1964
CENTRIFUGAL PAPER CHROMATOGRAPHY AND SOME OF ITS APPLICATIONS.
    Journal of chromatography, 1964, Volume: 13

    Topics: Anthelmintics; Chromatography; Chromatography, Paper; Fumarates; Histidine; Leucine; Malates; Maleates; Organophosphate Poisoning; Phosphorus; Poisons; Proline; Research; Tetracycline; Triamcinolone; Urea

1964
POLYNUCLEOTIDE ANALOGUES. II. STIMULATION OF AMINO ACID INCORPORATION BY POLYNUCLEOTIDE ANALOGUES.
    Biochimica et biophysica acta, 1964, Mar-23, Volume: 80

    Topics: Amino Acids; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Glycine; Isoleucine; Leucine; Lysine; Pharmacology; Phenylalanine; Polynucleotides; Proline; Proteins; Research; Serine; Threonine; Tryptophan; Tyrosine; Uracil Nucleotides; Valine

1964
DYNAMIC PHENOMENA IN MICROSPHERES FROM THERMAL PROTEINOID.
    Comparative biochemistry and physiology, 1964, Volume: 11

    Topics: Alanine; Arginine; Aspartic Acid; Colloids; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Microspheres; Peptides; Phenylalanine; Photomicrography; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine

1964
[SEPARATION OF AMINO ACIDS BY CHROMATOGRAPHY ON THIN LAYERS OF DIETHYLAMINOETHYL CELLULOSE].
    Journal of chromatography, 1964, Volume: 13

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cellulose; Chromatography; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine

1964
THE TRANSFER SYSTEM FOR NEUTRAL AMINO ACIDS IN THE RAT SMALL INTESTINE.
    The Journal of physiology, 1964, Volume: 170

    Topics: Amino Acids, Neutral; Ammonium Compounds; Glycine; Intestine, Small; Intestines; Leucine; Methionine; Proline; Proteins; Quaternary Ammonium Compounds; Rats; Research

1964
PLASMA AMINO ACID PATTERNS IN ALCOHOLISM: THE EFFECTS OF ETHANOL LOADING.
    Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 51

    Topics: Alanine; Alcoholism; Amino Acids; Autoanalysis; Biomedical Research; Blood; Ethanol; Genetics, Medical; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Methionine; NAD; NADP; Proline; Proteins; Serine; Toxicology; Valine

1964
INFLUENCE OF BETA-AMINOPROPIONITRILE ON DISSECTING ANEURYSM AND ON PLASMA AMINO ACIDS IN THE TURKEY.
    Metabolism: clinical and experimental, 1964, Volume: 13

    Topics: Alanine; Amino Acids; Aminopropionitrile; Ammonia; Aneurysm; Animals; Aortic Dissection; Arginine; Autoanalysis; Blood; Chromatography; Collagen; Cyanides; Diet; Histidine; Isoleucine; Leucine; Lysine; Pharmacology; Poultry; Proline; Proteins; Research; Turkey; Valine

1964
STUDIES ON THE HYDROLYTIC ACTION OF PRONASE ON DERIVATIZED AND NON-DERIVATIZED PROTEINS.
    Biochimica et biophysica acta, 1964, Jun-01, Volume: 85

    Topics: Alanine; Arginine; Asparagine; Cystine; Dinitrophenols; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Peptide Hydrolases; Phenylalanine; Proline; Pronase; Proteins; Research; Ribonucleases; Streptomyces; Threonine; Tyrosine; Valine

1964
INACTIVATION OF SOLUBLE RIBONUCLEIC ACID BY ELECTRON IRRADIATION.
    Radiation research, 1964, Volume: 22

    Topics: Alanine; Amino Acids; Carbon Isotopes; Electrons; Isoleucine; Leucine; Liver; Methionine; Proline; Radiation Effects; Rats; Research; RNA; Saccharomyces; Tritium; Valine

1964
MYOGLOBIN FREE-RADICALS.
    Biochimica et biophysica acta, 1964, Jul-29, Volume: 88

    Topics: Alanine; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Glycine; Histidine; Hydrogen Peroxide; Leucine; Myoglobin; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine

1964
DIFFERENTIAL MUTATION PRODUCTION BY THE DECAY OF INCORPORATED TRITIUM COMPOUNDS IN E. COLI.
    Biophysical journal, 1964, Volume: 4

    Topics: Arginine; DNA; DNA, Bacterial; Escherichia coli; Histidine; Leucine; Mutation; Nucleosides; Proline; RNA; RNA, Bacterial; Thymidine; Tritium; Uracil; Uridine

1964
CLEAVAGE OF PEPTIDE PROLINE BONDS BY LITHIUM ALUMINUM HYDRIDE.
    Biochemistry, 1964, Volume: 3

    Topics: Aluminum Compounds; Amides; Amino Alcohols; Ammonia; Aspartic Acid; Autoanalysis; Chromatography; Countercurrent Distribution; Glutamates; Glycine; Indicators and Reagents; Leucine; Lithium Compounds; Ornithine; Peptides; Phenylalanine; Proline; Research; Tryptophan; Tyrothricin

1964
STUDIES ON THE BIOLOGICAL ACTIVITY OF RIBONUCLEIC ACID ISOLATED FROM ESCHERICHIA COLI AFTER EXPOSURE TO 5-FLUOROURACIL.
    Biochimica et biophysica acta, 1964, Jul-22, Volume: 87

    Topics: Arginine; Escherichia coli; Fluorouracil; Leucine; Metabolism; Pharmacology; Proline; Proteins; Research; RNA; RNA, Bacterial; Serine; Spectrophotometry

1964
GEL FILTRATION PROPERTIES OF CCD-PREPARED E. COLI B SRNA.
    Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 52

    Topics: Alanine; Chromatography; Chromatography, Gel; Countercurrent Distribution; Escherichia coli; Leucine; Proline; Research; RNA; RNA, Bacterial

1964
CLUSTERING OF FUNCTIONALLY RELATED GENES IN SALMONELLA TYPHIMURIUM.
    Proceedings of the National Academy of Sciences of the United States of America, 1964, Volume: 51

    Topics: Arginine; Cysteine; Escherichia coli; Glycine; Guanine; Histidine; Isoleucine; Leucine; Metabolism; Methionine; Molecular Biology; Mutation; Pantothenic Acid; Proline; Purines; Pyrimidines; Research; Salmonella typhimurium; Serine; Threonine; Tryptophan

1964
AMINO ACIDS AS PROTECTIVE COMPOUNDS IN ULTRAVIOLET-IRRADIATED HANSENULA WINGEI.
    Journal of bacteriology, 1964, Volume: 88

    Topics: Alanine; Amino Acids; Arginine; Cysteine; Cystine; Ethionine; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Pichia; Proline; Radiation-Protective Agents; Research; Serine; Threonine; Tryptophan; Tyrosine; Ultraviolet Rays; Valine; Yeasts

1964
STUDIES ON THE MECHANISM OF METHYLCHOLANTHRENE INDUCTION OF ENZYME ACTIVITIES OF RAT LIVER. I. AMINO ACID INCORPORATION IN RAT-LIVER HOMOGENATES.
    Biochimica et biophysica acta, 1964, Sep-11, Volume: 91

    Topics: Amino Acids; Leucine; Liver; Magnesium; Methylcholanthrene; Microsomes; Mitochondria; Phenylalanine; Proline; Rats; Research; Valine

1964
INHIBITION OF ADP-INDUCED PLATELET AGGREGATION BY SUBSTITUTED AMINO-ACIDS.
    Nature, 1964, Nov-14, Volume: 204

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Alanine; Alkylation; Amino Acids; Aminocaproates; Aminocaproic Acid; Arginine; Blood Platelets; Butyrates; Glutamine; Glycine; Guanidines; Leucine; Pharmacology; Phenylalanine; Platelet Aggregation; Proline; Research; Thrombosis; Tyrosine

1964
RNA CODEWORDS AND PROTEIN SYNTHESIS. THE NUCLEOTIDE SEQUENCES OF MULTIPLE CODEWORDS FOR PHENYLALANINE, SERINE, LEUCINE, AND PROLINE.
    Science (New York, N.Y.), 1965, Jan-29, Volume: 147, Issue:3657

    Topics: Base Sequence; Carbon Isotopes; Chromatography; Electrophoresis; Escherichia coli; Genetic Code; Leucine; Nucleotides; Phenylalanine; Proline; Protein Biosynthesis; Proteins; Research; Ribosomes; RNA; RNA, Bacterial; Serine

1965
GENETIC CONTROL OF RESTRICTION AND MODIFICATION IN ESCHERICHIA COLI.
    Journal of bacteriology, 1964, Volume: 88

    Topics: Amino Acids; Arabinose; Arginine; Chromosomes; Coliphages; Cysteine; DNA; DNA, Bacterial; Drug Resistance; Drug Resistance, Microbial; Escherichia coli; Galactose; Genetics; Hot Temperature; Lactose; Leucine; Methionine; Proline; Research; Salmonella typhi; Streptomycin; Thiamine; Threonine; Tryptophan

1964
LETHAL EFFECT OF L-LEUCINE ON E. COLI, IN VIVO CORROBORATION OF CODING AMBIGUITY.
    Biochemical and biophysical research communications, 1965, Feb-03, Volume: 18

    Topics: Culture Media; Escherichia coli; Genetic Code; Histidine; Isoleucine; Leucine; Molecular Biology; Mutation; Phenylalanine; Polynucleotides; Proline; Proteins; Research; Uracil Nucleotides

1965
RAT LIVER ENZYME DOES NOT ACTIVATE ACETYLAMINO ACIDS.
    Journal of biochemistry, 1965, Volume: 57

    Topics: Acetates; Adenosine Triphosphate; Alanine; Amino Acids; Arginine; Diphosphates; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Liver; Lysine; Methionine; Phenylalanine; Proline; Rats; Research; RNA; Serine; Threonine; Tryptophan; Tyrosine; Valine

1965
RESOLUTION OF AMINO ACIDS BY GAS CHROMATOGRAPHY.
    Journal of chromatography, 1965, Volume: 17

    Topics: Alanine; Alcohols; Amino Acids; Chromatography; Chromatography, Gas; Glutamates; Leucine; Phenylalanine; Proline; Research; Valine

1965
EFFECT OF AMINO ACIDS ON GROWTH OF SPHAEROTILUS DISCOPHORUS.
    Antonie van Leeuwenhoek, 1965, Volume: 31

    Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Bacteriological Techniques; Caseins; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Proline; Research; Serine; Sphaerotilus; Threonine; Tryptophan; Tyrosine; Valine

1965
HIGH SENSITIVITY OPTICAL RESOLUTION OF D,L AMINO ACIDS BY GAS CHROMATOGRAPHY.
    Biochemical and biophysical research communications, 1965, Apr-23, Volume: 19

    Topics: Alanine; Amino Acids; Chromatography; Chromatography, Gas; Leucine; Methionine; Phenylalanine; Proline; Research; Tyrothricin; Valine

1965
GAS CHROMATOGRAPHY OF VOLATILE AMINO ACID DERIVATIVES. II. LEUCINE, CYSTEINE, PROLINE, HYDROXYPROLINE, METHIONINE, PHENYLALANINE, ASPARTIC ACID AND GLUTAMIC ACID.
    Journal of chromatography, 1965, Volume: 17

    Topics: Arginine; Aspartic Acid; Chromatography; Chromatography, Gas; Cysteine; Glutamates; Glutamic Acid; Hydroxyproline; Leucine; Methionine; Phenylalanine; Proline; Research

1965
DECREASE IN APPETITE AND BIOCHEMICAL CHANGES IN AMINO ACID IMBALANCE IN THE RAT.
    The Journal of nutrition, 1965, Volume: 86, Issue:4

    Topics: Alanine; Amino Acids; Appetite; Biochemical Phenomena; Biochemistry; Diet; Dietary Proteins; Glutamates; Glutens; Isoleucine; Kwashiorkor; Leucine; Liver; Lysine; Muscles; Proline; Rats; Research; Serine; Threonine; Valine

1965
NUCLEIC ACIDS AND PROTEIN SYNTHESIS OF ISOLATED CELLS FROM CHICK EMBRYONIC SPINAL GANGLIA IN CULTURE.
    The Journal of experimental zoology, 1965, Volume: 158

    Topics: Amino Acids; Animals; Autoradiography; Cell Biology; Chick Embryo; DNA; Ganglia, Spinal; Leucine; Lysine; Metabolism; Neuroglia; Neurons; Nucleic Acids; Phenylalanine; Proline; Regeneration; Research; RNA; Thymidine; Tissue Culture Techniques; Tritium; Uridine

1965
SOURCE OF COLLAGEN AT EPITHELIOMESENCHYMAL INTERFACES DURING INDUCTIVE INTERACTION.
    Developmental biology, 1965, Volume: 11

    Topics: Autoradiography; Collagen; Embryology; Endopeptidases; Epithelium; Glycine; Hyaluronoglucosaminidase; Leucine; Mice; Photomicrography; Proline; Research; Salivary Glands; Tissue Culture Techniques; Tritium

1965
BITTER PEPTIDE ISOLATED FROM MILK CULTURES OF STREPTOCOCCUS CREMORIS.
    Applied microbiology, 1965, Volume: 13

    Topics: Alanine; Amino Acids; Arginine; Butanones; Carboxypeptidases; Chemical Phenomena; Chemistry; Chemistry Techniques, Analytical; Chromatography; Culture Media; Electrophoresis; Glutamates; Glycine; Histidine; Indicators and Reagents; Isoleucine; Leucine; Lysine; Metabolism; Methionine; Milk; Peptide Hydrolases; Peptides; Phenylalanine; Proline; Research; Streptococcus; Threonine; Tyrosine; Valine

1965
THE PERIODATE OXIDATION OF AMINO ACIDS WITH REFERENCE TO STUDIES ON GLYCOPROTEINS.
    The Biochemical journal, 1965, Volume: 94

    Topics: Amino Acids; Cysteine; Cystine; Glycoproteins; Histidine; Hydrogen-Ion Concentration; Hydroxyproline; Indoles; Isoleucine; Leucine; Methionine; Oxidation-Reduction; Periodic Acid; Phenylalanine; Proline; Pyrroles; Research; Serine; Threonine; Tryptophan; Tyrosine

1965
THE BIOSYNTHESIS OF GRAMICIDIN S IN A CELL-FREE SYSTEM.
    The Biochemical journal, 1965, Volume: 96

    Topics: Adenosine Triphosphate; Amino Acids; Bacillus; Carbon Isotopes; Cell-Free System; Chloramphenicol; Gramicidin; Hydrogen-Ion Concentration; Leucine; Metabolism; Ornithine; Peptides; Pharmacology; Phenylalanine; Proline; Proteins; Puromycin; Pyruvate Kinase; Pyruvates; Research; Tyrothricin; Valine

1965
AMINO ACID SENSITIVITY OF STRAINS DERIVED FROM ESCHERICHIA COLI K 12.
    Acta microbiologica Academiae Scientiarum Hungaricae, 1965, Volume: 12

    Topics: Amino Acids; Bacteriological Techniques; Escherichia coli; Feedback; Genetics; Glycine; Growth; Isoleucine; Leucine; Methionine; Pharmacology; Proline; Research; Serotonin; Threonine; Tyrosine; Valine

1965
Conditions affecting Bacillus megaterium spore germination in glucose or various nitrogenous compounds.
    Journal of bacteriology, 1962, Volume: 83

    Topics: Alanine; Bacillus; Bacillus megaterium; Culture Media; Glucose; Leucine; Nitrogen; Nitrogen Compounds; Proline; Spores, Bacterial; Valine

1962
Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores.
    Journal of bacteriology, 1962, Volume: 83

    Topics: Alanine; Arginine; Asparagine; Bacillus; Bacillus megaterium; Culture Media; Cysteine; Hot Temperature; Leucine; Nitrates; Nitrogen; Proline; Spores, Bacterial; Valine

1962
Missense mutation of Pro387Leu in protein tyrosine phosphatase-1B (PTP-1B) is not associated with type 2 diabetes in a Chinese Han population.
    Diabetes care, 2003, Volume: 26, Issue:10

    Topics: Asian People; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Humans; Leucine; Mutation, Missense; Proline; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases

2003
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
    Nature neuroscience, 2003, Volume: 6, Issue:11

    Topics: Adenoviridae; Amino Acid Motifs; Amino Acid Sequence; Analysis of Variance; Androstadienes; Animals; Apoptosis; Blotting, Western; Brain; Carrier Proteins; Cell Fractionation; Cells, Cultured; Cloning, Molecular; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homer Scaffolding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; Leucine; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proline; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Synaptophysin; Transfection; Wortmannin

2003
A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis.
    Molecular and cellular neurosciences, 2003, Volume: 24, Issue:2

    Topics: Apoptosis; Cell Cycle; Cell Line; Gene Expression Regulation; Humans; Leucine; Mutation, Missense; Proline; tau Proteins

2003
Modulating calcitonin fibrillogenesis: an antiparallel alpha-helical dimer inhibits fibrillation of salmon calcitonin.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Calcitonin; Chromatography, Gel; Circular Dichroism; Dimerization; Dose-Response Relationship, Drug; Guanidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Folding; Protein Structure, Secondary; Salmon; Sequence Homology, Amino Acid

2004
P301L Tau mutation and non-Alzheimer dementias in Italy.
    Acta neurologica Scandinavica, 2003, Volume: 108, Issue:5

    Topics: Amino Acid Substitution; Basal Ganglia; Cerebral Cortex; Dementia; Humans; Italy; Leucine; Middle Aged; Mutation; Proline; tau Proteins

2003
[Familial hypocalciuric hypercalcemia].
    Orvosi hetilap, 2003, Oct-12, Volume: 144, Issue:41

    Topics: Adult; Calcium; Female; Heterozygote; Humans; Hypercalcemia; Leucine; Proline; Receptors, Calcium-Sensing; Sequence Analysis, DNA

2003
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.
    Neuron, 2003, Oct-30, Volume: 40, Issue:3

    Topics: Animals; Brain; Caspase 3; Caspases; Cell Count; Cell Fractionation; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Detergents; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Leucine; Luminescent Proteins; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Immunoelectron; Microtubules; Models, Neurological; Nerve Degeneration; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Phosphorylation; Proline; Sarcosine; tau Proteins; Time Factors

2003
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.
    Endocrinology, 2004, Volume: 145, Issue:4

    Topics: Amino Acid Sequence; Cell Line; Gene Expression; Genes, Dominant; Humans; Leucine; Ligands; Methionine; Models, Structural; Molecular Sequence Data; Monocytes; Mutation; Oxazoles; Pioglitazone; Proline; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transfection; Tyrosine; Valine

2004
Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Active Transport, Cell Nucleus; Amino Acid Motifs; Amino Acid Sequence; Apoptosis; Base Sequence; Blotting, Western; Conserved Sequence; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Gene Expression Regulation; Humans; Interferon-alpha; Interferon-beta; Interferon-gamma; Jurkat Cells; Leucine; Luciferases; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Proline; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA; Sequence Homology, Amino Acid; STAT1 Transcription Factor; STAT2 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine

2004
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
    Diabetes care, 2004, Volume: 27, Issue:2

    Topics: Adult; Amino Acid Substitution; Blood Glucose; Body Mass Index; Cholesterol; Coronary Disease; Diabetes Mellitus, Type 1; Female; Genotype; Glycated Hemoglobin; Humans; Leucine; Male; Mutation, Missense; Neuropeptide Y; Proline; Protein Precursors; Proteinuria; Risk Factors; Triglycerides

2004
Re: Integrin beta3 Leu33Pro homozygosity and risk of cancer.
    Journal of the National Cancer Institute, 2004, Feb-04, Volume: 96, Issue:3

    Topics: Alleles; Breast Neoplasms; Case-Control Studies; Female; Homozygote; Humans; Integrin beta3; Leucine; Polymorphism, Genetic; Proline; Risk Assessment; Risk Factors

2004
The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes.
    The Journal of biological chemistry, 2004, Apr-23, Volume: 279, Issue:17

    Topics: Adenosine Triphosphate; Animals; Annexin A5; Cell Membrane; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Leucine; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phospholipase D; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proline; Protein Structure, Tertiary; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Thymoma; Thymus Gland; Time Factors

2004
Hepatic amyloidosis resulting from deposition of the apolipoprotein A-I variant Leu75Pro.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2003, Volume: 10, Issue:4

    Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloidosis; Apolipoprotein A-I; DNA; Female; Genetic Variation; Humans; Leucine; Liver; Liver Diseases; Mass Spectrometry; Middle Aged; Molecular Sequence Data; Mutation; Plasma; Polymorphism, Restriction Fragment Length; Proline; Sequence Homology, Amino Acid

2003
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2004, Volume: 112, Issue:2

    Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Homozygote; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Mutation; Nuclear Proteins; Proline; Serine; Transcription Factors

2004
Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides.
    Biotechnology letters, 2004, Volume: 26, Issue:4

    Topics: Animals; Antifungal Agents; Antimicrobial Cationic Peptides; Aspergillus; Candida albicans; Circular Dichroism; Fusarium; Gene Deletion; Leucine; Magainins; Peptides; Proline; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trichosporon; Xenopus; Xenopus Proteins

2004
Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:9

    Topics: Amino Acid Sequence; Antibodies; Cell Line; Cell Line, Tumor; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Molecular Sequence Data; Mutation; Procollagen-Proline Dioxygenase; Proline; Protein Binding; Protein Processing, Post-Translational; Thermodynamics; Transcription Factors; Transcription, Genetic

2004
Functional analysis of two recurrent amino acid substitutions in the CYP21 gene from Italian patients with congenital adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:5

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Amino Acid Substitution; Animals; Child; Child, Preschool; Chlorocebus aethiops; COS Cells; Female; Humans; Infant; Infant, Newborn; Italy; Leucine; Male; Proline; Serine; Steroid 21-Hydroxylase

2004
Liver biopsy discloses a new apolipoprotein A-I hereditary amyloidosis in several unrelated Italian families.
    Gastroenterology, 2004, Volume: 126, Issue:5

    Topics: Aged; Amyloidosis; Apolipoprotein A-I; Biopsy; DNA; Female; Heterozygote; Humans; Italy; Leucine; Liver; Male; Microscopy, Immunoelectron; Middle Aged; Mutation; Pedigree; Proline

2004
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.
    The EMBO journal, 2004, Jun-02, Volume: 23, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Allosteric Regulation; Anthracenes; Arginine; Binding Sites; Blotting, Western; Calorimetry; Crystallography, X-Ray; Glutamic Acid; HeLa Cells; Humans; Hydrogen Bonding; Leucine; Mitogen-Activated Protein Kinase 8; Models, Molecular; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; Transfection

2004
Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.
    Pharmacogenetics, 2004, Volume: 14, Issue:3

    Topics: Binding, Competitive; Cell Membrane; Electrophysiology; Genetic Variation; Humans; Imidazoles; Indoles; Ion Channels; Kidney; Kinetics; Leucine; Ligands; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Proline; Protein Binding; Radioligand Assay; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists

2004
A short alpha-helical antimicrobial peptide with antibacterial selectivity.
    Biotechnology letters, 2004, Volume: 26, Issue:9

    Topics: Amino Acid Sequence; Antimicrobial Cationic Peptides; Circular Dichroism; Dose-Response Relationship, Drug; Leucine; Molecular Sequence Data; Peptides; Proline; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Tryptophan

2004
The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK.
    The Journal of biological chemistry, 2004, Aug-27, Volume: 279, Issue:35

    Topics: Adenosine Triphosphate; Alanine; Amino Acid Motifs; Animals; beta-Galactosidase; Binding, Competitive; COS Cells; Databases as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetics; Leucine; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Peptides; Plasmids; Proline; Protein Binding; Protein Structure, Tertiary; Temperature; Threonine; Transfection; Two-Hybrid System Techniques

2004
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
    The Journal of urology, 2004, Volume: 172, Issue:2

    Topics: Aged; Alanine; Asian People; Carcinoma, Transitional Cell; Female; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Logistic Models; Male; Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Superoxide Dismutase; Urinary Bladder Neoplasms; Valine

2004
Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.
    Biochemistry, 2004, Aug-10, Volume: 43, Issue:31

    Topics: Alanine; Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Cell Line; Conserved Sequence; Cysteine; Disulfides; Humans; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Proline; Protein Structure, Tertiary; Protein Subunits; Receptors, Glycine; Tryptophan

2004
Biophysical and mutational analysis of the putative bZIP domain of Epstein-Barr virus EBNA 3C.
    Journal of virology, 2004, Volume: 78, Issue:17

    Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Antigens, Viral; Cell Line, Tumor; Cell Nucleus; Circular Dichroism; Dimerization; DNA-Binding Proteins; Epstein-Barr Virus Nuclear Antigens; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leucine; Leucine Zippers; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutation; Nuclear Proteins; Proline; Protein Binding; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Viral Proteins

2004
The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.
    Amino acids, 2004, Volume: 27, Issue:1

    Topics: Alanine; Amino Acids; Arabinose; Arginine; Aspartic Acid; Biochemistry; Carbohydrates; Colorimetry; Copper; Cysteine; Fructose; Glucose; Glutamic Acid; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Ions; Iron; Isoleucine; Leucine; Lysine; Maltose; Metals; Models, Chemical; Phenylalanine; Proline; Serine; Sodium Chloride; Temperature; Time Factors; Valine; Xylose

2004
Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Glucose; Leucine; Losartan; Male; Matrix Metalloproteinases; Myocardium; Osmolar Concentration; Proline; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Vitamin E

2005
Metabolic properties of Eubacterium pyruvativorans, a ruminal 'hyper-ammonia-producing' anaerobe with metabolic properties analogous to those of Clostridium kluyveri.
    Microbiology (Reading, England), 2004, Volume: 150, Issue:Pt 9

    Topics: Adenosine Triphosphate; Alanine; Animals; Aspartic Acid; Caseins; Clostridium; Crotonates; Energy Metabolism; Eubacterium; Fatty Acids, Volatile; Fermentation; Glycine; Lactic Acid; Leucine; Peptides; Proline; Pyruvic Acid; Rumen; Serine; Threonine

2004
Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors.
    Biochemistry, 2004, Oct-05, Volume: 43, Issue:39

    Topics: Bacterial Proteins; Binding, Competitive; Cloning, Molecular; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Flavin-Adenine Dinucleotide; Furans; Humans; Leucine; Macromolecular Substances; Membrane Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Models, Molecular; Mutagenesis, Site-Directed; Peptide Fragments; Proline; Proline Oxidase; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary

2004
A case of complicated spastic paraplegia 2 due to a point mutation in the proteolipid protein 1 gene.
    Journal of the neurological sciences, 2004, Sep-15, Volume: 224, Issue:1-2

    Topics: Brain; DNA Mutational Analysis; Humans; Infant; Leucine; Magnetic Resonance Imaging; Male; Membrane Proteins; Myelin Proteolipid Protein; Paraplegia; Pelizaeus-Merzbacher Disease; Phenotype; Point Mutation; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2004
A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease.
    Journal of the American College of Cardiology, 2004, Oct-06, Volume: 44, Issue:7

    Topics: Adult; Apolipoprotein A-I; Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Heterozygote; Humans; Hyperplasia; Leucine; Male; Middle Aged; Mutation; Proline; Risk Assessment; Risk Factors

2004
Asymptomatic hereditary Alexander's disease caused by a novel mutation in GFAP.
    Journal of the neurological sciences, 2004, Oct-15, Volume: 225, Issue:1-2

    Topics: Alexander Disease; Brain; Child; DNA Mutational Analysis; Exons; Female; Glial Fibrillary Acidic Protein; Humans; Infant; Leucine; Magnetic Resonance Imaging; Male; Mutation; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2004
Actin mutations are one cause of congenital fibre type disproportion.
    Annals of neurology, 2004, Volume: 56, Issue:5

    Topics: Actins; Adenosine Triphosphatases; Aspartic Acid; Biopsy; Child, Preschool; DNA Mutational Analysis; Female; Heterozygote; Humans; Infant; Infant, Newborn; Leucine; Male; Models, Molecular; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Mutation, Missense; Myopathies, Structural, Congenital; Proline; Sequence Analysis, Protein; Serine; Valine

2004
The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
    Biochemical and biophysical research communications, 2004, Nov-12, Volume: 324, Issue:2

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acids; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Carbon Monoxide; Cytochrome P450 Family 2; Debrisoquin; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Ethanolamines; Glycine; Kinetics; Leucine; Liver; Microsomes; Microsomes, Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Proline; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Spectrophotometry; Valine

2004
Phenotypic features and genetic findings in 2 chinese families with Miyoshi distal myopathy.
    Archives of neurology, 2004, Volume: 61, Issue:10

    Topics: Adolescent; Adult; Asian People; Distal Myopathies; DNA Mutational Analysis; Dysferlin; Exons; Family Health; Female; Genetic Linkage; Genotype; Glycine; Humans; Immunohistochemistry; Leucine; Magnetic Resonance Imaging; Male; Membrane Proteins; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Mutation; Pedigree; Phenotype; Polymorphism, Single-Stranded Conformational; Proline; Valine

2004
Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the p
    The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53

    Topics: Alanine; Amino Acid Motifs; Animals; Azetidinecarboxylic Acid; Baculoviridae; Cell Line; Chromatography, Liquid; Culture Media, Serum-Free; Glutamic Acid; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Insecta; Ketoglutaric Acids; Kinetics; Leucine; Mass Spectrometry; Methionine; Models, Chemical; Peptides; Procollagen-Proline Dioxygenase; Proline; Protein Structure, Tertiary; Substrate Specificity; Time Factors; Transcription Factors

2004
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.
    The Journal of biological chemistry, 2004, Dec-24, Volume: 279, Issue:52

    Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Amino Acid Sequence; Binding Sites; Coumarins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Granzymes; Humans; Hydrolysis; Leucine; Molecular Sequence Data; Norleucine; Peptide Library; Proline; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Serpins; Structure-Activity Relationship; Substrate Specificity

2004
Renal apolipoprotein A-I amyloidosis associated with a novel mutant Leu64Pro.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 44, Issue:6

    Topics: Amino Acid Substitution; Amyloidosis, Familial; Apolipoprotein A-I; Humans; Kidney; Kidney Diseases; Leucine; Male; Middle Aged; Mutation; Proline

2004
Severe hypercalcemia in a 9-year-old Brazilian girl due to a novel inactivating mutation of the calcium-sensing receptor.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:12

    Topics: Base Sequence; Brazil; Cell Line; Child; Consanguinity; DNA; DNA Restriction Enzymes; Exons; Female; Heterozygote; Homozygote; Humans; Hypercalcemia; Immunoblotting; Leucine; Mutation, Missense; Proline; Receptors, Calcium-Sensing; Severity of Illness Index; Transfection

2004
Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Dec-21, Volume: 101, Issue:51

    Topics: Amino Acid Substitution; Bacillus; Cell Line; Cell Membrane; Cytoplasm; Humans; Ion Channel Gating; Leucine; Membrane Potentials; Mutation; Patch-Clamp Techniques; Proline; Sodium Channels

2004
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Actins; Anaphase-Promoting Complex-Cyclosome; Antibodies, Monoclonal; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Lysine; Models, Molecular; Mutation; Mutation, Missense; Neoplasms; Peptides; Plasmids; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Time Factors; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2005
Family of two patients with congenital lipoid adrenal hyperplasia due to StAR mutation.
    Endocrine research, 2004, Volume: 30, Issue:4

    Topics: Adrenal Hyperplasia, Congenital; Animals; Chlorocebus aethiops; COS Cells; Female; Humans; Infant; Leucine; Mutation; Phosphoproteins; Proline; Transfection

2004
Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement.
    Biochemistry, 2005, Feb-15, Volume: 44, Issue:6

    Topics: Binding Sites; Caprylates; Catalysis; Coenzyme A; Crystallography, X-Ray; Escherichia coli Proteins; Hydrophobic and Hydrophilic Interactions; Leucine; Lysophospholipase; Models, Molecular; Multienzyme Complexes; Palmitoyl-CoA Hydrolase; Periplasmic Proteins; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Substrate Specificity; Thermodynamics

2005
A human congenital myasthenia-causing mutation (epsilon L78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties.
    The Journal of physiology, 2005, Apr-15, Volume: 564, Issue:Pt 2

    Topics: Acetylcholine; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Humans; Leucine; Likelihood Functions; Mutation; Myasthenic Syndromes, Congenital; Proline; Receptors, Nicotinic

2005
Behavior of diphtheria toxin T domain containing substitutions that block normal membrane insertion at Pro345 and Leu307: control of deep membrane insertion and coupling between deep insertion of hydrophobic subdomains.
    Biochemistry, 2005, Mar-22, Volume: 44, Issue:11

    Topics: Amino Acid Substitution; Boron Compounds; Diphtheria Toxin; DNA Mutational Analysis; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Leucine; Lipid Bilayers; Membrane Proteins; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Spectrometry, Fluorescence

2005
The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:6

    Topics: Adult; Amino Acid Substitution; Blood Glucose; Blood Pressure; Female; Genotype; Ghrelin; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Leucine; Male; Mutation, Missense; Neuropeptide Y; Nordefrin; Peptide Hormones; Proline; Protein Precursors

2005
A novel missense mutation in the Connexin 26 gene associated with autosomal recessive sensorineural deafness.
    Hearing research, 2005, Volume: 202, Issue:1-2

    Topics: Alleles; Base Sequence; Child; Connexin 26; Connexins; Conserved Sequence; Cytosine; Female; Genes, Recessive; Hearing Loss, Sensorineural; Homozygote; Humans; Leucine; Mutation, Missense; Point Mutation; Polymorphism, Restriction Fragment Length; Proline; Thymine

2005
The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases.
    The Journal of biological chemistry, 2005, Jun-10, Volume: 280, Issue:23

    Topics: Blood Platelets; Densitometry; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Immunoblotting; Integrin beta3; Leucine; Mitogen-Activated Protein Kinase 1; Models, Biological; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Platelet Adhesiveness; Polymorphism, Genetic; Proline; Protein Isoforms; Protein Serine-Threonine Kinases; Signal Transduction; Threonine; Tyrosine

2005
17alpha-hydroxylase/17,20-Lyase deficiency due to novel compound heterozygote mutations: treatment for tall stature in a female with male pseudohermaphroditism and spontaneous puberty in her affected sister.
    Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:4

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Arginine; Body Height; Codon, Nonsense; Disorders of Sex Development; Estrogens; Estrogens, Conjugated (USP); Female; Growth Disorders; Heterozygote; Humans; Leucine; Mutation; Mutation, Missense; Orchiectomy; Proline; Puberty; Steroid 17-alpha-Hydroxylase

2005
The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.
    The Journal of biological chemistry, 2005, Jul-15, Volume: 280, Issue:28

    Topics: Alleles; Amino Acid Sequence; Animals; Blotting, Western; Calcium; Calcium Channels; Circular Dichroism; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Genetic Vectors; Glutathione Transferase; Histidine; Immunoprecipitation; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Intestinal Mucosa; Kinetics; Leucine; Ligands; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Molecular Sequence Data; Plasmids; Polymorphism, Genetic; Proline; Protein Binding; Protein Structure, Tertiary; Proteolipids; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction; Spectrometry, Fluorescence

2005
Re: Integrin beta3 Leu33Pro homozygosity and risk of cancer.
    Journal of the National Cancer Institute, 2005, May-18, Volume: 97, Issue:10

    Topics: Case-Control Studies; Codon; Denmark; Female; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Germany; Homozygote; Humans; Incidence; Integrin beta3; Leucine; Neoplasm Invasiveness; Odds Ratio; Ovarian Neoplasms; Polymorphism, Genetic; Proline; Risk Assessment; Risk Factors; Up-Regulation

2005
Hemangioblastomas of central nervous system: molecular genetic analysis and clinical management.
    Neurosurgery, 2005, Volume: 56, Issue:6

    Topics: Adult; Aged; Arginine; Central Nervous System Neoplasms; DNA Mutational Analysis; Exons; Female; Hemangioblastoma; Humans; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Biology; Mutation, Missense; Proline; Retrospective Studies; Tryptophan; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein

2005
Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2005, Volume: 113, Issue:5

    Topics: Adult; Alleles; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glucose Intolerance; Heterozygote; Humans; Insulin; Leucine; Male; Middle Aged; Neuropeptide Y; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Sex Characteristics; Sweden

2005
The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.
    Journal of medical genetics, 2006, Volume: 43, Issue:2

    Topics: Alleles; Case-Control Studies; Exons; Genetic Predisposition to Disease; Genotype; Humans; Leucine; MADS Domain Proteins; Male; MEF2 Transcription Factors; Middle Aged; Mutation; Myocardial Infarction; Myogenic Regulatory Factors; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Proline

2006
No association of breast cancer risk with integrin beta3 (ITGB3) Leu33Pro genotype.
    British journal of cancer, 2005, Jul-11, Volume: 93, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Integrin beta3; Leucine; Middle Aged; Proline

2005
Cell-penetrating cis-gamma-amino-l-proline-derived peptides.
    Journal of the American Chemical Society, 2005, Jul-06, Volume: 127, Issue:26

    Topics: Alanine; Animals; Cell Membrane; Chlorocebus aethiops; Endocytosis; Flow Cytometry; Gene Products, tat; HeLa Cells; Humans; Leucine; Microscopy, Confocal; Microscopy, Fluorescence; Peptide Hydrolases; Peptides; Phenylalanine; Proline; Temperature

2005
A novel mutation L260P of the steroidogenic acute regulatory protein gene in three unrelated patients of Swiss ancestry with congenital lipoid adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:9

    Topics: Adrenal Hyperplasia, Congenital; DNA Mutational Analysis; Female; Humans; Infant; Leucine; Microsatellite Repeats; Mutation, Missense; Pedigree; Phosphoproteins; Pregnenolone; Proline; Switzerland

2005
JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain.
    The Journal of biological chemistry, 2005, Aug-26, Volume: 280, Issue:34

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Cloning, Molecular; Cytoplasm; DNA, Complementary; Genes, Dominant; Genetic Vectors; Glutathione Transferase; Immunoprecipitation; Kinesins; Leucine; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Models, Biological; Mutation; Neurons; NIH 3T3 Cells; Peptides; Proline; Protein Binding; Protein Structure, Tertiary; Retroviridae; Signal Transduction; Two-Hybrid System Techniques; Valine

2005
Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects.
    Neuropsychobiology, 2005, Volume: 52, Issue:2

    Topics: Adult; Analysis of Variance; Female; Gene Frequency; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Japan; Leucine; Male; Middle Aged; Personality; Personality Inventory; Polymorphism, Genetic; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2005
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
    Bioorganic & medicinal chemistry, 2005, Aug-15, Volume: 13, Issue:16

    Topics: Amino Acids; Aminopeptidases; Animals; Binding Sites; Escherichia coli; Kinetics; Leucine; Proline; Protease Inhibitors; Pyrroles; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles

2005
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise.
    The Journal of physiology, 2005, Sep-15, Volume: 567, Issue:Pt 3

    Topics: Adult; Carbon Radioisotopes; Collagen; Exercise; Hemiterpenes; Humans; Keto Acids; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Myofibrils; Nitrogen Radioisotopes; Patella; Proline; Sarcoplasmic Reticulum; Tendons; Thigh; Valine

2005
Proton affinity of diastereoisomers of modified prolines using the kinetic method and density functional theory calculations: role of the cis/trans substituent on the endo/exo ring conformation.
    Rapid communications in mass spectrometry : RCM, 2005, Volume: 19, Issue:16

    Topics: Algorithms; Glutamic Acid; Kinetics; Leucine; Models, Molecular; Molecular Conformation; Proline; Stereoisomerism; Thermodynamics

2005
Four novel connexin 32 mutations in X-linked Charcot-Marie-Tooth disease with phenotypic variability.
    Journal of neurology, 2006, Volume: 253, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Charcot-Marie-Tooth Disease; Chromosomes, Human, X; Codon, Terminator; Connexins; DNA Mutational Analysis; Family Health; Female; Gap Junction beta-1 Protein; Humans; Leucine; Male; Middle Aged; Mutation; Phenotype; Phenylalanine; Proline; Serine; Tyrosine; Valine

2006
Resonance assignments for mouse S100A13.
    Journal of biomolecular NMR, 2005, Volume: 32, Issue:3

    Topics: Animals; Binding Sites; Leucine; Lysine; Magnetic Resonance Spectroscopy; Mice; Proline; Protein Conformation; S100 Proteins

2005
Marked phenotypic variation in a family with a new myelin protein zero mutation.
    Neuromuscular disorders : NMD, 2005, Volume: 15, Issue:11

    Topics: Adult; DNA Mutational Analysis; Family Health; Female; Hereditary Sensory and Motor Neuropathy; Humans; Leucine; Male; Mutation; Myelin P0 Protein; Neural Conduction; Pedigree; Phenotype; Proline

2005
Effect of individual amino acids and glucose on activation and germination of Rhizopus oligosporus sporangiospores in tempe starter.
    Journal of applied microbiology, 2005, Volume: 99, Issue:5

    Topics: Alanine; Amino Acids; Arginine; Betaine; Colony Count, Microbial; Culture Media; Food Handling; Food Microbiology; Germination; Glucose; Glycine max; Isoleucine; Leucine; Phosphates; Proline; Rhizopus; Spores, Fungal

2005
Effect of latanoprost on cultured porcine corneal stromal cells.
    Current eye research, 2005, Volume: 30, Issue:10

    Topics: Animals; Benzalkonium Compounds; Calcium; Cell Movement; Cells, Cultured; Collagen Type I; Corneal Stroma; Fibronectins; Fluorescent Antibody Technique; Immunoblotting; Intracellular Membranes; Latanoprost; Leucine; Proline; Prostaglandins F, Synthetic; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Thymidine; Uridine

2005
Increased risk of ovarian cancer in integrin beta3 Leu33Pro homozygotes.
    Endocrine-related cancer, 2005, Volume: 12, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Case-Control Studies; Female; Genetic Predisposition to Disease; Homozygote; Humans; Integrin beta3; Leucine; Middle Aged; Odds Ratio; Ovarian Neoplasms; Proline; Risk Factors

2005
Induction of a protein-targeted catalytic response in autoimmune prone mice: antibody-mediated cleavage of HIV-1 glycoprotein GP120.
    Biochemistry, 2006, Jan-10, Volume: 45, Issue:1

    Topics: Animals; Antibodies, Catalytic; Antibody Affinity; Autoimmune Diseases; Catalysis; Electrophoresis, Polyacrylamide Gel; Encephalomyelitis, Autoimmune, Experimental; Fluorescent Dyes; HIV Envelope Protein gp120; HIV-1; Immunoglobulin G; Leucine; Mice; Peptide Fragments; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Viral Vaccines

2006
Biochemical activities of the BOB1 mutant in Methanobacterium thermoautotrophicum MCM.
    Biochemistry, 2006, Jan-17, Volume: 45, Issue:2

    Topics: Adenosine Triphosphatases; Amino Acid Substitution; Binding Sites; Cell Cycle Proteins; Cloning, Molecular; Conserved Sequence; DNA Helicases; DNA, Archaeal; DNA, Mitochondrial; DNA, Single-Stranded; Evolution, Molecular; Leucine; Methanobacterium; Minichromosome Maintenance 1 Protein; Proline; Saccharomyces cerevisiae Proteins

2006
Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin.
    Molecular vision, 2005, Dec-31, Volume: 11

    Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Electrophysiology; Immunohistochemistry; Kinetics; Leucine; Light; Mutation; Proline; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Rhodopsin; Swine; Vision, Ocular

2005
Factor XIIIa mediated attachment of S. aureus fibronectin-binding protein A (FnbA) to fibrin: identification of Gln103 as a major cross-linking site.
    Biochemistry, 2006, Feb-14, Volume: 45, Issue:6

    Topics: Adhesins, Bacterial; Base Sequence; Binding Sites; Catalysis; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Factor XIIIa; Fibrin; Glutamine; Leucine; Lysine; Proline; Staphylococcus aureus; Time Factors; Urea

2006
Phenotypic and cellular expression of two novel connexin32 mutations causing CMT1X.
    Neurology, 2006, Feb-14, Volume: 66, Issue:3

    Topics: Aged; Amino Acid Substitution; Central Nervous System Diseases; Charcot-Marie-Tooth Disease; Connexins; Demyelinating Diseases; Electromyography; Female; Gap Junction beta-1 Protein; Glutamic Acid; HeLa Cells; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Neural Conduction; Pedigree; Phenotype; Polyneuropathies; Proline; Sural Nerve; Valine

2006
Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population.
    Neurology, 2006, Feb-14, Volume: 66, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Asparagine; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Glucosylceramidase; Heterozygote; Humans; Leucine; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Serine

2006
Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1).
    Molecular vision, 2006, Apr-10, Volume: 12

    Topics: Acidosis, Renal Tubular; Adult; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Cell Membrane; Eye Diseases; Homozygote; Humans; Leucine; Male; Molecular Sequence Data; Mutation, Missense; Oocytes; Proline; Sodium-Bicarbonate Symporters; Xenopus

2006
Presymptomatic genetic diagnosis for consulters from a large Chinese family with juvenile open angle glaucoma.
    Molecular vision, 2006, Apr-17, Volume: 12

    Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Asian People; Cytoskeletal Proteins; Eye Proteins; Female; Genes, Dominant; Genetic Predisposition to Disease; Glaucoma, Open-Angle; Glycoproteins; Heterozygote; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Phenotype; Proline

2006
Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa.
    Molecular vision, 2006, May-09, Volume: 12

    Topics: Asian People; c-Mer Tyrosine Kinase; DNA Mutational Analysis; Exons; Gene Frequency; Genes, Recessive; Homozygote; Humans; Introns; Leucine; Mutation; Mutation, Missense; Proline; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Retinitis Pigmentosa

2006
Role of the C-terminal fragment of human transthyretin in abnormal fibrillogenesis.
    Biochemistry. Biokhimiia, 2006, Volume: 71, Issue:5

    Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Humans; Leucine; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Prealbumin; Proline; Protease Inhibitors; Protein Binding; Protein Structure, Quaternary; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006
GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer.
    Cancer letters, 2007, Mar-18, Volume: 247, Issue:2

    Topics: Alcohol Drinking; Cohort Studies; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Lung Neoplasms; Middle Aged; Polymorphism, Genetic; Proline; Risk Factors; Smoking

2007
Clinical features of hereditary spastic paraplegia due to spastin mutation.
    Neurology, 2006, Jul-11, Volume: 67, Issue:1

    Topics: Adenosine Triphosphatases; Adult; Aged; Cohort Studies; DNA Mutational Analysis; Exons; Female; Genetic Testing; Glutamine; Humans; Leucine; Male; Middle Aged; Mutation; Phenotype; Proline; Retrospective Studies; Serine; Spastic Paraplegia, Hereditary; Spastin; United Kingdom

2006
Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside Europe.
    Clinical chemistry and laboratory medicine, 2006, Volume: 44, Issue:9

    Topics: Cytosine; Europe; Female; Genetic Predisposition to Disease; Granuloma; Humans; Leucine; Male; Peptidyl-Dipeptidase A; Point Mutation; Proline; Thymine

2006
Molecular assay for detection of the common carnitine palmitoyltransferase 1A 1436(C>T) mutation.
    Clinical chemistry and laboratory medicine, 2006, Volume: 44, Issue:9

    Topics: Amino Acid Substitution; Base Sequence; Biological Assay; Carnitine O-Palmitoyltransferase; Cytosine; Female; Genotype; Heterozygote; Humans; Infant; Leucine; Lipid Metabolism; Male; Point Mutation; Proline; Reverse Transcriptase Polymerase Chain Reaction; Thymine

2006
Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area.
    The Biochemical journal, 2007, Jan-01, Volume: 401, Issue:1

    Topics: Animals; Calcium; Hindlimb; Humans; Kinetics; Leucine; Malignant Hyperthermia; Models, Genetic; Models, Molecular; Mutation; Proline; Protein Structure, Secondary; Rabbits; Ryanodine Receptor Calcium Release Channel

2007
Late-onset metachromatic leukodystrophy: genotype strongly influences phenotype.
    Neurology, 2006, Sep-12, Volume: 67, Issue:5

    Topics: Adolescent; Adult; Cerebroside-Sulfatase; Child; Electroencephalography; Female; Genotype; Humans; Isoleucine; Leucine; Leukodystrophy, Metachromatic; Magnetic Resonance Imaging; Male; Mutation; Neural Conduction; Phenotype; Proline; Statistics, Nonparametric

2006
A novel mutation of PAX3 in a Chinese family with Waardenburg syndrome.
    Molecular vision, 2006, Aug-28, Volume: 12

    Topics: Amino Acid Substitution; Asian People; Child, Preschool; Chromosomes, Human, Pair 2; Cytosine; DNA Mutational Analysis; Female; Genetic Linkage; Haplotypes; Heterozygote; Humans; Leucine; Lod Score; Male; Mutation; Paired Box Transcription Factors; PAX3 Transcription Factor; Pedigree; Phenotype; Proline; Thymine; Waardenburg Syndrome

2006
Can mutations in gamma-actin modulate the toxicity of microtubule targeting agents?
    Journal of the National Cancer Institute, 2006, Oct-04, Volume: 98, Issue:19

    Topics: Actins; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leucine; Microtubules; Mutation; Neoplasms; Proline; RNA, Small Interfering; Tubulin; Tubulin Modulators; Valine; Vincristine

2006
Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia.
    Journal of the National Cancer Institute, 2006, Oct-04, Volume: 98, Issue:19

    Topics: Actins; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Child; DNA Mutational Analysis; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Epothilones; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Leucine; Mass Spectrometry; Mice; Microtubules; Mutation; Neuroblastoma; Plasmids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection; Tubulin; Tubulin Modulators; Tumor Stem Cell Assay; Valine; Vinblastine

2006
Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains.
    The Journal of biological chemistry, 2006, Dec-29, Volume: 281, Issue:52

    Topics: Amino Acid Motifs; Carrier Proteins; Humans; Huntington Disease; Leucine; Ligands; Magnetic Resonance Spectroscopy; Peptides; Proline; Proline-Rich Protein Domains; Protein Structure, Tertiary; Rett Syndrome; Ribonucleoprotein, U1 Small Nuclear; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Tryptophan

2006
Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome.
    Circulation, 2006, Nov-07, Volume: 114, Issue:19

    Topics: Brugada Syndrome; Genetic Carrier Screening; Humans; Isoleucine; Leucine; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Pedigree; Phenotype; Proline; Sodium Channels; Valine

2006
Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms.
    Neuroscience letters, 2007, Jan-03, Volume: 411, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; MADS Domain Proteins; Male; MEF2 Transcription Factors; Middle Aged; Myogenic Regulatory Factors; Odds Ratio; Peptides; Polymorphism, Genetic; Proline

2007
Identification of a novel mutation in the spastin gene (SPG4) in an Italian family with hereditary spastic paresis.
    Panminerva medica, 2006, Volume: 48, Issue:3

    Topics: Adenosine Triphosphatases; Adult; Aged; Cytosine; Exons; Female; Genes, Dominant; Humans; Italy; Leucine; Magnetic Resonance Imaging; Male; Mutation, Missense; Proline; Spastic Paraplegia, Hereditary; Spastin; Thymine

2006
A novel P755L mutation in LRRK2 gene associated with Parkinson's disease.
    Neuroreport, 2006, Dec-18, Volume: 17, Issue:18

    Topics: Adult; Aged; Aged, 80 and over; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2006
Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population.
    International journal of cancer, 2007, Mar-15, Volume: 120, Issue:6

    Topics: Alleles; Asian People; China; Female; Humans; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Sequence Analysis, DNA; Stomach Neoplasms; Transforming Growth Factor beta1; Transforming Growth Factor beta2

2007
Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
    Journal of medical genetics, 2007, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Alleles; BRCA1 Protein; Breast Neoplasms; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Integrin beta3; Leucine; Middle Aged; Ovarian Neoplasms; Polymorphism, Genetic; Proline

2007
A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect.
    Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:4

    Topics: Aspartic Acid; Binding Sites; Blood Coagulation; Catalysis; Chymotrypsin; Factor XI; Humans; Kinetics; Leucine; Models, Molecular; Proline; Protein Binding; Recombinant Proteins; Serine Endopeptidases

2007
Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.
    Annals of the New York Academy of Sciences, 2006, Volume: 1089

    Topics: Alleles; Amino Acid Substitution; Carcinoma; Case-Control Studies; Colorectal Neoplasms; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Interleukin-10; Italy; Leucine; Male; Polymorphism, Single Nucleotide; Proline; Risk; Transforming Growth Factor beta1

2006
Integrin beta3 Leu33Pro polymorphism and risk of hip fracture: 25 years follow-up of 9233 adults from the general population.
    Pharmacogenetics and genomics, 2007, Volume: 17, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Bone Density; Denmark; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Hip Fractures; Homozygote; Humans; Integrin beta3; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Prospective Studies; Risk Factors

2007
Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.
    European journal of clinical nutrition, 2007, Volume: 61, Issue:9

    Topics: Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Ghrelin; Humans; Hypertension; Insulin; Insulin Secretion; Leucine; Male; Middle Aged; Neuropeptide Y; Peptide Hormones; Polymorphism, Genetic; Proline; Protein Precursors; Risk Factors

2007
Two novel epilepsy-linked mutations leading to a loss of function of LGI1.
    Archives of neurology, 2007, Volume: 64, Issue:2

    Topics: Adult; Blotting, Western; DNA Mutational Analysis; Epilepsy; Exons; Family Health; Female; Genetic Linkage; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Mutation; Proline; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index

2007
Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration.
    Acta ophthalmologica Scandinavica, 2007, Volume: 85, Issue:2

    Topics: Aged; Aged, 80 and over; Amino Acid Substitution; Exudates and Transudates; Female; Genotype; Humans; Leucine; Macular Degeneration; Male; Neuropeptide Y; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Protein Sorting Signals; Risk Factors

2007
Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cells.
    The Journal of physiology, 2007, May-01, Volume: 580, Issue:Pt.3

    Topics: Animals; Calcium Channels, L-Type; Caveolin 3; Cells, Cultured; Electric Conductivity; Embryo, Mammalian; Leucine; Mice; Muscle Cells; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies; Mutation; Proline; Tissue Distribution

2007
Amino acid and codon use: in two influenza viruses and three hosts.
    Medecine et maladies infectieuses, 2007, Volume: 37, Issue:6

    Topics: Alanine; Amino Acids; Animals; Chickens; Codon; Humans; Influenza A virus; Influenza B virus; Leucine; Proline; Swine

2007
Unique side chain conformation of a Leu residue in a triple-helical structure.
    Biopolymers, 2007, Jun-15, Volume: 86, Issue:3

    Topics: Amino Acid Sequence; Crystallography, X-Ray; Glycine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Hypoxanthine; Leucine; Models, Chemical; Oligopeptides; Oxygen; Proline; Protein Conformation; Protein Structure, Secondary; Water

2007
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer.
    Journal of virology, 2007, Volume: 81, Issue:11

    Topics: Amino Acid Sequence; Cell Line; Herpesvirus 8, Human; Humans; Immediate-Early Proteins; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Open Reading Frames; Proline; Protein Structure, Quaternary; Sarcoma, Kaposi; Trans-Activators; Viral Proteins; Virus Activation

2007
The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in
    The Journal of biological chemistry, 2007, Jun-01, Volume: 282, Issue:22

    Topics: Amino Acid Substitution; Animals; Catalysis; Cathepsins; Dicrocoelium; Enzyme Activation; Enzyme Precursors; Helminth Proteins; Hydrogen-Ion Concentration; Leucine; Mutation, Missense; Proline; Protein Processing, Post-Translational

2007
Structural and functional basis of amino acid specificity in the invertebrate cotransporter KAAT1.
    The Journal of physiology, 2007, Jun-15, Volume: 581, Issue:Pt 3

    Topics: Amino Acid Sequence; Amino Acid Transport Systems, Neutral; Amino Acids; Animals; Binding, Competitive; Carrier Proteins; Computer Simulation; Female; Insect Proteins; Kinetics; Leucine; Manduca; Membrane Potentials; Membrane Proteins; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Patch-Clamp Techniques; Potassium; Proline; Protein Binding; Protein Conformation; Sodium; Threonine; Xenopus laevis

2007
Myocilin mutations among primary open angle glaucoma patients of Kanyakumari district, South India.
    Molecular vision, 2007, Apr-02, Volume: 13

    Topics: Aged; Asian People; Base Sequence; Cytoskeletal Proteins; Eye Proteins; Female; Glaucoma, Open-Angle; Glycoproteins; Humans; India; Leucine; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Proline; Serine; Threonine; Tyrosine

2007
Role of chromosomal and plasmid-borne receptor homologues in the response of Bacillus megaterium QM B1551 spores to germinants.
    Journal of bacteriology, 2007, Volume: 189, Issue:12

    Topics: Bacillus megaterium; Bacterial Proteins; Biological Transport; Bromides; Chromosomes, Bacterial; DNA, Bacterial; Genes, Bacterial; Genetic Complementation Test; Glucose; Leucine; Membrane Proteins; Molecular Sequence Data; Operon; Plasmids; Potassium Compounds; Proline; Sequence Analysis, DNA; Sequence Deletion; Spores, Bacterial; Transformation, Bacterial

2007
The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components.
    Journal of immunology (Baltimore, Md. : 1950), 2007, May-15, Volume: 178, Issue:10

    Topics: Acholeplasma laidlawii; Amino Acid Sequence; Amino Acid Substitution; Bacteria; Cell Line; Cell Wall; Genetic Variation; Humans; Immunity, Innate; Leucine; Lipoproteins; Molecular Sequence Data; Mycobacterium smegmatis; Polymorphism, Single Nucleotide; Porphyromonas gingivalis; Proline; Toll-Like Receptor 1

2007
The rare Hb Showa-Yakushiji [beta110(G12)Leu-->Pro, CTG-->CCG] in combination with an alpha gene triplication found in a Dutch patient during her first pregnancy examination.
    Hemoglobin, 2007, Volume: 31, Issue:2

    Topics: Adult; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; DNA; Female; Hemoglobins, Abnormal; Humans; Leucine; Mutation; Polymorphism, Single Nucleotide; Pregnancy; Proline

2007
Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.
    Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:2

    Topics: Arginine; Asian People; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; Exons; Gene Frequency; Genotype; Glutamic Acid; Humans; Introns; Japan; Leucine; Polymorphism, Single Nucleotide; Proline

2007
Pro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecular meshwork cells.
    Molecular vision, 2007, Apr-19, Volume: 13

    Topics: Adult; Cells, Cultured; Cytoskeletal Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Eukaryotic Initiation Factor-2; Eye Proteins; Glycoproteins; Heat-Shock Proteins; Humans; Leucine; Membrane Potential, Mitochondrial; Molecular Chaperones; Mutation; Phosphorylation; Proline; RNA, Messenger; Stress, Physiological; Trabecular Meshwork; Transfection

2007
Impact of the Leu7Pro polymorphism of preproNPY on diurnal NPY and hormone secretion in type 2 diabetes.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2007, Volume: 115, Issue:5

    Topics: Aged; Amino Acid Substitution; Blood Glucose; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Female; Humans; Hydrocortisone; Leptin; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors

2007
Enzyme replacement therapy in 12 patients with MPS I-H/S with homozygous p.Leu490Pro mutation.
    Journal of inherited metabolic disease, 2007, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Cohort Studies; Female; Homozygote; Humans; Iduronidase; Leucine; Male; Mucopolysaccharidosis I; Mutation, Missense; Pakistan; Pedigree; Proline; Recombinant Proteins; Treatment Outcome; United Kingdom

2007
Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site.
    Biochemistry, 2007, Jul-24, Volume: 46, Issue:29

    Topics: Alanine; Binding Sites; Kinetics; Leucine; Proline; Protein Conformation; Protein Structure, Tertiary; Receptor, PAR-1; Receptors, Thrombin; Recombinant Fusion Proteins; Thrombin

2007
Enhanced preference for pi-bond containing substrates is correlated to Pro110 in the substrate-binding tunnel of Escherichia coli thioesterase I/protease I/lysophospholipase L(1).
    Biochimica et biophysica acta, 2007, Volume: 1774, Issue:8

    Topics: Amino Acid Substitution; Escherichia coli; Escherichia coli Proteins; Leucine; Lysophospholipase; Mutation, Missense; Periplasmic Proteins; Proline; Protein Structure, Tertiary; Substrate Specificity; Triglycerides

2007
[A novel mutation in infant hypophophatasia: a case report].
    La Tunisie medicale, 2007, Volume: 85, Issue:5

    Topics: Alkaline Phosphatase; Exons; Follow-Up Studies; Homozygote; Humans; Hypophosphatasia; Infant; Leucine; Male; Mutation; Proline

2007
Adult onset cerebral form of X-linked adrenoleukodystrophy with dementia of frontal lobe type with new L160P mutation in ABCD1 gene.
    Journal of the neurological sciences, 2007, Dec-15, Volume: 263, Issue:1-2

    Topics: Adrenoleukodystrophy; Adult; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Dementia; Disease Progression; DNA Mutational Analysis; Family Health; Female; Follow-Up Studies; Humans; Leucine; Magnetic Resonance Imaging; Male; Mutation; Proline

2007
Study of antibodies to PMP22, IL-6 and TNF-alpha concentrations in serum in a CMTX1 family.
    Neuroscience letters, 2007, Sep-07, Volume: 424, Issue:2

    Topics: Antibodies; Charcot-Marie-Tooth Disease; China; Chromosomes, Human, X; Connexins; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Family Health; Female; Gap Junction beta-1 Protein; Humans; Interleukin-6; Leucine; Male; Myelin Proteins; Point Mutation; Proline; Sex Factors; Tumor Necrosis Factor-alpha

2007
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Aug-22, Volume: 27, Issue:34

    Topics: Age Factors; Analysis of Variance; Animals; Antibodies; Behavior, Animal; Brain; Cell Line, Tumor; Dementia; Disease Models, Animal; Humans; Immunotherapy; Leucine; Mice; Mice, Transgenic; Motor Activity; Neuroblastoma; Proline; Psychomotor Performance; Recognition, Psychology; Sex Factors; tau Proteins

2007
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
    International journal of cancer, 2007, Dec-15, Volume: 121, Issue:12

    Topics: Adult; Age of Onset; Aged; Asian People; Black or African American; Breast Neoplasms; Case-Control Studies; Checkpoint Kinase 2; DNA Mutational Analysis; DNA, Complementary; Female; Gene Frequency; Genetic Predisposition to Disease; Germ-Line Mutation; Hawaii; Hispanic or Latino; Histidine; Humans; Isoleucine; Leucine; Male; Middle Aged; Mutation; Mutation, Missense; Predictive Value of Tests; Proline; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Risk Assessment; Risk Factors; Threonine; Tyrosine; United States; White People

2007
MYOC gene mutations in Spanish patients with autosomal dominant primary open-angle glaucoma: a founder effect in southeast Spain.
    Molecular vision, 2007, Sep-13, Volume: 13

    Topics: Adolescent; Adult; Age of Onset; Child; Child, Preschool; Colombia; Cytoskeletal Proteins; Eye Proteins; Female; Founder Effect; Genes, Dominant; Glaucoma, Open-Angle; Glycoproteins; Haplotypes; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Phenotype; Proline; Retrospective Studies; Spain

2007
An unusual presentation of macular corneal dystrophy associated with uniparental isodisomy and a novel Leu173Pro mutation.
    Ophthalmic genetics, 2007, Volume: 28, Issue:3

    Topics: Adult; Amino Acid Sequence; Carbohydrate Sulfotransferases; Conserved Sequence; Cornea; Corneal Dystrophies, Hereditary; Genotype; Homozygote; Humans; Keratan Sulfate; Leucine; Male; Mutation; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Sulfotransferases; Uniparental Disomy

2007
Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.
    Brain research, 2007, Dec-05, Volume: 1183

    Topics: Amino Acid Transport Systems, Neutral; Animals; Behavior, Animal; Biological Transport, Active; Cysteine; DNA Primers; Gene Deletion; Hydrogen-Ion Concentration; Leucine; Maze Learning; Mice; Mice, Knockout; Motor Activity; Phenotype; Postural Balance; Proline; Psychomotor Performance; Smell; Synaptosomes

2007
Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu.
    Archives of biochemistry and biophysics, 2008, Jan-15, Volume: 469, Issue:2

    Topics: Aminopeptidases; Binding Sites; Biochemistry; Crystallography, X-Ray; Escherichia coli; Leucine; Models, Chemical; Molecular Conformation; Mutation; Peptides; Proline; Substrate Specificity; Valine

2008
Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations.
    European journal of endocrinology, 2007, Volume: 157, Issue:5

    Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Single Nucleotide; Proline; Sweden; United States

2007
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
    Nucleic acids research, 2008, Volume: 36, Issue:2

    Topics: Amino Acid Substitution; DNA; DNA Polymerase beta; DNA Repair; Humans; Kinetics; Leucine; Models, Molecular; Phosphorus-Oxygen Lyases; Proline; Schiff Bases; Stomach Neoplasms

2008
Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery atherosclerosis: the Helsinki Sudden Death Study.
    Atherosclerosis, 2008, Volume: 199, Issue:2

    Topics: Adult; Aged; Autopsy; Coronary Artery Disease; Gene Expression Regulation; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Sorting Signals; Risk

2008
Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy.
    Movement disorders : official journal of the Movement Disorder Society, 2008, Feb-15, Volume: 23, Issue:3

    Topics: Aged; Asparagine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glucosylceramidase; Humans; Italy; Leucine; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Serine

2008
Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: Androstadienes; Animals; Atrial Natriuretic Factor; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; Leucine; Male; Molecular Structure; Myocytes, Cardiac; Phenanthrenes; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin

2008
What causes paramyotonia in the United Kingdom? Common and new SCN4A mutations revealed.
    Neurology, 2008, Jan-01, Volume: 70, Issue:1

    Topics: Action Potentials; Arginine; Cohort Studies; Exons; Female; Humans; Leucine; Male; Mutation; Myotonic Disorders; NAV1.4 Voltage-Gated Sodium Channel; Neural Conduction; Proline; Sodium Channels; United Kingdom

2008
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD.
    Public health nutrition, 2008, Volume: 11, Issue:11

    Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Alleles; Cardiovascular Diseases; Child; Child Nutritional Physiological Phenomena; Cholesterol, LDL; Female; Finland; Genetic Predisposition to Disease; Genotype; Health Education; Humans; Leucine; Lipids; Male; Neuropeptide Y; Overweight; Polymorphism, Genetic; Proline; Public Health; Risk Factors; Sex Factors; Thinness

2008
Spermatogenic and steroidogenic impairment of the testicle characterizes the hereditary leucine-75-proline apolipoprotein a-I amyloidosis.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:5

    Topics: Adult; Aged; Amyloidosis, Familial; Apolipoprotein A-I; Humans; Leucine; Lipids; Male; Middle Aged; Proline; Spermatogenesis; Steroids; Testis

2008
Morphology of the sella turcica in Axenfeld-Rieger syndrome with PITX2 mutation.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2008, Volume: 37, Issue:8

    Topics: Adolescent; Cephalometry; Chromosomes, Human, Pair 13; Codon; Cranial Fossa, Posterior; Craniofacial Abnormalities; Cytosine; Eye Abnormalities; Facial Bones; Female; Forkhead Transcription Factors; Heterozygote; Homeobox Protein PITX2; Homeodomain Proteins; Humans; Leucine; Male; Malocclusion, Angle Class III; Maxilla; Middle Aged; Mutation, Missense; Proline; Sella Turcica; Syndrome; Thymine; Tooth Abnormalities; Transcription Factors; Young Adult

2008
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
    Archives of neurology, 2008, Volume: 65, Issue:3

    Topics: Aged; Asparagine; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glucosylceramidase; Humans; Leucine; Lewy Body Disease; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Risk Factors; Serine

2008
Metachromatic leukodystrophy: genetics, pathogenesis and therapeutic options.
    Acta paediatrica (Oslo, Norway : 1992), 2008, Volume: 97, Issue:457

    Topics: Animals; Disease Models, Animal; Hematopoietic Stem Cell Transplantation; Humans; Leucine; Leukodystrophy, Metachromatic; Mice; Mice, Transgenic; Mutation, Missense; Phenotype; Proline

2008
Matched regulation of gastrointestinal performance in the Burmese python, Python molurus.
    The Journal of experimental biology, 2008, Volume: 211, Issue:Pt 7

    Topics: alpha-Glucosidases; Aminopeptidases; Amylases; Animals; Biological Transport; Boidae; Feeding Behavior; Gastric Mucosa; Gastrointestinal Tract; Glucose; Intestines; Leucine; Myanmar; Organ Size; Pancreas; Pepsin A; Proline; Trypsin

2008
Parkinson's disease and the heterozygous state for glucocerebrosidase mutations among Brazilians.
    Parkinsonism & related disorders, 2009, Volume: 15, Issue:1

    Topics: Adult; Asparagine; Brazil; Female; Glucosylceramidase; Heterozygote; Humans; Leucine; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Serine

2009
Charcot-Marie-Tooth disease type 4C4 caused by a novel Pro153Leu substitution in the GDAP1 gene.
    Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2007, Volume: 26, Issue:2

    Topics: Adult; Amino Acid Sequence; Charcot-Marie-Tooth Disease; Genotype; GTP Phosphohydrolases; Humans; Leucine; Male; Membrane Proteins; Membrane Transport Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscular Atrophy; Mutation; Nerve Tissue Proteins; Phenotype; Poland; Proline

2007
Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.
    Brain research, 2008, Jun-12, Volume: 1214

    Topics: Age Factors; Aged; Aged, 80 and over; Animals; Brain; Calcium-Binding Proteins; DNA-Binding Proteins; Female; Histocompatibility Antigens Class II; Humans; Leucine; Male; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Microscopy, Electron, Transmission; Middle Aged; Mutation; Proline; Receptors, Scavenger; tau Proteins; Tauopathies

2008
Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R(P132L) show the different intracellular localization in vitro.
    Biomedical research (Tokyo, Japan), 2008, Volume: 29, Issue:2

    Topics: 3T3 Cells; Amino Acid Substitution; Animals; Cyclic AMP; Gene Expression Regulation; Humans; Intracellular Space; Leucine; Mice; Osteochondrodysplasias; Parathyroid Hormone; Proline; Protein Transport; Rats; Receptor, Parathyroid Hormone, Type 1

2008
Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort.
    The American journal of clinical nutrition, 2008, Volume: 87, Issue:6

    Topics: Adipose Tissue; Adult; Aged; Amino Acid Substitution; Body Size; Cohort Studies; DNA Primers; Female; Gene Frequency; Genetic Variation; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Insulin Resistance; Japan; Leucine; Longevity; Longitudinal Studies; Male; Metabolic Syndrome; Middle Aged; Polymorphism, Single Nucleotide; Proline; Sex Characteristics

2008
Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype.
    Molecular vision, 2008, Aug-22, Volume: 14

    Topics: Adult; Age of Onset; Aged; Amino Acid Sequence; Animals; Asian People; China; Chromosomes, Human, Pair 1; Cytoskeletal Proteins; Eye; Eye Proteins; Family; Female; Glaucoma, Open-Angle; Glycoproteins; Haplotypes; Humans; Leucine; Lod Score; Male; Microsatellite Repeats; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Phenotype; Proline

2008
The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine.
    Molecular pharmacology, 2008, Volume: 74, Issue:6

    Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Animals; CHO Cells; Cricetinae; Cricetulus; Glycine; Humans; In Vitro Techniques; Leucine; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; PC12 Cells; Proline; Rats; RNA, Small Interfering; Synaptic Vesicles

2008
A novel LMNA gene mutation Leu162Pro and the associated clinical characteristics in a family with autosomal-dominant emery-dreifuss muscular dystrophy.
    Muscle & nerve, 2008, Volume: 38, Issue:4

    Topics: Adult; Age of Onset; Amino Acid Substitution; Chromatin; Chromosome Disorders; DNA Mutational Analysis; Endothelial Cells; Female; Genes, Recessive; Genetic Markers; Genetic Predisposition to Disease; Humans; Lamin Type A; Leucine; Male; Muscle, Skeletal; Muscular Dystrophy, Emery-Dreifuss; Nuclear Envelope; Pedigree; Point Mutation; Proline

2008
Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase.
    Journal of molecular biology, 2008, Dec-05, Volume: 384, Issue:1

    Topics: Amino Acid Substitution; Ampicillin; beta-Lactamases; Crystallography, X-Ray; Enzyme Stability; Escherichia coli; Hydrolysis; Kinetics; Leucine; Microbial Sensitivity Tests; Microbial Viability; Mutant Proteins; Periplasmic Proteins; Plasmids; Proline; Protein Structure, Secondary; Selection, Genetic; Suppression, Genetic; Thermodynamics

2008
Absolute side-chain structure at position 13 is required for the inhibitory activity of bromein.
    The Journal of biological chemistry, 2008, Dec-26, Volume: 283, Issue:52

    Topics: Amino Acid Sequence; Ananas; Bromelains; Circular Dichroism; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Leucine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Proline; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Threonine

2008
Altered functional properties of a TRPM2 variant in Guamanian ALS and PD.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Nov-18, Volume: 105, Issue:46

    Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Calcium; Calcium Signaling; Cell Membrane; Conserved Sequence; Cyanobacteria Toxins; Evolution, Molecular; Guam; Humans; Hydrogen Peroxide; Ion Channel Gating; Leucine; Magnesium; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Mutation; Oxidative Stress; Parkinsonian Disorders; Proline; Temperature; TRPM Cation Channels

2008
The intracellular mobility of NPY and a putative mitochondrial form of NPY in neuronal cells.
    Neuroscience letters, 2009, Jan-30, Volume: 450, Issue:2

    Topics: Cell Line, Tumor; Green Fluorescent Proteins; Humans; Leucine; Microscopy, Confocal; Mitochondria; Neuroblastoma; Neurons; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Transport; Transfection

2009
Association of mild and severely unstable alpha chain variants: the first observation of a compound heterozygote with Hb Setif [alpha94(G1)Asp-->Tyr (alpha2)] and Hb Agrinio [alpha29(B10)Leu-->Pro (alpha2)] in a Greek family.
    Hemoglobin, 2008, Volume: 32, Issue:6

    Topics: Adult; alpha-Globins; Amino Acid Substitution; Anemia; Aspartic Acid; Child; Child, Preschool; Female; Greece; Hemoglobins, Abnormal; Heterozygote; Humans; Leucine; Male; Middle Aged; Proline; Tyrosine

2008
Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.
    Biochemical and biophysical research communications, 2009, Jan-30, Volume: 379, Issue:1

    Topics: Adenylate Kinase; Crystallography, X-Ray; Humans; Leucine; Mutation; Proline; Protein Structure, Tertiary

2009
Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation.
    Neuromuscular disorders : NMD, 2009, Volume: 19, Issue:2

    Topics: Amino Acid Substitution; Cardiac Myosins; Cardiomyopathies; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Heart; Humans; Leucine; Middle Aged; Muscle Hypotonia; Muscle, Skeletal; Muscular Diseases; Mutation; Myocardium; Myosin Heavy Chains; Phenotype; Proline; Young Adult

2009
Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors.
    Journal of neurochemistry, 2009, Volume: 108, Issue:6

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cattle; Cell Line, Tumor; Green Fluorescent Proteins; Leucine; Models, Molecular; Mutagenesis; Mutation; Neuroblastoma; Oocytes; Proline; Protein Structure, Secondary; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Transfection; Xenopus

2009
Subcortical projections of the inferior parietal cortex (area 7) in the stump-tailed monkey.
    The Journal of comparative neurology, 1984, Apr-01, Volume: 224, Issue:2

    Topics: Animals; Brain Mapping; Leucine; Macaca; Neural Pathways; Parietal Lobe; Proline; Tritium

1984
Topographic organization of the ventral striatal efferent projections in the rhesus monkey: an anterograde tracing study.
    The Journal of comparative neurology, 1990, Mar-08, Volume: 293, Issue:2

    Topics: Animals; Autoradiography; Basal Ganglia; Efferent Pathways; Female; Globus Pallidus; Leucine; Macaca mulatta; Microinjections; Neural Pathways; Nucleus Accumbens; Phytohemagglutinins; Proline; Substantia Nigra; Tritium

1990
Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation.
    The international tinnitus journal, 2008, Volume: 14, Issue:2

    Topics: Alleles; Amino Acid Substitution; Base Sequence; Cerebellar Neoplasms; Cerebellopontine Angle; Chromosome Deletion; Codon; Diagnosis, Differential; DNA Mutational Analysis; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Neoplasms, Multiple Primary; Neuroma, Acoustic; Paraganglioma; Proline; Radiography; Radiosurgery; Succinate Dehydrogenase

2008
The role of non-synonymous NPY gene polymorphism in the nitric oxide production in HUVECs.
    Biochemical and biophysical research communications, 2009, Apr-17, Volume: 381, Issue:4

    Topics: Cells, Cultured; Endothelium, Vascular; Humans; Leucine; Neuropeptide Y; Nitric Oxide; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Proline; RNA, Messenger; Umbilical Veins

2009
Stereochemical preference in the reactions of N-protected L-amino acid 1-hydroxybenzotriazole esters with racemic amino acid derivatives.
    Protein and peptide letters, 2009, Volume: 16, Issue:3

    Topics: Amino Acids; Esters; Leucine; Proline; Stereoisomerism; Triazoles

2009
Toward an antitumor form of bovine pancreatic ribonuclease: the crystal structure of three noncovalent dimeric mutants.
    Biopolymers, 2009, Volume: 91, Issue:12

    Topics: Animals; Antineoplastic Agents; Catalytic Domain; Cattle; Crystallography, X-Ray; Cysteine; Endoribonucleases; Glycine; Isoenzymes; Leucine; Male; Models, Molecular; Mutation; Proline; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Recombinant Proteins; Ribonuclease, Pancreatic; Ribonucleases; Structure-Activity Relationship

2009
Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid chromatography with tandem mass spectrometric detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Apr-15, Volume: 877, Issue:11-12

    Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Cyclopropanes; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Polysorbates; Proline; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Surface-Active Agents; Tandem Mass Spectrometry; Viral Nonstructural Proteins

2009
Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation.
    Cell cycle (Georgetown, Tex.), 2009, May-01, Volume: 8, Issue:9

    Topics: Amino Acid Substitution; Breast Neoplasms; Caveolin 1; Cell Differentiation; Epithelial Cells; Female; Humans; Immunohistochemistry; Leucine; Mutation; Proline; Protein Transport

2009
Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population.
    Archives of oral biology, 2009, Volume: 54, Issue:6

    Topics: Adolescent; Adult; Asian People; Black or African American; Cephalometry; China; Cysteine; Exons; Female; Gene Deletion; Gene Frequency; Genotype; Haplotypes; Hispanic or Latino; Humans; Isoleucine; Japan; Korea; Leucine; Linkage Disequilibrium; Male; Mandible; Maxilla; Middle Aged; Phenylalanine; Polymorphism, Single Nucleotide; Proline; Protein Isoforms; Receptors, Somatotropin; Skull Base; Threonine; White People; Young Adult

2009
CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population.
    Molecular biology reports, 2010, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Aged; Case-Control Studies; Catalase; Female; Gene Frequency; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Middle Aged; Polymorphism, Single Nucleotide; Proline; Turkey; Young Adult

2010
Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety.
    Bioorganic & medicinal chemistry letters, 2009, Jul-15, Volume: 19, Issue:14

    Topics: Anticoagulants; Computer Simulation; Crystallography, X-Ray; Leucine; Proline; Protein Binding; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thrombin; Trypsin

2009
Metastable atom-activated dissociation mass spectrometry: leucine/isoleucine differentiation and ring cleavage of proline residues.
    Journal of mass spectrometry : JMS, 2009, Volume: 44, Issue:8

    Topics: Angiotensin II; Bradykinin; Cholecystokinin; Dipeptides; Fibrinopeptide B; Isoleucine; Leucine; Mass Spectrometry; Peptide Fragments; Phosphoproteins; Proline; Proteins; Substance P

2009
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
    Journal of neuropathology and experimental neurology, 2009, Volume: 68, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Endoplasmic Reticulum, Rough; Female; Humans; Leucine; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Mitochondria; Mutation; Proline; Qa-SNARE Proteins; Receptors, Peptide; Spinal Cord; Subcellular Fractions; tau Proteins

2009
Confirmation of allele HLA-A*3116 found in a family of a leukaemia patient with Caucasian and Caribbean origin.
    International journal of immunogenetics, 2009, Volume: 36, Issue:6

    Topics: Alleles; Amino Acid Substitution; Base Sequence; Black People; Caribbean Region; Female; HLA-A Antigens; Humans; Leucine; Male; Molecular Sequence Data; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proline; Sequence Homology, Nucleic Acid; White People

2009
Structural and mechanistic roles of three consecutive Pro residues of porcine NADH-cytochrome b(5) reductase for the binding of beta-NADH.
    Journal of bioscience and bioengineering, 2009, Volume: 108, Issue:4

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cytochrome-B(5) Reductase; Cytochromes b5; DNA Primers; Kinetics; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Proline; Protein Binding; Protein Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine

2009
Association between transforming growth factor beta1 polymorphisms and left ventricle hypertrophy in essential hypertensive subjects.
    Molecular and cellular biochemistry, 2010, Volume: 335, Issue:1-2

    Topics: Arginine; Asian People; Codon; Genotype; Humans; Hypertension; Hypertrophy, Left Ventricular; Leucine; Mutation; Polymorphism, Genetic; Proline; Transforming Growth Factor beta1

2010
Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme.
    Cancer research, 2009, Oct-15, Volume: 69, Issue:20

    Topics: Alanine; Alleles; Antioxidants; Breast Neoplasms; Codon; DNA Damage; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Lymphocytes; Mutagenesis; Polymorphism, Genetic; Proline; Selenium

2009
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Animals; Antiviral Agents; Area Under Curve; Cell Line; Cyclopropanes; Dogs; Genotype; Half-Life; Hepacivirus; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Macaca mulatta; Pan troglodytes; Proline; Protease Inhibitors; Rats; Recombinant Proteins; Replicon; Substrate Specificity; Sulfonamides; Viral Nonstructural Proteins

2010
AMINO ACID COMPOSITION OF HIGHLY PURIFIED VIRAL PARTICLES OF INFLUENZA A AND B.
    The Journal of experimental medicine, 1947, Jul-31, Volume: 86, Issue:2

    Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Humans; Influenza, Human; Isoleucine; Leucine; Lysine; Methionine; Orthomyxoviridae; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine; Virion

1947
Novel P2-P4 macrocyclic inhibitors of HCV NS3/4A protease by P3 succinamide fragment depeptidization strategy.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Binding Sites; Cell Line; Computer Simulation; Cyclopropanes; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Rats; Rats, Wistar; Succinates; Sulfonamides; Viral Nonstructural Proteins

2010
Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration.
    Neurobiology of aging, 2011, Volume: 32, Issue:10

    Topics: Adenosine Triphosphate; Age Factors; Animals; Apoptosis; Apoptosis Inducing Factor; Brain; Caspase 3; Electron Transport Complex I; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; In Situ Nick-End Labeling; Leucine; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Movement Disorders; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Oxidative Stress; Proline; Proton Pumps; Silver Staining; Statistics, Nonparametric; tau Proteins; Tauopathies

2011
Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1.
    Biochemical and biophysical research communications, 2010, Jan-01, Volume: 391, Issue:1

    Topics: Alzheimer Disease; Amino Acid Substitution; Apoptosis; Calcium; Calcium Channels; Endoplasmic Reticulum; HeLa Cells; Humans; Kinetics; Leucine; Membrane Glycoproteins; Mitochondria; Mutation; Proline

2010
CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 19, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Calcium Channels; Case-Control Studies; China; Female; Humans; Leucine; Male; Membrane Glycoproteins; Polymorphism, Genetic; Proline; Risk Factors

2010
Inverse correlation of thermal lability and conversion efficiency for five prion protein polymorphic variants.
    Biochemistry, 2010, Feb-23, Volume: 49, Issue:7

    Topics: Amino Acid Substitution; Animals; Cell-Free System; Deer; Genetic Predisposition to Disease; Genetic Variation; Immunity, Innate; Leucine; Mice; Peptide Fragments; Polymorphism, Genetic; Prion Diseases; Prions; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Stability; Sheep; Temperature

2010
Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
    Biochemistry, 2010, Mar-09, Volume: 49, Issue:9

    Topics: Acetic Acid; Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Caproates; Carboxylic Ester Hydrolases; Catalytic Domain; Crystallization; Crystallography, X-Ray; Diffusion; Esters; Hydrogen Peroxide; Hydrolysis; Lactones; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Pseudomonas fluorescens

2010
Glucocerebrosidase gene L444P mutation is a risk factor for Parkinson's disease in Chinese population.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Jun-15, Volume: 25, Issue:8

    Topics: Adult; Asian People; Case-Control Studies; Chi-Square Distribution; DNA Mutational Analysis; Female; Glucosylceramidase; Humans; Leucine; Male; Meta-Analysis as Topic; Middle Aged; Mutation; Parkinson Disease; Proline

2010
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
    Journal of medicinal chemistry, 2010, Mar-25, Volume: 53, Issue:6

    Topics: Animals; Area Under Curve; Carrier Proteins; Cyclopropanes; Dogs; Drug Discovery; Drug Evaluation, Preclinical; Hepacivirus; Indoles; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Macaca mulatta; Macrocyclic Compounds; Metabolic Clearance Rate; Models, Chemical; Molecular Structure; Pan troglodytes; Proline; Rats; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins; Viral Proteins

2010
L-Proline induces differentiation of ES cells: a novel role for an amino acid in the regulation of pluripotent cells in culture.
    American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:5

    Topics: Animals; Cell Line; Embryonic Stem Cells; Gene Expression Regulation; Glycine; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mice; Pluripotent Stem Cells; Proline; Protein Serine-Threonine Kinases; Signal Transduction; TOR Serine-Threonine Kinases

2010
CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 20, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channels; Female; Gene Frequency; Genes, Recessive; Genotype; Humans; Leucine; Male; Membrane Glycoproteins; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Proline; Spain

2010
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 20, Issue:1

    Topics: Age of Onset; Aged; Alzheimer Disease; Calcium Channels; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Italy; Leucine; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Proline

2010
Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Jun-15, Volume: 25, Issue:8

    Topics: Child, Preschool; Dihydroxyphenylalanine; DNA Mutational Analysis; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Leucine; Metabolic Diseases; Methoxyhydroxyphenylglycol; Mutation; Proline; Tyrosine; Tyrosine 3-Monooxygenase; Young Adult

2010
Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Antiviral Agents; Cyclopropanes; Dipeptides; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance, Viral; Genotype; Hepacivirus; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Kinetics; Leucine; Mutation; Proline; Protease Inhibitors; Recombinant Proteins; Replicon; Sulfones; Urea; Viral Nonstructural Proteins

2010
Folding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways.
    Biochemistry, 2010, May-18, Volume: 49, Issue:19

    Topics: beta-Lactamases; Circular Dichroism; Kinetics; Leucine; Models, Molecular; Proline; Protein Conformation; Protein Folding; Recombinant Proteins; Stereoisomerism; Thermodynamics

2010
Efficient asymmetric organocatalytic formation of erythrose and threose under aqueous conditions.
    Chemical communications (Cambridge, England), 2010, Jul-14, Volume: 46, Issue:26

    Topics: Alanine; Catalysis; Leucine; Prebiotics; Proline; Stereoisomerism; Tetroses; Water

2010
Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:11

    Topics: Glutamine; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Interleukin-1beta; Interleukin-8; Leucine; Models, Biological; NF-kappa B; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Necrosis Factor-alpha

2010
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
    Brain research, 2010, Aug-06, Volume: 1347

    Topics: Animals; Basigin; Brain; Choline O-Acetyltransferase; Cholinergic Agents; Gene Expression Regulation; Interneurons; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proline; tau Proteins; Tauopathies

2010
Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation.
    Neuromuscular disorders : NMD, 2010, Volume: 20, Issue:7

    Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Adolescent; Adult; Apoptosis Regulatory Proteins; Child; DNA Mutational Analysis; Family Health; Female; Genotype; Humans; Leucine; Male; Microscopy, Electron, Scanning; Muscular Diseases; Mutation; Phenotype; Proline; Sural Nerve; Young Adult

2010
Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).
    Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Hepacivirus; Humans; Leucine; Male; Microsomes, Liver; Oligopeptides; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Replicon; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins

2010
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication

2010
Using temperature to optimize resolution and reduce analysis times for bioanalytical diastereomer LC-MS/MS separations.
    Journal of pharmaceutical and biomedical analysis, 2011, Jan-05, Volume: 54, Issue:1

    Topics: Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclopropanes; Dipeptides; Humans; Leucine; Proline; Reproducibility of Results; Stereoisomerism; Sulfones; Tandem Mass Spectrometry; Temperature; Time Factors; Urea

2011
Propensities of aromatic amino acids versus leucine and proline to induce residual structure in the denatured-state ensemble of iso-1-cytochrome c.
    Journal of molecular biology, 2010, Nov-05, Volume: 403, Issue:4

    Topics: Amino Acid Substitution; Amino Acids, Aromatic; Cytochromes c; Kinetics; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Stability; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Static Electricity; Thermodynamics

2010
Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Antiviral Agents; Cell Line, Tumor; Cyclopropanes; Hepacivirus; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Molecular Structure; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Sulfonamides

2010
Identification of metastable states in peptide's dynamics.
    The Journal of chemical physics, 2010, Oct-28, Volume: 133, Issue:16

    Topics: Alanine; Leucine; Markov Chains; Molecular Dynamics Simulation; Oligopeptides; Proline; Protein Conformation; Valine

2010
Manganese superoxide dismutase dimorphism relationship with severity and prognosis in cardiogenic shock due to dilated cardiomyopathy.
    Free radical research, 2011, Volume: 45, Issue:4

    Topics: Alanine; Alleles; Biomarkers; Cardiomyopathy, Dilated; Cohort Studies; Female; Genetic Association Studies; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Middle Aged; Natriuretic Peptide, Brain; Oxidative Stress; Polymorphism, Genetic; Prognosis; Proline; Reactive Oxygen Species; Severity of Illness Index; Shock, Cardiogenic; Superoxide Dismutase; Valine

2011
Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:2

    Topics: Animals; Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Pan troglodytes; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Tubercidin; Viral Load; Viral Nonstructural Proteins

2011
Pro198Leu polymorphism of GPx-1 gene and activity of erythrocytic glutathione peroxidase and lipid peroxidation products.
    Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:6

    Topics: Base Sequence; DNA Primers; Erythrocytes; Glutathione Peroxidase; Humans; Leucine; Lipid Peroxidation; Male; Polymorphism, Genetic; Proline

2010
Lower limb areflexia without central and peripheral conduction abnormalities is highly suggestive of Gerstmann-Sträussler-Scheinker disease Pro102Leu.
    Journal of the neurological sciences, 2011, Mar-15, Volume: 302, Issue:1-2

    Topics: Adult; Brain; Electroencephalography; Electrophysiological Phenomena; Evoked Potentials, Motor; Evoked Potentials, Somatosensory; Family; Female; Gerstmann-Straussler-Scheinker Disease; Humans; Italy; Leucine; Lower Extremity; Magnetic Resonance Imaging; Male; Middle Aged; Neural Conduction; Neurologic Examination; Prions; Proline; Reflex, Abnormal

2011
Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations.
    Journal of dental research, 2011, Volume: 90, Issue:4

    Topics: Adolescent; Anodontia; Arginine; Child; Child, Preschool; Cleft Lip; Cleft Palate; Cohort Studies; Conserved Sequence; DNA-Binding Proteins; Exons; Female; Genetic Variation; Glutamine; Humans; Labial Frenum; Leucine; Male; Mutation, Missense; Phenotype; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Serine; T-Box Domain Proteins; Tongue Diseases; Transcription, Genetic; Tryptophan; Tyrosine

2011
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
    The Journal of biological chemistry, 2011, Apr-01, Volume: 286, Issue:13

    Topics: Aminoisobutyric Acids; Carrier Proteins; Catalytic Domain; Clinical Trials, Phase I as Topic; Crystallography, X-Ray; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Proline; Protease Inhibitors; Protein Binding; Quinolines; Thiazoles; Viral Nonstructural Proteins

2011
Amino acid-induced gene expression profiling in clonal β-cell line INS-1E cells.
    Diabetes/metabolism research and reviews, 2011, Volume: 27, Issue:2

    Topics: Animals; Biomarkers; Cells, Cultured; Gene Expression Profiling; Homocysteine; Insulin-Secreting Cells; Leucine; Oligonucleotide Array Sequence Analysis; Proline; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2011
TGF-β1 gene polymorphism in renal transplant patients with and without gingival overgrowth.
    Oral diseases, 2011, Volume: 17, Issue:4

    Topics: Adenine; Adolescent; Adult; Aged; Arginine; Case-Control Studies; Codon; Cyclosporine; Cytosine; Female; Gene Frequency; Genotype; Gingival Overgrowth; Guanine; Haplotypes; Humans; Immunosuppressive Agents; Kidney Transplantation; Leucine; Male; Middle Aged; Polymorphism, Single Nucleotide; Proline; Promoter Regions, Genetic; Thymine; Transforming Growth Factor beta1; Young Adult

2011
CLRN1 mutations cause nonsyndromic retinitis pigmentosa.
    Ophthalmology, 2011, Volume: 118, Issue:7

    Topics: Adult; Audiometry, Pure-Tone; Consanguinity; DNA; Electroretinography; Fundus Oculi; Genes, Recessive; Genetic Linkage; Humans; Intracellular Space; Leucine; Membrane Proteins; Microarray Analysis; Mutation, Missense; Night Blindness; Polymorphism, Single Nucleotide; Proline; Retinitis Pigmentosa; Tissue Distribution; Tryptophan; Young Adult

2011
Metabolism of select amino acids in bacteria from the pig small intestine.
    Amino acids, 2012, Volume: 42, Issue:5

    Topics: Animals; Arginine; Bacteria; Digestion; Humans; Intestine, Small; Leucine; Lysine; Methionine; Proline; Swine; Threonine

2012
Proteomic and metabolomic analysis of H2O2-induced premature senescent human mesenchymal stem cells.
    Experimental gerontology, 2011, Volume: 46, Issue:6

    Topics: Annexin A2; Cell Proliferation; Cells, Cultured; Cellular Senescence; Choline; Dose-Response Relationship, Drug; Glycine; Humans; Hydrogen Peroxide; Leucine; Mesenchymal Stem Cells; Metabolomics; Proline; Proteomics; Reactive Oxygen Species

2011
Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2011, Volume: 118, Issue:5

    Topics: Age Factors; Animals; Calcium-Binding Proteins; Female; Gene Expression Regulation; Genotype; Hippocampus; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Proline; Secretagogins; tau Proteins

2011
Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis.
    Bioanalysis, 2011, Volume: 3, Issue:7

    Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cyclopropanes; Dipeptides; Humans; Leucine; Lysophosphatidylcholines; Phosphatidylcholines; Proline; Stereoisomerism; Sulfones; Tandem Mass Spectrometry; Technology, Pharmaceutical; Temperature; Urea

2011
Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization.
    Biochemical and biophysical research communications, 2011, May-20, Volume: 408, Issue:4

    Topics: Animals; Calcium-Binding Proteins; Catalysis; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Isomerism; Leucine; Mice; Molecular Sequence Data; Mutation; Peptidylprolyl Isomerase; Proline; Protein Conformation; Substrate Specificity; Tacrolimus Binding Proteins

2011
Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulations.
    The journal of physical chemistry. A, 2011, Sep-01, Volume: 115, Issue:34

    Topics: Binding Sites; Chemistry, Physical; Computer Simulation; Humans; Leucine; Models, Molecular; Peptide Fragments; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proto-Oncogene Proteins c-mdm2; Serine; Solvents; Spectrum Analysis, Raman; Tumor Suppressor Protein p53

2011
Precision and accuracy in the quantitative analysis of biological samples by accelerator mass spectrometry: application in microdose absolute bioavailability studies.
    Analytical chemistry, 2011, Jul-15, Volume: 83, Issue:14

    Topics: Administration, Oral; Adult; Antiviral Agents; Calibration; Chromatography, Liquid; Cyclopropanes; Dipeptides; Humans; Injections, Intravenous; Leucine; Male; Middle Aged; Proline; Reproducibility of Results; Sensitivity and Specificity; Sulfones; Tandem Mass Spectrometry; Urea; Young Adult

2011
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
    Journal of neuropathology and experimental neurology, 2011, Volume: 70, Issue:7

    Topics: Animals; Animals, Genetically Modified; Cell Count; Cytoskeletal Proteins; Disease Models, Animal; Doxycycline; Environment; Gene Expression Regulation; Hippocampus; Indoles; Leucine; Mice; Mutation; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Proline; RNA, Messenger; tau Proteins; Tauopathies

2011
Functional characterization of the P1059L mutation in the inositol 1,4,5-trisphosphate receptor type 1 identified in a Japanese SCA15 family.
    Biochemical and biophysical research communications, 2011, Jul-15, Volume: 410, Issue:4

    Topics: Amino Acid Substitution; Asian People; Calcium; Cell Line; Humans; Inositol 1,4,5-Trisphosphate Receptors; Leucine; Pedigree; Proline; Protein Isoforms; Spinocerebellar Ataxias

2011
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.
    Gastroenterology, 2011, Volume: 141, Issue:3

    Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Molecular Sequence Data; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins

2011
Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
    Journal of proteomics, 2011, Oct-19, Volume: 74, Issue:11

    Topics: Age Factors; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Brain Chemistry; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leucine; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Presenilin-1; Proline; Protein Carbonylation; Protein Structure, Tertiary; Proteomics

2011
Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.
    The Journal of organic chemistry, 2011, Oct-07, Volume: 76, Issue:19

    Topics: Catalysis; Chemistry Techniques, Synthetic; Cyclization; Cyclopropanes; Hydrogenation; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Palladium; Proline; Sulfonamides

2011
Report of two Chinese patients suffering from CLCN7-related osteopetrosis and root dysplasia.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2012, Volume: 40, Issue:5

    Topics: Adult; Arginine; Bone Density; China; Chloride Channels; Dentofacial Deformities; Genes, Recessive; Genetic Variation; Heterozygote; Homozygote; Humans; Leucine; Male; Osteomyelitis; Osteopetrosis; Osteosclerosis; Phenotype; Point Mutation; Proline; Tooth Abnormalities; Tooth Root; Tooth, Unerupted; Tryptophan

2012
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:2

    Topics: Absorption; Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Caco-2 Cells; Dogs; Drug Evaluation, Preclinical; Hepacivirus; Humans; Leucine; Macaca mulatta; Male; Microsomes, Liver; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution; Viral Nonstructural Proteins

2012
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Crystallography, X-Ray; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Interferon-alpha; Kinetics; Leucine; Mutagenesis, Site-Directed; Mutation Rate; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Replicon; Thiazoles; Viral Nonstructural Proteins

2012
Interferon-free treatment regimens for hepatitis C: are we there yet?
    Gastroenterology, 2011, Volume: 141, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Oligopeptides; Proline; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; Thiazoles

2011
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy.
    Neurobiology of aging, 2012, Volume: 33, Issue:9

    Topics: Analysis of Variance; Animals; Antioxidants; Brain; Disease Models, Animal; Grape Seed Extract; Humans; Leucine; Male; Mice; Mice, Transgenic; Molecular Weight; Mutation; Polyphenols; Proline; Psychomotor Performance; Spinal Cord; tau Proteins; Tauopathies

2012
Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Dec-07, Volume: 31, Issue:49

    Topics: Age Factors; Animals; Bacterial Proteins; Brain; Cells, Cultured; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Female; Humans; Leucine; Luminescent Proteins; Male; Mice; Mice, Transgenic; Neurons; Phosphorylation; Proline; Synaptosomes; tau Proteins

2011
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
    Neurobiology of disease, 2012, Volume: 45, Issue:3

    Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leucine; Male; Mutation; Neuroblastoma; Okadaic Acid; Pentylenetetrazole; Phosphorylation; Proline; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Selenic Acid; Selenium Compounds; tau Proteins; Time Factors; Transfection

2012
[Determination of amino acid contents in cottonseeds using near infrared reflectance spectroscopy].
    Guang pu xue yu guang pu fen xi = Guang pu, 2011, Volume: 31, Issue:10

    Topics: Alanine; Amino Acids; Arginine; Asparagine; Calibration; Cottonseed Oil; Cystine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Spectroscopy, Near-Infrared; Threonine; Tyrosine; Valine

2011
Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses.
    Combinatorial chemistry & high throughput screening, 2012, Volume: 15, Issue:6

    Topics: Antiviral Agents; Carrier Proteins; Cyclopropanes; Dipeptides; Drug Design; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Models, Molecular; Proline; Quantitative Structure-Activity Relationship; Sulfones; Urea; Viral Nonstructural Proteins

2012
High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.
    Gene, 2012, Mar-15, Volume: 496, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Case-Control Studies; Coronary Artery Disease; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetics, Population; Humans; Iran; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Single Nucleotide; Prevalence; Proline; Young Adult

2012
Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.
    The Journal of organic chemistry, 2012, Apr-20, Volume: 77, Issue:8

    Topics: Catalysis; Cyclization; Cyclopropanes; Hepacivirus; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Molecular Structure; Proline; Protease Inhibitors; Ruthenium; Sulfonamides

2012
Enantiopure synthesis of side chain-modified α-amino acids and 5-cis-alkylprolines.
    The Journal of organic chemistry, 2012, Jun-15, Volume: 77, Issue:12

    Topics: Amino Acids; Aminolevulinic Acid; Leucine; Molecular Structure; Norleucine; Proline; Stereoisomerism

2012
Glutathione peroxidase 1 Pro198Leu polymorphism in Brazilian Alzheimer's disease patients: relations to the enzyme activity and to selenium status.
    Journal of nutrigenetics and nutrigenomics, 2012, Volume: 5, Issue:2

    Topics: Aged; Alzheimer Disease; Base Sequence; Brazil; Case-Control Studies; DNA Primers; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Selenium

2012
Genetic association between obstructive bronchitis and enzymes of oxidative stress.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:12

    Topics: Adult; Arginine; Aryldialkylphosphatase; Bronchitis; Catechol O-Methyltransferase; Chi-Square Distribution; Child; Cohort Studies; Epoxide Hydrolases; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Germany; Histidine; Humans; Leucine; Lung Diseases, Obstructive; Male; Methionine; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Proline; Prospective Studies; Risk Factors; Serine; Smoking; Valine

2012
Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.
    Immunogenetics, 2012, Volume: 64, Issue:12

    Topics: Asian People; Cell Line; Exons; Humans; Jurkat Cells; Leucine; Phosphorylation; Polymorphism, Genetic; Proline; Receptors, IgG; Signal Transduction; Tyrosine

2012
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
    PLoS pathogens, 2012, Volume: 8, Issue:7

    Topics: Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins

2012
The phosphoproteome of the adenovirus type 2 virion.
    Virology, 2012, Nov-10, Volume: 433, Issue:1

    Topics: Adenoviridae; Amino Acid Sequence; Chromatography, Liquid; HeLa Cells; Humans; Leucine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proline; Proteome; Proteomics; Viral Proteins; Virion

2012
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
    Journal of neuroinflammation, 2012, Sep-18, Volume: 9

    Topics: Animals; Brain; CD59 Antigens; Disease Models, Animal; Green Fluorescent Proteins; Humans; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Phosphorylation; Proline; Receptors, Complement; Signal Transduction; tau Proteins; Tauopathies

2012
Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification.
    Neurology, 2013, Jan-08, Volume: 80, Issue:2

    Topics: Adult; Aged; Amino Acid Substitution; Arginine; Basal Ganglia Diseases; Calcinosis; Child; Databases, Genetic; Exome; Female; Humans; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neurologic Examination; Parkinson Disease; Pedigree; Polymerase Chain Reaction; Proline; Receptor, Platelet-Derived Growth Factor beta; Tomography, X-Ray Computed; Tryptophan

2013
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
    Blood, 2013, Mar-14, Volume: 121, Issue:11

    Topics: Adult; Aged; Alleles; Amino Acid Substitution; B-Lymphocytes; Base Sequence; Case-Control Studies; Cell Transformation, Neoplastic; DNA Mutational Analysis; Humans; Immunoglobulin M; Leucine; Lymphoproliferative Disorders; Male; Middle Aged; Molecular Sequence Data; Monoclonal Gammopathy of Undetermined Significance; Myeloid Differentiation Factor 88; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Waldenstrom Macroglobulinemia

2013
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms.
    Blood, 2013, Mar-28, Volume: 121, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Case-Control Studies; Female; Humans; Immunoglobulin M; Leucine; Lymphoma; Lymphoproliferative Disorders; Male; Middle Aged; Monoclonal Gammopathy of Undetermined Significance; Mutation, Missense; Myeloid Differentiation Factor 88; Prevalence; Proline; Waldenstrom Macroglobulinemia

2013
PlA(1)/PlA(2) polymorphism does not influence response to Gp IIb-IIIa inhibitors in patients undergoing coronary angioplasty.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2013, Volume: 24, Issue:4

    Topics: Abciximab; Aged; Amino Acid Substitution; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Blood Platelets; Drug Administration Schedule; Eptifibatide; Female; Humans; Immunoglobulin Fab Fragments; Leucine; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Proline; Tirofiban; Treatment Outcome; Tyrosine

2013
The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Mar-13, Volume: 33, Issue:11

    Topics: Animals; Brain Mapping; Fluorescent Dyes; Imaging, Three-Dimensional; Leucine; Macaca fascicularis; Macaca nemestrina; Male; Neural Pathways; Prefrontal Cortex; Proline; Subthalamic Nucleus; Tritium

2013
Application of capillary electrophoresis coupling with electrochemiluminescence detection to estimate activity of leucine aminopeptidas.
    Biomedical chromatography : BMC, 2013, Volume: 27, Issue:7

    Topics: Case-Control Studies; Cholestasis; Electrophoresis, Capillary; Enzyme Stability; Female; Hepatitis; Humans; Hydrogen-Ion Concentration; Leucine; Leucyl Aminopeptidase; Limit of Detection; Liver Neoplasms; Luminescent Measurements; Male; Proline; Reproducibility of Results; Signal-To-Noise Ratio

2013
The presenilin 1 P264L mutation presenting as non-fluent/agrammatic primary progressive aphasia.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:2

    Topics: Female; Fluorodeoxyglucose F18; Hippocampus; Humans; Leucine; Magnetic Resonance Imaging; Middle Aged; Mutation; Positron-Emission Tomography; Presenilin-1; Primary Progressive Nonfluent Aphasia; Proline

2013
Quantitative analysis of interdental Gingiva in patients with chronic periodontitis and transforming growth factor-β1 29C/T gene polymorphisms.
    Journal of periodontology, 2014, Volume: 85, Issue:2

    Topics: Adult; Alleles; Azo Compounds; Case-Control Studies; Chronic Periodontitis; Collagen; Coloring Agents; Connective Tissue; Cytosine; Disease Progression; Eosine Yellowish-(YS); Epithelium; Extracellular Matrix; Female; Genotype; Gingiva; Humans; Leucine; Male; Methyl Green; Microvessels; Middle Aged; Polymorphism, Genetic; Proline; Thymine; Transforming Growth Factor beta1

2014
Deracemization of amino acids by partial sublimation and via homochiral self-organization.
    Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2013, Volume: 43, Issue:2

    Topics: Alanine; Amino Acids; Leucine; Proline; Stereoisomerism; Valine

2013
Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders.
    Bosnian journal of basic medical sciences, 2013, Volume: 13, Issue:2

    Topics: Adult; Alanine; Alleles; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Genotype; Glutathione Peroxidase; Humans; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Real-Time Polymerase Chain Reaction; Superoxide Dismutase; Valine

2013
Computational study on the drug resistance mechanism against HCV NS3/4A protease inhibitors vaniprevir and MK-5172 by the combination use of molecular dynamics simulation, residue interaction network, and substrate envelope analysis.
    Journal of chemical information and modeling, 2014, Feb-24, Volume: 54, Issue:2

    Topics: Amides; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Protease Inhibitors; Protein Conformation; Quinoxalines; Sulfonamides; Thermodynamics; Viral Nonstructural Proteins

2014
Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry.
    Biochemistry, 2013, Aug-13, Volume: 52, Issue:32

    Topics: Binding Sites; Deuterium Exchange Measurement; Fibrin; Fibrinogen; Humans; Leucine; Mass Spectrometry; Models, Molecular; Peptide Fragments; Proline; Protein Conformation; Protein Folding

2013
Type II antithrombin deficiency caused by a founder mutation Pro73Leu in the Finnish population: clinical picture.
    Journal of thrombosis and haemostasis : JTH, 2013, Volume: 11, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antithrombins; Base Sequence; Cohort Studies; DNA Primers; Female; Finland; Founder Effect; Humans; Leucine; Male; Middle Aged; Mutation; Proline; Young Adult

2013
Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of L-prolyl-L-leucyl-glycinamide (PLG) modified in the L-proline or L-proline and L-leucine scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Allosteric Regulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Leucine; Models, Molecular; Molecular Conformation; Oligopeptides; Proline; Receptors, Dopamine D2; Structure-Activity Relationship

2013
Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 38, Issue:3

    Topics: Analysis of Variance; Animals; Antibodies; Brain; Disease Models, Animal; Gene Expression Regulation; Humans; Leucine; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Molecular Weight; Mutation; Oligodendroglia; Proline; Rats; tau Proteins; Tauopathies

2014
Function of the head-tail junction in the activity of myosin II.
    Biochemical and biophysical research communications, 2013, Nov-01, Volume: 440, Issue:4

    Topics: Actins; Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; Chickens; Conserved Sequence; Leucine; Mutation; Proline; Smooth Muscle Myosins

2013
Baseline hepatitis C virus (HCV) NS3 polymorphisms and their impact on treatment response in clinical studies of the HCV NS3 protease inhibitor faldaprevir.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:2

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins

2014
Phenotypic expression of the p.Leu1077Pro CFTR mutation in Sicilian cystic fibrosis patients.
    BMC research notes, 2013, Nov-13, Volume: 6

    Topics: Child; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Gene Expression Regulation; Genotype; Heterozygote; Humans; Leucine; Male; Mutation; Phenotype; Proline; Pseudomonas aeruginosa; Pseudomonas Infections; Sicily; Young Adult

2013
Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Drug Stability; Drug Storage; Feces; Female; Hepatocytes; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Leucine; Male; Metabolic Clearance Rate; Microsomes; Oligopeptides; Proline; Protein Binding; Quinolines; Thiazoles

2014
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Stability; Female; Fibroblasts; Glucuronides; Hepatocytes; Humans; Kinetics; Leucine; Liver; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Organic Anion Transporters; Proline; Quinolines; Sodium; Thiazoles

2014
Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Bile; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Dose-Response Relationship, Drug; Drug Stability; Fibroblasts; Glucuronides; Hepacivirus; Hepatocytes; Leucine; Liver; Male; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Proline; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles

2014
Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Volume: 58, Issue:7

    Topics: Aminoisobutyric Acids; Anti-HIV Agents; Antiviral Agents; Carbamates; Developing Countries; Drug Industry; Drug Therapy, Combination; Health Services Accessibility; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine

2014
IgG-lymphoplasmacytic lymphoma following polycythemia vera: JAK2 V617F and MYD88 L265P mutations separated in the same house.
    Annals of hematology, 2014, Volume: 93, Issue:9

    Topics: Aged; Amino Acid Substitution; Humans; Immunoglobulin G; Janus Kinase 2; Leucine; Male; Mutation, Missense; Myeloid Differentiation Factor 88; Phenylalanine; Polycythemia Vera; Proline; Valine; Waldenstrom Macroglobulinemia

2014
Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up.
    Journal of endocrinological investigation, 2014, Volume: 37, Issue:4

    Topics: Aged; Amino Acids; Arginine; Betaine; Body Mass Index; Fasting; Female; Humans; Hypertriglyceridemia; Isoleucine; Leucine; Male; Middle Aged; Odds Ratio; Phenylalanine; Proline; Risk Factors; ROC Curve; Triglycerides; Valine

2014
Platelet glycoprotein IIIa gene polymorphism (Leu33Pro) and aspirin resistance in a very elderly Chinese population.
    Genetic testing and molecular biomarkers, 2014, Volume: 18, Issue:6

    Topics: Aged; Aged, 80 and over; Aspirin; Base Sequence; CD36 Antigens; DNA Primers; Drug Resistance; Female; Humans; Leucine; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline

2014
Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy.
    Alimentary pharmacology & therapeutics, 2014, Volume: 39, Issue:12

    Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Interferons; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate

2014
Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:11

    Topics: Administration, Oral; Aminoisobutyric Acids; Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Injections, Intravenous; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles; Urine

2014
Novel complex disease allele mutations in cleidocranial dysplasia patients.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:10

    Topics: Adenine; Alleles; Amino Acid Sequence; Asparagine; Aspartic Acid; Case-Control Studies; Cleidocranial Dysplasia; Conserved Sequence; Core Binding Factor Alpha 1 Subunit; Cytosine; Exons; Female; Guanine; Humans; Leucine; Male; Mutation, Missense; Proline; Protein Conformation; Thymine; Tooth, Supernumerary

2014
A case of successful treatment with telaprevir-based triple therapy for hepatitis C infection after treatment failure with vaniprevir-based triple therapy.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2014, Volume: 20, Issue:9

    Topics: Aged; Antiviral Agents; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Oligopeptides; Proline; Sulfonamides; Treatment Failure

2014
Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion.
    Systems biology in reproductive medicine, 2014, Volume: 60, Issue:5

    Topics: Abortion, Spontaneous; Adolescent; Adult; Base Sequence; Catalase; DNA Primers; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Polymorphism, Genetic; Proline; Young Adult

2014
Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.
    The Journal of biological chemistry, 2014, Sep-05, Volume: 289, Issue:36

    Topics: Ammonium Compounds; Glutamine; Immunoblotting; Leucine; Methionine Sulfoximine; Monomeric GTP-Binding Proteins; Mutation; Nitrogen; Phosphorylation; Proline; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors

2014
A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Jul-30, Volume: 34, Issue:31

    Topics: Acetylcholine; Animals; Animals, Genetically Modified; Botulinum Toxins, Type A; Green Fluorescent Proteins; Humans; In Vitro Techniques; Larva; Leucine; Locomotion; Miniature Postsynaptic Potentials; Muscle, Skeletal; Mutation; Neuromuscular Junction; Patch-Clamp Techniques; Phenotype; Proline; Receptors, Cholinergic; Swimming; Zebrafish

2014
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
    Behavioural brain research, 2014, Dec-15, Volume: 275

    Topics: Acoustic Stimulation; Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inhibition, Psychological; Leucine; Mice; Mice, Transgenic; Mutation; Phenotype; Proline; Psychotic Disorders; Reflex, Startle; tau Proteins

2014
Computational study on the molecular mechanisms of drug resistance of Narlaprevir due to V36M, R155K, V36M+R155K, T54A, and A156T mutations of HCV NS3/4A protease.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2014, Volume: 92, Issue:5

    Topics: Antiviral Agents; Cyclopropanes; Dipeptides; Drug Resistance, Viral; Genes, Viral; Hepacivirus; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Sulfones; Urea; Viral Nonstructural Proteins

2014
Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Nov-18, Volume: 111, Issue:46

    Topics: Algorithms; Animals; Axonal Transport; Axons; Body Water; Connectome; Contrast Media; Diffusion; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Gadolinium DTPA; Leucine; Macaca mulatta; Male; Models, Neurological; Motor Cortex; Occipital Lobe; Proline; Research Design; ROC Curve; Sensitivity and Specificity; Tritium; White Matter

2014
A novel MYH7 Leu1453pro mutation resulting in Laing distal myopathy in an Irish family.
    Neuromuscular disorders : NMD, 2015, Volume: 25, Issue:2

    Topics: Adult; Aged; Brain; Cardiac Myosins; Creatine Kinase; Distal Myopathies; Electromyography; Epilepsy; Family Health; Female; Humans; Ireland; Leucine; Male; Middle Aged; Muscle, Skeletal; Mutation; Myosin Heavy Chains; Proline

2015
One-step molecular detection of the MYD88 L265P mutation by unlabeled probe genotyping analysis.
    Molecular and cellular probes, 2015, Volume: 29, Issue:1

    Topics: Antigens, Differentiation; Genotype; Humans; Leucine; Molecular Diagnostic Techniques; Mutation; Oligonucleotide Probes; Proline; Reproducibility of Results; Sequence Analysis, DNA; Waldenstrom Macroglobulinemia

2015
Influence of the GPX1 gene polymorphism to aerobic capacity and efficiency of glutathione supplementation in athletes.
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:2

    Topics: Adult; Alleles; Antioxidants; Athletes; Case-Control Studies; Female; Gene Expression; Gene Frequency; Genotype; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heterozygote; Homozygote; Humans; Injections, Intramuscular; Leucine; Male; Oxygen Consumption; Physical Endurance; Polymorphism, Single Nucleotide; Proline

2014
Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient.
    Journal of neurology, 2015, Volume: 262, Issue:1

    Topics: Adult; Amyloid Neuropathies, Familial; Humans; Leucine; Male; Meninges; Mutation; Nigeria; Proline

2015
The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.
    Blood, 2015, Feb-12, Volume: 125, Issue:7

    Topics: Adult; Amino Acid Substitution; Cells, Cultured; Child; Child, Preschool; Family; Female; HeLa Cells; Homeostasis; Humans; Leucine; Male; Mutation, Missense; Pedigree; Proline; Receptors, Thrombopoietin; Signal Transduction; Thrombocytopenia; Thrombocytosis; Thrombopoietin; Young Adult

2015
Chemiluminescence Detection of Serine, Proline, Glycine, Asparagine, Leucine, and Histidine by Using Corresponding Aminoacyl-tRNA Synthetases as Recognition Elements.
    Applied biochemistry and biotechnology, 2015, Volume: 176, Issue:4

    Topics: Amino Acyl-tRNA Synthetases; Asparagine; Biological Assay; Buffers; Glycine; Histidine; Humans; Leucine; Luminescence; Luminescent Measurements; Luminol; Proline; Sensitivity and Specificity; Serine; Solutions; Water

2015
Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia.
    Molecular genetics and metabolism, 2015, Volume: 115, Issue:4

    Topics: Alkaline Phosphatase; Animals; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetulus; Humans; Hypophosphatasia; Leucine; Mutation; Phenotype; Proline; Tooth Demineralization

2015
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake.
    HIV medicine, 2015, Volume: 16, Issue:10

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cohort Studies; Female; Hepatitis C, Chronic; HIV Infections; Humans; Leucine; Male; Middle Aged; Oligopeptides; Patient Acceptance of Health Care; Proline; Prospective Studies; Protease Inhibitors; Quinolines; RNA, Viral; Switzerland; Thiazoles; Viral Load

2015
Probable novel PSEN2 Pro123Leu mutation in a Chinese Han family of Alzheimer's disease.
    Neurobiology of aging, 2015, Volume: 36, Issue:12

    Topics: Alzheimer Disease; Amino Acid Substitution; Asian People; Codon; Diagnostic Imaging; Exons; Genetic Association Studies; Humans; Leucine; Mutation, Missense; Presenilin-2; Proline

2015
Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.
    Virus research, 2016, Feb-02, Volume: 213

    Topics: Animals; Antiviral Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Gene Expression Profiling; Hepacivirus; Hepatitis C; Hepatocytes; High-Throughput Nucleotide Sequencing; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mice; Mice, Transgenic; Mutation, Missense; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Virus Replication

2016
The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum.
    Journal of cellular physiology, 2016, Volume: 231, Issue:7

    Topics: 3T3 Cells; Amino Acid Motifs; Animals; Dentin; Endoplasmic Reticulum; Extracellular Matrix Proteins; Golgi Apparatus; Humans; Leucine; Mice; Osteoblasts; Proline; Valine

2016
The proline-rich region of glyceraldehyde-3-phosphate dehydrogenase from human sperm may bind SH3 domains, as revealed by a bioinformatic study of low-complexity protein segments.
    Molecular reproduction and development, 2016, Volume: 83, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Cell Adhesion Molecules; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Leucine; Male; Mutation, Missense; Proline; Protein-Tyrosine Kinases; Signal Transduction; Sperm Tail; src Homology Domains

2016
From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Adult; Aged; Antioxidants; Case-Control Studies; Female; Gene Expression Regulation, Leukemic; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Isoleucine; Leucine; Leukemia, Myeloid, Acute; Male; Middle Aged; Multivariate Analysis; Mutation; Polymorphism, Genetic; Proline; Reactive Oxygen Species; Risk; Romania; Superoxide Dismutase; Valine

2016
[Vaniprevir with pegylated interferon and ribavirin in treatment for chronic hepatitis C].
    Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73 Suppl 9

    Topics: Clinical Trials as Topic; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Indoles; Interferons; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Ribavirin; Sulfonamides

2015
Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their differential responses to cortisol and aldosterone.
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 159

    Topics: Aldosterone; Amino Acid Substitution; Binding Sites; Conserved Sequence; Dexamethasone; Glutamine; HEK293 Cells; Humans; Hydrocortisone; Hydrogen Bonding; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Binding; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Serine; Structural Homology, Protein; Transcriptional Activation

2016
Association Between the Transforming Growth Factor Beta 1 Gene Polymorphisms and Turkish Patients with Nonsyndromic Cleft Lip With/Without Cleft Palate.
    Genetic testing and molecular biomarkers, 2016, Volume: 20, Issue:5

    Topics: Amino Acid Substitution; Arginine; Case-Control Studies; Child; Child, Preschool; Cleft Lip; Cleft Palate; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Leucine; Polymorphism, Single Nucleotide; Proline; Transforming Growth Factor beta1; Turkey

2016
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
    Science (New York, N.Y.), 2016, Mar-11, Volume: 351, Issue:6278

    Topics: Aged; Amino Acid Substitution; Animals; Cholesterol, HDL; Coronary Disease; DNA Mutational Analysis; Female; Genetic Variation; Heterozygote; Homozygote; Humans; Leucine; Male; Mice; Middle Aged; Proline; Protein Processing, Post-Translational; Risk; Scavenger Receptors, Class B

2016
Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.
    Leukemia & lymphoma, 2016, Volume: 57, Issue:11

    Topics: Adenine; Amino Acid Substitution; Female; Humans; Immunoglobulin G; Leucine; Mutation, Missense; Myeloid Differentiation Factor 88; Piperidines; Proline; Pyrazoles; Pyrimidines; Treatment Outcome; Waldenstrom Macroglobulinemia

2016
Functional analysis of the p.(Leu15Pro) and p.(Gly20Arg) sequence changes in the signal sequence of LDL receptor.
    Atherosclerosis, 2016, Volume: 250

    Topics: Animals; Arginine; CHO Cells; Cricetinae; Cricetulus; Endoplasmic Reticulum; Glycine; Heterozygote; Humans; Hyperlipoproteinemia Type II; Leucine; Microscopy, Confocal; Mutation; Pedigree; Proline; Protein Folding; Protein Sorting Signals; Protein Structure, Secondary; Receptors, LDL

2016
Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:7

    Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; Biological Transport; Chlorocebus aethiops; CHO Cells; Cholesterol; Cholesterol, HDL; COS Cells; Cricetulus; Endosomes; Genotype; HEK293 Cells; Humans; Leucine; Liver X Receptors; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Primary Cell Culture; Proline; Sterol Regulatory Element Binding Protein 2; Transfection

2016
Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:6

    Topics: Aminoisobutyric Acids; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Polymers; Proline; Quinolines; Spectrometry, Mass, Electrospray Ionization; Thiazoles

2016
Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease.
    Neurological research, 2016, Volume: 38, Issue:10

    Topics: Charcot-Marie-Tooth Disease; Connexins; DNA Mutational Analysis; Gap Junction beta-1 Protein; Green Fluorescent Proteins; HeLa Cells; Humans; Leucine; Male; Mutation, Missense; Proline; Protein Transport; Schwann Cells; Transfection

2016
Leucine-Enriched Essential Amino Acids Augment Mixed Protein Synthesis, But Not Collagen Protein Synthesis, in Rat Skeletal Muscle after Downhill Running.
    Nutrients, 2016, Jun-28, Volume: 8, Issue:7

    Topics: Amino Acids, Essential; Animals; Collagen; Female; Hydroxyproline; Leucine; Muscle Proteins; Muscle, Skeletal; Physical Conditioning, Animal; Proline; Protein Biosynthesis; Rats; Rats, Wistar; Running

2016
Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Acrylates; Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins

2016
Genetic analysis of CHCHD2 gene in Chinese Parkinson's disease.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2016, Volume: 171, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Asian People; China; DNA-Binding Proteins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Leucine; Male; Middle Aged; Mitochondrial Proteins; Mutation; Parkinson Disease; Proline; Risk Factors; Transcription Factors

2016
Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir.
    Molecular bioSystems, 2016, 11-15, Volume: 12, Issue:12

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Binding Sites; Catalytic Domain; Codon; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Humans; Hydrogen Bonding; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Molecular Conformation; Mutation; Oligopeptides; Proline; Protein Binding; Quinolines; Sulfonamides; Thiazoles; Viral Nonstructural Proteins

2016
Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Brain; Cell Line, Tumor; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose; Humans; Leucine; Membrane Proteins; Mutation; Neuroblastoma; Phosphorylation; Proline; RNA, Messenger; RNA, Small Interfering; Selenoproteins; tau Proteins; Transfection

2017
Association between GPX1 Pro189Leu polymorphism and the occurrence of bladder cancer in Morocco.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, Dec-30, Volume: 62, Issue:14

    Topics: Adult; Aged; Alleles; Base Sequence; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Middle Aged; Morocco; Polymorphism, Genetic; Proline; Risk Factors; Urinary Bladder Neoplasms

2016
The metabolites in peripheral blood mononuclear cells showed greater differences between patients with impaired fasting glucose or type 2 diabetes and healthy controls than those in plasma.
    Diabetes & vascular disease research, 2017, Volume: 14, Issue:2

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Fasting; Female; Glucose Metabolism Disorders; Humans; Inflammation Mediators; Leucine; Leukocytes, Mononuclear; Lysophosphatidylcholines; Male; Metabolomics; Middle Aged; Proline; Valine

2017
Discrepant platelet and plasma von Willebrand factor in von Willebrand disease patients with p.Pro2808Leufs*24.
    Journal of thrombosis and haemostasis : JTH, 2017, Volume: 15, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Platelets; Canada; Cells, Cultured; Endothelial Cells; Female; Genetic Variation; Hemorrhage; Heterozygote; Homozygote; Humans; Leucine; Male; Microscopy, Fluorescence; Middle Aged; Pedigree; Phenotype; Plasma; Proline; von Willebrand Disease, Type 3; von Willebrand Factor; Young Adult

2017
Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia.
    Neurobiology of aging, 2017, Volume: 56

    Topics: Adult; Alzheimer Disease; Asian People; Atrophy; Codon; Dementia; Exons; Genetic Association Studies; Genetic Predisposition to Disease; Helix-Loop-Helix Motifs; Humans; Leucine; Magnetic Resonance Imaging; Mutation, Missense; Neuroimaging; Parietal Lobe; Presenilin-1; Proline

2017
Kohamamides A, B, and C, Cyclic Depsipeptides from an Okeania sp. Marine Cyanobacterium.
    Journal of natural products, 2017, 06-23, Volume: 80, Issue:6

    Topics: Cyanobacteria; Depsipeptides; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leucine; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Proline; Structure-Activity Relationship

2017
Phase Separation Macrocyclization in a Complex Pharmaceutical Setting: Application toward the Synthesis of Vaniprevir.
    The Journal of organic chemistry, 2017, 07-21, Volume: 82, Issue:14

    Topics: Alkynes; Cyclization; Cyclopropanes; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Macromolecular Substances; Microwaves; Molecular Structure; Proline; Sulfonamides

2017
Formulation, Characterization and Stability Assessment of a Food-Derived Tripeptide, Leucine-Lysine-Proline Loaded Chitosan Nanoparticles.
    Journal of food science, 2017, Volume: 82, Issue:9

    Topics: Cell Line; Cell Survival; Chitosan; Gels; Humans; Leucine; Lysine; Nanoparticles; Particle Size; Peptides; Polyphosphates; Proline

2017
Pharmacokinetics, Safety, and Tolerability of Glecaprevir and Pibrentasvir in Healthy White, Chinese, and Japanese Adult Subjects.
    Journal of clinical pharmacology, 2017, Volume: 57, Issue:12

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Asian People; Benzimidazoles; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Half-Life; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; White People

2017
The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice.
    Brain : a journal of neurology, 2017, Oct-01, Volume: 140, Issue:10

    Topics: Age Factors; alpha-Synuclein; Animals; beta-N-Acetylhexosaminidases; Brain; Dopamine; Glucosylceramidase; Humans; Leucine; Mice; Mice, Transgenic; Mutation; Neurons; Proline; Psychomotor Performance; Smell; Substantia Nigra; Transduction, Genetic; Tyrosine 3-Monooxygenase

2017
Mavyret and Vosevi--two new combinations for chronic HCV infection.
    The Medical letter on drugs and therapeutics, 2017, 10-09, Volume: 59, Issue:1531

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome

2017
[Molecular recognition mechanism and motion of HCV NS3/4A protease with Faldaprevir analogue].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2016, May-25, Volume: 32, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Endopeptidases; Hepacivirus; Intracellular Signaling Peptides and Proteins; Leucine; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Serine Proteases; Thiazoles; Viral Nonstructural Proteins

2016
ALS-Related Mutant FUS Protein Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers.
    Neuro-degenerative diseases, 2017, Volume: 17, Issue:6

    Topics: Amyotrophic Lateral Sclerosis; Cell Nucleus; Cells, Cultured; Cytoplasmic Granules; Female; Fibroblasts; Follow-Up Studies; Humans; Leucine; Male; Mutation; Neural Conduction; Proline; Protein Transport; RNA-Binding Protein FUS; Skin; Subcellular Fractions; Time Factors; Tubulin

2017
Benefit-risk assessment for sofosbuvir/velpatasvir/voxilaprevir based on patient population and hepatitis C virus genotype: U. S. Food and Drug Administration's evaluation.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:2

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Risk Assessment; Sofosbuvir; Sulfonamides; Sustained Virologic Response; United States; United States Food and Drug Administration; Viral Nonstructural Proteins

2018
New Oral HCV Drug.
    The American journal of nursing, 2017, Volume: 117, Issue:11

    Topics: Administration, Oral; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Contraindications, Drug; Cyclopropanes; Drug Approval; Drug Combinations; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2017
Patient-Reported Outcomes Following Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir and Velpatasvir, With or Without Voxilaprevir.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018, Volume: 16, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Patient Reported Outcome Measures; Placebos; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Surveys and Questionnaires; Sustained Virologic Response

2018
Proton-pump inhibitors and glecaprevir plus pibrentasvir in HCV infection.
    The Lancet. Infectious diseases, 2017, Volume: 17, Issue:12

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Proton Pump Inhibitors; Protons; Pyrrolidines; Quinoxalines; Sulfonamides

2017
Proton-pump inhibitors and glecaprevir plus pibrentasvir in HCV infection - Authors' reply.
    The Lancet. Infectious diseases, 2017, Volume: 17, Issue:12

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Proton Pump Inhibitors; Protons; Pyrrolidines; Quinoxalines; Sulfonamides

2017
Sofosbuvir and velpatasvir with or without voxilaprevir in direct-acting antiviral-naïve chronic hepatitis C: patient-reported outcomes from POLARIS 2 and 3.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:2

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Multicenter Studies as Topic; Patient Reported Outcome Measures; Proline; Quinoxalines; Randomized Controlled Trials as Topic; Self Report; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2018
Biochemical Basis of Vosevi, a New Treatment for Hepatitis C
    Biochemistry, 2018, 02-06, Volume: 57, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Hepacivirus; Hepatitis; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Serine Proteases; Sofosbuvir; Sulfonamides; Viral Nonstructural Proteins

2018
Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C Infection
    Biochemistry, 2018, 02-06, Volume: 57, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Serine Proteases; Sulfonamides; Viral Nonstructural Proteins

2018
New Drugs 2018, part 1.
    Nursing, 2018, Volume: 48, Issue:2

    Topics: Aminoisobutyric Acids; Antibodies, Monoclonal; Antibodies, Neutralizing; Antipyrine; Benzamides; Benzimidazoles; Broadly Neutralizing Antibodies; Carbamates; Cyclopropanes; Drug Approval; Drug Combinations; Edaravone; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Naltrexone; Natriuretic Peptides; Proline; Pyridines; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; United States; United States Food and Drug Administration

2018
Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3.
    Molecular genetics and metabolism, 2018, Volume: 123, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Autophagy; Cardiomyopathy, Restrictive; Child; Heart; Heart Transplantation; Humans; Leucine; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Muscle, Skeletal; Mutation; Myocardium; Myofibrils; Proline

2018
Editorial: direct-acting antivirals significantly improve quality of life in patients with hepatitis C virus infection-Author's reply.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Patient Reported Outcome Measures; Proline; Quality of Life; Quinoxalines; Sofosbuvir; Sulfonamides

2018
Editorial: direct-acting antivirals significantly improve quality of life in patients with hepatitis C virus infection.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Patient Reported Outcome Measures; Proline; Quality of Life; Quinoxalines; Sofosbuvir; Sulfonamides

2018
Beyond one virus: vaccination against hepatitis B after hepatitis C treatment.
    The Lancet. Infectious diseases, 2018, Volume: 18, Issue:3

    Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Expeditions; Genotype; Hepatitis B; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Vaccination

2018
Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets.
    American journal of primatology, 2018, Volume: 80, Issue:10

    Topics: Administration, Intranasal; Animals; Callithrix; Female; Leucine; Male; Oxytocin; Pair Bond; Proline; Sexual Behavior, Animal; Social Behavior; Social Isolation

2018
New Treatment Options for Hepatitis C Virus Infection in End-Stage Kidney Disease: To Treat or Not to Treat.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2018, Volume: 72, Issue:1

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2018
Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice.
    Biochemical and biophysical research communications, 2018, 06-02, Volume: 500, Issue:2

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Gene Deletion; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Mice, SCID; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Failure; Viral Nonstructural Proteins

2018
Sofosbuvir + velpatasvir + voxilaprevir for the treatment of hepatitis C infection.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:7

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2018
P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:10

    Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Drug Resistance; Fatty Liver; Fibric Acids; Hyperlipidemias; Hypolipidemic Agents; Leucine; Mice; Mice, Transgenic; Mutation, Missense; PPAR gamma; Proline

2018
Effects of rearing system on meat quality, fatty acid and amino acid profiles of Hu lambs.
    Animal science journal = Nihon chikusan Gakkaiho, 2018, Volume: 89, Issue:8

    Topics: Alanine; Amino Acids; Animal Feed; Animal Husbandry; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Food Quality; Leucine; Meat; Proline; Sheep; Time Factors; Weight Gain

2018
De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.
    PLoS pathogens, 2018, Volume: 14, Issue:5

    Topics: Acetates; Acetyl Coenzyme A; Acetyltransferases; Acyl Coenzyme A; Alcohol Oxidoreductases; Animals; Carbon; Fatty Acids; Gene Expression Regulation; Gene Knockout Techniques; Glucose; Insect Vectors; Leucine; Mevalonic Acid; Proline; Sterols; Threonine; Trypanosoma brucei brucei; Tsetse Flies

2018
Retreatment of hepatitis C virus: can it get any better?
    The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:8

    Topics: Aminoisobutyric Acids; Carbamates; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides

2018
Favorable efficacy of glecaprevir plus pibrentasvir as salvage therapy for HCV failures to prior direct-acting antivirals regimens.
    Journal of medical virology, 2019, Volume: 91, Issue:1

    Topics: Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Failure; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Salvage Therapy; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2019
Hepatitis C virus genetic diversity by geographic region within genotype 1-6 subtypes among patients treated with glecaprevir and pibrentasvir.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Genetic Variation; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Phylogeny; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Viral Nonstructural Proteins

2018
Pharmacokinetics and safety of glecaprevir and pibrentasvir in HCV-negative subjects with hepatic impairment.
    European journal of clinical pharmacology, 2019, Volume: 75, Issue:2

    Topics: Adolescent; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Liver; Liver Diseases; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2019
Glecaprevir/Pibrentasvir (Mavyret) for the Treatment of Chronic Hepatitis C.
    American family physician, 2018, 11-15, Volume: 98, Issue:10

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2018
Glecaprevir/Pibrentasvir Induced Cholestatic Jaundice in a HCV Patient with Renal Failure. A Case Presentation.
    Current drug safety, 2019, Volume: 14, Issue:1

    Topics: Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Jaundice, Obstructive; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency; Sulfonamides

2019
Glecaprevir and Pibrentasvir for Japanese Patients with Human Immunodeficiency Virus and Genotype 3 Hepatitis C Virus Coinfection: A Report of Three Cases.
    Internal medicine (Tokyo, Japan), 2019, Mar-15, Volume: 58, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Coinfection; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2019
Direct-acting antivirals for chronic hepatitis C virus genotype 5 and 6 infections.
    The lancet. Gastroenterology & hepatology, 2019, Volume: 4, Issue:1

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2019
APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?
    Hepatology international, 2019, Volume: 13, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Contraindications, Drug; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response

2019
The Successful Retreatment with Glecaprevir and Pibrentasvir of Genotype 1 or 2 HCV-infected Hemodialysis Patients who Failed to Respond to NS5A and Protease Inhibitor Treatment.
    Internal medicine (Tokyo, Japan), 2019, Apr-01, Volume: 58, Issue:7

    Topics: Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Isoquinolines; Lactams, Macrocyclic; Leucine; Middle Aged; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Renal Dialysis; Retreatment; Sulfonamides; Treatment Failure; Valine

2019
UBC9 Mutant Reveals the Impact of Protein Dynamics on Substrate Selectivity and SUMO Chain Linkages.
    Biochemistry, 2019, 02-12, Volume: 58, Issue:6

    Topics: Amino Acid Sequence; Amino Acid Substitution; Catalytic Domain; Cysteine; Humans; Leucine; Mutation; Proline; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Small Ubiquitin-Related Modifier Proteins; Substrate Specificity; Sumoylation; Ubiquitin-Conjugating Enzymes

2019
Fibrosing cholestatic hepatitis in a kidney transplant recipient with hepatitis C virus.
    CEN case reports, 2019, Volume: 8, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Bilirubin; Cholestasis; Cyclopropanes; Fatal Outcome; Hepacivirus; Hepatitis C; Humans; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Transplant Recipients; Viral Load

2019
NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir.
    Journal of gastroenterology, 2019, Volume: 54, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retreatment; Sequence Deletion; Sulfonamides; Sustained Virologic Response; Treatment Failure; Viral Nonstructural Proteins

2019
Public health round-up.
    Bulletin of the World Health Organization, 2019, Jan-01, Volume: 97, Issue:1

    Topics: Adenosine Monophosphate; Alanine; Aminoisobutyric Acids; Anti-Bacterial Agents; Antibodies, Monoclonal; Benzimidazoles; Cyclopropanes; Democratic Republic of the Congo; Disease Outbreaks; Drug Resistance, Bacterial; Global Health; Hemorrhagic Fever, Ebola; Hepatitis C; Humans; Interinstitutional Relations; Lactams, Macrocyclic; Leucine; Malaria; Measles; Measles Vaccine; Poliomyelitis; Proline; Public Health Practice; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Ribonucleotides; Sulfonamides; Tuberculosis

2019
Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes.
    Pediatric diabetes, 2019, Volume: 20, Issue:3

    Topics: Amino Acid Substitution; Child; Diabetes Mellitus; DNA Mutational Analysis; Exome Sequencing; Hepatocyte Nuclear Factor 3-beta; Humans; Leucine; Male; Models, Molecular; Mutation, Missense; Polymorphism, Single Nucleotide; Proline; Syndrome

2019
    Journal of clinical microbiology, 2019, Volume: 57, Issue:4

    Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Protease Inhibitors; Quinoxalines; Sulfonamides; Viral Nonstructural Proteins

2019
A Comparison of the Ability of Leu
    Molecular pharmacology, 2019, Volume: 95, Issue:4

    Topics: Animals; Calcium; CHO Cells; Cricetulus; Humans; Leucine; Membrane Potentials; Oxytocin; Potassium; Potassium Channels, Calcium-Activated; Proline; Receptors, Oxytocin; Signal Transduction; Type C Phospholipases

2019
Renal transplantation from seropositive hepatitis C virus donors to seronegative recipients in Spain: a prospective study.
    Transplant international : official journal of the European Society for Organ Transplantation, 2019, Volume: 32, Issue:7

    Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Donor Selection; Female; Graft Rejection; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Living Donors; Male; Middle Aged; Patient Safety; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Spain; Sulfonamides; Treatment Outcome

2019
HLA-C*07:465, a novel HLA-C*07 variant, detected in a Singaporean Chinese individual.
    HLA, 2019, Volume: 93, Issue:6

    Topics: Alleles; Asian People; Bone Marrow Transplantation; Codon; Exons; Haplotypes; HLA-C Antigens; Humans; Leucine; Polymorphism, Single Nucleotide; Proline; Sequence Analysis, DNA; Singapore

2019
Safety of Hepatitis C Viral Protease Inhibitors in Compensated Cirrhotics: Lingering Concerns Put to Rest?
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019, 10-30, Volume: 69, Issue:10

    Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides

2019
Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic HCV infection and psychiatric disorders: An integrated analysis.
    Journal of viral hepatitis, 2019, Volume: 26, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antidepressive Agents; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Mental Disorders; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Adherence and Compliance; Young Adult

2019
Bi-allelic Pro291Leu variant in KCNQ4 leads to early onset non-syndromic hearing loss.
    Gene, 2019, Jul-15, Volume: 705

    Topics: Age of Onset; Consanguinity; Deafness; Exome Sequencing; Female; Genetic Heterogeneity; Genetic Predisposition to Disease; Humans; KCNQ Potassium Channels; Leucine; Male; Mutation, Missense; Pedigree; Proline

2019
Contemporary HCV pangenotypic DAA treatment protocols are exclusionary to real world HIV-HCV co-infected patients.
    BMC infectious diseases, 2019, May-03, Volume: 19, Issue:1

    Topics: Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Benzimidazoles; Carbamates; Coinfection; Cyclopropanes; Drug Interactions; Female; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome; Viral Load

2019
Sofosbuvir/Velpatasvir/Voxilaprevir for Previous Treatment Failures With Glecaprevir/Pibrentasvir in Chronic Hepatitis C Infection.
    The American journal of gastroenterology, 2019, Volume: 114, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome

2019
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
    Bioorganic & medicinal chemistry letters, 2019, 08-15, Volume: 29, Issue:16

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Dose-Response Relationship, Drug; Drug Combinations; Drug Discovery; Hepacivirus; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Microbial Sensitivity Tests; Molecular Structure; Proline; Protease Inhibitors; Quinoxalines; Sofosbuvir; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins

2019
Effects of Pro1266Leu mutation on structure and function of glycoprotein Ib binding domain of von Willebrand factor.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:10

    Topics: Leucine; Models, Molecular; Molecular Dynamics Simulation; Mutation; Platelet Glycoprotein GPIb-IX Complex; Principal Component Analysis; Proline; Protein Binding; Protein Domains; Protein Interaction Maps; Protein Structure, Secondary; Structure-Activity Relationship; von Willebrand Factor

2019
Real-life glecaprevir/pibrentasvir in a large cohort of patients with hepatitis C virus infection: The MISTRAL study.
    Liver international : official journal of the International Association for the Study of the Liver, 2019, Volume: 39, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Italy; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Longitudinal Studies; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Substance Abuse, Intravenous; Sulfonamides; Sustained Virologic Response; Young Adult

2019
Role of NS5A-L31/Y93 Double Wild-type in Failure of Glecaprevir/Pibrentasvir Double Therapy in Two Patients with a History of Direct-acting Antiviral Agent Failure: An Ultra-deep Sequencing Analysis.
    Internal medicine (Tokyo, Japan), 2019, Sep-15, Volume: 58, Issue:18

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepatitis C, Chronic; Humans; Interferons; Lactams, Macrocyclic; Leucine; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2019
A Cost-Effectiveness Analysis of Shortened Direct-Acting Antiviral Treatment in Genotype 1 Noncirrhotic Treatment-Naive Patients With Chronic Hepatitis C Virus.
    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2019, Volume: 22, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cost-Benefit Analysis; Cyclopropanes; Decision Trees; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Markov Chains; Proline; Quinoxalines; Sofosbuvir; State Medicine; Sulfonamides; United Kingdom

2019
Evaluation of 8-week glecaprevir/pibrentasvir treatment in direct-acting antiviral-naïve noncirrhotic HCV genotype 1 and 2infected patients in a real-world setting in Japan.
    Journal of viral hepatitis, 2019, Volume: 26, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sequence Analysis, DNA; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome; Young Adult

2019
Real-world effectiveness and safety of glecaprevir/pibrentasvir in Asian patients with chronic hepatitis C.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019, Volume: 118, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Sustained Virologic Response; Taiwan

2019
Successful prolonged treatment of glecaprevir/pibrentasvir for chronic hepatitis C patient with treatment failure after 8-week therapy: a case report.
    Clinical journal of gastroenterology, 2019, Volume: 12, Issue:6

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Genome, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Proline; Pyrrolidines; Quinoxalines; Recurrence; RNA, Viral; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome

2019
Protective effects of di- and tri-peptides containing proline, glycine, and leucine on liver enzymology and histopathology of diabetic mice.
    Archives of physiology and biochemistry, 2022, Volume: 128, Issue:1

    Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Experimental; Glycine; Leucine; Liver; Mice; Peptides; Proline

2022
Efficacy and Safety of Glecaprevir/pibrentasvir in a Patient With HCV-Induced Porphyria Cutanea Tarda Receiving Vedolizumab for Crohn´s Disease.
    Journal of Crohn's & colitis, 2020, May-21, Volume: 14, Issue:4

    Topics: Aminoisobutyric Acids; Antibodies, Monoclonal, Humanized; Benzimidazoles; Crohn Disease; Cyclopropanes; Gastrointestinal Agents; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Porphyria Cutanea Tarda; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Clinical Relevance of the High Prevalence of MYD88 L265P Mutated Vitreoretinal Lymphoma Identified by Droplet Digital Polymerase Chain Reaction.
    Ocular immunology and inflammation, 2021, Apr-03, Volume: 29, Issue:3

    Topics: Adult; Aged; Female; Humans; Immunohistochemistry; Intraocular Lymphoma; Leucine; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Mutation, Missense; Myeloid Differentiation Factor 88; Polymerase Chain Reaction; Proline; Prospective Studies; Retinal Neoplasms; Vitrectomy; Vitreous Body; Waldenstrom Macroglobulinemia

2021
Retreatment Options for Patients Who Failed Direct-Acting Antiviral Regimens Containing NS5A Inhibitors: Is Glecaprevir/Pibrentasvir a Valid and Robust Option?
    Gastroenterology, 2019, Volume: 157, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Humans; Infections; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Treatment Failure

2019
Efficacy and Safety of 8 Weeks of Glecaprevir/Pibrentasvir in Treatment-Naïve, HCV-Infected Patients with APRI ≤ 1 in a Single-Arm, Open-Label, Multicenter Study.
    Advances in therapy, 2019, Volume: 36, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Comorbidity; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Young Adult

2019
Are all cirrhotic patients equal?
    Journal of hepatology, 2020, Volume: 72, Issue:3

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Expeditions; Genotype; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection: Real-world effectiveness and safety in Taiwan.
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Asia, Eastern; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Taiwan

2020
A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan.
    Advances in therapy, 2020, Volume: 37, Issue:1

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cost-Benefit Analysis; Cyclopropanes; Drug Therapy, Combination; Female; Fluorenes; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Uridine Monophosphate

2020
Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection.
    Internal medicine (Tokyo, Japan), 2020, Apr-01, Volume: 59, Issue:7

    Topics: Adolescent; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Child; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Valine

2020
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir.
    ACS chemical biology, 2020, 02-21, Volume: 15, Issue:2

    Topics: Amides; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Catalytic Domain; Crystallography, X-Ray; Cyclopropanes; Hepacivirus; Lactams, Macrocyclic; Leucine; Mutation; Proline; Protein Binding; Quinoxalines; Serine Proteases; Serine Proteinase Inhibitors; Sulfonamides; Viral Nonstructural Proteins

2020
Hepatitis C and Compensated Cirrhosis Drug Approved for Eight-Week Treatment.
    The American journal of nursing, 2020, Volume: 120, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Approval; Drug Combinations; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; United States

2020
Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real-world setting: A large, multicenter study from Japan.
    Journal of gastroenterology and hepatology, 2020, Volume: 35, Issue:8

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cohort Studies; Cyclopropanes; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Multicenter Studies as Topic; Proline; Propensity Score; Pyrrolidines; Quinoxalines; Severity of Illness Index; Sulfonamides; Time Factors

2020
Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection and severe renal impairment.
    Journal of viral hepatitis, 2020, Volume: 27, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Retrospective Studies; Sulfonamides; Sustained Virologic Response; Taiwan

2020
Successful treatment with glecaprevir/pibrentasvir for chronic hepatitis C complicated by primary biliary cholangitis.
    Clinical journal of gastroenterology, 2020, Volume: 13, Issue:5

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis, Biliary; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Editorial: glecaprevir/pibrentasvir for the treatment of hepatitis C virus-do baseline resistance-associated substitutions matter?
    Alimentary pharmacology & therapeutics, 2020, Volume: 51, Issue:7

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Editorial: glecaprevir/pibrentasvir for the treatment of hepatitis C virus-do baseline resistance-associated substitutions matter? Authors' reply.
    Alimentary pharmacology & therapeutics, 2020, Volume: 51, Issue:7

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Utilization of Amino Acid-Rich Wastes for Microbial Lipid Production.
    Applied biochemistry and biotechnology, 2020, Volume: 191, Issue:4

    Topics: Amino Acids; Animals; Basidiomycota; Biofuels; Biomass; Carbohydrates; Fatty Acids; Fishes; Hydrogen-Ion Concentration; Industrial Microbiology; Industrial Waste; Leucine; Lipids; Meat; Proline; Sheep; Tryptophan

2020
Successful ongoing retreatment with glecaprevir/pibrentasvir + sofosbuvir + ribavirin in a patient with HCV genotype 3 who failed glecaprevir/pibrentasvir with both NS3 and NS5A resistance.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020, Volume: 26, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome

2020
Efficacy and safety of glecaprevir/pibrentasvir in patients with hepatitis C virus infection aged ≥75 years.
    Geriatrics & gerontology international, 2020, Volume: 20, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepatitis C; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Treatment Outcome

2020
Effectiveness of 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve, Compensated Cirrhotic Patients with Chronic Hepatitis C Infection.
    Advances in therapy, 2020, Volume: 37, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Databases, Factual; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; United States

2020
Real-world effectiveness of glecaprevir/pibrentasvir and ledipasvir/sofosbuvir for mixed genotype hepatitis C infection: A multicenter pooled analysis in Taiwan.
    Journal of viral hepatitis, 2020, Volume: 27, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Fluorenes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Taiwan

2020
Renal function in HCV therapy: Just another thing to ignore?
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:5

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Successful fourth line treatment of a relapse patient with chronic hepatitis C virus infection genotype 3a using sofosbuvir, glecaprevir/pibrentasvir, and ribavirin: a case report.
    Zeitschrift fur Gastroenterologie, 2020, Volume: 58, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Middle Aged; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Outcome

2020
Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy.
    Bioscience reports, 2020, 06-26, Volume: 40, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Betacoronavirus; Computer Simulation; Cyclopropanes; Drug Evaluation, Preclinical; Lactams, Macrocyclic; Leucine; Maraviroc; Molecular Structure; Proline; Protease Inhibitors; Quinoxalines; SARS-CoV-2; Sulfonamides

2020
Outcomes of the Treatment with Glecaprevir/Pibrentasvir following heart transplantation utilizing hepatitis C viremic donors.
    Clinical transplantation, 2020, Volume: 34, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Heart Transplantation; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome; Viremia

2020
Efficacy of sofosbuvir/velpatasvir/voxilaprevir in direct-acting antiviral experienced patients with hepatitis C virus.
    European journal of gastroenterology & hepatology, 2021, 06-01, Volume: 33, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response

2021
Sofosbuvir/velpatasvir/voxilaprevir plus ribavirin for chronic hepatitis C patients with direct acting antiviral failures: Implications for viral elimination in Taiwan.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2020, Volume: 119, Issue:12

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Taiwan

2020
Management and tolerability of glecaprevir-pibrentasvir pharmacotherapy in hepatitis C viremic heart and lung transplant recipients.
    Clinical transplantation, 2020, Volume: 34, Issue:10

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Lung; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Transplant Recipients; Viremia

2020
Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen.
    The Journal of antimicrobial chemotherapy, 2020, 11-01, Volume: 75, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Genotype; Germany; Hepacivirus; Humans; Italy; Lactams, Macrocyclic; Leucine; Prevalence; Proline; Pyrrolidines; Quinoxalines; Retreatment; Retrospective Studies; Spain; Sulfonamides; Viral Nonstructural Proteins

2020
Glecaprevir-pibrentasvir for chronic hepatitis C: Comparing treatment effect in patients with and without end-stage renal disease in a real-world setting.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Sustained Virologic Response

2020
Effectiveness of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C virus infection and virologic failure to direct-acting antivirals.
    Medicina clinica, 2021, 07-23, Volume: 157, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2021
Real-Life Effectiveness and Safety of Glecaprevir/Pibrentasvir for Korean Patients with Chronic Hepatitis C at a Single Institution.
    Gut and liver, 2021, 05-15, Volume: 15, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cohort Studies; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Middle Aged; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Republic of Korea; Retrospective Studies; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2021
Testicular Involvement is a Hallmark of Apo A-I Leu75Pro Mutation Amyloidosis.
    The Journal of clinical endocrinology and metabolism, 2020, 12-01, Volume: 105, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyloidosis; Apolipoprotein A-I; Cohort Studies; Databases, Factual; Genetic Predisposition to Disease; Humans; Italy; Leucine; Male; Middle Aged; Mutation, Missense; Proline; Retrospective Studies; Testicular Diseases; Testis; Young Adult

2020
Use of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus infection and severe renal impairment.
    Clinical and molecular hepatology, 2020, Volume: 26, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Child; Cyclopropanes; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency; Sulfonamides

2020
Efficacy and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir for Hepatitis C Virus (HCV) NS5A-Inhibitor Experienced Patients With Difficult to Cure Characteristics.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 11-02, Volume: 73, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2021
Sofosbuvir, velpatasvir, and voxilaprevir for patients with failure of previous direct-acting antiviral therapy for chronic hepatitis C: Results from the German Hepatitis C-Registry (DHC-R).
    Zeitschrift fur Gastroenterologie, 2020, Volume: 58, Issue:9

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Registries; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2020
Hepatitis C therapy with grazoprevir/elbasvir and glecaprevir/pibrentasvir in patients with advanced chronic kidney disease: data from the German Hepatitis C-Registry (DHC-R).
    European journal of gastroenterology & hepatology, 2022, 01-01, Volume: 34, Issue:1

    Topics: Amides; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Registries; Renal Insufficiency, Chronic; Ribavirin; Sulfonamides; Sustained Virologic Response

2022
More evidence that direct acting antiviral therapy is safe and effective in cirrhosis and chronic kidney disease including peritoneal dialysis.
    Clinical and molecular hepatology, 2020, Volume: 26, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Peritoneal Dialysis; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Sulfonamides

2020
Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis.
    Chemical & pharmaceutical bulletin, 2020, Dec-01, Volume: 68, Issue:12

    Topics: Amides; Amino Acid Sequence; Cathepsin A; Cysteine; Hydrazines; Leucine; Peptides; Proline; Proteins; Structure-Activity Relationship; Sulfhydryl Compounds

2020
Presentation and management of congenital myasthenic syndrome with a homozygous Agrin variant (Pro1448Leu).
    Clinical neurology and neurosurgery, 2020, Volume: 199

    Topics: Adolescent; Agrin; Cholinesterase Inhibitors; Diagnosis, Differential; Disease Management; Female; Genetic Variation; Homozygote; Humans; Leucine; Myasthenic Syndromes, Congenital; Proline; Pyridostigmine Bromide

2020
Letter: now is the time to remove complexity from HCV guidelines to ensure that elimination remains a priority.
    Alimentary pharmacology & therapeutics, 2020, Volume: 52, Issue:6

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Letter: now is the time to remove complexity from HCV guidelines to ensure that elimination remains a priority-authors' reply.
    Alimentary pharmacology & therapeutics, 2020, Volume: 52, Issue:6

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2020
Is an 8-week regimen of glecaprevir/pibrentasvir sufficient for all hepatitis C virus infected patients in the real-world experience?
    Journal of gastroenterology and hepatology, 2021, Volume: 36, Issue:7

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides

2021
Hepatitis C and beta-thalassemia major in children: experience with glecaprevir/pibrentasvir.
    Revista espanola de enfermedades digestivas, 2021, Volume: 113, Issue:2

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; beta-Thalassemia; Child; China; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Feasibility and efficacy of 8 week Glecaprevir/Pibrentasvir to treat incarcerated viraemic HCV patients: A case-control study.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:2

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Case-Control Studies; Cyclopropanes; Feasibility Studies; Genotype; Hepacivirus; Hepatitis C; Humans; Italy; Lactams, Macrocyclic; Leucine; Middle Aged; Prisoners; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Tacrolimus concentrations were not affected by glecaprevir/pibrentasvir treatment for hepatitis C virus infection in an adult living donor liver transplant recipient with uremia.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2021, Volume: 120, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Transplantation; Living Donors; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Tacrolimus; Uremia

2021
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
    The EMBO journal, 2021, 03-15, Volume: 40, Issue:6

    Topics: 5-Methylcytosine; Adaptation, Physiological; Animals; Caenorhabditis elegans; CRISPR-Cas Systems; Cytosine; Gene Editing; Heat-Shock Response; Hot Temperature; Leucine; Methyltransferases; Mitochondria; Proline; Protein Biosynthesis; Ribosomes; RNA; RNA Processing, Post-Transcriptional

2021
Reply to "Tacrolimus concentrations were not affected by glecaprevir/pibrentasvir treatment for hepatitis C virus infection in an adult living donor liver transplant recipient with uremia".
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2021, Volume: 120, Issue:6

    Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Liver Transplantation; Living Donors; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Tacrolimus; Uremia

2021
Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity.
    Proteins, 2021, Volume: 89, Issue:6

    Topics: Alanine; Aminopeptidases; Bacterial Proteins; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Hydrolases; Hydrophobic and Hydrophilic Interactions; Kinetics; Leucine; Models, Molecular; Mycobacterium tuberculosis; Phenylalanine; Proline; Prolyl Oligopeptidases; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Puromycin; Recombinant Proteins; Substrate Specificity

2021
Exploring of paritaprevir and glecaprevir resistance due to A156T mutation of HCV NS3/4A protease: molecular dynamics simulation study.
    Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:12

    Topics: Aminoisobutyric Acids; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Lactams, Macrocyclic; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Protease Inhibitors; Quinoxalines; Serine Proteases; Sulfonamides; Viral Nonstructural Proteins

2022
Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 01-26, Volume: 118, Issue:4

    Topics: Binding Sites; Cloning, Molecular; Coenzymes; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Kinetics; Leucine; Models, Molecular; Molecular Dynamics Simulation; Mutation; NADP; Proline; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; Substrate Specificity

2021
Structural basis for a complex I mutation that blocks pathological ROS production.
    Nature communications, 2021, 01-29, Volume: 12, Issue:1

    Topics: Amino Acid Substitution; Animals; Cryoelectron Microscopy; Disease Models, Animal; Disease Resistance; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Humans; Isolated Heart Preparation; Leucine; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membranes; Myocardial Reperfusion Injury; NAD; NADH Dehydrogenase; Oxidation-Reduction; Point Mutation; Proline; Reactive Oxygen Species

2021
Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc.
    Life sciences, 2021, Apr-15, Volume: 271

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Genetic Variation; HEK293 Cells; Histones; Humans; Lentivirus; Leucine; Mice; Mice, Nude; Mutation; Neoplasms; Nucleotides; Proline; Proto-Oncogene Proteins c-myc; Up-Regulation; Xenograft Model Antitumor Assays

2021
Real-world effectiveness and safety of glecaprevir/pibrentasvir therapy in patients with chronic hepatitis C virus infection in Switzerland.
    Swiss medical weekly, 2021, 01-18, Volume: 151

    Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Switzerland

2021
Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.
    Signal transduction and targeted therapy, 2021, 02-04, Volume: 6, Issue:1

    Topics: Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cyclopropanes; Cysteine Proteinase Inhibitors; Hepacivirus; Humans; Leucine; Proline; SARS-CoV-2; Sulfones; Urea

2021
Changing epidemiology of patients treated with direct acting antivirals for HCV and persistently high SVR12 in an endemic area for HCV infection in Italy: real-life 'LIver Network Activity' (LINA) cohort update results.
    Expert review of gastroenterology & hepatology, 2021, Volume: 15, Issue:9

    Topics: Adult; Age Distribution; Aged; Amides; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Carbamates; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Italy; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Sustained Virologic Response

2021
Glecaprevir/pibrentasvir is safe and effective in hepatitis C patients with cirrhosis: Real-world data from the German Hepatitis C-Registry.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Registries; Sulfonamides; Sustained Virologic Response

2021
Severe Liver Injury Associated with Glecaprevir Plus Pibrentasvir Therapy in a Patient with Treatment-naïve Hepatitis C Virus Infection.
    Internal medicine (Tokyo, Japan), 2021, Aug-01, Volume: 60, Issue:15

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses.
    ACS infectious diseases, 2021, 03-12, Volume: 7, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Carbonates; Cathepsin L; Cell Line; Chlorocebus aethiops; Coronavirus 229E, Human; Coronavirus 3C Proteases; Coronavirus NL63, Human; Coronavirus OC43, Human; COVID-19 Drug Treatment; Drug Combinations; Glycoproteins; HEK293 Cells; Humans; Leucine; Middle East Respiratory Syndrome Coronavirus; Oligopeptides; Proline; SARS-CoV-2; Serine Endopeptidases; Sulfonic Acids; Vero Cells

2021
Glecaprevir/pibrentasvir + sofosbuvir + ribavirin offers high cure rate for hepatitis C virus retreatment in real-world settings.
    Journal of hepatology, 2021, Volume: 75, Issue:1

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retreatment; Ribavirin; Sofosbuvir; Sulfonamides

2021
Salvage Therapy with Sofosbuvir/Velpatasvir/Voxilaprevir in DAA-experienced Patients: Results from a Prospective Canadian Registry.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 06-01, Volume: 72, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Canada; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Quinoxalines; Registries; Salvage Therapy; Sofosbuvir; Sulfonamides

2021
Resistance-associated substitutions after sofosbuvir/velpatasvir/voxilaprevir triple therapy failure.
    Journal of viral hepatitis, 2021, Volume: 28, Issue:9

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Failure; Viral Nonstructural Proteins

2021
Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study.
    Molecules (Basel, Switzerland), 2021, Mar-17, Volume: 26, Issue:6

    Topics: Antiviral Agents; Binding Sites; Computer Simulation; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Databases, Protein; Diarylquinolines; Dihydropyridines; Humans; Indoles; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitrobenzenes; Nitrophenols; Organophosphorus Compounds; Piperazines; Proline; Protease Inhibitors; Pyrrolidinones; SARS-CoV-2

2021
Reply to: "Glecaprevir/pibrentasvir + sofosbuvir + ribavirin offers high cure rate for hepatitis C virus retreatment in real-world settings".
    Journal of hepatology, 2021, Volume: 75, Issue:1

    Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retreatment; Ribavirin; Sofosbuvir; Sulfonamides

2021
Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report.
    BMC infectious diseases, 2021, Apr-27, Volume: 21, Issue:1

    Topics: Aminoisobutyric Acids; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Benzimidazoles; Cyclophosphamide; Cyclopropanes; Doxorubicin; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Prednisone; Proline; Pyrrolidines; Quinoxalines; Rituximab; RNA, Viral; Sulfonamides; Sustained Virologic Response; Vincristine; Viral Load

2021
Improved Protein and PTM Characterization with a Practical Electron-Based Fragmentation on Q-TOF Instruments.
    Journal of the American Society for Mass Spectrometry, 2021, Aug-04, Volume: 32, Issue:8

    Topics: Disulfides; Electrons; Glycosylation; Insulin; Isoaspartic Acid; Leucine; Lysine; Mass Spectrometry; Phosphopeptides; Phosphorylation; Proline; Protein Processing, Post-Translational; Proteins; Software; Substance P

2021
Effect of itraconazole on the pharmacokinetics of faldaprevir in healthy subjects.
    Die Pharmazie, 2021, 05-01, Volume: 76, Issue:5

    Topics: Adult; Aminoisobutyric Acids; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Leucine; Male; Middle Aged; Proline; Quinolines; Thiazoles

2021
Glecaprevir/pibrentasvir for 8 weeks in patients with compensated cirrhosis: Safety and effectiveness data from the German Hepatitis C-Registry.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:7

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Registries; Sulfonamides; Sustained Virologic Response

2021
Inhibition of microbial production of the malodorous substance isovaleric acid by 4,4' dichloro 2-hydroxydiphenyl ether (DCPP).
    MicrobiologyOpen, 2021, Volume: 10, Issue:2

    Topics: Anti-Infective Agents; Corynebacterium; Hemiterpenes; Humans; Laundering; Leucine; Odorants; Oligopeptides; Pentanoic Acids; Proline; Pyridines; Skin; Staphylococcus aureus; Textiles

2021
Sofosbuvir, Glecaprevir, Pibrentasvir, and Ribavirin as a Rescue Therapy in Difficult-to-Treat HCV Patients.
    Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Monitoring; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Medication Therapy Management; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2021
Safety of Patients with Hepatitis C Virus Treated with Glecaprevir/Pibrentasvir from Clinical Trials and Real-World Cohorts.
    Advances in therapy, 2021, Volume: 38, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carcinoma, Hepatocellular; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Sofosbuvir/Velpatasvir Plus Ribavirin Combination Therapy for Patients with Hepatitis C Virus Genotype 1a, 2a, or 3b after Glecaprevir/Pibrentasvir Therapy Failed.
    Internal medicine (Tokyo, Japan), 2021, Nov-01, Volume: 60, Issue:21

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Outcome

2021
Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment.
    Internal medicine (Tokyo, Japan), 2021, Nov-01, Volume: 60, Issue:21

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cholesterol, HDL; Cholesterol, LDL; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Non-pharmacologic direct cost of a simplified strategy with glecaprevir/pibrentasvir for 8 weeks in naïve non-cirrhotic patients with hepatitis C implemented in clinical practice. The Just SIMPLE Study.
    Gastroenterologia y hepatologia, 2022, Volume: 45, Issue:5

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides

2022
Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332.
    Journal of enzyme inhibition and medicinal chemistry, 2021, Volume: 36, Issue:1

    Topics: Antiviral Agents; Humans; Lactams; Leucine; Ligands; Molecular Dynamics Simulation; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; SARS-CoV-2; Software

2021
In silico drug repurposing for the treatment of heart diseases using gene expression data and molecular docking techniques.
    Biochemical and biophysical research communications, 2021, 10-01, Volume: 572

    Topics: Aminoisobutyric Acids; Aminopterin; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Daunorubicin; Digoxin; Drug Repositioning; Gene Expression; Heart Diseases; Humans; Lactams, Macrocyclic; Leucine; Ligands; Methylergonovine; Molecular Docking Simulation; Morpholines; Proline; Quinoxalines; Sulfonamides

2021
Effect of glecaprevir/pibrentasvir on weight-adjusted tacrolimus trough/dose ratios in heart and kidney transplant recipients.
    Transplant infectious disease : an official journal of the Transplantation Society, 2021, Volume: 23, Issue:5

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Tacrolimus; Transplant Recipients

2021
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.
    Bioorganic & medicinal chemistry letters, 2021, 10-15, Volume: 50

    Topics: Coronavirus 3C Proteases; COVID-19; Cysteine; Humans; Lactams; Leucine; Nitriles; Peptides; Peptidomimetics; Proline; Protease Inhibitors; SARS-CoV-2; Structure-Activity Relationship; Substrate Specificity

2021
High Sustained Virologic Response Rates of Glecaprevir/Pibrentasvir in Patients With Dosing Interruption or Suboptimal Adherence.
    The American journal of gastroenterology, 2021, 09-01, Volume: 116, Issue:9

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2021
Computational simulations on the binding and reactivity of a nitrile inhibitor of the SARS-CoV-2 main protease.
    Chemical communications (Cambridge, England), 2021, Sep-09, Volume: 57, Issue:72

    Topics: Binding Sites; Catalytic Domain; Coronavirus 3C Proteases; COVID-19; Humans; Lactams; Leucine; Molecular Dynamics Simulation; Nitriles; Proline; Protease Inhibitors; Quantum Theory; SARS-CoV-2; Thermodynamics

2021
Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations.
    International journal of molecular sciences, 2021, Aug-24, Volume: 22, Issue:17

    Topics: Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Coronavirus Protease Inhibitors; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Lopinavir; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Proline; Ritonavir; SARS-CoV-2

2021
Sofosbuvir/velpatasvir/voxilaprevir for hepatitis C virus retreatment in decompensated cirrhosis.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:12

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides

2021
Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease.
    Journal of molecular graphics & modelling, 2022, Volume: 110

    Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19; Humans; Lactams; Leucine; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Proline; Protease Inhibitors; SARS-CoV-2

2022
Successful treatment of Japanese hemophilia patient co-infected with HIV and HCV genotype 4a by glecaprevir/pibrentasvir therapy.
    Clinical journal of gastroenterology, 2021, Volume: 14, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Coinfection; Cyclopropanes; Genotype; Hemophilia A; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Japan; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
[Glecaprevir/Pibrentasvir + Sofosbuvir + Ribavirin as a salvage regimen after Sofosbuvir + Velpatasvir + Voxilaprevir re-treatment failure].
    Zeitschrift fur Gastroenterologie, 2022, Volume: 60, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Child; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Failure; Treatment Outcome

2022
Cost-effectiveness analysis of glecaprevir/pibrentasvir regimen for treating Chinese patients with chronic hepatitis C genotype 1 and genotype 2 infection.
    Annals of palliative medicine, 2021, Volume: 10, Issue:10

    Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; China; Cost-Benefit Analysis; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2021
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.
    Protein & cell, 2022, Volume: 13, Issue:9

    Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19; Humans; Lactams; Leucine; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Proline; Protease Inhibitors; SARS-CoV-2

2022
Virtual Double-System Single-Box for Absolute Dissociation Free Energy Calculations in GROMACS.
    Journal of chemical information and modeling, 2021, 11-22, Volume: 61, Issue:11

    Topics: Antiviral Agents; COVID-19; Entropy; Lactams; Leucine; Molecular Dynamics Simulation; Nitriles; Proline; SARS-CoV-2

2021
An oral SARS-CoV-2 M
    Science (New York, N.Y.), 2021, Dec-24, Volume: 374, Issue:6575

    Topics: Administration, Oral; Animals; Clinical Trials, Phase I as Topic; Coronavirus; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Therapy, Combination; Humans; Lactams; Leucine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Nitriles; Proline; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors; Virus Replication

2021
The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
    Biotechnology and applied biochemistry, 2022, Volume: 69, Issue:5

    Topics: Adult; Alanine; Amidohydrolases; Antitubercular Agents; Aspartic Acid; Bacterial Proteins; Codon; Cross-Sectional Studies; Humans; Leucine; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Proline; Pyrazinamide; Tuberculosis, Multidrug-Resistant; Young Adult

2022
Antiviral pills could change pandemic's course.
    Science (New York, N.Y.), 2021, Nov-12, Volume: 374, Issue:6569

    Topics: Antiviral Agents; Clinical Trials as Topic; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Tablets

2021
Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan.
    Scientific reports, 2021, 12-06, Volume: 11, Issue:1

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Registries; Sulfonamides; Sustained Virologic Response; Taiwan; Treatment Outcome

2021
Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir.
    Internal medicine (Tokyo, Japan), 2022, May-15, Volume: 61, Issue:10

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Persistent Infection; Phylogeny; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2022
In the age of Omicron variant: Paxlovid raises new hopes of COVID-19 recovery.
    Journal of medical virology, 2022, Volume: 94, Issue:5

    Topics: COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients.
    Medical science monitor : international medical journal of experimental and clinical research, 2022, Jan-01, Volume: 28

    Topics: Administration, Oral; Antibodies, Monoclonal; Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Approval; Drug Repositioning; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; United States; United States Food and Drug Administration

2022
Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management.
    Lancet (London, England), 2022, 01-01, Volume: 399, Issue:10319

    Topics: COVID-19 Drug Treatment; Drug Interactions; Drug Therapy, Combination; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; Viral Protease Inhibitors

2022
A National Strategy for COVID-19 Medical Countermeasures: Vaccines and Therapeutics.
    JAMA, 2022, Jan-18, Volume: 327, Issue:3

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Cytidine; Drug Combinations; Endemic Diseases; Humans; Hydroxylamines; Immunization Schedule; Lactams; Leucine; Nitriles; Population Surveillance; Proline; Ritonavir; SARS-CoV-2; United States

2022
COVID is here to stay: countries must decide how to adapt.
    Nature, 2022, Volume: 601, Issue:7892

    Topics: Adaptation, Psychological; Adult; Child; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Combinations; Endemic Diseases; Humans; Hydroxylamines; Immunity, Herd; Immunization, Secondary; International Cooperation; Lactams; Leucine; Nitriles; Physical Distancing; Proline; Reinfection; Ritonavir; SARS-CoV-2; Social Change; South Africa

2022
COVID-19 Therapeutics for Nonhospitalized Patients.
    JAMA, 2022, 02-15, Volume: 327, Issue:7

    Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; Child; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Female; Health Care Rationing; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Outpatients; Pregnancy; Proline; Ritonavir

2022
Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022, Volume: 79, Issue:4

    Topics: COVID-19; Drug Combinations; Humans; Kidney Transplantation; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Transplant Recipients

2022
[A case of HCV genotype 3b with compensated stage cirrhosis who have two times treatment-experienced with the use of glecaprevir/pibrentasvir combined with sofosbuvir and ribavirin for 16 weeks].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2021, Dec-20, Volume: 29, Issue:12

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Outcome

2021
Why scientists are racing to develop more COVID antivirals.
    Nature, 2022, Volume: 601, Issue:7894

    Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Approval; Drug Combinations; Drug Development; Drug Resistance, Viral; Drug Therapy, Combination; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Medication Adherence; Molecular Targeted Therapy; Mutagenesis; Nitriles; Proline; Public-Private Sector Partnerships; Research Personnel; Ritonavir; SARS-CoV-2

2022
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern.
    Antiviral research, 2022, Volume: 198

    Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Microbial Sensitivity Tests; Nitriles; Proline; RNA-Dependent RNA Polymerase; SARS-CoV-2; Vero Cells; Virus Replication

2022
Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQβ1.
    American journal of human genetics, 2022, 02-03, Volume: 109, Issue:2

    Topics: Acute Disease; Alleles; Amino Acid Substitution; Black People; Female; Gene Expression; Genome-Wide Association Study; Genotype; Hepacivirus; Hepatitis C; HLA-DQ beta-Chains; Host-Pathogen Interactions; Humans; Leucine; Male; Polymorphism, Single Nucleotide; Proline; Protein Isoforms; Remission, Spontaneous; White People

2022
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M
    Reproductive toxicology (Elmsford, N.Y.), 2022, Volume: 108

    Topics: Animals; Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Embryonic Development; Female; Fertility; Infertility; Lactams; Leucine; Male; Nitriles; Pregnancy; Proline; Rabbits; Rats; Rats, Wistar; Ritonavir

2022
COVID-19: LMICs need antivirals as well as vaccines.
    Nature, 2022, Volume: 602, Issue:7895

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Developed Countries; Developing Countries; Drug Costs; Healthcare Disparities; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Licensure; Nitriles; Proline

2022
Sofosbuvir-velpatasvir-voxilaprevir in adolescents 12 to 17 years old with HCV infection.
    Hepatology (Baltimore, Md.), 2022, Volume: 76, Issue:2

    Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Child; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome

2022
Nirmatrelvir-ritonavir for COVID-19.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2022, 02-14, Volume: 194, Issue:6

    Topics: Administration, Oral; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors

2022
Glecaprevir/Pibrentasvir and Renal Dysfunction in Deceased Donor Renal Transplantation: A Case Report.
    Transplantation proceedings, 2022, Volume: 54, Issue:2

    Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2022
Paxlovid for treatment of COVID-19.
    The Medical letter on drugs and therapeutics, 2022, 01-24, Volume: 64, Issue:1642

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Combinations; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; Treatment Outcome; United States; United States Food and Drug Administration

2022
Treatment of COVID-19 in high-risk outpatients.
    The Medical letter on drugs and therapeutics, 2022, Feb-07, Volume: 64, Issue:1643

    Topics: Adenosine Monophosphate; Alanine; Ambulatory Care; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Outpatients; Proline; Ritonavir; Treatment Outcome

2022
High Real-World Sustained Virologic Response Rate with Glecaprevir/Pibrentasvir at a Racially Diverse Urban Academic Medical Center.
    Gut and liver, 2022, 05-15, Volume: 16, Issue:3

    Topics: Academic Medical Centers; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response

2022
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:5

    Topics: Administration, Oral; Animals; Child; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A; Haplorhini; Humans; Lactams; Leucine; Microsomes, Liver; Nitriles; Peptide Hydrolases; Proline; Rats; Ritonavir; SARS-CoV-2

2022
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
    Nature communications, 2022, 02-15, Volume: 13, Issue:1

    Topics: A549 Cells; Administration, Oral; Animals; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Humans; Lactams; Leucine; Mesocricetus; Nitriles; Proline; Respiratory Mucosa; SARS-CoV-2; Vero Cells; Viral Protease Inhibitors; Virus Replication

2022
Audio Interview: A New Antiviral against Covid-19.
    The New England journal of medicine, 2022, 02-17, Volume: 386, Issue:7

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Drug Combinations; Drug Interactions; Female; Humans; Immunity, Active; Immunogenicity, Vaccine; Lactams; Leucine; Male; Nitriles; Proline; Research Design; Ritonavir; Vaccine Efficacy; Viral Protease Inhibitors

2022
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir.
    Bioorganic & medicinal chemistry letters, 2022, 04-15, Volume: 62

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Nitriles; Pandemics; Peptide Hydrolases; Proline; Protease Inhibitors; SARS-CoV-2

2022
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
    Journal of molecular biology, 2022, 05-15, Volume: 434, Issue:9

    Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Design; Drug Resistance, Viral; Fluorine; Halogenation; HCV NS3-4A Protease Inhibitors; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sulfonamides; Viral Proteases

2022
The global COVID-19 treatment divide.
    Lancet (London, England), 2022, 02-26, Volume: 399, Issue:10327

    Topics: COVID-19 Drug Treatment; COVID-19 Testing; Developing Countries; Drug Combinations; Global Health; Health Services Accessibility; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir

2022
Durability of sustained virological response to glecaprevir/pibrentasvir and resistance development: A long-term follow-up study.
    Liver international : official journal of the International Association for the Study of the Liver, 2022, Volume: 42, Issue:6

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response

2022
Hundreds of COVID trials could provide a deluge of new drugs.
    Nature, 2022, Volume: 603, Issue:7899

    Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Neutralizing; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Depsipeptides; Dexamethasone; Drug Combinations; Drug Repositioning; Drug Synergism; Esters; Guanidines; Hospitalization; Host-Pathogen Interactions; Humans; Hydroxylamines; Internationality; Lactams; Leucine; Mice; National Institutes of Health (U.S.); Nitriles; Peptide Elongation Factor 1; Peptides, Cyclic; Proline; Protease Inhibitors; Ritonavir; RNA-Dependent RNA Polymerase; SARS-CoV-2; Serine Endopeptidases; Sodium-Glucose Transporter 2 Inhibitors; United States; Virus Replication

2022
Early clinical experience with nirmatrelvir/ritonavir for the treatment of COVID-19 in solid organ transplant recipients.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022, Volume: 22, Issue:8

    Topics: Adult; Calcineurin Inhibitors; COVID-19 Drug Treatment; Cyclosporine; Graft Rejection; Humans; Immunosuppressive Agents; Lactams; Leucine; Nitriles; Organ Transplantation; Proline; Retrospective Studies; Ritonavir; Sirolimus; Tacrolimus; Transplant Recipients

2022
Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19.
    Clinical pharmacology and therapeutics, 2022, Volume: 111, Issue:6

    Topics: Aminophenols; Benzodioxoles; Chloride Channel Agonists; COVID-19 Drug Treatment; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytochrome P-450 CYP3A; Drug Combinations; Drug Interactions; Humans; Indoles; Lactams; Leucine; Mutation; Nitriles; Proline; Pyrazoles; Pyridines; Pyrrolidines; Quinolines; Quinolones; Ritonavir

2022
Oral Drugs Against COVID-19.
    Deutsches Arzteblatt international, 2022, 04-15, Volume: 119, Issue:15

    Topics: COVID-19; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir

2022
African clinical trial denied access to key COVID drug Paxlovid.
    Nature, 2022, Volume: 604, Issue:7906

    Topics: Africa; Clinical Trials as Topic; COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
    Journal of virology, 2022, 04-27, Volume: 96, Issue:8

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Middle East Respiratory Syndrome Coronavirus; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus

2022
Covid-19: What is the evidence for the antiviral Paxlovid?
    BMJ (Clinical research ed.), 2022, 04-27, Volume: 377

    Topics: Antiviral Agents; COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir

2022
A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition.
    Communications biology, 2022, 04-27, Volume: 5, Issue:1

    Topics: COVID-19; Cysteine Endopeptidases; Humans; Indoles; Lactams; Leucine; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; Pyrrolidinones; SARS-CoV-2; Viral Proteins

2022
PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID-19 patients.
    Clinical and translational science, 2022, Volume: 15, Issue:7

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Endothelial Cells; Humans; Lactams; Leucine; Nitriles; Proline; SARS-CoV-2; United States

2022
Gadoxetic acid-enhanced magnetic resonance imaging predicts hyperbilirubinemia induced by glecaprevir during hepatitis C virus treatment.
    Scientific reports, 2022, 05-12, Volume: 12, Issue:1

    Topics: Aminoisobutyric Acids; Bilirubin; Cyclopropanes; Gadolinium DTPA; Hepacivirus; Hepatitis C; Humans; Hyperbilirubinemia; Lactams, Macrocyclic; Leucine; Magnetic Resonance Imaging; Proline; Quinoxalines; Sulfonamides

2022
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
    Nature, 2022, Volume: 607, Issue:7917

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cricetinae; Cytidine; Drug Combinations; Hydroxylamines; Indazoles; Lactams; Leucine; Mice; Nitriles; Proline; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Triazines; Triazoles

2022
Real-world effectiveness and safety of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir for genotype 6 chronic hepatitis C.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2022, Volume: 121, Issue:11

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzopyrans; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Lipids; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sugars; Sulfonamides; Treatment Outcome

2022
Metabolic characterization of amniotic fluid of fetuses with isolated choroid plexus cyst.
    Journal of perinatal medicine, 2022, Oct-26, Volume: 50, Issue:8

    Topics: Amniotic Fluid; Arginine; Aspartic Acid; Choroid Plexus; Citrulline; Coenzyme A; Cysts; Ethanolamines; Female; Glucose; Humans; Hydroxylysine; Isoleucine; Leucine; Pregnancy; Proline; Ultrasonography, Prenatal; Valine

2022
The future of Paxlovid for COVID-19.
    The Lancet. Respiratory medicine, 2022, Volume: 10, Issue:7

    Topics: COVID-19; Drug Combinations; Forecasting; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir

2022
In Silico Evaluation of Paxlovid's Pharmacometrics for SARS-CoV-2: A Multiscale Approach.
    Viruses, 2022, 05-20, Volume: 14, Issue:5

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT.
    Computational biology and chemistry, 2022, Volume: 99

    Topics: Antiviral Agents; COVID-19; Drug Combinations; Humans; Ivermectin; Lactams; Leucine; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Pandemics; Peptide Hydrolases; Proline; Protease Inhibitors; Ritonavir; SARS-CoV-2; Thermodynamics

2022
Isolation and characterization of novel antihypertensive bioactive peptides from brassica napus and angiotensin-converting enzyme (ace) inhibition potential.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:2(Special)

    Topics: Alanine; Angiotensins; Antihypertensive Agents; Arginine; Brassica napus; Cysteine; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Peptides; Peptidyl-Dipeptidase A; Phenylalanine; Proline; Tandem Mass Spectrometry; Threonine; Tyrosine; Valine

2022
Three more points about Paxlovid for covid-19.
    BMJ (Clinical research ed.), 2022, 06-07, Volume: 377

    Topics: COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
From Positive to Negative to Positive Again-The Mystery of Why COVID-19 Rebounds in Some Patients Who Take Paxlovid.
    JAMA, 2022, 06-28, Volume: 327, Issue:24

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Recurrence; Ritonavir; Viral Protease Inhibitors

2022
High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use.
    The Journal of infection, 2022, Volume: 85, Issue:3

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome

2022
Physiologically-Based Pharmacokinetic Modeling-Guided Dose Management of Oral Anticoagulants when Initiating Nirmatrelvir/Ritonavir (Paxlovid) for COVID-19 Treatment.
    Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:4

    Topics: Aged; Anticoagulants; COVID-19 Drug Treatment; Drug Combinations; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Prospective Studies; Ritonavir; Rivaroxaban; Warfarin

2022
Treatment outcomes of sofosbuvir/velpatasvir/voxilaprevir among NS5A inhibitor-experienced patients with hepatitis C: Real-world data from a multicenter Asian registry.
    Journal of gastroenterology and hepatology, 2022, Volume: 37, Issue:8

    Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Registries; Sofosbuvir; Sulfonamides; Treatment Outcome

2022
Hospitalization and Emergency Department Encounters for COVID-19 After Paxlovid Treatment - California, December 2021-May 2022.
    MMWR. Morbidity and mortality weekly report, 2022, Jun-24, Volume: 71, Issue:25

    Topics: COVID-19; COVID-19 Vaccines; Drug Combinations; Emergency Service, Hospital; Hospitalization; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
Non-responders to sofosbuvir/velpatasvir/voxilaprevir in the treatment of chronic hepatitis C infection.
    Journal of hepatology, 2022, Volume: 77, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzopyrans; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sofosbuvir; Sulfonamides

2022
Covid-19: FDA authorises pharmacists to prescribe Paxlovid.
    BMJ (Clinical research ed.), 2022, 07-08, Volume: 378

    Topics: COVID-19; Drug Combinations; Drug Prescriptions; Humans; Lactams; Leucine; Nitriles; Pharmacists; Proline; Ritonavir

2022
High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use: Some issues.
    The Journal of infection, 2022, Volume: 85, Issue:4

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides

2022
Paxlovid-Tacrolimus Drug-Drug Interaction in a 23-Year-Old Female Kidney Transplant Patient with COVID-19.
    Clinical drug investigation, 2022, Volume: 42, Issue:8

    Topics: Adult; COVID-19; Drug Combinations; Drug Interactions; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Lactams; Leucine; Nitriles; Proline; Ritonavir; Tacrolimus; Young Adult

2022
Interactions listed in the Paxlovid fact sheet, classified according to risks, pharmacological groups, and consequences.
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2022, Volume: 35, Issue:4

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.
    European journal of medicinal chemistry, 2022, Oct-05, Volume: 240

    Topics: Antiviral Agents; Carbamates; Carbutamide; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Nitriles; Proline; Protease Inhibitors; SARS-CoV-2

2022
Paxlovid in patients who are immunocompromised and hospitalised with SARS-CoV-2 infection.
    The Lancet. Infectious diseases, 2022, Volume: 22, Issue:9

    Topics: COVID-19; Drug Combinations; Humans; Immunocompromised Host; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
Successful nasoenteric administration of glecaprevir/pibrentasvir for donor-derived hepatitis C in two young adult heart transplant recipients at a pediatric transplant center.
    Pediatric transplantation, 2022, Volume: 26, Issue:7

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Child; Cyclopropanes; Genotype; Heart Transplantation; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Young Adult

2022
Bad news for Paxlovid? Resistance may be coming.
    Science (New York, N.Y.), 2022, 07-08, Volume: 377, Issue:6602

    Topics: Coronavirus 3C Proteases; COVID-19 Drug Treatment; Drug Combinations; Drug Resistance, Viral; Humans; Lactams; Leucine; Mutation; Nitriles; Proline; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors

2022
Genetic Surveillance of SARS-CoV-2 M
    mBio, 2022, 08-30, Volume: 13, Issue:4

    Topics: Animals; Antiviral Agents; Coronavirus 3C Proteases; COVID-19; Cysteine Endopeptidases; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Pandemics; Proline; Protease Inhibitors; Ritonavir; SARS-CoV-2; Viral Nonstructural Proteins

2022
Rehospitalization, Emergency Visits After Paxlovid Treatment Are Rare.
    JAMA, 2022, 07-26, Volume: 328, Issue:4

    Topics: Antiviral Agents; Drug Combinations; Emergency Service, Hospital; Hospitalization; Humans; Lactams; Leucine; Nitriles; Patient Readmission; Proline; Ritonavir

2022
Real-World Safety, Effectiveness, and Patient-Reported Outcomes in Patients with Chronic Hepatitis C Virus Infection Treated with Glecaprevir/Pibrentasvir: Updated Data from the German Hepatitis C-Registry (DHC-R).
    Viruses, 2022, 07-14, Volume: 14, Issue:7

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Patient Reported Outcome Measures; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Registries; Sulfonamides

2022
COVID-19 update: Prescription of Paxlovid by pharmacists.
    The Medical letter on drugs and therapeutics, 2022, 08-08, Volume: 64, Issue:1656

    Topics: Antiviral Agents; COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Pharmacists; Prescriptions; Proline; Ritonavir

2022
A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer.
    Cancer research, 2022, 10-17, Volume: 82, Issue:20

    Topics: Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Estrogen Receptor alpha; Estrogens; Female; Glutamic Acid; Humans; Leucine; Proline; Proteasome Endopeptidase Complex; Receptors, Estrogen; Transcription Factors

2022
PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.
    Pathology, research and practice, 2022, Volume: 237

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins; CTLA-4 Antigen; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Glutamates; Humans; Leucine; Lung Neoplasms; Proline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Transcription Factors

2022
Comparison of 8- versus 12-weeks of glecaprevir/pibrentasvir for Taiwanese patients with hepatitis C and compensated cirrhosis in a real-world setting.
    PloS one, 2022, Volume: 17, Issue:8

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides

2022
Rapid COVID-19 rebound in a severe COVID-19 patient during 20-day course of Paxlovid.
    The Journal of infection, 2022, Volume: 85, Issue:5

    Topics: COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir

2022
Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge.
    The New England journal of medicine, 2022, 09-01, Volume: 387, Issue:9

    Topics: Adult; Aged; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Hospitalization; Humans; Lactams; Leucine; Middle Aged; Nitriles; Proline; SARS-CoV-2; Treatment Outcome

2022
Characterisation of a Hepatitis C Virus Subtype 2a Cluster in Scottish PWID with a Suboptimal Response to Glecaprevir/Pibrentasvir Treatment.
    Viruses, 2022, 07-29, Volume: 14, Issue:8

    Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Phylogeny; Proline; Pyrrolidines; Quinoxalines; Scotland; Substance Abuse, Intravenous; Sulfonamides

2022
Paxlovid Expiration Dates Extended.
    JAMA, 2022, 09-06, Volume: 328, Issue:9

    Topics: Antiviral Agents; Drug Combinations; Drug Stability; Lactams; Leucine; Nitriles; Proline; Ritonavir; Time Factors

2022
Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites.
    FEMS microbiology ecology, 2022, 10-03, Volume: 98, Issue:10

    Topics: Alanine; Ammonia; Antifungal Agents; Arginine; Aspartic Acid; Bacillus subtilis; Biotransformation; Carbon; Fusarium; Glutamic Acid; Glutamine; Glycine; Isoleucine; Leucine; Linoleic Acids; Linolenic Acids; Microarray Analysis; Nitrogen; Phenotype; Plant Diseases; Proline; RNA, Transfer; Solanum lycopersicum; Valine

2022
Nirmatrelvir-Ritonavir and Viral Load Rebound in Covid-19.
    The New England journal of medicine, 2022, 09-15, Volume: 387, Issue:11

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Recurrence; Ritonavir; Viral Load

2022
Rebound of SARS-CoV-2 Infection after Nirmatrelvir-Ritonavir Treatment.
    The New England journal of medicine, 2022, 09-15, Volume: 387, Issue:11

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Recurrence; Ritonavir; SARS-CoV-2

2022
Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study.
    Physical chemistry chemical physics : PCCP, 2022, Sep-28, Volume: 24, Issue:37

    Topics: Antiviral Agents; Coronavirus 3C Proteases; Cysteine Endopeptidases; Lactams; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Peptide Hydrolases; Proline; SARS-CoV-2

2022
New Data on Paxlovid Reported.
    The American journal of nursing, 2022, 10-01, Volume: 122, Issue:10

    Topics: COVID-19; Drug Combinations; Hospitalization; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Time Factors

2022
Computational analysis and functional characterisation of Tor putitora toll-like receptor 4 with the elucidation of its binding sites for microbial mimicking ligands.
    Fish & shellfish immunology, 2022, Volume: 130

    Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Carps; Cyprinidae; DNA, Complementary; Fish Proteins; Leucine; Ligands; Molecular Docking Simulation; Myeloid Differentiation Factor 88; Pathogen-Associated Molecular Pattern Molecules; Phylogeny; Proline; Receptors, Interleukin-1; Toll-Like Receptor 4; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins

2022
Experience Using Paxlovid for Patients With Coronavirus Disease 2019 in a Resource-Limited Emergency Department.
    Annals of emergency medicine, 2022, Volume: 80, Issue:4

    Topics: COVID-19; Drug Combinations; Emergency Service, Hospital; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
[Determination of free amino acids in Eriocheir sinensis by ultra-high performance liquid chromatography-high resolution mass spectrometry].
    Se pu = Chinese journal of chromatography, 2022, Volume: 40, Issue:9

    Topics: Acetonitriles; Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Brachyura; Chromatography, High Pressure Liquid; Cystine; Formates; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Mass Spectrometry; Methionine; Perchlorates; Phenylalanine; Polypropylenes; Proline; Serine; Solvents; Threonine; Tyrosine; Valine; Water

2022
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adenocarcinoma of Lung; Computational Biology; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Interleukin-17; Interleukin-6; Lactams; Leucine; Lung Neoplasms; Molecular Docking Simulation; Network Pharmacology; Nitriles; Proline; Receptors, Cytokine; Ritonavir; SARS-CoV-2; United States

2022
[Cell metabolomics study of ginkgo flavone aglycone combined with doxorubicin against liver cancer in synergy].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:18

    Topics: Arginine; beta-Alanine; Doxorubicin; Flavones; Ginkgo biloba; Glutathione; Humans; Isoleucine; Leucine; Liver Neoplasms; Metabolomics; Phenylalanine; Proline; Tandem Mass Spectrometry; Tyrosine; Valine

2022
A glycogen storage disease type 1a patient with type 2 diabetes.
    BMC medical genomics, 2022, 09-27, Volume: 15, Issue:1

    Topics: Adenoma; Adult; Diabetes Mellitus, Type 2; Electrolytes; Female; Glucose; Glucose-6-Phosphatase; Glycogen Storage Disease Type I; Humans; Insulins; Leucine; Proline; Starch

2022
Intestinal metabolomics of juvenile lenok (Brachymystax lenok) in response to heat stress.
    Fish physiology and biochemistry, 2022, Volume: 48, Issue:5

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Acetylcarnitine; Animals; Aspartic Acid; Erucic Acids; Glucose; Glutamine; Heat-Shock Response; Histidine; Intestines; Lactates; Leucine; Methionine; Oxylipins; Palmitoylcarnitine; Phenylalanine; Phosphatidylcholines; Phosphorylcholine; Proline; Salmonidae; Tandem Mass Spectrometry; Tryptophan; Tyrosine

2022
Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir.
    Medical science monitor : international medical journal of experimental and clinical research, 2022, Oct-01, Volume: 28

    Topics: Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2

2022
Paxlovid Drug Interaction Screening Checklist Updated.
    JAMA, 2022, 10-04, Volume: 328, Issue:13

    Topics: Antiviral Agents; Checklist; Drug Combinations; Drug Interactions; Lactams; Leucine; Mass Screening; Nitriles; Proline; Ritonavir

2022
[Serological Characteristics and Molecular Biological Mechanism of AEL.02 Subtype].
    Zhongguo shi yan xue ye xue za zhi, 2022, Volume: 30, Issue:5

    Topics: ABO Blood-Group System; Alleles; Genotype; Isoleucine; Leucine; Phenotype; Phenylalanine; Proline

2022
Formulation, Characterisation and Evaluation of the Antihypertensive Peptides, Isoleucine-Proline-Proline and Leucine-Lysine-Proline in Chitosan Nanoparticles Coated with Zein for Oral Drug Delivery.
    International journal of molecular sciences, 2022, Sep-22, Volume: 23, Issue:19

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Caco-2 Cells; Chitosan; Drug Carriers; Humans; Leucine; Lysine; Nanoparticles; Oligopeptides; Particle Size; Peptides; Proline; Rats; Rats, Inbred SHR; Zein

2022
    Nutrients, 2022, Oct-01, Volume: 14, Issue:19

    Topics: Agaricales; Animals; Antioxidants; Arginine; Biomarkers; Diet, High-Fat; Fucose; Galactose; Glucose; Glycerides; Glycerol; Isoleucine; Leucine; Lipid Metabolism; Lipid Metabolism Disorders; Liver; Mannose; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phospholipids; Polysaccharides; Proline; Spectroscopy, Fourier Transform Infrared; Steroids; Valine; Xylose

2022
Expanding the Landscape of Amino Acid-Rich Antimicrobial Peptides: Definition, Deployment in Nature, Implications for Peptide Design and Therapeutic Potential.
    International journal of molecular sciences, 2022, Oct-25, Volume: 23, Issue:21

    Topics: Amino Acid Sequence; Amino Acids; Animals; Antimicrobial Peptides; Arginine; Leucine; Mammals; Peptide Fragments; Peptides; Proline; Trypsin

2022
Metabolomics profiling of seminal plasma in obesity-induced asthenozoospermia.
    Andrology, 2023, Volume: 11, Issue:7

    Topics: Aconitic Acid; Alanine; Asthenozoospermia; Citrulline; Glucose; Glutamic Acid; Glycine; Humans; Leucine; Lysine; Male; Metabolomics; Phenylalanine; Proline; Semen; Serine; Succinic Acid; Threonine; Tyrosine; Valine

2023
Plasma amino acids by age and gender in Hangzhou, Eastern China.
    Asia Pacific journal of clinical nutrition, 2023, Volume: 32, Issue:2

    Topics: Amino Acids; Arginine; Chromatography, Liquid; Female; Glycine; Humans; Isoleucine; Leucine; Male; Phenylalanine; Proline; Tandem Mass Spectrometry; Valine

2023
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.
    Nature, 2023, Volume: 622, Issue:7982

    Topics: Antiviral Agents; Binding Sites; Coronavirus 3C Proteases; COVID-19; Drug Design; Drug Resistance, Viral; Humans; Lactams; Leucine; Mutation; Nitriles; Proline; SARS-CoV-2; Substrate Specificity; Virus Replication

2023
Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in rats with cerebral ischemia-reperfusion injury.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 2

    Topics: Animals; Biomarkers; Brain Ischemia; Cerebral Infarction; China; Chromatography, High Pressure Liquid; Erigeron; Ischemic Stroke; Leucine; Metabolomics; Molecular Docking Simulation; Proline; Rats; Reperfusion Injury; Tandem Mass Spectrometry

2024
Intraspecific genetic lineages of a marine mussel show behavioural divergence when exposed to microplastic leachates.
    Environmental pollution (Barking, Essex : 1987), 2024, Jan-01, Volume: 340, Issue:Pt 1

    Topics: Adult; Animals; Cysteine; Humans; Leucine; Microplastics; Mytilus; Plastics; Proline

2024