proline has been researched along with leucine in 1661 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 680 (40.94) | 18.7374 |
| 1990's | 174 (10.48) | 18.2507 |
| 2000's | 265 (15.95) | 29.6817 |
| 2010's | 325 (19.57) | 24.3611 |
| 2020's | 217 (13.06) | 2.80 |
| Authors | Studies |
|---|---|
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Brandsch, M; Gebauer, S; Laug, L; Schäfer, S; Thondorf, I; Voigt, V; Zebisch, K | 1 |
| Bartnik, E; Piotrowska, M; Stepień, PP; Zakrzewska, E | 1 |
| Burrill, PH; Lerner, J; Sattelmeyer, PA | 1 |
| Dell, J; Toome, V; Wegrzynski, B | 1 |
| Lichtman, MA; Peck, WA; Rockwell, LH | 1 |
| Björkman, S; Castensson, S; Lindeke, B; Sievertsson, H | 1 |
| Chen, RF; Maly, M; Smith, PD | 1 |
| Higashijima, T; Miyazawa, T; Miyoshi, M; Tasumi, M | 1 |
| Kutzman, RS; Roberts, JF | 1 |
| Barber, PC; Field, PM | 1 |
| Kleinkauf, H; Vater, J | 1 |
| Minckler, DS; Tso, MO | 1 |
| Dabrowa, N; Howard, DH | 1 |
| Conrad, LC; Pfaff, DW | 2 |
| Beitz, AJ | 1 |
| Cowan, WM; Saper, CB; Swanson, LW | 1 |
| Cowan, WM; Loewy, AD; Saper, CB; Swanson, LW | 1 |
| Minckler, DS; Tso, MO; Zimmerman, LE | 1 |
| Agranoff, BW; Heacock, AM | 1 |
| Hall, WC; Skeen, LC | 1 |
| Cowan, WM; Swanson, LW | 1 |
| Coulter, JD; Jones, EG | 1 |
| Künzle, H | 2 |
| Gross, GW; Kreutzberg, GW | 1 |
| Gross, GW; Kreutzberg, GW; Krygier-Brévart, V; Weiss, DG | 1 |
| Casseday, JH; Jones, DR | 1 |
| Bonke, BA; Bonke, D; Scheich, H | 1 |
| Hashikawa, T; Kawamura, K | 1 |
| Fallon, JH; Moore, RY | 1 |
| Engström, C; Jontell, M; Linde, A | 1 |
| Kendall, A; Lehmann, H; Oune, N; Wiltshire, B; Young, S | 1 |
| Dingle, JT; Meikle, MC; Reynolds, JJ; Sellers, A | 1 |
| Kilroe-Smith, TA; McLoughlin, JL | 1 |
| Hajek, AS; Solursh, M | 1 |
| Anraku, Y; Kin, E | 1 |
| Baker, RA; Hubbard, JS; Rinehart, CA | 1 |
| Hilf, R; Hissin, PJ | 2 |
| Lee, SG; Lipmann, F | 1 |
| Leushner, J; Pasternak, J | 1 |
| Frey, KL; Haralson, MA; Mitchell, WM | 1 |
| Renvall, S | 1 |
| Hempel, K; Romen, W | 1 |
| Adams, E; Heacock, AM | 1 |
| Basset, P; Beuzard, Y; Braconnier, F; Caburi, J; el Gammal, H; Martin, L; Oudard, JL; Thillet, J | 1 |
| Gacon, G; Jones, RT; Koler, RD; Labie, D; Wajcman, H | 1 |
| Sodek, J | 1 |
| Ashman, PU; Newport, GR; Page, CR; Seed, JR; Stibbs, HH | 1 |
| Kniewald, Z; Kordić, D | 1 |
| Desai, SM; Weiss, SB | 1 |
| Calvo, JM; Davis, MG | 1 |
| Hatfield, GW; Lawther, RP; Oxender, DL; Quay, SC | 1 |
| Herrington, MB; Kapoor, V; Newman, EB; Tam, A | 1 |
| Carter, BL; Ehrhardt, CW; Johnston, GC; Lorincz, A | 1 |
| Scarpulla, RC; Soffer, RL | 1 |
| Robertson, JH; Wheatley, DN | 1 |
| Downing, SJ; Kowaloff, EM; Phang, JM; Smith, RJ; Valle, D | 1 |
| Cohen, P; Convert, O; Di Bello, C; Griffin, JH; Nicolas, P | 1 |
| Kaplan, J; Murray, LW; Rowland, FN; Tanzer, ML | 1 |
| Milsom, JP; Morgan, MY; Sherlock, S | 1 |
| Davidson, CS; Fernstrom, JD; Hammarstrom-Wiklund, B; Munro, HN; Rand, WM; Wurtman, RJ | 2 |
| Bailey, RS; Fried, B | 1 |
| Dall'asta, V; Gazzola, GC; Guidotti, GG | 2 |
| Habowsky, J; Lupulescu, A | 1 |
| Türet, S | 1 |
| Das, HK; Subrahmanyam, CS | 1 |
| Pantyukhova, VV; Pekhov, AP; Rudneva, SN | 1 |
| Cruce, JA | 1 |
| Vary, JC | 1 |
| Hoare, DS; Hoare, L; Patel, R; Taylor, BF | 1 |
| Butler, M; Capindale, JB | 1 |
| Anda, LP; Dotchev, D; Liappis, N | 1 |
| Hempel, K; Romen, W; Schultze, B | 1 |
| Deutsch, HF; Fett, JW | 1 |
| Goldman, PS; Nauta, WJ | 1 |
| Bayley, HS; Chavez, ER | 1 |
| Askenasi, R; Gregoire, F | 1 |
| Lupulescu, AP | 1 |
| Nakayama, T; Narita, K | 1 |
| Iwase, H; Murai, A | 1 |
| Robinson, JH | 1 |
| Matsuoka, M; Miyaji, T; Ohba, Y; Sugiura, T; Sugiyama, K; Suzuki, T | 1 |
| Berg, A; Keul, J | 1 |
| Brack, A | 1 |
| Berkley, KJ; Graham, J; Jones, EG | 1 |
| Nakayama, T; Narita, K; Ogata, K | 1 |
| Grathwohl, C; Wüthrich, K | 1 |
| Deslauriers, R; Grzonka, Z; Walter, R | 1 |
| Granger, AS; Kowaloff, EM; Phang, JM | 1 |
| Corley, CC; Gravely, M; Huisman, TH; Milner, PF; Pomeroy, WL; Wilson, JB | 1 |
| Counahan, R; Cox, BD; El-Bishti, M; Ogg, CS | 1 |
| Horváth, M; Mestyán, J; Schultz, K; Soltész, G | 1 |
| Baccetti, B; Burrini, AG; Pallini, V | 1 |
| Lowe, NR; Robinson, C; Weatherell, JA | 1 |
| Lee, M; Oxender, DL; Robbins, JC | 1 |
| Barak, Z; Gilbarg, C | 1 |
| Anraku, Y; Goto, F; Kin, E | 1 |
| Kirshner, N; Schramm, M; Wallach, D | 1 |
| Cruce, JA; Cruce, WL | 1 |
| Del Pra, A; Scatturin, A; Tamburro, AM | 1 |
| Baum, BJ; Franzblau, C; Johnson, LS; Troxler, RF | 1 |
| Coy, DH; Dupont, A; Kastin, AJ; Labrie, F; Pelletier, G; Puviani, R; Schally, AV | 1 |
| Dessauer, PL; Hubbard, M; Huisman, TH; Lindeman, JG; Wilson, JB; Winton, EF; Wrightstone, RN | 1 |
| Bhatnager, RS; Rapaka, RS | 1 |
| Havran, RT; Roy, J; Schwartz, IL; Walter, R | 1 |
| Jones, EG | 1 |
| Price, JL; Sprich, WW | 1 |
| Bordignon, E; Scatturin, A; Tamburro, AM; Vidali, G | 1 |
| Marks, N; Neidle, A; Walter, R | 1 |
| Eisenbach, GM; Stolte, H; Weise, M | 1 |
| Feldherr, CM | 1 |
| Berkley, KJ | 1 |
| Ivano, E; Kr"steva, A; Lozanova, L; Nedkov-Bratanova, N; Nikolov, N | 1 |
| Lupulescu, A | 1 |
| Bordignon, E; Del Pra, A; Scatturin, A; Tamburro, AM | 1 |
| Fendler, JH; Nagyvary, J; Nome, F | 1 |
| Modin, R; Nordgren, T | 1 |
| Guadalix, FJ; Ruiz, MC | 1 |
| Agosti, S; Baffico, M; Cao, A; Melevendi, C; Murru, S; Pirastu, M; Poddie, D; Sciarratta, GV | 1 |
| Bijvoet, SM; Hayden, MR | 1 |
| Vilsen, B | 1 |
| Adefarati, AA; Hensens, OD; Jones, ET; Tkacz, JS | 1 |
| Desviat, LR; Pérez, B; Ugarte, M | 1 |
| Hasegawa, Y; Kayahara, T; Kohno, M; Nakano, K; Sasaki, K; Tokushige, A | 1 |
| Buchberg, AM; Kosaras, B; Moskow, JJ; Shooter, EM; Sidman, RL; Snipes, GJ; Suter, U; Welcher, AA | 1 |
| Bale, SJ; Chipev, CC; Compton, JG; DiGiovanna, JJ; Korge, BP; Markova, N; Steinert, PM | 1 |
| Baraitser, M; Malcolm, S; Rutland, P; Strautnieks, S; Winter, RM | 1 |
| Desnick, RJ; Levran, O; Schuchman, EH | 1 |
| Buddington, RK; Puchal, AA; Vega, YM | 1 |
| Barrow, CJ; Nakanishi, K; Tachibana, K | 1 |
| Colbert, JT; Held, BM; John, I; Wang, H; Wurtele, ES | 1 |
| Barz, D; Eckhardt, CM; Kiefel, V; Kuijpers, RW; Ouwehand, WH; Taaning, E; Termijtelen, A; von dem Borne, AE; Waters, AH; Zupanska, B | 1 |
| Apfelstedt-Sylla, E; Gal, A; Horn, M; Kunisch, M; Rüther, K; Zrenner, E | 1 |
| Brennan, SO; George, PM; Higuchi, R; Myles, T; Symmans, WA; Williamson, D | 1 |
| Caso, R; Dawes, J; Lane, DA; Morris, HR; Olds, RJ; Panico, M; Sas, G; Thein, SL | 1 |
| Kaji, T; Kawashima, T; Sakamoto, M; Yamamoto, C | 1 |
| Anderson, AG; Hermans, J; Yun, RH | 1 |
| Naess, O; Nicolaissen, B; Ringvold, A | 1 |
| Hsiao, K; Prusiner, SB | 1 |
| DeArmond, SJ; Foster, D; Groth, D; Hsiao, K; Prusiner, SB; Scott, M; Serban, H | 1 |
| Graybiel, AM; Ragsdale, CW | 2 |
| Glickstein, M; May, J; Mercier, B | 1 |
| DaRosso, R; Espinola, R; Flug, F; Karpatkin, S; Liu, LX; Nardi, M; SinQuee, C | 1 |
| Tanno, Y; Tsuji, S; Yoneda, M | 1 |
| Feig, S; Harting, JK; Van Lieshout, DP | 1 |
| Burke, JF; Jaksic, T; Wagner, DA; Young, VR | 1 |
| Gudnason, V; Humphries, S; King-Underwood, L; Knight, B; Patel, D; Seed, M; Soutar, A | 1 |
| Killeen, AA; Orr, HT; Sane, KS | 1 |
| Berg, A; Goldberg, L; Grabowski, GA; Grace, ME; He, GS; Horowitz, M | 1 |
| Amioka, H; Dojo, S; Hayashi, K; Hiraoka, M; Hirata, Y; Kurushima, H; Nakashima, K; Nishio, E; Ohtani, H; Saeki, M | 1 |
| Barbato, G; Bax, A; Ikura, M; Kay, LE; Krinks, M; Spera, S | 1 |
| Dekker, JJ; Goldman-Rakic, PS; Schwartz, ML | 1 |
| Klinkhamer, MP; Krans, HM; Maassen, JA; Möller, W; Van der Vorm, ER; Van der Zon, GC | 1 |
| Asakura, H; Iwanaga, S; Kajiyama, S; Kumabashiri, I; Matsuda, T; Miyata, T; Saito, M; Uotani, C | 1 |
| Masuno, M; Orii, T; Sukegawa, K; Tomatsu, S | 1 |
| Béliveau, R; Demeule, M; Jetté, M; Potier, M | 1 |
| Chen, SA; Pompon, D; Zhou, DJ | 1 |
| Maeda, M; Yoshida, A | 1 |
| Berson, EL; Dryja, TP; Rosner, B; Sandberg, MA; Weigel-DiFranco, C | 1 |
| Hamm, G; Lemmen, C; Willershausen-Zönnchen, B | 1 |
| Asakura, S; Hirata, H; Matsuda, M; Okuma, M; Yamazumi, K; Yoshida, N | 1 |
| Dumic, M; New, MI; Speiser, PW; Tusie-Luna, MT; White, PC | 1 |
| Munck, BG; Munck, LK | 1 |
| Mason, JI; Mathew, PA; Sanders, D; Trant, JM; Waterman, MR | 1 |
| Charbonneau, M; Mori, Y; Refetoff, S; Takeda, K | 1 |
| Baranton, G; Margarita, D; Richaud, C; Saint Girons, I | 1 |
| Courtois, Y; Galera, P; Haloui, Z; Laurent, M; Pujol, JP | 1 |
| Bellon, G; Borel, JP; Gillery, P; Maquart, FX; Wegrowski, Y | 1 |
| Jaksic, T; Wagner, DA; Young, VR | 1 |
| Bolen, FA; Hammerschlag, R; Stone, GC | 1 |
| Brauth, SE; Kitt, CA | 1 |
| Berkley, KJ; Contos, N | 1 |
| Koike, H | 1 |
| Wild, JM | 1 |
| Giguere, M; Goldman-Rakic, PS | 1 |
| Groen, NA; Klinkhamer, MP; Krans, HM; Lindhout, D; Maassen, JA; Möller, W; Sandkuyl, LA; van der Zon, GC | 1 |
| Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z | 1 |
| Brody, LC; Engelhardt, JF; Kaiser-Kupfer, M; Looney, JE; Mitchell, GA; Obie, C; Patel, AS; Sipila, I; Steel, G; Wong, C | 1 |
| Byers, MR; Dong, WK | 1 |
| Aster, RH; Derbes, RS; Newman, PJ | 1 |
| Ahl, PL; Khorana, HG; Mogi, T; Rothschild, KJ; Stern, LJ | 1 |
| Bowie, JU; Patel, DJ; Sauer, RT; Vershon, AK; Zagorski, MG | 1 |
| Cooper, HM; Magnin, M; Mick, G | 1 |
| Bayreuther, K; Pfleiderer, G; Rodemann, HP | 1 |
| Doh-ura, K; Kitamoto, T; Sakaki, Y; Sasaki, H; Tateishi, J | 1 |
| Crystal, RG; Frants, RR; Hofker, MH; Klasen, EC; Kramps, JA; Nelen, M; Nukiwa, T; van Paassen, HM | 1 |
| Delaunay, J; Francina, A; Galacteros, F; Rosa, J; Wajcman, H | 1 |
| Beckstead, RM; Bromley, S; Gracco, C; Royce, GJ | 1 |
| Beckstead, RM; Segal, RL | 1 |
| Fukumaki, Y; Kobayashi, Y; Komatsu, N; Miura, Y; Miyaji, T; Ohba, Y | 1 |
| Harms, E; Umbarger, HE | 1 |
| Battaglini, PP; Galletti, C; Maioli, MG; Squatrito, S | 1 |
| Yee, JA | 1 |
| Lowe, PN; Rowe, AF | 1 |
| Absher, PM; Arnold, J; Hildebran, JN; Low, RB; Stirewalt, WS | 1 |
| Borghetti, AF; Gandolfi, SA; Petronini, PG | 1 |
| Albrich, JM; Callahan, KB; Gilbaugh, JH; Hurst, JK | 1 |
| Cami, B; Chippaux, M; Fons, M; Patte, JC | 1 |
| Chang, JY; Tran, TH | 1 |
| Arme, C; Jeffs, SA | 1 |
| Carter, S; Diamond, J; Hughes, M; Karasov, W; Phan, D; Solberg, D; Zollman, F | 1 |
| Kato, H; Naito, H; Nam, TJ; Noguchi, T | 1 |
| François, C; Percheron, G; Tandé, D; Yelnik, J | 1 |
| Sakai, ST | 1 |
| Gentz, R; Ibrahimi, I | 1 |
| Cohen, DH; Gamlin, PD | 1 |
| Pandya, DN; Yeterian, EH | 1 |
| Blanks, RH; Giolli, RA; Torigoe, Y | 1 |
| Fómez-Pinilla, F; Hovda, DA; Sonnier, BJ; Villablanca, JR | 1 |
| Henderson, J; Kaye, M | 1 |
| Barile, FA; Bienkowski, RS; Ripley-Rouzier, C; Siddiqi, ZE | 1 |
| Franzblau, C; Goldstein, RH; Meeker, D; Polgar, P; Sakowski, S | 1 |
| Berkley, KJ; Contos, N; Elam, JS | 1 |
| Dennis, BJ; Kerr, DI; Krantis, A | 1 |
| Pandya, DN; Seltzer, B | 2 |
| Grigonis, AM; Murphy, EH; Pearson, HE | 1 |
| Barrett, J; Grantham, BD | 1 |
| Karten, HJ; Reiner, A | 1 |
| Frick, L; Wolfenden, R | 1 |
| Feldman, JL; Loewy, AD; Speck, DF | 1 |
| Brunette, DM; Hasegawa, S; Saito, S; Sato, S; Suzuki, Y | 1 |
| Chang, SD; Diamond, JM; Hughes, M; Karasov, WH; Solberg, DH; Stein, ED | 1 |
| Pandya, DN; Rockland, KS | 1 |
| Carvajal, N; Cederbaum, SD | 1 |
| Behan, M | 1 |
| Adams, WC; Frieden, EH | 1 |
| Belzberg, H; Coleman, B; Pittiruti, M; Placko, R; Sganga, G; Siegel, JH; Wedel, S; Wiles, CE | 1 |
| Oliver, DL | 1 |
| Andersen, RA; Asanuma, C; Cowan, WM | 1 |
| Kuznetsova, VS; Orlova, TI; Silaev, AB | 1 |
| Forman, DS; Grafstein, B; McEwen, BS | 1 |
| Caplan, AI | 2 |
| Jacob, J | 1 |
| Smith, BH | 1 |
| Alvarez, J; Püschel, M | 1 |
| Karlsson, JO; Sjöstrand, J | 1 |
| Grafstein, B; Ingoglia, NA; Murray, M | 1 |
| Itano, HA; Kawasaki, I | 1 |
| Lenn, NJ; Moore, RY | 1 |
| Copeland, T; Gilden, RV; Oroszlan, S; Summers, M | 1 |
| Hall, MD; Hyde, RD; Lehmann, H; Wiltshire, BG | 1 |
| Grafstein, B; Laureno, R | 1 |
| Schafer, R | 1 |
| Meier, RE | 1 |
| Cowan, WM; Crossland, WJ; Kelly, JP | 1 |
| Moore, RY | 1 |
| Kirschbaum, JB | 1 |
| Bryce, GF | 1 |
| Karlson, JO; Marchisio, PC; Sjöstrand, J | 1 |
| Cuénod, M; Künzle, H | 1 |
| Laland, SG; Pass, L; Zimmer, TL | 1 |
| Imae, Y; Kambe, M; Kurahashi, K | 1 |
| McClure, WO; Schlichter, DJ | 1 |
| Agulnek, MA; Cowan, WM; Price, JL; Wann, DF | 1 |
| Carpenter, MB; Pierson, RJ | 1 |
| Agranoff, BW; Elam, JS; Neale, EA; Neale, JH | 1 |
| Balcar, VJ; Johnston, GA | 1 |
| Hare, JF; Kennedy, EP; Olden, K | 1 |
| Burrill, P; Lerner, J; Miller, DS | 1 |
| Bentley, PH; Gregory, RA; Grossman, MI; Tracy, HJ | 1 |
| De Lorenzo, F; Givol, D | 1 |
| Diamond, S; Hansen, S; Perry, TL; Stedman, D | 1 |
| Boos, W; Shen, BH | 1 |
| Chase, TN; Lipton, MA; Morris, CE; Woods, AC | 1 |
| Castensson, S; Lindeke, B; Sievertsson, H; Sum, CY | 1 |
| Banerjee, AB; Bhattacharyya, SK | 1 |
| Karcher-Djuricic, V; Moullec, N; Ruch, JV | 1 |
| Karcher-Djuricic, V; Ruch, JV | 1 |
| Miyazawa, Y; Sekine, T; Yamaguchi, M | 1 |
| Hansen, S; Lesk, D; Perry, TL | 1 |
| Boyer, PD; Klein, WL | 1 |
| Meier, S; Solursh, M | 1 |
| Elam, JS | 1 |
| Lal, D; Schedl, HP | 1 |
| Reiter, RS; Solursh, M; Vaerewyck, SA | 1 |
| Fabre, M; Karcher-Djuricic, V; Ruch, JV; Stäubli, A | 1 |
| Shapiro, BM; Stadtman, ER | 1 |
| Manahan, J; Mandl, I | 2 |
| Borghetti, AF; Guidotti, GG; Lüneburg, B | 1 |
| Gregson, N; Hamberger, A; Lehninger, AL | 1 |
| Hussa, RO; Winnick, M; Winnick, T | 1 |
| Laufs, R; Walker, W | 1 |
| Gevers, W; Kleinkauf, H | 1 |
| Fujikawa, K; Imae, Y; Kambe, M; Kurahashi, K; Mori, K; Sakamoto, Y; Sato, E; Takahashi, H; Yamada, M | 1 |
| Kaback, HR; Milner, LS | 1 |
| Downing, SJ; Phang, JM; Weiss, IW | 1 |
| Lanks, KW; Weinstein, IB | 1 |
| von Bruchhausen, F | 1 |
| Jaeger, E; Schönsteiner-Altmann, G; Wünsch, E | 1 |
| Morgan, K; Phang, JM; Weiss, IW | 1 |
| Marks, N; Walter, R | 1 |
| Iwaki, M; Kaji, E; Kanda, M; Saito, Y; Shimura, K | 1 |
| Hamberger, L; Herlitz, H; Sjögren, A | 1 |
| Bayliss, ME; Prescott, JM; Wilkes, SH | 1 |
| Gnarra, DJ; Green, D; Honig, GR; Mason, RG; Maurer, HS; Shamsuddin, M; Vida, LN | 1 |
| Brecher, AS; Simmons, WH | 1 |
| Perdue, JF; Wray, VP | 1 |
| Heinemann, S; Humphreys, S; Patrick, J; Schubert, D; Tarikas, H | 1 |
| Hogan, BL; Murden, S | 1 |
| Crippa, PR; Tedeschi, RA; Vecli, A | 1 |
| Felix, D; Künzle, H | 1 |
| Barrett, JC; Miller, PS; Ts'o, PO | 1 |
| Ikenaka, T; Murao, S; Nabeshima, Y; Odani, S; Sakai, M; Sato, S | 1 |
| Anderer, FA; Wittmann, HG; Wittmann-Liebold, B | 1 |
| Chandra, P; Lingens, F; Süssmuth, R; Wacker, A | 1 |
| Jaenicke, R; Jockusch, H; Koberstein, R | 1 |
| Nishikimi, M; Oishi, N; Takai, A; Yagi, K | 2 |
| Guilbault, GG; Hieserman, JE | 1 |
| Kastin, AJ; Nair, RM; Schally, AV | 1 |
| Kuhn, J; Somerville, RL | 1 |
| Barooshian, AV; Greenwood, JM; Harris, WG; Lautenschleger, MF | 1 |
| Burrill, P; Lerner, J | 1 |
| Galoyan, A; Grynbaum, A; Lajtha, A; Marks, N | 1 |
| Caruthers, JS; Lorenzo, AV | 1 |
| Kitagawa, H; Mori, T; Riggs, TR | 1 |
| Cowan, WM; Jones, EG; Swanson, LW | 1 |
| Edwards, SB; Palmer, LA; Rosenquist, AC | 1 |
| Brown, AS; Troxler, RF | 1 |
| Dancis, J; Schneider, H | 1 |
| Fifkova, E; Van Harreveld, A | 1 |
| Lindig, OH; Mitlin, N; Thompson, AC; Wiygul, G | 1 |
| Wajgt, A; Wender, M; Zgorzalewicz, B | 1 |
| Shotts, WJ; Sievers, AJ | 1 |
| Crossley, AC; Evans, PD | 1 |
| el-Sewefy, AZ; Hegazi, SM | 1 |
| Palau, J; Puigdoménech, P | 1 |
| Bonner, WA | 2 |
| Friedmann, N; Miller, SL; Ring, D; Wolman, Y | 1 |
| Arregui, A; Bennett, JP; Logan, WJ; Snyder, SH | 1 |
| Wright, EM | 1 |
| Clark, DE; Grant, NH; Rosanoff, EI | 1 |
| Scalia, F | 1 |
| Flickinger, RA; Rollins, JW | 1 |
| De Haan, PG; Hoekstra, WP; Verhoef, C | 1 |
| Arimura, A; Hashimoto, T; Kaneko, T; Kenmochi, Y; Oka, H; Saito, S; Schally, AV; Yanaihara, C; Yanaihara, N | 1 |
| Nair, RM; Schally, AV | 1 |
| Arimura, A; Hashimoto, T; Kaneko, T; Schally, AV; Tsuji, K; Yanaihara, C; Yanihara, N | 1 |
| Ferrell, L; Kastin, AJ; Miller, MC; Schally, AV | 1 |
| Miller, EJ | 1 |
| Sunde, ML | 1 |
| Adelberg, EA; Bergquist, PL | 1 |
| Morris, H; Schlesinger, MJ | 1 |
| Gylfe, E | 1 |
| Boyle, SM; Sells, BH | 1 |
| Dworsky, P | 1 |
| Kemper, J | 2 |
| Ozeki, H; Sakano, H; Shimura, Y | 1 |
| Christensen, HN; Quay, S | 1 |
| Halpern, YS | 1 |
| Cowan, WM; Hendrickson, AE; Wagoner, N | 1 |
| Fekl, W | 1 |
| Anderson, MS; Kastin, AJ; Plotnikoff, NP; Schally, AV | 1 |
| Jost, R; Masson, A; Zuber, H | 1 |
| Barbeau, A; Kastin, AJ | 1 |
| Bradbury, JH; Ley, KF | 1 |
| Alimov, IIu; Iur'eva, EA; Marchenko, ZM | 1 |
| Okano, T; Sato, Y | 1 |
| Tobin, MC | 1 |
| Labie, D; Solal, MC | 1 |
| Cheeseman, CI; Smyth, DH | 1 |
| Betz, AL; Gilboe, DD | 1 |
| Kastin, AJ; Nair, RM; Redding, TW; Schally, AV | 1 |
| Exss, RE; Summer, GK | 1 |
| Caspary, WF; Creutzfeldt, W | 1 |
| Denamur, R; Gaye, P; Houdebine, L | 1 |
| Gruber, L; Harris, JE | 1 |
| Johnson, DE; Sellinger, OZ | 1 |
| Graybiel, AM; Lasek, RJ; Nauta, HJ; Nauta, WJ | 1 |
| Balsamo, J; Brentani, R; Marques, N; Myiashita, M; Stolf, AM; Wang, L | 1 |
| Kuznar, J; Magaña-Schwencke, N; Schwencke, J | 1 |
| Friedman, E; Friedman, J; Gershon, S | 1 |
| Glasel, JA; Hruby, VJ; McKelvy, JF; Spatola, AF | 1 |
| Trayhurn, P; van Heyningen, R | 1 |
| Hook, DJ; Vining, LC | 1 |
| Beuttel, SC; Eisenbarth, GS; Lebovitz, HE | 1 |
| Geerstsen, EA; Gibbons, GC; Strobaek, S | 1 |
| Harik, SI; North, RB; Snyder, SH | 1 |
| Gruhn, K | 1 |
| Rea, C; Reynolds, R; Segal, S | 1 |
| De Coen, JL; Ralston, E | 1 |
| Kent, C; Williams, MA | 1 |
| Cowan, WM; Crossland, WJ; Kelly, JP; Rogers, LA | 1 |
| Cuénod, M; Meier, RE; Mihailovic, J | 1 |
| Bergström, J; Fürst, P; Norée, LO; Vinnars, E | 1 |
| Allen, NK; Baker, DH | 1 |
| Barrett, FM | 1 |
| Kastin, AJ; Plotnikoff, NP | 1 |
| Bartsocas, CS; Crawford, JD; Thier, SO | 1 |
| Piechowski, A; Wender, M; Zgorzalewicz, B | 1 |
| Bergeron, M; Dubord, L | 1 |
| Gröger, D; Johne, S | 2 |
| Cutroneo, KR; Prichard, PM; Staton, GW | 1 |
| Kolaskar, AS; Ramachandran, GN; Ramakrishnan, C; Sasisekharan, V | 1 |
| Kastin, AJ; Minard, FN; Plotnikoff, NP | 1 |
| Dworak, W; Tustanowski, S | 2 |
| Mizuno, S; Nitta, K; Umezawa, H | 1 |
| Shaw, MK | 1 |
| Chow, RB; Kassel, B | 1 |
| Lin, YC; Tanaka, N | 1 |
| Milstein, CP | 1 |
| Koehn, PV; Perlmann, GE | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Ekert, B; Monier, R; Tordjman, A | 1 |
| Ilan, J | 1 |
| Holden, JT; Wilson, OH | 1 |
| Breitman, TR; Finkleman, A; Rabinovitz, M; Reagan, RL | 1 |
| Roberts, S | 1 |
| Egyházi, E | 1 |
| Generalov, OV | 1 |
| Cerná, J; Chládek, S; Pulkrábek, P; Rychlík, I; Zemlicka, J | 1 |
| Fraenkel-Conrat, H; Singer, B | 1 |
| Berg, CM; Rossi, JJ | 1 |
| Swanson, RF | 1 |
| Bremer, H; Brunschede, H | 1 |
| Dunlap, BE; Friderici, KH; Rottman, F | 1 |
| Arimura, A; Baba, Y; Matsuo, H; Nair, RM; Schally, AV | 1 |
| Hoare, DS; Hoare, SL; Taylor, BF | 1 |
| Breitman, TR; Finkleman, A; Rabinovitz, M | 1 |
| Kotyk, A; Ponec, M; Ríhová, L | 1 |
| Daughaday, WH | 1 |
| Glimcher, MJ; Huddleston, J; Levine, PT; Seyer, J | 1 |
| Campbell, JJ; Tomlinson, GA | 1 |
| Glenner, GG; Nagatsu, I; Nagatsu, T | 1 |
| Kinoshita, Y; Nemoto, G; Ujiie, A | 1 |
| Sashital, KS; Zimmerman, LN | 1 |
| Pierpoint, WS | 1 |
| Gronlund, AF; Kay, WW | 1 |
| Cahill, CF; Felig, P; Marliss, E; Ohman, JL | 1 |
| Inoue, H; Kasper, CB; Pitot, HC | 1 |
| Bowers, C; Chang, JK; Currie, B; Folkers, K; Sievertsson, H | 1 |
| Karle, IL | 1 |
| Camargo, AC; Greene, LJ; Ramalho-Pinto, FJ | 1 |
| Bengtsson, G | 1 |
| Peterson, NA; Raghupathy, E | 1 |
| Franchi, R; Gazzola, GC; Guidotti, GG; Ronchi, P; Saibene, V | 1 |
| McKean, CM; Peterson, NA; Raghupathy, E | 1 |
| Munck, BG | 2 |
| Christiansen, PA; Reiser, S | 2 |
| Rische, H; Tschäpe, H | 1 |
| Hahn, K; Jesdinsky, HJ; Ladner, HA | 1 |
| Boling, JA; Bradley, NW; Willard, JC | 1 |
| Nagatsu, I; Nagatsu, T; Oya, H | 1 |
| Fischer, HA; Schmatolla, E | 1 |
| Ahonen, J; Mäenpää, PH | 1 |
| Pan, MW; Riggs, TR | 1 |
| Clark, KG; Lehmann, H; Lorkin, PA; Wiltshire, BG | 1 |
| Morishita, S; Muramatsu, K; Odagiri, H; Takeuchi, H | 1 |
| Ono, T; Tasaki, I | 1 |
| Craft, IL; Peters, TJ | 1 |
| Campbell, DJ; Reid, DW; Yakymyshyn, LY | 1 |
| Birt, LM; Williams, KL | 1 |
| Dill, BC; Fuller, MS | 1 |
| Balasubramanian, R; Lakshminarayanan, AV; Ramachandran, GN; Sabesan, MN; Tegoni, G; Venkatesan, K | 1 |
| Hunter, DR; Segel, IH | 1 |
| Shearer, TR; Suttie, JW | 1 |
| Donlon, J; Fottrell, PF | 1 |
| Basmadjian, G; Floss, HG | 1 |
| Barooshian, AV; Harris, WG; Lautenschleger, MJ | 1 |
| Ermol'eva, ZV; Kolosova, IV; Pasternak, NA; Pokidova, NV; Shenderovich, VA | 1 |
| Alpers, DH; Bartoscas, CS; Bixby, EM; Shih, VE; Thier, SO | 1 |
| Genel, M; Rea, CF; Segal, S | 1 |
| Basmadjian, GP; Erge, D; Floss, HG; Gröger, D; Tcheng, M | 1 |
| Kabat, EA | 1 |
| Kotelchuck, D; Scheraga, HA | 1 |
| Glick, MC; Warren, L | 1 |
| Hellman, A; Hellman, KB; Martin, DH; Novelli, GD; Yang, WK | 1 |
| Gallo, RC; Pestka, S | 1 |
| Kawakatsu, K; Mori, M; Tamura, K | 1 |
| Celis, ME; Taleisnik, S; Walter, R | 1 |
| Geisler, C; Höcker, P; Stacher, A; Wiser, M | 1 |
| Kastin, AJ; Schally, AV; Viosca, S | 1 |
| Erwin, NS; Goldschmidt, EP; Matney, TS; Scroggs, RA | 1 |
| Jones, OW; Nirenberg, MW | 1 |
| Appella, E; Martin, RG; Voll, MJ | 1 |
| Sashikata, K; Tanaka, N; Umezawa, H; Yamaguchi, H | 1 |
| Tanaka, N; Yamaguchi, H; Yoshida, Y | 1 |
| Midgley, AR; Niswender, GD; Rasco, MA; Reichert, LE; Ward, DN | 1 |
| Betuel, H; Colobert, L; Richard, G | 1 |
| Melvås, BW | 1 |
| Gilles, R; Schoffeniels, E | 1 |
| Ermol'eva, ZV; Pokidova, NV; Zhuravleva, TP | 1 |
| Love, JN; Wiygul, G | 1 |
| Dolly, JO; Fottrell, PF | 1 |
| Fuchs, G; Oepen, H; Oepen, I | 1 |
| Mackenzie, S; Scriver, CR | 1 |
| Cooper, IA; Firkin, BG | 1 |
| Carbonell, AW; Franks, LM; Gey, GO; Riddle, PN | 1 |
| Lanks, KW | 1 |
| Adams, HR; Efremov, GD; Huisman, TH; Reynolds, CA; Wilson, JB; Wrightstone, RN | 1 |
| Levin, RJ | 1 |
| Nicholson, I | 1 |
| Ermol'eva, ZV; Evseenko, LK; Iulikova, EP; Kolosova, IV; Pasternak, NA; Pokidova, NV; Shenderovich, VA; Silaev, AB | 1 |
| Gold, J | 1 |
| Karlsson, BW; Lindberg, T | 1 |
| Khan, N; Lindblad, BS; Rahimtoola, RJ | 1 |
| Cohen, JS; Putter, I; Smith, JL; Vandenheuvel, WJ | 1 |
| Grimble, RF; Whitehead, RG | 1 |
| Goldstein, S; Reddy, WJ | 1 |
| Sodek, L; Wilson, CM | 1 |
| Lajtha, A; Sadasivudu, B | 1 |
| Grimley, PM; Vanha-Perttula, T | 1 |
| Neuhoff, V; Weise, M | 1 |
| Nobel, PS; Wang, CT | 1 |
| Moore, S; Salnikow, J; Stein, WH | 1 |
| Chou, WS; Ghadimi, H; Kesner, L | 1 |
| Budzynski, AZ | 1 |
| Berg, NO; Dahlqvist, A; Lindberg, T; Nordén, A | 1 |
| Gevers, W; Kleinkauf, H; Lipmann, F; Roskoski, R | 1 |
| Fürst, P; Josephson, B; Vinnars, E | 1 |
| Melcher, G | 1 |
| Tada, K; Takada, G | 1 |
| Baranova, IP; Egorov, NS | 1 |
| Hampton, JR | 1 |
| Albert, J; Collombel, C; David, M; Guerrier, G; Guibaud, P; Jeune, M; Michel, M | 1 |
| Bonk, U; Coutelle, C; Coutelle, R; Felicetti, D; Rath, FW; Traub, F | 1 |
| Charlesworth, D; Hollán, SR; Lehmann, H; Lorkin, PA; Miltényi, M; Szelényi, JG | 1 |
| Bayley, HS; Carlson, KH | 1 |
| Baker, RD; George, MJ | 1 |
| Orlov, VM; Shcherbukhin, VV; Spivak, VA; Varshavsky, JM | 1 |
| Balasubramanian, M; Myers, RF | 1 |
| Agranoff, BW; Elam, JS | 1 |
| Dintzis, HM; McMenamy, RH; Watson, F | 1 |
| Fitak, BA; Nahm, HS; Neill, JD; Reichart, LE; Sweeney, CM; Ward, DN | 1 |
| Flory, B; Krassner, SM | 1 |
| Bengtsson, SG | 1 |
| Field, M; Rubino, A; Shwachman, H | 1 |
| Figenschou, KJ; Froholm, LO; Laland, SG | 1 |
| Kickuth, R; Scheffer, F; Schlimme, E | 1 |
| Morikawa, T; Tada, K | 1 |
| Carrell, RW; Lehmann, H; Pribilla, W | 1 |
| Kelly, DP | 1 |
| Demeyer, DI; Henderickx, HK | 1 |
| Atassi, MZ; Taubman, MA | 1 |
| Thiry, L | 1 |
| Ellis, S; McDonald, JK; Reilly, TJ; Zeitman, BB | 1 |
| Mohyuddin, F; Scriver, CR | 1 |
| Pikkarainen, J | 1 |
| Brassil, D; Kern, HL | 2 |
| Brown, HH | 1 |
| Steenbergen, ST; Weinberg, ED | 1 |
| Berg, TL; Bredesen, JE; Figenschou, KJ; Froholm, LO; Laland, SG | 1 |
| Bonner, J; DeLange, RJ; Fambrough, DM; Smith, EL | 1 |
| Bairos, MA; Bairos, VA | 1 |
| Harman, RE; Patterson, JL; VandenHeuvel, WJ | 1 |
| Hosoya, M; Morita, Y; Tatsuno, T; Ueno, I; Ueno, Y | 1 |
| Howe, R; Moore, RH | 1 |
| Fukushima, K; Ueno, Y | 1 |
| Hogan, JP; Lindsay, JR; Weston, RH | 1 |
| Denamur, R; Gaye, P | 2 |
| Anderson, NG; Holleman, JW; Stevens, RH | 1 |
| Harris, BG; Read, CP | 1 |
| Hillman, R; Rose, R | 1 |
| Alperin, JB; Brimhall, B; Jones, RT; Schneider, RG; Ueda, S | 1 |
| Schoonhoven, LM | 1 |
| Carneiro, J; Saldanha, RV | 1 |
| Landau, RL; Lugibihl, K | 2 |
| Li, CH; Papkoff, H; Samy, TS | 1 |
| Bayfield, RF; Cole, ER | 1 |
| Jefferson, LS; Korner, A | 1 |
| Doolittle, RF; Uliana, JA | 1 |
| Arme, C; Read, CP | 1 |
| Tsuzuki, J | 1 |
| Honda, I; Kanaoka, M; Naruse, M; Sakakibara, S | 1 |
| Ptitsyn, OB | 1 |
| Menden, E; Vangala, RR | 1 |
| Gineitis, AA; Vinogradova, IA; Vorobyev, VI | 1 |
| Daniels, VG; Newey, H; Smyth, DH | 1 |
| Beljanski, M | 1 |
| Juva, K; Kulonen, E; Lampiaho, K | 1 |
| Halpern, B; Westley, JW | 2 |
| Datta, A; Sen, SP | 1 |
| Dennis, ES; Goodchild, CG | 1 |
| Berry, HK; Leonard, CS | 1 |
| Cooney, JJ; Thierry, OC | 1 |
| Gaffar, A; Sagers, RD; Terry, DR | 1 |
| Agrawal, HC; Davis, JM; Himwich, WA | 1 |
| Adamson, LF; Anast, CS; Langeluttig, SG | 1 |
| Huang, JM; Wang, IS; Wang, KT | 1 |
| Cocking, EC; Hall, TC | 1 |
| Fujita, T; Hoshino, O; Ikekawa, N; Orimo, H; Watanuki, R; Yoshikawa, M | 1 |
| Gurley, LR; Kischer, CW; Shepherd, GR | 1 |
| Gerok, W; Schimassek, H | 1 |
| Bakerman, S; Burgstahler, AW; Hayden, JW; Martin, RL | 1 |
| Carver, MJ; Ryan, WL | 1 |
| Moser, HW; Prensky, AL | 1 |
| Bourke, JB; Massey, LM; Stillings, BR | 1 |
| Braams, R | 1 |
| Adamson, LF; Ingbar, SH | 1 |
| Getoff, N; Schenck, GO | 1 |
| Antonioli, JA; Robinson, JW; Vannotti, A | 1 |
| Francis, FJ; Fuleki, T | 1 |
| Schweiger, RG | 1 |
| Estes, FL; Wetzel, RL | 1 |
| Scott, HM; Zimmerman, RA | 2 |
| Harper, E; Scharrer, B; Seifter, S | 1 |
| Masukawa, H; Tanaka, N; Umezawa, H | 1 |
| Oliver, IT; Yeung, D | 1 |
| Carrell, RW; Lehmann, H; Sansone, G | 1 |
| Komersová, I; Kybal, J; Majer, J | 1 |
| Eliasson, E | 1 |
| Arvill, A | 1 |
| Heath, JK; Meikle, MC; Reynolds, JJ | 1 |
| Contreras, PC; Takemori, AE | 1 |
| Chung, YC; Erickson, RH; Freeman, HJ; Kim, YS; Morita, A; Sleisenger, MH | 1 |
| Adinolfi, AM; Cospito, JA; Levine, MS | 1 |
| Dautrevaux, M; Demouveau, G; Nuyts, JP; Rousseaux, J | 1 |
| Calaresu, FR; Ciriello, J | 1 |
| Mizuno, N; Nakamura, Y; Nomura, S; Sugimoto, T | 1 |
| Mesulam, MM; Pandya, DN; Van Hoesen, GW | 1 |
| Herkenham, M; Pert, CB | 1 |
| Hosoya, Y; Matsushita, M | 1 |
| Itoh, K; Mizuno, N; Sugimoto, T | 1 |
| Horel, JA; Stelzner, DJ | 1 |
| Phelan, KD; Wilson, CJ | 1 |
| Asanuma, C; Jones, EG; Thach, WR | 1 |
| Asanuma, C; Jones, EG; Thach, WT | 1 |
| Miceli, D; Repérant, J; Rio, JP; Villalobos, J | 1 |
| Ash, GR; Cox, GB; Downie, JA; Fimmel, AL; Gibson, F; James, LB; Jans, DA; Langman, L; Senior, AE | 1 |
| Amaral, DG; Cowan, WM; Insausti, R | 1 |
| Carleton, SC; Carpenter, MB | 1 |
| Advis, JP; Krause, JE; McKelvy, JF; Reiner, AJ | 1 |
| Andrezik, JA; Dormer, KJ; Foreman, RD; Person, RJ | 1 |
| Chen, S; Lao, W; Ni, Z; Shi, L | 1 |
| Makino, K; Riesz, P | 1 |
| Beckstead, RM | 1 |
| Katakai, R; Kato, H; Nishimura, T; Okitani, A | 1 |
| Checler, F; Emson, PC; Kitabgi, P; Vincent, JP | 1 |
| Karasev, VS; Pankov, IuA | 1 |
| Feneant, M; Gautier, M; Guerroui, S; Lemonnier, A; Maccario, J; Moatti, N | 1 |
| Bańkowski, E; Pawlicka, E | 1 |
| Derr, JT; Smith, GL | 1 |
| Hui, KS; Lajtha, A | 1 |
| Barker, HA | 1 |
| Ciliberto, G; Cortese, R; Traboni, C | 1 |
| Becker, JM; Merkel, GJ; Naider, F | 1 |
| Ayukawa, S; Fisher, JM; Rabinovitz, M | 1 |
| Hori, K; Kanda, M; Kurotsu, T; Miura, S; Saito, Y; Yamada, Y | 1 |
| Mayer, RJ; Razooki Hasan, H; White, DA | 1 |
| Marshall, CA; Murphy, MG; Tolbert, DL | 1 |
| Bünting, C; Gries, FA; Koschinsky, T; Schwippert, B | 1 |
| Boyd, CA; Perring, VS | 1 |
| Hayashi, K; Kawasaki, T | 1 |
| Anguat, P; Cicirata, F | 1 |
| Ananthanarayanan, VS; Shyamasundar, N | 1 |
| Stark, AA; Yankofsky, SA | 1 |
| Berkley, KJ; Molinari, HH | 1 |
| Aoyagi, H; Izumiya, N; Kato, T; Yasutake, A | 1 |
| Adam, M; Brettschneider, I; Deyl, Z; Krabcova, M; Musilova, J; Pesakova, V | 1 |
| Hoshino, T; Matsuoka, M; Miwa, S; Miyaji, T; Nakayama, S; Ohba, Y; Ueno, K; Yamamoto, K | 1 |
| Mulligan, K; Sherk, H | 1 |
| Evans, DB; Fan, N; Rank, KB; Sharma, SK; Tarpley, WG; Thomas, RC | 1 |
| Colón, W; Kelly, JW; Lai, Z; McCutchen, SL; Miroy, GJ | 1 |
| Ahrendt, GM; Barbul, A; Gardiner, KR; Gardiner, RE | 1 |
| Carroll, RJ; Chan, SJ; Guz, Y; Hammer, RE; Steiner, DF; Teitelman, G; Vincent, MT | 1 |
| Fujieda, K; Morioka, H; Nakae, J; Ohtsuka, E | 1 |
| Beolet, M; Cartron, JP; Colin, Y; Le Van Kim, C; Rouillac, C | 1 |
| Aloyz, RS; DesGroseillers, L | 1 |
| Albanese, C; Du, GG; Gu, WX; Jameson, JL; Kohn, LD; Kopp, P; Madison, LD; Rentoumis, A | 1 |
| Park, WY; Seo, JS | 1 |
| Blight, MA; Dando, C; Holland, IB; Kotelevets, L; Lazzaroni, JC; Pimenta, AL; Séror, SJ | 1 |
| Deshaies, Y; Julien, P; Lévesque, G; Lupien, PJ; Ven Murthy, MR | 1 |
| Collins, TS; Julian, B; McLean, RH; Niblack, G; Phillips, JA; Valle, D; Wang, T; Winkelstein, J; Wyatt, R | 1 |
| Chauvel, B; Dorval, I; Dubourg, C; Jezequel, P; Le Gall, JY; Le Pogamp, P | 1 |
| Alexander, RS; Christianson, DW; Jain, A; Whitesides, GM | 1 |
| Chapman, TE; Cortiella, J; Hiramatsu, T; Marchini, JS; Young, VR | 1 |
| Browning, JE; Repaske, DR | 1 |
| Kuwabara, T; Suzuki, K | 1 |
| Levine, MJ; Paranchych, W; Reddy, MS | 1 |
| de Castro, CM; Devlin, B; Fleenor, DE; Kaufman, RE; Lee, ME | 1 |
| Arlt, G; Brooks, DA; Hopwood, JJ; Isbrandt, D; Peters, C; von Figura, K | 1 |
| Ali, M; Cox, TM; Sebastio, G | 1 |
| Fernandez, LM; Grumbles, RM; Hall, CR; Jin, S; Oates, EL; Puett, D; Stein, SA; Taylor, NA | 1 |
| Barbul, A; Gardiner, KR; Gardiner, RE | 1 |
| Teeter, MM; Yamano, A | 1 |
| Livne, E; Weiss, A | 1 |
| Colon, W; Kelly, JW; McCutchen, SL | 1 |
| Berk, JL; Fine, A; Goldstein, RH; Krupsky, M | 1 |
| Benezra, R; Pesce, S | 1 |
| Ballermann, BJ; Choi, ME; Huang, Q; Kim, EG | 1 |
| Boulay, F; Mery, L | 1 |
| Bruce, LJ; Kay, MM; Lawrence, C; Tanner, MJ | 1 |
| Duronio, RJ; Gordon, JI; Johnson, DR; Langner, CA; Rudnick, DA | 1 |
| Nagai, T; Shirabe, K; Takeshita, M; Yubisui, T | 1 |
| Alloisio, N; Dalla Venezia, N; Delaunay, J; Dhermy, D; Forissier, A; Garbarz, M; Morlé, L; Parquet, N; Rousset, T; Wilmotte, R | 1 |
| Essenberg, RC; Sharma, YK | 1 |
| Gour-Salin, BJ; Lachance, P; Ménard, R; Plouffe, C; Storer, AC | 1 |
| Chang, MF; Chang, SC; Chen, CJ; Sun, CY | 1 |
| Budde, U; Dent, JA; Holmberg, L; Ruggeri, ZM; Schneppenheim, R; Ware, J | 1 |
| Chen, SS; Lee, CN; Lee, TH; Lee, WR; McIntosh, K | 1 |
| Buchwald, M; dos Santos, CC; Gavish, H | 1 |
| Ballerini, G; Bernardi, F; Furbetta, M; Gemmati, D; Lunghi, B; Marchetti, G; Moratelli, S; Serino, ML | 1 |
| Anderson, VE; Goshe, MB | 1 |
| Chung, BC; Hsu, LC; Hsu, NC; Hu, MC | 1 |
| Al-Maghtheh, M; Bhattacharya, S; Inglehearn, C; Keen, J; Tarttelin, E | 1 |
| Iguchi, T; Iwashita, M; Kudo, Y; Takeda, Y | 1 |
| Hoshino, S; Kobayashi, Y; Onoda, A | 1 |
| Gonzalez, E; Vinardell, MP | 1 |
| Armstrong, DW; Ekborg-Ott, KH | 1 |
| Arnoys, EJ; Blankespoor, S; Born, T; Everman, R; Gray, TM; Jagar, R; Plowman, D; Stair, A; Zhang, D | 1 |
| Danpure, CJ; Leiper, JM; Oatey, PB | 1 |
| Guillemette, JG; Parrish, JC; Smith, M; Wallace, CJ; Woods, AC | 1 |
| Aisaka, K; Hirano, A; Shinkai, A | 1 |
| Barnett, CR; Flatt, PR; McClenaghan, NH; O'Harte, FP | 1 |
| Hisa, T; Kakudo, K; Kaname, A; Nakamura, M; Sasaki, M; Shan, L; Tsukino, R; Yokoi, T; Zhang, ZQ | 1 |
| Gallard, JF; Guittet, E; Le, HT; Mayer, M; Michelot, R | 1 |
| Choquet, Y; Kössel, H; Kuras, R; Wollman, FA; Zito, F | 1 |
| Asking, B; Proctor, GB; Shori, DK; Suares, JC | 1 |
| Andersen, HA; Didion, T; Grauslund, M; Kielland-Brandt, MC | 1 |
| Lachowicz, TM; Obłak, E; Witek, S | 1 |
| Gorski, J; Maslanka, K; Wu, S | 1 |
| Dean, RT; Fu, SL | 1 |
| Chianelli, MS; Mattoon, JR; Ramos, EH; Sáenz, DA; Stella, CA | 1 |
| Bergès, T; Guyonnet, D; Karst, F | 1 |
| Caprio, J; Valentincic, T | 1 |
| Arango, V; Uhing, MR | 1 |
| Corsi, D; Guetard, D; Kramer, L; Magnani, M; Montagnier, L; Montroni, M; Picerno, I; Piedimonte, G; Silvestri, G; Spataro, P; Torres Roca, JF | 1 |
| Arauz-Ruiz, P; Magnius, LO; Norder, H; Visoná, KA | 1 |
| Aldape, RA; Cameron, AM; Fung, ET; Livingston, DJ; Nucifora, FC; Ross, CA; Snyder, SH | 1 |
| Anwar, R; Markham, AF; Puntis, JW | 1 |
| Brüssow, H; Hotop, H; Rohwedder, A | 1 |
| Cai, X; Johnstone, RM; Lin, G | 1 |
| Kanazawa, H; Moritani-Otsuka, C; Sawada, K; Watanabe, H | 1 |
| Kowarz, L; Norel, F; Robbe-Saule, V; Schaeffer, F | 1 |
| Barone, G; Cafaro, V; Catanzano, F; D'Alessio, G; Di Donato, A; Graziano, G | 1 |
| Dahlbäck, B; Fernlund, P; García de Frutos, P; Linse, S; Lövenklev, M; Villoutreix, BO | 1 |
| Flegel, WA; Hillesheim, B; Wagner, FF | 1 |
| Briones, P; Climent, C; García-Pérez, MA; Rodés, M; Rubio, V; Vilaseca, MA | 1 |
| Dickson, RC; Lester, RL; Nagiec, MM; Skrzypek, MS | 1 |
| Ariyoshi, Y; Ota, M; Shimizu, Y; Tonosaki, K | 1 |
| Chen, F; Coller, BS; French, DL; Grimaldi, CM; Weiss, HJ; Wu, C | 1 |
| Andria, G; Farina, V; Filocamo, M; Grillo, G; Guidi, G; Parenti, G; Rizzolo, MG; Rotondo, A; Santamaria, F; Sarnelli, P; Strisciuglio, P | 1 |
| Akcakaya, N; Apak, M; Camcioglu, Y; Cokugras, H; Gokgoz, N; Kayserili, H; Kirdar, B; Onay, T; Topaloglu, O; Tsui, LC; Zielenski, J | 1 |
| Ramadevi, N; Rodriguez, J; Roy, P | 1 |
| Abe, M; Araki, R; Eguchi-Kasai, K; Fujimori, A; Fukumura, R; Itsukaichi, H; Mori, M; Saito, T; Sarashi, M; Sato, K; Tatsumi, K; Watanabe, F | 1 |
| Hull, D; Lappin, TR; Mayne, EE; McHale, CM; Winter, PC | 1 |
| Hope, J; Manson, JC; Melton, DW; Moore, RC; Redhead, NJ; Selfridge, J | 1 |
| Hincha, DK; Popova, AV; Schmitt, JM | 1 |
| Barnes, DM; Camplejohn, RS; Hupp, TR; Lomax, ME; Picksley, SM | 1 |
| Arrowsmith, CH; Davison, TS; Kay, C; Nie, E; Yin, P | 1 |
| Damas, AM; Saraiva, MJ; Sebastião, MP | 1 |
| Badmajew, E; Dowjat, WK; Kuchna, I; Kulczycki, J; Popovitch, E; Tarnawski, M; Wegiel, J; Wisniewski, HM; Wisniewski, T | 1 |
| Cleek, GJ; Graber, DR; Keiser, BJ; Kopta, LA; Morris, J; Murphy, MJ; Nugent, RA; Olmsted, RA; Poel, TJ; Poppe, SM; Schlachter, ST; Swaney, SM; Tarpley, WG; Thomas, RC; Wishka, DG; Yagi, Y | 1 |
| Goto, J; Harada, A; Hase, M; Ikeda, K; Kanematsu, M; Miyauchi, A; Okuizumi, H; Takagi, Y; Takai, H; Yamada, Y | 1 |
| Bonkobara, M; Inaba, M; Matsuki, N; Ono, K; Thongsong, B | 1 |
| Chang, JG; Jong, YJ; Lee, CC; Lin, SP; Lo, MC; Tsai, CH; Tsai, FJ; Wu, JY; Yang, CF | 1 |
| Cantu, JM; Hernandez-Romo, JA; Leal, CA; Lin, C; Ramirez-Casillas, GA; Ramirez-Dueñas, MG; Rogaeva, EA; St George-Hyslop, PH | 1 |
| Appleby, R; De Stefano, V; Fitches, AC; Lane, DA; Leone, G; Olds, RJ | 1 |
| Dekker, JM; Hart, LM; Karvonen, MK; Koulu, M; Laakso, M; Niskanen, L; Pesonen, U; Rissanen, A; Uusitupa, MI; Valve, R | 1 |
| Kelly, JW; Lai, Z; Lashuel, HA | 1 |
| Dubey, RK; Gillespie, DG; Jackson, EK | 1 |
| Booth, DR; Booth, SE; Brett, M; Hawkins, PN; Morgan-Hughes, JA; Pepys, MB; Persey, MR; Reilly, MM; Revesz, T | 1 |
| Barrow, CJ; Beyreuther, K; Cappai, R; Collins, SJ; Jobling, MF; Masters, CL; Stewart, L; Thyer, JM; White, AR | 1 |
| Rothen, SA; Sauer, M; Sonnleitner, B; Witholt, B | 1 |
| Morris, R; Pandya, DN; Petrides, M | 1 |
| Aston, CE; DeKosky, ST; Ferrell, RE; Hardy, J; Kamboh, MI; Kokmen, E; Perez-Tur, J | 1 |
| Cetani, F; Cianferotti, L; Marcocci, C; Miccoli, P; Pardi, E; Picone, A; Pinchera, A; Vignali, E | 1 |
| Anagnostopoulos, I; Fechner, H; Haack, A; Merklein, F; Poller, W; Schneider-Rasp, S; Wang, H; Weidinger, S | 1 |
| Chamson, A; Doumit, J; Frey, J; Le, J; Perier, C | 1 |
| Hibino, R; Kawano, Y; Kumagai, T; Sugiyama, M | 1 |
| Bertini, E; Cappa, M; Gomez-Lira, M; Mottes, M; Perusi, C; Pignatti, PF; Rizzuto, N; Salviati, A; Schiffer, D; Vigliani, MC | 1 |
| Green, FR; Watkins, H | 1 |
| Inaba, A; Itoh, Y; Kamata, T; Kayano, T; Kitamoto, T; Matsushita, M; Mizusawa, H; Okeda, R; Otomo, E; Satoh, S; Suematsu, N; Takashima, M; Wada, Y; Yamada, M | 1 |
| Inoue, T; Jackson, EK | 1 |
| Endo, S; Fujiki, K; Hotta, Y; Ishida, N; Kanai, A; Nakayasu, K; Nguyen, TH; Yamaguchi, T | 1 |
| Akimenko, MA; Haché, RJ; Lemieux, ME; Pope, L; Préfontaine, GG; Wang, JM | 1 |
| DenBesten, PK; Gao, C; Li, W; Machule, D | 1 |
| Kelly, JW; Lashuel, HA; Woo, L; Wurth, C | 1 |
| Brandrup, F; Hamburger, J; Lane, E; Magee, G; Rugg, E; Wilson, N | 1 |
| Bourbon, M; Fowler, AM; Soutar, AK; Sun, XM | 1 |
| Arora, KK; Catt, KJ; Chung, HO; Yang, Q | 1 |
| Avitabile, E; Campadelli-Fiume, G; Cocchi, F; Dubreuil, P; Lopez, M; Menotti, L | 1 |
| Billiemaz, K; Damon, G; Ibrahim, A; Rayet, I; Tardy, B; Teyssier, G | 1 |
| Karvonen, MK; Koulu, M; Pesonen, U; Rönnemaa, T; Simell, O; Tammi, A; Uusitupa, MI; Viikari, J | 1 |
| Helisalmi, S; Hiltunen, M; Karvonen, MK; Koulu, M; Mannermaa, A; Pesonen, U; Pirskanen, M; Soininen, H; Uusitupa, M; Valve, R | 1 |
| Karvonen, MK; Koulu, M; Laakso, M; Mercuri, M; Niskanen, L; Pesonen, U; Rauramaa, R; Töyry, J; Uusitupa, MI; Valve, R | 1 |
| Karvonen, MK; Kauhanen, J; Koulu, M; Pesonen, U; Salonen, JT; Tuomainen, TP; Uusitupa, MI | 1 |
| Chan, BY; Chan, KY; Chan, YT; Chan, YW; Lam, CW; Tong, SF | 1 |
| Kestin, AS; Newman, PJ; Ward, CM | 1 |
| Castilla-Cortazar, I; Garcia, M; Pascual, M; Picardi, A; Prieto, J; Quiroga, J; Urdaneta, E | 1 |
| Karvonen, MK; Koulu, M; Laakso, M; Niskanen, L; Pesonen, U; Teräsvirta, M; Uusitupa, MI; Valve, R; Voutilainen-Kaunisto, R | 1 |
| Yamada, Y | 1 |
| Damas, AM; Merlini, G; Saraiva, MJ; Sebastião, MP | 1 |
| Baan, CC; Balk, AH; Holweg, CT; Maat, LP; Niesters, HG; van Riemsdijk, IC; Vantrimpont, PJ; Weimar, W | 1 |
| Erdmann, J; Fleck, E; Hahner, A; Kallisch, H; Regitz-Zagrosek, V | 1 |
| Chabás, A; Coll, MJ; Gort, L | 1 |
| Aegerter, P; Boileau, C; Devillers, M; Junien, C; Krempf, M; Rabès, JP; Varret, M; Villéger, L | 1 |
| Atreya, CD; Mohan, KV | 1 |
| Buddington, RK; Elnif, J; Malo, C; Sangild, PT | 1 |
| Blandl, T; Castellino, FJ; Prorok, M; Zajicek, J | 1 |
| De Siervi, A; del C Batlle, AM; Parera, VE; Rossetti, MV | 1 |
| Andersson, PM; de Faire, U; Forsberg, L; Marklund, SL; Morgenstern, R; Stegmayr, B | 1 |
| Buddington, RK; Elnif, J; Puchal-Gardiner, AA; Sangild, PT | 1 |
| Bhattacharya, SS; Deery, EC; Hunt, DM; Newbold, RJ; Srinivasan, N; Walker, CE; Warren, MJ; Wilkie, SE | 1 |
| Birch, DG; Bowne, SJ; Daiger, SP; Heckenlively, JR; Lewis, RA; Mintz-Hittner, H; Northrup, H; Rodriquez, JA; Ruiz, RS; Saperstein, DA; Sohocki, MM; Sullivan, LS | 1 |
| Azmani, A; Cavelier, F; Haddadi, ME; Martinez, J; Verducci, J; Vives, E | 1 |
| Bjørkhaug, L; Horikawa, Y; Molven, A; Njølstad, PR; Søvik, O; Ye, H | 1 |
| Beaumier, L; Castillo, L; Lu, XM; Ryan, CM; Tompkins, RG; Young, VR; Yu, YM | 1 |
| Mingarro, I; Nilsson, I; von Heijne, G; Whitley, P | 1 |
| de Eguileor, M; Fiandra, L; Giordana, B; Grimaldi, A; Lanzavecchia, G; Leonardi, MG; Tettamanti, G; Valvassori, R | 1 |
| Baker, DW; Bradley, JF; Huelsman, KM; Rothberg, PG | 1 |
| Barboza, M; Fainboim, L; Kado, M; Rosselot, C; Salamone, GV; Salamone, MC | 1 |
| Enders, D; Kirchhoff, JH; Köbberling, J; Peiffer, TH | 1 |
| Ando, T; Drube, J; Inada, T; Kawamura, N; Komaki, G; Nakamura, A | 1 |
| Hirakawa, Y; Ikeda, A; Kataoka, Y; Makino, K; Oishi, AR; Yamauchi, A | 1 |
| Dyer, PA; Haworth, SE; Hull, PS; Irwin, CR; James, JA; Linden, GJ; Marley, JJ; Maxwell, AP; McNamee, P; Middleton, D; Poulton, KV; Short, CD | 1 |
| Dangel, BD; Johnson, JA; Sames, D | 1 |
| Basiuk, VA; Douda, J | 1 |
| Karvonen, MK; Kauhanen, J; Koulu, M; Lakka, HM; Lakka, TA; Nyyssönen, K; Pesonen, U; Salonen, JT; Salonen, R; Tuomainen, TP; Uusitupa, MI; Valkonen, VP | 1 |
| Anders, MW; Blackburn, AC; Board, PG; Coggan, M; Lantum, H; Parker, MW; Polekhina, G; Tzeng, HF | 1 |
| Hamase, K; Inoue, T; Konno, R; Morikawa, A; Zaitsu, K | 1 |
| Battaglia, FC; Di Noio, M; Fennessey, PV; Marconi, AM; Paolini, CL; Pardi, G; Ronzoni, S | 1 |
| Cadieux, N; Cafiso, DS; Coggshall, KA; Kadner, RJ; Piedmont, C | 1 |
| Batenburg, JJ; Haagsman, HP; ten Brinke, A; Vaandrager, AB; van Golde, LM | 1 |
| Afsari, A; Garlie, J; Gorski, J; Yassai, M | 1 |
| Balasubramaniam, A; F Qureshy, A; Kasckow, JW; Sheriff, S; T Chance, W | 1 |
| Brice, A; Campion, D; Durr, A; Frebourg, T; Hahn, V; Jacquemont, ML; Tallaksen, C | 1 |
| Agren, JJ; Hallikainen, MA; Jauhiainen, M; Karvonen, MK; Koulu, M; Pesonen, U; Sarkkinen, ES; Savolainen, MJ; Schwab, US; Uusitupa, MI; Valve, R | 1 |
| Combrié, R; Gauthier, B; Kunicki, T; Nurden, AT; Nurden, P; Pasquet, JM; Ruan, J | 1 |
| Erkkilä, AT; Laakso, M; Lehto, S; Lindi, V; Uusitupa, MI | 1 |
| Boson, WL; Costa, JE; Cury, VF; De, ML; Gomez, RS; Loures, CG | 1 |
| Fréchet, JM; Ling, FH; Lu, V; Svec, F | 1 |
| Aebi, U; Cardoso, I; Damas, AM; Goldsbury, CS; Müller, SA; Olivieri, V; Saraiva, MJ; Wirtz, S | 1 |
| Fernandes, K; Michael-Titus, AT; Setty, H; Whelpton, R | 1 |
| Freeman, TL; Kharbanda, KK; Mailliard, ME; Tuma, DJ | 1 |
| Peng, ZY; Zhang, B | 1 |
| Adams, C; Babraj, J; Bohé, J; Cuthbertson, DJ; Gibson, JN; Meier-Augenstein, W; Rennie, MJ; Rickhuss, P; Smith, K; Wolfe, RR | 1 |
| Bertilsson, L; Ding, B; Wahlestedt, C | 1 |
| Bruno, C; Capanni, C; Carbone, I; Lisanti, MP; Merlini, L; Minetti, C; Sabatelli, P; Sotgia, F; Tortorelli, S | 1 |
| Csornai, M; Nagy, Z; Pongrácz, E; Tordai, A | 1 |
| Bettler, B; Blahos, J; Duthey, B; Havlickova, M; Pin, JP; Prezeau, L | 1 |
| Beeson, D; Brydson, M; Chauplannaz, G; Colquhoun, D; Croxen, R; Hatton, C; Newsom-Davis, J; Oosterhuis, H; Shelley, C; Vincent, A | 1 |
| Karlsson, JO | 1 |
| Findlay, JB; Nevett, CL; Wrigley, JD | 1 |
| Bonkobara, M; Inaba, M; Matsuki, N; Ohmori, T; Ono, K; Thongsong, B | 1 |
| Günther, U; Mittag, T; Schaffhausen, B | 1 |
| Moradian-Oldak, J; Wang, L | 1 |
| Friedrich, M; Lorenz, B; Preising, MN; Schindler, S; Wagener, H | 1 |
| Adriouch, S; Dox, C; Haag, F; Koch-Nolte, F; Seman, M; Welge, V | 1 |
| Jeoung, M; Ji, I; Ji, TH; Ryu, K; Sievert, G; Sohn, J | 1 |
| Eismann, U; Gerth, J; Sommer, M; Stein, G | 1 |
| Fernandes, R; Palha, JA; Saraiva, MJ; Sousa, MM; Taboada, A; Vieira, P | 1 |
| Bohác, M; Damborský, J; Koca, J; Monincová, M; Nagata, Y; Prokop, M; Prokop, Z; Tsuda, M | 1 |
| Brennan, SO; Johnson, S; Sheen, C | 1 |
| Hirano, T; Imai, H; Kuwayama, S; Shichida, Y; Terakita, A | 1 |
| Bullerjahn, GS; Crowley, PB; Ubbink, M; Vintonenko, N | 1 |
| Ariani, F; Borghgraef, M; Frints, SG; Froyen, G; Fryns, JP; Longo, I; Marynen, P; Meloni, I; Pescucci, C; Raynaud, M; Renieri, A; Schwartz, C | 1 |
| Mizusawa, H; Shiraishi, A; Yamada, M | 1 |
| Dhitavat, J; Dode, L; Hovnanian, A; Leslie, N; Macfarlane, S; MacSween, R; Saihan, E; Sakuntabhai, A | 1 |
| Bönisch, H; Brüss, M; Göthert, M; Kiel, S | 1 |
| Bruno, C; DeFlorio, L; Federico, A; Grieco, GS; Malandrini, A; Mancuso, M; Martini, B; Murri, L; Nappi, G; Petrini, S; Santorelli, FM; Siciliano, G; Tessa, A | 1 |
| Altroff, H; Mardon, HJ; van der Walle, CF | 1 |
| Browner, W; Cauley, J; Kahn, A; Morin, P; Saiz, R; Ziv, E | 1 |
| Corella, D; González, JI; Portolés, O; Ramírez, JB; Ruiz de la Fuente, S; Sorlí, JV | 1 |
| Boileau, G; Campos, M; Carmona, AK; Couture, C; Crine, P; Hirata, IY; Juliano, L; Juliano, MA; Loisel, TP | 1 |
| Doh-ura, K; Furuta, A; Iwaki, T; Morisada, Y; Nakashima, S; Sasaki, K; Tateishi, J | 1 |
| Kutscher, G; Lutze, G; Meyer, M; Riesener, G; Stürzebecher, J | 1 |
| Cardoso, I; Merlini, G; Saraiva, MJ | 1 |
| Chang-Claude, J; Dunning, AM; Easton, DF; Ellis, PD; Healey, CS; Kataja, V; Kemp, PR; Kirschenlohr, HL; Luben, RN; Mannermaa, A; McBride, S; Metcalfe, JC; Pharoah, PD; Ponder, BA | 1 |
| Huo, S; Lei, M; Yang, M | 1 |
| Ambrose, C; Benjamin, C; Bixler, SA; Cachero, T; Day, E; Gilbride, K; Gong, D; Gorelik, L; Hsu, YM; Kalled, SL; Pelletier, M; Qian, F; Thompson, JS; Whitty, A; Zafari, M | 1 |
| Diamond, AM; Hu, YJ | 1 |
| Hammar, N; Jartti, L; Järvisalo, MJ; Kaprio, J; Karvonen, MK; Koulu, M; Marniemi, J; Paakkunainen, U; Pesonen, U; Raitakari, OT; Rönnemaa, T; Simell, O | 1 |
| Aoki, M; Fukao, T; Inoue, R; Kaneko, H; Kasahara, K; Kato, Z; Kondo, N; Matsui, E; Suzuki, K; Suzuki, Y; Teramoto, T; Watanabe, M | 1 |
| Horie, C; Mihara, K; Sakaguchi, M; Suzuki, H | 1 |
| Bojesen, SE; Nordestgaard, BG; Tybjaerg-Hansen, A | 1 |
| Kastrati, A; Koch, W; Pesonen, U; Schömig, A | 1 |
| KAHN, JR; MARSH, WH; SHUMWAY, NP; SKEGGS, LT | 1 |
| MORGAN, JF; MORTON, HJ | 1 |
| KENNER, GW; SHEPPARD, RC | 1 |
| BENTLEY, OG; DEHORITY, BA; JOHNSON, RR; MOXON, AL | 1 |
| BOLLE, A; KELLENBERGER, E; LARK, KG | 1 |
| NYC, JF; SOBOREN, J | 1 |
| MAKISUMI, S; NICHOLLS, CH; SAROFF, HA | 1 |
| ADELBERG, EA; PITTARD, J | 1 |
| HAMMAR, H; HELLMAN, B; LARSSON, S | 1 |
| TANG, J | 1 |
| IKEKAWA, N | 1 |
| BANERJEE, AB; BOSE, SK | 1 |
| BAUER, JM; WU, C | 1 |
| SCHAECHTER, M | 1 |
| DUSHMAN, MB | 1 |
| RUMLEY, MK; UZMAN, LL; VANDENNOORT, S | 1 |
| SCHEPARTZ, B | 1 |
| BRAUN, L | 1 |
| HENRY, JC | 1 |
| JUVA, K; KULONEN, E | 1 |
| BAILY, P; HARINGTON, JS; KILROE-SMITH, TA | 1 |
| Anderson, JO; Dobson, DC; Warnick, RE | 1 |
| FRIED, VA; HASELKORN, R | 1 |
| NEAME, KD | 1 |
| HYATT, MT; LEVINSON, HS | 3 |
| LORINCZ, AB; RYAN, WL | 1 |
| CASSIDY, JE; LOWERY, JA | 1 |
| GRUNBERG-MANAGO, M; MICHELSON, AM | 1 |
| FOX, SW; YUYAMA, S | 1 |
| DELALLOSA, P; JUTISZ, M; TERTRIN, C | 1 |
| NEWEY, H; SMYTH, DH | 1 |
| POMEROY, LR; ROACH, MK; SIEGEL, FL | 1 |
| LIENER, IE; LOVELADY, HG; WAIBEL, PE | 1 |
| GERIFFIN, G; KESNER, L; MUNTWYLER, E | 1 |
| FAWAZ-ESTRUP, F; SETLOW, RB | 1 |
| KING, NK; LOONEY, FD; WINFIELD, ME | 1 |
| BOCKRATH, RC; PERSON, S | 1 |
| CRAIG, LC; KING, TP; RUTTENBERG, MA | 1 |
| SOFFER, RL | 1 |
| GOLDSTEIN, J; SCHLEICH, T | 1 |
| DEMEREC, M | 1 |
| HUNT, DE | 1 |
| GELBOIN, HV; SOKOLOFF, L | 1 |
| CHAMBERS, DA; SALZMAN, EW | 1 |
| BERNFIELD, MR; NIRENBERG, MW | 1 |
| BOYER, H | 1 |
| BEN-GURION, R; KINDLER, SH | 1 |
| NARITA, K; OGATA, K; SATO, N | 1 |
| CHARLES, R; FISCHER, G; GIL-AV, E | 1 |
| JOHNSON, AH; STOKES, JL | 1 |
| BLAU, K; DARBRE, A | 1 |
| Lede, MN; Rio, ME; Sanahuja, JC | 1 |
| HSU, TC; UTAKOJI, T | 1 |
| GROBSTEIN, C; KALLMAN, F | 1 |
| GORDON, DF; SPECK, ML | 1 |
| CLAMP, JR; HOUGH, L | 1 |
| BERG, TL; FROHOLM, LO; LALAND, SG | 1 |
| GADO, I; HORVATH, I | 1 |
| Huang, Z; Sui, Y; Weng, J; Xiu, L; Yan, J | 1 |
| Ahn, JY; Huang, H; Kalman, D; Kapp, JA; Nagata, E; Rong, R; Snyder, SH; Tu, J; Worley, PF; Ye, K | 1 |
| Ho, L; Ksiezak-Reding, H; Pasinetti, GM; Pompl, P; Pyo, H; Qin, W; Suh, J; Zhao, Z | 1 |
| Andreotti, G; Motta, A | 1 |
| Filosto, M; Leone, M; Mancuso, M; Murri, L; Nichelli, P; Siciliano, G; Tognoni, G | 1 |
| Lakatos, P; Patócs, A; Rácz, K; Salamon, D; Speer, G; Tóth, M; Tulassay, Z | 1 |
| Cruz, JC; Goldman, JA; Shih, H; Tsai, LH; Tseng, HC | 1 |
| Agostini, M; Chatterjee, VK; Garnes, KT; Gurnell, M; Levinson, SH; O'Rahilly, S; Rajanayagam, O; Savage, DB; Schwabe, JW; Smith, AG; Willson, TM; Wood, EM; Xu, HE | 1 |
| Gamero, AM; Larner, AC; Montenegro, J; Sakamoto, S | 1 |
| Fagerudd, JA; Forsblom, CM; Groop, PH; Kallio, J; Karvonen, MK; Koulu, M; Pesonen, U; Pettersson-Fernholm, K | 1 |
| Försti, A; Grzybowska, E; Hemminki, K; Jin, Q; Klaes, R; Söderberg, M | 1 |
| Auger, R; Kanellopoulos, J; Le Stunff, H; Raymond, MN | 1 |
| Coriu, D; Dispenzieri, A; Murphy, CL; Solomon, A; Stevens, FJ; Wang, S; Weiss, DT | 1 |
| Epe, M; Fehmann, HC; Gross, U | 1 |
| Hahm, KS; Lee, DG; Shin, SY | 1 |
| Huang, LE; Kageyama, Y; Koshiji, M; Ratcliffe, PJ; Tian, YM; To, KK | 1 |
| Baldazzi, L; Balsamo, A; Barbaro, M; Cacciari, E; Cicognani, A; Lajic, S; Pirazzoli, P; Wedell, A | 1 |
| Arbustini, E; Bellotti, V; Bergonzi, C; Calabresi, L; Donadei, S; Giorgetti, S; Gregorini, G; Marciano, S; Merlini, G; Obici, L; Palladini, G; Perfetti, V; Scolari, F; Verga, L | 1 |
| Cho, JM; Heo, YS; Hwang, KY; Hyun, YL; Jeon, YH; Kim, JH; Kim, SK; Kim, YK; Lee, HS; Lee, JI; Lee, TG; Park, SY; Ro, S; Seo, CI; Sung, BJ; Yang, CH | 1 |
| Barann, M; Bönisch, H; Brüss, M; Combrink, S; Göthert, M; Kostanian, A; Kurzwelly, D | 1 |
| Hahm, KS; Shin, SY | 1 |
| Attwood, PV; Barr, RK; Boehm, I; Bogoyevitch, MA; Watt, PM | 1 |
| Habuchi, T; Ichimura, Y; Kato, T; Nishiyama, H; Ogawa, O; Oyama, C; Sato, K; Tsuchiya, N; Wang, L | 1 |
| Harrison, NL; Schofield, CM; Trudell, JR | 1 |
| Sinclair, AJ; Webb, HM; West, MJ; Woolfson, DN | 1 |
| Kwak, EJ; Lim, SI | 1 |
| Heikkinen, AM; Jurvelin, J; Komulainen, MH; Koulu, M; Kröger, H; Niskanen, LK; Pesonen, U; Saarikoski, S; Salmi, JA; Tuppurainen, MT; Uusitupa, MI | 1 |
| Asbun, J; Manso, AM; Villarreal, FJ | 1 |
| Chaudhary, LC; McKain, N; Miyagawa, E; Walker, ND; Wallace, RJ | 1 |
| Baban, BA; Becker, DF; Schuermann, JP; Tanner, JJ; White, TA; Zhang, M | 1 |
| Garbern, J; Hobson, GM; Lee, ES; Moon, HK; Park, YH | 1 |
| Bisoendial, RJ; Brownlie, A; de Groot, E; Dube, MP; Dullaart, RP; Hayden, MR; Hovingh, GK; Kastelein, JJ; Kuivenhoven, JA; Levels, JH; Petersen, W; Stroes, ES; Zwinderman, AH | 1 |
| Adachi, M; Hayasaka, K; Kato, M; Sawaishi, Y; Shiihara, T | 1 |
| Clarke, NF; Dye, DE; Hagiwara, T; Kobayashi, Y; Laing, NG; Liyanage, K; Nishino, I; Nonaka, I; North, KN; Ouvrier, R; Shimakawa, S; Sparrow, JC; Walker, KR | 1 |
| Funae, Y; Hanioka, N; Hichiya, H; Imoto, K; Isobe, T; Kiryu, K; Naito, S; Narimatsu, S; Yamamoto, S | 1 |
| Chen, CM; Chen, ST; Lee-Chen, GJ; Lin, CY; Lin, TC; Ro, LS; Wu, YR | 1 |
| Brenner, MC; Hirsilä, M; Kivirikko, KI; Koivunen, P; Li, D; Myllyharju, J; Xu, L; Yang, C | 1 |
| Craik, CS; Kisiel, W; Mahrus, S | 1 |
| Gertz, MA; Murphy, CL; Solomon, A; Wang, S; Weaver, K; Weiss, DT | 1 |
| Damiani, D; de Menezes Filho, HC; Hauache, OM; Kunii, I; Manna, TD; Miyashiro, K; Setian, N | 1 |
| Catterall, WA; Scheuer, T; Zhao, Y | 1 |
| Kentsis, A; Miller, F; Osman, R; Pan, ZQ | 1 |
| Ducharme, L; Khoury, K; LeHoux, JG | 1 |
| Liaw, YC; Lin, SC; Lo, YC; Shaw, JF | 1 |
| Colquhoun, D; Shelley, C | 1 |
| London, E; Zhao, G | 1 |
| Jaakkola, U; Jartti, T; Kallio, J; Koulu, M; Kuusela, T; Pesonen, U; Vahlberg, T | 1 |
| Berman, Z; Leshinsky-Silver, E; Lev, D; Vinkler, C; Yannov-Sharav, M | 1 |
| Bray, PF; Ito, M; Liu, Y; Sun, W; Vijayan, KV | 1 |
| Homoki, J; Moisan, AM; Peter, M; Schwab, KO; Simard, J | 1 |
| Ahn, T; Kim, S; Park, C | 1 |
| Chang-Claude, J; Wang-Gohrke, S | 1 |
| Catapano, D; D'Agruma, L; D'Angelo, VA; Guarnieri, V; Muscarella, LA; Zelante, L | 1 |
| Brismar, K; Ding, B; Efendic, S; Gu, HF; Kärvestedt, L; Nordman, S; Ostenson, CG | 1 |
| Alvarez, V; Batalla, A; Coto, E; García-Castro, M; González, P; Lozano, I; Montes, M; Ordóñez, AG; Palop, RL; Reguero, JR | 1 |
| Axelsson, CK; Bojesen, SE; Nordestgaard, BG; Tybjaerg-Hansen, A | 1 |
| Albericio, F; Castel, S; Farrera-Sinfreu, J; Giralt, E; Royo, M | 1 |
| Achermann, JC; Flück, CE; Leheup, B; Mallet, D; Maret, A; Morel, Y; Mullis, PE; Portrat-Doyen, S; Theintz, GE | 1 |
| Le, A; Lee, CM; Nguyen, Q; Reddy, EP | 1 |
| Fujisaki, M; Hashimoto, K; Iyo, M; Matsuzawa, D; Shimizu, E | 1 |
| Koelsch, R; Neubert, K; Stiebitz, B; Stöckel-Maschek, A | 1 |
| Babraj, JA; Crameri, RM; Døssing, S; Flyvbjerg, A; Hansen, M; Kjaer, M; Langberg, H; Miller, BF; Olesen, JL; Rennie, MJ; Smith, K; Welling, RJ | 1 |
| Fournier, F; Karoyan, P; Mezzache, S; Pepe, C; Tabet, JC | 1 |
| Floroskufi, P; Kalfakis, N; Karadima, G; Panas, M; Vassilopoulos, D | 1 |
| Kumar, TK; Sivaraja, V; Yu, C | 1 |
| Mechler, F; Molnar, MJ; Siska, E; Szabo, A; Züchner, S | 1 |
| Nout, MJ; Rombouts, FM; Thanh, NV | 1 |
| Hong, SJ; Wang, HZ; Wu, KY | 1 |
| Blaakaer, J; Bojesen, SE; Høgdall, CK; Høgdall, EV; Kjaer, SK; Nordestgaard, BG; Thomsen, BL; Tybjaerg-Hansen, A | 1 |
| Alexandrova, ES; Avalle, B; Friboulet, A; Gabibov, AG; Karavanov, A; Khaidukov, SV; Morse, HC; Ponomarenko, NA; Reshetnyak, AV; Telegin, GB; Thomas, D; Vorobiev, II | 1 |
| Chen, XS; Fletcher, RJ | 1 |
| Allen, D; Hao, Y; Kraft, TW; Peng, YW; Petters, RM; Wong, F | 1 |
| Baker, S; Matsuka, YV; Nunez, L; Severina, E | 1 |
| Alevra, X; Christodoulou, K; Georgiou, DM; Hadjisavvas, A; Kleopa, KA; Kyriakides, T; Nicolaou, P; Zamba-Papanicolaou, E | 1 |
| Aasly, JO; Farrer, MJ; Pielsticker, L; Ross, OA; Toft, M | 1 |
| Ben Yaou, R; Bonne, G; Decostre, V | 1 |
| Chang, MH; Demirci, FY; Gorin, MB; Mah, TS; Romero, MF | 1 |
| Chen, Y; Jiang, D; Sun, X; Wan, B; Yu, L | 1 |
| Itabashi, T; Kawamura, M; Nishida, K; Sato, H; Tada, A; Tamai, M; Wada, Y | 1 |
| Aleinikova, TD; Egorov, VV; Gasteva, AA; Shavlovsky, MM; Shvartsman, AL; Sirotkin, AK; Solovyov, KV | 1 |
| Frederiksen, K; Hansen, RD; Overvad, K; Raaschou-Nielsen, O; Sørensen, M; Tjønneland, A; Vogel, U | 1 |
| Burness, CE; Chinnery, PF; Cox, LE; Dalton, A; Hadjivassiliou, M; Hewamadduma, C; Kirby, J; McDermott, CJ; Rao, DG; Sharrack, B; Shaw, PJ | 1 |
| Caplan, L; Danilov, SM; Klockgether, T; Linnebank, M; Semmler, A; Stein, RW | 1 |
| Bennett, MJ; Narayan, SB; Park, JY | 1 |
| Bannister, ML; Casarotto, MG; Dulhunty, AF; Hamada, T; Harvey, PJ; Ikemoto, N; Murayama, T | 1 |
| Aboul-Enein, F; Baumann, N; Berger, J; Bernheimer, H; Colsch, B; Cox, T; Gieselmann, V; Krammer, M; Krivit, W; Lefevre, M; LeGuern, E; Moser, A; Moser, H; Olivier, C; Rauschka, H; Reuner, U; Schmidbauer, M; Tardieu, S; Turpin, JC; Tylki-Szymanska, A; Wevers, R; Zalc, B | 1 |
| Feng, G; Gao, J; He, L; Li, S; Li, X; Qian, X; Qin, W; Shu, A; Xing, Q; Zhang, J; Zheng, Y | 1 |
| Fojo, T | 1 |
| Gunning, PW; Ivery, MT; Kavallaris, M; Larsen, MR; Liaw, TY; Liu, ML; Marshall, GM; Po'uha, ST; Verrills, NM | 1 |
| Kato, Y; Kurita, J; Miyakawa, T; Tanokura, M | 1 |
| Antzelevitch, C; Barajas-Martinez, H; Brugada, J; Brugada, P; Brugada, R; Burashnikov, E; Cordeiro, JM; Dumaine, R; Hong, K; Hu, D; Orsino, AM; Pfeiffer, R; Wu, YS | 1 |
| Alvarez, V; Calatayud, MT; Corao, AI; Coto, E; García-Castro, M; González, P; Lahoz, CH; Martínez, C; Menéndez, M; Peña, J | 1 |
| Bertelli, M; Buda, A; Cecchin, S; Fabbri, A; Lapucci, C; Lorusso, L; Pandolfo, M; Sidoti, V | 1 |
| Chen, S; Deng, X; Ding, X; Dong, H; Li, W; Li, X; Ma, G; Wu, T; Yao, J; Zeng, Y; Zhang, X | 1 |
| Chen, W; Ding, W; Hu, Z; Hua, Z; Jin, G; Shen, H; Shen, J; Tan, Y; Wang, J; Wang, L; Wang, X; Xu, Y; Zhang, Z; Zhou, Y | 1 |
| Byrski, T; Edler, L; Górski, B; Gronwald, J; Hamann, U; Huzarski, T; Jakubowska, A; Lubinski, J; Menkiszak, J; Scott, RJ | 1 |
| Bajaj, SP; Bolton-Maggs, PH; Gailani, D; Schmidt, A; Sun, MF | 1 |
| Accardo, A; Bongiovanni, A; Candore, G; Caruso, C; Crivello, A; Di Noto, L; Forte, GI; Giacalone, A; Lio, D; Macaluso, MC; Palmeri, L; Palmeri, S; Raimondi, C; Scola, L; Vaglica, M; Verna, R | 1 |
| Bach-Mortensen, P; Bojesen, SE; Hyldstrup, L; Nordestgaard, BG; Tofteng, CL; Tybjaerg-Hansen, A | 1 |
| Kesäniemi, YA; Ukkola, O | 1 |
| Baulac, M; Baulac, S; Chabrol, E; Depienne, C; Gourfinkel-An, I; LeGuern, E; Popescu, C; Senechal, K; Trouillard, O | 1 |
| Holopainen, JM; Immonen, I; Kaarniranta, K; Kallio, J; Karvonen, MK; Koulu, M; Pesonen, U; Teräsvirta, M; Uusitalo, H | 1 |
| Allard, B; Berthier, C; Couchoux, H; Jacquemond, V; Legrand, C | 1 |
| Barrai, I; De Lorenzi, S; Salvatorelli, G; Scapoli, C | 1 |
| Kawaguchi, T; Narita, H; Nishino, N; Noguchi, K; Okuyama, K; Tanaka, Y | 1 |
| Bu, W; Carroll, KD; Lukac, DM; Palmeri, D | 1 |
| Brinen, LS; Collins, PR; Dalton, JP; Donnelly, S; Lowther, J; Stack, CM; Xu, W | 1 |
| Bettè, S; Bossi, E; Castagna, M; Cherubino, F; Giovannardi, S; Miszner, A; Peres, A | 1 |
| Anandan, B; Jayaraman, G; Karthikeyan, M; Rose, R | 1 |
| Christie, G; Lowe, CR | 1 |
| Lyle, EA; Mazur, DJ; Omueti, KO; Tapping, RI; Thompson, KS | 1 |
| Addo-Daaku, A; Giordano, PC; Harteveld, CL; Kok, PJ; Sander, MJ; van Delft, P; van Rooijen-Nijdam, I | 1 |
| Hanzawa, Y; Hiratsuka, M; Ishikawa, M; Mizugaki, M; Sasaki, T | 1 |
| Ge, J; Hou, F; Huang, S; Liu, B; Wang, L; Zhuo, Y | 1 |
| Jaakkola, U; Kallio, J; Karvonen, MK; Koulu, M; Pesonen, U; Seppälä, H; Vahlberg, T | 1 |
| Arora, RS; Mercer, J; Thornley, M; Tylee, K; Wraith, JE | 1 |
| Nieman, MT; Schmaier, AH | 1 |
| Lee, LC; Lee, YL; Liaw, YC; Shaw, JF | 1 |
| Ben Farhat, L; Ben Hariz, M; Ben M'barek, S; Briki, S; Halioui-Louhaïchi, S; Hendaoui, L; Maherzi, A; Mornet, E | 1 |
| Chandoga, J; Petrovic, R; Sutovský, S; Turcáni, P | 1 |
| Da, Y; Jia, J | 1 |
| Asuni, AA; Boutajangout, A; Quartermain, D; Sigurdsson, EM | 1 |
| Altshuler, D; Bell, DW; Daly, MB; Freedman, ML; Garber, JE; Godwin, AK; Haber, DA; Haiman, CA; Harris, PL; Haserlat, SM; Henderson, BE; Kim, SH; Le Marchand, L; Niendorf, KB; Olopade, OI; Schiripo, TA; Sgroi, DC; Smith, MR; Wahrer, DC | 1 |
| Campos-Mollo, E; Escribano, J; López-Garrido, MP; López-Martínez, F; López-Sánchez, E; Sánchez-Sánchez, F | 1 |
| Aldave, AJ; Chen, MC; Rayner, SA; Sonmez, B; Thonar, EJ; Yellore, VS | 1 |
| Drgonova, J; Hall, FS; Krieger, RM; Liu, QR; Uhl, GR | 1 |
| Graham, SC; Guss, JM | 1 |
| Brismar, K; Dahlquist, G; Efendic, S; Falhammar, H; Gu, HF; Ma, J; Möllsten, A; Nordman, S | 1 |
| Chikova, A; Dalal, S; Jaeger, J; Sweasy, JB | 1 |
| Ilveskoski, E; Karhunen, PJ; Lehtimäki, T; Mikkelsson, J; Pörsti, I; Viiri, LE | 1 |
| Annesi, F; Annesi, G; Carrideo, S; Cirò Candiano, IC; Civitelli, D; Condino, F; De Marco, EV; Messina, D; Morelli, M; Nicoletti, G; Novellino, F; Provenzano, G; Quattrone, A; Rocca, FE; Tarantino, P | 1 |
| Arino, T; Kawahara, Y; Maki, T; Takagi, N; Takeo, S; Tanonaka, K; Yagi, A | 1 |
| Cea, G; Davis, MB; Fialho, D; Hanna, MG; Haworth, A; Matthews, E; Stanley, E; Sud, R; Sweeney, MG; Tan, SV | 1 |
| Fan, YM; Kivelä, SL; Lehtimäki, T; Salminen, M; Vahlberg, T | 1 |
| Agabiti Rosei, E; Biasi, L; Gambera, A; Gregorini, G; Martini, PR; Scalvini, T; Scolari, F; Tardanico, R | 1 |
| Dressler, P; Hartmann, J; Meyer-Marcotty, P; Stellzig-Eisenhauer, A; Weisschuh, N | 1 |
| Bird, TD; Griffith, A; Leis, BC; Leverenz, JB; Mata, IF; Roberts, JW; Samii, A; Schellenberg, GD; Schneer, SH; Sidransky, E; Tsuang, D; Zabetian, CP | 1 |
| Gieselmann, V | 1 |
| Cox, CL; Secor, SM | 1 |
| Bock, H; Hilbig, A; Jardim, LB; Michelin-Tirelli, K; Rieder, CR; Saraiva-Pereira, ML; Socal, MP | 1 |
| Drac, H; Hausmanowa-Petrusewicz, I; Kabzińska, D; Kochański, A; Lupski, JR; Rowińska-Marcińska, K; Saifi, GM | 1 |
| George-Hyslop, PS; Hagiwara, H; Ikeda, M; Kawarabayashi, T; Matsubara, E; Murakami, T; Nakazato, Y; Sasaki, A; Shoji, M; Westaway, D | 1 |
| Amizuka, N; Hl Freitas, P; Ishida, Y; Li, M; Oda, K; Saito, N; Shimomura-Kuroki, J; Shimooka, S; Ubaidus, S | 1 |
| Ando, F; Iguchi, A; Kuzuya, M; Shimokata, H | 1 |
| Castillo, L; Roth, RM; Tharakan, JF; Young, VR; Yu, YM; Zurakowski, D | 1 |
| Bai, YJ; Duan, S; Ge, J; Lin, MK; Saragovi, HU; Wei, YT; Zhuo, YH | 1 |
| Baust, T; El Mestikawy, S; Haflett, JM; Hoffman, B; Parra, LA; Quiroz, M; Torres, GE; Yao, JK | 1 |
| Kang, SJ; Khang, SK; Ki, CS; Kim, DW; Kim, HY; Kim, SH; Koh, SH; Sung, IH | 1 |
| Chen, Y; Marciano, DC; Palzkill, T; Pennington, JM; Shoichet, BK; Thomas, VL; Wang, J; Wang, X | 1 |
| Hatano, K; Miyakawa, T; Sawano, Y; Tanokura, M | 1 |
| Cui, AM; Davenport, B; Garruto, RM; Go, RC; Heizer, JW; Hermosura, MC; Mocz, G; Perraud, AL; Schmitz, C; Shetler, CM | 1 |
| Kaipio, K; Pesonen, U | 1 |
| Douna, V; Kanavakis, E; Metaxotou-Mavrommati, A; Papassotiriou, I; Stamoulakatou, A; Traeger-Synodinos, J | 1 |
| Gong, W; Lin, Y; Liu, R; Wang, Y; Wei, Z; Xu, H | 1 |
| Arné-Bes, MC; Delisle, MB; Figarella-Branger, D; Heitz, F; Levade, T; Pellissier, JF; Richard, P; Uro-Coste, E | 1 |
| Aldea, M; Castillo, M; Criado, M; Gerber, S; Mulet, J; Sala, F; Sala, S | 1 |
| Weber, JT; Yin, TC | 1 |
| Groenewegen, HJ; Haber, SN; Klein, C; Lynd, E | 1 |
| Dornhoffer, J; Hartzell, LD; McKelvey, KD; Van Hemert, RL | 1 |
| Kaipio, K; Pesonen, U; Suominen, M; Vahlberg, T | 1 |
| Furuhashi, M; Miyazawa, T; Munegumi, T; Ozawa, A | 1 |
| Ercole, C; Mattia, CA; Merlino, A; Perillo, M; Picone, D; Russo Krauss, I; Sica, F; Vergara, A | 1 |
| Anderson, MD; Breidinger, SA; Woolf, EJ | 1 |
| Bonuccelli, G; Bryant, KG; Dasgupta, A; Jasmin, JF; Lisanti, MP; Mercier, I; Pestell, RG; Sotgia, F; Witkiewicz, AK | 1 |
| Inoue, I; Kang, EH; Maki, K; Nakajima, T; Park, SB; Tajima, A; Tomoyasu, Y; Watanabe, M; Yamaguchi, M; Yamaguchi, T | 1 |
| Duydu, Y; Gucyener, E; Kose, G; Sakalli, O; Suzen, HS; Uckun, Z; Ustel, D | 1 |
| Goyal, N; Hopkinson, B; Wang, G | 1 |
| Collin, OL; Cook, SL; Jackson, GP | 1 |
| Bousquet, O; Lauzon, M; Leclerc, N; Paiement, J; Perreault, S | 1 |
| Boehme, A; Brixner, V; Richter, R; Seidl, C; Seifried, E; Skrablin, PS | 1 |
| Muraki, A; Nishimura, Y; Park, SY; Shibuya, M; Takeuchi, F; Tsubaki, M | 1 |
| Hou, XW; Wang, LF; Wang, NF; Xu, HY; Xu, J | 1 |
| Brown, RL; Diamond, AM; Foster, CB; Goldberg, M; Herman, L; Lee, BS; Peters, U; Wang, H; Zhuo, P | 1 |
| Carroll, SS; Dimuzio, J; Fandozzi, C; Graham, DJ; Hazuda, D; Holloway, MK; Liverton, NJ; Ludmerer, SW; McCauley, JA; McIntyre, CJ; Olsen, DB; Rudd, MT; Stahlhut, M; Vacca, JP | 1 |
| Knight, CA | 1 |
| Di Francesco, ME; Koch, U; Pace, P; Pesci, S; Pompei, M; Summa, V; Veneziano, M; Vignetti, SE | 1 |
| Cattepoel, S; Eckert, A; Kuehnle, K; Kulic, L; Nitsch, RM; Pagani, L; Rhein, V; Tracy, J; Wollmer, MA | 1 |
| Cano-Abad, MF; García, AG; Moreno-Ortega, AJ; Ruiz-Nuño, A | 1 |
| Cao, L; Chen, SD; Cheng, Q; Cui, PJ; Deng, YL; Ding, JQ; Ma, JF; Tang, HD; Wang, G; Wang, Y; Xu, W; Zhang, T; Zheng, L | 1 |
| Agarwal, S; Gill, AC; Goldmann, W; Graham, JF; Kirby, L | 1 |
| Bernhardt, P; Cheeseman, JD; Jiang, Y; Kazlauskas, RJ; Morley, KL; Purpero, V; Schrag, JD; Yin, DL | 1 |
| Guo, JF; Pan, Q; Sun, QY; Tang, BS; Wang, L; Xia, K; Yao, LY; Yu, RH; Zuo, X | 1 |
| Bush, KJ; Butcher, JW; Carroll, SS; DiMuzio, JM; Fandozzi, CM; Gilbert, KF; Graham, DJ; Holloway, MK; Liverton, NJ; Ludmerer, SW; Mao, SS; McCauley, JA; McIntyre, CJ; Nguyen, KT; Olsen, DB; Romano, JJ; Rudd, MT; Stahlhut, MW; Swestock, J; Trainor, N; Vacca, JP; Wan, BL | 1 |
| Bettess, MD; Felquer, F; Hamra, N; Keough, RA; Lake, JA; Lonic, A; Morris, MB; Rathjen, J; Rathjen, PD; Semendric, L; Tan, BS; Washington, JM | 1 |
| Alegret, M; Antúnez, C; Boada, M; Carrasco, JM; Galán, JJ; González-Pérez, A; Hernández, I; López-Arrieta, J; Marín, J; Martínez-Lage, P; Moreno, C; Morón, FJ; Real, LM; Ruiz, A; Tárraga, L | 1 |
| Bagnoli, S; Bessi, V; Bracco, L; Cellini, E; Guarnieri, BM; Lucenteforte, E; Nacmias, B; Piaceri, I; Sorbi, S; Tedde, A | 1 |
| Area, E; Artuch, R; Cormand, B; Drakaki, K; Garcia-Cazorla, A; Giannakopoulos, A; Kanavakis, E; Orfanou, I; Ormazabal, A; Pons, R; Ribasés, M; Serrano, M; Toma, C; Youroukos, S | 1 |
| Arasappan, A; Bennett, F; Chase, R; Feld, B; Guo, Z; Hart, A; Madison, V; Malcolm, B; Njoroge, FG; Pichardo, J; Prongay, A; Ralston, R; Skelton, A; Tong, X; Xia, E; Zhang, R | 1 |
| Brans, A; Di Paolo, A; Frère, JM; Lejeune, A; Matagne, A; Schmid, FX; Vandenameele, J | 1 |
| Burroughs, L; Clarke, PA; Forintos, H; Gilks, JA; Hayes, CJ; Vale, ME | 1 |
| Mensink, RP; Popeijus, HE; van Meijl, LE | 1 |
| Bista, P; Götz, J; Köhler, C; Schröder, H | 1 |
| Bertini, E; Bushby, K; D'Amico, A; Goldfarb, LG; Lee, HS; Lochmüller, H; McKenna, C; Odgerel, Z; Paola, F; Rankin, J; Sarkozy, A; Straub, V | 1 |
| Bailey, MD; Bhardwaj, PK; Bordeleau, J; Bös, M; Bousquet, Y; Cordingley, MG; Duan, J; Forgione, P; Garneau, M; Ghiro, E; Gorys, V; Goudreau, N; Goulet, S; Halmos, T; Kawai, SH; Llinàs-Brunet, M; Naud, J; Poupart, MA; White, PW | 1 |
| Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Kukolj, G; Lagacé, L; Llinàs-Brunet, M; Thibeault, D; White, PW | 1 |
| Clement, RP; Cunliffe, JM; Dreyer, DP; Hayes, RN; Shen, JX | 1 |
| Bowler, BE; Finnegan, ML | 1 |
| Bae, A; Chen, X; Harris, J; Ku, K; Miller, MD; Mo, H; Qi, X; Sun, SC; Wong, KA; Worth, A | 1 |
| Bergmann, JF; de Bruijne, J; de Knegt, RJ; Hughes, EA; Janssen, HL; Li, J; Molenkamp, R; Reesink, HW; Schinkel, J; Tong, X; Treitel, MA; van Lier, JJ; van Vliet, AA; Weegink, CJ | 1 |
| Jacobi, MN; Jensen, CH; Nerukh, D; Ruzhytska, S | 1 |
| Albertini, JP; Bonnefont-Rousselot, D; Charnaux, N; Charniot, JC; Cosson, C; Giral, P; Khani-Bittar, R; Sutton, A | 1 |
| Carroll, SS; Davies, ME; Graham, D; Handt, L; Hazuda, D; Koeplinger, K; Liverton, N; Ludmerer, SW; MacCoss, M; Olsen, DB; Zhang, NR | 1 |
| Benhamou, Y; Berg, T; Boecher, WO; Bonacini, M; Bourlière, M; Calleja, JL; Kukolj, G; Manns, MP; Pol, S; Scherer, J; Steinmann, G; Stern, JO; Trepo, C; White, PW; Wright, D; Yong, CL | 1 |
| Kaminnyi, AI; Kukharchuk, VV; Meshkov, AN; Shuvalova, YA | 1 |
| Ciano, C; Di Fede, G; Fancellu, R; Mariotti, C; Nanetti, L; Pareyson, D; Politi, LS; Salsano, E; Scaioli, V; Tagliavini, F | 1 |
| Hoshino, A; Kaewkhampa, A; Kantaputra, PN; Lees, M; Masrour, N; McEntagart, M; Moore, GE; Paramee, M; Pauws, E; Stanier, P | 1 |
| Goudreau, N; Hucke, O; Lemke, CT; Llinàs-Brunet, M; Thibeault, D; White, PW; Zhao, S | 1 |
| Gregersen, S; Hermansen, K; Jeppesen, PB; Liu, Z; Luo, Y | 1 |
| Drozdzik, M; Dziewanowski, K; Kozak, M; Kurzawski, M; Lapczuk, J; Lipski, M; Wajda, A | 1 |
| Azam, M; Collin, RW; Cremers, FP; den Hollander, AI; Hussain, A; Kersten, FF; Keunen, JE; Khan, MI; Kremer, H; Qamar, R; Shah, ST | 1 |
| Dai, ZL; Li, XL; Wu, G; Xi, PB; Zhang, J; Zhu, WY | 1 |
| Hwang, GS; Kim, CW; Kim, EJ; Kim, HJ; Kim, JS; Yang, JY | 1 |
| Attems, J; Götz, J; Heikenwalder, M; Ittner, A; Jellinger, K; Maj, M; Nitsch, RM; Wagner, L | 1 |
| Clement, RP; Cunliffe, JM; Dreyer, DP; Hayes, RN; Shen, JX; Wei, X | 1 |
| Feng, M; Gao, J; Gu, C; Han, R; Liu, H; Long, Y; Ma, S; Mi, H; Wang, Y | 1 |
| Asher, SA; Burger, VM; Chong, LT; Myshakina, NS; Xiong, K; Zwier, MC | 1 |
| Armenio, A; Giglietto, D; Maggio, G; Pascone, M; Ribatti, D; Ruccia, F | 1 |
| Arjomand, A; Chowdhury, SK; Gao, L; Hesk, D; Kasserra, C; Li, J; Song, Q | 1 |
| Adamowicz, DH; Carlson, GA; Fox, LM; Hyman, BT; Pitstick, R; Spires-Jones, TL; William, CM | 1 |
| Michikawa, T; Mikoshiba, K; Nishizawa, M; Nozaki, H; Onodera, O; Yamazaki, H | 1 |
| Bukh, J; Ghanem, L; Gottwein, JM; Jensen, TB; Scheel, TK | 1 |
| Abdul, HM; Butterfield, DA; Cai, J; Di Domenico, F; Markesbery, WR; Pierce, WM; Robinson, RA; St Clair, DK; Sultana, R | 1 |
| Khungar, V; Poordad, F | 1 |
| Belyk, KM; Davies, IW; Devine, PN; Dormer, PG; Humphrey, G; Journet, M; Kuethe, JT; Lieberman, D; Nolting, A; Peng, Z; Reamer, RA; Song, ZJ; Tellers, DM; Tschaen, DM; Waters, MS; Zewge, D; Zhang, F; Zhao, D | 1 |
| Ciesek, S; Manns, MP; von Hahn, T | 1 |
| Angus, P; Arasteh, K; Asselah, T; Boecher, WO; Bronowicki, JP; Gane, E; Haefner, C; Heim, M; Kukolj, G; Larrey, D; Lohse, A; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F | 1 |
| Duan, X; Mao, T; Wang, W; Xue, Y | 1 |
| Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; De Marte, J; Duan, J; Garneau, M; Jutras, M; Llinàs-Brunet, M; Montpetit, H; Otis, F; Rhéaume, M; White, PW; Yong, CL | 1 |
| Bousquet, C; Dansereau, N; Dô, F; Kukolj, G; Lagacé, L; Llinas-Brunet, M; Marquis, M; Massariol, MJ; Maurice, R; Spickler, C; Thibeault, D; Triki, I; White, PW; Zhao, S | 1 |
| Lok, AS; Sharma, P | 1 |
| Chen, A; Diaz-Ruiz, C; Ho, L; Ksiezak-Reding, H; Pasinetti, GM; Santa-Maria, I; Wang, J | 1 |
| Borghgraef, P; Demedts, D; Devijver, H; Kremer, A; Maurin, H; Van Leuven, F | 1 |
| Chen, T; Corcoran, NM; Grundy, R; Hovens, CM; Jones, NC; Nguyen, T; O'Brien, TJ; Velakoulis, D | 1 |
| Chen, JH; Huang, ZR; Liu, HY; Zhu, SJ | 1 |
| Hou, T; Li, Y; Mao, X; Yu, H; Zhang, L; Zhu, J | 1 |
| Akhlaghi, S; Dehghan-Manshadi, R; Ferns, GA; Forghanifard, MM; Ghayour-Mobarhan, M; Jamialahmadi, K; Masoudi-Kazemabad, A; Mojarrad, M; Moohebati, M | 1 |
| Alsaleh, A; Frost, GS; Griffin, BA; Jebb, SA; Lovegrove, JA; O'Dell, SD; Sanders, TA | 1 |
| Balsells-Padros, J; Cao, Y; Chen, CY; Dolman, SJ; Dunn, RF; Janey, J; Kong, J; Li, H; Zacuto, MJ | 1 |
| Barnard, RJ; Caro, L; Gane, E; Hwang, PM; Lee, AW; Manns, MP; Marcellin, P; Rodriguez-Torres, M; Stoehr, A; Wiedmann, RT; Yeh, CT | 1 |
| Bhat, RG; Mohite, AR | 1 |
| Cardoso, BR; Cominetti, C; Cozzolino, SM; Freitas, MI; Jacob-Filho, W; Jaluul, O; Ong, TP | 1 |
| Bauer, M; Borte, M; Gräbsch, C; Heinrich, J; Herbarth, O; Illig, T; Klopp, N; Krämer, U; Lehmann, I; Röder, S; Schaaf, B; Schlink, U; von Berg, A | 1 |
| Doi, T; Fukushima-Uesaka, H; Fuse, N; Hamaguchi, T; Ishii-Watabe, A; Kaniwa, N; Kato, K; Kawasaki, N; Kurose, K; Maekawa, K; Matsumura, Y; Muro, K; Nakajima, TE; Ohtsu, A; Okuda, H; Saijo, N; Saito, M; Saito, Y; Sawada, J; Shimada, Y; Suzuki, T; Tada, M; Ura, T; Yamada, Y; Yoshida, T; Yoshino, T | 1 |
| Ali, A; Aydin, C; Cao, H; Deveau, LM; Huang, W; Newton, A; Ozen, A; Petropoulos, CJ; Romano, KP; Schiffer, CA; Silver, C; Soumana, D | 1 |
| Artemenko, KA; Bergquist, J; Bergström Lind, S; Elfineh, L; Pettersson, U; Zhao, Y | 1 |
| Britschgi, M; Johns, H; Masliah, E; Rockenstein, E; Takeda-Uchimura, Y; Wyss-Coray, T | 1 |
| Augustin, J; Ayrignac, X; Campion, D; Clanet, M; Coutant, S; Defebvre, L; Frébourg, T; Guyant-Maréchal, L; Hannequin, D; Krystkowiak, P; Labauge, P; Le Ber, I; Lefaucheur, R; Legallic, S; Maltête, D; Martinaud, O; Nicolas, G; Pariente, J; Pottier, C; Rousseau, S; Rovelet-Lecrux, A; Vaschalde, Y | 1 |
| Anderson, KC; Arcaini, L; Brown, JR; Cao, Y; Greco, A; Hunter, ZR; Lindeman, NI; Liu, X; Manning, RJ; Morra, E; Munshi, NC; Patterson, CJ; Tai, YT; Treon, SP; Tripsas, CK; Trojani, A; Varettoni, M; Xu, L; Yang, G; Zhou, Y | 1 |
| Arcaini, L; Bonfichi, M; Boveri, E; Cazzola, M; Corso, A; Croci, G; Fiaccadori, V; Gotti, M; Guerrera, ML; Mangiacavalli, S; Morello, L; Orlandi, E; Pascutto, C; Paulli, M; Rattotti, S; Riboni, R; Varettoni, M; Zibellini, S | 1 |
| Asselah, T; Bessone, F; Böcher, WO; Datsenko, Y; Fainboim, H; Ferenci, P; Heo, J; Kukolj, G; Lalezari, J; Leggett, B; Mauss, S; Nehmiz, G; Scherer, J; Steinmann, GG; Stern, JO; Sulkowski, MS | 1 |
| Bellomo, G; Camaro, C; De Luca, G; Di Giovine, G; Marino, P; Pergolini, P; Restifo, M; Rolla, R; Schaffer, A; Suryapranata, H; Verdoia, M | 1 |
| An, D; Barnard, RJ; Bhanja, S; Gane, EJ; Gress, J; Hwang, P; Lawitz, E; Mobashery, N; Rodriguez-Torres, M; Serfaty, L; Stoehr, A | 1 |
| Haber, SN; Haynes, WI | 1 |
| Boonstra, A; de Bruijne, J; de Knegt, RJ; Hotho, DM; Janssen, HL; Reesink, HW; Spaan, M; Treitel, MA | 1 |
| Liu, S; Su, M; Wei, M; Zhou, Z | 1 |
| Angus, P; Arasteh, K; Asselah, T; Böcher, WO; Bronowicki, JP; Gane, E; Heim, M; Kukolj, G; Larrey, D; Lohse, AW; Mensa, FJ; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F | 1 |
| Beck, J; Downey, LE; Liang, Y; Mahoney, CJ; Mead, S; Perry, RJ; Warren, JD | 1 |
| Aragona, P; Micali, A; Postorino, E; Puzzolo, D; Rania, L; Roszkowska, AM; Spinella, R | 1 |
| Hashemi, M; Heidari, Z; Mahmoudzadeh-Sagheb, H; Rigi-Ladiz, MA | 1 |
| Guillemin, JC; Kukhar, VP; Sorochinsky, AE; Tarasevych, AV | 1 |
| Ates, O; Cumurcu, BE; Demir, S; Gul, IG; Karlıdag, R; Ozyurt, H | 1 |
| Ban, Y; Liu, H; Xue, W; Yao, X | 1 |
| Al-Ibrahim, M; Barnard, R; Caro, L; Gordon, SC; Gress, J; Hwang, PM; Jacobson, I; Kraft, WK; Kwo, P; Lawitz, E; Maliakkal, B; Miller, M; Mobashery, N; Panorchan, P; Quirk, E; Rockstroh, JK; Sulkowski, M | 1 |
| Barnard, RJ; Cheney, CA; Dinubile, MJ; Graham, DJ; Hazuda, DJ; Himmelberger, AL; Hwang, PM; McHale, CM; Mobashery, N; Newhard, W; Nickle, D; Reeves, JD; Rivera, AA; Strizki, J | 1 |
| Chiles, PG; Guan, HS; Li, S; Marsh, JJ; Morris, TA; Tran, D | 1 |
| Berger, KL; Bethell, R; Cartier, M; Kukolj, G; Lagacé, L; Lawetz, C; Marquis, M; Scherer, J; Triki, I | 1 |
| Engelbarth, S; Javela, K; Perola, M; Puurunen, M; Salo, P | 1 |
| Asselah, T; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Kukolj, G; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Vinisko, R; Zeuzem, S | 1 |
| Kuboki, M; Nishiguchi, S; Omata, M; Sakai, Y; Sakamoto, W; Steinmann, G; Tsuda, Y; Tsunematsu, S; Urano, Y | 1 |
| Brea, JM; Caamaño, O; Cadavid, MI; Fernández, F; Ferreira da Costa, J; García-Mera, X; Sampaio-Dias, IE | 1 |
| Ceballos, C; Dickson, DW; Hyman, BT; Lin, WL; Polydoro, M; Ren, Y; Sahara, N; Sanchez, L; Spires-Jones, TL | 1 |
| Haraguchi, T; Honda, K; Ito, K; Shoji, N; Wanikawa, Y; Yamamoto, K | 1 |
| Barnard, RJ; Bhanja, S; Bourque, M; DiNubile, MJ; Gane, EJ; Hwang, PM; Lawitz, E; Mobashery, N; Rodriguez-Torres, M; Serfaty, L; Stoehr, A; Strizki, J; Zhou, A | 1 |
| Bergmann, JF; de Bruijne, J; de Knegt, RJ; Hughes, E; Janssen, HL; Molenkamp, R; Rebers, SP; Reesink, HW; Schinkel, J; Thomas, XV; Treitel, MA; Weegink, CJ | 1 |
| Bichoupan, K; Dieterich, DT; Martel-Laferrière, V | 1 |
| Berger, KL; Böcher, WO; Cartier, M; Datsenko, Y; Kukolj, G; Marquis, M; Massariol, MJ; Scherer, J; Steinmann, G; Stern, JO; Triki, I | 1 |
| Cutello, S; Di Dio, G; La Rosa, M; Leonardi, S; Parisi, GF; Rotolo, N | 1 |
| Busacca, CA; Gonnella, N; Li, Y; O'Brien, D; Ramsden, D; Taub, ME; Tweedie, DJ; Xu, J; Zhou, J | 1 |
| Laufer, NL; Rockstroh, JK | 1 |
| Chan, TS; Li, Y; Ramsden, D; Taub, ME; Tweedie, DJ | 1 |
| Chen, LZ; Li, Y; Ramsden, D; St George, R; Tweedie, DJ | 1 |
| Boccaccio, V; Bruno, S | 1 |
| Dieterich, DT; Martel-Laferrière, V | 1 |
| Asselah, T; Marcellin, P | 1 |
| Asselah, T; Halfon, P; Marcellin, P; Schinazi, R | 1 |
| Benhamou, Y; Shiffman, ML | 1 |
| Ford, N; Fortunak, J; Hill, A; Khoo, S; Simmons, B | 1 |
| Albano, F; Anelli, L; Brunetti, C; Casieri, P; Cellamare, A; Coccaro, N; Impera, L; Minervini, A; Minervini, CF; Ricco, A; Specchia, G; Tota, G; Zagaria, A | 1 |
| Chen, LZ; Huang, F; Latli, B; Li, Y; Mandarino, D; Mao, Y; Rose, P; St George, R; Yong, CL | 1 |
| Shiffman, ML | 1 |
| Adamski, J; Gieger, C; Illig, T; Kastenmüller, G; Meisinger, C; Mook-Kanamori, DO; Peters, A; Petersen, AK; Prehn, C; Römisch-Margl, W; Suhre, K; Wang-Sattler, R | 1 |
| Asselah, T; Berg, T; Böcher, WO; Datsenko, Y; Dieterich, D; Ferenci, P; Guyader, D; Larrey, D; Maieron, A; Mauss, S; Ozan, M; Ratziu, V; Schuchmann, M; Steinmann, G; Stern, JO | 1 |
| Tan, SJ; Wang, BY | 1 |
| Agarwal, K; Austin, A; Barclay, ST; Brown, A; Dillon, JF; Dundas, P; Dusheiko, GM; Foster, GR; Fox, R; Hayes, PC; Leen, C; Miller, MH; Millson, C; Ryder, SD; Tait, J; Ustianowski, A | 1 |
| Chen, L; George, RS; Mao, Y; Norris, SH; Philip, E; Potchoiba, MJ; Wang, LQ; Wu, D | 1 |
| Böcher, WO; Hennecke, N; Kayser, A; Kukolj, G; Lohmann, V; Martin, B; Neumann-Haefelin, C; Thimme, R | 1 |
| Anthonappa, RP; King, NM; Rabie, AB; Yan-Hui, F; You-Qiang, S | 1 |
| Furusyo, N; Hayashi, J; Hiramine, S; Mitsumoto, F; Murata, M; Ogawa, E; Shimizu, M; Takayama, K; Toyoda, K; Ura, K | 1 |
| Khodayari, S; Sabet, EE; Salehi, Z; Zahiri, Z; Zarafshan, SS | 1 |
| Hall, MN; Jozefczuk, S; Rudroff, F; Sauer, U; Stracka, D | 1 |
| Ikeda, H; Linhoff, M; Mott, M; Ono, F; Park, JY; Wen, H; Williams, T | 1 |
| Ballow, C; Battegay, M; Elgadi, M; Feifel, U; Fuhr, R; Girlich, B; Haschke, M; Kort, J; Lang, B; Li, Y; Sabo, JP; Schobelock, M | 1 |
| Hayashi, N; Izumi, N; Mobashery, N | 1 |
| Acker, C; Azose, M; Buthorn, J; D'Abramo, C; Davies, P; Greenwald, BS; Jimenez, H; Koppel, J; Lesser, M; Lewis, J; Liu, Z | 1 |
| Chen, BZ; Geng, L; Ji, M; Wang, H | 1 |
| Asselah, T; Böcher, WO; Huang, Q; Li, Y; Mease, K; Nehmiz, G; Olson, S; Podila, L; Sane, RS; Steinmann, GG; Stern, JO; Taub, ME; Tweedie, D | 1 |
| Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Gallivan, JP; Mantry, P; Mensa, FJ; Soriano, V; Stern, JO; Taunk, J; Vinisko, R; Zeuzem, S | 1 |
| Elgadi, M; Halabi, A; Huang, F; Lang, B; Moschetti, V; Petersen-Sylla, M; Yong, CL | 1 |
| Elgadi, M; Garcia, J; Huang, F; Joseph, D; Rose, P; Schultz, A; Strelkowa, N | 1 |
| Irfanoglu, MO; Leopold, DA; Modi, P; Pierpaoli, C; Saleem, KS; Thomas, C; Ye, FQ | 1 |
| Adeniji, A; Elgadi, M; Huang, F; Joseph, D; Riesenberg, RR; Schobelock, MJ; Vince, BD; Webster, LR | 1 |
| Elgadi, M; Huang, F; Lang, B; Sabo, JP | 1 |
| Farrell, M; Hardiman, O; Lefter, S; McLaughlin, RL; Murphy, SM; Ryan, AM | 1 |
| Ballow, C; Battegay, M; Chan, TS; Cooper, C; Girlich, B; Haschke, M; Kashuba, AD; Kort, J; Lang, B; Li, Y; O'Brien, D; Sabo, JP; Seibert, E; Ting, N; Tweedie, D; Zhang, W | 1 |
| Koay, ES; Liu, TC; Poon, KS; Tan, KM | 1 |
| Chekulaeva, AM; Demenev, SV; Khadyeva, MN; Khamidullina, GF; Lifanov, AD; Rakhmatullina, LSh; Sofronova, EM | 1 |
| Bull, K; Fontana, M; Gandhi, S; Gilbertson, JA; Gillmore, JD; Hawkins, PN; Holton, JL; Jaunmuktane, Z; McColgan, P; Pinney, J; Reilly, MM; Rowczenio, D; Schott, JM; Shah, S; Sheikh, F; Tudor, R; Viegas, S; Werring, DJ; Whelan, CJ | 1 |
| Angus, P; Asselah, T; Böcher, W; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Manns, M; Mensa, FJ; Müllhaupt, B; Roberts, S; Sabo, JP; Schuchmann, M; Soriano, V; Stern, JO; Stickel, F; Voss, F; Zeuzem, S | 1 |
| Dickemann, N; Duffert, CM; Gehring, NH; Kerber, C; Klotter, AC; Kuhlee, IN; Kulozik, AE; Stockklausner, C | 1 |
| Agarwal, K; Asselah, T; Bourlière, M; Calinas, F; Crespo, J; Datsenko, Y; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; Garcia, M; Kukolj, G; Maevskaya, M; Morano, LE; Moreno, C; Nishiguchi, S; Omata, M; Ouzan, D; Quinson, AM; Sarrazin, C; Scherer, J; Schuchmann, M; Stern, JO; Zehnter, E; Zeuzem, S | 1 |
| Agarwal, K; Barnabas, A | 1 |
| Arastéh, K; Bhagani, S; Dieterich, D; Guardiola, JM; Ingiliz, P; Jain, MK; Kort, J; Laguno, M; Manero, M; Nelson, M; Rockstroh, JK; Soriano, V; Stern, JO; Tural, C; Vinisko, R | 1 |
| Kanda, T; Omata, M; Yokosuka, O | 1 |
| Anderson, M; Caro, L; Cerra, M; Du, L; Manns, MP; Nachbar, RB; Panorchan, P; Potthoff, A; Talal, AH; Wagner, J; Wright, DH | 1 |
| Fukada, R; Kugimiya, A | 1 |
| Ishida, Y; Komaru, K; Numa-Kinjoh, N; Oda, K; Sohda, M | 1 |
| Campagna, D; Demma, S | 1 |
| Ambrosioni, J; Aouri, M; Böni, J; Cavassini, M; Decosterd, L; Fehr, J; Furrer, H; Günthard, HF; Haubitz, S; Kovari, H; Ledergerber, B; Metzner, KJ; Rauch, A; Schaerer, V; Schmid, P; Stoeckle, M | 1 |
| Berger, KL; Kukolj, G; Quinson, AM; Ranga, M; Scherer, J; Sha, N; Stern, JO | 1 |
| Iwasa, T; Kinoshita, K; Nakamura, K; Takase, A | 1 |
| Hayashi, N; Howe, AY; Kumada, H; Ludmerer, SW; Mobashery, N; Nakamuta, M; Takase, A; Takehara, T | 1 |
| Chen, S; He, S; Huang, Y; Shi, Y; Wu, Y; Xia, M; Xu, C; Xu, J; Zang, W; Zhang, J; Zhao, T | 1 |
| Abe, H; Aikata, H; Chayama, K; Ellis, JD; Hayes, CN; Hiraga, N; Imamura, M; Ishida, Y; Kan, H; Miyaki, E; Tateno, C; Tsuge, M; Uchida, T; Yoshimi, S | 1 |
| Asselah, T; Bourlière, M; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; García-Samaniego, J; Maevskaya, M; Mantry, P; Oliveira, C; Quinson, AM; Sha, N; Stern, JO; Warner, N; Wright, D; Wright, M; Yoshida, EM | 1 |
| Liang, T; Lu, Y; Meng, T; Qin, C; Wang, S | 1 |
| Asselah, T; Baum, P; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Voss, F; Zeuzem, S | 1 |
| Gruca, A; Grynberg, M; Plewczynski, D; Tatjewski, M | 1 |
| Asatryan, A; Box, TD; Campbell, A; Freilich, BL; Kort, J; Lawitz, EJ; Lin, CW; Liu, W; Lovell, S; Ng, TI; O'Riordan, WD; Overcash, JS; Yao, B | 1 |
| Bănescu, C; Benedek Lazar, E; Cândea, M; Crauciuc, A; Dobreanu, M; Duicu, C; Iancu, M; Moldovan, VG; Trifa, AP; Tripon, F | 1 |
| Takehara, T | 1 |
| Baker, ME; Livelo, C; Mani, O; Nashev, LG; Odermatt, A | 1 |
| Chayama, K; Fujimoto, G; Howe, AY; Karino, Y; Kumada, H; Ludmerer, SW; Mobashery, N; Mochida, S; Nakamura, K; Suzuki, F | 1 |
| Black, S; Chang, W; Hayashi, N; Hirano, T; Howe, AY; Kumada, H; Ludmerer, SW; Nakamura, K; Nickle, D; Takase, A; Tanaka, Y | 1 |
| Oner, DA; Tastan, H | 1 |
| An, D; Brainard, DM; Di Bisceglie, AM; Dvory-Sobol, H; Freilich, B; Glass, S; Hassman, D; Hill, J; Kim, S; Kirby, BJ; Krefetz, D; Lawitz, E; Marbury, T; Rodriguez-Torres, M; Smith, W; Stamm, LM; Taylor, JG; Yang, JC | 1 |
| Abecasis, G; Alam, DS; Amouyel, P; Arveiler, D; Blankenberg, S; Butterworth, AS; Chowdhury, R; Cuchel, M; Danesh, J; De Craen, A; Deloukas, P; DerOhannessian, S; Di Angelantonio, E; Erdmann, J; Ferrario, M; Ferrieres, J; Ford, I; Hancock-Cerutti, WF; Howson, JM; Jukema, JW; Kathiresan, S; Kee, F; Khetarpal, SA; Kontush, A; Kuulasmaa, K; Larach, DB; Liu, DJ; Majumder, Aa; Männistö, S; Millar, JS; Müller-Nurasyid, M; Nielsen, SF; Nordestgaard, BG; Packard, C; Peloso, GM; Perola, M; Rader, DJ; Saleheen, D; Salomaa, V; Samani, N; Sattar, N; Schmidt, RF; Schunkert, H; Stitziel, NO; Surendran, P; Trompet, S; Tybjærg-Hansen, A; Willer, CJ; Zanoni, P | 1 |
| Castillo, JJ; Ghobrial, IM; Treon, SP | 1 |
| Imaizumi, N; Kashiwagi, T; Kashiwamura, S; Kishida, Y; Tanimura, H | 1 |
| Elgadi, M; Gießmann, T; Huang, F; Lang, B; Wu, J | 1 |
| Angus, P; Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Kadus, W; Mantry, P; Mensa, FJ; Pockros, PJ; Soriano, V; Stern, JO; Vinisko, R; Wright, D; Zeuzem, S | 1 |
| Fajkusová, L; Freiberger, T; Pavloušková, J; Réblová, K; Tichý, L | 1 |
| Edwards, PA; Tarling, EJ | 1 |
| Busacca, CA; Davis, M; Ding, A; Gonnella, NC; Grupe, J; Herfurth, L; Jones, PJ; Li, G; Niemann, M; Offerdahl, T; Reckzügel, G; Reddig, T; Roos, H; Saha, A; Wagner, K; Werthmann, U; Wu, JP; Zhang, L | 1 |
| Brainard, DM; Gane, EJ; Hyland, RH; McHutchison, JG; Schwabe, C; Stamm, LM; Stedman, CA; Svarovskaia, E; Yang, Y | 1 |
| An, R; Chen, Y; Tian, S; Xu, Y; Yang, X; Zhao, Q; Zheng, J | 1 |
| Chen, H; Chen, Z; Da, Y; Di, L; Liu, Z; Previch, L; Wang, W | 1 |
| Inoue, Y; Kato, H; Kobayashi, H; Suzuki, H; Suzuki, K | 1 |
| Arrieta-Cruz, I; Gutiérrez-Juárez, R | 1 |
| Aguilar, H; Asatryan, A; Gane, E; Hassanein, T; Kort, J; Kwo, PY; Lalezari, J; Lin, CW; Liu, R; Maliakkal, B; Mensa, FJ; Ng, TI; Poordad, F; Wang, S; Wyles, DL | 1 |
| Beavers, K; Bernstein, D; Brainard, DM; Chung, RT; Davis, M; Dvory-Sobol, H; Etzkorn, K; Everson, G; Gane, EJ; Gordon, SC; Khalid, O; Kowdley, KV; Kwo, PY; Lu, S; McHutchison, JG; Nguyen, MH; Poulos, JE; Pound, D; Rodriguez-Torres, M; Stamm, LM; Stedman, CA; Tong, M; Tsai, N; Yang, JC | 1 |
| Bennett, M; Brainard, DM; Curry, M; Dvory-Sobol, H; Hawkins, T; Herring, R; Hinestrosa, F; Jacobson, I; Lawitz, E; Lu, S; McHutchison, JG; Nahass, R; Pearlman, B; Rabinovitz, M; Reau, N; Reddy, KR; Schiff, E; Sheikh, A; Shiffman, M; Stamm, LM; Tran, T; Yang, JC; Younes, Z | 1 |
| Berger, KL; Côté-Martin, A; Kukolj, G; Marquis, M; Mensa, FJ; Nelson, DR; Sarrazin, C; Scherer, J; Sha, N; Stern, JO; Vinisko, R | 1 |
| Cheng, L; Li, JY; Li, NN; Lu, ZJ; Peng, R; Sun, XY; Tan, EK; Wang, L; Zhang, JH | 1 |
| Hannongbua, S; Kungwan, N; Meeprasert, A; Rungrotmongkol, T | 1 |
| Barayuga, SM; Bellinger, FP; Bellinger, MT; Berry, MJ; Dewing, AS; Kiyohara, AC; Moreira, PI; Perry, G; Rueli, RH; Torres, DJ; Uyehara-Lock, JH; White, LR | 1 |
| Asatryan, A; Campbell, A; Chiu, YL; Clifton, J; Dutta, S; Lin, CW; Liu, W; Wang, H | 1 |
| Bai, X; Calleja, JL; Forns, X; Garcia-Samaniego, J; Kaste, R; Manns, M; Sarrazin, C; Stern, JO; Wu, J | 1 |
| Asatryan, A; Bernstein, DE; Felizarta, F; Flamm, SL; Fried, MW; Gordon, SC; Kort, J; Landis, CS; Lin, CW; Liu, R; Lovell, SS; Mensa, FJ; Ng, TI; Poordad, F; Reindollar, RW; Sulkowski, MS | 1 |
| Abbar, M; Al Bouzidi, A; Ameur, A; Ameziane El Hassani, R; Attaleb, M; Dakka, N; El Mzibri, M; Hadami, K | 1 |
| Han, JY; Jee, SH; Kim, M; Lee, JH; Lee, SH | 1 |
| Brainard, DM; Dvory-Sobol, H; Gutierrez, J; Hyland, RH; Landaverde, C; Lawitz, E; McHutchison, JG; Poordad, F; Stamm, LM; Wells, J; Yang, Y | 1 |
| Lim, SG | 1 |
| Agarwal, K; Asselah, T; Berg, T; Bhandari, BR; Borgia, SM; Brainard, DM; Bräu, N; Davis, M; Dore, GJ; Dvory-Sobol, H; Feld, JJ; Foster, GR; Gane, EJ; Hyland, RH; Jacobson, IM; Lawitz, E; McHutchison, JG; Nahass, RG; Pearlman, B; Roberts, SK; Ruane, PJ; Shafran, SD; Stamm, LM; Stedman, CAM; Subramanian, GM; Svarovskaia, E; Thompson, AJ; Willems, BE; Workowski, KA; Zhu, Y | 1 |
| Agarwal, K; Aguilar, H; Asatryan, A; Dore, GJ; Felizarta, F; Gane, E; Gordon, SC; Hassanein, T; Kort, J; Kwo, PY; Lin, CW; Liu, R; Lovell, SS; Maliakkal, B; Mensa, FJ; Muir, AJ; Ng, TI; Overcash, JS; Poordad, F; Sulkowski, MS; Wang, S; Wyles, DL | 1 |
| Bowman, ML; Casey, L; Christensen, H; James, P; Kahr, WHA; Li, L; Lillicrap, D; Pluthero, FG; Robinson, KS; Tuttle, A | 1 |
| Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Quinson, AM; Strelkowa, N | 1 |
| An, SSA; Bagyinszky, E; Giau, VV; Kim, S; Park, J; Shim, K; Youn, YC | 1 |
| Iwasaki, A; Matsubara, T; Sato, T; Shiota, I; Suenaga, K; Sumimoto, S | 1 |
| Bansal, MB; Bourlière, M; Brainard, DM; Buggisch, P; Cooper, CL; Curry, MP; de Lédinghen, V; Dvory-Sobol, H; Flamm, SL; Gordon, SC; Huang, KC; Hyland, RH; Kowdley, KV; Landis, CS; Manns, MP; McHutchison, JG; Pianko, S; Ramji, A; Ravendhran, N; Reddy, KR; Schiff, ER; Stamm, LM; Strasser, SI; Subramanian, GM; Svarovskaia, E; Tong, M; Tran, TT; Verna, EC; Vierling, JM; Younes, ZH; Zeuzem, S; Zhang, J | 1 |
| Jacobson, IM; Voaklander, R | 1 |
| Bédard, AC; Collins, SK; Godin, É; Raymond, M | 1 |
| Asatryan, A; Campbell, A; Dutta, S; Lin, CW; Liu, W; Zhao, W | 1 |
| Arias, A; Barreiro, P; Benítez-Gutiérrez, L; Carrasco, I; de Mendoza, C; Peña, JM; Soriano, V | 1 |
| Byrne, HJ; Danish, MK; Frias, JM; Ryan, SM; Vozza, G | 1 |
| Asatryan, A; Campbell, A; Ding, B; Dutta, S; Kort, J; Lin, CW; Liu, W; Podsadecki, T; Wang, T; Zadeikis, N | 1 |
| Asatryan, A; Geoffroy, P; Kort, J; Kosloski, MP; Liu, W; Zhao, W | 1 |
| Aguilar, H; Felizarta, F; Forns, X; Ghalib, R; Hassanein, T; Hinrichsen, H; Horsmans, Y; Kort, JJ; Krishnan, P; Lee, SS; Lens, S; Lin, CW; Mensa, FJ; Morillas, R; Nelson, DR; Rincon, D; Valdes, J; Yu, Y; Zeuzem, S | 1 |
| Alves, K; Atarashi, T; Atsukawa, M; Burroughs, M; Chayama, K; Fu, B; Kato, K; Kumada, H; Naganuma, A; Nakamuta, M; Notsumata, K; Oberoi, RK; Osaki, Y; Pilot-Matias, TJ; Pugatch, D; Redman, R; Saito, S; Sato, K; Suzuki, F; Takaguchi, K; Toyoda, H; Watanabe, T | 1 |
| Agarwal, K; Alric, L; Felizarta, F; Hassanein, T; Kort, J; Krishnan, P; Kwo, PY; Lee, SS; Lin, CW; Liu, R; Lovell, SS; Maliakkal, B; Mensa, FJ; Pilot-Matias, T; Poordad, F; Wang, S; Weilert, F; Wyles, D | 1 |
| Lamb, YN | 1 |
| Alves, K; Atarashi, T; Burroughs, M; Chayama, K; Eguchi, Y; Karino, Y; Kato, K; Kawakami, Y; Krishnan, P; Kumada, H; Naganuma, A; Oberoi, RK; Pilot-Matias, TJ; Pugatch, DL; Redman, R; Sato, K; Seike, M; Suzuki, F; Takei, Y; Watanabe, T; Xie, W; Yoshiji, H | 1 |
| Agarwal, K; Aguilar, H; Asselah, T; Calinas, F; Colombo, M; de Ledinghen, V; Elkhashab, M; Hassanein, T; Hezode, C; Horsmans, Y; Kort, J; Kowdley, KV; Krishnan, P; Lin, CW; Liu, R; Mantry, PS; Marinho, RT; Mensa, FJ; Nevens, F; Ng, TI; Wang, S; Zadeikis, N | 1 |
| Deangeli, G; Di Monte, DA; Migdalska-Richards, A; Rusconi, R; Schapira, AHV; Spillantini, MG; Wegrzynowicz, M | 1 |
| Du, W; Gou, X; Hu, J; Liang, L; Liu, W; Zuo, K | 1 |
| Bräu, N; Brown, A; Collins, C; Colombo, M; Gane, E; Kosloski, M; Lawitz, E; Lei, Y; Leroy, V; Mensa, FJ; Moreno, C; Nelson, DR; Papatheodoridis, G; Persico, M; Pol, S; Pugatch, D; Yoshida, EM | 1 |
| Conforti, FL; Di Fini, F; La Bella, V; Lo Bello, M; Notaro, A; Spataro, R | 1 |
| Birnkrant, D; Chan-Tack, K; Naeger, LK; Qi, K; Struble, K | 1 |
| Brainard, DM; Cheng, G; Dvory-Sobol, H; Lawitz, E; Miller, MD; Mo, H; Stamm, LM; Taylor, JG; Yang, JC | 1 |
| Aschenbrenner, DS | 2 |
| Kottilil, S; O'Brien, TR; Pfeiffer, RM | 1 |
| Chahine, EB; Childs-Kean, LM; Kelley, D | 1 |
| Asatryan, A; Bernstein, DE; Buti, M; Felizarta, F; Fried, MW; Gallant, J; Gordon, SC; Hézode, C; Kopecky-Bromberg, S; Kort, J; Krishnan, P; Lei, Y; Lin, CW; Mensa, FJ; Ng, TI; Pianko, S; Pol, S; Poordad, F; Reindollar, RW; Shaw, D | 1 |
| Bourliere, M; Cooper, C; Flamm, S; Gordon, S; Hunt, S; Jacobson, I; Kowdley, K; Mann, MP; Reddy, KR; Stepanova, M; Younossi, I; Younossi, ZM; Zeuzem, S | 1 |
| Li, GF; Yu, G; Zhou, HH | 1 |
| Forns, X; Mensa, FJ | 1 |
| Beyer, J; Burroughs, M; Chayama, K; Collins, C; Dekhtyar, T; Fu, B; Irvin, M; Krishnan, P; Kumada, H; Pilot-Matias, T; Redman, R; Reisch, T; Schnell, G; Tripathi, R; Xie, W | 1 |
| Asselah, T; Foster, GR; Gane, EJ; Henry, L; Jacobson, IM; Lawitz, E; Pearlman, B; Racila, A; Roberts, SK; Stepanova, M; Thompson, AJ; Welzel, TM; Willems, BE; Younossi, I; Younossi, ZM | 1 |
| Besandre, R; Liu, HW | 1 |
| Hubbard, H; Lawitz, E | 1 |
| Kurt Yilmaz, N; Matthew, AN; Schiffer, CA | 1 |
| Collins, MG; Kort, J; Kosloski, MP; Liu, W; Marbury, TC; Mensa, F; Preston, RA; Pugatch, D; Zhao, W | 1 |
| Hussar, DA | 1 |
| Acker, T; Akintürk, H; Garvalov, BK; Gräf, S; Gulatz, L; Hahn, A; Jux, C; Mazhari, N; Rupp, S; Schänzer, A; Van Coster, R; Zengeler, D | 1 |
| Younossi, ZM | 1 |
| Danta, M; Sanagapalli, S | 1 |
| Asatryan, A; Asselah, T; Bourlière, M; Bruck, R; Chuang, WL; Dore, GJ; Feld, JJ; Felizarta, F; Flamm, S; Flisiak, R; Foster, GR; Fu, B; Fuster, F; Gane, E; Kaita, K; Kort, J; Kwo, P; Lin, CW; Liu, R; Mensa, FJ; Ng, TI; Paik, SW; Pilot-Matias, T; Pol, S; Poordad, F; Puoti, M; Roberts, SK; Ruane, PJ; Sepulveda-Arzola, G; Soto-Malave, R; Stedman, CA; Tam, E; Trinh, R; Vargas, HE; Vierling, J; Wang, S; Wedemeyer, H; Zeuzem, S | 1 |
| Huang, F; Rowland, L; Sabo, JP; Schultz, A; Trampisch, M; Voelk, C | 1 |
| Carrion, AF; Martin, P | 1 |
| Liu, W; Oberoi, RK; Sidhu, DS; Trinh, R; Viani, RM; Zhao, W | 1 |
| Debes, JD; Singh, D | 1 |
| Cavanaugh, J; French, JA; Mustoe, A | 1 |
| Deeks, ED; Heo, YA | 1 |
| Chang, TT; Dufour, JF; Foster, GR; Gane, E; Gordon, SC; Hezode, C; Lee, SS; Lovell, S; Marinho, R; Mensa, FJ; Moreno, C; Mutimer, D; Pilot-Matias, T; Pol, S; Puoti, M; Strasser, SI; Thuluvath, PJ; Wang, S; Zhang, Z | 1 |
| Forde, KA; Sawinski, D; Wyatt, CM | 1 |
| Abe-Chayama, H; Aikata, H; Chayama, K; Hayes, CN; Imamura, M; Ishida, Y; Makokha, GN; Miki, D; Ochi, H; Osawa, M; Tateno, C; Teraoka, Y; Tsuge, M; Uchida, T | 1 |
| Cory, TJ; Gong, Y; Kodidela, S; Kumar, S; Mu, Y | 1 |
| Agarwal, K; Angus, P; Brown, RS; Dumas, EO; Forns, X; Gane, E; Gulati, A; Hu, YB; Kao, JH; Krishnan, P; Kwo, PY; Liu, W; Mantry, PS; Mutimer, D; Porcalla, A; Reau, N; Reddy, KR; Rhee, S; Samanta, S; Shulman, NS; Tran, TT; Trinh, R | 1 |
| Amat, R; Bahri, M; Barceló-Coblijn, G; Campbell, M; Carobbio, S; Dias, AR; Gray, SL; Prieur, X; Relat, J; Rodriguez-Cuenca, S; Vidal-Puig, A | 1 |
| Chai, J; Deng, K; Diao, Q; Nie, M; Qi, M; Wang, H; Zhang, N; Zhao, J | 1 |
| Allmann, S; Bertiaux, E; Biran, M; Bouyssou, G; Bringaud, F; Crouzols, A; Dittrich-Domergue, F; Fouillen, L; Kiema, TR; Mazet, M; Millerioux, Y; Moreau, P; Plazolles, N; Rotureau, B; Thapa, C; Wierenga, RK | 1 |
| Abutaleb, A; Kottilil, S; Wilson, E | 1 |
| Waked, I | 1 |
| Bourlière, M; Brainard, DM; Curry, MP; Dvory-Sobol, H; Gordon, SC; Hyland, RH; Landis, CS; Manns, MP; McHutchison, JG; Ravendhran, N; Reddy, KR; Schiff, ER; Sepe, TE; Serfaty, L; Stamm, LM; Subramanian, GM; Thompson, AJ; Tran, TT; Zhang, J | 1 |
| Summers, BB | 1 |
| Bourliere, M; Gordon, SC; Manns, MP; Racila, A; Reddy, R; Schiff, E; Stepanova, M; Tran, T; Younossi, I; Younossi, ZM | 1 |
| Beyer, J; Collins, C; Dekhtyar, T; Irvin, M; Krishnan, P; Larsen, L; Mensa, FJ; Ng, TI; Pilot-Matias, T; Reisch, T; Schnell, G; Tripathi, R; Xie, W | 1 |
| Nehra, V; Rizza, SA; Temesgen, Z | 1 |
| Akuta, N; Arase, Y; Fujiyama, S; Hosaka, T; Ikeda, K; Kawamura, Y; Kobayashi, M; Kumada, H; Saitoh, S; Sezaki, H; Suzuki, F; Suzuki, Y | 1 |
| Bourliere, M; Brainard, DM; Camus, G; Cooper, CL; Doehle, BP; Dvory-Sobol, H; Flamm, SL; Gordon, SC; Hyland, RH; Kowdley, KV; Manns, MP; Martin, R; Mo, H; Reddy, KR; Roberts, SK; Sarrazin, C; Stamm, LM; Svarovskia, E; Zeuzem, S | 1 |
| Asatryan, A; Beyer, J; Campbell, A; Collins, C; Dekhtyar, T; Irvin, M; Kort, J; Krishnan, P; Lawitz, EJ; Lovell, S; Lu, L; Mensa, F; Ng, TI; Pilot-Matias, T; Reisch, T; Schnell, G; Tripathi, R; Yao, B | 1 |
| Kottilil, S; Mathur, P; Wilson, E | 1 |
| Beyer, J; Collins, C; Dekhtyar, T; Irvin, M; Krishnan, P; Lu, L; Ng, TI; Pilot-Matias, T; Reisch, T; Schnell, G; Tripathi, R; Xie, W | 1 |
| Hinds, AE; Pearlman, BL | 1 |
| Fabrizi, F; Messa, P | 1 |
| Aikata, H; Chayama, K; Fujino, H; Hayes, CN; Hiramatsu, A; Imamura, M; Kawaoka, T; Miki, D; Morio, K; Murakami, E; Nakahara, T; Ono, A; Osawa, M; Teraoka, Y; Tsuge, M; Uchida, T | 1 |
| Gane, E; Kort, J; Kosloski, MP; Lawitz, E; Liu, W; Marbury, TC; Mensa, FJ; Preston, RA; Pugatch, D; Wang, H | 1 |
| Erlich, DR; Grover, A | 1 |
| Abergel, A; Asselah, T; Gane, E; Lee, SS; Lim, SG; Mahomed, A; Mensa, FJ; Nguyen, K; Nguyen, T; Porcalla, A; Sasadeusz, J; Schnell, G; Wong, F; Yao, BB; Zadeikis, N; Zhang, Z | 1 |
| Agarwal, K; Asatryan, A; Flamm, S; Gane, E; Heo, J; Horsmans, Y; Kopecky-Bromberg, S; Krishnan, P; Kwo, PY; Lovell, SS; Mensa, FJ; Mutimer, D; Ng, TI; Rockstroh, J; Ruane, PJ; Ryder, SD; Trinh, R; Villa, E; Wang, S; Weiland, O; Welzel, TM; Wyles, DL; Xue, Z | 1 |
| Caroleo, B; Caroleo, MC; Cimellaro, A; Colangelo, L; De Sarro, G; Di Mizio, G; Gallelli, L; Perticone, M | 1 |
| Baba, M; Izumi, T; Kawagishi, N; Kimura, M; Maehara, O; Morikawa, K; Nakai, M; Nakamura, A; Natsuizaka, M; Ogawa, K; Ohara, M; Sakamoto, N; Shigesawa, T; Shimazaki, T; Sho, T; Suda, G; Suzuki, K; Umemura, M | 1 |
| Bondin, M; Cacoub, P; Fabrizi, F; Negro, F | 1 |
| Cenderello, G; Di Biagio, A; Taramasso, L | 1 |
| Liu, W; Lovell, S; Mensa, FJ; Pilot-Matias, T | 1 |
| Aghemo, A; Lleo, A; Plaz Torres, MC | 1 |
| Aguilar, H; Asatryan, A; Asselah, T; Baumgarten, A; Conway, B; Dore, GJ; Foster, GR; Grebely, J; Gschwantler, M; Hu, Y; Jackson, D; Mensa, FJ; Sherman, KE; Tomasiewicz, K; Wang, S | 1 |
| Chuang, WL; Crawford, DHG; Dokmeci, AK; Hamid, SS; Ibrahim, A; Jindal, A; Kanda, T; Kao, JH; Kumar, M; Lau, GKK; Lesmana, CRA; McCaughan, GW; Moriyama, M; Omata, M; Sarin, SK; Sharma, BC; Sollano, J; Wasim, J; Wei, L; Yokosuka, O; Yu, ML | 1 |
| Baba, M; Kawagishi, N; Kimura, M; Maehara, O; Morikawa, K; Nakai, M; Nakamura, A; Natsuizaka, M; Ogawa, K; Ohara, M; Sakamoto, N; Shigesawa, T; Shimazaki, T; Sho, T; Suda, G; Suzuki, K; Umemura, M | 1 |
| Bjornsti, MA; Blackburn, T; McGarity, S; Onuiri, JE; Placzek, WJ; Whitaker, RH; Wright, CM | 1 |
| Asatryan, A; Asselah, T; Foster, GR; Kopecky-Bromberg, S; Lei, Y; Mensa, FJ; Trinh, R; Zadeikis, N | 1 |
| Kubo, T; Nanmoku, K; Shimizu, T; Shinzato, T; Yagisawa, T | 1 |
| Imai, Y; Kouyama, JI; Mochida, S; Motoya, D; Naiki, K; Nakao, M; Nakayama, N; Sugawara, K; Tomiya, T; Tsuji, S; Uchida, Y; Uemura, H | 1 |
| Brainard, DM; Dvory-Sobol, H; Gane, EJ; Hyland, RH; Nyberg, L; Ruane, P; Shafran, S; Shao, J; Stamm, LM; Strasser, SI; Tran, T | 1 |
| Blouin, JL; Gerster, K; Guipponi, M; Lang-Muritano, M; Santoni, F; Schwitzgebel, VM; Stekelenburg, C | 1 |
| Althoff, CE; Bergfeld, L; Brakemeier, S; Budde, K; Duerr, M; Eckardt, KU; Glander, P; Halleck, F; Lehner, LJ; Marticorena Garcia, SR; Sack, I; Schrezenmeier, EV | 1 |
| Camus, G; Dvory-Sobol, H; Han, B; Hsieh, D; Lu, J; Martin, R; Mo, H; Parhy, B; Svarovskaia, ES | 1 |
| French, JA; Mehrotra, S; Murray, TF; Mustoe, AC; Pierce, ML | 1 |
| Balibrea, N; Franco, A; Gimeno, A; Kanter, J; Merino, E; Moreso, F; Perez Contreras, F; Rodriguez, M; Sancho, A | 1 |
| Cereb, N; Cho, L; Kaur, A; Lin, PY; Yang, KL | 1 |
| Brown, A; Dufour, JF; Gordon, SC; Mauss, S; Mensa, FJ; Pilot-Matias, T; Poordad, F; Rodrigues, L; Stoehr, A; Weiland, O; Weilert, F; Wyles, D; Yao, B; Zhang, Z | 1 |
| Abe, H; Aizawa, Y; Akahane, T; Atsukawa, M; Fukunishi, S; Genda, T; Hotta, N; Ikegami, T; Iwakiri, K; Kondo, C; Kumada, T; Michitaka, K; Nakamuta, M; Nozaki, A; Ogawa, C; Shima, T; Shimada, N; Tachi, Y; Takaguchi, K; Tanaka, Y; Toyoda, H; Tsubota, A; Tsuji, K; Uojima, H; Watanabe, T | 1 |
| Kiser, JJ | 1 |
| Asatryan, A; Elkhashab, M; Gane, E; Greenbloom, S; Lin, CW; Liu, W; Mensa, FJ; Mulkay, JP; Nguyen, T; Pilot-Matias, T; Poordad, F; Porcalla, A; Setze, C; Stedman, C; Tran, A; Valdes, J; Wang, S; Wörns, MA; Yu, Y; Zadeikis, N | 1 |
| Bukh, J; Dietz, J; Fahnøe, U; Filskov, J; Fourati, S; Ghanem, L; Gottwein, JM; Humes, D; Jensen, SB; Krarup, H; Pawlotsky, JM; Pedersen, MS; Pham, LV; Pihl, AF; Ramirez, S; Sarrazin, C; Schønning, K; Serre, SBN; Sølund, CS; Tang, Q; Weis, N | 1 |
| Back, D; Belperio, P; Bondin, M; Crown, E; Marra, F; Mensa, FJ; Negro, F; Park, C; Pinsky, B; Talal, AH; Zhang, Z | 1 |
| Idrees, H; Mujtaba, G; Naz, S; Ramzan, M; Sobreira, N; Witmer, PD | 1 |
| Aghemo, A; Parigi, TL; Torres, MCP | 1 |
| Angulo-Diaz, V; Lim, JK; Mandimika, C; Maughan, A; Ogbuagu, O; Sadigh, K; Villanueva, M | 1 |
| Hinds, A; Pearlman, B; Perrys, M | 1 |
| Appleby, T; Barauskas, O; Chan, K; Cheng, G; Jin, D; Karki, KK; Katana, A; Kato, D; Kobayashi, T; Link, JO; Martinez, R; Ramey, K; Sangi, M; Schrier, A; Schultz, BE; Siegel, D; Taylor, JG; Tran, CV; Villaseñor, AG; Vivian, R; Wang, K; Wang, Y; Yang, CY; Yang, ZY; Zablocki, J; Zipfel, S | 1 |
| Koike, K; Tanaka, Y; Tateishi, R | 1 |
| Alajmi, MF; Hassan, I; Hussain, A; Naqvi, AAT; Rehman, T | 1 |
| Chua, J; Comstock, E; Covert, E; Emmanuel, B; Hoffmann, J; Husson, J; Kattakuzhy, S; Kottilil, S; Masur, H; Mathur, P; Price, A; Rosenthal, E; Tang, L; Wilson, E | 1 |
| Aglitti, A; Brancaccio, G; Caroleo, B; Claar, E; Coppola, C; Coppola, N; Cozzolongo, R; Di Costanzo, GG; Federico, A; Fontanella, L; Gatti, P; Gentile, I; Longo, A; Masarone, M; Messina, V; Milella, M; Morisco, F; Persico, M; Pierri, P; Rosato, V; Serviddio, G; Sogari, F; Surace, LA; Termite, AP; Terrenato, I; Tundo, P | 1 |
| Akuta, N; Arase, Y; Fujiyama, S; Hosaka, T; Ikeda, K; Kasuya, K; Kawamura, Y; Kobayashi, M; Kumada, H; Saitoh, S; Sano, T; Sezaki, H; Suzuki, F; Suzuki, Y | 1 |
| Cooke, G; Fawsitt, CG; Vickerman, P; Welton, NJ | 1 |
| Antonio Carrión, J; Arenas, J; Arencibia, A; Badia, E; Bernal, V; Buti, M; Cachero, A; Carmona, I; Conde, I; Delgado, M; Diago, M; Esteban, R; Fernández, I; Fernández-Bermejo, M; Fernández-Rodríguez, C; Figueruela, B; García-Samaniego, J; Gea, F; González-Santiago, JM; Hernández-Guerra, M; Iñarrairaegui, M; Lens, S; Llaneras, J; Llerena, S; Luis Calleja, J; María Morillas, R; Mariño, Z; Montoliu, S; Pascasio, JM; Riveiro-Barciela, M; Rosales, JM; Torras, X; Turnes, J | 1 |
| Arai, T; Asai, A; Asano, T; Atsukawa, M; Fukunishi, S; Hayama, K; Hiraoka, A; Iio, E; Ikeda, H; Ikegami, T; Itokawa, N; Iwakiri, K; Kato, K; Kikuchi, K; Kondo, C; Kumada, T; Matsumoto, N; Matsumoto, Y; Mikami, S; Moriya, A; Nakamuta, M; Nozaki, A; Ogawa, C; Oikawa, T; Okubo, H; Okuse, C; Shimada, N; Tachi, Y; Tada, T; Takaguchi, K; Tanaka, Y; Tani, J; Toyoda, H; Tsubota, A; Tsuruoka, S; Tsutsui, A; Uojima, H; Watanabe, T; Yamashita, N | 1 |
| Chen, CC; Chen, CH; Chen, DS; Chiu, MC; Fang, YJ; Hsu, SJ; Kao, JH; Kuo, CC; Lee, JY; Yang, TH; Yu, JJ | 1 |
| Fukuchi, T; Kakizaki, S; Naganuma, A; Namikawa, M; Ohnishi, H; Okamoto, H; Sato, K; Uraoka, T | 1 |
| Mesgari-Abbasi, M; Mirzakhani, N; Vahdatpour, T; Valizadeh, H | 1 |
| Burroughs, M; Chayama, K; Eckert, D; Kato, K; Kumada, H; Lin, CW; Liu, W; Mensing, S; Oberoi, RK; Suleiman, AA | 1 |
| Cotter, TG; Jensen, DM | 1 |
| Aghemo, A; Asselah, T; Bräu, N; Brown, A; Chen, YJ; Conway, B; Grebely, J; Kleine, H; Lawitz, E; Lei, Y; Mensa, FJ; Negro, F; Pugatch, D; Puoti, M; Welzel, TM | 1 |
| Chaparro, M; García-Buey, L; Rojo, E | 1 |
| Chen, B; Chen, K; Li, Y; Shi, H; Wang, Q; Xiao, J; Zhou, Q; Zhou, X | 1 |
| Bourliere, M | 1 |
| Ankoma-Sey, V; Bondin, M; Dos Santos, AGP; Elkhashab, M; Fontana, RJ; Lens, S; McPherson, S; Porcalla, A; Trinh, R; Xue, Z; Zeuzem, S | 1 |
| Agarwal, K; Dore, GJ; Dos Santos, AGP; Feld, JJ; Gane, E; Hezode, C; Kho, D; Klein, M; Lacombe, K; Marks, P; Martinello, M; Matthews, GV; Mercade, GE; Muir, AJ; Müllhaupt, B; Petoumenos, K; Schultz, M; Tatsch, F; Thompson, A; Wedemeyer, H | 1 |
| Abergel, A; Aguilar, H; Brown, RS; Burroughs, M; Buti, M; Carrion, BR; Chuang, WL; Chulanov, V; Cohen, E; Felizarta, F; Horváth, G; Lin, CW; Lovell, SS; Mensa, FJ; Rodrigues, L; Rodriguez-Perez, F; Schnell, G; Trinh, R; Urbánek, P; Wang, S; Zha, J; Zuckerman, E | 1 |
| Ferenci, P | 1 |
| Chen, DS; Chen, PJ; Hsieh, SM; Hung, CC; Kao, JH; Liu, CH; Liu, CJ; Su, TH; Sun, HY; Tseng, TC | 1 |
| Chayama, K; Gonzalez, YS; Kawaguchi, I; Kumada, H; Mitchell, D; Virabhak, S; Yuen, C | 1 |
| Aikata, H; Chayama, K; Hiramatsu, A; Imamura, M; Kawaoka, T; Morio, K; Murakami, E; Nakahara, T; Ohya, K; Tsuge, M; Yamauchi, M | 1 |
| Abunimeh, M; Aglitti, A; Bruchfeld, A; Flisiak, R; Jalundhwala, YJ; Kaskas, M; Lawitz, E; Mensa, FJ; Park, JY; Persico, M; Porcalla, A; Schnell, G; Sise, ME; Wörns, MA; Xue, Z; Zamor, PJ | 1 |
| Ali, A; Henes, M; Hou, S; Kosovrasti, K; Kurt Yilmaz, N; Leidner, F; Schiffer, CA; Timm, J | 1 |
| Anderson, M; Caro, L; Chung, C; Fandozzi, C; Fraser, I; Gao, W; Howell, B; Mangin, E; Maxwell, J; Miltenburg, AMM; Popa, S; Railkar, R; Shire, NJ; Stoch, SA; Talal, AH; Van Dyck, K; Webber, AL; Wenning, L | 1 |
| Chung, RT; Holmes, JA | 1 |
| Ashraf, A; Kumar, R; Maitra, S; Singh, AD; Singh, N; Tyagi, P | 1 |
| Abe, H; Akahane, T; Asano, T; Atsukawa, M; Chuma, M; Fujioka, S; Fukunishi, S; Genda, T; Hiraoka, A; Iio, E; Ikeda, H; Ikegami, T; Ishikawa, T; Iwakiri, K; Kumada, T; Masaki, T; Michitaka, K; Mikami, S; Morishita, A; Moriya, A; Nakamuta, M; Nozaki, A; Ogawa, C; Okanoue, T; Okubo, H; Okubo, T; Shima, T; Shimada, N; Tachi, Y; Takaguchi, K; Tanaka, Y; Tani, J; Toyoda, H; Tsubota, A; Tsuji, K; Tsutsui, A; Uojima, H; Watanabe, T; Yamashita, N; Yasuda, S | 1 |
| Chen, DS; Chen, PJ; Kao, JH; Lin, WT; Liu, CH; Liu, CJ; Peng, CY; Su, TH; Tseng, TC; Yang, SS | 1 |
| Kakizaki, S; Kizawa, K; Kosone, T; Marubashi, K; Sato, K; Takagi, H; Takakusagi, S; Uraoka, T; Yokoyama, Y | 1 |
| Kwo, PY; Kwong, AJ | 1 |
| Kumar, R; Singh, AD | 1 |
| Kamal, R; Li, Q; Shen, H; Wang, Q; Yu, X; Zhao, ZK | 1 |
| Angelico, M; Aragri, M; Carioti, L; Ceccherini-Silberstein, F; Di Maio, VC; Lenci, I; Milana, M; Perno, CF; Svicher, V | 1 |
| Hasegawa, K; Kinoshita, A; Kobayashi, Y; Koike, K; Mizuno, Y; Nakata, R; Ogata, I; Shiraishi, K; Yamada, N; Yasuda, K; Yoshida, H | 1 |
| Bacon, B; Curry, MP; Dylla, DE; Flamm, SL; Kort, J; Marx, SE; Strezewski, J; Tsai, N; Wick, N | 1 |
| Chang, TS; Chen, CH; Chen, MY; Chen, WM; Chiu, WN; Hu, JH; Hu, TH; Hung, CH; Lu, CK; Lu, SN; Tung, SY; Wei, KL | 1 |
| Maasoumy, B; Ohlendorf, V | 1 |
| Khalil, H; Kim, NG; Kullar, R; Saab, S | 1 |
| Bernhard, B; Stickel, F | 1 |
| AlAjmi, MF; Anwar, S; Hassan, MI; Hussain, A; Islam, A; Mohammad, T; Rehman, MT; Shamsi, A | 1 |
| Fargnoli, A; Gidea, CG; Jacobson, I; Kon, Z; Lewis, T; Lonze, B; Moazami, N; Pavone, J; Qian, Y; Rao, S; Reyentovich, A; Saraon, T; Smith, D | 1 |
| Abergel, A; Asselah, T; Fredrick, LM; Gane, E; George, C; Hung Le, M; Kowdley, KV; Kwo, PY; Lee, SS; Mensa, F; Nguyen, K; Nguyen, T; Pham, TT; Poordad, F; Schnell, G; Spearman, CW; Wong, F; Yao, BB | 1 |
| Da, BL; Dieterich, D; Kushner, T; Lourdusamy, V; Saberi, B | 1 |
| Chen, DS; Chen, PJ; Kao, JH; Liu, CH; Liu, CJ; Su, TH | 1 |
| Batskikh, SN; Burnevich, EZ; Chulanov, VP; Gusev, DA; Kizlo, SN; Klimova, EA; Krasavina, EN; Mamonova, NA; Samsonov, MY; Tarkhova, EP; Yushchuk, ND; Znoyko, OO | 1 |
| Caruntu, F; Cohen, S; de Ledinghen, V; Dillon, JF; Dylla, DE; Fredrick, LM; Gschwantler, M; Gutierrez, JA; Muir, AJ; Nevens, F; Pires Dos Santos, AG; Puoti, M; Rodrigues, L; Sigal, S; Slim, J; Zuckerman, E | 1 |
| Liu, W; Mensa, F; Oberoi, RK; Rosebraugh, M; Wang, H; Zhao, W | 1 |
| Angel, L; Gidea, C; Kon, Z; Lesko, M; Lewis, TC; Moazami, N; Pavone, J; Reyentovich, A; Smith, DE; Sureau, K | 1 |
| Alami, NN; Asatryan, A; Burroughs, M; Fredrick, LM; Heo, J; Hou, J; Jia, J; Kalluri, HV; Kim, YJ; Krishnan, P; Lim, SG; Liu, W; Lu, W; Mobashery, N; Tripathi, R; Wang, G; Wei, L; Xie, Q; Xie, W; Zhang, M | 1 |
| Barclay, ST; Belperio, PS; Bondin, M; Flamm, S; Lampertico, P; Lohmann, K; Marra, F; Marx, S; Mauss, S; Persico, M; Wedemeyer, H; Zhang, Z | 1 |
| Aragri, M; Arenas Ruiz Tapiador, JI; Cabezas, J; Callegaro, A; Ceccherini-Silberstein, F; Coppola, N; de Salazar, A; di Maio, VC; Dietz, J; Garcia Del Toro, M; García, F; Graf, C; Jimenez, M; Macias Rodriguez, MA; Micheli, V; Müllhaupt, B; Paolucci, S; Pascasio Acevedo, JM; Puoti, M; Rosales Zabal, JM; Sarrazin, C; Stauber, RE; Téllez, F; Vermehren, J | 1 |
| Chen, YY; Chou, KC; Hsu, YC; Huang, SP; Liu, IL; Su, PY; Wu, SS; Yang, CW; Yen, HH; Zeng, YH | 1 |
| Rodriguez-Reyes, M; Ruiz-Boy, S; Sotoca-Momblona, JM | 1 |
| Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y | 1 |
| Cho, M; Heo, J; Hong, YM; Kim, DU; Kim, GH; Kim, HH; Park, SG; Park, YJ; Song, GA; Woo, HY; Yoon, KT | 1 |
| Cappelli, C; Delbarba, A; Di Lodovico, E; Facchetti, F; Facondo, P; Ferlin, A; Fisogni, S; Izzi, C; Maffezzoni, F; Pezzaioli, LC; Scolari, F | 1 |
| Alloway, RR; Aull, MJ; Barnaba, B; Belshe, DS; Brown, RS; Chung, RT; Desai, NM; Doshi, M; Durand, CM; Elias, N; Fernando, M; Fontana, RJ; Friedewald, JJ; Goldberg, DS; Gustafson, JL; Kort, JJ; Landis, JR; Levitsky, J; Norman, SP; Phillips, CC; Prenner, S; Reese, PP; Rike-Shields, A; Schaubel, DE; Sherman, KE; Sise, ME; Sultan, ST; Williams, WW; Woodle, ES | 1 |
| Chen, CH; Hsu, CS; Hsu, YC; Hui, YT; Kan, YM; Li, MKK; Liu, CH; Liu, KSH; Tsai, MC; Wong, GLH; Yap, DYH; Yu, ML; Yuen, MF | 1 |
| Ahlenstiel, G; Bowden, S; Dore, GJ; Douglas, M; Doyle, J; Farrell, G; Fisher, L; George, J; Haque, M; Hazeldine, S; Hellard, M; Levy, M; MacQuillan, G; McGarity, B; New, K; O'Beirne, J; O'Keefe, J; Papaluca, T; Prewett, E; Roberts, SK; Sawhney, R; Sievert, W; Sinclair, M; Sood, S; Stoove, M; Strasser, SI; Stuart, KA; Thomas, J; Thompson, AJ; Tse, E; Valaydon, Z; Valiozis, I; Wade, AJ; Weltman, M; Wigg, A; Wilson, M; Woodward, A | 1 |
| Cornberg, M; Deterding, K; Jung, MC; Klinker, H; Manns, MP; Sarrazin, C; Schulze Zur Wiesch, J; Serfert, Y; Simon, KG; Stoehr, A; Teuber, G; Vermehren, J; Wedemeyer, H; Zeuzem, S | 1 |
| Berg, T; Heyne, R; John, C; Klinker, H; Naumann, U; Niederau, C; Serfert, Y; Stein, K; Stoehr, A; Teuber, G; Wiegand, J; Zeuzem, S | 1 |
| Jiang, X; Xu, Y; Zhang, Y; Zhao, Y | 1 |
| Dronamraju, D; Kwo, P | 1 |
| Arii, S; Denda, M; Komiya, C; Kusumoto, K; Okuhira, K; Otaka, A; Shigenaga, A; Ueda, M | 1 |
| Govindarajan, R; Singh, S | 1 |
| Hernandez, C; Hezode, C; Mangia, A; Turnes, J | 1 |
| Singh, AD | 1 |
| Berak, H; Białkowska-Warzecha, J; Buczyńska, I; Citko, J; Deroń, Z; Dobracka, B; Dybowska, D; Flisiak, R; Halota, W; Horban, A; Janczewska, E; Jaroszewicz, J; Klapaczyński, J; Krygier, R; Laurans, Ł; Lorenc, B; Mazur, W; Pabjan, P; Pawłowska, M; Piekarska, A; Simon, K; Sitko, M; Sobala-Szczygieł, B; Socha, Ł; Tomasiewicz, K; Tronina, O; Tudrujek-Zdunek, M; Zarębska-Michaluk, D; Łapiński, TW | 1 |
| Crehuá Gaudiza, E; Quintero García, D; Sebastián Cuevas, FJ | 1 |
| Babudieri, S; Barbarini, G; Dell'Isola, S; Fiore, V; Madeddu, G; Marri, D; Pontali, E; Prestileo, T; Ranieri, R; Sotgiu, G; Starnini, G | 1 |
| Biliotti, E; Cruciata, A; Mezzaroma, I; Milito, C; Rivano Capparuccia, M; Spaziante, M; Taliani, G; Volpicelli, L | 1 |
| Chen, HW; Hsieh, CB; Hsieh, TY; Lin, JC | 1 |
| Akay, A; Braukmann, F; Helm, M; Hendrick, AG; Jordan, D; Kotter, A; Legrand, C; Lyko, F; Miska, EA; Navarro, IC; Price, J; Tuorto, F | 1 |
| Kao, JH; Yu, ML | 1 |
| Feng, Q; Jiang, J; Lukman, M; Ruiz-Carrillo, D; Zhang, Y; Zhao, Y; Zhou, X | 1 |
| Boonma, T; Darai, N; Nunthaboot, N; Nutho, B; Rungrotmongkol, T | 1 |
| Batyuk, A; Broweleit, J; Broweleit, R; Castillo-Orellana, C; Chiang, A; Garcia, AA; Gati, C; Horikoshi, N; Hwang, S; Jabbarpour, F; Matsui, T; Mochly-Rosen, D; Raub, AG; Vöhringer-Martinez, E; Wakatsuki, S; Xiang, X | 1 |
| Aksentijević, D; Bridges, HR; Burger, N; Grba, DN; Hirst, J; James, AM; Krieg, T; Kula-Alwar, D; Mottahedin, A; Murphy, MP; Prag, HA; Viscomi, C; Yin, Z | 1 |
| Chang, JF; Gan, ZX; Liu, KN; Liu, YZ; Sun, F; Sun, J; Yang, XM; Zhang, L; Zhang, W | 1 |
| Clerc, O; Magenta, L; Müllhaupt, B; Negro, F; Ruckstuhl, L; Semela, D; Semmo, N; Torgler, R | 1 |
| Bai, Y; Feng, Y; Fu, L; Gao, GF; Liao, H; Qi, J; Shi, Y; Song, H; Tan, W; Ye, F | 1 |
| Buonomo, AR; Cattaneo, L; Coppola, C; Coppola, N; De Pascalis, S; Gentile, I; Martini, S; Mercinelli, S; Messina, V; Nerilli, M; Pinchera, B; Scotto, R; Staiano, L; Stanzione, M; Stornaiuolo, G | 1 |
| Erren, P; König, B; Lohmann, K; Mauss, S; Naumann, U; Rieke, A; Stoehr, A; Wedemeyer, H; Zimmermann, T | 1 |
| Hara, T; Iwai, N; Kagawa, K; Komaki, T; Nagata, A; Ohara, T; Oka, K; Okuda, T; Sakagami, J; Sakai, H; Taniguchi, M; Tsuji, T | 1 |
| Hu, Y; Hurst, B; Ma, C; Szeto, T; Tarbet, B; Wang, J | 1 |
| Chan, C; Kulik, L; Martin, MT; Patel, S | 1 |
| Booth, J; Borgia, SM; Conway, B; Cooper, C; Feld, JJ; Lee, S; Lilly, LB; Morales, H; Onofrio, FQ; Ramji, A; Sattar, I; Vachon, ML; Wong, A | 1 |
| Buti, M; Campos, C; Cañizares, A; Carrión, JA; Castro-Iglesias, A; Costa, JG; Esteban, JI; Garcia-Cehic, D; Gregori, J; Macenlle, R; Pamplona, J; Quer, J; Rando, A; Rodriguez-Frias, F; Tabernero, D | 1 |
| Abohashrh, M; Ahmad, I; Alam, MM; Baig, MH; Dong, JJ; Sharma, T | 1 |
| Dietz, J; Sarrazin, C | 1 |
| Ebata, K; Hirata, K; Katagiri, M; Nakajima, S; Ozasa, M; Sakamoto, N; Sasaki, T; Suda, G; Takahash, S; Takano, M; Tsukamoto, S; Umemura, M | 1 |
| Beckman, JS; Glaskin, R; Hare, M; Klein, C; Oppenheimer, D; Schwarzer, C; Shaw, JB; Stafford, G; Sturgeon, D; Vasil'ev, Y; Voinov, VG; Wu, S | 1 |
| Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Strelkowa, N | 1 |
| Berg, T; Bondin, M; Cornberg, M; Klinker, H; Koenig, B; Lohmann, K; Naumann, U; Rössle, M; Zeuzem, S | 1 |
| Hazenkamp, M; Kluttig, M; Mayer, S; Ochs, D | 1 |
| Bourlière, M; Meszaros, M; Ouzan, D; Pageaux, GP; Tran, A; Truchi, R | 1 |
| Bondin, M; Brown, A; Burroughs, M; Chayama, K; Dylla, DE; Emmett, A; Feld, JJ; Forns, X; Gordon, SC; Heo, J; Hou, J; Jacobson, IM; Lampertico, P; Marcinak, J; Pol, S; Tatsch, F; Zhang, Z | 1 |
| Enomoto, M; Fujii, H; Hai, H; Kawada, N; Kozuka, R; Nonomura, A; Tamori, A; Uchida-Kobayashi, S | 1 |
| Adachi, T; Akashi, H; Akutsu, N; Ban, T; Hirano, T; Ishigami, K; Isshiki, H; Kaneto, H; Matsui, T; Nakachi, K; Nakahara, S; Nakase, H; Numata, Y; Sasaki, S; Takagi, H; Tanaka, K; Tsujisaki, M; Wagatsuma, K; Yamamoto, I; Yamaoka, S; Yawata, A; Yonezawa, K | 1 |
| Alami, NN; Asatryan, A; Bae, SH; Cho, M; Crown, ED; Fredrick, LM; Han, KH; Heo, J; Jeong, SH; Kim, DH; Kim, JH; Kim, YJ; Lee, JW; Lee, YJ; Lim, YS; Paik, SW; Yoon, KT | 1 |
| Andrade, RJ; Calleja, JL; Calvo, M; Delgado, MB; Frias, YN; Gálvez-Fernández, RM; Gómez, J; López, MA; Manzano, ML; Molina, E; Olveira, A; París, S; Rincón, D; Rosales, JM; Salmerón, FJ; Santos de Lamadrid, R; Turnes, J; Vallejo-Senra, N | 1 |
| Bukh, J; Christensen, PB; Fahnøe, U; Madsen, LW; Pedersen, MS; Øvrehus, A | 1 |
| Bassani, D; Bolcato, G; Moro, S; Pavan, M; Sturlese, M | 1 |
| Ichijo, T; Joshita, S; Kawakami, F; Kobayashi, H; Nakazawa, H; Sugiura, A; Umemura, T; Wakabayashi, SI; Yamashita, Y; Yamazaki, T | 1 |
| Aalikhani, M; Alikhani, M; Bazi, Z; Oladnabi, M; Shamsabadi, F | 1 |
| Ahmed, S; Ajaimy, M; Campbell, A; Graham, JA; Jorde, UP; Nnani, DU; Patel, SR; Saeed, O | 1 |
| Ekanayake, KB; George, J; Jackson, C; Mahawaththa, MC; Morewood, R; Nitsche, C; Otting, G; Sasi, VM; Shuttleworth, L; Ullrich, S; Whitefield, C; Zhang, X | 1 |
| Barclay, ST; Burroughs, M; Calleja, JL; de Ledinghen, V; Dylla, DE; Gane, E; Gutierrez, JA; Rizzardini, G; Shiffman, ML; Xue, Z | 1 |
| Brown, A; Colombo, M; Crown, E; Dillon, JF; Dylla, DE; Feld, JJ; Ghalib, R; Hu, Y; Jacobson, IM; Lawitz, E; Lovell, SS; Luetkemeyer, AF; Moreno, C; Mutimer, D; Nelson, DR; Papatheodoridis, G; Rockstroh, JK; Skoien, R; Zamor, PJ | 1 |
| Ramos-Guzmán, CA; Ruiz-Pernía, JJ; Tuñón, I | 1 |
| Ahmad, B; Ain, QU; Batool, M; Choi, S; Kim, MS | 1 |
| Flamm, SL; Martin, MT; Patel, S | 1 |
| Macchiagodena, M; Pagliai, M; Procacci, P | 1 |
| Kakizaki, S; Kanayama, Y; Ohnishi, H; Okamoto, H; Sato, K; Suga, T; Tojima, H; Uehara, D; Uraoka, T; Yamazaki, Y; Yanagisawa, K | 1 |
| Beier, C; Cornberg, M; Kordecki, N; Maasoumy, B; Ohlendorf, V; Sandmann, L; Tergast, TL; Wedemeyer, H | 1 |
| Feng, BL; Li, JM; Luo, JW; Naidoo, N; Wang, P; Wu, G; Xie, YX; Zhou, HJ | 1 |
| Duan, Y; Fang, C; Feng, L; Ma, D; Peng, C; Rao, Z; Shao, M; Wang, H; Yang, H; Yang, K; Yang, X; Zhang, L; Zhang, Q; Zhang, R; Zhao, J; Zhao, X; Zhao, Y; Zhu, Y | 1 |
| Karrenbrock, M; Macchiagodena, M; Pagliai, M; Procacci, P | 1 |
| Allerton, CMN; Anderson, AS; Aschenbrenner, L; Avery, M; Berritt, S; Boras, B; Cardin, RD; Carlo, A; Coffman, KJ; Dantonio, A; Di, L; Eng, H; Ferre, R; Gajiwala, KS; Gibson, SA; Greasley, SE; Hurst, BL; Kadar, EP; Kalgutkar, AS; Lee, J; Lee, JC; Liu, W; Mason, SW; Noell, S; Novak, JJ; Obach, RS; Ogilvie, K; Owen, DR; Patel, NC; Pettersson, M; Rai, DK; Reese, MR; Sammons, MF; Sathish, JG; Singh, RSP; Steppan, CM; Stewart, AE; Tuttle, JB; Updyke, L; Verhoest, PR; Wei, L; Yang, Q; Zhu, Y | 1 |
| Abbas, SN; Bhatti, S; Mahmood, N; Nasir, SB; Shahid, S | 1 |
| Couzin-Frankel, J | 1 |
| Bair, MJ; Chang, CC; Chang, TS; Chen, CT; Chen, CY; Chen, GY; Cheng, CY; Cheng, PN; Chong, LW; Chuang, WL; Dai, CY; Hsieh, TY; Hu, JT; Huang, CF; Huang, CS; Huang, CW; Huang, JF; Huang, YH; Hung, CH; Kao, CN; Kao, JH; Kuo, HT; Lee, MH; Lee, PL; Lee, TH; Lin, CL; Lin, HC; Liu, CJ; Lo, CC; Mo, LR; Peng, CY; Su, WW; Tai, CM; Tsai, PC; Tseng, KC; Wang, CC; Wang, SJ; Wu, WC; Yang, CC; Yang, SS; Yeh, ML; Yu, ML | 1 |
| Hachisu, Y; Hatanaka, T; Hazama, Y; Kaburagi, T; Kakizaki, S; Kashiwabara, K; Murata, K; Naganuma, A; Nagashima, S; Nakano, S; Nishizawa, T; Okamoto, H; Saito, N; Takahashi, M; Tanaka, Y; Uraoka, T; Yamazaki, Y; Yoshida, S; Yoshinaga, T | 1 |
| Wang, Z; Yang, L | 1 |
| Parums, DV | 2 |
| Davies, GW; Heskin, J; Jones, R; Moore, LSP; Mughal, N; Pallett, SJC; Rayment, M | 1 |
| Borio, LL; Bright, RA; Emanuel, EJ | 1 |
| Drożdżal, S; Ghavami, S; Kotfis, K; Lechowicz, K; Lorzadeh, S; Machaj, F; Przybyciński, J; Rosik, J; Szostak, B; Łos, MJ | 1 |
| Fetta, S; Kontoghiorghe, CN; Kontoghiorghes, GJ | 1 |
| Del Rio, C; Gandhi, RT; Malani, PN | 1 |
| Fishbane, S; Hirsch, JS; Nair, V | 1 |
| Li, J; Liu, J; Ma, HX; Wang, CY; Wen, J | 1 |
| Misra, A; Singh, A; Singh, AK; Singh, R | 1 |
| Kozlov, M | 1 |
| André, E; Chiu, W; De Jonghe, S; Jochmans, D; Leyssen, P; Maes, P; Neyts, J; Raymenants, J; Slechten, B; Vangeel, L | 1 |
| Alexander, G; Alric, L; Busch, MP; Carrington, M; Chung, RT; Cox, AL; Cramp, ME; Donfield, SM; Douillard, V; Duggal, P; Edlin, BR; Goedert, JJ; Gourraud, PA; Grifoni, A; Johnson, EO; Khakoo, SI; Kim, AY; Kirk, GD; Kral, AH; Lauer, GM; Mangia, A; Mehta, SH; Murphy, EL; Piazzolla, V; Price, JC; Rosen, HR; Sette, A; Thio, CL; Thomas, DL; Valencia, A; Vergara, C; Vince, N; Wojcik, GL | 1 |
| Bowman, CJ; Campion, SN; Cappon, GD; Catlin, NR; Cheung, JR; Nowland, WS; Sathish, JG; Stethem, CM; Updyke, L | 1 |
| Bajaj, SS; Stanford, FC | 1 |
| Bansal, S; Giacomet, V; Hsueh, CH; Indolfi, G; Iorio, R; Kelly, D; Kersey, K; Mangia, A; Mania, A; Nebbia, G; Parhy, B; Pawlowska, M; Sang Yue, M; Shao, J; Szenborn, L | 1 |
| Lee, TC; McDonald, EG | 1 |
| Chen, C; Cheng, Y; Feng, Z; Mao, Q; Tang, J; Wang, C; Wang, M; Wen, W; Wu, Q; Zhang, X; Zhou, M; Zhou, X | 1 |
| Hidaka, Y; Inadome, A; Kaba, A; Kashima, M; Miyata, A; Takekuma, Y; Toyoda, M; Yamanaga, S; Yokomizo, H | 1 |
| Martin, MT; Naveed, A; Waring, N | 1 |
| Boras, B; Dantonio, AL; Di, L; Eng, H; Kadar, EP; Kalgutkar, AS; Kimoto, E; Lin, J; Novak, JJ; Obach, RS; Patel, NC; Singh, RSP; Walker, GS | 1 |
| Abdelnabi, R; Augustijns, P; Chatelain, E; De Jonghe, S; Escudié, F; Foo, CS; Hoglund, RM; Jochmans, D; Mols, R; Mowbray, CE; Neyts, J; Scandale, I; Sjö, P; Tarning, J; Vangeel, L; Wattanakul, T; Weynand, B | 1 |
| Abreu, P; Baniecki, M; Bao, W; Damle, B; Gardner, A; Hammond, J; Hendrick, VM; Leister-Tebbe, H; Pypstra, R; Rusnak, JM; Simón-Campos, A; Wisemandle, W | 1 |
| Baden, LR; Morrissey, S; Rubin, EJ | 1 |
| Ekanayake, KB; Nitsche, C; Otting, G; Ullrich, S | 1 |
| Iglesias, C; Reina, J | 1 |
| Ali, A; Chan, ET; Hedger, AK; Henes, M; Kosovrasti, K; Kurt Yilmaz, N; Matthew, AN; Nageswara Rao, D; Schiffer, CA; Timm, J; Vo, SV; Zephyr, J | 1 |
| Usher, AD | 1 |
| Agarwal, K; Burroughs, M; Felizarta, F; Gane, E; Hassanein, T; Krishnan, P; Nevens, F; Overcash, JS; Poordad, F; Shaw, D; Topp, A; Waters, M; Yao, BB | 1 |
| Ledford, H | 1 |
| Camus, G; Grant, PM; Gupta, N; Kabihizi, J; Kateera, F; Makuza, JD; Manirambona, L; Mukabatsinda, C; Murangwa, A; Musabeyezu, E; Muvunyi, CM; Nsanzimana, S; Serumondo, J; Shumbusho, F | 1 |
| Brown, RS; Chen, JK; Hedvat, J; Jennings, DL; Kovac, DB; Lange, NW; Pereira, MR; Salerno, DM; Scheffert, J; Shertel, T | 1 |
| Almond, LM; Beringer, PM; Chung, PS; Hong, E; Rao, AP | 1 |
| Foerster, KI; Haefeli, WE; Mikus, G; Said, A; Schulz, M; Terstegen, T; Vogt, C | 1 |
| Christensen, PB; Dröse, S; Hansen, JF; Holm, DK; Madsen, LW; Røge, BT; Øvrehus, A | 1 |
| Ledford, H; Maxmen, A | 1 |
| Allen, R; Anderson, AS; Bergman, A; Binks, M; Chan, PL; Clark, F; Hackman, F; Kadar, EP; Menon, S; Nucci, G; Pawlak, S; Rao, R; Shi, H; Singh, RSP; Toussi, SS; Van Eyck, L | 1 |
| Fan, X; Fu, R; Fu, Y; Jiang, H; Li, J; Lin, C; McCormick, PJ; Yang, Y; Yu, B; Zeng, P; Zhang, J; Zhang, Y; Zhong, F; Zhou, X | 1 |
| Extance, A | 1 |
| Costacurta, F; Geley, S; Harris, RS; Heilmann, E; Mogadashi, SA; Rupp, B; Volland, A; von Laer, D | 1 |
| Cherrington, NJ; Hau, RK; Wright, SH | 1 |
| Ando, H; Atsukawa, M; Ikejima, K; Nagahara, A; Nakadera, E; Okubo, H; Okubo, T | 1 |
| Adachi, E; Chong, Z; Diamond, MS; Douek, DC; Duong, C; Fujisaki, S; Furusawa, Y; Godbole, S; Gordon, A; Hagihara, M; Halfmann, PJ; Hasegawa, H; Hattori, SI; Hojo, M; Iida, S; Imai, M; Ito, M; Iwatsuki-Horimoto, K; Kawaoka, Y; Kiso, M; Koga, M; Kuroda, M; Larson, D; Li, R; Liu, Y; Loeber, S; Maeda, K; Maemura, T; Mitamura, K; Mitsuya, H; Murakami, J; Ohmagari, N; Okuda, M; Ozono, S; Saito, M; Sakai-Tagawa, Y; Sato, T; Suzuki, T; Takashita, E; Tsutsumi, T; Ueki, H; Ujie, M; Uraki, R; Valdez, R; Wang, Z; Watanabe, S; Wright, R; Yamamoto, S; Yamayoshi, S; Yasuhara, A; Yotsuyanagi, H | 1 |
| Chen, JJ; Cheng, PN; Chien, SC; Chiu, HC; Chiu, YC; Lee, PL; Tung, HD | 1 |
| Li, S; Lyu, G; Yang, H; Yang, Y | 1 |
| Burki, T | 1 |
| Bartha, FA; Han, R; Juhász, N; Marzban, S; Röst, G | 1 |
| Alvarado, YJ; González-Paz, L; Hurtado-León, ML; Jeffreys, LN; Loroño, M; Lossada, C; Olivarez, Y; Paz, JL; Torres, FJ; Vera, E; Vera-Villalobos, J; Vivas, A | 1 |
| Anjum Zia, M; Jahan, N; Kiran, S; Mujtaba, N; Naqvi, SAR; Sultana, B | 1 |
| Phizackerley, D | 1 |
| Rubin, R | 1 |
| Collado, A; Corma-Gomez, A; Cucurull, J; Gonzalez-Serna, A; Granados, R; Hernandez-Quero, J; Macias, J; Merino, D; Palacios, R; Pineda, JA; Real, LM; Rios, MJ; Rivero-Juarez, A; Tellez, F | 1 |
| Chan, ECY; Wang, Z | 1 |
| Hui, VK; Kao, JH; Kumar, R; Liu, CH; Tan, J; Tan, SS; Thurairajah, PH; Wong, GH; Wong, YJ | 1 |
| Ackerson, BK; Hong, V; Lewin, BJ; Lewnard, JA; Lipsitch, M; Malden, DE; Tartof, SY | 1 |
| Falade-Nwulia, O; Karimi-Sari, H; Lim, JK; Rezaee-Zavareh, MS | 1 |
| Tanne, JH | 1 |
| Chuang, WL; Dai, CY; Huang, CF; Huang, JF; Yu, ML | 1 |
| Berar Yanay, N; Bogner, I; Saker, K; Tannous, E | 1 |
| Azanza, JR; Barberán, J; González Del Castillo, J; Linares Rufo, M; Madero Valle, N; Mensa, J; Molero, JM | 1 |
| Kesari, S; Kouznetsova, VL; Tsigelny, IF; Yerabandi, N | 1 |
| Allen, R; Alugubelli, YR; Blankenship, LR; Cho, CC; Geng, ZZ; Ji, H; Khatua, K; Li, P; Liu, WR; Ma, XR; Ma, Y; Sankaran, B; Shaabani, N; Vatansever, EC; Xiao, J; Xu, S; Yang, KS; Yu, G | 1 |
| Gao, Y; Lin, Y; Sun, F; Wang, X; Ye, S | 1 |
| Bahmanyar, M; Marzi, M; Vakil, MK; Zarenezhad, E | 1 |
| Chen, SF; Joerger, T; Kushner, LE; Lee, J; Profita, E; Puckett, L | 1 |
| Service, RF | 1 |
| Anderson, AS; Cardin, R; Gribenko, A; Hao, L; Lee, JT; Liberator, PA; Perrin, BS; Yang, Q; Zhu, Y | 1 |
| Kuehn, BM | 1 |
| Cornberg, M; Hidde, D; Klinker, H; Lohmann, K; Lutz, T; Möller, H; Naumann, U; Simon, KG; Stoehr, A; Teuber, G | 1 |
| Altwegg, KA; Chakravarty, D; Chen, Y; Ebrahimi, B; Huang, TH; Krishnan, S; Lai, Z; Li, X; Liu, J; Liu, Z; Ma, S; Mann, M; McHardy, S; Park, BH; Pratap, UP; Raj, GV; Rao, MK; Sanchez, JR; Santhamma, B; Sareddy, GR; Tekmal, RR; Vadlamudi, RK; Vankayalapati, H; Viswanadhapalli, S; Yuan, Y; Zhou, D | 1 |
| Liang, L; Wang, X; Yin, W | 1 |
| Chang, KC; Chang, TS; Chen, CH; Chen, WM; Chen, YH; Hsieh, YY; Hung, CH; Lu, CK; Lu, SN; Lu, YH; Tung, SY; Tung, WL; Yen, CW | 1 |
| Chen, X; Feng, L; Wang, Y; Xiao, W; Zhao, D | 1 |
| Arbel, R; Balicer, R; Battat, E; Ben-Shlomo, Y; Dagan, N; Friger, M; Hammerman, A; Hoshen, M; Lavie, G; Netzer, D; Peretz, A; Serby, D; Sergienko, R; Waxman, JG; Wolff Sagy, Y; Yaron, S | 1 |
| Barclay, ST; Bradley-Stewart, A; Davis, C; Filipe, A; Fox, R; Gunson, R; MacLean, A; Ngan Chiu Bong, M; Peters, ES; Shah, R; Shepherd, SJ; Thomson, EC; Tong, L; van Vliet, VJE | 1 |
| Juárez-López, D; Schcolnik-Cabrera, A | 1 |
| Larkin, HD | 2 |
| Bhattacharya, A; Chauhan, P; Dwivedi, A; Mishra, A; Pandey, S | 1 |
| Anderson, AS; Caubel, P; Rusnak, JM | 1 |
| Adams, E; Charness, ME; Gupta, K; Ho, DD; Lindy, DC; Mohri, H; Stack, G; Strymish, J | 1 |
| Chen, TC; Cheng, TL; Huang, BC; Li, CC; Liao, JM; Lin, WW; Wang, YT | 1 |
| Rosenberg, K | 1 |
| Bhat, IA; Bhat, RAH; Dash, P; Ganie, PA; Gargotra, P; Nazir, MI; Siva, C; Tandel, RS; Yousuf, DJ | 1 |
| Lafree, A; Navarro, MR; Nene, RV; Tomaszewski, CA | 1 |
| Ding, T; Gao, L; Ge, J; Gu, Q; Ma, X; Shen, W; Wang, H; Xue, F; Zhang, X | 1 |
| Ma, X; Wei, Y; Yang, Z; Zhang, W; Zhou, F | 1 |
| Chen, JY; He, Y; Li, YJ; Liu, CH; Lu, Y; Song, ZJ; Wang, YL; Zhu, XQ | 1 |
| Gu, Y; Qiang, W; Sun, Y; Wu, R; Yin, T; Yuan, J | 1 |
| Bai, Y; Chen, Y; Cheng, B; Liu, Y; Xu, S; Yang, X | 1 |
| Li, MH; Qiu, FW; Shen, G; Shi, XL | 1 |
| Brayden, DJ; Byrne, HJ; Frías, JM; Gleeson, JP; Khalid Danish, M; Ryan, SM | 1 |
| Hu, Q; Hua, C; Huo, G; Jiang, H; Li, S; Wu, Y; Zhou, F; Zhu, H | 1 |
| Decker, AP; Mechesso, AF; Wang, G | 1 |
| Ban, Q; Hou, YY; Huang, T; Ma, B; Shi, L; Zhang, ML; Zhang, Q; Zhou, YF | 1 |
| He, X; Li, X; Liu, M; Sun, T; Wang, X | 1 |
| Bian, Q; Chavez, A; Culbertson, B; Duan, Y; Goff, SP; Ho, DD; Hong, SJ; Iketani, S; Lin, M; Liu, X; Lu, Y; Luck, MI; Mohri, H; Rao, Z; Sabo, Y; Sun, H; Wang, H; Yang, H; Yang, K; Yang, X; Zhang, X; Zhou, H; Zhu, Y | 1 |
| Chen, M; Han, M; Meng, X; Wang, S; Wang, Z; Wu, R; Yang, Y; Zhang, J; Zhang, Y; Zhao, Q | 1 |
| Cozzolino, L; Hubbard, PC; McQuaid, CD; Nicastro, KR; Seuront, L; Zardi, GI | 1 |
66 review(s) available for proline and leucine
| Article | Year |
|---|---|
Molecular genetics and transgenic model of Gertsmann-Sträussler-Scheinker disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Codon; Genetic Markers; Gerstmann-Straussler-Scheinker Disease; Humans; Leucine; Mice; Mice, Transgenic; Models, Genetic; Prions; Proline; PrPSc Proteins | 1991 |
The practice and application of electron microscope autoradiography.
Topics: Animals; Autoradiography; Bacillus subtilis; Carbohydrates; Carbon Isotopes; DNA; Emulsions; Escherichia coli; Guinea Pigs; Histocytochemistry; Histological Techniques; L Cells; Leucine; Lipids; Mathematics; Mice; Microscopy, Electron; Microtomy; Neoplasms; Pancreas; Paramecium; Photomicrography; Plants; Proline; Proteins; Radiation Effects; Radioisotopes; Rats; RNA; Staining and Labeling; Sulfur Isotopes; Thymidine; Thyroid Gland; Time Factors; Tritium; Triturus; Viruses; Xenopus | 1971 |
A review of biochemical studies on the genetically distinct collagens of the skeletal system.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Bone and Bones; Cartilage, Articular; Collagen; Glutamates; Homoserine; Hydroxyproline; Leucine; Peptides; Phenylalanine; Proline; Rats; Serine; Threonine; Valine | 1973 |
Utilization of D- and DL- amino acids and analogs.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chickens; Cystine; Histidine; Isomerism; Keto Acids; Leucine; Methionine; Nutritional Requirements; Phenylalanine; Proline; Rats; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1972 |
Genetics of amino acid transport in bacteria.
Topics: Alanine; Amino Acids; Amino Acids, Diamino; Arginine; Asparagine; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Cystine; Energy Metabolism; Escherichia coli; Genes, Regulator; Genetics, Microbial; Glutamates; Glutamine; Glycine; Histidine; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Influence of elevated circulating levels of amino acids on cerebral concentrations and utilization of amino acids.
Topics: Amino Acids; Animals; Biological Transport, Active; Carbon Isotopes; Cerebral Cortex; Fasting; Injections, Intravenous; Leucine; Male; Phenylalanine; Proline; Rats; Time Factors; Valine | 1968 |
Regulation of skeletal growth by sulfation factor.
Topics: Acromegaly; Bone and Bones; Bone Development; Cartilage; Chondroitin; DNA; Dwarfism, Pituitary; Growth Hormone; Humans; Hydrocortisone; Hydroxyproline; Hypophysectomy; Insulin; Leucine; Proline; RNA; Somatomedins; Sulfates; Testosterone | 1971 |
Amino acid degradation by anaerobic bacteria.
Topics: Amino Acids; Anaerobiosis; Aspartic Acid; Clostridium; Culture Media; Glutamates; Glycine; Isoleucine; Leucine; Lysine; Ornithine; Phenylalanine; Proline; Species Specificity; Threonine; Tryptophan; Tyrosine; Valine | 1981 |
An inherited prion disease with a PrP P105L mutation: clinicopathologic and PrP heterogeneity.
Topics: Amino Acid Substitution; Brain; Codon; Female; Humans; Leucine; Male; Methionine; Middle Aged; Mutation, Missense; Nuclear Family; Pedigree; Polymorphism, Genetic; Prion Diseases; Prions; Proline; Valine | 1999 |
R3531C mutation in the apolipoprotein B gene is not sufficient to cause hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Apolipoproteins B; Child; Child, Preschool; Cholesterol, LDL; Female; Haplotypes; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Leucine; Lod Score; Male; Middle Aged; Mutation; Nuclear Family; Pedigree; Polymorphism, Restriction Fragment Length; Proline; Receptors, LDL | 2000 |
Laminopathies affecting skeletal and cardiac muscles: clinical and pathophysiological aspects.
Topics: Animals; Cardiomyopathy, Dilated; Disease Models, Animal; Humans; Lamin Type A; Lamins; Leucine; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophy, Emery-Dreifuss; Myocardium; Nuclear Envelope; Proline | 2005 |
Emerging therapeutic options in hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication | 2011 |
Second-wave protease inhibitors: choosing an heir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2011 |
Hepatitis C direct-acting antiviral agents: changing the paradigm of hepatitis C treatment in HIV-infected patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Coinfection; Hepatitis C; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferons; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2014 |
Faldaprevir (BI 201335) for the treatment of hepatitis C in patients co-infected with HIV.
Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Availability; Clinical Trials as Topic; Coinfection; Drug Administration Schedule; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Virus Replication | 2014 |
Management of HCV patients with cirrhosis with direct acting antivirals.
Topics: Algorithms; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Liver Cirrhosis; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
Treating HCV in HIV 2013: on the cusp of change.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine | 2014 |
Second-wave IFN-based triple therapy for HCV genotype 1 infection: simeprevir, faldaprevir and sofosbuvir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
HCV direct-acting antiviral agents: the best interferon-free combinations.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials as Topic; Disease Eradication; Drug Discovery; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon-alpha; Isoquinolines; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pyrrolidines; Quinolines; Recombinant Proteins; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine; Viral Nonstructural Proteins; Virus Replication | 2014 |
HCV F1/F2 patients: treat now or continue to wait.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Treatment Outcome; Uridine Monophosphate | 2014 |
Hepatitis C virus therapy in the direct acting antiviral era.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Sofosbuvir; Thiazoles; Uridine Monophosphate | 2014 |
Faldaprevir for the treatment of genotype-1 hepatitis C virus.
Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Ribavirin; Thiazoles | 2015 |
Faldaprevir for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2015 |
Faldaprevir for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Discovery; Drug Interactions; Hepatitis C; Humans; Leucine; Molecular Structure; Oligopeptides; Proline; Quinolines; Thiazoles; Tissue Distribution; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
[Preclinical and clinical properties of vaniprevir (VANIHEP® Capsules 150 mg), a novel therapeutic agent for hepatitis C].
Topics: Antiviral Agents; Capsules; Clinical Trials as Topic; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Sulfonamides | 2015 |
Mutational scanning of the CHCHD2 gene in Han Chinese patients with Parkinson's disease and meta-analysis of the literature.
Topics: Adult; Aged; Asian People; DNA Mutational Analysis; DNA-Binding Proteins; Genetic Association Studies; Genotype; Humans; Leucine; Middle Aged; Mitochondrial Proteins; Mutation; Parkinson Disease; Proline; Transcription Factors | 2016 |
The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism.
Topics: Amino Acids; Animals; Astrocytes; Blood Glucose; Dietary Fats; Gluconeogenesis; Glucose; Glycogenolysis; Homeostasis; Humans; Hypothalamus; Leucine; Liver; Neurons; Proline; Vagus Nerve | 2016 |
HCV management in resource-constrained countries.
Topics: Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Carbamates; Continuity of Patient Care; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Drugs, Generic; Fluorenes; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Risk Factors; Sofosbuvir; Sulfonamides; Valine | 2017 |
Sofosbuvir, velpatasvir and voxilaprevir combination for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2017 |
Evaluation of sofosbuvir, velpatasvir plus voxilaprevir as fixed-dose co-formulation for treating hepatitis C.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Interactions; Drug Resistance, Viral; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Tablets; Treatment Outcome | 2017 |
Glecaprevir/Pibrentasvir: First Global Approval.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Approval; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; United States; United States Food and Drug Administration; Viral Nonstructural Proteins | 2017 |
Sofosbuvir/Velpatasvir/Voxilaprevir: A Pan-Genotypic Direct-Acting Antiviral Combination for Hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2018 |
Glecaprevir + pibrentasvir (ABT493 + ABT-530) for the treatment of Hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Combinations; Enzyme Inhibitors; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins | 2018 |
Glecaprevir + pibrentasvir for treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Half-Life; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome | 2018 |
Sofosbuvir/Velpatasvir/Voxilaprevir: A Review in Chronic Hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Approval; Drug Combinations; Drug Resistance, Viral; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; United States; United States Food and Drug Administration; Viral Nonstructural Proteins | 2018 |
Glecaprevir/pibrentasvir expands reach while reducing cost and duration of hepatitis C virus therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Costs; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides | 2018 |
Sofosbuvir, velpatasvir and voxilaprevir combination therapy for treating patients with hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome | 2018 |
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection in adults.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Clinical Trials as Topic; Cyclopropanes; Drug Combinations; Drug Interactions; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2018 |
Sofosbuvir/velpatasvir/voxilaprevir: a highly effective option for retreatment of hepatitis C in difficult-to-treat patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2019 |
Review article: novel antivirals for hepatitis C-sofosbuvir/velpatasvir/voxilaprevir, glecaprevir/pibrentasvir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Clinical Trials, Phase III as Topic; Cyclopropanes; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides | 2018 |
Managing hepatitis C therapy failures and chronic kidney disease.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Cardiovascular Diseases; Cyclopropanes; Drug Combinations; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Sulfonamides; Treatment Failure | 2018 |
Expert opinion on the management of renal manifestations of chronic HCV infection.
Topics: 2-Naphthylamine; Amides; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Benzofurans; Carbamates; Cyclopropanes; Disease Management; Drug Therapy, Combination; Expert Testimony; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Practice Guidelines as Topic; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Risk Factors; Ritonavir; Sulfonamides; Uracil; Valine | 2018 |
Treatment of hepatitis C virus genotype 4 in the DAA era.
Topics: Aminoisobutyric Acids; Anilides; Antiviral Agents; Carbamates; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Interferons; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Valine | 2018 |
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Coinfection; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Fibrosis; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Sulfonamides; Treatment Outcome | 2019 |
Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants.
Topics: 2-Naphthylamine; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Denmark; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Prognosis; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Uracil; Valine | 2019 |
Upcoming direct acting antivirals for hepatitis C patients with a prior treatment failure.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Proline; Quinoxalines; Randomized Controlled Trials as Topic; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure | 2019 |
Successful treatment of chronic hepatitis C virus infection with crushed glecaprevir/pibrentasvir administered via a percutaneous endoscopic gastrostomy tube: case report and review of the literature.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Administration Routes; Drug Therapy, Combination; Female; Gastrostomy; Hepatitis C, Chronic; Humans; Intubation, Gastrointestinal; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2019 |
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Design; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Microbial Sensitivity Tests; Molecular Conformation; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2019 |
Adherence to pan-genotypic glecaprevir/pibrentasvir and efficacy in HCV-infected patients: A pooled analysis of clinical trials.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
New approaches in viraemic organ transplantation and antiviral therapies.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Carcinoma, Hepatocellular; Cyclopropanes; Guanine; Hepatitis B, Chronic; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Liver Transplantation; Macrocyclic Compounds; Proline; Quinoxalines; Salvage Therapy; Sofosbuvir; Sulfonamides; Tenofovir; Transplants | 2020 |
Systematic review with meta-analysis: impact of baseline resistance-associated substitutions on the efficacy of glecaprevir/pibrentasvir among chronic hepatitis C patients.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Non-Randomized Controlled Trials as Topic; Proline; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Viral Nonstructural Proteins | 2020 |
Meeting the WHO hepatitis C virus elimination goal: Review of treatment in paediatrics.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Child; Child, Preschool; Cyclopropanes; Disease Eradication; Drug Therapy, Combination; Fluorenes; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Pediatrics; Proline; Pyrrolidines; Quality of Life; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; World Health Organization | 2020 |
Eight Weeks of Treatment With Glecaprevir/Pibrentasvir Is Safe and Efficacious in an Integrated Analysis of Treatment-Naïve Patients With Hepatitis C Virus Infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Real-World Clinical Practice Use of 8-Week Glecaprevir/Pibrentasvir in Treatment-Naïve Patients with Compensated Cirrhosis.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Genetic Variation; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea | 2022 |
Effect of baseline resistance-associated substitutions on the efficiency of glecaprevir/pibrentasvir in chronic hepatitis C subjects: A meta-analysis.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Glecaprevir/pibrentasvir ultra-short treatment to cure HCV infection: case report and literature review.
Topics: Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Efficacy and Safety of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C: A Pooled Analysis of Five Phase II/III Trials.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Republic of Korea; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2021 |
Successful treatment by glecaprevir/pibrentasvir followed by hepatoprotective therapy of acute chronic hepatitis exacerbation caused by daratumumab-based regimen for multiple myeloma: Case report and review of the literature.
Topics: Aged; Aminoisobutyric Acids; Antibodies, Monoclonal; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Multiple Myeloma; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment.
Topics: Adult; Antiviral Agents; COVID-19; COVID-19 Serotherapy; Humans; Immunization, Passive; Lactams; Leucine; Nitriles; Pandemics; Pharmaceutical Preparations; Proline; Randomized Controlled Trials as Topic; SARS-CoV-2; Treatment Outcome | 2021 |
The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic.
Topics: Antiviral Agents; COVID-19; Drug Delivery Systems; Humans; Lactams; Leucine; Nitriles; Pandemics; Proline; SARS-CoV-2 | 2021 |
Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Fluvoxamine; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
[Nirmatrelvir plus ritonavir (Paxlovid) a potent SARS-CoV-2 3CLpro protease inhibitor combination].
Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Indoles; Lactams; Leucine; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; Pyrrolidinones; Ritonavir; SARS-CoV-2 | 2022 |
The role of BAG3 in dilated cardiomyopathy and its association with Charcot-Marie-Tooth disease type 2.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Cardiomyopathy, Dilated; Charcot-Marie-Tooth Disease; Humans; Leucine; Proline; Protein Aggregates | 2022 |
Paxlovid: Mechanism of Action, Synthesis, and
Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19 Drug Treatment; COVID-19 Vaccines; Cysteine Endopeptidases; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Pandemics; Proline; Protease Inhibitors; Ritonavir; SARS-CoV-2; Viral Nonstructural Proteins | 2022 |
Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer.
Topics: Amino Acids; Arginine; Carbohydrates; Glutamine; Humans; Leucine; Lipids; Male; Proline; Prostatic Neoplasms; Sarcosine; Serine; TOR Serine-Threonine Kinases | 2022 |
115 trial(s) available for proline and leucine
| Article | Year |
|---|---|
Plasma proline and leucine kinetics: response to 4 wk with proline-free diets in young adults.
Topics: Adult; Amino Acids; Caproates; Dietary Proteins; Humans; Infusions, Intravenous; Keto Acids; Leucine; Male; Proline; Single-Blind Method | 1994 |
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Cholesterol; Cholesterol, LDL; Female; Gene Frequency; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Proline; Protein Sorting Signals | 1998 |
Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Burns; Carbon Isotopes; Deuterium; Female; Humans; Kinetics; Leucine; Male; Middle Aged; Nitrogen Isotopes; Ornithine; Oxidation-Reduction; Parenteral Nutrition, Total; Proline | 2001 |
Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women.
Topics: Bone Density; Estrogen Replacement Therapy; Female; Femur Neck; Follow-Up Studies; Humans; Leucine; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Postmenopause; Proline; Protein Precursors; Protein Sorting Signals | 2004 |
Adaptation to a long term (4 weeks) arginine- and precursor (glutamate, proline and aspartate)-free diet.
Topics: Adult; Analysis of Variance; Arginine; Aspartic Acid; Carbon Isotopes; Citrulline; Diet; Dietary Proteins; Female; Glutamic Acid; Homeostasis; Humans; Infusions, Intravenous; Isotope Labeling; Kinetics; Leucine; Male; Nitrogen Isotopes; Oxidation-Reduction; Proline; Time Factors; Urea | 2008 |
Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Dipeptides; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inpatients; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Outpatients; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ritonavir; RNA, Viral; Sulfones; Urea; Young Adult | 2010 |
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Load; Viral Nonstructural Proteins | 2011 |
A new protocol for the treatment of the chronic venous ulcers of the lower limb.
Topics: Administration, Topical; Adolescent; Adult; Aged; Alginates; Cellulose; Chronic Disease; Compression Bandages; Female; Gels; Glucuronic Acid; Glycine; Hexuronic Acids; Humans; Hyaluronic Acid; Leucine; Lower Extremity; Lysine; Male; Middle Aged; Proline; Prospective Studies; Time Factors; Treatment Outcome; Varicose Ulcer; Wound Healing; Young Adult | 2012 |
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Thiazoles; Treatment Outcome; Viral Load; Viral Nonstructural Proteins | 2011 |
PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.
Topics: Adult; Aged; Alanine; Amino Acid Substitution; Dietary Fats; Eating; Female; Gene-Environment Interaction; Genetic Association Studies; Humans; Leucine; Lipids; Male; Middle Aged; Mutation, Missense; Osmolar Concentration; Polymorphism, Single Nucleotide; PPAR alpha; PPAR gamma; Proline; Valine | 2011 |
Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: a randomized phase II study.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Sulfonamides; Young Adult | 2012 |
Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Nonstructural Proteins | 2013 |
A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Young Adult | 2013 |
Sustained virologic response after therapy with the HCV protease inhibitor narlaprevir in combination with peginterferon and ribavirin is durable through long-term follow-up.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Dipeptides; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Placebos; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Sulfones; Treatment Outcome; Urea; Viral Load | 2013 |
Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load | 2013 |
Effects of amino acids enriched tears substitutes on the cornea of patients with dysfunctional tear syndrome.
Topics: Aged; Amino Acids; Cornea; Double-Blind Method; Drug Therapy, Combination; Female; Fluorescein; Fluorescent Dyes; Fluorophotometry; Glycine; Humans; Hyaluronic Acid; Leucine; Lysine; Microscopy, Confocal; Middle Aged; Ophthalmic Nerve; Ophthalmic Solutions; Proline; Prospective Studies; Sjogren's Syndrome; Surveys and Questionnaires; Tears | 2013 |
Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: safety, antiviral activity, resistance, and pharmacokinetics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Carrier Proteins; Cyclopropanes; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Protease Inhibitors; Sulfonamides; Viral Nonstructural Proteins; Young Adult | 2013 |
Emergence of resistance-associated variants after failed triple therapy with vaniprevir in treatment-experienced non-cirrhotic patients with hepatitis C-genotype 1 infection: a population and clonal analysis.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Peptide Hydrolases; Polyethylene Glycols; Proline; Ribavirin; RNA, Viral; Sulfonamides; Treatment Failure; Treatment Outcome; Viremia; Young Adult | 2013 |
Viral resistance in hepatitis C virus genotype 1-infected patients receiving the NS3 protease inhibitor Faldaprevir (BI 201335) in a phase 1b multiple-rising-dose study.
Topics: Aminoisobutyric Acids; Antiviral Agents; Cell Line; Genotype; Genotyping Techniques; Hepacivirus; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2013 |
Faldaprevir and deleobuvir for HCV genotype 1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; DNA-Directed RNA Polymerases; Enzyme Inhibitors; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load | 2013 |
Safety and efficacy of faldaprevir with pegylated interferon alfa-2a and ribavirin in Japanese patients with chronic genotype-1 hepatitis C infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Asian People; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Time Factors; Treatment Outcome | 2014 |
Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis.
Topics: Adolescent; Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Placebos; Proline; Ribavirin; Sulfonamides; Treatment Outcome; Viral Load; Young Adult | 2014 |
Evolutionary dynamics of hepatitis C virus NS3 protease domain during and following treatment with narlaprevir, a potent NS3 protease inhibitor.
Topics: Adult; Antiviral Agents; Cyclopropanes; Dipeptides; Drug Therapy, Combination; Evolution, Molecular; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Leucine; Longitudinal Studies; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sequence Analysis, DNA; Sulfones; Urea; Viral Load; Viral Nonstructural Proteins | 2013 |
Mass balance and metabolite profiling of steady-state faldaprevir, a hepatitis C virus NS3/4 protease inhibitor, in healthy male subjects.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Hepacivirus; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Young Adult | 2014 |
SILEN-C3, a phase 2 randomized trial with faldaprevir plus pegylated interferon α-2a and ribavirin in treatment-naive hepatitis C virus genotype 1-infected patients.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2014 |
Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.
Topics: Acrylates; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Contraindications; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Virus Replication | 2014 |
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir.
Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult | 2014 |
Vaniprevir plus peginterferon alfa-2a and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase II study.
Topics: Adult; Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Sulfonamides; Viral Load; Young Adult | 2015 |
Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.
Topics: Aminoisobutyric Acids; Animals; Bilirubin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Hyperbilirubinemia; Leucine; Liver; Macaca mulatta; Multicenter Studies as Topic; Multidrug Resistance-Associated Protein 2; Oligopeptides; Proline; Quinolines; Randomized Controlled Trials as Topic; Rats; Thiazoles | 2014 |
Interferon-free treatment of chronic hepatitis C with faldaprevir, deleobuvir and ribavirin: SOUND-C3, a Phase 2b study.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Treatment Outcome | 2015 |
Pharmacokinetics, safety, and tolerability of faldaprevir in patients with renal impairment.
Topics: Adult; Aged; Aminoisobutyric Acids; Biological Availability; Female; Half-Life; Hepatitis C; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Renal Insufficiency; Thiazoles | 2015 |
Effect of faldaprevir on raltegravir pharmacokinetics in healthy volunteers.
Topics: Adult; Aminoisobutyric Acids; Drug Administration Schedule; Drug Interactions; Female; Genotype; Glucuronosyltransferase; Healthy Volunteers; HIV Integrase Inhibitors; Humans; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Raltegravir Potassium; Thiazoles; Young Adult | 2015 |
Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Interactions; Female; Humans; Leucine; Male; Methadone; Middle Aged; Oligopeptides; Proline; Quinolines; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles; Young Adult | 2015 |
Effect of the hepatitis C virus protease inhibitor faldaprevir on the pharmacokinetics of an oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aminoisobutyric Acids; Area Under Curve; Bilirubin; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Leucine; Levonorgestrel; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2015 |
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Hepatitis C; Humans; In Vitro Techniques; Isoenzymes; Leucine; Male; Microsomes, Liver; Midazolam; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Warfarin; Young Adult | 2015 |
Efficacy and safety of faldaprevir, deleobuvir, and ribavirin in treatment-naive patients with chronic hepatitis C virus infection and advanced liver fibrosis or cirrhosis.
Topics: Acrylates; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Female; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Ribavirin; Thiazoles; Young Adult | 2015 |
STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles | 2015 |
Faldaprevir and pegylated interferon α-2a/ribavirin in individuals co-infected with hepatitis C virus genotype-1 and HIV.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Leucine; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load; Viremia; Young Adult | 2015 |
Liver-to-plasma vaniprevir (MK-7009) concentration ratios in HCV-infected patients.
Topics: Administration, Oral; Adult; Aged; Antiviral Agents; Biopsy; Cyclopropanes; Drug Monitoring; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Liver Cirrhosis; Male; Middle Aged; Proline; Sulfonamides | 2015 |
Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; Sulfonamides; Treatment Outcome; Young Adult | 2016 |
Open-label study of faldaprevir plus peginterferon and ribavirin in hepatitis C virus genotype 1-infected patients who failed placebo plus peginterferon and ribavirin.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Placebos; Proline; Quinolines; Ribavirin; Salvage Therapy; Thiazoles; Treatment Outcome | 2016 |
ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.
Topics: Acrylates; Aminoisobutyric Acids; Anemia; Antiviral Agents; Benzimidazoles; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Male; Middle Aged; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Pyrophosphatases; Quinolines; Real-Time Polymerase Chain Reaction; Ribavirin; Thiazoles | 2015 |
Potent Antiviral Activities of the Direct-Acting Antivirals ABT-493 and ABT-530 with Three-Day Monotherapy for Hepatitis C Virus Genotype 1 Infection.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Microbial Sensitivity Tests; Middle Aged; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Young Adult | 2015 |
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 (GT1b) infection: Phase 3 studies.
Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Recurrence; Ribavirin; RNA, Viral; Sulfonamides; Viral Load; Young Adult | 2016 |
HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials.
Topics: Amino Acid Substitution; Antiviral Agents; Codon; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Evolution, Molecular; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mutation; Phylogeny; Proline; Sequence Analysis, DNA; Sulfonamides; Treatment Failure; Treatment Outcome | 2016 |
GS-9857 in patients with chronic hepatitis C virus genotype 1-4 infection: a randomized, double-blind, dose-ranging phase 1 study.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Placebos; Proline; Quinoxalines; Sulfonamides; Treatment Outcome; Viral Load; Young Adult | 2016 |
A Protease Inhibitor with Induction Therapy with Natural Interferon-β in Patients with HCV Genotype 1b Infection.
Topics: Aged; Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Indoles; Interferon-beta; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polyethylene Glycols; Proline; Protease Inhibitors; Ribavirin; Simeprevir; Sulfonamides | 2016 |
Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Food-Drug Interactions; Healthy Volunteers; Hepacivirus; Humans; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Oligopeptides; Omeprazole; Proline; Protease Inhibitors; Proton Pump Inhibitors; Quinolines; Risk Factors; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2016 |
Short article: Faldaprevir, deleobuvir and ribavirin in IL28B non-CC patients with HCV genotype-1a infection included in the SOUND-C3 phase 2b study.
Topics: Acrylates; Adult; Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Leucine; Male; Middle Aged; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA, Viral; Sustained Virologic Response; Thiazoles; Time Factors; Treatment Outcome; United States | 2016 |
Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; New Zealand; Proline; Protease Inhibitors; Quinoxalines; Serine Proteases; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Viral Nonstructural Proteins; Young Adult | 2016 |
High Efficacy of ABT-493 and ABT-530 Treatment in Patients With HCV Genotype 1 or 3 Infection and Compensated Cirrhosis.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Fibrosis; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides; Sustained Virologic Response | 2016 |
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Serine Proteases; Sofosbuvir; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins; Young Adult | 2016 |
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Genotype 1 Hepatitis C Virus Infection in an Open-Label, Phase 2 Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Ribavirin; Serine Proteases; Sofosbuvir; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins; Young Adult | 2016 |
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of ABT-493: A First-In-Human Study.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Administration Schedule; Female; Food-Drug Interactions; Hepatitis; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Placebo Effect; Proline; Quinoxalines; Sulfonamides | 2017 |
HCVerso3: An Open-Label, Phase IIb Study of Faldaprevir and Deleobuvir with Ribavirin in Hepatitis C Virus Genotype-1b-Infected Patients with Cirrhosis and Moderate Hepatic Impairment.
Topics: Acrylates; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Prognosis; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Viral Load; Young Adult | 2016 |
Glecaprevir and pibrentasvir for 12 weeks for hepatitis C virus genotype 1 infection and prior direct-acting antiviral treatment.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Confidence Intervals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Lactams, Macrocyclic; Leucine; Liver Function Tests; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retreatment; Ribavirin; Sulfonamides; Time Factors; Treatment Outcome; United States; Viral Load; Young Adult | 2017 |
Sofosbuvir-velpatasvir-voxilaprevir with or without ribavirin in direct-acting antiviral-experienced patients with genotype 1 hepatitis C virus.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Confidence Intervals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Prospective Studies; Quinoxalines; Ribavirin; Severity of Illness Index; Sofosbuvir; Sulfonamides; Treatment Outcome; Young Adult | 2017 |
Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Young Adult | 2017 |
Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides; Sustained Virologic Response; Treatment Failure | 2017 |
Effect of Steady-State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open-Label, Fixed-Sequence Crossover Study.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Atorvastatin; Cross-Over Studies; Drug Interactions; Female; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Male; Middle Aged; Oligopeptides; Proline; Pyrimidines; Quinolines; Rosuvastatin Calcium; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles | 2017 |
Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Proline; Protease Inhibitors; Quinoxalines; Sofosbuvir; Sulfonamides; Viral Nonstructural Proteins | 2017 |
Pharmacokinetic Interactions and Safety of Coadministration of Glecaprevir and Pibrentasvir in Healthy Volunteers.
Topics: Adolescent; Adult; Alanine Transaminase; Aminoisobutyric Acids; Antiviral Agents; Aspartate Aminotransferases; Benzimidazoles; Bilirubin; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Female; Healthy Volunteers; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Young Adult | 2018 |
No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cyclopropanes; Drug Interactions; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Methadone; Middle Aged; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Surveys and Questionnaires; Young Adult | 2017 |
Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2017 |
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response | 2018 |
Glecaprevir/pibrentasvir for hepatitis C virus genotype 3 patients with cirrhosis and/or prior treatment experience: A partially randomized phase 3 clinical trial.
Topics: Adult; Aged; Alanine Transaminase; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response | 2018 |
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ritonavir; RNA, Viral; Sulfonamides; Sustained Virologic Response; Valine; Viral Nonstructural Proteins | 2018 |
Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Placebos; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome | 2018 |
Glecaprevir and Pibrentasvir in Patients with HCV and Severe Renal Impairment.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; RNA, Viral; Sulfonamides; Viral Load | 2017 |
Characterization of HCV resistance from a 3-day monotherapy study of voxilaprevir, a novel pangenotypic NS3/4A protease inhibitor.
Topics: Aminoisobutyric Acids; Cell Line; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Protease Inhibitors; Quinoxalines; RNA, Viral; Sequence Analysis, RNA; Sulfonamides; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2018 |
IFNL4 Genotype Is Associated With Virologic Relapse After 8-Week Treatment With Sofosbuvir, Velpatasvir, and Voxilaprevir.
Topics: Aminoisobutyric Acids; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Interleukins; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Recurrence; Sofosbuvir; Sulfonamides; Sustained Virologic Response | 2017 |
Glecaprevir/Pibrentasvir in patients with hepatitis C virus genotype 1 or 4 and past direct-acting antiviral treatment failure.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome; Young Adult | 2018 |
Integrated Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in Japan.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoquinolines; Japan; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Viral Nonstructural Proteins | 2018 |
Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Benzimidazoles; Cyclopropanes; Drug Administration Schedule; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepacivirus; Hepatitis C; Humans; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Renal Dialysis; Renal Insufficiency, Chronic; Sulfonamides | 2018 |
Glecaprevir-Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sofosbuvir; Sulfonamides; Valine; Viral Load | 2018 |
Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Graft Rejection; Healthy Volunteers; Hepatitis C; Humans; Immunosuppressive Agents; Leucine; Liver Transplantation; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Quinolines; Secondary Prevention; Tacrolimus; Thiazoles; Young Adult | 2018 |
A Phase 1 Study to Evaluate the Effect of Crushing, Cutting Into Half, or Grinding of Glecaprevir/Pibrentasvir Tablets on Exposures in Healthy Subjects.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Benzimidazoles; Biological Availability; Cross-Over Studies; Cyclopropanes; Female; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Particle Size; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Tablets | 2018 |
High SVR12 with 8-week and 12-week glecaprevir/pibrentasvir therapy: An integrated analysis of HCV genotype 1-6 patients without cirrhosis.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Time Factors; Treatment Outcome | 2018 |
Glecaprevir/Pibrentasvir Treatment in Liver or Kidney Transplant Patients With Hepatitis C Virus Infection.
Topics: Adult; Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Graft Rejection; Graft Survival; Hepatitis C, Chronic; Humans; Internationality; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Liver Transplantation; Male; Middle Aged; Prognosis; Proline; Pyrrolidines; Quinoxalines; Risk Assessment; Sulfonamides; Transplant Recipients; Treatment Outcome | 2018 |
Deferred treatment with sofosbuvir-velpatasvir-voxilaprevir for patients with chronic hepatitis C virus who were previously treated with an NS5A inhibitor: an open-label substudy of POLARIS-1.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; RNA, Viral; Sofosbuvir; Sulfonamides; Treatment Failure; Viral Nonstructural Proteins | 2018 |
Viral eradication is required for sustained improvement of patient-reported outcomes in patients with hepatitis C.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Linear Models; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Multivariate Analysis; Patient Reported Outcome Measures; Proline; Quality of Life; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response | 2019 |
Pooled Resistance Analysis in Patients with Hepatitis C Virus Genotype 1 to 6 Infection Treated with Glecaprevir-Pibrentasvir in Phase 2 and 3 Clinical Trials.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response | 2018 |
No impact of resistance-associated substitutions on the efficacy of sofosbuvir, velpatasvir, and voxilaprevir for 12 weeks in HCV DAA-experienced patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; High-Throughput Nucleotide Sequencing; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome; Viral Nonstructural Proteins | 2018 |
Resistance Analysis of a 3-Day Monotherapy Study with Glecaprevir or Pibrentasvir in Patients with Chronic Hepatitis C Virus Genotype 1 Infection.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Fibrosis; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Viral Load | 2018 |
Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures.
Topics: Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Recurrence; Retreatment; Sulfonamides; Treatment Failure; Treatment Outcome | 2019 |
Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial.
Topics: Adult; Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Combinations; Fatigue; Female; Genotype; Headache; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult | 2019 |
Glecaprevir/Pibrentasvir in patients with chronic HCV genotype 3 infection: An integrated phase 2/3 analysis.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult | 2019 |
Glecaprevir/pibrentasvir in patients with chronic HCV and recent drug use: An integrated analysis of 7 phase III studies.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Drug Users; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult | 2019 |
Safety and efficacy of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C in patients aged 65 years or older.
Topics: Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Kidney; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome | 2019 |
Sofosbuvir/Velpatasvir/Voxilaprevir for patients with HCV who previously received a Sofosbuvir/Velpatasvir-containing regimen: Results from a retreatment study.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Sustained Virologic Response | 2019 |
A prospective study of daclatasvir and sofosbuvir in chronic HCV-infected kidney transplant recipients.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Biopsy, Needle; Calcineurin Inhibitors; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Glucose Intolerance; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Kidney Failure, Chronic; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Liver; Macrocyclic Compounds; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; RNA, Viral; Salvage Therapy; Sofosbuvir; Sulfonamides; Treatment Outcome; Valine; Viral Load; Viral Nonstructural Proteins; Viremia | 2019 |
Retreatment of patients who failed glecaprevir/pibrentasvir treatment for hepatitis C virus infection.
Topics: Adult; Aged; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure | 2019 |
The efficacy and safety of glecaprevir plus pibrentasvir in 141 patients with severe renal impairment: a prospective, multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Renal Dialysis; Renal Insufficiency, Chronic; Severity of Illness Index; Sulfonamides; Sustained Virologic Response | 2019 |
Safety and Pharmacokinetics of Glecaprevir/Pibrentasvir in Adults With Chronic Genotype 1-6 Hepatitis C Virus Infections and Compensated Liver Disease.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Liver Diseases; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response | 2019 |
A pilot study of safety and efficacy of HCV retreatment with sofosbuvir/velpatasvir/voxilaprevir in patients with or without HIV (RESOLVE STUDY).
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; HIV Infections; HIV-1; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Pilot Projects; Proline; Quinoxalines; Recurrence; RNA, Viral; Sofosbuvir; Sulfonamides; Sustained Virologic Response | 2019 |
Effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C previously treated with DAAs.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Monitoring; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Spain; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2019 |
Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Benzimidazoles; Biological Availability; Body Weight; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Female; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Models, Biological; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Young Adult | 2020 |
Simplified monitoring for hepatitis C virus treatment with glecaprevir plus pibrentasvir, a randomised non-inferiority trial.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Drug Monitoring; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Young Adult | 2020 |
Glecaprevir/pibrentasvir for 8 weeks in treatment-naïve patients with chronic HCV genotypes 1-6 and compensated cirrhosis: The EXPEDITION-8 trial.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Sustained Virologic Response; Viral Nonstructural Proteins | 2020 |
Efficacy and safety of glecaprevir/pibrentasvir in renally impaired patients with chronic HCV infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Fine-Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection.
Topics: Adult; Antiviral Agents; Biopsy, Fine-Needle; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Male; Middle Aged; Proline; Sulfonamides; Tissue Distribution; Young Adult | 2020 |
Efficacy and safety of glecaprevir/pibrentasvir in patients with HCV genotype 5/6: An integrated analysis of phase 2/3 studies.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2020 |
[Efficacy and safety of narlaprevir/ritonavir and daclatasvir non interferon combination in population of Russian patients with chronic hepatitis C].
Topics: Adult; Antiviral Agents; Carbamates; Cyclopropanes; Dipeptides; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Leucine; Middle Aged; Proline; Pyrrolidines; Ritonavir; Russia; Sulfones; Treatment Outcome; Urea; Valine | 2019 |
A Thorough QT Study of the Combination Glecaprevir + Pibrentasvir on Cardiac Repolarization in Healthy Subjects.
Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Combinations; Electrocardiography; Female; Healthy Volunteers; Heart; Heart Rate; Humans; Lactams, Macrocyclic; Leucine; Long QT Syndrome; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Single-Blind Method; Sulfonamides; Young Adult | 2020 |
Glecaprevir-pibrentasvir to treat chronic hepatitis C virus infection in Asia: two multicentre, phase 3 studies- a randomised, double-blind study (VOYAGE-1) and an open-label, single-arm study (VOYAGE-2).
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Asia; Benzimidazoles; Case-Control Studies; Cyclopropanes; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Placebos; Prevalence; Proline; Pyrrolidines; Quinoxalines; Respiratory Tract Infections; Safety; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2020 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea | 2022 |
Multicenter Study to Transplant Hepatitis C-Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection.
Topics: Adult; Allografts; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Glomerular Filtration Rate; Hepacivirus; Hepatitis C; Humans; Kidney; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Male; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; RNA, Viral; Sulfonamides; Sustained Virologic Response | 2020 |
Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Pilot Projects; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides; Sustained Virologic Response | 2021 |
Positive predictive value of sustained virologic response 4 weeks posttreatment for achieving sustained virologic response 12 weeks posttreatment in patients receiving glecaprevir/pibrentasvir in Phase 2 and 3 clinical trials.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Predictive Value of Tests; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2021 |
An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19.
Topics: Adenosine Monophosphate; Aged; Alanine; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Double-Blind Method; Drug Approval; Drug Combinations; Female; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Male; Middle Aged; Nitriles; Proline; Ritonavir; SARS-CoV-2; Severity of Illness Index; Treatment Outcome | 2022 |
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
Topics: Administration, Oral; Adult; Antiviral Agents; COVID-19 Drug Treatment; Disease Progression; Double-Blind Method; Hospitalization; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Treatment Outcome; Vaccination; Viral Load; Viral Protease Inhibitors | 2022 |
Safety and efficacy of sofosbuvir-velpatasvir-voxilaprevir for re-treatment of chronic hepatitis C virus infection in patients with previous direct-acting antiviral treatment failure in Rwanda (SHARED-3): a single-arm trial.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Death, Sudden; Female; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Quinoxalines; Rwanda; Sofosbuvir; Sulfonamides; Treatment Failure | 2022 |
Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin-A Randomized Controlled Clinical Trial.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; COVID-19; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Pandemics; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sulfonamides | 2022 |
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
1481 other study(ies) available for proline and leucine
| Article | Year |
|---|---|
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Topics: Amino Acid Transport Systems; Caco-2 Cells; Endocytosis; Humans; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters | 2011 |
Basic and neutral amino acid transport in Aspergillus nidulans.
Topics: Amino Acids; Arginine; Aspergillus nidulans; Azides; Binding, Competitive; Biological Transport, Active; Cycloheximide; Fungal Proteins; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Membrane Transport Proteins; Methionine; Mutation; Ornithine; Phenylalanine; Proline; Serine | 1976 |
Effects of Na+ depletion, theophylline and 2,4-dinitrophenol on neutral amino acid influx and cyclic adenosine 3':5'-monophosphate levels in chicken small intestine.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Chickens; Cyclic AMP; Dinitrophenols; Glycine; Intestinal Mucosa; Intestine, Small; Kinetics; Leucine; Male; Proline; Sodium; Theophylline | 1976 |
Chiroptical properties of fluorescamine condensation compounds with secondary amino acids in situ.
Topics: Amino Acids; Binding Sites; Chemical Phenomena; Chemistry; Circular Dichroism; Fluorescamine; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Conformation; Proline; Spiro Compounds | 1976 |
Adaptive enhancement of amino acid uptake and exodus by thymic lymphocytes: influence of pH.
Topics: Aminoisobutyric Acids; Animals; Biological Transport, Active; Culture Media; Cycloheximide; Dactinomycin; Hydrogen-Ion Concentration; Kinetics; Leucine; Proline; Rats; T-Lymphocytes; Time Factors | 1976 |
Peptides related to melanostatin (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor.
Topics: Animals; Glycine; Leucine; Male; Mice; MSH Release-Inhibiting Hormone; Oxotremorine; Peptides; Proline; Tremor | 1976 |
The fluorescence of fluorescamine-amino acids.
Topics: Alanine; Amino Acids; Chemical Phenomena; Chemistry, Physical; Fluorescamine; Hydrogen-Ion Concentration; Kinetics; Leucine; Proline; Spectrometry, Fluorescence; Spiro Compounds; Tryptophan | 1978 |
Nuclear-magnetic-resonance study of aggregations and conformations of melanostatin and related peptides.
Topics: Glycine; Leucine; Magnetic Resonance Spectroscopy; MSH Release-Inhibiting Hormone; Proline; Protein Binding; Protein Conformation; Structure-Activity Relationship | 1978 |
Metabolic changes in Crithidia fasciculata accompanying physiological adaptation to growth in the presence of carbonyl cyanide m-chlorophenylhydrazone.
Topics: Adaptation, Physiological; Adenine Nucleotides; Alanine; Animals; Biological Transport; Carbon Dioxide; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Crithidia; Energy Metabolism; Hydrogen-Ion Concentration; Leucine; Nitriles; Oxygen Consumption; Proline; Tyrosine | 1979 |
Autoradiographic demonstration of afferent connections of the accessory olfactory bulb in the mouse.
Topics: Amygdala; Animals; Autoradiography; Axonal Transport; Brain Mapping; Female; Leucine; Male; Mice; Nasal Septum; Neural Pathways; Neurons, Afferent; Olfactory Bulb; Peripheral Nerves; Proline; Tritium | 1975 |
Substrate specificity of the amino acyl adenylate activation sites of gramicidin S-synthetase (GSS).
Topics: Acetylation; Adenosine Monophosphate; Amino Acid Isomerases; Amino Acids; Bacillus; Binding Sites; Esters; Gramicidin; Leucine; Lysine; Multienzyme Complexes; Ornithine; Peptide Synthases; Phenylalanine; Proline; Stereoisomerism; Valine | 1975 |
A light microscopic, autoradiographic study of axoplasmic transport in the normal rhesus optic nerve head.
Topics: Animals; Autoradiography; Axonal Transport; Axons; Haplorhini; Leucine; Macaca mulatta; Optic Nerve; Proline; Retina; Tritium | 1976 |
Uptake of L-proline by Histoplasma capsulatum.
Topics: Amino Acids; Azetidinecarboxylic Acid; Biological Transport, Active; Carboxylic Acids; Diffusion; Histoplasma; Leucine; Proline; Sarcosine; Stereoisomerism | 1976 |
Efferents from medial basal forebrain and hypothalamus in the rat. I. An autoradiographic study of the medial preoptic area.
Topics: Animals; Autoradiography; Axonal Transport; Efferent Pathways; Female; Hypothalamus; Leucine; Male; Preoptic Area; Proline; Rats | 1976 |
Efferents from medial basal forebrain and hypothalamus in the rat. II. An autoradiographic study of the anterior hypothalamus.
Topics: Animals; Autoradiography; Axonal Transport; Efferent Pathways; Female; Hypothalamus; Hypothalamus, Anterior; Leucine; Male; Proline; Rats | 1976 |
The topographical organization of the olivo-dentate and dentato-olivary pathways in the cat.
Topics: Animals; Axonal Transport; Cats; Cerebellar Nuclei; Horseradish Peroxidase; Leucine; Neural Pathways; Olivary Nucleus; Proline | 1976 |
The efferent connections of the ventromedial nucleus of the hypothalamus of the rat.
Topics: Animals; Axonal Transport; Brain; Efferent Pathways; Hypothalamus; Hypothalamus, Middle; Leucine; Lysine; Proline; Rats | 1976 |
Direct hypothalamo-autonomic connections.
Topics: Animals; Axonal Transport; Brain Stem; Cats; Haplorhini; Horseradish Peroxidase; Hypothalamus; Leucine; Lysine; Macaca fascicularis; Neural Pathways; Proline; Rats; Spinal Cord; Sympathetic Nervous System; Vagus Nerve | 1976 |
A light microscopic, autoradiographic study of axoplasmic transport in the optic nerve head during ocular hypotony, increased intraocular pressure, and papilledema.
Topics: Animals; Anterior Chamber; Autoradiography; Axonal Transport; Cryosurgery; Glaucoma; Haplorhini; Intraocular Pressure; Leucine; Macaca mulatta; Optic Disk; Optic Nerve; Papilledema; Proline; Sclera; Tritium | 1976 |
Reutilization of precursor following axonal transport of [3H]proline-labeled protein.
Topics: Acetohexamide; Animals; Asparagine; Axonal Transport; Axons; Cycloheximide; Goldfish; Hydroxyproline; Leucine; Nerve Tissue Proteins; Optic Nerve; Proline; Superior Colliculi | 1977 |
Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis).
Topics: Amygdala; Animals; Axonal Transport; Cerebral Cortex; Efferent Pathways; Leucine; Nerve Degeneration; Olfactory Bulb; Olfactory Pathways; Proline; Shrews | 1977 |
An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat.
Topics: Animals; Autoradiography; Axonal Transport; Cerebral Cortex; Efferent Pathways; Hippocampus; Leucine; Lysine; Proline; Rats | 1977 |
Differential distribution of corticospinal projections from individual cytoarchitectonic fields in the monkey.
Topics: Animals; Axonal Transport; Cerebral Cortex; Haplorhini; Leucine; Macaca fascicularis; Neural Pathways; Proline; Spinal Cord | 1977 |
Evidence for selective axon-terminal uptake and retrograde transport of label in cortico- and rubrospinal systems after injection of 3H-proline.
Topics: Afferent Pathways; Animals; Axonal Transport; Geniculate Bodies; Haplorhini; Leucine; Macaca mulatta; Motor Cortex; Olivary Nucleus; Proline; Red Nucleus; Reticular Formation; Spinal Cord; Synapses | 1977 |
Rapid axoplasmic transport in the olfactory nerve of the pike: I. Basic transport parameters for proteins and amino acids.
Topics: Amino Acids; Animals; Axonal Transport; Female; Fishes; Leucine; Male; Nerve Tissue Proteins; Olfactory Bulb; Olfactory Mucosa; Olfactory Nerve; Proline; Temperature; Tritium | 1978 |
Rapid axoplasmic transport in the olfactory nerve of the pike: II. Analysis of transported proteins by SDS gel electrophoresis.
Topics: Animals; Axonal Transport; Electrophoresis, Polyacrylamide Gel; Fishes; Leucine; Molecular Weight; Nerve Tissue Proteins; Olfactory Bulb; Olfactory Mucosa; Olfactory Nerve; Proline; Receptors, Neurotransmitter; Sodium Dodecyl Sulfate; Tritium | 1978 |
Projections of auditory nerve in the cat as seen by anterograde transport methods.
Topics: Animals; Axonal Transport; Cats; Cochlear Nerve; Fucose; Leucine; Medulla Oblongata; Proline; Vestibulocochlear Nerve | 1979 |
Connectivity of the auditory forebrain nuclei in the guinea fowl (Numida meleagris).
Topics: Animals; Auditory Cortex; Autoradiography; Birds; Brain Mapping; Female; Leucine; Male; Neural Pathways; Proline; Silver; Staining and Labeling; Tritium | 1979 |
Olivocerebellar projections in the cat studied by means of anterograde axonal transport of labelled amino acids as tracers.
Topics: Afferent Pathways; Amino Acids; Animals; Autoradiography; Axonal Transport; Cats; Cerebellum; Cerebral Cortex; Efferent Pathways; Leucine; Olivary Nucleus; Proline; Tritium | 1979 |
Superior colliculus efferents to the hypothalamus.
Topics: Adenosine; Animals; Autoradiography; Axonal Transport; Efferent Pathways; Female; Hypothalamus; Hypothalamus, Anterior; Leucine; Male; Microscopy, Electron; Proline; Rabbits; Rats; Superior Colliculi; Supraoptic Nucleus | 1979 |
Odontoblast metabolism in rats deficient in vitamin D and calcium. III. Protein synthesis in vitro.
Topics: Animals; Body Weight; Calcium; Cells, Cultured; Fucose; Leucine; Male; Odontoblasts; Phosphates; Proline; Protein Biosynthesis; Rats; Vitamin D Deficiency | 1978 |
The unstable Hb Genova (beta 28Leu replaced by Pro) in an East African Family. Family study and the effect of splenectomy.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Kenya; Leucine; Male; Middle Aged; Pedigree; Pregnancy; Proline; Splenectomy | 1979 |
Rabbit cranial sutures in vitro: a new experimental model for studying the response of fibrous joints to mechanical stress.
Topics: Animals; Collagen; Hydroxyproline; Leucine; Models, Biological; Organ Culture Techniques; Proline; Proteins; Rabbits; Skull; Stress, Mechanical; Tensile Strength; Tritium | 1979 |
The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats.
Topics: Amino Acids; Aminobutyrates; Animals; Arsenates; Arsenic; Aspartic Acid; Betaine; Circadian Rhythm; Erythrocytes; Female; Glutamine; Glycine; Hydroxyproline; Isoleucine; Leucine; Male; Ornithine; Proline; Rats; Serine; Sex Factors; Starvation; Taurine; Valine | 1979 |
Stimulation of growth and mucopolysaccharide synthesis by insulin treatment of chick embryo chondrocytes in cell culture.
Topics: Acetates; Amino Acids; Animals; Ascorbic Acid; Blood; Cartilage; Cattle; Cells, Cultured; Chick Embryo; Collagen; Glycosaminoglycans; Insulin; Leucine; Proline; Sulfur Radioisotopes; Sulfuric Acids; Tritium | 1975 |
Transport of sugars and amino acids in bacteria. XIV. Preferential inhibition of oxidase activities and active transport reactions for amino acids by azidebenzenes.
Topics: Adenosine Triphosphatases; Amino Acids; Azides; Biological Transport, Active; Escherichia coli; Glycerol; Isoleucine; Leucine; Oxidation-Reduction; Oxygen Consumption; Proline; Succinate Dehydrogenase; Succinates | 1975 |
Energy coupling in the active transport of amino acids by bacteriohodopsin-containing cells of Halobacterium holobium.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acids; Bacteriorhodopsins; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dicyclohexylcarbodiimide; Glycerol; Halobacterium; Histidine; Leucine; Light; Photophosphorylation; Proline | 1976 |
Effects of estrogen to alter amino acid transport in R3230AC mammary carcinomas and its relationship to insulin action.
Topics: Adenocarcinoma; Amino Acids; Animals; Biological Transport; Castration; Cell Line; Diabetes Mellitus, Experimental; Estradiol; Estrogens; Female; In Vitro Techniques; Insulin; Insulin Antagonists; Leucine; Mammary Neoplasms, Experimental; Proline; Rats; RNA, Neoplasm; Streptozocin; Substrate Specificity; Time Factors | 1979 |
Tyrocidine synthetase system.
Topics: Aminoacylation; Asparagine; Bacillus; Cell Division; Chromatography, DEAE-Cellulose; Glutamine; Leucine; Ligases; Methods; Molecular Weight; Multienzyme Complexes; Ornithine; Phenylalanine; Proline; Time Factors; Tyrocidine; Tyrosine; Tyrothricin; Valine | 1975 |
Programmed synthesis of collagen during postembryonic development of the nematode Panagrellus silusiae.
Topics: Animals; Collagen; Hydroxyproline; Leucine; Nematoda; Procollagen-Proline Dioxygenase; Proline; Time Factors; Tryptophan | 1975 |
Collagen biosynthesis by cultured Chinese hamster lung cells. Cell-free synthesis of procollagen alpha chains.
Topics: Cell Line; Cell-Free System; Leucine; Macromolecular Substances; Microbial Collagenase; Molecular Weight; Procollagen; Proline | 1978 |
Protein synthesis of the peritoneal membrane and intra-abdominal adhaesions in silica-induced peritonitis.
Topics: Animals; Collagen; Injections, Intraperitoneal; Leucine; Male; Mucous Membrane; Peritoneum; Peritonitis; Proline; Protein Biosynthesis; Rats; Silicon Dioxide; Tissue Adhesions | 1977 |
Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study.
Topics: Amino Acids; Animals; Autoradiography; D-Amino-Acid Oxidase; Injections, Intraperitoneal; Kidney Tubules; Kidney Tubules, Proximal; Leucine; Liver; Male; Proline; Rats; Time Factors; Tritium | 1975 |
Formation and excretion of pyrrole-2-carboxylic acid. Whole animal and enzyme studies in the rat.
Topics: Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Amino Acids; Animals; Carboxylic Acids; Catalase; Cattle; Chromatography, Ion Exchange; D-Amino-Acid Oxidase; Guinea Pigs; Humans; Hydroxyproline; Kidney; Kinetics; Leucine; Liver; Proline; Pyrroles; Rats; Swine | 1975 |
Haemoglobin Saki alpha 2 beta 2 14 Leu-Pro(a11) structure and function.
Topics: Adult; Amino Acid Sequence; Amino Acids; Diphosphoglyceric Acids; Drug Stability; Female; France; Hemoglobins, Abnormal; Hot Temperature; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Japan; Kinetics; Leucine; Oxygen; Peptide Fragments; Proline; Protein Binding; Time Factors; Trypsin | 1975 |
Isolation and functional characterization of hemoglobin Casper: beta106(G8) Leu replaced by Pro.
Topics: Diphosphoglyceric Acids; England; Erythrocytes; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Leucine; Oxygen; Proline | 1975 |
A comparison of collagen and non-collagenous protein metabolism in rat molar and incisor periodontal ligaments.
Topics: Amino Acids; Animals; Collagen; Incisor; Leucine; Male; Molar; Periodontal Ligament; Proline; Proteins; Rats; Time Factors | 1978 |
Alteration of free serum amino acids in voles infected with Trypanosoma brucei gambiense.
Topics: Alanine; Amino Acids; Animals; Arvicolinae; Circadian Rhythm; Glutamates; Glycine; Isoleucine; Leucine; Male; Proline; Serine; Threonine; Trypanosomiasis, African; Tryptophan; Tyrosine; Valine | 1977 |
Incorporation of 14C-amino acids into rat hypothalamus in vitro.
Topics: Amino Acids; Animals; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Leucine; Male; Oxytocin; Proline; Protein Biosynthesis; Rats | 1977 |
Study of the transfer RNAs coded by T2, T4, and T6 bacteriophages.
Topics: Arginine; Base Sequence; Chromatography; Coliphages; DNA, Viral; Escherichia coli; Glycine; Isoleucine; Leucine; Nucleic Acid Hybridization; Proline; RNA, Transfer; RNA, Viral | 1977 |
Relationship between messenger ribonucleic acid and enzyme levels specified by the leucine operon of Escherichia coli K-12.
Topics: 2-Isopropylmalate Synthase; Culture Media; Escherichia coli; Leucine; Operon; Oxidoreductases; Oxo-Acid-Lyases; Plasmids; Proline; RNA, Bacterial; RNA, Messenger | 1977 |
Branched-chain amino acid transport regulation in mutants blocked in tRNA maturation and transcriptional termination.
Topics: Amino Acids; Biological Transport, Active; Escherichia coli; Genes; Isoleucine; Leucine; Proline; Rho Factor; RNA, Bacterial; RNA, Transfer; Transcription Factors; Valine | 1978 |
A single mutation affects L-serine deaminase, L-leucyl-, L-phenylalanyl-tRNA protein transferase, and proline oxidase activity in Escherichia coli K-12.
Topics: Acyltransferases; Enzyme Induction; Escherichia coli; Genes; L-Serine Dehydratase; Leucine; Maltose; Mutation; Oxygenases; Proline; RNA, Transfer | 1978 |
Regulation of cell size in the yeast Saccharomyces cerevisiae.
Topics: Ammonium Sulfate; Cell Cycle; Culture Media; Leucine; Proline; Saccharomyces cerevisiae | 1979 |
Regulation of proline dehydrogenase activity in Escherichia coli by leucyl-, phenylalanyl-tRNA:protein transferase.
Topics: Acyltransferases; Escherichia coli; Leucine; Molecular Weight; Oxygenases; Phenylalanine; Proline; RNA, Transfer, Amino Acyl; Species Specificity | 1979 |
Pools and protein synthesis in mammalian cells.
Topics: Amino Acids; Animals; Cell Line; Cricetinae; Glycine; HeLa Cells; Kinetics; Leucine; p-Fluorophenylalanine; Phenylalanine; Proline; Protein Biosynthesis | 1979 |
Proline oxidase in cultured mammalian cells.
Topics: Animals; Carbon Dioxide; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Fibroblasts; Humans; Hydroxyproline; Kidney; Leucine; Leukocytes; Mice; Mitochondria; Mitochondria, Liver; Oxidoreductases Acting on CH-NH Group Donors; Proline; Rabbits; Rats; Stereoisomerism | 1977 |
Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for the analysis of peptide hormone interactions with bovine neurophysin I using 13C nuclear magnetic resonance spectroscopy.
Topics: Animals; Binding Sites; Carbon Isotopes; Cattle; Leucine; Magnetic Resonance Spectroscopy; Neurophysins; Oxytocin; Proline; Protein Binding; Protein Conformation | 1977 |
Inhibitory effects of tunicamycin on procollagen biosynthesis and secretion.
Topics: Animals; Anti-Bacterial Agents; Chick Embryo; Glucosamine; Glycine; Guanosine Diphosphate Mannose; Leucine; Mannose; Procollagen; Proline; Proteins; Uridine Diphosphate N-Acetylglucosamine | 1977 |
Factors affecting plasma amino acid concentrations in control subjects.
Topics: Adolescent; Adult; Aged; Amino Acids; Circadian Rhythm; Cystine; Dietary Proteins; Eating; Fasting; Female; Humans; Isoleucine; Leucine; Male; Methionine; Middle Aged; Proline; Sex Factors; Valine | 1979 |
Diurnal variations in plasma concentrations of tryptophan, tryosine, and other neutral amino acids: effect of dietary protein intake.
Topics: Adult; Alanine; Amino Acids; Circadian Rhythm; Dietary Proteins; Glycine; Humans; Isoleucine; Leucine; Male; Middle Aged; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1979 |
Diurnal variations in plasma neutral amino acid concentrations among patients with cirrhosis: effect of dietary protein.
Topics: Adult; Aged; Amino Acids; Circadian Rhythm; Dietary Proteins; Hepatic Encephalopathy; Humans; Isoleucine; Leucine; Liver Cirrhosis, Alcoholic; Male; Methionine; Middle Aged; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1979 |
Thin layer chromatographic analyses of amino acids in Echinostoma revolutum (Trematoda) adults.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Chromatography, Thin Layer; Echinostoma; Isoleucine; Leucine; Methionine; Proline; Serine; Tyrosine; Valine | 1977 |
Adaptive regulation of amino acid transport in cultured avian fibroblasts. Influence of the amino acid composition of the culture media.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Cells, Cultured; Culture Media; Cycloheximide; Leucine; Lysine; Proline | 1978 |
Effects of insulin in vivo and in vitro on amino acid transport into cells from the R3230AC mammary adenocarcinoma and their relationship to tumor growth.
Topics: Adenocarcinoma; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Insulin; Kinetics; Leucine; Mammary Neoplasms, Experimental; Proline; Rats; Sodium | 1978 |
Effects of calcitonin on epidermal regeneration and collagen synthesis in rabbits with experimental wounds.
Topics: Animals; Calcitonin; Collagen; Epidermis; Keratins; Leucine; Male; Proline; Rabbits; Regeneration; Thymidine; Uridine; Wound Healing | 1978 |
[Comparative studies of recombinant selection and linkage determinations with culture media prepared from anchovy].
Topics: Arabinose; Arginine; Chromosome Mapping; Culture Media; Escherichia coli; Fish Products; Genes; Genetic Linkage; Leucine; Mutation; Proline; Recombination, Genetic; Threonine | 1975 |
Amino acid starvation in Escherichia coli K-12: characteristics of the translation process.
Topics: Amino Acids; Bacterial Proteins; Coliphages; Escherichia coli; Histidine; Leucine; Peptide Biosynthesis; Peptide Chain Elongation, Translational; Proline; Protein Biosynthesis; Ribosomes; Viral Proteins | 1976 |
Mutagenesis in the strains E. coli K-12 with different ability to genetic recombination.
Topics: Alleles; Amino Acids; Arginine; Escherichia coli; Ethyl Methanesulfonate; Genes; Histidine; Leucine; Methylnitronitrosoguanidine; Mitomycins; Mutagens; Mutation; Proline; Recombination, Genetic; Threonine | 1976 |
An autoradiographic study of the projections of the mammillothalamic tract in the rat.
Topics: Animals; Autoradiography; Brain Mapping; Female; Leucine; Male; Mammillary Bodies; Neural Pathways; Proline; Rats; Thalamus | 1975 |
Notes on the application of radioactive amino acids for the tracing of neuronal connections.
Topics: Animals; Autoradiography; Basal Ganglia; Brain Mapping; Cats; Caudate Nucleus; Cerebellum; Cerebral Cortex; Haplorhini; Leucine; Neural Pathways; Proline; Putamen; Reticular Formation; Tegmentum Mesencephali; Tritium | 1975 |
Properties of Bacillus megaterium temperature-sensitive germination mutants.
Topics: Bacillus megaterium; Bromides; Drug Resistance, Microbial; Glucose; Leucine; Mutation; Picolinic Acids; Proline; Spores, Bacterial; Stereoisomerism; Streptomycin; Temperature; Tryptophan | 1975 |
Incomplete tricarboxylic acid cycle in a type I methylotroph, Methylococcus capsulatus.
Topics: Acetates; Arginine; Cell-Free System; Citric Acid Cycle; Glutamates; Ketoglutarate Dehydrogenase Complex; Leucine; Lipids; Methylococcaceae; Proline | 1975 |
Assimilation of citric acid and adipic acid by the blue-green alga Anabaena variabilis.
Topics: Adipates; Aspartic Acid; Chlorophyll; Citrates; Cyanobacteria; Darkness; Glutamates; Leucine; Light; Proline; Threonine | 1975 |
[Amino acid pattern in endemic (Balkan-)nephropathy (author's transl)].
Topics: Adolescent; Adult; Alanine; Amino Acids; Bulgaria; Child; Citrulline; Cystine; Disease Reservoirs; Female; Glycine; Humans; Isoleucine; Leucine; Male; Methionine; Nephritis, Interstitial; Ornithine; Phenylalanine; Proline; Romania; Serine; Yugoslavia | 1976 |
Synthesis of the glomerular basement membrane in the rat kidney. Autoradiographic studies with the light and electron microscope.
Topics: Animals; Autoradiography; Basement Membrane; Epithelial Cells; Kidney; Kidney Glomerulus; Leucine; Male; Microscopy, Electron; Proline; Rats; Tritium | 1976 |
The variability of human lambda-chain constant regions and some relationships to V-regions sequences.
Topics: Alanine; Amino Acid Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cystine; Electrophoresis, Paper; Glutamates; Glycine; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Isoleucine; Leucine; Peptides; Proline; Serine; Thiazoles; Threonine; Valine | 1976 |
Autoradiographic demonstration of a projection from prefrontal association cortex to the superior colliculus in the rhesus monkey.
Topics: Animals; Autoradiography; Cerebral Cortex; Haplorhini; Leucine; Macaca mulatta; Neural Pathways; Proline; Superior Colliculi | 1976 |
Variations in the concentrations of blood plasma free amino acids in suckled and fasted neonatal pigs.
Topics: Amino Acids; Animals; Animals, Newborn; Arginine; Cystine; Fasting; Glycine; Leucine; Lysine; Proline; Serine; Swine; Threonine; Tyrosine | 1977 |
Glomerular protein synthesis in proteinuric rats.
Topics: Amino Acids; Animals; Basement Membrane; Hydroxylation; Hydroxyproline; In Vitro Techniques; Kidney Glomerulus; Leucine; Male; Proline; Proteins; Proteinuria; Rats; Tyrosine | 1977 |
Cytologic and metabolic effects of prostaglandins on rat skin.
Topics: Animals; Autoradiography; Cell Nucleolus; Cell Nucleus; Collagen; Cytoplasm; Endoplasmic Reticulum; Fibroblasts; Injections, Intradermal; Injections, Intramuscular; Leucine; Male; Mitochondria; Proline; Prostaglandins E; Prostaglandins F; Rats; Skin; Thymidine; Uridine | 1977 |
Regulation of Protein Synthesis in Hen's oviducts. I. Removal of extracellular and intracellular proteins and their effects on protein synthesis.
Topics: Animals; Asparagine; Body Fluids; Chickens; Deoxycholic Acid; Egg Proteins; Extracellular Space; Female; Glycine; Intracellular Fluid; Leucine; Muramidase; Ovalbumin; Oviducts; Oviposition; Proline; Time Factors | 1977 |
On the derivatives for the ultramicrodetermination of amino acids by mass fragmentography.
Topics: Alanine; Amino Acids; Gas Chromatography-Mass Spectrometry; Glutamates; Indicators and Reagents; Leucine; Microchemistry; Proline; Valine | 1977 |
The nature of the amino acid pool used for protein synthesis in cultured, androgen-responsive tumour cells.
Topics: Amino Acids; Animals; Cell Line; Glycine; Intracellular Fluid; Kinetics; Leucine; Mammary Neoplasms, Experimental; Methionine; Mice; Proline; Protein Biosynthesis | 1977 |
Hemoglobin Mizuho or beta 68 (E 12) leucine leads to proline, a new unstable variant associated with severe hemolytic anemia.
Topics: Amino Acid Sequence; Anemia, Hemolytic; Child, Preschool; Female; Genetic Variation; Hemoglobins, Abnormal; Humans; Japan; Leucine; Peptides; Proline; Splenectomy | 1977 |
Muscle amino acid arylpeptidases and their serum changes with exercise.
Topics: Adolescent; Adult; Alanine; Aminopeptidases; Glycine; Humans; Leucine; Male; Muscles; Phenylalanine; Physical Exertion; Proline; Running; Skiing; Tyrosine | 1977 |
beta-structures of alternating polypeptides and their possible role in chemical evolution.
Topics: Circular Dichroism; Glycine; Leucine; Lysine; Peptides; Proline; Protein Conformation; Solubility; Stereoisomerism; Structure-Activity Relationship | 1977 |
Differential incorporation of tritiated proline and leucine by neurons of the dorsal column nuclei in the cat.
Topics: Animals; Axons; Cats; Female; Inferior Colliculi; Leucine; Male; Neurons; Olivary Nucleus; Proline; Spinal Cord | 1977 |
Ovalbumin synthesis in a homologous cell-free system prepared from hen's oviduct.
Topics: Adenosine Triphosphate; Animals; Cell-Free System; Chickens; Chromatography, Affinity; Dithiothreitol; Female; Kinetics; Leucine; Ovalbumin; Oviducts; Polyribosomes; Proline; Protein Biosynthesis | 1976 |
The X-Pro peptide bond as an nmr probe for conformational studies of flexible linear peptides.
Topics: Alanine; Binding Sites; Glycine; Leucine; Magnetic Resonance Spectroscopy; Molecular Conformation; Peptides; Phenylalanine; Proline; Stereoisomerism | 1976 |
Influence of D and L amino-acid residues on the conformation of peptides in solution: A carbon-13 nuclear magnetic resonance study of cyclo(prolyl-leucyl).
Topics: Amino Acid Sequence; Isomerism; Leucine; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Proline; Protein Conformation; Solutions; Stereoisomerism | 1976 |
Alterations in proline metabolic enzymes with mammalian development.
Topics: Aging; Animals; Carboxylic Acids; Female; Kidney; Kinetics; Leucine; Liver; Mitochondria, Liver; Organ Specificity; Oxidoreductases; Oxygenases; Pregnancy; Proline; Pyrroles; Rats; Stereoisomerism; Valine | 1976 |
Thalassemia intermedia caused by heterozygosity for both beta-thalassemia and hemoglobin Saki [beta 14 (A11) Leu replaced by Pro].
Topics: Adolescent; Hemoglobins; Heterozygote; Humans; Leucine; Male; Peptides; Proline; Thalassemia | 1976 |
Plasma amino acids in children and adolescents on hemodialysis.
Topics: Adolescent; Amino Acids; Child; Child Nutritional Physiological Phenomena; Citrulline; Diet; Female; Glycine; Growth; Histidine; Humans; Isoleucine; Leucine; Lysine; Male; Methylhistidines; Nutritional Physiological Phenomena; Proline; Renal Dialysis; Serine; Tyrosine; Valine | 1976 |
The metabolic effects of glucagon infusion in normoglycaemic and hypoglycaemic small-for-gestational-age infants. II. Changes in plasma amino acids.
Topics: Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Citrulline; Glucagon; Gluconeogenesis; Glycine; Humans; Hypoglycemia; Infant, Low Birth Weight; Infant, Newborn; Infant, Small for Gestational Age; Infusions, Parenteral; Isoleucine; Leucine; Liver; Proline; Valine | 1976 |
The accessory fibers of the sperm tail. High-sulfur and low-sulfur components in mammals and cephalopods.
Topics: Amino Acids; Animals; Aspartic Acid; Carbocysteine; Cattle; Electrophoresis, Polyacrylamide Gel; Glutamates; Humans; Leucine; Male; Molecular Weight; Mollusca; Octopodiformes; Proline; Proteins; Rats; Spectrophotometry, Infrared; Sperm Tail; Spermatozoa | 1976 |
Amino acid composition, distribution and origin of "tuft" protein in human and bovine dental enamel.
Topics: Alanine; Amelogenesis; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Dental Enamel; Dental Enamel Proteins; Glutamates; Glycine; Histidine; Humans; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1975 |
Transport properties of merodiploids covering the dagA locus in Escherichia coli K-12.
Topics: Alanine; Biological Transport, Active; Cell Membrane; Diploidy; Escherichia coli; Genes; Glycerol; Glycine; Kinetics; Leucine; Mutation; Proline; Serine; Stereoisomerism | 1975 |
Specialized peptide transport system in Escherichia coli.
Topics: Biological Transport, Active; Electrophoresis, Paper; Escherichia coli; Leucine; Lysine; Methionine; Mutation; Oligopeptides; Ornithine; Proline; Threonine; Valine | 1975 |
Transport of sugars and amino acids in bacteria. XIII. Mechanism of selective inhibition of the active transport reactions for proline, leucine, and succinate by zinc ions.
Topics: Biological Transport, Active; Chloromercuribenzoates; Escherichia coli; Fumarates; Glycerol; Lactates; Leucine; Magnesium; Oxygen Consumption; Proline; Succinate Dehydrogenase; Succinates; Zinc | 1975 |
Non-parallel transport of membrane proteins and content proteins during assembly of the secretory granule in rat parotid gland.
Topics: Amino Acids; Animals; Biological Transport; Cytoplasmic Granules; Leucine; Male; Membranes; Parotid Gland; Proline; Proteins; Rats | 1975 |
Projections from the retina to the lateral geniculate nucleus and mesencephalic tectum in a reptile (Tupinambis nigropunctatus): a comparison of anterograde transport and anterograde degeneration.
Topics: Animals; Autoradiography; Brain Mapping; Geniculate Bodies; Leucine; Lizards; Neural Pathways; Proline; Retina; Tectum Mesencephali; Tritium; Visual Pathways | 1975 |
A single-chain triple helical structure in synthetic polypeptides.
Topics: Amino Acid Sequence; Collagen; Glycine; Leucine; Peptides; Proline; Protein Conformation; X-Ray Diffraction | 1975 |
Incorporation of L-azetidine-2-carboxylic acid into hemoglobin in rabbit reticulocytes in vitro.
Topics: Amino Acids; Animals; Azetidines; Azetines; Carboxylic Acids; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Globins; Hemoglobins; Kinetics; Leucine; Lysine; Peptide Fragments; Proline; Rabbits; Reticulocytes; Time Factors; Trypsin | 1975 |
Distribution of radioactivity in the organs of the rat and mouse after injection of L-(3H)prolyl-L-leucyl-glycinamide.
Topics: Adipose Tissue; Adipose Tissue, Brown; Adrenal Glands; Animals; Cerebral Cortex; Epididymis; Glycine; Hippocampus; Hypothalamus; Injections, Intravenous; Intestinal Mucosa; Kidney; Leucine; Liver; Male; Oligopeptides; Pineal Gland; Pituitary Gland; Proline; Rats; Skin; Submandibular Gland; Testis; Tritium | 1975 |
Hemoglobin Atlanta or alpha 2 beta 2 75 Leu-Pro (E19): an unstable variant found in several members of a Caucasian family.
Topics: Alanine; Amino Acids; Female; Georgia; Heinz Bodies; Hemoglobins, Abnormal; Humans; Leucine; Peptide Fragments; Proline; Protein Conformation; White People | 1975 |
Sythesis of polypeptide models of collagen.
Topics: Chemical Fractionation; Collagen; Glycine; Leucine; Molecular Weight; Peptides; Phenylalanine; Proline; Sarcosine; Valine | 1975 |
Oxytocin analogs with substitutions in postions 3 and 4.
Topics: Alanine; Animals; Chickens; Leucine; Oxytocin; Proline; Rats | 1975 |
Some aspects of the organization of the thalamic reticular complex.
Topics: Animals; Autoradiography; Cats; Cerebral Cortex; Leucine; Macaca; Macaca mulatta; Peroxidases; Proline; Rats; Reticular Formation; Saimiri; Thalamus; Tritium | 1975 |
Observations on the lateral olfactory tract of the rat.
Topics: Animals; Autoradiography; Axons; Central Nervous System; Leucine; Male; Myelin Sheath; Nerve Fibers, Myelinated; Olfactory Bulb; Olfactory Pathways; Proline; Rats; Tritium | 1975 |
Conformational studies on sequential polypeptides. Part V. Synthesis and characterization of (Pro-Leu-Gly)10, (Pro-LeuqGly)n and (Leu-Pro-Gly)n.
Topics: Amino Acid Sequence; Collagen; Glycine; Leucine; Molecular Weight; Peptides; Proline; Protein Conformation | 1975 |
Significant differences in the degradation of pro-leu-gly-nH2 by human serum and that of other species (38484).
Topics: Aminopeptidases; Animals; Brain; Carps; Chickens; Female; Glycine; Humans; Hydrolysis; Leucine; Male; Oligopeptides; Oxytocin; Peptide Fragments; Peptide Hydrolases; Pregnancy; Proline; Rats | 1975 |
Amino acid reabsorption in the rat nephron. Free flow micropuncture study.
Topics: Absorption; Alanine; Amino Acids; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Glutamates; Glycine; Isoleucine; Kidney; Kidney Tubules, Proximal; Leucine; Lysine; Male; Nephrons; Phenylalanine; Proline; Rats; Taurine; Tyrosine | 1975 |
The uptake of endogenous proteins by oocyte nuclei.
Topics: Animals; Cell Nucleus; Cytoplasm; Female; Glucosamine; Glycoproteins; Kinetics; Leucine; Microinjections; Molecular Weight; Oocytes; Ovum; Peptides; Proline; Puromycin; Xenopus | 1975 |
Different targets of different neurons in nucleus gracilis of the cat.
Topics: Animals; Brain Mapping; Cats; Horseradish Peroxidase; Leucine; Medulla Oblongata; Neural Pathways; Olivary Nucleus; Proline; Thalamic Nuclei; Tritium | 1975 |
[Dipeptidase activity in the small intestine of patients with chronic nonspecific enteritis].
Topics: Adult; Alanine; Chronic Disease; Dipeptidases; Dipeptides; Enteritis; Female; Glutamates; Glycine; Humans; Intestine, Small; Isoleucine; Leucine; Male; Middle Aged; Proline; Valine | 1975 |
Effect of prostaglandins on protein, RNA, DNA and collagen synthesis in experimental wounds.
Topics: Animals; Collagen; DNA; Leucine; Male; Proline; Prostaglandins E; Prostaglandins F; Protein Biosynthesis; Rats; RNA; Stimulation, Chemical; Thymidine; Time Factors; Uridine; Wound Healing; Wounds and Injuries | 1975 |
Conformational studies on sequential polypeptides Part VI. Structural investigations on (Pro-Leu-Gly)10, (Pro-Leu-Gly)n and (Leu-Pro-Gly)n.
Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Circular Dichroism; Collagen; Glycine; Leucine; Peptides; Proline; Protein Conformation; Rats; X-Ray Diffraction | 1975 |
Compartmentalization of amino acids in surfactant aggregates. Partitioning between water and aqueous micellar sodium deodecanoate and between hexane and dodecylammonium propionate trapped water in hexane.
Topics: Alanine; Alkanes; Amino Acids; Arginine; Aspartic Acid; Colloids; Glutamates; Glycine; Isoleucine; Laurates; Leucine; Lysine; Micelles; Phenylalanine; Proline; Serine; Solubility; Threonine; Valine | 1975 |
Quantitative determinations by ion pair extraction. Part 12. Extraction of amino acids with quaternary ammonium ions.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Hydroxyproline; Ion Exchange; Leucine; Methionine; Phenylalanine; Proline; Quaternary Ammonium Compounds; Solutions; Tryptophan | 1975 |
[Free amino acids in the amniotic fluid and in maternal blood in advanced pregnancy].
Topics: Alanine; Amino Acids; Amniotic Fluid; Cysteine; Female; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Pregnancy Trimester, Third; Proline; Serine; Threonine; Tyrosine; Valine | 1975 |
A novel beta-globin structural mutant, Hb Brescia (beta 114 Leu-Pro), causing a severe beta-thalassemia intermedia phenotype.
Topics: Adolescent; Base Sequence; beta-Thalassemia; Erythrocytes; Female; Globins; Hemoglobins, Abnormal; Humans; Italy; Leucine; Macromolecular Substances; Male; Molecular Sequence Data; Proline | 1992 |
Mismatch PCR: a rapid method to screen for the Pro207-->Leu mutation in the lipoprotein lipase (LPL) gene.
Topics: Base Sequence; DNA, Single-Stranded; Genetic Testing; Humans; Leucine; Lipoprotein Lipase; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Proline | 1992 |
Functional consequences of alterations to Pro328 and Leu332 located in the 4th transmembrane segment of the alpha-subunit of the rat kidney Na+,K(+)-ATPase.
Topics: Animals; Base Sequence; Cell Line; Cell Membrane; Cloning, Molecular; DNA; Female; Kidney; Leucine; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; Ouabain; Proline; Protein Conformation; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 1992 |
Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0 (L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0.
Topics: Anti-Bacterial Agents; Antifungal Agents; Carbon Isotopes; Echinocandins; Glutamates; Glutamic Acid; Hydroxyproline; Leucine; Magnetic Resonance Spectroscopy; Mitosporic Fungi; Nitrogen Isotopes; Peptides; Peptides, Cyclic; Proline | 1992 |
A new PKU mutation associated with haplotype 12.
Topics: Amino Acid Sequence; Base Sequence; Chromosomes, Human, Pair 12; Exons; Female; Haplotypes; Humans; Leucine; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenylalanine Hydroxylase; Phenylketonurias; Point Mutation; Polymorphism, Restriction Fragment Length; Proline | 1992 |
An autoradiographic study of cortical projections from motor thalamic nuclei in the macaque monkey.
Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Cerebellum; Cerebral Cortex; Globus Pallidus; Leucine; Macaca; Proline; Stereotaxic Techniques; Thalamic Nuclei; Tritium | 1992 |
A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; DNA; DNA Probes; Heterozygote; Leucine; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Molecular Sequence Data; Molecular Weight; Mutation; Myelin Proteins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proline; Protein Conformation; Restriction Mapping; RNA | 1992 |
A leucine----proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis.
Topics: Amino Acid Sequence; Base Sequence; Humans; Ichthyosiform Erythroderma, Congenital; Intermediate Filaments; Keratins; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline | 1992 |
Pelizaeus-Merzbacher disease: detection of mutations Thr181----Pro and Leu223----Pro in the proteolipid protein gene, and prenatal diagnosis.
Topics: Amino Acid Sequence; Base Sequence; Chorionic Villi Sampling; Diffuse Cerebral Sclerosis of Schilder; DNA; Exons; Female; Genetic Counseling; Humans; Infant, Newborn; Leucine; Male; Molecular Sequence Data; Myelin Proteins; Myelin Proteolipid Protein; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Prenatal Diagnosis; Proline; Restriction Mapping; Threonine; X Chromosome | 1992 |
Identification and expression of a common missense mutation (L302P) in the acid sphingomyelinase gene of Ashkenazi Jewish type A Niemann-Pick disease patients.
Topics: Base Sequence; Cell Line; Codon; DNA; Gene Expression; Humans; Jews; Leucine; Molecular Sequence Data; Mutation; Niemann-Pick Diseases; Nucleic Acid Hybridization; Pedigree; Polymerase Chain Reaction; Proline; Sphingomyelin Phosphodiesterase; Transfection | 1992 |
Intestinal amino acid and monosaccharide transport in suckling pigs fed milk replacers with different sources of carbohydrate.
Topics: Aging; Amino Acids; Animals; Animals, Suckling; Biological Transport; Dietary Carbohydrates; Female; Food, Formulated; Fructose; Galactose; Glucose; Intestinal Absorption; Intestinal Mucosa; Lactose; Leucine; Male; Milk; Monosaccharides; Polysaccharides; Proline; Sucrose; Swine; Weight Gain | 1992 |
Structure and activity studies of pardaxin and analogues using model membranes of phosphatidylcholine.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Fish Venoms; Isoleucine; Leucine; Lipid Bilayers; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphatidylcholines; Proline; Protein Structure, Secondary; Solutions; Structure-Activity Relationship | 1992 |
An mRNA that specifically accumulates in maize roots delineates a novel subset of developing cortical cells.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Gene Library; Genes; In Situ Hybridization; Leucine; Light-Harvesting Protein Complexes; Molecular Sequence Data; Photosynthetic Reaction Center Complex Proteins; Plant Proteins; Proline; Protein Conformation; RNA, Messenger; Zea mays | 1992 |
Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PIA1) and HPA-1b (Zwb/PIA2).
Topics: Antigens, Human Platelet; Blood Platelets; Histocompatibility Testing; HLA-DR Antigens; HLA-DR Serological Subtypes; Humans; Integrin beta3; Isoantibodies; Leucine; Membrane Glycoproteins; Phenotype; Proline | 1992 |
Diffuse loss of rod function in autosomal dominant retinitis pigmentosa with pro-347-leu mutation of rhodopsin.
Topics: Adult; Aged; Dark Adaptation; DNA Mutational Analysis; Electroretinography; Female; Fundus Oculi; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Photoreceptor Cells; Proline; Retinal Diseases; Retinitis Pigmentosa; Rhodopsin; Visual Fields | 1992 |
A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level.
Topics: Anemia, Hemolytic; Base Sequence; Blotting, Southern; Chromosome Deletion; Codon; DNA; Female; Globins; Hemoglobins, Abnormal; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Proline; RNA, Messenger | 1992 |
Antithrombin III Budapest: a single amino acid substitution (429Pro to Leu) in a region highly conserved in the serpin family.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antithrombin III; Base Sequence; DNA; Heparin; Homozygote; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Proline; Thrombin; Thromboembolism | 1992 |
Rhodamine B inhibits collagen synthesis by human lip fibroblasts in culture.
Topics: Cell Count; Cells, Cultured; Collagen; Cosmetics; DNA; Dose-Response Relationship, Drug; Extracellular Matrix; Humans; L-Lactate Dehydrogenase; Leucine; Lip; Proline; Rhodamines; Thymidine | 1992 |
Differential helix propensity of small apolar side chains studied by molecular dynamics simulations.
Topics: Alanine; Amino Acids; Aminobutyrates; Glycine; Hydrogen Bonding; Leucine; Peptides; Proline; Protein Conformation; Structure-Activity Relationship; Thermodynamics; Valine | 1992 |
Amino acid incorporation in cell cultures from eyes with pseudo-exfoliation material.
Topics: Anterior Eye Segment; Cells, Cultured; Conjunctival Diseases; Extracellular Matrix; Eye Diseases; Humans; Leucine; Proline | 1992 |
Spontaneous neurodegeneration in transgenic mice with prion protein codon 101 proline----leucine substitution.
Topics: Amino Acid Sequence; Animals; Brain; Codon; Gene Expression; Gerstmann-Straussler-Scheinker Disease; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Prions; Proline; PrPSc Proteins | 1991 |
A simple ordering of neocortical areas established by the compartmental organization of their striatal projections.
Topics: Animals; Autoradiography; Axonal Transport; Cats; Cerebral Cortex; Corpus Striatum; Leucine; Methionine; Proline; Tritium | 1990 |
Visual corticopontine and tectopontine projections in the macaque.
Topics: Animals; Autoradiography; Evoked Potentials; Histocytochemistry; Horseradish Peroxidase; Leucine; Macaca fascicularis; Occipital Lobe; Pons; Proline; Staining and Labeling; Superior Colliculi; Visual Cortex; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1990 |
A 13-mer peptide straddling the leucine33/proline33 polymorphism in glycoprotein IIIa does not define the PLA1 epitope.
Topics: Amino Acid Sequence; Antigens, Human Platelet; Deoxyribonucleases, Type II Site-Specific; DNA; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoblotting; Integrin beta3; Isoantigens; Leucine; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Proline; Protein Conformation; Subtilisins | 1991 |
[Molecular genetic analysis of neurologic diseases].
Topics: Amino Acid Sequence; Base Sequence; Epilepsies, Myoclonic; Gaucher Disease; Glucosylceramidase; Homozygote; Humans; Leucine; Molecular Sequence Data; Mutation; Proline; RNA; RNA, Mitochondrial; RNA, Transfer, Lys | 1990 |
Compartmental organization of the thalamostriatal connection in the cat.
Topics: Animals; Autoradiography; Axonal Transport; Cats; Caudate Nucleus; Corpus Striatum; Leucine; Nerve Fibers; Proline; Putamen; Thalamus; Tritium | 1991 |
Connectional studies of the primate lateral geniculate nucleus: distribution of axons arising from the thalamic reticular nucleus of Galago crassicaudatus.
Topics: Animals; Autoradiography; Axonal Transport; Axons; Dendrites; Galago; Geniculate Bodies; Leucine; Microscopy, Electron; Proline; Thalamic Nuclei; Tritium | 1991 |
Proline metabolism in adult male burned patients and healthy control subjects.
Topics: Adult; Burns; Carbon Isotopes; Deuterium; Humans; Kinetics; Leucine; Male; Oxidation-Reduction; Proline | 1991 |
Identification of the 664 proline to leucine mutation in the low density lipoprotein receptor in four unrelated patients with familial hypercholesterolaemia in the UK.
Topics: Adolescent; Adult; Base Sequence; Codon; Female; Genetic Carrier Screening; Haplotypes; Humans; Hyperlipoproteinemia Type II; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Receptors, LDL; United Kingdom | 1991 |
Molecular and endocrine characterization of a mutation involving a recombination between the steroid 21-hydroxylase functional gene and pseudogene.
Topics: Adrenal Hyperplasia, Congenital; Amino Acid Sequence; Base Sequence; DNA; Female; Genes, MHC Class II; HLA-B Antigens; HLA-B44 Antigen; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Polymerase Chain Reaction; Proline; Pseudogenes; Recombination, Genetic; Steroid 21-Hydroxylase | 1991 |
Gaucher disease: heterologous expression of two alleles associated with neuronopathic phenotypes.
Topics: Acute Disease; Alleles; Animals; Arginine; Baculoviridae; beta-Glucosidase; Cell Line; Cells, Cultured; Gaucher Disease; Gene Expression; Humans; Immunoblotting; Insecta; Leucine; Lysosomes; Mutagenesis, Site-Directed; Phenotype; Proline | 1991 |
Analysis of neutral amino acid transport systems in the small intestine: a study of brush border membrane vesicles.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Culture Media; Cysteine; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Microvilli; Proline; Serine | 1991 |
Secondary structure and side-chain 1H and 13C resonance assignments of calmodulin in solution by heteronuclear multidimensional NMR spectroscopy.
Topics: Alanine; Amino Acid Sequence; Amino Acids, Branched-Chain; Amino Acids, Diamino; Amino Acids, Dicarboxylic; Animals; Asparagine; Binding Sites; Calcium; Calmodulin; Drosophila melanogaster; Glutamine; Glycine; Hydrogen Bonding; Leucine; Magnetic Resonance Spectroscopy; Methionine; Molecular Sequence Data; Molecular Structure; Proline; Recombinant Proteins; Serine; Solutions; Threonine | 1991 |
Dual mode of corticothalamic synaptic termination in the mediodorsal nucleus of the rhesus monkey.
Topics: Animals; Autoradiography; Axons; Cerebral Cortex; Dendrites; Leucine; Macaca mulatta; Microscopy, Electron; Proline; Synapses; Thalamus; Tritium | 1991 |
A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Gene Expression; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Kinetics; Leucine; Mutation; Phosphorylation; Proline; Protein Precursors; Receptor, Insulin; Transfection | 1991 |
Fibrinogen Kanazawa: a congenital dysfibrinogenaemia with delayed polymerization having a replacement of proline-18 by leucine in the A alpha-chain.
Topics: Adult; Amino Acid Sequence; Blood Coagulation Disorders; Blood Coagulation Tests; Female; Fibrinogens, Abnormal; Fibrinopeptide A; Fibrinopeptide B; Humans; Leucine; Molecular Sequence Data; Polymers; Proline | 1991 |
Non-existence of a tight association between a 444leucine to proline mutation and phenotypes of Gaucher disease: high frequency of a NciI polymorphism in the non-neuronopathic form.
Topics: Deoxyribonucleases, Type II Site-Specific; Female; Gaucher Disease; Humans; Leucine; Male; Mutation; Pedigree; Phenotype; Polymorphism, Restriction Fragment Length; Proline | 1990 |
Molecular sizes of amino acid transporters in the luminal membrane from the kidney cortex, estimated by the radiation-inactivation method.
Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Animals; Benzoates; Benzoic Acid; Biological Transport; Carrier Proteins; Cell Membrane Permeability; Dose-Response Relationship, Radiation; Free Radicals; Gamma Rays; Glutamates; Glutamic Acid; Kidney Cortex; Kinetics; Leucine; Microvilli; Proline; Rats; Sodium | 1990 |
Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg.
Topics: Amino Acid Sequence; Aminoglutethimide; Androstenedione; Animals; Arginine; Aromatase; Base Sequence; Cell Line; Humans; Kinetics; Leucine; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phenylalanine; Proline; Substrate Specificity; Testosterone; Transfection; Tyrosine | 1991 |
Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3.
Topics: Adenine; Anemia, Hemolytic; Base Sequence; Cytosine; DNA; Exons; Female; Guanine; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Phosphoglycerate Kinase; Proline; Thymine | 1991 |
Ocular findings in patients with autosomal dominant retinitis pigmentosa and rhodopsin, proline-347-leucine.
Topics: Adolescent; Adult; Amino Acid Sequence; Chromosome Aberrations; Chromosome Disorders; Dark Adaptation; Electroretinography; Female; Fundus Oculi; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Night Blindness; Pedigree; Proline; Retinitis Pigmentosa; Rhodopsin; Visual Fields | 1991 |
Influence of high glucose concentrations on glycosaminoglycan and collagen synthesis in cultured human gingival fibroblasts.
Topics: Adult; Cell Count; Cells, Cultured; Collagen; Connective Tissue; Connective Tissue Cells; Fibroblasts; Gingiva; Glucosamine; Glucose; Glycopeptides; Glycosaminoglycans; Humans; Hyaluronic Acid; Leucine; Proline; Tritium | 1991 |
Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.
Topics: Adult; Amino Acid Sequence; Chromatography, High Pressure Liquid; Congenital Abnormalities; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogens, Abnormal; Genetic Variation; Humans; Leucine; Molecular Sequence Data; Proline | 1991 |
A mutation (Pro-30 to Leu) in CYP21 represents a potential nonclassic steroid 21-hydroxylase deficiency allele.
Topics: Adrenal Hyperplasia, Congenital; Alleles; Animals; Base Sequence; Female; Humans; Leucine; Male; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Pedigree; Proline; Rabbits; Recombinant Proteins; Steroid 21-Hydroxylase; Vaccinia virus | 1991 |
Chloride-dependence of amino acid transport in rabbit ileum.
Topics: Amino Acids; Animals; beta-Alanine; Chlorides; Female; Glucose; Ileum; Jejunum; Leucine; Proline; Rabbits; Sodium | 1990 |
Amino acid substitutions Phe66----Leu and Ser126----Pro abolish cortisol and aldosterone synthesis by bovine cytochrome P450(11)beta.
Topics: Adrenal Cortex; Aldosterone; Animals; Base Sequence; Cattle; Cell Line; Cloning, Molecular; Codon; Desoxycorticosterone; DNA; Hydrocortisone; Leucine; Mitochondria; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phenylalanine; Plasmids; Polymerase Chain Reaction; Proline; RNA, Messenger; Serine; Steroid 11-beta-Hydroxylase; Transfection | 1990 |
Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect.
Topics: Adult; Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Codon; DNA; DNA Restriction Enzymes; Exons; Family; Gene Amplification; Genes; Humans; Hypoproteinemia; Leucine; Male; Molecular Sequence Data; Proline; Promoter Regions, Genetic; Racial Groups; Thyronines; Thyroxine-Binding Proteins | 1990 |
Cloning of genes required for amino acid biosynthesis from Leptospira interrogans serovar icterohaemorrhagiae.
Topics: Amino Acids; Bacterial Typing Techniques; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genetic Complementation Test; Leptospira interrogans; Leucine; Mutation; Nucleic Acid Hybridization; Proline; Restriction Mapping | 1990 |
Analysis of lens protein synthesis in a cataractous mutant mouse: the Cat Fraser.
Topics: Animals; Cataract; Collagen; Crystallins; Epithelium; Hydroxyproline; Lens Capsule, Crystalline; Lens, Crystalline; Leucine; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Proline | 1990 |
Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica.
Topics: Cell Count; Cell Survival; Cells, Cultured; Collagen; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Hydroxyproline; Leucine; Male; Pentacyclic Triterpenes; Procollagen; Proline; RNA, Transfer, Pro; Terpenes; Triterpenes | 1990 |
Plasma proline kinetics and concentrations in young men in response to dietary proline deprivation.
Topics: Adult; Amino Acids; Analysis of Variance; Dietary Proteins; Humans; Kinetics; Leucine; Male; Oxidation-Reduction; Proline | 1990 |
A double-isotope procedure for examining protein microheterogeneity: multiple forms of fast-transported glycoproteins and sulfoproteins possess a common polypeptide chain.
Topics: Animals; Axonal Transport; Biological Transport, Active; Electrophoresis, Polyacrylamide Gel; Ganglia, Spinal; Glycoproteins; Isoelectric Focusing; Leucine; Methionine; Methods; Proline; Proteins; Rana catesbeiana; Sulfuric Acids | 1986 |
Telencephalic projections from midbrain and isthmal cell groups in the pigeon. I. Locus coeruleus and subcoeruleus.
Topics: Animals; Autoradiography; Axonal Transport; Brain Mapping; Brain Stem; Cerebellum; Columbidae; Efferent Pathways; Female; Horseradish Peroxidase; Leucine; Limbic System; Locus Coeruleus; Male; Nucleus Accumbens; Proline; Species Specificity; Spinal Cord; Telencephalon | 1986 |
A glial-neuronal-glial communication system in the mammalian central nervous system.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Autoradiography; Axonal Transport; Axons; Brain; Cats; Cell Communication; Female; Leucine; Male; Medulla Oblongata; Microscopy, Electron; Neuroglia; Neurons; Proline; Spinal Cord | 1987 |
The disturbance of the fast axonal transport of protein by passive stretching of an axon in Aplysia.
Topics: Animals; Aplysia; Axonal Transport; Axons; Cells, Cultured; Leucine; Proline; Proteins; Stress, Mechanical | 1987 |
Vestibular projections to the thalamus of the pigeon: an anatomical study.
Topics: Animals; Autoradiography; Brain Mapping; Columbidae; Horseradish Peroxidase; Leucine; Proline; Thalamus; Vestibular Nuclei; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1988 |
Mediodorsal nucleus: areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys.
Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Cerebral Cortex; Efferent Pathways; Female; Horseradish Peroxidase; Leucine; Macaca; Macaca mulatta; Male; Proline; Thalamus; Tritium; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1988 |
A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.
Topics: Cells, Cultured; Cloning, Molecular; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; Fibroblasts; Genotype; Humans; Insulin Resistance; Leucine; Male; Mutation; Pedigree; Proline; Radioligand Assay; Receptor, Insulin | 1989 |
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Neprilysin; Pain; Proline; Protease Inhibitors; Thiohydantoins; Thiorphan | 1989 |
At least two mutant alleles of ornithine delta-aminotransferase cause gyrate atrophy of the choroid and retina in Finns.
Topics: Alleles; Arginine; Atrophy; Choroid; DNA; Female; Finland; Genes; Humans; Leucine; Male; Mutation; Ornithine-Oxo-Acid Transaminase; Pedigree; Proline; Retina; Retinal Degeneration; Threonine; Transaminases; Uveal Diseases | 1989 |
Comparison of trigeminal receptor location and structure in the periodontal ligament of different types of teeth from the rat, cat, and monkey.
Topics: Animals; Autoradiography; Cats; Haplorhini; Incisor; Leucine; Mechanoreceptors; Periodontal Ligament; Proline; Rats; Tooth; Trigeminal Nerve | 1989 |
The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.
Topics: Amino Acid Sequence; Antigens, Human Platelet; Base Sequence; DNA; Homozygote; Humans; Integrin beta3; Isoantigens; Leucine; Phenotype; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline | 1989 |
Substitution of amino acids in helix F of bacteriorhodopsin: effects on the photochemical cycle.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Bacteriorhodopsins; Glutamates; Glutamic Acid; Glutamine; Glycine; Hydrogen Bonding; Kinetics; Leucine; Molecular Sequence Data; Mutation; Phenylalanine; Photochemistry; Proline; Protons; Serine; Tryptophan | 1989 |
NMR studies of Arc repressor mutants: proton assignments, secondary structure, and long-range contacts for the thermostable proline-8----leucine variant of Arc.
Topics: Amino Acid Sequence; Electronic Data Processing; Leucine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Proline; Protein Conformation; Repressor Proteins; Salmonella Phages; Transcription Factors; Viral Proteins; Viral Regulatory and Accessory Proteins | 1989 |
Retinal projection to mammalian telencephalon.
Topics: Animals; Autoradiography; Hypothalamus; Leucine; Mammals; Optic Nerve; Proline; Retina; Species Specificity; Telencephalon; Tritium; Visual Pathways | 1989 |
The differentiation of normal and transformed human fibroblasts in vitro is influenced by electromagnetic fields.
Topics: Cell Differentiation; Cell Line; Collagen; Electromagnetic Fields; Electromagnetic Phenomena; Fibroblasts; Humans; Leucine; Lung; Mitosis; Proline; Protein Biosynthesis; Proteins; Skin | 1989 |
Pro----leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome.
Topics: Alleles; DNA; Ethnicity; Genes, Viral; Humans; Leucine; Mutation; Nucleic Acid Hybridization; Polymorphism, Genetic; Prions; Proline; Slow Virus Diseases; Viral Proteins | 1989 |
A Pro----Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI MHeerlen.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Blotting, Southern; Codon; DNA; Exons; Female; Humans; Leucine; Male; Mutation; Pedigree; Phenotype; Proline; RNA, Messenger | 1989 |
Hemoglobin Nouakchott [alpha 114(GH2)Pro----Leu]: a new hemoglobin variant displaying an unusual increase in hydrophobicity.
Topics: Adult; Amino Acid Sequence; Binding Sites; Electrophoresis; Female; Hemoglobins, Abnormal; Humans; Isoelectric Focusing; Leucine; Male; Middle Aged; Molecular Sequence Data; Oxygen; Peptides; Proline | 1989 |
Thalamocortical connections of the rostral intralaminar nuclei: an autoradiographic analysis in the cat.
Topics: Animals; Autoradiography; Cats; Cerebral Cortex; Leucine; Neural Pathways; Proline; Thalamic Nuclei | 1989 |
Distribution of corticotectal axons from the caudal part of the anterior ectosylvian sulcus in the cat.
Topics: Animals; Axons; Brain Mapping; Cats; Cerebral Cortex; Leucine; Proline; Superior Colliculi | 1989 |
A novel globin structural mutant, Showa-Yakushiji (beta 110 Leu-Pro) causing a beta-thalassemia phenotype.
Topics: Amino Acid Sequence; Base Sequence; DNA Restriction Enzymes; Genes; Globins; Humans; Leucine; Mutation; Phenotype; Proline; Thalassemia | 1987 |
Role of codon choice in the leader region of the ilvGMEDA operon of Serratia marcescens.
Topics: Base Sequence; Codon; DNA Restriction Enzymes; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Leucine; Mutation; Operon; Plasmids; Proline; RNA, Messenger; Serratia marcescens; Transcription, Genetic | 1987 |
Some extra-striate corticothalamic connections in macaque monkeys.
Topics: Animals; Cerebral Cortex; Leucine; Macaca; Macaca fascicularis; Proline; Synaptic Transmission; Thalamus; Visual Pathways | 1988 |
Effect of parathyroid hormone on amino acid transport by cultured neonatal mouse calvarial bone cells.
Topics: Animals; Animals, Newborn; Biological Transport; Bucladesine; Cells, Cultured; Cycloheximide; Dactinomycin; Kinetics; Leucine; Mice; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Proline; Teriparatide | 1988 |
Modulation of amino acid and 2-oxo acid pools in Trichomonas vaginalis by aspartate aminotransferase inhibitors.
Topics: Alanine; Amino Acids; Amino Acids, Dicarboxylic; Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Culture Media; Glutamates; Glutamic Acid; Hydroxamic Acids; Leucine; Proline; Trichomonas vaginalis | 1986 |
Comparison of the use of isotopic proline vs leucine to measure protein synthesis in cultured fibroblasts.
Topics: Carbon Radioisotopes; Cell Line; Collagen; Culture Media; Embryo, Mammalian; Fibroblasts; Humans; Leucine; Proline; Protein Biosynthesis; RNA, Transfer, Amino Acyl; Tritium | 1986 |
The effect of the intracellular sodium level on the activity of amino acid transport systems L and A in SV40 3T3 cells.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Cell Transformation, Viral; Cells, Cultured; Kinetics; Leucine; Lithium; Methylglucosides; Mice; Phenylalanine; Proline; Simian virus 40; Sodium | 1985 |
Effects of the putative neutrophil-generated toxin, hypochlorous acid, on membrane permeability and transport systems of Escherichia coli.
Topics: beta-Galactosidase; Cell Membrane Permeability; Chloramines; Escherichia coli; Glutamine; Hypochlorous Acid; Leucine; Methylgalactosides; Neutrophils; Proline; Thiogalactosides; Toxins, Biological | 1986 |
Cloning in Escherichia coli of genes involved in the synthesis of proline and leucine in Desulfovibrio desulfuricans Norway.
Topics: Cloning, Molecular; Desulfovibrio; DNA Restriction Enzymes; Escherichia coli; Genes; Genes, Viral; Genetic Vectors; Leucine; Plasmids; Proline | 1987 |
Antithrombin III Basel. Identification of a Pro-Leu substitution in a hereditary abnormal antithrombin with impaired heparin cofactor activity.
Topics: Amino Acid Sequence; Antithrombin III; Chromatography, High Pressure Liquid; Humans; Isothiocyanates; Leucine; p-Dimethylaminoazobenzene; Peptide Fragments; Proline; Structure-Activity Relationship; Thiocyanates; Thiohydantoins; Trypsin | 1986 |
Echinococcus granulosus: absorption of cycloleucine and alpha-aminoisobutyric acid by protoscoleces.
Topics: Absorption; Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cycloleucine; Diffusion; Echinococcus; Hydrogen-Ion Concentration; Leucine; Methionine; Proline; Serine; Valine | 1986 |
Uptake pathways for amino acids in mouse intestine.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Intestinal Absorption; Jejunum; Kinetics; Leucine; Lysine; Male; Methionine; Mice; Proline; Sodium | 1986 |
Further studies on the nutritional factors affecting the urinary excretion of acid-soluble peptides in rats.
Topics: Aging; Amino Acids; Animals; Caseins; Dietary Proteins; Leucine; Lysine; Male; Methylhistidines; Nitrogen; Peptides; Proline; Rats; Rats, Inbred Strains; Tryptophan; Valine | 1988 |
A topographic study of the course of nigral axons and of the distribution of pallidal axonal endings in the centre médian-parafascicular complex of macaques.
Topics: Animals; Autoradiography; Brain Mapping; Globus Pallidus; Leucine; Macaca; Nerve Endings; Neural Pathways; Proline; Substantia Nigra; Thalamic Nuclei | 1988 |
Corticonigral projections from area 6 in the raccoon.
Topics: Animals; Autoradiography; Brain Mapping; Cerebral Cortex; Leucine; Neural Pathways; Proline; Raccoons; Substantia Nigra | 1988 |
A functional interaction between the signal peptide and the translation apparatus is detected by the use of a single point mutation which blocks translocation across mammalian endoplasmic reticulum.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Endopeptidases; Endoplasmic Reticulum; Escherichia coli; Leucine; Membrane Proteins; Mutation; Plasmids; Proline; Protein Biosynthesis; Protein Sorting Signals; Serine Endopeptidases; Structure-Activity Relationship; Transcription, Genetic | 1987 |
Retinal projections to the pretectum in the pigeon (Columba livia).
Topics: Animals; Autoradiography; Brain Mapping; Columbidae; Eye; Female; Injections; Leucine; Male; Proline; Retina; Retinal Ganglion Cells; Superior Colliculi; Visual Pathways | 1988 |
Corticothalamic connections of paralimbic regions in the rhesus monkey.
Topics: Animals; Autoradiography; Brain Mapping; Cerebral Cortex; Leucine; Macaca; Macaca mulatta; Neural Pathways; Proline; Thalamus | 1988 |
Nonretinal projections to the medial terminal accessory optic nucleus in rabbit and rat: a retrograde and anterograde transport study.
Topics: Animals; Autoradiography; Brain Mapping; Horseradish Peroxidase; Leucine; Mesencephalon; Neural Pathways; Periaqueductal Gray; Proline; Rabbits; Rats; Superior Colliculi; Visual Pathways | 1988 |
Bilateral pericruciate cortical innervation of the red nucleus in cats with adult or neonatal cerebral hemispherectomy.
Topics: Aging; Animals; Autoradiography; Cats; Cerebral Cortex; Cerebral Decortication; Female; Leucine; Male; Neural Pathways; Neuronal Plasticity; Proline; Red Nucleus | 1988 |
Direct functional assessment of human osteoblasts by radioautography: methodology and application in end stage renal disease.
Topics: Aluminum; Autoradiography; Biopsy; Bone and Bones; Cycloheximide; Female; Humans; Kidney Failure, Chronic; Leucine; Male; Middle Aged; Osteoblasts; Proline; Protein Biosynthesis; Reference Values; Tetracycline; Tritium | 1988 |
Effects of prostaglandin E1 on collagen production and degradation in human fetal lung fibroblasts.
Topics: Alprostadil; Cell Line; Collagen; Fetus; Glycine; Humans; Hydroxyproline; Intracellular Membranes; Leucine; Lung; Proline | 1988 |
The effect of prostaglandin E2 (PGE2) on amino acid uptake and protein formation by lung fibroblasts.
Topics: Amino Acids; Aminoisobutyric Acids; Biological Transport; Cell Line; Dinoprostone; Fibroblasts; Humans; Kinetics; Leucine; Lung; Proline; Prostaglandins E; Protein Biosynthesis | 1986 |
Differences in the efficiency and pattern of incorporation of [3H]leucine and [3H]proline into proteins of adult cat brain.
Topics: Animals; Autoradiography; Cats; Cell Membrane Permeability; Female; Leucine; Male; Medulla Oblongata; Molecular Weight; Nerve Tissue Proteins; Neuroglia; Neurons; Proline | 1987 |
Autoradiographic study of the distribution of [3H]gamma-aminobutyrate-accumulating neural elements in guinea-pig intestine: evidence for a transmitter function of gamma-aminobutyrate.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Aminobutyrates; Animals; Autoradiography; Colon; Cyclohexanecarboxylic Acids; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; Leucine; Male; Myenteric Plexus; Neurons; Nipecotic Acids; Paraffin; Proline | 1986 |
Posterior parietal projections to the intraparietal sulcus of the rhesus monkey.
Topics: Animals; Brain Mapping; Leucine; Macaca mulatta; Microinjections; Neural Pathways; Parietal Lobe; Proline | 1986 |
The effects of neonatal monocular enucleation on the organization of ipsilateral and contralateral retinothalamic projections in the rabbit.
Topics: Animals; Animals, Newborn; Autoradiography; Functional Laterality; Leucine; Neurons; Proline; Rabbits; Retina; Sensory Deprivation; Thalamus | 1986 |
Amino acid catabolism in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus. 2. Metabolism of the carbon skeleton.
Topics: Amino Acids; Animals; Heligmosomatoidea; Isoleucine; Leucine; Liver; Nematoda; Nematospiroides dubius; Proline; Rats; Valine | 1986 |
Comparison of olfactory bulb projections in pigeons and turtles.
Topics: Animals; Autoradiography; Brain Mapping; Central Nervous System; Columbidae; Leucine; Olfactory Bulb; Olfactory Pathways; Proline; Species Specificity; Telencephalon; Turtles | 1985 |
Mechanistic implications of the inhibition of peptidases by amino aldehydes and bestatin.
Topics: Alanine; Aldehydes; Aminopeptidases; Animals; Aspartic Acid Endopeptidases; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Kidney; Kinetics; Leucine; Leucyl Aminopeptidase; Male; Peptide Hydrolases; Proline; Protease Inhibitors; Rats; Testis | 1985 |
Projections from the ventral respiratory group to phrenic and intercostal motoneurons in cat: an autoradiographic study.
Topics: Animals; Autoradiography; Axons; Biological Transport, Active; Cats; Intercostal Nerves; Leucine; Lysine; Motor Neurons; Phrenic Nerve; Proline; Respiration; Spinal Cord; Thoracic Nerves | 1985 |
Mechanical stretching increases the number of cultured bone cells synthesizing DNA and alters their pattern of protein synthesis.
Topics: Animals; Animals, Newborn; Bone and Bones; Cells, Cultured; Collagen; DNA; DNA Replication; Leucine; Proline; Proteins; Rats; Stress, Mechanical; Thymidine; Tritium | 1985 |
Is intestinal transport of sugars and amino acids subject to critical-period programming?
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Body Weight; Carbohydrate Metabolism; Diet; Female; Glucose; Humans; Intestinal Mucosa; Intestine, Small; Intestines; Leucine; Lysine; Male; Mice; Potassium; Pregnancy; Proline | 1985 |
Topography of occipital lobe commissural connections in the rhesus monkey.
Topics: Animals; Autoradiography; Corpus Callosum; Leucine; Macaca mulatta; Occipital Lobe; Proline; Visual Cortex; Visual Fields | 1986 |
Kinetics of inhibition of rat liver and kidney arginases by proline and branched-chain amino acids.
Topics: Amino Acids, Branched-Chain; Animals; Arginase; Isoleucine; Kidney; Kinetics; Leucine; Liver; Proline; Rats; Valine | 1986 |
An EM-autoradiographic and EM-HRP study of the commissural projection of the superior colliculus in the cat.
Topics: Animals; Autoradiography; Cats; Horseradish Peroxidase; Leucine; Microscopy, Electron; Proline; Superior Colliculi; Synapses; Visual Pathways | 1985 |
Stimulation of rat uterine collagen synthesis by relaxin.
Topics: Animals; Carbon Radioisotopes; Castration; Collagen; Diaphragm; Female; Kinetics; Leucine; Muscle, Smooth; Organ Size; Organ Specificity; Proline; Rats; Rats, Inbred Strains; Relaxin; Tritium; Uterus | 1985 |
Increased dependence of leucine in posttraumatic sepsis: leucine/tyrosine clearance ratio as an indicator of hepatic impairment in septic multiple organ failure syndrome.
Topics: Adolescent; Adult; Alanine; Amino Acids; Amino Acids, Essential; Aspartic Acid; Glutamates; Humans; Leucine; Liver; Metabolic Clearance Rate; Multiple Organ Failure; Muscles; Proline; Sepsis; Tyrosine; Wounds and Injuries | 1985 |
Quantitative analyses of axonal endings in the central nucleus of the inferior colliculus and distribution of 3H-labeling after injections in the dorsal cochlear nucleus.
Topics: Animals; Axons; Biological Transport; Cats; Cochlear Nerve; Inferior Colliculi; Injections; Leucine; Microscopy, Electron; Proline; Synaptic Vesicles; Tissue Distribution; Tritium | 1985 |
The thalamic relations of the caudal inferior parietal lobule and the lateral prefrontal cortex in monkeys: divergent cortical projections from cell clusters in the medial pulvinar nucleus.
Topics: Animals; Autoradiography; Fluorescent Dyes; Frontal Lobe; Leucine; Macaca fascicularis; Neural Pathways; Parietal Lobe; Proline; Superior Colliculi; Thalamic Nuclei | 1985 |
[Biosynthetic actinomycins from aurantin-producing Actynomyces].
Topics: Actinomyces; Amino Acids; Antibiotics, Antineoplastic; Chromatography; Culture Media; Dactinomycin; Flavonoids; Isoleucine; Leucine; Oxidation-Reduction; Proline; Sarcosine; Threonine; Valine | 1971 |
Components of fast and slow axonal transport in the goldfish optic nerve.
Topics: Animals; Axonal Transport; Biological Transport, Active; Colchicine; Cyprinidae; Fucose; Glucosamine; Leucine; Nerve Tissue Proteins; Optic Nerve; Proline; Tectum Mesencephali; Tritium | 1971 |
Effects of a nicotinamide-sensitive teratogen 6-aminonicotinamide on chick limb cells in culture.
Topics: Abnormalities, Drug-Induced; Amines; Animals; Bone and Bones; Carbon Isotopes; Cartilage; Cells, Cultured; Chick Embryo; Culture Techniques; Ketones; Leucine; Mesoderm; Niacinamide; Proline; Pyridines; Staining and Labeling; Sulfates; Sulfur Isotopes; Thymidine; Tritium; Wings, Animal | 1972 |
Neuroplasmic transport in the nervous system of the cockroach Periplaneta americana.
Topics: Animals; Axonal Transport; Carbon Isotopes; Cockroaches; Cycloheximide; Ganglia; Leucine; Lysine; Microtubules; Models, Neurological; Nerve Tissue Proteins; Proline; Puromycin; Thymidine; Tritium; Uridine; Valine | 1971 |
Transfer of material from efferent axons to sensory epithelium in the goldfish vestibular system.
Topics: Amino Acids; Animals; Arginine; Autoradiography; Axonal Transport; Cyprinidae; Epithelial Cells; Epithelium; Leucine; Lysine; Medulla Oblongata; Neurons, Efferent; Proline; Silver; Staining and Labeling; Tritium; Valine; Vestibule, Labyrinth; Vestibulocochlear Nerve | 1972 |
Axonal transport of proteins in retinal ganglion cells. Amino acid incorporation into rapidly transported proteins and distribution of radioactivity to the lateral geniculate body and the superior colliculus.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axonal Transport; Cysteine; Female; Geniculate Bodies; Glycine; Histidine; Leucine; Lysine; Male; Methionine; Nerve Tissue Proteins; Optic Nerve; Phenylalanine; Proline; Rabbits; Retina; Superior Colliculi; Tritium; Tryptophan | 1972 |
Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors.
Topics: Animals; Axonal Transport; Ganglia; Leucine; Mice; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Optic Nerve; Proline; Retina; Retinal Degeneration; Sensory Receptor Cells | 1972 |
Methanolysis of the pyrrolidone ring of amino-terminal pyroglutamic acid in model peptides.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Benzyl Compounds; Butanols; Chromatography, Gas; Crystallization; Esters; Hydrolysis; Isoleucine; Leucine; Lysine; Methanol; Peptides; Proline; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Serine; Staining and Labeling | 1972 |
A retinohypothalamic projection in the rat.
Topics: Animals; Autoradiography; Axonal Transport; Dendrites; Female; Ganglia; Hypothalamus; Leucine; Male; Microscopy, Electron; Nerve Degeneration; Neural Pathways; Optic Chiasm; Optic Nerve; Proline; Rats; Retina | 1972 |
Amino terminal sequences of mammalian type C RNA tumor virus group-specific antigens.
Topics: Amino Acid Sequence; Animals; Antigens, Viral; Arginine; Autoanalysis; Cats; Chromatography, Gas; Chromatography, Gel; Chromatography, Thin Layer; Cross Reactions; Epitopes; Humans; Isoelectric Focusing; Leucine; Mice; Oncogenic Viruses; Proline; Retroviridae; RNA Viruses; Species Specificity; Viral Proteins | 1972 |
Haemoglobin Southampton, 106 (G8) Leu leads to pro: an unstable variant producing severe haemolysis.
Topics: Amino Acid Sequence; Anemia, Hemolytic; Child, Preschool; Female; Hemoglobins, Abnormal; Hemolysis; Heterozygote; Humans; Leucine; Mutation; Proline | 1972 |
Transport of radioactivity from eye to visual cortex in the mouse.
Topics: Action Potentials; Animals; Axonal Transport; Fucose; Geniculate Bodies; Glucosamine; Leucine; Mice; Nerve Tissue Proteins; Optic Nerve; Proline; Protein Precursors; Synaptic Transmission; Tritium; Visual Cortex | 1973 |
Acetylcholine: fast axoplasmic transport in insect chemoreceptor fibers.
Topics: Acetylcholine; Animals; Autoradiography; Axonal Transport; Axons; Brain; Chemoreceptor Cells; Colchicine; Cytochalasin B; Insecta; Leucine; Proline; Tritium; Vinblastine | 1973 |
Autoradiographic evidence for a direct retino-hypothalamic projection in the avian brain.
Topics: Animals; Autoradiography; Axonal Transport; Birds; Columbidae; Hypothalamus; Leucine; Proline; Retina; Synaptic Transmission; Tritium | 1973 |
Observations on the transport of radioactively labeled proteins in the visual system of the chick.
Topics: Animals; Autoradiography; Axonal Transport; Chickens; Leucine; Nerve Tissue Proteins; Neural Pathways; Optic Nerve; Proline; Retina; Superior Colliculi; Tritium; Visual Pathways | 1973 |
Retinohypothalamic projection in mammals: a comparative study.
Topics: Anatomy, Comparative; Animals; Autoradiography; Axonal Transport; Haplorhini; Hedgehogs; Hypothalamus; Leucine; Macaca; Neural Pathways; Opossums; Proline; Retina; Shrews; Species Specificity; Tritium | 1973 |
Regulation of subunit synthesis of Escherichia coli RNA polymerase.
Topics: Carbon Radioisotopes; Cell-Free System; Coliphages; DNA-Directed RNA Polymerases; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Epitopes; Escherichia coli; Genetics, Microbial; Immunoassay; Leucine; Precipitin Tests; Proline; Templates, Genetic; Tritium | 1973 |
Studies on the enzymes involved in the biosynthesis of cyclo-tris (N-2,3-dihydroxybenzoyl-L-seryl) in Escherichia coli: kinetic properties of the L-serine-activating enzyme.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Anti-Bacterial Agents; Drug Stability; Enzyme Induction; Escherichia coli; Ethylmaleimide; Glycine; Gramicidin; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Phosphates; Phosphorus Radioisotopes; Proline; Serine; Threonine; Time Factors; Tritium; Tyrosine | 1973 |
Axonal transport in growing and mature retinal ganglion cells.
Topics: Animals; Autoradiography; Axonal Transport; Chick Embryo; Fucose; Ganglia; Leucine; Optic Nerve; Proline; Rabbits; Rats; Retina; Superior Colliculi; Tritium; Visual Pathways | 1973 |
Differential uptake of (3H)proline and (3H)leucine by neurons: its importance for the autoradiographic tracing on pathways.
Topics: Animals; Autoradiography; Axonal Transport; Cats; Cerebellum; Leucine; Neural Pathways; Neurons; Proline; Reticular Formation; Silver; Staining and Labeling; Tritium | 1973 |
The use of affinity chromatography in determining the sites of protein-protein interaction relative to the binding sites of substrates in gramicidin S synthetase.
Topics: Amino Acid Isomerases; Binding Sites; Chromatography, Affinity; Gramicidin; Leucine; Ligands; Multienzyme Complexes; Ornithine; Peptide Synthases; Phenylalanine; Polysaccharides; Proline; Valine | 1973 |
Biochemical studies on gramicidin S non-producing mutants of Bacillus brevis ATCC 9999.
Topics: Adenosine Triphosphate; Amino Acid Isomerases; Bacillus; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, Paper; Colorimetry; Gramicidin; Leucine; Multienzyme Complexes; Mutation; Nitrosoguanidines; Ornithine; Peptide Synthases; Proline; Radiation Effects; Ultraviolet Rays; Valine | 1974 |
Dynamics of axoplasmic transport in the optic system of the rat.
Topics: Alanine; Animals; Asparagine; Axonal Transport; Circadian Rhythm; Estrus; Female; Leucine; Male; Neurons; Pregnancy; Proline; Rats; Retina; Sex Factors; Solubility; Time Factors; Tritium; Visual Pathways | 1974 |
An automated system for counting silver grains in autoradiographs.
Topics: Animals; Autoradiography; Axonal Transport; Biological Transport, Active; Brain Mapping; Cerebral Cortex; Computers; Leucine; Microscopy; Neural Pathways; Proline; Rats; Silver; Television; Thalamic Nuclei; Tritium | 1974 |
Anatomical analysis of pupillary reflex pathways in the rhesus monkey.
Topics: Animals; Autoradiography; Axonal Transport; Brain Mapping; Leucine; Light; Macaca mulatta; Mesencephalon; Neural Pathways; Oculomotor Nerve; Olivary Nucleus; Proline; Reflex, Pupillary; Superior Colliculi; Thalamic Nuclei; Tritium; Visual Pathways | 1974 |
Axonal transport and turnover of proline- and leucine-labeled protein in the goldfish visual system.
Topics: Animals; Axonal Transport; Axons; Biological Transport; Blood Proteins; Brain; Carbon Radioisotopes; Eye Proteins; Goldfish; Half-Life; Kidney; Leucine; Microscopy, Electron; Nerve Tissue Proteins; Optic Nerve; Organ Specificity; Proline; Superior Colliculi; Time Factors; Tritium | 1974 |
Allylglycine, and inhibitor of the uptake of L-leucine and L-proline in rat brain slices.
Topics: Allyl Compounds; Amino Acids; Animals; Benzenesulfonates; Brain; Carbon Radioisotopes; Catecholamines; Central Nervous System Stimulants; Chromatography, Ion Exchange; Chromatography, Thin Layer; Depression, Chemical; Dinitrophenols; Glutamates; Glycine; In Vitro Techniques; Iodoacetates; Kinetics; Leucine; Mercury; Methionine; Organometallic Compounds; Ouabain; Phenylalanine; Proline; Rats; Time Factors; Tritium; Valine | 1974 |
Heterogeneity of membrane vesicles from Escherichia coli and their subfractionation with antibody to ATPase.
Topics: Adenosine Triphosphatases; Antibodies; Antigen-Antibody Reactions; Bacterial Proteins; Cell Fractionation; Cell Membrane; Escherichia coli; Leucine; NADH, NADPH Oxidoreductases; Proline; Tritium | 1974 |
Distinct components of neutral amino acid transport in chick small intestine.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Chickens; Glycine; Intestinal Absorption; Intestine, Small; Leucine; Male; Proline; Tryptophan | 1974 |
Nature of the gastric secretagogue in Zollinger-Ellison tumours.
Topics: Alanine; Aspartic Acid; Gastrins; Glutamates; Glycine; Humans; In Vitro Techniques; Leucine; Methionine; Proline; Spectrum Analysis; Tryptophan; Tyrosine; Zollinger-Ellison Syndrome | 1967 |
The position of various cleavages of rabbit immunoglobulin G.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Bromine; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Cyanides; Cysteine; gamma-Globulins; Glutamates; Leucine; Lysine; Pepsin A; Proline; Rabbits; Serine; Sulfhydryl Compounds; Threonine; Trypsin | 1968 |
Plasma-aminoacid levels in Huntington's chorea.
Topics: Adult; Alanine; Amino Acids; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle Aged; Proline; Schizophrenia; Tyrosine; Valine | 1969 |
Regulation of the -methylgalactoside transport system and the galatose-binding protein by the cell cycle of Escherichia coli.
Topics: Alanine; Alkaline Phosphatase; Autoradiography; Bacterial Proteins; Carbon Isotopes; Cell Division; Culture Media; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Galactose; Galactosidases; Immunodiffusion; Lactose; Leucine; Mutation; Proline; Protein Binding; Temperature; Transduction, Genetic | 1973 |
Hypothalamic releasing factors and Parkinson disease.
Topics: Antiparkinson Agents; Depression, Chemical; Dihydroxyphenylalanine; Drug Therapy, Combination; Glycine; Humans; Leucine; Melanocyte-Stimulating Hormones; Oligopeptides; Parkinson Disease; Pituitary Hormone-Releasing Hormones; Proline; Thyrotropin-Releasing Hormone | 1974 |
Studies on the inhibition of oxotremorine induced tremor by a melanocyte-stimulating hormone release-inhibiting factor, thyrotropin releasing hormone and related peptides.
Topics: Animals; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Glutamates; Glycine; Histidine; Leucine; Male; Melanocyte-Stimulating Hormones; Mice; Oligopeptides; Oxotremorine; Pituitary Hormone-Releasing Hormones; Proline; Structure-Activity Relationship; Temperature; Thyrotropin-Releasing Hormone; Tremor | 1974 |
D-amino acids in the cell pool of bacteria.
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Bacillus subtilis; Bacteria; Chromatography, Thin Layer; Clostridium; Culture Media; Escherichia coli; Glutamates; Histidine; Hydrogen-Ion Concentration; Lactobacillus; Leucine; Proline; Serine; Spectrophotometry; Staphylococcus; Stereoisomerism; Temperature; Tyrosine | 1974 |
[Study of in vitro differentiation of mandibular molar tooth germs in mouse embryos].
Topics: Alkaline Phosphatase; Animals; Autoradiography; Cell Differentiation; Culture Techniques; Histocytochemistry; Leucine; Mice; Mitosis; Molar; Proline; Thymidine; Time Factors; Tooth Germ; Tritium | 1970 |
[Study of the action of dexamethasone phosphate on germs of mandibular molar tooth germs in mouse embryos cultivated in vitro].
Topics: Alkaline Phosphatase; Animals; Autoradiography; Cell Differentiation; Culture Techniques; Dexamethasone; Histocytochemistry; Leucine; Mice; Mitosis; Molar; Proline; Thymidine; Time Factors; Tooth Germ; Tritium | 1970 |
Preparation and properties of smooth muscle myosin from horse esophagus.
Topics: Adenosine Triphosphatases; Amino Acids; Animals; Asparagine; Aspartic Acid; Calcium; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Edetic Acid; Enzyme Activation; Esophagus; Ethylmaleimide; Glycine; Horses; Leucine; Lysine; Magnesium; Muscle Proteins; Muscle, Smooth; Muscles; Organ Specificity; Osmolar Concentration; Phosphorus; Potassium Chloride; Proline; Rabbits; Sulfhydryl Compounds; Temperature; Ultracentrifugation | 1970 |
[Plasma amino acid levels in children of patients with Huntington's chorea].
Topics: Adolescent; Adult; Alanine; Amino Acids; Child; Child, Preschool; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle Aged; Proline; Schizophrenia; Tyrosine | 1972 |
The effects of the nicotinamide sensitive teratogen 3-acetylpyridine on chick limb mesodermal cells in culture: biochemical parameters.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; DNA; Glycosaminoglycans; Ketones; Leucine; Limb Deformities, Congenital; Mesoderm; Muscles; Niacinamide; Phenotype; Proline; Pyridines; RNA; Thymidine; Tritium; Uridine | 1972 |
Energization of active transport by Escherichia coli.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Aerobiosis; Alanine; Anaerobiosis; Arsenic; Biological Transport, Active; Cell Membrane; Dinitrophenols; Energy Transfer; Escherichia coli; Glutamates; Lactates; Leucine; Oxidative Phosphorylation; Phosphoenolpyruvate; Proline | 1972 |
Effects of cell density on the expression of differentiation by chick embryo chondrocytes.
Topics: Animals; Cartilage; Cell Count; Cell Differentiation; Cells, Cultured; Chick Embryo; Collagen; Culture Media; Glycosaminoglycans; Histocytochemistry; Leucine; Methods; Proline; Protein Biosynthesis; Sulfur Radioisotopes; Time Factors; Tritium | 1974 |
Association of axonally transported proteins with goldfish brain myelin fractions.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Axons; Biological Transport; Brain; Centrifugation, Density Gradient; Centrifugation, Zonal; Cyprinidae; Electrophoresis, Polyacrylamide Gel; Glycolipids; Goldfish; Kinetics; Leucine; Microscopy, Electron; Molecular Weight; Myelin Sheath; Nerve Tissue Proteins; Optic Nerve; Proline; RNA; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1974 |
Intestinal adaptation in diabetes: amino acid absorption.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Chromatography, Paper; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glycine; Intestinal Absorption; Intestinal Mucosa; Leucine; Lysine; Male; Organ Size; Proline; Rats; Serous Membrane; Streptozocin; Time Factors | 1974 |
Depression by hyaluronic acid of glycosaminoglycan synthesis by cultured chick embryo chondrocytes.
Topics: Animals; Bone Matrix; Carbon Radioisotopes; Cartilage; Cattle; Cell Differentiation; Cells, Cultured; Chick Embryo; Chondroitin; Collagen; Culture Media; Depression, Chemical; Glucosamine; Glycosaminoglycans; Hyaluronic Acid; Leucine; Monosaccharides; Oligosaccharides; Proline; Proteoglycans; Sulfates; Sulfur Radioisotopes; Thymidine; Time Factors | 1974 |
The effects of L-azetidine-2-carboxylic acid (analogue of proline) on dental cytodifferentiations in vitro.
Topics: Ameloblasts; Animals; Autoradiography; Azetidines; Azetines; Carbon Radioisotopes; Carboxylic Acids; Cell Differentiation; Cell Division; Collagen; Glycosaminoglycans; Leucine; Lysine; Mice; Microscopy, Electron; Odontoblasts; Proline; Tooth Germ; Tritium | 1974 |
5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli.
Topics: Adenine; Aspartic Acid; Escherichia coli; Glutamates; Glutamine; Glycine; Hydrogen-Ion Concentration; Leucine; Ligases; Peptides; Phosphoric Monoester Hydrolases; Proline; Spectrophotometry; Tyrosine; Venoms | 1968 |
Primary structure of insoluble tendon collagen. II. N- and C-terminal positional analysis of collagenolytic breakdown products of trypsin-pretreated collagen.
Topics: Achilles Tendon; Alanine; Amino Acids; Animals; Arginine; Cattle; Collagen; Glycine; Hydroxyproline; Isoleucine; Leucine; Methionine; Methods; Microbial Collagenase; Phenylalanine; Proline; Threonine; Trypsin; Tyrosine | 1968 |
Amino acid uptake in isolated chick embryo heart cells.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Chick Embryo; Glycine; Heart; Histidine; In Vitro Techniques; Insulin; Leucine; Methionine; Microbial Collagenase; Myocardium; Oxygen Consumption; Proline; Protein Biosynthesis; Serine; Threonine | 1969 |
The effect of acute exercise on amino acid incorporation into mitochondria of rabbit tissues.
Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Aging; Amino Acids; Animals; Brain; Buffers; Carbon Isotopes; Centrifugation, Density Gradient; Hypoxia; Leucine; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen; Physical Exertion; Proline; Protein Biosynthesis; Quaternary Ammonium Compounds; Rabbits; Swimming; Testosterone | 1969 |
Synthesis of corticotrophin-like polypeptides and protein by bovine hypothalamus, median eminence and pituitary tissue slices.
Topics: Adrenocorticotropic Hormone; Animals; Carboxypeptidases; Cattle; Chromatography; Chromatography, Gel; Hypothalamo-Hypophyseal System; Hypothalamus; In Vitro Techniques; Leucine; Molecular Weight; Peptide Biosynthesis; Phenylalanine; Pituitary Gland; Proline; Protein Biosynthesis | 1969 |
Metabolic and virologic studies in primate liver organ cultures.
Topics: Animals; Autoradiography; Centrifugation, Density Gradient; Culture Techniques; DNA; Enterovirus; Haplorhini; Herpesviridae; Interferons; Leucine; Liver; Organ Culture Techniques; Orthomyxoviridae; Proline; Protein Biosynthesis; RNA; Thymidine; Tritium; Tyrosine; Uridine; Virus Replication | 1970 |
Nonribosomal polypeptide synthesis: the biosynthesis of a cyclic peptide antibiotic, gramicidin S.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acid Sequence; Amino Acids; Bacillus; Chemical Precipitation; Chromatography, Gel; Diphosphates; Electrophoresis; Enzymes; Hydroxamic Acids; Leucine; Ligases; Models, Biological; Models, Structural; Ornithine; Peptide Biosynthesis; Peptides; Phenylalanine; Phosphorus Isotopes; Proline; Protein Denaturation; Ribosomes; Sulfhydryl Compounds; Trichloroacetic Acid; Tritium; Tyrothricin; Valine | 1969 |
Biosynthesis of cyclic oligopeptide.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Bacillus; Carbon Isotopes; Chromatography, Ion Exchange; Depression, Chemical; Diphosphates; Enzymes; Filtration; Heterocyclic Compounds; Isomerases; Leucine; Ligases; Magnesium; Metabolism; Mutation; Peptide Biosynthesis; Phenylalanine; Piperazines; Proline; Protein Biosynthesis; Pyrophosphatases; Stimulation, Chemical; Tyrothricin | 1969 |
Relationship of a membrane-bound D-(-)-lactic dehydrogenase to amino acid transport in isolated bacterial membrane preparations.
Topics: Acetates; Amino Acids; Biological Transport, Active; Butyrates; Carbon Isotopes; Citrates; Escherichia coli; Formates; Fumarates; Glyceric Acids; Hexosephosphates; Histidine; Hydroxybutyrates; Isoleucine; Ketoglutaric Acids; L-Lactate Dehydrogenase; Lactates; Leucine; Malates; Membranes; NAD; Oxaloacetates; Phenylalanine; Proline; Pyruvates; Stereoisomerism; Succinates; Thyroxine | 1970 |
Cyclic AMP stimulation of amino acid uptake in bone and kidney.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adenylyl Cyclases; Amino Acids; Aminoisobutyric Acids; Animals; Bone and Bones; Butyrates; Carbon Isotopes; Cyclic AMP; Enzyme Activation; Extracellular Space; Female; Fetus; Glycine; Guanine Nucleotides; In Vitro Techniques; Insulin; Kidney; Leucine; Male; Parathyroid Hormone; Pregnancy; Proline; Rats; Stimulation, Chemical; Time Factors | 1970 |
Quantitative differences in proline tRNA content of rat liver and granulation tissue.
Topics: Alanine; Albumins; Amino Acids; Animals; Carbon Isotopes; Chromatography; Granulation Tissue; Leucine; Liver; Male; Proline; Protein Biosynthesis; Rats; RNA, Transfer; Silicon Dioxide; Solubility; Tritium; Tyrosine | 1970 |
[Biosynthesis of the basement membrane. Utilization of proline and glucose for the formation of components of the glomerular basement membrane in vitro].
Topics: Animals; Basement Membrane; Carbon Isotopes; Cattle; Chromatography, Gel; Chromatography, Thin Layer; Cycloheximide; Depression, Chemical; Diuretics; Glucose; Glycine; Glycoproteins; Hydroxyproline; In Vitro Techniques; Kidney Glomerulus; Leucine; Microbial Collagenase; Peptide Hydrolases; Phlorhizin; Proline; Puromycin; Pyrazines; Rats | 1971 |
[Chromophore substrates. 3. An improved method for the preparation of the colored colagenase substrate 4-phenylazobenzyl-oxycarbonyl-L-propyl-L-leucyl-glycyl-L-propyl-D-arginine].
Topics: Arginine; Chemical Phenomena; Chemistry; Glycine; Leucine; Methods; Microbial Collagenase; Peptides; Proline | 1971 |
Cyclic adenosine monophosphate-stimulated transport of amino acids in kidney cortex.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Biological Transport, Active; Butyrates; Carbon Isotopes; Cyclic AMP; Cycloheximide; Glycine; Insulin; Kidney; Kinetics; Leucine; Lysine; Male; Ouabain; Parathyroid Hormone; Proline; Puromycin; Rats; Sodium; Vasopressins | 1972 |
MSH-release-inhibiting factor: inactivation by proteolytic enzymes.
Topics: Aminopeptidases; Animals; Brain; Carboxypeptidases; Cattle; Cell Fractionation; Chymotrypsin; Endopeptidases; Glycine; Leucine; Leucyl Aminopeptidase; Male; Melanocyte-Stimulating Hormones; Methods; Microbial Collagenase; Peptide Hydrolases; Peptides; Proline; Rats; Swine; Thermolysin; Tissue Extracts | 1972 |
Some mutants of Bacillus brevis deficient in gramicidin S formation.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Bacillus; Carbon Isotopes; Carcinogens; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Diphosphates; Isomerases; Leucine; Mutation; Nitro Compounds; Nitrosoguanidines; Ornithine; Phenylalanine; Phosphorus Isotopes; Piperazines; Proline; Tyrothricin; Valine | 1972 |
Influence of gonadotrophins and cyclic AMP on carbohydrate and protein metabolism in the immature rat ovary.
Topics: Age Factors; Aminoisobutyric Acids; Animals; Carbon Isotopes; Cyclic AMP; Female; Follicle Stimulating Hormone; Glucose; In Vitro Techniques; Lactates; Leucine; Luteinizing Hormone; Ovary; Proline; Rats; Tritium | 1973 |
Specificity of aeromonas aminopeptidase toward oligopeptides and polypeptides.
Topics: Adrenocorticotropic Hormone; Aeromonas; Amides; Amino Acid Sequence; Amino Acids; Aminopeptidases; Autoanalysis; Electrophoresis, Paper; Glucagon; Hydrolysis; Insulin; Leucine; Oligopeptides; Peptides; Proline; Structure-Activity Relationship | 1973 |
Hemoglobin Abraham Lincoln, beta32 (B14) leucine leads to proline. An unstable variant producing severe hemolytic disease.
Topics: Adult; Amino Acids; Anemia, Hemolytic; Carbon Isotopes; Carbon Monoxide; Chemical Precipitation; Chromatography, Ion Exchange; Chromium Isotopes; Electrophoresis; Erythrocytes; Female; Half-Life; Heme; Hemoglobins, Abnormal; Hot Temperature; Humans; Hydroxymercuribenzoates; Inclusion Bodies; Leucine; Methemoglobin; Proline; Reticulocytes; Sulfites | 1973 |
Inactivation of melanocyte-stimulating hormone release-inhibiting factor by a manganese-stimulated bovine brain aminopeptidase.
Topics: Aminopeptidases; Angiotensin II; Animals; Bradykinin; Brain; Cattle; Glycine; Kidney; Leucine; Leucyl Aminopeptidase; Luteinizing Hormone; Manganese; Melanocyte-Stimulating Hormones; Oligopeptides; Oxytocin; Pituitary Hormone-Releasing Hormones; Proline; Structure-Activity Relationship; Swine; Thyrotropin-Releasing Hormone; Vasotocin | 1973 |
Protein and glycoprotein subunit composition of plasma membrane from chick embryo fibroblasts.
Topics: Animals; Carbon Radioisotopes; Cell Membrane; Chick Embryo; Electrophoresis, Disc; Fibroblasts; Glucosamine; Glycoproteins; Hexosamines; Iodine Radioisotopes; Leucine; Macromolecular Substances; Microbial Collagenase; Molecular Weight; Peptides; Periodic Acid; Proline; Protein Biosynthesis; Proteins; Sodium Dodecyl Sulfate; Tritium | 1974 |
Protein synthesis and secretion in a myogenic cell line.
Topics: Animals; Carbon Radioisotopes; Cell Differentiation; Cell Line; Clone Cells; Collagen; Creatine Kinase; Electrophoresis, Polyacrylamide Gel; Hydroxyproline; In Vitro Techniques; Leucine; Muscle Proteins; Muscles; Myofibrils; Myosins; Phosphotransferases; Proline; Rats; Time Factors; Tritium | 1973 |
Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.
Topics: Amino Acids; Animals; Arginine; Asparagine; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Culture Media; Cycloheximide; Drug Synergism; Glutamine; Glycine; Immune Sera; Leucine; Liver Neoplasms; Neoplasm Proteins; Ornithine; Proline; Pyridoxal; Rats; Serine; Stimulation, Chemical; Time Factors | 1974 |
Radical yield in X-irradiated biological molecules. II. Naturally-occurring amino-acids.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamates; Histamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Iontophoretic and autoradiographic studies on the role of proline in nervous transmission.
Topics: Alkaloids; Animals; Autoradiography; Cats; Cerebellar Cortex; Dioxoles; Iontophoresis; Isoquinolines; Leucine; Methods; Proline; Purkinje Cells; Strychnine; Synaptic Transmission; Tritium | 1974 |
Inhibitory effect of complex formation with oligodeoxyribonucleotide ethyl phosphotriesters on transfer ribonucleic acid aminoacylation.
Topics: Amino Acyl-tRNA Synthetases; Anticodon; Base Sequence; Binding Sites; Deoxyribonucleotides; Diphosphates; Escherichia coli; Kinetics; Leucine; Lysine; Oligonucleotides; Phenylalanine; Phosphorus Radioisotopes; Proline; Protein Binding; RNA, Bacterial; RNA, Transfer; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Time Factors; Tritium; Tyrosine | 1974 |
Amino acid sequence of an alkaline proteinase inhibitor (Streptomyces subtilisin inhibitor) from Streptomyces albogriseolus S-3253.
Topics: Alanine; Amino Acid Sequence; Chymotrypsin; Cyanogen Bromide; Leucine; Methylation; Microbial Collagenase; Proline; Streptomyces; Subtilisins; Thermolysin; Threonine; Trypsin; Trypsin Inhibitors | 1974 |
[Further studies on amino acid sequence of proteins in tobacco mosaic virus].
Topics: Alanine; Amino Acid Sequence; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Chromatography, Paper; Electrophoresis; Glutamates; Leucine; Peptides; Proline; Threonine; Tobacco Mosaic Virus; Valine; Viral Proteins | 1965 |
[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine in the induction of mutation. I. Effect of 1-nitroso-3-nitro-1-methylguanidine on the template activity of polyncleotides in cell-free protein synthesis].
Topics: Adenine Nucleotides; Amino Acids; Bacterial Proteins; Cell-Free System; Cytosine Nucleotides; Escherichia coli; Guanidines; Guanine Nucleotides; Leucine; Lysine; Molecular Biology; Mutagens; Mutation; Nitroso Compounds; Phenylalanine; Polynucleotides; Proline; Ribosomes; RNA, Bacterial; RNA, Transfer; Serine; Templates, Genetic; Tritium; Uracil Nucleotides | 1967 |
Thermal denaturation equilibria of TMV coat proteins with chemically defined differences in their primary structure.
Topics: Genetics, Microbial; Hot Temperature; Kinetics; Leucine; Mutation; Optical Rotatory Dispersion; Proline; Protein Denaturation; Spectrophotometry; Tobacco Mosaic Virus; Ultracentrifugation; Ultraviolet Rays; Viral Proteins | 1969 |
Kinetic behavior of D-amino acid oxidase in its reaction with basic amino acids.
Topics: Alanine; Amino Acids; Arginine; D-Amino-Acid Oxidase; In Vitro Techniques; Kinetics; Leucine; Phenylalanine; Proline; Valine | 1970 |
Release of alpha imino acid as primary product in D-amino-acid oxidase reaction.
Topics: Alanine; Chemical Phenomena; Chemistry; D-Amino-Acid Oxidase; Hydrogen-Ion Concentration; Imines; Leucine; Oxygen Consumption; Proline | 1970 |
Fluorometric assay of amino acids.
Topics: Amino Acid Oxidoreductases; Amino Acids; Arginine; Benzoates; D-Amino-Acid Oxidase; Fluorometry; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leucine; Methionine; Methods; Phenylacetates; Phenylalanine; Proline; Stereoisomerism; Tryptophan; Tyrosine | 1968 |
Isolation and structure of hypothalamic MSH release-inhibition hormone.
Topics: Amides; Amino Acid Sequence; Amino Acids; Animals; Anura; Biological Assay; Carbon Isotopes; Cattle; Chromatography, Gel; Chromatography, Thin Layer; Depression, Chemical; Electrophoresis; Fluorescence; Glycine; Hypothalamus; Isomerism; Leucine; Mass Spectrometry; Melanocyte-Stimulating Hormones; Neurotransmitter Agents; Peptides; Pituitary Hormone-Releasing Hormones; Proline; Skin; Sulfonic Acids; Thiocyanates; Ultraviolet Rays | 1971 |
Mutant strains of Escherichia coli K12 that use D-amino acids.
Topics: Amino Acids; Arginine; Chromosome Mapping; Coliphages; D-Amino-Acid Oxidase; Escherichia coli; Genetic Linkage; Genotype; Histidine; Isoleucine; Isomerism; Leucine; Lysine; Mutation; Phenylalanine; Proline; Serine; Threonine; Transduction, Genetic; Tryptophan; Tyrosine; Valine | 1971 |
Thin-layer chromatographic determination of the optical purity of labeled amino acids via dipeptide formation.
Topics: Amino Acids; Anhydrides; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; D-Amino-Acid Oxidase; Densitometry; Dipeptides; Leucine; Methods; Proline; Stereoisomerism; Tritium | 1972 |
A distinct component of proline transport in chicken small intestine.
Topics: Animals; Biological Transport; Chickens; Female; Glycine; Intestinal Absorption; Intestine, Small; Leucine; Proline | 1972 |
Protein and peptide hydrolases of the rat hypothalamus and pituitary.
Topics: Aminopeptidases; Animals; Cerebral Cortex; Dipeptides; Endopeptidases; Glycine; Hemoglobins; Hypothalamus; Kinetics; Leucine; Male; Oligopeptides; Organ Specificity; Peptide Hydrolases; Pituitary Gland; Pituitary Gland, Posterior; Pituitary Hormones; Proline; Structure-Activity Relationship | 1974 |
In vitro studies on the uptake and incorporation of natural amino acids in rabbit choroid plexus.
Topics: Absorption; Amino Acids; Animals; Biological Transport; Carbon Radioisotopes; Chloramphenicol; Choroid Plexus; Cycloheximide; Glutamates; Glycine; Histidine; Inulin; Isoleucine; Kinetics; Leucine; Osmotic Pressure; Phenylalanine; Proline; Puromycin; Rabbits; Tritium; Tyrosine | 1974 |
Action of insulin on amino acid uptake by the immature rat uterus in vitro.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Radioisotopes; Cattle; Choline; Ethylmaleimide; Female; Glycine; Insulin; Kinetics; Leucine; Methionine; Proline; Puromycin; Rats; Receptors, Drug; Sodium; Time Factors; Uterus; Valine | 1974 |
An autoradiographic study of the efferent connections of the ventral lateral geniculate nucleus in the albino rat and the cat.
Topics: Animals; Autoradiography; Brain Mapping; Cats; Geniculate Bodies; Hypothalamus; Leucine; Neural Pathways; Neurons; Neurons, Efferent; Proline; Rats; Retina; Species Specificity; Superior Colliculi; Tritium; Visual Cortex; Visual Pathways | 1974 |
An autoradiographic study of the projections of the dorsal lateral geniculate nucleus and the posterior nucleus in the cat.
Topics: Animals; Autoradiography; Cats; Cerebral Cortex; Geniculate Bodies; Hypothalamus; Leucine; Proline; Thalamic Nuclei; Tritium | 1974 |
Metabolism of L-azetidine-2-carboxylic acid in the alga Cyanidium caldarium.
Topics: Azetidines; Azetines; Carbon Radioisotopes; Chlorophyll; Darkness; Eukaryota; Imino Acids; Leucine; Pigments, Biological; Plant Proteins; Proline; Spectrophotometry, Ultraviolet; Subcellular Fractions; Time Factors; Ultracentrifugation; Ultrasonics | 1974 |
Amino acid transport in human placental slices.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Biological Transport, Active; Carbon Radioisotopes; Chromatography, Paper; Extracellular Space; Female; Glutamates; Glycine; Humans; In Vitro Techniques; Kidney; Leucine; Lysine; Placenta; Pregnancy; Proline; Rats; Serine; Time Factors | 1974 |
Involvement of glutamate in memory formation.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Chickens; Conditioning, Classical; Electroencephalography; Glutamates; Glutamine; Injections, Intraperitoneal; Injections, Intravenous; Isoleucine; Leucine; Memory; Memory, Short-Term; Proline | 1974 |
Free amino acid levels in the boll weevil (Coleoptera: Curculionidae): the effect of five different diets.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chromatography, Gas; Coleoptera; Diet; Dietary Proteins; Glutamates; Glycine; Gossypium; Histidine; Isoleucine; Leucine; Male; Mass Spectrometry; Methionine; Phenylalanine; Proline; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Protein synthesis in vitro by the rat brain in course of experimental cyanide encephalopathy.
Topics: Animals; Brain; Brain Diseases; Cyanides; Demyelinating Diseases; Disease Models, Animal; Female; Hypoxia; Leucine; Male; Myelin Sheath; Nerve Tissue Proteins; Poisoning; Proline; Rats | 1974 |
The far-infrared properties of polyamino acids.
Topics: Absorption; Alanine; Amino Acid Sequence; Amino Acids; Caseins; Leucine; Mathematics; Myoglobin; Oligopeptides; Ovalbumin; Peptides; Proline; Solutions; Solvents; Spectrophotometry, Infrared; Temperature | 1974 |
Free amino acids in the haemocytes and plasma of the larva of Calliphora vicina.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Blood Cells; Blood Coagulation; Diptera; Glutamates; Glutamine; Glycine; Hemolymph; Histidine; Isoleucine; Larva; Leucine; Lysine; Methionine; Phenylalanine; Plasma; Proline; Serine; Taurine; Threonine; Tyrosine; Valine | 1974 |
Study of serum amino acids in Egyptian lead workers.
Topics: Adult; Alanine; Amino Acids; Colorimetry; Egypt; Glutamates; Glycine; Histidine; Humans; Lead Poisoning; Leucine; Lysine; Male; Middle Aged; Proline; Serine; Tyrosine; Valine | 1974 |
The structural code for proteins: zonal distribution of amino acid residues and stabilization of helices by hydrophobic triplets.
Topics: Alanine; Amino Acids; Aspartic Acid; Computers; Isoleucine; Leucine; Mathematics; Models, Molecular; Proline; Protein Conformation; Statistics as Topic; Tyrosine; Valine | 1974 |
Experiments on the origin of molecular chirality by parity non-conservation during beta-decay.
Topics: Leucine; Norleucine; Optical Rotation; Proline; Radiation Effects; Stereoisomerism; Strontium Radioisotopes; Tyrosine; Valine; Yttrium Radioisotopes | 1974 |
Prebiotic synthesis of hydrophobic and protein amino acids.
Topics: Alanine; Amino Acids; Aminobutyrates; Aminoisobutyric Acids; Ammonia; Aspartic Acid; Autoanalysis; Chromatography, Gas; Glutamates; Glycine; Isoleucine; Leucine; Mass Spectrometry; Methane; Nitrogen; Proline; Serine; Threonine; Valine; Water | 1972 |
Specific glycine--accumulating synaptosomes in the spinal cord of rats.
Topics: Aminobutyrates; Animals; Arginine; Aspartic Acid; Brain Stem; Carbon Isotopes; Cell Fractionation; Centrifugation, Density Gradient; Cerebral Cortex; Glutamates; Glycine; Leucine; Lysine; Male; Nerve Endings; Proline; Rats; Spinal Cord; Subcellular Fractions; Synaptic Vesicles; Synaptosomes; Threonine; Tritium; Tyrosine | 1972 |
Accumulation and transport of amino acids by the frog choroid plexus.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Anura; Biological Transport, Active; Carbon Isotopes; Choroid Plexus; Glutamates; Glycine; Inulin; Leucine; Mannitol; Potassium; Proline; Rana catesbeiana; Sodium | 1972 |
Evidence that Pro-Leu-Gly-NH 2 , tocinoic acid, and des-Cys-tocinoic acid do not affect secretion of melanocyte stimulating hormone.
Topics: Amino Acid Sequence; Animals; Anura; Cells, Cultured; Chromatography, Thin Layer; Cystine; Disulfides; Glycine; In Vitro Techniques; Leucine; Male; Melanocyte-Stimulating Hormones; Oxytocin; Peptides, Cyclic; Pituitary Gland; Proline; Rana pipiens; Rats; Skin | 1973 |
Autoradiographic demonstration of optic nerve fibers in the stratum zonale of the frog's tectum.
Topics: Animals; Anura; Autoradiography; Leucine; Optic Nerve; Proline; Rana pipiens; Superior Colliculi; Thalamus; Tritium | 1973 |
Messenger activity of nuclear RNA of frog embryos.
Topics: Animals; Cell Nucleus; Female; Leucine; Microinjections; Ovum; Proline; Protein Biosynthesis; Rana pipiens; RNA, Messenger; Templates, Genetic; Time Factors; Tritium; Xenopus | 1974 |
Recombination in Escherichia coli. V. Genetic analysis of recombinants from crosses with recipients deficient in ATP-dependent exonuclease activity.
Topics: Adenosine Triphosphate; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Crosses, Genetic; Deoxyribonucleases; Drug Resistance, Microbial; Escherichia coli; Genetic Linkage; Leucine; Mathematics; Probability; Proline; Recombination, Genetic; Streptomycin; Threonine; Thymine; Time Factors; Transduction, Genetic | 1972 |
Syntheses and LH- and FSH-RH activities of LH-RH analogs substituted at position 8.
Topics: Animals; Biological Assay; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Female; Follicle Stimulating Hormone; Glycine; Leucine; Luteinizing Hormone; Methods; Ovary; Pituitary Hormone-Releasing Hormones; Proline; Radioimmunoassay; Rats; Structure-Activity Relationship; Swine | 1972 |
Structure of a hypothalamic peptide possessing gonadotropin-releasing activity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Carbon Isotopes; Glutamates; Glycine; Gonadotropins; Histidine; Hypothalamus; Leucine; Mass Spectrometry; Peptide Chain Termination, Translational; Pituitary Hormone-Releasing Hormones; Proline; Serine; Swine; Tryptophan; Tyrosine | 1972 |
Synthesis and biological activities of analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 1 or 2.
Topics: Animals; Castration; Female; Glutamates; Glycine; Leucine; Luteinizing Hormone; Ovary; Peptide Chain Elongation, Translational; Phenylalanine; Pituitary Hormone-Releasing Hormones; Proline; Rats; Serine; Structure-Activity Relationship | 1973 |
General activity in intact and hypophysectomized rats after administration of melanocyte-stimulating hormone (MSH), melatonin, and PRO-LEU-GLY-NH 2 .
Topics: Animals; Glycine; Hypophysectomy; Leucine; Locomotion; Male; Melanocyte-Stimulating Hormones; Melatonin; Motor Activity; Oligopeptides; Peptides; Pituitary Gland; Pituitary Hormone-Releasing Hormones; Proline; Rats | 1973 |
Abnormal excision and transfer of chromosomal segments by a strain of Escherichia coli K-12.
Topics: Acridines; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Crosses, Genetic; DNA Replication; Escherichia coli; Galactose; Genes; Genetic Linkage; Leucine; Mutation; Proline; Recombination, Genetic; Temperature; Threonine; Xylose | 1972 |
Effects of proline analogues on the formation of alkaline phosphatase in Escherichia coli.
Topics: Alkaline Phosphatase; Amino Acids; Bacterial Proteins; Carbon Radioisotopes; Cell Membrane; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Leucine; Mutation; Proline; Spheroplasts; Tritium | 1972 |
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, Thin Layer; Dansyl Compounds; Diabetes Mellitus; Fasting; Female; Freeze Drying; Glutamates; Glycine; Islets of Langerhans; Leucine; Lysine; Mice; Obesity; Ornithine; Phenylalanine; Proline; Taurine; Tritium; Valine | 1974 |
Activity of polypeptide chain initiation factors during a nutritional shift-up in Escherichia coli.
Topics: Acetates; Amino Acids; Carbon Radioisotopes; Cell Division; Chromatography, Gel; Coliphages; Escherichia coli; Glucose; Leucine; Methionine; Mutation; Nucleosides; Peptide Initiation Factors; Proline; Protein Biosynthesis; RNA, Messenger; RNA, Transfer; RNA, Viral; Spectrophotometry; Time Factors; Tritium; Viral Proteins | 1974 |
[Effect of inhibitors of protein and nucleic acid synthesis on the form of the nucleoid of Escherichia coli].
Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbon Radioisotopes; Cell Nucleus; Centrifugation, Density Gradient; DNA, Bacterial; Escherichia coli; Leucine; Microscopy, Electron; Proline; RNA, Bacterial; Thymidine; Transcription, Genetic; Tritium; Uridine; Valine | 1974 |
Evolution of a new gene substituting for the leuD gene of Salmonella typhimurium: characterization of supQ mutations.
Topics: Chromosome Mapping; Crosses, Genetic; Dicarboxylic Acids; Genes; Isomerases; Leucine; Models, Biological; Mutagens; Mutation; Nitrites; Proline; Salmonella; Salmonella typhimurium; Suppression, Genetic; Temperature; Transduction, Genetic; Valerates | 1974 |
Studies on T4-tRNA biosynthesis: accumulation of precursor tRNA molecules in a temperature sensitive mutant of Escherichia coli.
Topics: Base Sequence; Coliphages; Densitometry; Drug Stability; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glycine; Leucine; Mutation; Phosphorus Radioisotopes; Proline; Ribonucleases; Ribonucleotides; RNA, Transfer; RNA, Viral; Serine; Temperature; Time Factors; Transcription, Genetic; Virus Replication | 1974 |
Basis of transport discrimination of arginine from other basic amino acids in Salmonella typhimurium.
Topics: Alanine; Amino Acids; Arginine; Autoanalysis; Biological Transport; Carbon Radioisotopes; Chromatography, Ion Exchange; Deuterium; Glucose; Histidine; Homoserine; Hydroxyproline; Kinetics; Leucine; Lysine; Magnetic Resonance Spectroscopy; Mathematics; Ornithine; Proline; Salmonella typhimurium; Structure-Activity Relationship; Tritium; Tryptophan | 1974 |
Evolution of a new gene substituting for the leuD gene of Salmonella typhimurium: origin and nature of supQ and newD mutations.
Topics: Adenine; Chromosome Mapping; Crosses, Genetic; Genes; Genetic Linkage; Leucine; Lysogeny; Models, Biological; Mutagens; Mutation; Nitrosoguanidines; Proline; Salmonella Phages; Salmonella typhimurium; Transduction, Genetic | 1974 |
An autoradiographic and electron microscopic study of retino-hypothalamic connections.
Topics: Animals; Autoradiography; Axons; Cats; Dendrites; Glycogen; Guinea Pigs; Haplorhini; Hypothalamus; Leucine; Macaca; Microscopy; Microscopy, Electron; Mitochondria; Neurosecretion; Proline; Rabbits; Rats; Retina; Synapses; Synaptic Vesicles; Tritium | 1972 |
[Amino acids in parenteral feeding].
Topics: Alanine; Amino Acids; Arginine; Histidine; Homeostasis; Humans; Isoleucine; Leucine; Lysine; Male; Methionine; Nutrition Disorders; Parenteral Nutrition; Phenylalanine; Proline; Protein Conformation; Protein-Energy Malnutrition; Proteins; Threonine; Tryptophan; Valine | 1972 |
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine; Haplorhini; Humans; Injections, Intraperitoneal; Leucine; Mice; Oligopeptides; Pargyline; Proline; Reserpine; Secologanin Tryptamine Alkaloids | 1973 |
A strong competitive peptide-inhibitor for leucine aminopeptidase.
Topics: Anilides; Calcitonin; Chemical Phenomena; Chemistry; Humans; Hydrolysis; Leucine; Leucyl Aminopeptidase; Ligands; Magnetic Resonance Spectroscopy; Nitro Compounds; Peptides; Phenylalanine; Proline; Protons; Spectrum Analysis; Threonine | 1972 |
Preliminary clinical studies with L-prolyl-L-leucyl-glycine amide in Parkinson's disease.
Topics: Administration, Oral; Aged; Amides; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Glycine; Humans; Injections, Intravenous; Leucine; Male; Middle Aged; Movement Disorders; Parkinson Disease; Peptides; Proline | 1972 |
The chemical composition of wool. XI. Separation and analysis of exocuticle and endocuticle.
Topics: Amino Acids; Animals; Aspartic Acid; Coloring Agents; Cysteine; Cystine; Formates; Histidine; Leucine; Lysine; Methionine; Microscopy, Electron; Phenylalanine; Proline; Pronase; Sheep; Structure-Activity Relationship; Threonine; Tyrosine; Wool | 1972 |
[Amino acid metabolism pathology in the convulsive syndrome in young children].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Child, Preschool; Cystine; Female; Glutamates; Glutamine; Glycine; Histidine; Humans; Infant; Infant, Newborn; Leucine; Lysine; Male; Methionine; Proline; Seizures; Serine; Tryptophan; Tyrosine; Valine | 1972 |
The adaptation of diastereomeric S-prolyl dipeptide derivatives to the quantitative estimation of R- and S-leucine enantiomers.
Topics: Amino Acid Sequence; Chromatography, Gas; Dipeptides; Esters; Leucine; Methods; Methylation; Proline; Stereoisomerism | 1972 |
Interaction of 4-nitroquinoline 1-oxide and related carcinogens with histone and aliphatic amino acids.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Carcinogens; Cattle; Chemical Phenomena; Chemistry; Glutamates; Glycine; Histones; Isoleucine; Leucine; Lysine; Methionine; Proline; Protein Denaturation; Quinolines; Serine; Spectrophotometry; Threonine; Thymus Gland; Valine | 1972 |
Raman spectroscopy.
Topics: Alanine; Amides; Evaluation Studies as Topic; Glutamates; Glycine; Lasers; Leucine; Mathematics; Methods; Muramidase; Peptides; Proline; Protein Conformation; Spectrophotometry, Ultraviolet; Spectrum Analysis | 1972 |
A new case of hemoglobin Genova 2 2 28(B10) Leu leads to Pro. Further studies on the mechanism of instability and defective synthesis.
Topics: Amino Acids; Blood Protein Electrophoresis; Carbon Isotopes; Child; Chromatography, Ion Exchange; Drug Stability; Electrophoresis, Starch Gel; Genetics, Medical; Heme; Hemoglobins; Hemoglobins, Abnormal; Hot Temperature; Humans; Italy; Leucine; Macromolecular Substances; Male; Mutation; Oxygen; Partial Pressure; Peptides; Proline; Reticulocytes | 1973 |
Specific transfer process for intestinal absorption of peptides.
Topics: Alanine; Animals; Dipeptides; Glycine; Intestinal Absorption; Leucine; Methionine; Proline; Rats | 1973 |
Effect of pentobarbital on amino acid and urea flux in the isolated dog brain.
Topics: Amino Acids; Anesthesia, General; Animals; Asparagine; Aspartic Acid; Brain; Cerebrovascular Circulation; Dipeptides; Dogs; Glutamates; Glutamine; Glycine; Halothane; Isoleucine; Leucine; Methoxyflurane; Nitrogen; Pentobarbital; Proline; Serine; Taurine; Urea; Valine | 1973 |
Distribution, half-life, and excretion of 14 C- and 3 H-labeled L-prolyl-L-leucyl-glycinamide in the rat.
Topics: Adrenal Glands; Amides; Animals; Carbon Isotopes; Glycine; Half-Life; Hypothalamus; Kidney; Leucine; Liver; Melanocyte-Stimulating Hormones; Muscles; Pineal Gland; Pituitary Gland; Plasma Volume; Proline; Rats; Tritium | 1973 |
Basic proteins in neurons containing fibrillary deposits.
Topics: Aluminum; Amino Acids; Animals; Arginine; Brain; Cell Membrane; Centrifugation, Density Gradient; Leucine; Lipid Metabolism; Lysine; Male; Membrane Potentials; Microscopy, Electron; Nerve Tissue Proteins; Neurofibrils; Neurons; Phosphates; Proline; Rabbits; Spinal Cord; Tritium | 1973 |
Inhibition of intestinal amino acid transport by blood sugar lowering biguanides.
Topics: Amino Acids; Animals; Biguanides; Biological Transport, Active; Carbon Isotopes; Cricetinae; Glycine; In Vitro Techniques; Intestine, Small; Leucine; Lysine; Methionine; Proline; Time Factors | 1973 |
Isolation of active messenger RNA for s casein from bound polyribosomes of mammary gland.
Topics: Animals; Antibodies; Carbon Isotopes; Caseins; Cell-Free System; Centrifugation, Density Gradient; Electrophoresis, Polyacrylamide Gel; Female; Guinea Pigs; Isoleucine; Leucine; Mammary Glands, Animal; Peptides; Polyribosomes; Proline; Protein Biosynthesis; Reticulocytes; RNA, Messenger; Sheep; Sodium Dodecyl Sulfate; Sucrose; Time Factors; Tritium | 1973 |
The reversal of triparanol-induced cataracts in the rat. 3. Amino acid content and uptake of 14 C -AIB in cataractous and clearing lenses.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Cataract; Cystine; Diet; Glutamates; Glycine; Histidine; Isoleucine; Lens, Crystalline; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rats; Serine; Threonine; Triparanol; Tyrosine; Valine | 1973 |
Synthesis of soluble neuronal proteins in vivo. Age-dependent differences in the incorporation of leucine and phenylalanine.
Topics: Age Factors; Animals; Carbon Isotopes; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Leucine; Male; Microtubules; Nerve Tissue Proteins; Phenylalanine; Proline; Rats; Tritium; Vinblastine | 1973 |
A cerebello-olivary pathway in the cat: an experimental study using autoradiographic tracing technics.
Topics: Animals; Autoradiography; Cats; Cerebellar Nuclei; Cerebellum; Leucine; Neural Pathways; Olivary Nucleus; Proline; Tritium | 1973 |
Reiteration of DNA complementary to a cytoplasmic non-ribosomal RNA.
Topics: Adenine Nucleotides; Animals; Carrageenan; Collagen; DNA; Granuloma; Guinea Pigs; Kinetics; Leucine; Liver; Nucleic Acid Hybridization; Phosphates; Phosphorus Radioisotopes; Polynucleotides; Proline; Ribonucleases; RNA; Tritium | 1973 |
Sarcosine and imino acid uptake in Saccharomyces chevalieri. Derepression by nitrogen starvation.
Topics: Acridines; Aerobiosis; Anaerobiosis; Azetines; Biological Transport; Carbon Radioisotopes; Cycloheximide; Diamines; Fungal Proteins; Hydroxyproline; Imino Acids; Isoleucine; Leucine; Nitrogen; Phenylalanine; Proline; RNA, Messenger; Saccharomyces; Sarcosine; Time Factors; Tritium; Tryptophan | 1973 |
Dopamine synthesis: stimulation by a hypothalamic factor.
Topics: Animals; Brain; Corpus Striatum; Dopamine; Glycine; Hypophysectomy; Hypothalamus; Leucine; Male; Melanocyte-Stimulating Hormones; Norepinephrine; Oligopeptides; Peptides; Proline; Rats; Stimulation, Chemical; Tissue Extracts; Tritium; Tyrosine | 1973 |
Deuteron magnetic resonance studies on the microdynamical behavior of partially deuterated oxytocin with neurophysin.
Topics: Chromatography, Gel; Chromatography, Thin Layer; Circular Dichroism; Deuterium; Electrophoresis, Polyacrylamide Gel; Glycine; Leucine; Magnetic Resonance Spectroscopy; Mathematics; Neurophysins; Oligopeptides; Oxytocin; Proline; Spectrophotometry, Ultraviolet | 1973 |
The metabolism of amino acids in the bovine lens. Their oxidation as a source of energy.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Carbon Dioxide; Carbon Radioisotopes; Cattle; Collagen; Energy Metabolism; Glucose; Glutamates; Glutathione; In Vitro Techniques; Lactates; Lens, Crystalline; Leucine; Lipid Metabolism; Lysine; Oxidation-Reduction; Proline; Serine; Taurine; Tryptophan; Tyrosine | 1973 |
Biosynthetic precursors of etamycin, a peptidolactone antibiotic from Streptomyces griseoviridus.
Topics: Alanine; Anti-Bacterial Agents; Benzene Derivatives; Carbon Radioisotopes; Glucose; Hydroxyproline; Lactones; Leucine; Lysine; Nitrates; Peptides, Cyclic; Picolinic Acids; Potassium; Proline; Sarcosine; Streptomyces; Structure-Activity Relationship; Threonine; Tritium | 1973 |
Fatty acid inhibition of somatomedin (serum sulfation factor)-stimulated protein and RNA synthesis in embryonic chicken cartilage.
Topics: Amino Acids; Animals; Butyrates; Caprylates; Cartilage; Chick Embryo; Chondroitin; Chromatography; Chromatography, Ion Exchange; Collagen; Culture Media; Hydroxyproline; Leucine; Mucoproteins; Polysaccharides; Proline; Protein Biosynthesis; Rats; RNA; Somatomedins; Sulfur Radioisotopes; Sulfuric Acids; Tritium; Tryptophan; Uridine | 1973 |
Tris(hydroxymethyl)aminomethane buffer and amino acid analysis.
Topics: Amino Acids; Buffers; Chromatography; Indicators and Reagents; Leucine; Methods; Proline; Spectrophotometry; Tromethamine; Valine | 1973 |
L-prolyl-L-leucyl-glycinamide (PLG): influences on locomotor and stereotyped behavior of cats.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Glycine; Humans; Leucine; Locomotion; Melanocyte-Stimulating Hormones; Oligopeptides; Proline; Stereotyped Behavior | 1973 |
[Effect of the set of amino acids contained in casein, extracted soy bean meal, horse beans and wheat gluten on the content of leucine, isoleucine, valine, phenylalanine, tyrosine, glutamic acid, aspartic acid, alanine, glycine and proline in the deprotei
Topics: Alanine; Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Caseins; Chickens; Female; Glutamates; Glutens; Glycine; Glycine max; Isoleucine; Leucine; Phenylalanine; Plant Proteins; Proline; Triticum; Tyrosine; Valine | 1973 |
Regulation of amino acid transport in kidney cortex of newborn rats.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Animals, Newborn; Carbon Radioisotopes; Cycloheximide; Cyclopentanes; Dactinomycin; Depression, Chemical; Glycine; In Vitro Techniques; Kidney Cortex; Kinetics; Leucine; Lysine; Methylglycosides; Proline; Rats; Temperature; Valine | 1974 |
Folding of polypeptide chains induced by the amino acid side-chains.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Glycine; Leucine; Peptide Chain Elongation, Translational; Peptides; Phenylalanine; Probability; Proline; Protein Conformation; Structure-Activity Relationship | 1974 |
The nature of hypthalamo-neurohypophyseal neurosecretion in the rat. A study by light- and electron microscope autoradiography.
Topics: Animals; Autoradiography; Cystine; Ethyl Ethers; Histocytochemistry; Hypothalamus; Isotope Labeling; Leucine; Microscopy, Electron; Neurophysins; Pituitary Gland, Posterior; Proline; Rats; Silver; Subcellular Fractions; Time Factors; Tritium | 1974 |
The specification of the retino-tectal projection in the chick.
Topics: Animals; Autoradiography; Brain Mapping; Chick Embryo; Chickens; Leucine; Proline; Retina; Superior Colliculi; Tritium | 1974 |
Thalamic organization of the retino-thalamo-hyperstriatal pathway in the pigeon (Columba livia).
Topics: Animals; Autoradiography; Brain Mapping; Columbidae; Fucose; Leucine; Neural Pathways; Proline; Retina; Telencephalon; Thalamic Nuclei; Tritium | 1974 |
Intracellular free amino acid concentration in human muscle tissue.
Topics: Adult; Alanine; Amino Acids; Arginine; Asparagine; Biopsy, Needle; Body Water; Chlorides; Citrulline; Extracellular Space; Female; Glutamates; Glutamine; Glycine; Histidine; Humans; Isoleucine; Leucine; Lipid Metabolism; Male; Muscles; Ornithine; Phenylalanine; Proline; Serine; Taurine; Tyrosine; Valine | 1974 |
Quantitative evaluation of nonspecific nitrogen sources for the growing chick.
Topics: Amino Acids, Essential; Animals; Arginine; Body Composition; Body Water; Body Weight; Chickens; Citrates; Glutamates; Glycine; Isoleucine; Leucine; Lysine; Male; Nitrogen; Proline; Quaternary Ammonium Compounds; Urea; Valine | 1974 |
Changes in the concentration of free amino acids in the haemolymph of Rhodnius prolixus during the fifth instar.
Topics: Amino Acids; Animals; Hemolymph; Histidine; Insecta; Leucine; Metamorphosis, Biological; Phenylalanine; Proline; Time Factors; Tyrosine | 1974 |
Oxotremorine antagonism by prolyl-leucyl-glycine-amide administered by different routes and with several anticholinergics.
Topics: Administration, Oral; Amides; Analysis of Variance; Animals; Behavior, Animal; Benztropine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Glycine; Injections, Intravenous; Injections, Subcutaneous; Leucine; Male; Mice; Mice, Inbred ICR; Oligopeptides; Oxotremorine; Parasympatholytics; Proline; Scopolamine; Time Factors; Trihexyphenidyl | 1974 |
Transport of L-methionine in rat intestine and kidney.
Topics: Anaerobiosis; Animals; Biological Transport, Active; Carbon Radioisotopes; Chromatography; Culture Media; Depression, Chemical; Ethionine; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Mucosa; Intestines; Kidney Cortex; Leucine; Lysine; Male; Methionine; Proline; Sodium; Sucrose; Tryptophan; Valine | 1974 |
Cell-free protein synthesis by rat brain in triethyl tin intoxication.
Topics: Animals; Brain Edema; Carbon Radioisotopes; Cerebral Cortex; Corpus Callosum; Depression, Chemical; Female; Injections, Intraperitoneal; Leucine; Male; Proline; Subcellular Fractions; Time Factors; Tin | 1974 |
[Multiplicity of transport systems in the luminal membrane of the nephron in the normal rat].
Topics: Alanine; Animals; Biological Transport; Carbon Radioisotopes; Female; Glycine; Hydroxyproline; Imino Acids; Inulin; Kidney; Leucine; Membranes; Nephrons; Phenylalanine; Proline; Rats | 1974 |
[Synthesis of radioactive potential precursers of peptide moieties of ergotoxine alkaloids].
Topics: Alanine; Carbon Radioisotopes; Cyclization; Ergolines; Ergot Alkaloids; Esters; Glycine; Isotope Labeling; Lactams; Leucine; Methods; Peptides; Proline; Valine | 1974 |
In vitro synthesis of collagen peptides on fetal and neonatal rat skin polysomes by rabbit reticulocyte initiation factors.
Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Collagen; Female; Fetus; Leucine; Peptide Biosynthesis; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Polyribosomes; Pregnancy; Proline; Protein Biosynthesis; Rabbits; Rats; Reticulocytes; Skin; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1974 |
The mean geometry of the peptide unit from crystal structure data.
Topics: Acetamides; Alanine; Crystallography; Glutathione; Glycine; Leucine; Models, Structural; Molecular Conformation; Oligopeptides; Phenylalanine; Proline; Protein Conformation; Tyrosine; X-Ray Diffraction | 1974 |
DOPA potentiation in ablated animals and brain levels of biogenic amines in intact animals after prolyl-leucylglycinamide.
Topics: Administration, Oral; Adrenal Glands; Amides; Animals; Behavior, Animal; Biogenic Amines; Brain; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Female; Glycine; Homovanillic Acid; Kidney; Leucine; Male; Mice; Norepinephrine; Ovary; Parathyroid Glands; Pargyline; Peptides; Proline; Rats; Serotonin; Spleen; Stimulation, Chemical; Testis; Thymus Gland | 1974 |
Studies on the synthesis of amino acids by Mycobacteria. I. Incorporation of 14C carbon in the form of acetate into amino acids of tubercle bacilli.
Topics: Acetates; Amino Acids; Arginine; Aspartic Acid; Autoradiography; Carbon Isotopes; Chromatography; Densitometry; Glutamates; Isoleucine; Leucine; Mycobacterium bovis; Proline | 1967 |
Mode of action of enomycin, an antitumor antibiotic of high molecular weight. I. Inhibition of protein synthesis.
Topics: Animals; Antibiotics, Antineoplastic; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Escherichia coli; HeLa Cells; In Vitro Techniques; Leucine; Liver; Lysine; Magnesium; Mice; Phenylalanine; Polynucleotides; Proline; Protein Biosynthesis; Rats; RNA, Messenger; RNA, Transfer; Thymidine; Time Factors; Uridine | 1967 |
Formation of filaments and synthesis of macromolecules at temperatures below the minimum for growth of Escherichia coli.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Division; DNA, Bacterial; Escherichia coli; Leucine; Microscopy, Electron; Microscopy, Phase-Contrast; Pimelic Acids; Proline; RNA, Bacterial; Temperature; Thymine; Tritium; Uracil | 1968 |
Bovine pepsinogen and pepsin. I. Isolation, purification, and some properties of the pepsinogen.
Topics: Abomasum; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Electrophoresis, Disc; Enzyme Precursors; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Molecular Weight; Pepsin A; Proline; Swine; Tryptophan; Ultracentrifugation | 1968 |
Mechanism of action of bottromycin in polypeptide biosynthesis.
Topics: Anti-Bacterial Agents; Carbon Isotopes; Cell-Free System; Centrifugation, Density Gradient; Chloramphenicol; Dialysis; Escherichia coli; Leucine; Peptides; Phenylalanine; Proline; Protein Binding; Puromycin; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Serine; Valine | 1968 |
An application of diagonal electrophoresis to the selective purification of serine phosphate peptides. Serine phosphate peptides from ovalbumin.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Chymotrypsin; Electrophoresis; Isoleucine; Leucine; Lysine; Ovalbumin; Pepsin A; Peptides; Proline; Serine; Trypsin | 1968 |
The amino acid sequences of some tryptic peptides from porcine pepsinogen.
Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Asparagine; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Enzyme Precursors; Glycine; Histidine; Leucine; Lysine; Pepsin A; Peptides; Proline; Swine; Trypsin; Valine | 1968 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
[Study of the inactivation of the acceptor properties of transfer ribonucleic acids by ionizing radiation].
Topics: Alkaline Phosphatase; Amino Acids; Carbon Isotopes; Chromatography; Cobalt Isotopes; Escherichia coli; Esters; Isoleucine; Leucine; Phenylalanine; Phosphates; Proline; Radiation Effects; RNA, Transfer; Saccharomyces; Serine; Solutions; Spectrophotometry; Water | 1968 |
Aminoacyl transfer ribonucleic acid synthetases from cell-free extract of Plasmodium berghei.
Topics: Acridines; Amino Acids; Carbon Isotopes; Cell-Free System; Escherichia coli; Genetic Code; Histidine; Leucine; Ligases; Liver; Lysine; Plasmodium; Proline; Pyrimethamine; Quinacrine; RNA, Transfer; Species Specificity; Stilbamidines; Threonine; Tyrosine; Valine | 1969 |
Arginine transport and metabolism in osmotically shocked and unshocked cells of Escherichia coli W.
Topics: Acetates; Arginine; Biological Transport; Canavanine; Carbon Isotopes; Carboxy-Lyases; Citrulline; Cold Temperature; Escherichia coli; Glutamates; Guanidines; Hydrochloric Acid; Leucine; Lysine; Ornithine; Osmolar Concentration; Proline; Tromethamine; Urea | 1969 |
Amino acid antagonist death in Escherichia coli.
Topics: Amino Acids; Escherichia coli; Leucine; Microscopy, Electron; Proline; Threonine; Tryptophan | 1969 |
A simple procedure for fractionation of transfer RNA.
Topics: Albumins; Cellulose; Chromatography; Escherichia coli; Filtration; Histidine; Leucine; Lysine; Membranes, Artificial; Methionine; Methods; Phenylalanine; Proline; RNA, Bacterial; RNA, Transfer; Time Factors; Tritium; Tyrosine | 1970 |
[Use of the replication method for obtaining bacteria of the E. coli group resistant and sensitive to antibiotics].
Topics: Animals; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections; Genetics, Microbial; Leucine; Mice; Microbial Sensitivity Tests; Mutation; Proline; Recombination, Genetic; Shigella dysenteriae; Shigella sonnei; Streptomycin; Threonine | 1970 |
Substrate specificity of ribosomal peptidyl transferase. The effect of the nature of the amino acid side chain on the acceptor activity of 2'(3')-O-aminoacyladenosines.
Topics: Acetates; Acyltransferases; Alanine; Amino Acids; Binding Sites; Carbon Isotopes; Escherichia coli; Glutamine; Glycine; Imidazoles; Leucine; Lysine; Methionine; Nucleosides; Peptides; Phenylalanine; Proline; Ribosomes; RNA, Transfer; Serine; Stereoisomerism; Valine | 1970 |
Messenger and template activities of chemically modified polynucleotides.
Topics: Adenosine Triphosphate; Alkylating Agents; Carbon Isotopes; Cell-Free System; Cytosine Nucleotides; Escherichia coli; Guanidines; Guanine Nucleotides; Hydroxylamines; Leucine; Mutation; Nitrites; Nitroso Compounds; Phenylalanine; Polynucleotides; Proline; Radiation Effects; RNA Nucleotidyltransferases; RNA, Transfer; Serine; Templates, Genetic; Ultraviolet Rays; Uracil Nucleotides | 1970 |
Differential recovery of auxotrophs after penicillin enrichment in Escherichia coli.
Topics: Bacteriological Techniques; Culture Media; Escherichia coli; Genes; Genetics, Microbial; Hypertonic Solutions; Hypotonic Solutions; Leucine; Methionine; Mutation; Penicillin G; Proline | 1971 |
Incorporation of high molecular weight polynucleotides by isolated mitochondria.
Topics: Animals; Anura; Centrifugation, Density Gradient; Female; In Vitro Techniques; Leucine; Lysine; Methionine; Mitochondria; Molecular Weight; Ovary; Peptide Biosynthesis; Phenylalanine; Polynucleotides; Proline; Ribosomes; Stimulation, Chemical; Templates, Genetic; Tritium; Uracil Nucleotides | 1971 |
Synthesis and breakdown of proteins in Escherichia coli during amino-acid starvation.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chromatography, Gel; Escherichia coli; Galactosidases; Genetic Code; Leucine; Methionine; Molecular Weight; Peptides; Proline; Ribosomes; RNA, Messenger; Tritium | 1971 |
2'-O-Methyl polynucleotides as templates for cell-free amino acid incorporation.
Topics: Adenine Nucleotides; Amino Acids; Carbon Isotopes; Cell-Free System; Centrifugation, Density Gradient; Cytosine Nucleotides; Escherichia coli; Ethers; Genetic Code; Isoleucine; Kinetics; Leucine; Methanol; Methylation; Molecular Biology; Neomycin; Phenylalanine; Polynucleotides; Proline; Protein Biosynthesis; Ribonucleotides; RNA, Bacterial; Serine; Templates, Genetic; Tyrosine; Uracil Nucleotides | 1971 |
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.
Topics: Acetates; Amino Acid Sequence; Amino Acids; Anhydrides; Animals; Arginine; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Follicle Stimulating Hormone; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Hypothalamus; Leucine; Luteinizing Hormone; Mass Spectrometry; Methods; Naphthalenes; Peptides; Pituitary Hormone-Releasing Hormones; Proline; Serine; Sulfonic Acids; Swine; Thiocyanates; Tritium; Tryptophan; Tyrosine | 1971 |
Thiobacillus denitrificans as an obligate chemolithotroph. Isolation and growth studies.
Topics: Acetates; Anaerobiosis; Arginine; Bacteriological Techniques; Carbon; Carbon Isotopes; Culture Media; Glucose; Glutamates; Glycerides; Lactates; Leucine; Lipids; Manometry; Proline; Proteins; Pyruvates; Succinates; Thiobacillus; Thiosulfates | 1971 |
Methionineless death in Escherichia coli.
Topics: Amino Acyl-tRNA Synthetases; Arginine; Bacterial Proteins; Bacteriological Techniques; Carbon Isotopes; Cell Survival; Culture Media; Decarboxylation; DNA, Bacterial; Escherichia coli; Filtration; Isoleucine; Leucine; Methionine; Proline; Spermidine; Spermine; Thymine; Tryptophan; Uracil | 1971 |
Uptake of amino acids by actidione-treated yeast cells. I. Specificity of carriers.
Topics: Amino Acids; Arginine; Aspartic Acid; Binding Sites; Biological Transport; Carrier Proteins; Cell Membrane; Cycloheximide; Cysteine; Glutamates; Glycine; Histidine; Kinetics; Leucine; Lysine; Methionine; Proline; Protein Biosynthesis; Saccharomyces; Saccharomyces cerevisiae | 1971 |
The comparative biochemistry of the organic matrix proteins of developing enamel. I. Amino acid composition.
Topics: Amelogenesis; Amino Acids; Animals; Artiodactyla; Bicuspid; Cattle; Dental Enamel Proteins; Dogs; Female; Glutamates; Goats; Haplorhini; Histidine; Humans; In Vitro Techniques; Incisor; Leucine; Pregnancy; Pregnancy, Animal; Proline; Protein Binding; Sheep; Swine | 1967 |
Species specificity of sRNA's and aminoacyl-sRNA synthetases in some aerobic bacteria.
Topics: Alcaligenes; Amino Acids; Chromatography, Paper; Escherichia coli; Leucine; Ligases; Proline; Pseudomonas; Pseudomonas aeruginosa; RNA, Bacterial; RNA, Transfer; Saccharomyces; Valine | 1966 |
Species differences of serum amino acid beta-napthylamidases.
Topics: Alanine; Amides; Amino Acids; Aminopeptidases; Animals; Arginine; Chickens; Cyprinidae; Dipeptides; Dogs; Female; Glutamine; Glycine; Haplorhini; Humans; Isoleucine; Leucine; Lysine; Methionine; Mice; Naphthalenes; Phenylalanine; Proline; Rats; Serine; Species Specificity; Valine | 1968 |
Studies on the synthesis of amino acids by mycobacteria. II. Influence of amino acid content of the medium on the synthesis of amino acids of 14 c labeled tubercle bacilli.
Topics: Acetates; Amino Acids; Autoradiography; Carbon Isotopes; Caseins; Chromatography, Paper; Culture Media; Densitometry; Isoleucine; Leucine; Mycobacterium tuberculosis; Proline | 1967 |
"Dysgonic" strains of mycobacterium tuberculosis on Ogawa's egg medium isolated as pathogens from patients suffering from lung tuberculosis. II. Growth-inhibitory effects of D-asparagine, D-aspartic acid, Dl-serine, or L-serine against "dysgonic".
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Culture Media; Depression, Chemical; Glutamine; Histidine; Humans; Leucine; Mycobacterium tuberculosis; Proline; Serine; Tuberculosis, Pulmonary; Valine | 1967 |
Catabolite repression and feedback inhibition of protease in Streptococcus faecalis var. liquefaciens.
Topics: Amino Acids; Dipeptides; Enterococcus faecalis; Enzyme Repression; Feedback; Galactosidases; Isoleucine; Leucine; Peptide Hydrolases; Peptides; Phenylalanine; Proline; Tryptophan; Valine | 1968 |
o-Quinones formed in plant extracts. Their reactions with amino acids and peptides.
Topics: Amino Acids; Catechol Oxidase; Chemical Phenomena; Chemistry; Chlorogenic Acid; Cinnamates; Color; Cysteine; Glycine; Histidine; Hydrogen-Ion Concentration; Leucine; Lysine; Manometry; Nicotiana; Oxygen Consumption; Peptides; Plant Extracts; Plants; Plants, Toxic; Proline; Quinones; Spectrophotometry; Time Factors; Tryptophan | 1969 |
Influence of carbon or nitrogen starvation on amino acid transport in Pseudomonas aeruginosa.
Topics: Alanine; Amino Acids; Biological Transport; Carbon; Carbon Isotopes; Chloramphenicol; Glutamates; Glycine; Histidine; Leucine; Nitrogen; Proline; Pseudomonas aeruginosa; Valine | 1969 |
Plasma amino acid levels in diabetic ketoacidosis.
Topics: Adolescent; Adult; Aged; Alanine; Amino Acids; Arginine; Butyrates; Child; Citrulline; Cystine; Diabetic Ketoacidosis; Female; Glycine; Histidine; Humans; Insulin; Isoleucine; Leucine; Lysine; Male; Methionine; Middle Aged; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1970 |
Studies on the induction and repression of enzymes in rat liver. VI. Some properties and the metabolic regulation of two isozymic forms of serine dehydratase.
Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Chromatography, DEAE-Cellulose; Cortisone; Crystallization; Diabetes Mellitus, Experimental; Electrophoresis, Disc; Enzyme Induction; Glucagon; Hydro-Lyases; Immune Sera; Immunodiffusion; Isoenzymes; L-Serine Dehydratase; Leucine; Liver; Lysine; Male; Molecular Weight; Phosphates; Proline; Pyridoxal Phosphate; Rats; Spectrophotometry; Tritium; Ultraviolet Rays | 1971 |
Synthesis of analogs of the thyrotropin-releasing hormone and structure-activity relationship.
Topics: Alanine; Amides; Animals; Benzyl Compounds; Biological Assay; Esters; Histidine; Leucine; Magnetic Resonance Spectroscopy; Mice; Peptides; Proline; Pyrrolidinones; Thyrotropin; Thyrotropin-Releasing Hormone; Valine | 1971 |
Crystal structure and conformation of the cyclic dipeptide cyclo-L-prolyl-L-leucyl.
Topics: Amino Acid Sequence; Crystallography; Dipeptides; Leucine; Peptides, Cyclic; Proline; Protein Conformation; Structure-Activity Relationship | 1972 |
Brain peptidases: conversion and inactivation of kinin hormones.
Topics: Amino Acids; Animals; Arginine; Brain; Electrophoresis; Guinea Pigs; Ileum; Kinins; Leucine; Lysine; Methionine; Peptide Hydrolases; Proline; Rabbits | 1972 |
[On the incorporation of dipeptides in ergotoxin alcaloids].
Topics: Culture Techniques; Dipeptides; Ergot Alkaloids; Leucine; Proline; Toxins, Biological | 1972 |
Sow colostral free amino acids and their importance for the newborn piglet.
Topics: Amino Acids; Animals; Animals, Newborn; Colostrum; Female; Leucine; Pregnancy; Proline; Swine; Time Factors | 1972 |
Characteristics of amino acid accumulation by synaptosomal particles isolated from rat brain.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Brain; Carbon Isotopes; Leucine; Lysine; Nerve Endings; Ouabain; Potassium; Proline; Rats; Serine; Sodium; Stimulation, Chemical; Synaptic Vesicles; Synaptosomes; Threonine; Tyrosine; Valine | 1972 |
Regulation of amino acid transport in chick embryo heart cells. I. Adaptive system of mediation for neutral amino acids.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Cells; Chick Embryo; Cycloheximide; Cyclopentanes; Dactinomycin; Glycine; Heart; Kinetics; Leucine; Myocardium; Phenylalanine; Proline; Puromycin; Time Factors | 1972 |
Effects of phenothiazines on amino acid transport and protein synthesis in isolated nerve endings.
Topics: Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chlorpromazine; Kinetics; Leucine; Nerve Endings; Phenothiazines; Phenylalanine; Proline; Promazine; Protein Biosynthesis; Rats; Synaptosomes | 1972 |
Amino acid transport by rat small intestine. Galactose inhibition of transepithelial net transport as a result of stimulation of bidirectional efflux from the epithelium.
Topics: Animals; Biological Transport; Carbon Isotopes; Cell Membrane; Epithelial Cells; Epithelium; Galactose; Ileum; Ilium; Jejunum; Kinetics; Leucine; Male; Proline; Rats; Time Factors | 1972 |
A basis for the difference in the inhibition of the uptake of various neutral amino acids by lysine in intestinal epithelial cells.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Epithelial Cells; Epithelium; Histidine; Intestinal Mucosa; Intestines; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Rats; Sodium; Threonine; Tryptophan; Valine | 1972 |
[Phenotypic and genetic analysis of the "nutrient markers" of Staphylococcus aureus and their taxonomic significance].
Topics: Animals; Arginine; Cattle; Cysteine; Dogs; Genetics, Microbial; Genotype; Humans; Leucine; Methionine; Nicotinic Acids; Phenotype; Proline; Rabbits; Staphylococcus; Swine; Thiamine; Threonine; Transduction, Genetic; Valine | 1972 |
[Concentration changes of free amino acids in blood plasma of patients under radiotherapy. (With reference to statistical results)].
Topics: Alanine; Amino Acids; Bronchial Neoplasms; Carcinoma; Cobalt Isotopes; Dysgerminoma; Esophageal Neoplasms; Female; Genital Neoplasms, Female; Hodgkin Disease; Humans; Leucine; Male; Neoplasms; Phenylalanine; Proline; Radiation Injuries; Sex Factors; Statistics as Topic; Tyrosine; Urinary Bladder Neoplasms; Valine | 1972 |
Amino acid patterns in the blood plasma of the young bovine.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Cystine; Female; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1972 |
Purification and properties of glycylprolyl -naphthylamidase in human submaxillary gland.
Topics: Amidohydrolases; Ammonium Sulfate; Animals; Autolysis; Cattle; Cell Nucleus; Chromatography, Gel; Electrophoresis, Disc; Glycine; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Microsomes; Mitochondria; Molecular Weight; Naphthalenes; Proline; Solubility; Species Specificity; Structure-Activity Relationship; Submandibular Gland | 1972 |
Axonal transport in embryonic visual system in zebrafish.
Topics: Animals; Autoradiography; Axons; Cyprinidae; Inferior Colliculi; Leucine; Nerve Tissue Proteins; Proline; Superior Colliculi; Tritium; Visual Cortex; Visual Pathways | 1972 |
Transfer RNA changes in rat granulation tissue possibly related to collagen synthesis.
Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Cellulose; Chromatography, DEAE-Cellulose; Collagen; Glycine; Granulation Tissue; Leucine; Lysine; Male; Proline; Rats; RNA, Transfer; Serine; Time Factors; Tritium | 1972 |
Transport of amino acids into the oestrogen-primed uterus. Enchancement of the uptake by a preliminary incubation.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Dinitrophenols; Estradiol; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Leucine; Phenylalanine; Potassium; Proline; Rats; Sodium; Time Factors; Uterus; Valine | 1972 |
Haemoglobin Denmark Hill 95 (G2) Pro-Ala, a variant with unusual electrophoretic and oxygen-binding properties.
Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Electrophoresis, Paper; Electrophoresis, Starch Gel; Female; Gestational Age; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Leucine; London; Molecular Biology; Mutation; Oxygen; Peptides; Pregnancy; Proline; Protein Binding; Serine | 1972 |
Effect of excess levels of individual amino acids on growth of rats fed casein diets.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Caseins; Cystine; Depression, Chemical; Dietary Proteins; DNA; Glutamates; Glycine; Growth; Histidine; Isoleucine; Leucine; Liver; Lysine; Male; Methionine; Organ Size; Phenylalanine; Proline; Proteins; Rats; RNA; Serine; Stereoisomerism; Stimulation, Chemical; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
Effect of dietary protein level on plasma free amino acids in the chicken.
Topics: Alanine; Amino Acids; Animals; Blood; Body Weight; Caseins; Chickens; Depression, Chemical; Dietary Proteins; Glycine; Isoleucine; Leucine; Lysine; Male; Methionine; Proline; Proteins; Serine; Stimulation, Chemical; Threonine; Tyrosine; Valine | 1971 |
Quantitative changes in plasma amino acids induced by oral contraceptives.
Topics: Adult; Alanine; Amino Acids; Contraceptives, Oral; Female; Glutamine; Glycine; Gonadal Steroid Hormones; Humans; Isoleucine; Leucine; Ornithine; Ovulation; Proline; Serine; Tyrosine; Valine | 1971 |
Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy. Preliminary report.
Topics: Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Arginine; Aspartic Acid; Citrulline; Cystine; Female; Gestational Age; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Proline; Serine; Threonine; Tyrosine; Valine | 1971 |
Incorporation in vitro of ( 14 C)leucine into the mitochondrial protein of Lucilia cuprina. 2. Energy requirements.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diptera; Germ-Free Life; In Vitro Techniques; Isoleucine; Leucine; Mitochondria, Muscle; Oligomycins; Oxygen Consumption; Proline; Protein Biosynthesis; Valine | 1971 |
Amino acid immobilization of fungal motile cells.
Topics: Amino Acids; Cell Count; Culture Media; Drug Synergism; Eukaryota; Fungi; Immobilization; Isomerism; Leucine; Lysine; Proline; Spores; Time Factors | 1971 |
Studies on the conformation of amino acids. VI. Conformation of the proline ring as observed in crystal structures of amino acids and peptides.
Topics: Amino Acids; Benzyl Compounds; Bromine; Chemical Phenomena; Chemistry, Physical; Copper; Crystallography; Cyclopentanes; Dipeptides; Formates; Glycine; Hydroxyproline; Leucine; Models, Structural; Peptides; Phenylalanine; Proline; Sulfonic Acids; Toluene | 1971 |
Acidic and basic amino acid transport systems of Penicillium chrysogenum.
Topics: Adipates; Aminobutyrates; Arginine; Aspartic Acid; Biological Transport; Carbon Isotopes; Chromatography, Paper; Cycloheximide; Feedback; Glutamates; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Membrane Transport Proteins; Methionine; Ornithine; Osmolar Concentration; Penicillium; Phenylalanine; Proline; Sodium Chloride; Temperature | 1971 |
The effect of dietary fluoride on plasma free amino acid concentrations in the rat.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Diet; Feeding Behavior; Female; Fluorides; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rats; Rats, Inbred Strains; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
Quantitative determination of intestinal peptide hydrolase activity using L-amino acid oxidase.
Topics: Amino Acid Oxidoreductases; Animals; Celiac Disease; Child; Diarrhea; Dipeptides; Glycoside Hydrolases; Guinea Pigs; Humans; Intestinal Mucosa; Intestines; Isoleucine; Kinetics; Lactose; Leucine; Mathematics; Methionine; Peptide Hydrolases; Peroxidases; Phenylalanine; Proline; Spectrophotometry | 1971 |
Stimulation of basic amino acid uptake by certain neutral amino acids in isolated intestinal epithelial cells.
Topics: Alanine; Animals; Arginine; Biological Transport; Biological Transport, Active; Carbon Isotopes; Depression, Chemical; Epithelial Cells; Epithelium; Glycine; Histidine; Hydrochloric Acid; Intestinal Mucosa; Intestines; Inulin; Isoleucine; Kinetics; Leucine; Lysine; Male; Mathematics; Methionine; Ornithine; Phenylalanine; Proline; Rats; Rats, Inbred Strains; Serous Membrane; Sodium; Stimulation, Chemical; Tritium; Tryptophan; Valine | 1971 |
Microdegradation procedure for radioactive peptide ergot alkaloids.
Topics: Amino Acids; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Dinitrophenols; Ergolines; Ergot Alkaloids; Hydrolysis; Keto Acids; Leucine; Peptides; Proline; Pyruvates; Valine | 1971 |
Application of gas-liquid radiochromatography to determination of the optical purity of carbon-14 labeled amino acids.
Topics: Alanine; Amino Acids; Carbon Isotopes; Chlorella; Chromatography, Gas; Cold Temperature; Drug Stability; Leucine; Methods; Proline; Serine; Stereoisomerism; Time Factors; Valine | 1971 |
[Antineoplastic effect and chemical structure of protamines of various origin].
Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Carcinoma, Ehrlich Tumor; Depression, Chemical; Fishes; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Leucine; Leukemia, Experimental; Lysine; Methionine; Mice; Proline; Protamines; Sarcoma 37; Serine; Threonine | 1971 |
Studies of intestinal transport defect in Hartnup disease.
Topics: Adolescent; Biological Transport; Carbon Isotopes; Child; Culture Techniques; Feces; Genes, Recessive; Hartnup Disease; Humans; Intellectual Disability; Intestinal Mucosa; Jejunum; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Tryptophan | 1971 |
Transport interaction of sugars and amino acids in mammalian kidney.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Depression, Chemical; Extracellular Space; Glycine; Glycosides; Histidine; In Vitro Techniques; Inulin; Kidney; Kinetics; Leucine; Lysine; Mathematics; Methionine; Proline; Rats; Tryptophan; Valine | 1971 |
Biosynthesis of peptide-type ergot alkaloids. Ergocornine and ergocryptine.
Topics: Claviceps; Ergot Alkaloids; Hydroxy Acids; Leucine; Lysergic Acid; Proline; Pyruvates; Stereoisomerism; Valine | 1971 |
Comparison of invariant residues in the variable and constant regions of human K, human L, and mouse K Bence-Jones proteins.
Topics: Amino Acid Sequence; Animals; Bence Jones Protein; Cysteine; Glutamates; Histidine; Humans; In Vitro Techniques; Leucine; Lysine; Mice; Phenylalanine; Proline; Serine; Tryptophan; Valine | 1967 |
The influence of short-range interactions on protein conformation. I. Side chain-backbone interactions within a single peptide unit.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Binding Sites; Cystine; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Kinetics; Leucine; Lysine; Methionine; Muramidase; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1968 |
Membranes of animal cells. 3. Amino acid incorporation by isolated surface membranes.
Topics: Amino Acids; Animals; Carbon Isotopes; Cell Membrane; Electrophoresis; Fibroblasts; L Cells; Leucine; Mice; Microsomes; Proline; RNA; Surface Properties; Tyrosine | 1969 |
Isoaccepting transfer RNA's of L-M cells in culture and after tumor induction in C3H mice.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Cell Line; Chromatography; Connective Tissue; Culture Media; Culture Techniques; Female; Fibrosarcoma; Glycine; Histidine; Isoleucine; Leucine; Ligases; Lysine; Male; Methionine; Mice; Phenylalanine; Proline; RNA, Transfer; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
Transfer RNA species in normal and leukemic human lymphoblasts.
Topics: Amino Acids; Carbon Isotopes; Cell Line; Chromatography; Glutamine; Glycine; Humans; Leucine; Leukemia, Lymphoid; Ligases; Lymphocytes; Proline; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine | 1970 |
A comparative study of x-ray diffraction and infrared absorption properties and amino-acid analysis of bovine enamel.
Topics: Amino Acids; Ammonia; Animals; Apatites; Arginine; Cattle; Crystallization; Dental Enamel; Glutamates; Glycine; Hydroxyproline; Infrared Rays; Leucine; Lysine; Odontogenesis; Proline; Spectrum Analysis; X-Ray Diffraction | 1971 |
Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone.
Topics: Animals; Endopeptidases; Estrus; Female; Glycine; Hypothalamus; Leucine; Male; Melanocyte-Stimulating Hormones; Microsomes; Mitochondria; Oxytocin; Peptide Biosynthesis; Peptides; Pituitary Gland; Pregnancy; Proline; Rats; Vasopressins | 1971 |
[Distribution of free amino acids in plasma in patients with a chronic lymphatic and acute leukemia].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Citrulline; Cystine; Glutamates; Glutamine; Glycine; Histidine; Humans; Isoleucine; Leucine; Leukemia, Lymphoid; Lysine; Methionine; Ornithine; Phenylalanine; Prednisolone; Proline; Serine; Threonine; Triethylenemelamine; Tyrosine; Valine; Vincristine | 1971 |
Inhibition of MSH release in frogs by direct application of L-proplyl-L-leucylglycinamide to the pituitary.
Topics: Animals; Anura; Biological Assay; Blood; Cell Aggregation; Dopamine; Epinephrine; Glycine; Heparin; Hypothalamus; Leucine; Male; Melanocyte-Stimulating Hormones; Melanocytes; Melatonin; Norepinephrine; Peptides; Pigmentation; Pituitary Gland; Proline; Rana pipiens | 1971 |
A preliminary map of genomic sites for F-attachment in Escherichia coli K12.
Topics: Adenine; Arginine; Chromosome Mapping; Chromosomes; Escherichia coli; Galactose; Histidine; In Vitro Techniques; Isoleucine; Lactose; Leucine; Lysine; Maltose; Mutation; Proline; Thiamine; Tryptophan | 1964 |
Degeneracy in the amino acid code.
Topics: Amino Acids; Asparagine; Bacterial Proteins; Escherichia coli; Genetic Code; Glutamine; Histidine; Leucine; Lysine; Polynucleotides; Proline; Serine; Threonine | 1966 |
Imidazolylacetolphosphate:L-glutamate aminotransferase. Composition and substructure.
Topics: Alanine; Ammonia; Arginine; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Electrophoresis; Genes; Glycine; Histidine; Leucine; Methionine; Molecular Biology; Molecular Weight; Peptides; Phenylalanine; Proline; Salmonella typhimurium; Serine; Threonine; Transaminases; Tyrosine; Valine | 1967 |
Inhibition of protein synthesis by bottromycin A2 and its hydrazide.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Cytosine Nucleotides; Escherichia coli; Hydrazines; Leucine; Lysine; Phenylalanine; Polynucleotides; Proline; Valine | 1966 |
Inhibition by mikamycins of polypeptide synthesis directed by native messengers and synthetic polynucleotides.
Topics: Animals; Anti-Bacterial Agents; Escherichia coli; In Vitro Techniques; Leucine; Liver; Lysine; Peptide Biosynthesis; Phenylalanine; Polynucleotides; Proline; Rats; Ribosomes; RNA, Transfer | 1966 |
Isolation and properties of subunits of bovine pituitary luteinizing hormone.
Topics: Amino Acids; Animals; Antigens; Arginine; Biological Assay; Carbohydrates; Carboxypeptidases; Cattle; Chromatography, Gel; Countercurrent Distribution; Dextrans; Diffusion; Electrophoresis, Disc; Immune Sera; Leucine; Luteinizing Hormone; Lysine; Methods; Molecular Weight; Pituitary Gland; Proline; Radioimmunoassay | 1969 |
[Transport of amino acids across lymphocyte membrane in human peripheral blood].
Topics: Amino Acids; Aspartic Acid; Biological Transport, Active; Cell Membrane; Glycine; Humans; Kinetics; Leucine; Lymphocytes; Lysine; Methionine; Proline; Radioisotopes; Serine; Temperature | 1969 |
Mass spectrometry of phenylthiohydantoin (PTH) amino acids.
Topics: Alanine; Amino Acids; Chromatography, Gas; Isoleucine; Leucine; Proline; Spectrum Analysis; Valine | 1969 |
Isosmotic regulation in isolated surviving nerves of Eriocheir sinensis Milne Edwards.
Topics: Adaptation, Physiological; Amino Acids; Ammonia; Animals; Cell Membrane Permeability; Crustacea; Hypotonic Solutions; Isoleucine; Leucine; Neurons; Osmotic Pressure; Phenylalanine; Proline; Seawater; Tyrosine; Valine; Water-Electrolyte Balance | 1969 |
[Chemical and physico-chemical properties of placental protein with antineoplastic effect].
Topics: Alanine; Amino Acids; Ammonia; Antineoplastic Agents; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Electrophoresis; Female; Glutamates; Glycine; Histidine; Humans; Leucine; Lysine; Phenylalanine; Placenta; Proline; Proteins; Serine; Threonine; Tyrosine; Valine | 1969 |
Free amino acids in plasma, red cells and anaplasmata of parasitized calves.
Topics: Amino Acids; Aminobutyrates; Anaplasma; Anaplasmosis; Animals; Arginine; Aspartic Acid; Cattle; Cattle Diseases; Chromatography, Ion Exchange; Chromatography, Thin Layer; Erythrocytes; Glycine; Isoleucine; Leucine; Ornithine; Proline; Spleen; Splenectomy; Threonine | 1969 |
Multiple forms of dipeptidases in normal human intestinal mucosa and in mucosa from children with coeliac disease.
Topics: Amino Acid Oxidoreductases; Amino Acids; Animals; Biopsy; Celiac Disease; Child; Coloring Agents; Diarrhea; Dipeptidases; Dipeptides; Electrophoresis; Glutamate Dehydrogenase; Humans; Intestinal Mucosa; Jejunum; Leucine; Methods; Peptide Hydrolases; Proline; Snakes | 1969 |
[On the influence of contraceptive pills on serum amino acids in comparison with results typical for sex, menstrual cycle and pregnancy].
Topics: Adult; Alanine; Amino Acids; Citric Acid Cycle; Contraceptives, Oral; Female; Glycine; Humans; Isoleucine; Leucine; Male; Menstruation; Methionine; Pregnancy; Proline; Sex Factors; Threonine; Tyrosine; Urea; Valine | 1969 |
Proline transport into isolated rat glomeruli.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Choline; Cyanides; Dinitrophenols; Female; Freezing; Hot Temperature; Hydroxyproline; In Vitro Techniques; Iodoacetates; Kidney Glomerulus; Kinetics; Leucine; Ouabain; Proline; Rats | 1970 |
Amino acid transport into human platelets and subsequent incorporation into protein.
Topics: Amino Acids; Biological Transport; Blood Platelets; Blood Proteins; Carbon Isotopes; Cell Membrane; Cysteine; Fibrin; Fibrinogen; Glutamates; Humans; Leucine; Lysine; Microscopy, Electron; Mitochondria; Proline; Puromycin; Serine; Thrombin; Valine | 1970 |
A comparative study of the ultrastructure and lack of growth capacity of adult human prostate epithelium mechanically separated from its stroma.
Topics: Adult; Autoradiography; Culture Techniques; Endoplasmic Reticulum; Epithelial Cells; Humans; Leucine; Male; Microscopy, Electron; Mitochondria; Proline; Prostate; Ribosomes; Uridine | 1970 |
Derivation of partial sequence of human beta chain messenger RNA from mutation data.
Topics: Alanine; Arginine; Genetic Code; Glycine; Hemoglobins; Humans; Leucine; Mutation; Nucleotides; Proline; RNA, Messenger; Serine; Threonine; Valine | 1970 |
Hemoglobin G Georgia or alpha 2-95 Leu (G-2) beta-2.
Topics: Amino Acid Sequence; Amino Acids; Black or African American; Child; Chromatography, Ion Exchange; Electrophoresis; Erythrocyte Count; Erythrocytes; Georgia; Globins; Hematocrit; Hemoglobins; Hemoglobins, Abnormal; Humans; Leucine; Male; Peptides; Proline; Trypsin | 1970 |
The intestinal absorption of some essential and non-essential amino acids in fed and fasting rats.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Carbon Isotopes; Deficiency Diseases; Fasting; Glycine; Histidine; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Male; Methionine; Proline; Rats | 1970 |
Prediction and explanation of chemical mutation sites.
Topics: Arginine; Asparagine; Genetic Code; Genetics, Microbial; Glycine; Leucine; Models, Chemical; Mutagens; Mutation; Nucleotides; Phenylalanine; Proline; RNA, Viral; Serine; Tobacco Mosaic Virus | 1970 |
[Study of chemical composition and antineoplastic effect of protamines isolated from the milt of sturgeon fishes].
Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Chromatography, Thin Layer; Depression, Chemical; Electrophoresis; Fishes; Glutamates; Glycine; Histidine; Leucine; Lysine; Male; Methionine; Mice; Molecular Weight; Neoplasms, Experimental; Nucleic Acids; Proline; Protamines; Sarcoma 37; Serine; Spectrum Analysis; Sulfates; Threonine; Ultraviolet Rays | 1970 |
Inhibition of Walker 256 intramuscular carcinoma in rats by administration of L-tryptophan.
Topics: Animals; Carcinoma 256, Walker; Female; Gluconeogenesis; Histidine; Injections, Intraperitoneal; Leucine; Male; Mice; Phenylalanine; Proline; Rats; Tryptophan | 1970 |
Changes in intestinal dipeptidase activities during fetal and neonatal development of the pig as related to the ultrastructure of mucosal cells.
Topics: Age Factors; Animals; Animals, Newborn; Cell Differentiation; Dipeptidases; Glutamine; Hydrogen-Ion Concentration; Intestinal Mucosa; Intestine, Small; Leucine; Microscopy, Electron; Proline; Swine | 1970 |
The venous plasma free amino acid levels during the first hours of life. II. In a lower socio-economic group of a refugee area in Karachi, West Pakistan, with special reference to the "small for dates" syndrome.
Topics: Alanine; Amino Acids; Birth Weight; Gestational Age; Glycine; Growth; Growth Disorders; Humans; Infant, Newborn; Leucine; Pakistan; Proline; Protein Deficiency; Socioeconomic Factors; Time Factors; Valine; Veins; White People | 1970 |
Gas-liquid chromatography and mass spectrometry of deuterium-containing amino acids as their trimethylsilyl derivatives.
Topics: Alanine; Amino Acids; Asparagine; Chromatography, Gas; Deuterium; Glycine; Leucine; Methionine; Proline; Silicon; Spectrum Analysis; Tyrosine; Valine | 1970 |
Changes in the concentration of specific amino acids in the serum of experimentally malnourished pigs.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Dietary Proteins; Female; Gluconeogenesis; Glycine; Histidine; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Protein Deficiency; Serine; Swine; Threonine; Tyrosine; Valine | 1970 |
Insulin and protein synthesis in muscle.
Topics: Amino Acids; Animals; Biological Transport; Carbon Isotopes; In Vitro Techniques; Insulin; Leucine; Male; Muscle Proteins; Muscles; Osmolar Concentration; Proline; Rats; Sodium | 1970 |
Incorporation of leucine-14C and lysine-14C into protein in the developing endosperm of normal and opaque-2 corn.
Topics: Albumins; Carbon Isotopes; Glutamates; Leucine; Lysine; Plant Proteins; Plants; Proline; Seeds; Zea mays | 1970 |
Metabolism of amino acids in incubated slices of mouse brain.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Brain; Carbon Isotopes; Centrifugation; Cerebellum; Cerebral Cortex; Chromatography, Paper; Glucose; Histidine; In Vitro Techniques; Leucine; Lysine; Medulla Oblongata; Mesencephalon; Mice; Oxygen Consumption; Phenylalanine; Pons; Proline; Valine | 1970 |
Loss of proteins and other macromolecules during preparation of cell cultures for high resolution autoradiography. Quantitation by a micromethod.
Topics: Aldehydes; Autoradiography; Cell Count; Cell Line; Choriocarcinoma; Culture Techniques; Female; Formaldehyde; Humans; Leucine; Macromolecular Substances; Methods; Microscopy, Electron; Neoplasm Proteins; Pregnancy; Proline; Protein Hydrolysates; Tritium | 1970 |
Determination of pico-mole quantities of gamma-amino-butyric acid (GABA) and serotonin.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoradiography; Brain Chemistry; Carbon Isotopes; Cerebellum; Chromatography; Cysteine; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methods; Microchemistry; Phenylalanine; Proline; Radionuclide Imaging; Rats; Serine; Serotonin; Threonine; Tyrosine; Valine | 1970 |
Amino acid permeability of pea chloroplasts as measured by osmotically determined reflection coefficients.
Topics: Alanine; Amides; Amino Acids; Cell Membrane Permeability; Chloroplasts; Glycine; Imines; Isoleucine; Leucine; Methionine; Osmolar Concentration; Osmotic Pressure; Phenylalanine; Plants; Proline; Serine; Sucrose; Threonine; Valine | 1970 |
Comparison of the multiple forms of bovine pancreatic deoxyribonuclease.
Topics: Acetates; Amino Acid Sequence; Amino Acids; Animals; Cattle; Cellulose; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Deoxyribonucleases; Electrophoresis; Galactose; Glucosamine; Histidine; Leucine; Mannose; Neuraminic Acids; Pancreas; Pancreatic Juice; Peptides; Proline | 1970 |
Purity and purification of 14C-lysine.
Topics: Autoanalysis; Carbon Isotopes; Chromatography, Ion Exchange; Leucine; Lysine; Methods; Phenylalanine; Proline; Threonine | 1970 |
Circular dichroism of two TMV mutants with identical single amino acid replacement in different position in polypeptide chain.
Topics: Amino Acid Sequence; Amino Acids; Chemical Phenomena; Chemistry; Circular Dichroism; Leucine; Mutation; Proline; Protein Denaturation; Temperature; Tobacco Mosaic Virus; Ultraviolet Rays; Viral Proteins | 1970 |
Intestinal dipeptidases and disaccharidases in celiac disease in adults.
Topics: Adolescent; Adult; Aged; Amino Acids; Celiac Disease; Diet Therapy; Dipeptidases; Dipeptides; Feces; Female; Folic Acid; Galactosidases; Glucosidases; Glutamates; Glutens; Glycoside Hydrolases; Humans; Intestinal Mucosa; Leucine; Lipids; Male; Middle Aged; Proline; Sucrase; Valine; Xylose | 1970 |
Isolation of enzyme-bound peptide intermediates in tyrocidine biosynthesis.
Topics: Anti-Bacterial Agents; Asparagine; Bacillus; Carbon Isotopes; Chemical Precipitation; Chromatography, Thin Layer; Esters; Leucine; Ornithine; Peptide Biosynthesis; Phenylalanine; Proline; Trichloroacetic Acid | 1970 |
The effect on the nitrogen balance of the ratio essential-non-essential amino acids in intravenously infused solutions.
Topics: Adult; Alanine; Amino Acids; Arginine; Aspartic Acid; Blood Urea Nitrogen; Female; Glycine; Histidine; Humans; Infusions, Parenteral; Isoleucine; Leucine; Lysine; Methionine; Nitrogen; Phenylalanine; Proline; Threonine; Tryptophan; Valine | 1970 |
A new hypothesis on the evolution of the genetic code.
Topics: Amino Acids; Arginine; Asparagine; Biological Evolution; Cysteine; Genetic Code; Glutamine; Leucine; Lysine; Methionine; Models, Chemical; Models, Structural; Nucleotides; Proline; Serine; Threonine; Tyrosine | 1970 |
Incorporation of 14C-leucine into brain protein in rats with hyperaminoacidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Autoanalysis; Brain; Carbon Isotopes; Female; Glycine; Histidine; Injections, Intraperitoneal; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Protein Biosynthesis; Rats; Valine | 1970 |
[Effect of amino acids on the growth of Streptococcus lactis and biosynthesis of nisin].
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Depression, Chemical; Glutamates; Glycine; Histidine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Stimulation, Chemical; Streptococcus; Threonine; Tryptophan; Valine | 1970 |
Lysine uptake in cultured Trypanosoma cruzi: interactions of competitive inhibitors.
Topics: Alanine; Animals; Biological Transport; Cysteine; Glycine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Trypanosoma; Tyrosine; Valine | 1970 |
[Hyperleucinisoleucinemia due to partial transamination defect associated with type 2 hyperprolinemia. Familial case of double aminoacidopathy].
Topics: Amino Acid Metabolism, Inborn Errors; Auditory Cortex; Child, Preschool; Deafness; Electroencephalography; Evoked Potentials; Female; Humans; Infant; Isoleucine; Leucine; Leukocytes; Male; Proline; Retinal Degeneration; Transaminases | 1970 |
[Comparative histological, electron microscopic, histochemical and biochemical studies on invasive tumor growth. V. Behavior of various proteolytic enzymes].
Topics: Aminopeptidases; Animals; Brain Chemistry; Brain Neoplasms; Carcinoma, Ehrlich Tumor; Dipeptidases; Histocytochemistry; Leucine; Mice; Microscopy, Electron; Neoplasm Transplantation; Oxytocin; Peptide Hydrolases; Proline; Trypsin | 1970 |
Unstable haemoglobin disease caused by Hb Santa Ana- 88 (F4) Leu leads to Pro.
Topics: Acetylcholinesterase; Adenosine Triphosphate; Amino Acid Sequence; Anemia, Hemolytic; Blood Group Antigens; Blood Protein Electrophoresis; Cell Membrane Permeability; Cell Survival; Chemistry Techniques, Analytical; Child; Chromium Isotopes; Electrophoresis, Disc; Electrophoresis, Paper; Erythrocytes, Abnormal; Erythropoiesis; Glucosephosphate Dehydrogenase; Glutathione; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Hungary; Immunogenetics; Iron Isotopes; Leucine; Lipids; Male; Mutation; Proline; Pyrroles | 1970 |
Nitrogen and amino acids in the feces of young pigs receiving a protein-free diet and diets containing graded levels of soybean oil meal or casein.
Topics: Alanine; Amino Acids; Animals; Caseins; Chromatography, Gas; Dietary Proteins; Feces; Glutamates; Glycine max; Isoleucine; Leucine; Male; Nitrogen; Oils; Proline; Swine | 1970 |
Patterns of neutral amino acid uptake along rat small intestine.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Betaine; Biological Transport, Active; Carbon Isotopes; Glycine; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Leucine; Male; Methionine; Proline; Rats; Stimulation, Chemical | 1971 |
Quantitative ultramicroanalysis of amino acids in the form of their DNS-derivatives. II. On the use of the dansylation reaction for quantitative estimation of amino acids.
Topics: Amino Acids; Chromatography, Thin Layer; Fluorescence; Glycine; Leucine; Mathematics; Methods; Microchemistry; Naphthalenes; Proline; Serine; Sulfonic Acids; Time Factors | 1971 |
Nutrient media for plant-parasitic nematodes. II. Amino acid requirements of Aphelenchoides sp.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Thin Layer; Culture Media; Fungi; Germ-Free Life; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Nematoda; Nutritional Requirements; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1971 |
Rapid transport of protein in the optic system of the goldfish.
Topics: Acetylcholinesterase; Animals; Asparagine; Biological Transport; Cell Nucleus; Centrifugation, Density Gradient; Chromatography, Thin Layer; Cyprinidae; DNA; Hydrolysis; Kinetics; Leucine; Microsomes; Mitochondria; Myelin Sheath; Nerve Tissue Proteins; Optic Nerve; Oxidoreductases; Proline; Ribosomes; RNA; Synaptic Vesicles; Temperature; Tritium | 1971 |
Cyanogen bromide fragments of human serum albumin.
Topics: Acetamides; Alanine; Amino Acids; Aspartic Acid; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyanides; Cysteine; Electrophoresis; Formates; Guanidines; Humans; Hydrogen-Ion Concentration; Iodoacetates; Leucine; Methods; Naphthalenes; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Quaternary Ammonium Compounds; Serum Albumin; Sulfates; Sulfhydryl Reagents; Sulfonic Acids; Tetroses; Urea | 1971 |
Isolation and properties of subunits of rat pituitary luteinizing hormone.
Topics: 1-Propanol; Acetates; Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Countercurrent Distribution; Cystine; Electrophoresis, Disc; Ethanol; Female; Fucose; Galactose; Glucosamine; Glycopeptides; Hexosamines; Immune Sera; Iodine Isotopes; Leucine; Luteinizing Hormone; Mannose; Molecular Weight; Ovary; Proline; Quaternary Ammonium Compounds; Rabbits; Radioimmunoassay; Rats; Sheep; Stimulation, Chemical; Sulfates; Tyrosine | 1971 |
Essential amino acids in the culture of Leishmania tarentolae.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Culture Media; Glucose; Glutamates; Glycine; Histidine; Leishmania; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
Serum free amino acids in piglets during the early postnatal period.
Topics: Age Factors; Amino Acids; Animals; Animals, Newborn; Female; Glycine; Leucine; Lysine; Male; Maternal-Fetal Exchange; Nitrogen; Pregnancy; Proline; Swine; Time Factors | 1971 |
Intestinal transport of amino acid residues of dipeptides. I. Influx of the glycine residue of glycyl-L-proline across mucosal border.
Topics: Animals; Carbon Isotopes; Depression, Chemical; Diffusion; Dipeptides; Glycine; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Kinetics; Leucine; Male; Methionine; Phenylalanine; Proline; Rabbits; Sodium; Tritium | 1971 |
Studies on the biosynthesis of gramicidin S in a cell-free system from Bacillus brevis. Further attempts to elucidate its mechanism of synthesis.
Topics: Amino Acids; Bacillus; Carbon Isotopes; Cell-Free System; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Leucine; Ornithine; Phenylalanine; Proline; Tyrothricin; Valine | 1967 |
[Biosphere products of Sinapis alba. I. Rhizosphere products].
Topics: Alanine; Amino Acids; Aminobutyrates; Arabinose; Arginine; Aspartic Acid; Citrates; Cysteine; Glucose; Glutamates; Glycine; Hexoses; Histidine; Keto Acids; Leucine; Mannose; Mustard Plant; Oxalates; Pentoses; Plants, Medicinal; Proline; Ribose; Threonine; Valine; Xylose | 1967 |
A transport system common to imino acids and glycine.
Topics: Amino Acids; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Glycine; Hydrogen-Ion Concentration; Hydroxyproline; In Vitro Techniques; Leucine; Mice; Proline; Temperature; Time Factors | 1967 |
[Structure analysis of hemoglobin Köln].
Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography, Gel; Chromatography, Paper; Glutamates; Hemoglobins, Abnormal; Histidine; Humans; Leucine; Methionine; Methods; Phenylalanine; Proline; Valine | 1967 |
The incorporation of acetate by the chemoautotroph Thiobacillus neapolitanus strain C.
Topics: Acetates; Arginine; Aspartic Acid; Bacterial Proteins; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Citrates; Glutamates; Leucine; Malates; Proline; Thiobacillus | 1967 |
Ammonia production by rumen microbes in vitro.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Asparagine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rumen; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Reaction of beta-propiolactone with amino acids and its specificity for methionine.
Topics: Amino Acids; Autoanalysis; Chemical Phenomena; Chemistry; Cold Temperature; Cystine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Lactones; Leucine; Lysine; Methionine; Phenylalanine; Proline; Tyrosine | 1968 |
The action of sparsomycin and gougerotin on virus growth.
Topics: Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Carbon Isotopes; Encephalitis Viruses; Glycine; Herpesviridae; Influenza A virus; Leucine; Lysine; Molecular Biology; Newcastle disease virus; Phenylalanine; Proline; RNA, Messenger; Vaccinia virus; Virus Replication; Viruses | 1968 |
Dipeptidyl arylamidase II of the pituitary. Properties of lysylalanyl-beta-naphthylamide hydrolysis: inhibition by cations, distribution in tissues, and subcellular localization.
Topics: Acid Phosphatase; Alanine; Animals; Arginine; Cattle; Centrifugation, Density Gradient; Chromatography, Paper; Cytoplasm; Dipeptides; Endopeptidases; Glycine; Hydrogen-Ion Concentration; Kidney; Kinetics; Leucine; Lithium; Lysine; Lysosomes; Methionine; Naphthalenes; Nucleosides; Pituitary Gland; Potassium; Proline; Protease Inhibitors; Puromycin; Rats; Serine; Sodium; Spleen; Thyroid Gland; Tromethamine; Tyrosine | 1968 |
Amino acid transport in kidney. Heterogeneity of alpha-aminoisobutyric uptake.
Topics: Alanine; Amides; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Choline; Cyanides; Fluorides; Glycine; Kidney; Kinetics; Leucine; Lysine; Ouabain; Proline; Rats; Sodium; Temperature | 1968 |
The molecular structures of vertebrate skin collagens. A comparative study.
Topics: Amino Acids; Animals; Anura; Arginine; Autoanalysis; Biological Evolution; Cattle; Chemical Phenomena; Chemistry, Physical; Chickens; Chromatography; Collagen; Electrophoresis; Fishes; Glutamates; Glycine; Guinea Pigs; Hydrogen-Ion Concentration; Hydroxyproline; Isoleucine; Leucine; Methionine; Optical Rotatory Dispersion; Proline; Serine; Sharks; Skin; Snakes; Solubility; Temperature; Threonine; Valine | 1968 |
Characterization of the transport of neutral amino acids by the calf lens.
Topics: Alanine; Amino Acids; Animals; Binding Sites; Biological Transport; Buffers; Carbon Isotopes; Cattle; Cell Membrane Permeability; Glycine; Lens, Crystalline; Leucine; Methionine; Phenylalanine; Proline; Protein Biosynthesis; Rabbits; Sarcosine; Tetraethylammonium Compounds; Tritium | 1968 |
Effect of sodium ions on the transport of neutral amino acids by calf lens.
Topics: Amino Acids; Animals; Binding Sites; Buffers; Carbon Isotopes; Cattle; Cell Membrane Permeability; Glycine; Lens, Crystalline; Leucine; Methionine; Potassium; Proline; Radioisotopes; Rubidium; Sarcosine; Sodium; Sodium Isotopes; Tetraethylammonium Compounds; Thiourea | 1968 |
A study of 2,4,6-trinitrobenzenesulfonic acid for automated amino acid chromatography.
Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Autoanalysis; Chromatography; Cystine; Glycine; Histidine; Hydrogen-Ion Concentration; Indicators and Reagents; Isoleucine; Leucine; Lysine; Methionine; Methods; Nitrobenzenes; Phenylalanine; Proline; Serine; Spectrophotometry; Sulfonic Acids; Temperature; Threonine; Tryptophan; Tyrosine; Urea; Valine | 1968 |
Primary structure of insoluble tendon collagen. 3. Analysis of products of tryptic digestion of native collagen.
Topics: Achilles Tendon; Alanine; Aldehydes; Amino Acids; Animals; Arginine; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Cysteine; Electrophoresis; Glutamine; Glycine; Hexosamines; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Proline; Serine; Sulfur; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Trace metal requirements for malformin biosynthesis.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Aspartic Acid; Aspergillus; Chromium; Cobalt; Copper; Cysteine; Glutamine; Glycine; Histidine; Iron; Isoleucine; Leucine; Lysine; Manganese; Metals; Molybdenum; Peptide Biosynthesis; Phenylalanine; Plant Growth Regulators; Proline; Serine; Trace Elements; Tryptophan; Tyrosine; Valine; Zinc | 1968 |
Purification of the gramicidin S synthesizing activity in Bacillus brevis extracts.
Topics: Bacillus; Carbon Isotopes; Cell-Free System; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Cold Temperature; Drug Stability; Drug Storage; Enzymes; Leucine; Ornithine; Phenylalanine; Proline; Tyrothricin; Ultrasonics; Valine; Vibration | 1968 |
Calf and pea histone IV. I. Amino acid compositions and the identical COOH-terminal 19-residue sequence.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Evolution; Bromine; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Plants; Proline; Serine; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Two procedures for accelerated separation of amino acids by column chromatography.
Topics: Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Buffers; Chromatography, Ion Exchange; Cystine; Glutamates; Glycine; Isoleucine; Leucine; Methionine; Methods; Phenylalanine; Proline; Serine; Temperature; Threonine; Tryptophan; Tyrosine; Valine | 1968 |
Gas chromatographic behavior of trimethylsilylated phenylthiohydantoin amino acids.
Topics: Alanine; Amino Acids; Arginine; Chromatography, Gas; Glutamates; Glutamine; Hydantoins; Leucine; Methionine; Methods; Methylation; Phenylalanine; Proline; Serine; Silicon; Spectrum Analysis; Tyrosine | 1968 |
Inhibition of the protein synthesis in rabbit reticulocyte by Nivalenol, a toxic principle isolated from Fusarium nivale-growing rice.
Topics: Alcaligenes; Animals; Bacillus; Biological Assay; Carbon Isotopes; Cell-Free System; Fusarium; Leucine; Lysine; Oryza; Phenylalanine; Proline; Protein Biosynthesis; Rabbits; Reticulocytes; Ribosomes; Serratia; Staphylococcus; Toxins, Biological | 1968 |
Acetylation of cycloheximide by Cunninghamella blakesleeana.
Topics: Acetates; Anhydrides; Chromatography, Thin Layer; Cycloheximide; Fungi; Leucine; Peroxides; Proline; Vitamin D | 1968 |
Inhibition of protein and DNA syntheses in Ehrlich ascites tumour by nivalenol, a toxic principle of Fusarium nivale-growing rice.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Depression, Chemical; DNA, Neoplasm; Fusarium; Leucine; Lysine; Male; Mice; Mycotoxins; Neoplasm Proteins; Oryza; Phenylalanine; Proline; Thymidine; Uracil | 1968 |
Influence of protein digestion on plasma amino acid levels in sheep.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Caseins; Digestion; Glutamates; Glycine; Histidine; Intestinal Mucosa; Isoleucine; Leucine; Lysine; Male; Phenylalanine; Proline; Sheep; Tyrosine; Valine | 1968 |
[Ribosomes of the mammary gland. Isolation and the capacity to incorporate in vitro amino acids into proteins].
Topics: Amino Acids; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Female; Lactation; Leucine; Liver; Mammary Glands, Animal; Phenylalanine; Pregnancy; Proline; Protein Biosynthesis; Rabbits; Ribosomes; Spectrum Analysis | 1968 |
Analytical techniques for cell fractions. X. High-pressure ninhydrin reaction system.
Topics: Amino Acids; Autoanalysis; Equipment and Supplies; Hot Temperature; Indicators and Reagents; Leucine; Methods; Miniaturization; Pressure; Proline; Spectrophotometry; Time Factors | 1968 |
Studies on membrane transport. 3. Further characterization of amino acid systems in Hymenolepis diminuta (Cestoda).
Topics: Absorption; Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Biological Transport; Carbon Isotopes; Cell Membrane; Cestoda; Cyclopentanes; Kinetics; Leucine; Lysine; Phenylalanine; Proline; Rats; Valine | 1968 |
In vitro studies of protein synthesis in drosophila.
Topics: Animals; Carbon Isotopes; Cattle; Cell-Free System; Drosophila; Genotype; Glutamates; Leucine; Liver; Mutation; Phenylalanine; Proline; Protein Biosynthesis; Ribosomes; RNA, Transfer; Valine | 1969 |
Hemoglobin sabine beta 91 (F 7) leu → pro. An unstable variant causing severe anemia with inclusion bodies.
Topics: Adolescent; Amino Acid Sequence; Anemia, Hemolytic; Blood Protein Electrophoresis; Chromatography; Chromium Isotopes; Erythrocyte Aging; Erythrocyte Count; Erythrocytes; Female; Fetal Hemoglobin; Globins; Heinz Bodies; Heme; Hemoglobinometry; Hemoglobins, Abnormal; Hemolysin Proteins; Histocytochemistry; Humans; Leucine; Methemoglobin; Microscopy, Fluorescence; Proline; Protein Binding; Reticulocytes; Splenectomy | 1969 |
Amino-acid receptor in larvae of Pieris brassicae (Lepidoptera).
Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Chemoreceptor Cells; Cysteine; Glutamates; Glycine; Insecta; Leucine; Methionine; Proline; Serine; Stimulation, Chemical | 1969 |
Incorporation of labeled amino acids by different segments of the proximal tubules in mice kidneys.
Topics: Animals; Kidney Tubules; Leucine; Mice; Proline; Tritium; Tyrosine | 1969 |
Effect of glucagon on concentration of several free amino acids in plasma.
Topics: Alanine; Amino Acids; Arginine; Citrulline; Cystine; Depression, Chemical; Fasting; Female; Glucagon; Glycine; Histidine; Humans; Leucine; Liver; Lysine; Male; Methionine; Nitrogen; Phenylalanine; Progesterone; Proline; Serine; Threonine; Tyrosine; Valine | 1969 |
The terminal amino acid residues of ovine interstitial cell-stimulating hormone and its subunits.
Topics: Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Chromatography, Paper; Chromatography, Thin Layer; Female; Leucine; Luteinizing Hormone; Proline; Serine; Sheep; Thiocyanates | 1969 |
Note on a selective test for the detection of sulphur amino acids.
Topics: Amino Acids; Cysteine; Cystine; Glutathione; Leucine; Methionine; Proline; Tyrosine | 1969 |
Influence of amino acid supply on ribosomes and protein synthesis of perfused rat liver.
Topics: Amino Acids; Animals; Arginine; Asparagine; In Vitro Techniques; Isoleucine; Leucine; Liver; Lysine; Male; Methionine; Perfusion; Phenylalanine; Proline; Protein Biosynthesis; Rats; Ribosomes; RNA, Messenger; Tryptophan; Valine | 1969 |
Pyrrolidonecarboxylyl peptidase: studies on the specificity of the enzyme.
Topics: Alanine; Chemical Phenomena; Chemistry; Dipeptides; Isoleucine; Leucine; Peptide Hydrolases; Phenylalanine; Proline; Pseudomonas; Pyrrolidinones; Stereoisomerism; Tyrosine; Valine | 1969 |
Fluxes of amino acids between the rat and a cestode symbiote.
Topics: Acetates; Amino Acids; Aminobutyrates; Animals; Brain; Carbon Isotopes; Cestoda; Digestive System; Fructose; Glucose; Intestinal Mucosa; Leucine; Liver; Lysine; Male; Muscles; Proline; Rats; Symbiosis | 1969 |
The effect of monovalent cations on the incorporation of various amino acids in protein synthesis by isolated rat spleen nuclei.
Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Cell Nucleus; Glycine; Leucine; Lithium; Methionine; Phenylalanine; Potassium; Proline; Protein Biosynthesis; Rats; Rubidium; Sodium; Spleen; Stimulation, Chemical; Threonine | 1969 |
Direct synthesis of p-methoxybenzyl carbazate and p-methoxybenzyloxycarbonylamino acids using p-methoxybenzyl chloroformate as reagent.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Chloroform; Glutamates; Glutamine; Glycine; Hydrazines; Indicators and Reagents; Isoleucine; Leucine; Phenylalanine; Proline; Sodium Hydroxide; Stereoisomerism; Threonine; Tyrosine; Valine | 1969 |
Statistical analysis of the distribution of amino acid residues among helical and non-helical regions in globular proteins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chymotrypsin; Hemoglobins; Leucine; Muramidase; Myoglobin; Papain; Proline; Proteins; Ribonucleases; Statistics as Topic | 1969 |
[Studies on the amino acid composition of some African legumes].
Topics: Amino Acids; Arginine; Aspartic Acid; Canavanine; Chromatography; Cystine; Food Analysis; Glutamine; Glycine; Histidine; Hot Temperature; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Plants, Edible; Proline; Proteins; Serine; Threonine; Tryptophan; Tyrosine; Valine; Vegetables | 1969 |
[Ribonucleic acids and polyribosomes of rabbit mammary gland during lactogenesis induced by prolactin].
Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; DNA; Female; Lactation; Lactose; Leucine; Mammary Glands, Animal; Pregnancy; Prolactin; Proline; Protein Biosynthesis; Rabbits; Ribosomes; RNA; Spectrophotometry; Stimulation, Chemical; Time Factors | 1969 |
Histones in early embryogenesis.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Echinodermata; Electrophoresis; Embryo, Nonmammalian; Fishes; Gels; Genetic Code; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; RNA; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
Stereochemical specificity of neutral amino acid transfer systems in rat small intestine.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Cysteine; Hydroxyproline; Ileum; Intestine, Small; Jejunum; Leucine; Methionine; Pipecolic Acids; Proline; Rats; Sarcosine; Serine; Stereoisomerism | 1969 |
[RNA isolated from turnip yellow mosaic virus; acceptor of amino acids in the presence of bacterial enzymes].
Topics: Alanine; Alcaligenes; Amino Acids; Arginine; In Vitro Techniques; Isoleucine; Leucine; Nucleotides; Phenylalanine; Plant Viruses; Proline; RNA, Viral; Serine; Ultracentrifugation; Valine | 1965 |
Incorporation of amino acids into fractions of insoluble collagen. Evaluation of metabolic homogeneity of collagen fibres.
Topics: Amino Acids; Animals; Carbon Isotopes; Chemistry Techniques, Analytical; Chick Embryo; Chromatography, Ion Exchange; Collagen; Gelatin; Glutamates; Hydroxyproline; Leucine; Proline | 1965 |
Optical resolution of D,L amino acids by gas chromatography and mass spectrometry.
Topics: Alanine; Amino Acids; Aminobutyrates; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; Glycine; Leucine; Proline; Spectrum Analysis; Thiazoles | 1965 |
Amino acid transport by the small intestine of the rat. The effect of amino acid pre-loading on the trans-intestinal amino acid transport by the everted sac preparation.
Topics: Amino Acids; Animals; Biological Transport; Glycine; In Vitro Techniques; Intestine, Small; Leucine; Lysine; Proline; Rats; Threonine | 1965 |
The mechanism of action of plant growth substances: growth substance stimulation of amino acid incorporation into nuclear protein.
Topics: Amino Acids; Carbon Isotopes; Cell Nucleus; Cocos; Dactinomycin; Gibberellins; In Vitro Techniques; Indoleacetic Acids; Leucine; Phenylalanine; Plant Growth Regulators; Plants, Edible; Proline; Puromycin; RNA | 1965 |
Amino acids in seven species of cestodes.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cestoda; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Nitrogen; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1966 |
Plasma amino acids in full-term infants.
Topics: Amino Acids; Birth Weight; Chromatography, Paper; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Leucine; Phenylalanine; Proline; Valine | 1966 |
A defined medium for growth and pigment synthesis of Micrococcus roseus.
Topics: Adenine; Amines; Arginine; Culture Media; Fructose; Glutamates; Glycine; Isoleucine; Leucine; Lutein; Methionine; Mevalonic Acid; Micrococcus; Pigments, Biological; Proline; Salts; Serine; Spectrophotometry | 1966 |
Amino acid compostion of walls from single and filamentous cells of Clostridium acidiurici.
Topics: Alanine; Amino Acids; Aspartic Acid; Bacterial Proteins; Cell Wall; Chromatography; Clostridium; Glutamates; Glycine; In Vitro Techniques; Isomerases; Leucine; Lysine; Methionine; Oxidoreductases; Phenylalanine; Proline; Serine; Valine | 1966 |
Postnatal changes in free amino acid pool of rat brain.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chromatography; Glutamates; Glutamine; Isoleucine; Leucine; Phenylalanine; Proline; Rats; Tyrosine; Valine | 1966 |
Inhibition by puromycin of amino acid transport by embryonic chick bone.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Antimetabolites; Biological Transport, Active; Bone and Bones; Chick Embryo; In Vitro Techniques; Leucine; Proline; Puromycin | 1966 |
Polyamide layer chromatography of DNP-amino acids.
Topics: Alanine; Amides; Arginine; Aspartic Acid; Chromatography; Dinitrophenols; Glutamates; Glycine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1966 |
Amino acid incorporation into protein by aseptic cell-free systems from tomato cotyledons and leaves.
Topics: Chloroplasts; Fruit; In Vitro Techniques; Leucine; Phenylalanine; Plant Proteins; Plants, Edible; Proline; Ribosomes; RNA, Viral | 1966 |
Gas chromatographic separation of DNP amino acids and its application to the analysis of serum amino acids.
Topics: Alanine; Amino Acids; Aspartic Acid; Cholesterol; Chromatography, Gas; Glutamates; Glycine; Hydroxyproline; Indicators and Reagents; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Valine | 1966 |
Nuclear histones and early embryogenesis of the chick.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Differentiation; Cell Division; Cell Nucleus; Chick Embryo; Electrophoresis; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1966 |
[The liver as a regulatory organ for the plasma concentration of free amino acids. (Studies on the isolated perfused rat liver)].
Topics: Amino Acids; Animals; Aspartic Acid; In Vitro Techniques; Isoleucine; Leucine; Liver; Perfusion; Proline; Rats; Valine | 1966 |
In vitro studies with fluoroprolines.
Topics: Animals; Body Weight; Carbon Isotopes; Female; Fluorine; Glycine; Leucine; Liver; Mice; Proline; Protein Biosynthesis | 1966 |
Free amino acids of human foetal and adult liver.
Topics: Adult; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Cystine; Female; Fetus; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Liver; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Proline; Serine; Taurine; Threonine; Tyrosine; Urea; Valine | 1966 |
Changes in the amino acid composition of proteolipids of white matter during maturation of the human nervous system.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Central Nervous System; Child; Frontal Lobe; Humans; Infant; Infant, Newborn; Leucine; Lipoproteins; Maple Syrup Urine Disease; Phenylalanine; Proline; Tyrosine | 1967 |
Free amino acids in gamma-irradiated carrots.
Topics: Acetates; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Carbon Isotopes; Glutamates; Leucine; Methionine; Plants, Edible; Proline; Radiation Effects; Serine; Threonine; Tyrosine | 1967 |
Rate constants of hydrated electron reactions with peptides and proteins.
Topics: Alanine; Albumins; Asparagine; Electrons; Gelatin; Glycine; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Weight; Muramidase; Peptides; Phenylalanine; Proline; Proteins; Ribonucleases; Tryptophan; Tyrosine; Valine | 1967 |
Further studies of amino acid transport by embryonic chick bone.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Bone and Bones; Chick Embryo; Dactinomycin; Ethylmaleimide; Glycine; In Vitro Techniques; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
On the formation of amino acids by gamma-ray-induced carboxylation of amines in aqueous solutions.
Topics: Alanine; Amines; Amino Acids; Aminobutyrates; Aspartic Acid; Carbon Dioxide; Chemistry, Organic; Cobalt Isotopes; Glutamates; Glycine; Hydrogen-Ion Concentration; Leucine; Organic Chemistry Phenomena; Proline; Radiation Effects; Valine; Water | 1967 |
Amino-acid transport by various leucocyte preparations: a comparative survey.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Cyanides; Dinitrophenols; Fluorides; Glycine; Guinea Pigs; In Vitro Techniques; Iodoacetates; Leucine; Leukocytes; Lymph Nodes; Lysine; Methionine; Proline; Serine; Spleen | 1967 |
A new developing solvent for paper chromatography of various phenolic compounds, sugars and amino acids.
Topics: Amino Acids; Anthocyanins; Arginine; Asparagine; Carbohydrates; Chromatography, Paper; Gallic Acid; Glutamates; Histidine; Indicators and Reagents; Leucine; Lysine; Methionine; Phenols; Phenylalanine; Phloroglucinol; Proline; Resorcinols; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Low-molecular-weight compounds in Macrocystis pyrifera, a marine alga.
Topics: Alanine; Alcohols; Amino Acids; Aspartic Acid; Chromatography; Eukaryota; Glutamates; Glycerol; Leucine; Proline; Succinates; Taurine; Valine | 1967 |
The recovery of amino acids from acid hydrolysates of whole urine from patients with thermal burns.
Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Burns; Creatine; Glutamates; Glycine; Histidine; Humans; Hydroxyproline; Isoleucine; Leucine; Lysine; Ornithine; Phenylalanine; Proline; Serine; Taurine; Threonine; Tyrosine; Urea; Valine | 1967 |
Plasma amino acid pattern of chicks in relation to length of feeding period.
Topics: Amino Acids; Animals; Appetite Regulation; Arginine; Birds; Cystine; Dietary Proteins; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Threonine; Tyrosine; Valine | 1967 |
Effect of fasting and of feeding a nonprotein diet on plasma amino acid levels in the chick.
Topics: Amino Acids; Animals; Arginine; Birds; Cystine; Diet; Dietary Proteins; Fasting; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Threonine; Tyrosine; Valine | 1967 |
Electron microscopic and biochemical characterization of collagen in blattarian insects.
Topics: Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Collagen; Connective Tissue Cells; Cysteine; Cystine; Female; Glutamates; Glycine; Histidine; Histocytochemistry; Hydroxyproline; Insecta; Isoleucine; Leucine; Lysine; Male; Methionine; Microscopy, Electron; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1967 |
Structural basis of kanamycin for miscoding activity.
Topics: Adenine Nucleotides; Amines; Amino Acids; Amino Sugars; Arginine; Chemical Phenomena; Chemistry; Cytosine Nucleotides; DNA; Genetic Code; Isoleucine; Kanamycin; Leucine; Lysine; Phenylalanine; Polynucleotides; Proline; Serine; Threonine; Uracil Nucleotides; Valine | 1967 |
Gluconeogenesis from amino acids in neonatal rat liver.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartate Aminotransferases; Aspartic Acid; Gluconeogenesis; Glutamates; Glycine; Histidine; In Vitro Techniques; Leucine; Liver; Liver Glycogen; Phenylalanine; Proline; Rats; Serine; Spectrophotometry; Threonine; Tyrosine; Valine | 1967 |
Haemoglobin Genova: beta-28 (B10) leucine replaced by proline.
Topics: Amino Acid Sequence; Anemia, Hemolytic, Congenital; Electrophoresis; Female; Hemoglobins; Hemoglobins, Abnormal; Humans; Italy; Leucine; Proline | 1967 |
Ergot alkaloids. I. Biosynthesis of the peptide side chain.
Topics: Alanine; Ascomycota; Carbon Isotopes; Ergot Alkaloids; Ergotamine; Leucine; Methionine; Peptide Biosynthesis; Phenylalanine; Proline; Pyruvates; Valine | 1967 |
Repression of arginase synthesis in Chang liver cells.
Topics: Animals; Arginase; Carbon Isotopes; Culture Techniques; Dactinomycin; Horses; Kinetics; Leucine; Liver; Manganese; Proline; Puromycin; RNA; RNA, Messenger; Uridine | 1967 |
The effect of progesterone on the concentration of plasma amino acids in man.
Topics: Acromegaly; Alanine; Amino Acids; Arginine; Citrulline; Cystine; Fasting; Glycine; Histidine; Humans; Isoleucine; Leucine; Liver; Lysine; Methionine; Ornithine; Phenylalanine; Progesterone; Proline; Proteins; Threonine; Tyrosine; Valine | 1967 |
Relationship between the effects of contraction and insulin on the metabolism of the isolated levator ani muscle of the rat.
Topics: Adenine; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Glucose; In Vitro Techniques; Insulin; Leucine; Male; Muscle Contraction; Muscle Proteins; Muscles; Proline; Rats; RNA; Tritium; Valine; Xylose | 1967 |
The use of in vitro models for investigating the response of fibrous joints to tensile mechanical stress.
Topics: Animals; Cell Cycle; Collagen; Cranial Sutures; Endopeptidases; Enzyme Inhibitors; Leucine; Metalloendopeptidases; Microbial Collagenase; Models, Biological; Organ Culture Techniques; Osteogenesis; Proline; Protein Biosynthesis; Rabbits; Skull; Stress, Mechanical; Tissue Inhibitor of Metalloproteinases | 1984 |
Facilitation of morphine-induced tolerance and physical dependence by prolyl-leucyl-glycinamide.
Topics: Analgesia; Animals; Body Temperature; Body Weight; Brain Chemistry; Drug Tolerance; Glycine; Humans; Leucine; Male; Mice; Morphine; Morphine Dependence; MSH Release-Inhibiting Hormone; Naloxone; Proline | 1981 |
Intestinal assimilation of a proline-containing tetrapeptide. Role of a brush border membrane postproline dipeptidyl aminopeptidase IV.
Topics: Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Female; Glycine; Hydrolysis; Intestinal Absorption; Intestinal Mucosa; Kinetics; Leucine; Microvilli; Perfusion; Proline; Rats; Rats, Inbred Strains | 1983 |
Organization of developing precruciate corticostriate projections in kittens.
Topics: Aging; Animals; Axonal Transport; Brain; Cats; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Leucine; Proline; Putamen | 1980 |
A severe hemolytic anemia related to a new case of hemoglobin Perth (Abraham Lincoln) in a French patient.
Topics: 1-Propanol; Anemia, Hemolytic; Australia; Chemical Precipitation; Child; Electrophoresis, Cellulose Acetate; Fetal Hemoglobin; France; Hemoglobin A; Hemoglobins, Abnormal; Humans; Leucine; Male; Proline | 1980 |
Autoradiographic study of ascending projections from cardiovascular sites in the nucleus tractus solitarii in the cat.
Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Cardiovascular System; Cats; Female; Hypothalamus; Leucine; Male; Proline | 1980 |
Fastigio-olivary fibers in the cat as revealed by the autoradiographic tracing method.
Topics: Animals; Autoradiography; Axonal Transport; Brain Stem; Cats; Cerebellum; Leucine; Proline; Tritium | 1980 |
Efferent connections of the cingulate gyrus in the rhesus monkey.
Topics: Animals; Axonal Transport; Brain; Efferent Pathways; Gyrus Cinguli; Leucine; Macaca mulatta; Proline | 1981 |
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum.
Topics: Acetylcholinesterase; Animals; Axonal Transport; Caudate Nucleus; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Leucine; Naloxone; Proline; Rats; Receptors, Opioid | 1981 |
Brainstem projections from the lateral hypothalamic area in the rat, as studied with autoradiography.
Topics: Animals; Autoradiography; Axonal Transport; Brain Stem; Efferent Pathways; Horseradish Peroxidase; Hypothalamus; Leucine; Proline; Rats; Tritium | 1981 |
An autoradiographic study on the terminal distribution of cerebellothalamic fibers in the cat.
Topics: Animals; Autoradiography; Axonal Transport; Cats; Cerebellum; Efferent Pathways; Leucine; Proline; Thalamus | 1981 |
Neocortical projections of the rat anterior commissure.
Topics: Animals; Autoradiography; Axonal Transport; Cerebral Cortex; Corpus Callosum; Functional Laterality; Hippocampus; Leucine; Male; Nerve Degeneration; Proline; Rats; Tritium | 1981 |
Dual topographic representation of neostriatum in the globus pallidus of rats.
Topics: Animals; Autoradiography; Axonal Transport; Axons; Corpus Striatum; Globus Pallidus; Leucine; Male; Proline; Rats; Tritium | 1982 |
Anatomical evidence for segregated focal groupings of efferent cells and their terminal ramifications in the cerebellothalamic pathway of the monkey.
Topics: Animals; Autoradiography; Axonal Transport; Cerebellum; Efferent Pathways; Leucine; Macaca fascicularis; Macaca mulatta; Proline; Thalamus; Tritium | 1983 |
Brainstem and spinal projections of the deep cerebellar nuclei in the monkey, with observations on the brainstem projections of the dorsal column nuclei.
Topics: Animals; Autoradiography; Axonal Transport; Brain Stem; Cerebellar Nuclei; Efferent Pathways; Leucine; Macaca fascicularis; Macaca mulatta; Organ Specificity; Proline; Spinal Cord; Tritium | 1983 |
Efferent projections of the visual Wulst upon the nucleus of the basal optic root in the pigeon.
Topics: Animals; Autoradiography; Axonal Transport; Columbidae; Efferent Pathways; Horseradish Peroxidase; Leucine; Nerve Degeneration; Optic Nerve; Proline; Tritium; Visual Cortex | 1983 |
The F1F0-ATPase of Escherichia coli. Substitution of proline by leucine at position 64 in the c-subunit causes loss of oxidative phosphorylation.
Topics: Adenosine Triphosphatases; Alleles; Amino Acid Sequence; Cell Membrane; Escherichia coli; Leucine; Models, Chemical; Operon; Oxidative Phosphorylation; Proline; Proton-Translocating ATPases | 1983 |
Evidence for a direct projection from the superior temporal gyrus to the entorhinal cortex in the monkey.
Topics: Afferent Pathways; Animals; Axonal Transport; Cerebral Cortex; Efferent Pathways; Hippocampus; Horseradish Peroxidase; Lectins; Leucine; Macaca fascicularis; Male; Proline; Tritium; Wheat Germ Agglutinins | 1983 |
Distribution of primary vestibular fibers in the brainstem and cerebellum of the monkey.
Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Brain Stem; Cerebellum; Leucine; Macaca fascicularis; Macaca mulatta; Proline; Saimiri; Semicircular Canals; Tritium; Vestibular Nuclei | 1984 |
In vivo biosynthesis of [35S]- and [3H]substance P in the striatum of the rat and their axonal transport to the substantia nigra.
Topics: Animals; Axonal Transport; Chromatography, High Pressure Liquid; Corpus Striatum; Leucine; Male; Methionine; Neural Pathways; Proline; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Sulfur Radioisotopes; Tritium | 1984 |
Fastigial nucleus projections to the brain stem in beagles: pathways for autonomic regulation.
Topics: Animals; Autonomic Nervous System; Axonal Transport; Blood Pressure; Brain Stem; Cerebellar Nuclei; Dogs; Efferent Pathways; Electric Stimulation; Heart Rate; Leucine; Proline | 1984 |
Intrinsic connections and architectonics of posterior parietal cortex in the rhesus monkey.
Topics: Animals; Leucine; Macaca; Macaca mulatta; Neural Pathways; Parietal Lobe; Proline; Synaptic Transmission; Tritium | 1982 |
Constructions of gene libraries of Rana nigromaculata and Mus musculus with cosmid pHC79.
Topics: Animals; Cloning, Molecular; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; DNA, Recombinant; Genetic Complementation Test; Leucine; Mathematics; Mice; Proline; Ranidae; Selection, Genetic | 1982 |
E.S.R. of spin-trapped radicals in gamma-irradiated polycrystalline amino acids. Chromatographic separation of radicals.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Deamination; Electron Spin Resonance Spectroscopy; Free Radicals; Gamma Rays; Isoleucine; Leucine; Proline; Valine | 1982 |
The thalamostriatal projection in the cat.
Topics: Animals; Autoradiography; Brain Mapping; Cats; Corpus Striatum; Horseradish Peroxidase; Lectins; Leucine; Proline; Synaptic Transmission; Thalamic Nuclei; Thalamus; Wheat Germ Agglutinins | 1984 |
Mode of action towards oligopeptides and proteins of hydrolase H, a high-molecular-weight aminoendopeptidase from rabbit skeletal muscle.
Topics: Aminopeptidases; Animals; Arginine; Chemical Phenomena; Chemistry; Endopeptidases; In Vitro Techniques; Leucine; Muscles; Oligopeptides; Proline; Protamines; Protease Inhibitors; Proteins; Rabbits; Substrate Specificity | 1983 |
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidase.
Topics: Animals; Captopril; Dipeptides; Endopeptidases; Hydrolysis; Leucine; Neprilysin; Neurotensin; Peptide Fragments; Peptide Hydrolases; Proline; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Synaptic Membranes; Thiorphan; Tiopronin; Tyrosine | 1984 |
[Luteinizing hormone of the sperm whale. Amino acid sequences of reduced and carboxymethylated beta-subunits].
Topics: Amino Acid Sequence; Amino Acids; Animals; Chromatography, Ion Exchange; Hydrolysis; Leucine; Luteinizing Hormone; Methylation; Oxidation-Reduction; Peptide Fragments; Proline; Whales | 1984 |
Evidence that cycloleucine affects the high-affinity systems of amino acid uptake in cultured human fibroblasts.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Cells, Cultured; Cycloleucine; Depression, Chemical; Fibroblasts; Humans; Kinetics; Leucine; Proline; Sodium | 1984 |
Stimulatory effect of platelet homogenate on amino acid transport into L-929 cells.
Topics: Amino Acids; Animals; Biological Transport, Active; Blood Platelets; Cattle; Cycloheximide; L Cells; Leucine; Mice; Proline | 1984 |
Regulation of amino acid transport in chicken embryo fibroblasts by purified multiplication-stimulating activity (MSA).
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cell Division; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Growth Substances; Kinetics; Leucine; Lysine; Proline; Protein Biosynthesis | 1980 |
Activation and inhibition of cerebral prolidase.
Topics: Animals; Brain; Cattle; Dipeptidases; Enzyme Activation; Leucine; Pepstatins; Peptides; Proline; Structure-Activity Relationship; Thyrotropin-Releasing Hormone | 1980 |
Relationship between the two components of the split promoter of eukaryotic tRNA genes.
Topics: Caenorhabditis; DNA, Recombinant; Eukaryotic Cells; Genes; Leucine; Mutation; Operon; Plasmids; Proline; RNA Polymerase III; RNA, Transfer; Transcription, Genetic | 1982 |
Amino acid uptake by Saccharomyces cerevisiae plasma membrane vesicles.
Topics: Amino Acids; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Membrane; Glycine; Leucine; Osmolar Concentration; Proline; Saccharomyces cerevisiae; Sodium | 1980 |
Proteolytic susceptibility of hemoglobin synthesized in the presence of amino acid analogues.
Topics: Amino Acids; Animals; Hemoglobins; Histidine; In Vitro Techniques; Leucine; Peptide Hydrolases; Phenylalanine; Proline; Rabbits; Reticulocytes; Tryptophan | 1981 |
Evidence for a single multifunctional polypeptide chain on gramicidin S synthetase 2 obtained from a wild strain and mutant strains of Bacillus brevis.
Topics: Amino Acid Isomerases; Aminoacylation; Bacillus; Binding Sites; Electrophoresis, Polyacrylamide Gel; Leucine; Molecular Weight; Multienzyme Complexes; Mutation; Ornithine; Pantothenic Acid; Peptide Synthases; Peptides; Proline; Valine | 1982 |
Extensive destruction of newly synthesized casein in mammary explants in organ culture.
Topics: Animals; Caseins; Chloroquine; Cycloheximide; Fatty Acid Synthases; Female; Hexosamines; Leucine; Mammary Glands, Animal; Organ Culture Techniques; Pregnancy; Proline; Rabbits | 1982 |
Collateral sprouting of somatosensory corticofugal axons into the cerebellar deafferented red nucleus.
Topics: Animals; Autoradiography; Axons; Cats; Cerebellum; Cerebral Cortex; Leucine; Proline; Red Nucleus; Tritium | 1982 |
Studies on inherited and acquired metabolic disorders in cultured arterial smooth muscle cells and fibroblasts.
Topics: Adolescent; Adult; Cell Division; Cells, Cultured; Child; Diabetes Mellitus; Female; Fibroblasts; Humans; Leucine; Lipoproteins; Male; Middle Aged; Muscle, Smooth, Vascular; Pancreatectomy; Proline | 1982 |
Amino acid inhibition and stimulation of 2-aminoisobutyric acid exit from anuran small intestine.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Epithelium; In Vitro Techniques; Intestine, Small; Leucine; Proline; Rana ridibunda | 1982 |
The characteristic changes of amino acid transport during development in brush border membrane vesicles of the guinea pig ileum.
Topics: Amino Acids; Animals; Biological Transport; Guinea Pigs; Ileum; Kinetics; Leucine; Membrane Fluidity; Membrane Lipids; Microvilli; Proline; Time Factors | 1982 |
Cerebello-olivary projections in the rat. An autoradiographic study.
Topics: Animals; Autoradiography; Cerebellar Nuclei; Leucine; Olivary Nucleus; Proline; Rats; Rats, Inbred Strains; Tritium | 1982 |
Circular dichroism of type 13 beta -turn in linear tripeptides containing L-proline and D-alanine.
Topics: Alanine; Circular Dichroism; Hydrogen Bonding; Leucine; Oligopeptides; Proline; Protein Conformation; Structure-Activity Relationship; Valine | 1981 |
Regulation of amino acid transport in Thiobacillus thioparus.
Topics: Amino Acids; Biological Transport, Active; Genes, Bacterial; Leucine; Mutation; Proline; Thiobacillus; Transformation, Bacterial; Tryptophan | 1981 |
Differences in glial and neuronal labeling following [3H]proline or [3H]leucine injections into the dorsal column nuclei of cats.
Topics: Animals; Autoradiography; Cats; Ganglia, Spinal; Leucine; Medulla Oblongata; Microscopy, Electron; Neuroglia; Neurons; Proline | 1981 |
The transport of neutral amino acids in cultured human fibroblasts.
Topics: Alanine; Amino Acids; Biological Transport; Cells, Cultured; Fibroblasts; Humans; Kinetics; Leucine; Osmolar Concentration; Proline; Skin | 1980 |
Cyclic peptides. VII. Synthesis and conformation of diastereomeric analogs of cyl-2 containing L-proline and L-leucine.
Topics: Amino Acid Sequence; Fungal Proteins; Leucine; Peptides, Cyclic; Proline; Protein Conformation; Stereoisomerism | 1980 |
Effect of cartilage bone marrow extract on the metabolism of collagen in osteoarthrotic cartilage.
Topics: Animals; Bone Marrow; Cartilage; Cartilage, Articular; Chick Embryo; Collagen; Glucosamine; Leucine; Osteoarthritis; Proline; Proteoglycans; Tissue Extracts | 1980 |
Unstable hemoglobin beta 32 (B 14) Leu leads to Pro, a new case discovered in Kobe.
Topics: Adolescent; Amino Acid Sequence; Amino Acids; Anemia, Hemolytic, Congenital; Hemoglobins, Abnormal; Humans; Hypertension, Pulmonary; Japan; Leucine; Male; Proline | 1980 |
A comparison of magnification functions in area 19 and the lateral suprasylvian visual area in the cat.
Topics: Animals; Axonal Transport; Brain Mapping; Cats; Horseradish Peroxidase; Leucine; Macaca; Proline; Stereotaxic Techniques; Tritium; Visual Cortex; Visual Fields; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1993 |
Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Benzoxazoles; Delavirdine; DNA Primers; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Indoles; Leucine; Molecular Sequence Data; Piperazines; Point Mutation; Proline; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 1995 |
Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.
Topics: Amino Acid Sequence; Amyloidosis; Base Sequence; DNA Primers; Electrophoresis, Polyacrylamide Gel; Genes, Lethal; Genetic Variation; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysosomes; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Prealbumin; Proline; Protein Denaturation; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship | 1995 |
Failure of intestinal amino acid absorptive mechanisms in sepsis.
Topics: Amino Acids; Aminobutyrates; Animals; Glutamic Acid; Intestinal Absorption; Leucine; Male; Proline; Rats; Rats, Sprague-Dawley; Sepsis | 1995 |
A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cell Division; Embryo, Mammalian; Embryonic and Fetal Development; Gestational Age; Humans; Immune Sera; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Leucine; Mice; Mice, Transgenic; Point Mutation; Proinsulin; Proline | 1995 |
Replacements of leucine 87 in human insulin receptor alter affinity for insulin.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Membrane; DNA Primers; DNA, Complementary; Humans; Insulin; Kinetics; Leucine; Mice; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Proline; Receptor, Insulin; Recombinant Proteins; Transfection | 1995 |
Leu110Pro substitution in the RhD polypeptide is responsible for the DVII category blood group phenotype.
Topics: Amino Acid Sequence; Base Sequence; DNA Primers; DNA, Complementary; Gene Expression; Genetic Variation; Humans; Leucine; Molecular Sequence Data; Phenotype; Point Mutation; Polymerase Chain Reaction; Proline; Protein Structure, Secondary; Reticulocytes; Rh-Hr Blood-Group System | 1995 |
Processing of the L5-67 precursor peptide and characterization of LUQIN in the LUQ neurons of Aplysia californica.
Topics: Amino Acid Sequence; Animals; Aplysia; Chromatography, High Pressure Liquid; Ganglia, Invertebrate; Leucine; Methionine; Molecular Sequence Data; Neurons; Neuropeptides; Proline; Protein Precursors; Protein Processing, Post-Translational; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tritium | 1995 |
The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Membrane; Conserved Sequence; Fluorescent Antibody Technique; Hypothyroidism; Leucine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Receptors, Thyrotropin; Structure-Activity Relationship; Thyrotropin | 1995 |
Leucine zipper-like domain regulates the autophosphorylation and the transforming activity of P130gag-fps.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Embryo, Mammalian; Fusion Proteins, gag-onc; Gene Products, gag; Immunoblotting; Leucine; Leucine Zippers; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Proline; Protein-Tyrosine Kinases; Rats; Recombinant Fusion Proteins; Retroviridae; Sequence Deletion | 1995 |
Identification and preliminary characterization of temperature-sensitive mutations affecting HlyB, the translocator required for the secretion of haemolysin (HlyA) from Escherichia coli.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Aspartic Acid; ATP-Binding Cassette Transporters; Bacterial Proteins; Base Sequence; Carrier Proteins; DNA-Binding Proteins; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Glycine; Hemolysin Proteins; Leucine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Proline; Recombinant Fusion Proteins; Repressor Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Temperature; Vancomycin; Viral Proteins; Viral Regulatory and Accessory Proteins | 1994 |
A rapid restriction site screening method for the Pro207-->Leu mutation in the lipoprotein lipase gene.
Topics: Base Sequence; DNA Mutational Analysis; DNA Primers; DNA Restriction Enzymes; France; Genetic Testing; Humans; Hyperlipoproteinemia Type I; Leucine; Lipoprotein Lipase; Molecular Epidemiology; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proline; Quebec | 1994 |
Hemolytically inactive C4B complement allotype caused by a proline to leucine mutation in the C5-binding site.
Topics: Base Sequence; Binding Sites; Complement C4b; Complement C5; DNA Primers; DNA Probes; Female; Glomerulonephritis, IGA; Haplotypes; Hemolysis; Humans; Leucine; Male; Molecular Sequence Data; Pedigree; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Proline; Protein Binding | 1994 |
Identification of the homozygous missense mutation in the lecithin:cholesterol-acyltransferase (LCAT) gene, causing LCAT familial deficiency in two French patients.
Topics: Adult; Base Sequence; Exons; Female; Homozygote; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Leucine; Male; Molecular Sequence Data; Phosphatidylcholine-Sterol O-Acyltransferase; Point Mutation; Polymerase Chain Reaction; Proline | 1994 |
Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors.
Topics: Amino Acid Sequence; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Humans; Hydrogen Bonding; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Proline; Thermodynamics | 1994 |
A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus.
Topics: Amino Acid Sequence; Arginine Vasopressin; Base Sequence; Child, Preschool; Chromosomes, Human, Pair 20; Diabetes Insipidus; Exons; Female; Humans; Leucine; Molecular Sequence Data; Mutation; Neurophysins; Pedigree; Pituitary Gland, Posterior; Polymerase Chain Reaction; Proline; Repetitive Sequences, Nucleic Acid | 1994 |
A prolyl endoproteinase that acts specifically on the extrinsic 18-kDa protein of photosystem II: purification and further characterization.
Topics: Amino Acid Sequence; Chromatography, Gel; Flavobacterium; Intracellular Membranes; Leucine; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Serine Endopeptidases; Substrate Specificity; Vegetables | 1994 |
Low-molecular-mass human salivary mucin, MG2: structure and binding of Pseudomonas aeruginosa.
Topics: Alanine; Amino Acid Sequence; Bacterial Proteins; Fimbriae, Bacterial; Glycopeptides; Humans; Isoleucine; Leucine; Molecular Sequence Data; Mucins; Oligosaccharides; Phenylalanine; Proline; Protein Binding; Pseudomonas aeruginosa; Salivary Proteins and Peptides; Trypsin; Valine | 1993 |
A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype.
Topics: Adult; Amino Acid Sequence; Base Sequence; Codon; Computer Graphics; DNA; DNA Primers; Erythrocytes; Exons; Female; Globins; Humans; Leucine; Leukocytes; Male; Models, Molecular; Molecular Sequence Data; Pedigree; Point Mutation; Polymerase Chain Reaction; Proline; Protein Structure, Secondary; Thalassemia | 1994 |
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.
Topics: Alleles; Amino Acid Sequence; Animals; Arginine; Base Sequence; Cell Line; Cells, Cultured; Child, Preschool; Chondro-4-Sulfatase; Chromosome Mapping; Consanguinity; Cysteine; DNA; DNA Primers; DNA Transposable Elements; Exons; Female; Humans; Infant; Leucine; Male; Molecular Sequence Data; Mucopolysaccharidosis VI; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Restriction Mapping; Sequence Deletion; Transfection | 1994 |
Identification of a novel mutation (Leu 256-->Pro) in the human aldolase B gene associated with hereditary fructose intolerance.
Topics: Amino Acid Sequence; Base Sequence; Child; DNA Primers; Exons; Female; Fructose Intolerance; Fructose-Bisphosphate Aldolase; Humans; Isoenzymes; Leucine; Male; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Proline; Restriction Mapping | 1994 |
Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cell Line; Gene Expression; Hyperthyroidism; Leucine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Point Mutation; Proline; Receptors, Thyrotropin; RNA, Messenger; Transfection | 1994 |
Peritonitis impairs intestinal absorption of proline and leucine in the rat.
Topics: Animals; Femoral Artery; Intestinal Absorption; Leucine; Male; Peritonitis; Portal Vein; Proline; Rats; Rats, Sprague-Dawley | 1994 |
Correlated disorder of the pure Pro22/Leu25 form of crambin at 150 K refined to 1.05-A resolution.
Topics: Amino Acid Sequence; Leucine; Models, Molecular; Molecular Sequence Data; Plant Proteins; Proline; Protein Conformation; Temperature; X-Ray Diffraction | 1994 |
In vitro effect of hormones and growth factors on the incorporation of [3H]leucine, [35S]sulfate and [3H]proline by chondrocytes of aging mice.
Topics: Aging; Animals; Autoradiography; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Glycosaminoglycans; Growth Substances; Hormones; Leucine; Male; Mice; Mice, Inbred ICR; Proline; Proteins; Sulfates; Sulfur Radioisotopes; Time Factors; Tritium | 1993 |
Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.
Topics: Amyloid; Base Sequence; DNA Primers; Humans; Hydrogen-Ion Concentration; Leucine; Molecular Sequence Data; Mutation; Prealbumin; Proline | 1993 |
The effect of retinoic acid on amino acid uptake and protein synthesis by lung fibroblasts.
Topics: Amino Acids; Aminoisobutyric Acids; Biological Transport; Cycloheximide; Fibroblasts; Humans; In Vitro Techniques; Indomethacin; Leucine; Lung; Proline; Protein Biosynthesis; Tretinoin | 1993 |
The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity.
Topics: Amino Acid Sequence; Animals; Cell Line; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Inhibitor of Differentiation Protein 1; Leucine; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Protein Binding; Protein Conformation; Repressor Proteins; Transcription Factors; Transfection | 1993 |
Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; DNA, Complementary; Gene Expression Regulation; Glomerular Mesangium; Hypertrophy; Leucine; Molecular Probes; Molecular Sequence Data; Proline; Rats; Receptors, Transforming Growth Factor beta; RNA, Messenger; Thymidine; Transforming Growth Factor beta | 1993 |
Evidence that the extracellular N-terminal domain of C5aR contains amino-acid residues crucial for C5a binding.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Complement C5a; Glycosylation; GTP-Binding Proteins; Humans; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Receptor, Anaphylatoxin C5a; Receptors, Complement; Structure-Activity Relationship; Transfection | 1993 |
Band 3 HT, a human red-cell variant associated with acanthocytosis and increased anion transport, carries the mutation Pro-868-->Leu in the membrane domain of band 3.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acanthocytes; Anion Exchange Protein 1, Erythrocyte; Anions; Biological Transport; DNA; Humans; Leucine; Mutation; Proline | 1993 |
Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy.
Topics: Acyltransferases; Alleles; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Escherichia coli; Genes, Fungal; Genotype; Kinetics; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Oligodeoxyribonucleotides; Open Reading Frames; Proline; Promoter Regions, Genetic; Recombinant Proteins; Saccharomyces cerevisiae; Temperature; Thermodynamics | 1993 |
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
Topics: Adult; Amino Acid Sequence; Base Sequence; Blotting, Western; Cells, Cultured; Cytochrome Reductases; Cytochrome-B(5) Reductase; Enzyme Stability; Fibroblasts; Humans; Kinetics; Leucine; Male; Methemoglobinemia; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligodeoxyribonucleotides; Proline; Reference Values; Skin; Thermodynamics | 1993 |
An alpha-spectrin mutation responsible for hereditary elliptocytosis associated in cis with the alpha v/41 polymorphism.
Topics: Alleles; Base Sequence; DNA Mutational Analysis; Elliptocytosis, Hereditary; Female; Gene Expression; Heterozygote; Humans; Infant; Leucine; Male; Molecular Sequence Data; Pedigree; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Spectrin | 1993 |
Cloning of genes for proline and leucine biosynthesis from Brucella abortus by functional complementation in Escherichia coli.
Topics: 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Brucella abortus; DNA Mutational Analysis; Escherichia coli; Genes, Bacterial; Genetic Complementation Test; Glutamate-5-Semialdehyde Dehydrogenase; Leucine; Proline; Restriction Mapping | 1993 |
Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B.
Topics: Cathepsin B; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Dipeptides; Kinetics; Leucine; Magnetic Resonance Spectroscopy; Papain; Proline | 1993 |
Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus.
Topics: Amino Acid Sequence; Antigens, Viral; Base Sequence; Cell Line; Gene Expression Regulation, Viral; Genome, Viral; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Leucine; Leucine Zippers; Molecular Sequence Data; Plasmids; Proline; Repetitive Sequences, Nucleic Acid; RNA, Viral; Structure-Activity Relationship; Transcriptional Activation; Transfection; Virus Replication | 1993 |
von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.
Topics: Adult; Alleles; Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; CHO Cells; Codon; Cricetinae; DNA; Exons; Female; Humans; Introns; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Transfection; von Willebrand Factor | 1993 |
Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein.
Topics: Amino Acid Sequence; Base Sequence; DNA Mutational Analysis; HIV Envelope Protein gp41; HIV-1; Isoleucine; Leucine; Leucine Zippers; Molecular Sequence Data; Proline; Protein Conformation; Protein Structure, Secondary | 1993 |
A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein.
Topics: Amino Acid Sequence; Base Sequence; Cell Cycle Proteins; Cells, Cultured; DNA; DNA-Binding Proteins; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Genetic Complementation Test; Humans; Leucine; Lymphocytes; Mitomycin; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Nuclear Proteins; Open Reading Frames; Proline; Protein Biosynthesis; Protein Conformation; Proteins; Recombinant Fusion Proteins; Transfection | 1993 |
A novel mutation (Leu817Pro) causing type 2A von Willebrand disease.
Topics: Base Sequence; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Proline; von Willebrand Diseases; von Willebrand Factor | 1996 |
Determination of amino acid isotope ratios by electrospray ionization-mass spectrometry.
Topics: Arginine; Ions; Leucine; Mass Spectrometry; Proline; Radioisotope Dilution Technique; Reproducibility of Results | 1995 |
Function and membrane topology of wild-type and mutated cytochrome P-450c21.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cytochrome P-450 Enzyme System; DNA Primers; Growth Hormone; Humans; Intracellular Membranes; Leucine; Microsomes; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Proline; Protein Biosynthesis; Rabbits; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Steroid 21-Hydroxylase; Swine; Transcription, Genetic; Transfection | 1996 |
Simple tests for rhodopsin involvement in retinitis pigmentosa.
Topics: Female; Genetic Markers; Histidine; Humans; Leucine; Male; Mutation; Pedigree; Point Mutation; Polymorphism, Restriction Fragment Length; Proline; Retinitis Pigmentosa; Rhodopsin | 1996 |
The regulation of L-proline transport by insulin-like growth factor-I in human osteoblast-like SaOS-2 cells.
Topics: Amino Acids; Amino Acids, Cyclic; beta-Alanine; Biological Transport, Active; Cell Line; Cycloheximide; Humans; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor I; Kinetics; Leucine; Osteoblasts; Proline; Protein Synthesis Inhibitors | 1996 |
Effects of amino acids on the growth of an anaerobic rumen fungus Neocallimastix sp N 13.
Topics: Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Sulfur; Animals; Fungi; Histidine; Leucine; Methionine; Proline; Rumen; Sheep; Sulfates; Sulfides | 1996 |
Ontogenetic development of proline intestinal transport in the domestic fowl.
Topics: Aging; Analysis of Variance; Animals; Biological Transport, Active; Body Weight; Chickens; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Kinetics; Leucine; Male; Mercuric Chloride; Proline | 1996 |
Evaluation of the concentration and enantiomeric purity of selected free amino acids in fermented malt beverages (beers).
Topics: Amino Acids; Beer; Chromatography, High Pressure Liquid; Fermentation; Fluorenes; Indicators and Reagents; Leucine; Phenylalanine; Proline; Reference Standards; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism | 1996 |
Destabilizing effect of proline substitutions in two helical regions of T4 lysozyme: leucine 66 to proline and leucine 91 to proline.
Topics: Circular Dichroism; Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Leucine; Muramidase; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Spectrophotometry, Ultraviolet; Urea | 1996 |
Inhibition of alanine:glyoxylate aminotransferase 1 dimerization is a prerequisite for its peroxisome-to-mitochondrion mistargeting in primary hyperoxaluria type 1.
Topics: Alanine Transaminase; Animals; Arginine; Biological Transport; COS Cells; Dimerization; Glycine; Humans; Hyperoxaluria, Primary; Leucine; Liver; Microbodies; Mitochondria; Point Mutation; Polymorphism, Genetic; Proline; Transaminases | 1996 |
Synergy in protein engineering. Mutagenic manipulation of protein structure to simplify semisynthesis.
Topics: Chemical Phenomena; Chemistry, Physical; Isoleucine; Leucine; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Engineering; Valine | 1996 |
Substitutions of Ser for Asn-163 and Pro for Leu-264 are important for stabilization of lipase from Pseudomonas aeruginosa.
Topics: Aspartic Acid; Enzyme Stability; Hydrogen-Ion Concentration; Leucine; Lipase; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Protein Conformation; Pseudomonas aeruginosa; Restriction Mapping; Serine | 1996 |
Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Calcium Channel Blockers; Cell Line; Diazoxide; Dose-Response Relationship, Drug; Glucose; Glutamine; Glyceraldehyde; Glycine; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Lysine; Potassium Channels; Proline; Radioimmunoassay; Rats; Serine; Stimulation, Chemical; Verapamil | 1996 |
Allelic variants of human calcitonin receptor in the Japanese population.
Topics: Alleles; Cell Line; DNA Primers; Genetic Variation; Humans; Japan; Leucine; Models, Structural; Polymerase Chain Reaction; Proline; Protein Conformation; Receptors, Calcitonin; Tumor Cells, Cultured | 1997 |
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.
Topics: Amino Acids; Cross-Linking Reagents; Imines; Leucine; Models, Chemical; Organophosphorus Compounds; Oxazoles; Phosphorus; Piperidines; Proline; Sulfhydryl Compounds; Thioamides | 1996 |
Mutations of cytochrome b6 in Chlamydomonas reinhardtii disclose the functional significance for a proline to leucine conversion by petB editing in maize and tobacco.
Topics: Animals; Chlamydomonas reinhardtii; Chloroplasts; Codon; Cytochrome b Group; Cytochrome b6f Complex; Darkness; Genes, Plant; Leucine; Light; Mutagenesis, Site-Directed; Nicotiana; Oligodeoxyribonucleotides; Plant Proteins; Plants, Toxic; Polymorphism, Restriction Fragment Length; Proline; RNA Editing; Zea mays | 1997 |
Autonomic denervations affect rates of protein synthesis through changes in the intracellular proline imino-pool and mRNA in the fasting rat submandibular gland.
Topics: Animals; Autonomic Nervous System; Denervation; Fasting; Leucine; Lingual Nerve; Male; Nerve Fibers; Proline; Protein Biosynthesis; Rats; Rats, Wistar; RNA, Messenger; Submandibular Gland; Sympathectomy | 1997 |
Import of branched-chain amino acids in Saccharomyces cerevisiae.
Topics: Amino Acid Transport Systems; Amino Acids; Gene Expression Regulation, Fungal; Glutamine; Isoleucine; Leucine; Membrane Transport Proteins; Proline; Quaternary Ammonium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transformation, Genetic; Valine | 1996 |
DL-leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salts.
Topics: Amino Acids; Drug Resistance, Microbial; Glucose; Leucine; Microbial Sensitivity Tests; Mutation; Proline; Quaternary Ammonium Compounds; Saccharomyces cerevisiae; Salts | 1996 |
An integrin polymorphism that defines reactivity with alloantibodies generates an anchor for MHC class II peptide binding: a model for unidirectional alloimmune responses.
Topics: Antigens, CD; Epitope Mapping; HLA-DR Antigens; HLA-DRB3 Chains; Humans; Integrin beta3; Isoantibodies; Leucine; Lymphocyte Activation; Models, Immunological; Peptide Fragments; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Proline; Protein Binding; Recombinant Proteins; Solubility; T-Lymphocytes | 1997 |
Structural characterization of the products of hydroxyl-radical damage to leucine and their detection on proteins.
Topics: Cataract; Chromatography, High Pressure Liquid; Crystallins; Humans; Hydroxyl Radical; Indicators and Reagents; Lens, Crystalline; Leucine; Lipoproteins; o-Phthalaldehyde; Oligopeptides; Oxidation-Reduction; Proline; Schiff Bases; Valine | 1997 |
RAS2/PKA pathway activity is involved in the nitrogen regulation of L-leucine uptake in Saccharomyces cerevisiae.
Topics: Amino Acid Transport Systems; Amino Acids; Biological Transport; Culture Media; Cyclic AMP-Dependent Protein Kinases; Fungal Proteins; Genes, Dominant; Kinetics; Leucine; Membrane Transport Proteins; Mutation; Nitrogen; Proline; ras Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1997 |
The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity.
Topics: Alleles; Carboxy-Lyases; Cloning, Molecular; Conserved Sequence; Epitopes; Gene Expression; Genes, Fungal; Leucine; Mevalonic Acid; Point Mutation; Proline; Saccharomyces cerevisiae; Temperature | 1997 |
Visual and chemical release of feeding behavior in adult rainbow trout.
Topics: Alanine; Amino Acids; Animals; Arginine; Betaine; Bites and Stings; Dose-Response Relationship, Drug; Feeding Behavior; Glycine; Leucine; Movement; Olfactory Pathways; Oncorhynchus mykiss; Photic Stimulation; Proline; Propionates; Reproducibility of Results; Stimulation, Chemical; Swimming; Taste; Valine | 1997 |
Intestinal absorption of proline and leucine in chronically catheterized rats.
Topics: Anesthesia; Animals; Catheterization; Intestinal Absorption; Intestinal Mucosa; Laparotomy; Leucine; Male; Proline; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Oxidative protein damage and degradation in lymphocytes from patients infected with human immunodeficiency virus.
Topics: Adult; CD3 Complex; DNA; HIV Infections; Humans; Interleukin-2; Leucine; Lymphocyte Activation; Lymphocytes; Middle Aged; Oxidative Stress; Proline; Reactive Oxygen Species; Receptors, Interleukin-2; Superoxide Dismutase; Superoxides | 1997 |
Molecular epidemiology of hepatitis B virus in Central America reflected in the genetic variability of the small S gene.
Topics: Amino Acid Sequence; Central America; DNA, Viral; Genes, Viral; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Leucine; Molecular Epidemiology; Molecular Sequence Data; Phylogeny; Point Mutation; Polymerase Chain Reaction; Proline; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Threonine | 1997 |
FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.
Topics: Amino Acid Sequence; Calcineurin; Calcium Channels; Carrier Proteins; DNA-Binding Proteins; Heat-Shock Proteins; Inositol 1,4,5-Trisphosphate Receptors; Leucine; Molecular Sequence Data; Proline; Protein Binding; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Saccharomyces cerevisiae; Tacrolimus; Tacrolimus Binding Proteins | 1997 |
A new mutation in the human lipoprotein lipase gene causing familial hyperchylomicronaemia.
Topics: Child; Exons; Female; Humans; Hyperlipoproteinemia Type I; Infant, Newborn; Leucine; Lipoprotein Lipase; Male; Point Mutation; Polymerase Chain Reaction; Proline | 1997 |
Chicken rotavirus Ch-1 shows a second type of avian VP6 gene.
Topics: Amino Acid Sequence; Animals; Antigens, Viral; Base Sequence; Capsid; Capsid Proteins; Chickens; Genes, Viral; Genetic Variation; Leucine; Molecular Sequence Data; Mutation; Phylogeny; Proline; Rotavirus; Sequence Homology, Amino Acid; Viral Structural Proteins | 1997 |
Expression cloning of a mammalian amino acid transporter or modifier by complementation of a yeast transport mutant.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Aminoisobutyric Acids; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; Cloning, Molecular; DNA, Complementary; Gene Library; Genetic Complementation Test; Kinetics; Leucine; Male; Mammals; Mice; Molecular Sequence Data; Muscle, Skeletal; Organ Specificity; Polymerase Chain Reaction; Proline; Protein Biosynthesis; Rats; Recombinant Proteins; RNA, Messenger; Saccharomyces cerevisiae; Transcription, Genetic | 1997 |
Subunit interactions of Escherichia coli F1-ATPase: mutants of the gamma subunits defective in interaction with the epsilon subunit isolated by the yeast two-hybrid system.
Topics: Amino Acid Substitution; beta-Galactosidase; Escherichia coli; Genes, Reporter; Glutamine; Kinetics; Leucine; Macromolecular Substances; Methionine; Mutagenesis, Site-Directed; Operon; Plasmids; Proline; Proton-Translocating ATPases; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sequence Deletion; Threonine; Valine | 1997 |
Relationships between H-NS, sigma S, SpvR and growth phase in the control of spvR, the regulatory gene of the Salmonella plasmid virulence operon.
Topics: Bacterial Proteins; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Regulator; Leucine; Models, Genetic; Mutagenesis; Nuclear Proteins; Nucleic Acid Conformation; Operon; Plasmids; Proline; Promoter Regions, Genetic; Salmonella typhimurium; Sigma Factor; Transcription, Genetic; Virulence | 1997 |
From ribonuclease A toward bovine seminal ribonuclease: a step by step thermodynamic analysis.
Topics: Animals; Calorimetry, Differential Scanning; Cattle; Circular Dichroism; Cysteine; Endoribonucleases; Leucine; Male; Models, Chemical; Mutagenesis, Insertional; Proline; Recombinant Proteins; Ribonuclease, Pancreatic; Semen; Thermodynamics | 1997 |
SHBG region of the anticoagulant cofactor protein S: secondary structure prediction, circular dichroism spectroscopy, and analysis of naturally occurring mutations.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Membrane; Circular Dichroism; Complement C4b; DNA Mutational Analysis; Haplorhini; Histocompatibility Antigens; Humans; Leucine; Mice; Molecular Sequence Data; Mutation; Proline; Protein S; Protein S Deficiency; Protein Structure, Secondary; Rabbits; Rats; Receptors, Steroid; Sequence Homology, Amino Acid; Sex Hormone-Binding Globulin; Solvents; Swine | 1997 |
[D-category VII depends on amino acid substitution Leu(110)Pro].
Topics: Amino Acid Substitution; Blood Donors; Genetic Carrier Screening; Humans; Isoantibodies; Leucine; Mass Screening; Point Mutation; Proline | 1997 |
Missense mutations in codon 225 of ornithine transcarbamylase (OTC) result in decreased amounts of OTC protein: a hypothesis on the molecular mechanism of the OTC deficiency.
Topics: Animals; Base Sequence; Codon; Deoxyribonuclease HpaII; Enzyme Stability; Exons; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Leucine; Liver; Mice; Molecular Sequence Data; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Polymerase Chain Reaction; Proline; Rats; Sequence Analysis, DNA | 1997 |
Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae.
Topics: Amino Acid Transport Systems; Amino Acids; Amino Acids, Cyclic; Biological Transport; Carrier Proteins; Escherichia coli Proteins; Leucine; Membrane Transport Proteins; Proline; Saccharomyces cerevisiae; Sphingosine | 1998 |
Role of hydrophobic amino acids in gurmarin, a sweetness-suppressing polypeptide.
Topics: Amino Acid Sequence; Amino Acids; Animals; Disulfides; Drug Interactions; Glutamine; Glycine; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Male; Molecular Sequence Data; Plant Proteins; Proline; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sweetening Agents; Taste; Tryptophan; Tyrosine | 1998 |
Glycoprotein IIb Leu214Pro mutation produces glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa.
Topics: Animals; Bleeding Time; Blood Platelets; CHO Cells; Cricetinae; Dual Specificity Phosphatase 2; Fibrinogen; Humans; Immunosorbent Techniques; Leucine; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Thrombasthenia; Transfection | 1998 |
Pulmonary manifestations of Gaucher disease: an increased risk for L444P homozygotes?
Topics: Adolescent; Adult; Blood Gas Monitoring, Transcutaneous; Cause of Death; Child; Child, Preschool; Echocardiography; Female; Gaucher Disease; Genotype; Homozygote; Humans; Hypertension, Pulmonary; Infant; Italy; Leucine; Lung; Lung Diseases; Lung Diseases, Interstitial; Male; Middle Aged; Oxygen; Oxygen Consumption; Pneumonia, Aspiration; Point Mutation; Proline; Prospective Studies; Respiratory Function Tests; Risk Factors; Tomography, X-Ray Computed; Vascular Diseases | 1998 |
Analysis of the CFTR gene in Turkish cystic fibrosis patients: identification of three novel mutations (3172delAC, P1013L and M1028I).
Topics: Adenine; Amino Acid Substitution; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosine; Frameshift Mutation; Humans; Isoleucine; Leucine; Methionine; Mutation; Polymorphism, Genetic; Proline; Sequence Deletion; Turkey | 1998 |
A leucine zipper-like domain is essential for dimerization and encapsidation of bluetongue virus nucleocapsid protein VP4.
Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Binding Sites; Bluetongue virus; Capsid; Capsid Proteins; Carrier Proteins; Cell Line; Dimerization; Escherichia coli Proteins; Leucine; Leucine Zippers; Maltose-Binding Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Proline; Recombinant Fusion Proteins; Spodoptera; Viral Core Proteins; Virion; Virus Assembly | 1998 |
Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.
Topics: Amino Acid Substitution; Animals; Antigens, Nuclear; Base Sequence; Catalysis; DNA Helicases; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Complementary; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Ku Autoantigen; Leucine; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins; Proline; Protein Serine-Threonine Kinases; Radiation Tolerance; Recombination, Genetic; Tumor Cells, Cultured | 1998 |
Familial hemolytic anemia due to Hb Sabine [beta 91(F7)Leu-->Pro] identified by polymerase chain reaction.
Topics: Adult; Amino Acid Substitution; Anemia, Hemolytic, Congenital; Female; Globins; Hemoglobins, Abnormal; Humans; Infant, Newborn; Leucine; Male; Point Mutation; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Hematologic; Proline | 1998 |
Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations.
Topics: Alleles; Animals; Cell Line; Codon; Embryo, Mammalian; Gene Targeting; Genetic Vectors; Gerstmann-Straussler-Scheinker Disease; Humans; Leucine; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Prions; Proline; Protein Engineering; Stem Cells | 1995 |
Interactions of proline, serine, and leucine with isolated spinach thylakoids: solute loading during freezing is not related to membrane fluidity.
Topics: Leucine; Membrane Fluidity; Membrane Proteins; Plant Proteins; Proline; Protein Binding; Serine; Spinacia oleracea | 1998 |
Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members.
Topics: Apoptosis; Arginine; Cell Division; Cysteine; DNA Probes; Humans; Leucine; Li-Fraumeni Syndrome; Mutagenesis, Site-Directed; Neoplasm Proteins; Nuclear Proteins; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome.
Topics: Arginine; Circular Dichroism; Cysteine; Germ-Line Mutation; Humans; Leucine; Li-Fraumeni Syndrome; Nuclear Magnetic Resonance, Biomolecular; Proline; Protein Structure, Secondary; Tumor Suppressor Protein p53 | 1998 |
The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid Neuropathies; Computer Simulation; Crystallography, X-Ray; Genetic Variation; Humans; Leucine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Point Mutation; Prealbumin; Proline; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins | 1998 |
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).
Topics: Adult; Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cerebellum; Dentate Gyrus; Down Syndrome; Entorhinal Cortex; Female; Hippocampus; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Point Mutation; Poland; Presenilin-1; Proline | 1998 |
Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV.
Topics: Amino Acid Substitution; Animals; Anti-HIV Agents; Cell Line; Delavirdine; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Leucine; Mice; Proline; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfides | 1998 |
Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women.
Topics: Adult; Aged; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Genotype; Humans; Japan; Leucine; Middle Aged; Osteoporosis; Polymorphism, Genetic; Postmenopause; Proline; Protein Sorting Signals; Sequence Analysis, DNA; Transforming Growth Factor beta | 1998 |
Proline, leucine, and alanine transport in placental microvillous membrane vesicles prepared from late gestational rats.
Topics: Alanine; Animals; Biological Transport; Female; Kinetics; Leucine; Microscopy, Electron; Microvilli; Placenta; Pregnancy; Pregnancy, Animal; Proline; Rats; Rats, Wistar | 1998 |
Mutation analysis of Wilson disease in Taiwan and description of six new mutations.
Topics: Alleles; Alternative Splicing; Amino Acid Substitution; Arginine; Aspartic Acid; DNA; DNA Mutational Analysis; Glutamine; Glycine; Hepatolenticular Degeneration; Humans; Leucine; Leukocytes; Mutation; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Proline; Taiwan | 1998 |
A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Humans; Leucine; Membrane Proteins; Mexico; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Presenilin-1; Proline | 1998 |
Impaired cotranslational processing as a mechanism for type I antithrombin deficiency.
Topics: Adult; Amino Acid Substitution; Animals; Antithrombins; Cell-Free System; COS Cells; DNA Mutational Analysis; Dogs; Female; Gene Expression; Glycosylation; Humans; Leucine; Microsomes; Pancreas; Point Mutation; Proline; Protein Processing, Post-Translational; Protein Sorting Signals; Transfection | 1998 |
Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.
Topics: Amyloid; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Leucine; Methionine; Molecular Weight; Prealbumin; Proline; Protein Conformation; Protein Denaturation; Ultracentrifugation; Valine | 1998 |
Adenosine inhibits collagen and total protein synthesis in vascular smooth muscle cells.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; Aorta, Abdominal; Cells, Cultured; Collagen; Cyclic AMP; Dipyridamole; Kinetics; Leucine; Male; Muscle, Smooth, Vascular; Proline; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Xanthines | 1999 |
Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis.
Topics: Adult; Amyloid Neuropathies; Ependyma; Exons; Female; Gadolinium; Genetic Variation; Humans; Iodine Radioisotopes; Kidney; Leucine; Liver; Magnetic Resonance Imaging; Meninges; Phenotype; Point Mutation; Polymorphism, Genetic; Prealbumin; Proline; Radionuclide Imaging; Sequence Analysis, DNA; Serum Amyloid P-Component; Spleen | 1999 |
Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation.
Topics: Amino Acid Substitution; Animals; Circular Dichroism; Drug Resistance; Endopeptidase K; Escherichia coli; Leucine; Mice; Mice, Inbred BALB C; Prion Diseases; Prions; Proline; Protein Structure, Secondary; Recombinant Proteins | 1999 |
Growth characteristics of Escherichia coli HB101[pGEc47] on defined medium.
Topics: Bacteriological Techniques; Culture Media; Escherichia coli; Leucine; Metals; Proline; Recombination, Genetic; Vitamins; Yeasts | 1998 |
Fiber system linking the mid-dorsolateral frontal cortex with the retrosplenial/presubicular region in the rhesus monkey.
Topics: Animals; Axonal Transport; Frontal Lobe; Gyrus Cinguli; Hippocampus; Leucine; Macaca mulatta; Nerve Fibers; Neurons; Proline; Tritium | 1999 |
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Apolipoprotein E4; Apolipoproteins E; Exons; Female; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Proline; Reference Values; Registries; Risk Factors; United States | 1999 |
A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1.
Topics: Antisense Elements (Genetics); Codon; Exons; Female; Humans; Leucine; Middle Aged; Multiple Endocrine Neoplasia Type 1; Mutation; Mutation, Missense; Neoplasm Proteins; Pedigree; Polymorphism, Restriction Fragment Length; Proline; Proto-Oncogene Proteins | 1999 |
Molecular characterisation of the defective alpha 1-antitrypsin alleles PI Mwurzburg (Pro369Ser), Mheerlen (Pro369Leu), and Q0lisbon (Thr68Ile).
Topics: Adult; Alleles; alpha 1-Antitrypsin; Animals; Child; Female; Gene Expression; Humans; Isoleucine; Leucine; Male; Mice; Pedigree; Proline; Serine; Serine Proteinase Inhibitors; Threonine | 1999 |
A comparison of 15N proline and 13C leucine for monitoring protein biosynthesis in the skin.
Topics: Animals; Carbon Isotopes; Leucine; Nitrogen Isotopes; Proline; Protein Biosynthesis; Rabbits; Radioactive Tracers; Skin; Time Factors | 1999 |
Mutation of the N-terminal proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin.
Topics: Acetyltransferases; Bacterial Proteins; Bleomycin; Drug Resistance, Microbial; Escherichia coli; Leucine; Mutagenesis, Site-Directed; Proline; Recombinant Fusion Proteins; Streptomyces | 1999 |
Two novel missense mutations causing adrenoleukodystrophy in Italian patients.
Topics: Adrenoleukodystrophy; Adult; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Child; Female; Humans; Italy; Leucine; Male; Membrane Proteins; Mutation, Missense; Pedigree; Proline; Serine | 1999 |
Genetic association studies in coronary disease: the cause of GPIIb-IIIa polymorphisms.
Topics: Coronary Disease; Humans; Leucine; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Proline | 1999 |
Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; DNA; Drugs, Chinese Herbal; Flavanones; Flavonoids; In Vitro Techniques; Leucine; Liver; Male; Nucleic Acid Synthesis Inhibitors; Peptide Biosynthesis; Plant Roots; Proline; Rats; Rats, Sprague-Dawley; Thymidine; Tritium | 1999 |
Leu518Pro mutation of the beta ig-h3 gene causes lattice corneal dystrophy type I.
Topics: Adolescent; Adult; Base Sequence; Cornea; Corneal Dystrophies, Hereditary; DNA; Exons; Extracellular Matrix Proteins; Female; Humans; Keratoplasty, Penetrating; Leucine; Male; Middle Aged; Molecular Sequence Data; Neoplasm Proteins; Pedigree; Point Mutation; Proline; Transforming Growth Factor beta | 1999 |
Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.
Topics: Animals; Binding Sites; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; DNA-Binding Proteins; Goosecoid Protein; Homeodomain Proteins; Host Cell Factor C1; Leucine; Mesoderm; Mutation; Octamer Transcription Factor-1; Peptide Fragments; Proline; Protein Binding; Receptors, Glucocorticoid; Repressor Proteins; Tissue Distribution; Transcription Factors; Zebrafish; Zebrafish Proteins | 1999 |
Activation of recombinant bovine matrix metalloproteinase-20 and its hydrolysis of two amelogenin oligopeptides.
Topics: Alanine; Ameloblasts; Amelogenin; Amino Acids; Animals; Calcium; Cattle; Chromatography, Affinity; Chromatography, Ion Exchange; Dental Enamel Proteins; Dialysis; Enzyme Activation; Escherichia coli; Gene Expression Regulation, Enzymologic; Genetic Vectors; Hydrolysis; Leucine; Mass Spectrometry; Matrix Metalloproteinase 20; Matrix Metalloproteinases; Proline; Recombinant Proteins; Tryptophan; Zinc | 1999 |
The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions.
Topics: Amyloid; Amyloid Neuropathies; Anilino Naphthalenesulfonates; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Leucine; Microscopy, Electron; Prealbumin; Proline; Protein Binding; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Surface Properties; Ultracentrifugation | 1999 |
Identification of two novel mutations in keratin 13 as the cause of white sponge naevus.
Topics: Adolescent; Amino Acid Motifs; Amino Acid Substitution; Child; Female; Hamartoma; Humans; Keratins; Leucine; Male; Methionine; Mouth Mucosa; Mucous Membrane; Pedigree; Point Mutation; Proline; Threonine; Vagina | 1999 |
Inheritance of two different alleles of the low-density lipoprotein (LDL)-receptor gene carrying the recurrent Pro664Leu mutation in a patient with homozygous familial hypercholesterolaemia.
Topics: Alleles; Base Sequence; DNA Primers; Female; Genetic Markers; Homozygote; Humans; Hyperlipoproteinemia Type II; Leucine; Male; Microsatellite Repeats; Pedigree; Point Mutation; Proline; Receptors, LDL | 1999 |
Expression and function of the gonadotropin-releasing hormone receptor are dependent on a conserved apolar amino acid in the third intracellular loop.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Conserved Sequence; COS Cells; Gonadotropin-Releasing Hormone; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Kinetics; Leucine; Mice; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Structure, Secondary; Radioligand Assay; Receptors, LHRH; Transfection; Tyrosine | 1999 |
Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D.
Topics: Amino Acid Substitution; Antibodies, Monoclonal; Cell Adhesion Molecules; Cell Line; Herpesvirus 1, Human; Humans; Leucine; Mutation; Nectins; Proline; Protein Isoforms; Protein Structure, Tertiary; Receptors, Virus; Transfection; Viral Envelope Proteins | 2000 |
[Heterozygous protein C deficiency: apropos of 2 cases with cerebral venous thrombosis in the neonatal period].
Topics: Cerebral Hemorrhage; Cerebral Veins; Follow-Up Studies; Heterozygote; Humans; Infant, Newborn; Intracranial Thrombosis; Leucine; Male; Mutation; Proline; Protein C; Protein C Deficiency; Renal Veins; Sinus Thrombosis, Intracranial; Treatment Outcome; Venous Thrombosis | 2000 |
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children.
Topics: Birth Weight; Child; Child, Preschool; Cholesterol; Fasting; Female; Humans; Leucine; Lipids; Male; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Sex Characteristics; Triglycerides | 2000 |
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
Topics: Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Female; Genotype; Humans; Leucine; Male; Neuropeptide Y; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals | 2000 |
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
Topics: Aged; Amino Acid Substitution; Arteriosclerosis; Autonomic Nervous System; Blood Pressure; Carotid Stenosis; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Genotype; Heart Rate; Humans; Leucine; Male; Neuropeptide Y; Polymorphism, Genetic; Proline; Risk Factors | 2000 |
Neuropeptide Y polymorphism and alcohol consumption in middle-aged men.
Topics: Adult; Alcohol Drinking; Amino Acid Substitution; Data Interpretation, Statistical; DNA; Finland; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline; Protein Precursors; Protein Sorting Signals | 2000 |
A novel missense mutation (P191L) in the glucose-6-phosphate translocase gene identified in a Chinese family with glycogen storage disease 1b.
Topics: Amino Acid Substitution; Antiporters; Glycogen Storage Disease Type I; Hong Kong; Humans; Leucine; Monosaccharide Transport Proteins; Mutation, Missense; Phosphotransferases; Proline | 2000 |
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Cell Line; Child, Preschool; COS Cells; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Kidney; Leucine; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Pedigree; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thrombasthenia; Transfection; Xenopus | 2000 |
Altered intestinal transport of amino acids in cirrhotic rats: the effect of insulin-like growth factor-I.
Topics: Amino Acids; Animals; Cysteine; Glutamic Acid; Insulin-Like Growth Factor I; Intestinal Absorption; Jejunum; Kinetics; Leucine; Liver Cirrhosis, Experimental; Malabsorption Syndromes; Male; Microvilli; Nutrition Disorders; Proline; Rats; Rats, Wistar | 2000 |
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
Topics: Aged; Amino Acid Substitution; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Finland; Follow-Up Studies; Glycated Hemoglobin; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Time Factors | 2000 |
Association of a Leu(10)-->Pro polymorphism of the transforming growth factor-beta1 with genetic susceptibility to osteoporosis and spinal osteoarthritis.
Topics: Animals; Bone Density; Disease Susceptibility; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Osteoarthritis; Osteoporosis; Polymorphism, Genetic; Proline; Radius; Transforming Growth Factor beta; Transforming Growth Factor beta1; Treatment Outcome | 2000 |
The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation.
Topics: Amino Acid Substitution; Amyloidosis; Benzothiazoles; Crystallization; Doxorubicin; Humans; Iodine; Leucine; Models, Molecular; Prealbumin; Proline; Protein Binding; Protein Structure, Secondary; Thiazoles; X-Ray Diffraction | 2000 |
Renal failure after clinical heart transplantation is associated with the TGF-beta 1 codon 10 gene polymorphism.
Topics: Adult; Cyclosporine; Female; Genotype; Heart Transplantation; Humans; Immunosuppressive Agents; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Renal Insufficiency; Sequence Analysis, DNA; Transforming Growth Factor beta | 2000 |
Five novel genetic variants in the promoter and coding region of the alpha B-crystallin gene (CRYAB): -652G>A, -650C>G, -249G>C, S41Y, P51L.
Topics: Amino Acid Substitution; Crystallins; Exons; Genetic Variation; Humans; Leucine; Mutation, Missense; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Serine; Tyrosine | 2000 |
Metachromatic leukodystrophy: a novel mutation (c237delC) and extension of the haplotype associated with the P426L mutation.
Topics: Adult; Amino Acid Substitution; Cerebroside-Sulfatase; Haplotypes; Humans; Leucine; Leukodystrophy, Metachromatic; Mutation, Missense; Proline; Sequence Deletion | 2000 |
Comparative sequence analysis identified mutations outside the NSP4 cytotoxic domain of tissue culture-adapted ATCC-Wa strain of human rotavirus and a novel inter-species variable domain in its C-terminus.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cattle; Cell Line; Cloning, Molecular; DNA-Directed RNA Polymerases; Genome, Viral; Humans; Isoelectric Point; Leucine; Macaca; Molecular Sequence Data; Mutation; Proline; Rotavirus; Serine; Swine; Viral Nonstructural Proteins | 2000 |
Intestinal transport of monosaccharides and amino acids during postnatal development of mink.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Body Weight; Female; Fructose; Glucose; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Lysine; Male; Methionine; Microvilli; Mink; Monosaccharides; Proline | 2000 |
Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.
Topics: 1-Carboxyglutamic Acid; Alanine; Animals; Arginine; Cations; Circular Dichroism; Conotoxins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Leucine; Lysine; Magnetic Resonance Spectroscopy; Methionine; Mice; Mollusk Venoms; Peptides; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Temperature | 2001 |
Two new mutations (H106P and L178V) in the protoporphyrinogen oxidase gene in Argentinean patients with variegate porphyria.
Topics: Amino Acid Substitution; Flavoproteins; Histidine; Humans; Leucine; Mitochondrial Proteins; Mutation, Missense; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphyrias, Hepatic; Proline; Protoporphyrinogen Oxidase; Valine | 2000 |
Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1.
Topics: DNA; Gene Frequency; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Phenotype; Polymorphism, Genetic; Proline; Stroke | 2000 |
Intestinal apical amino acid absorption during development of the pig.
Topics: Age Factors; Amino Acids; Animals; Animals, Suckling; Aspartic Acid; Female; Intestinal Absorption; Intestine, Small; Leucine; Lysine; Methionine; Organ Size; Pregnancy; Proline; Swine | 2001 |
The destabilization of human GCAP1 by a proline to leucine mutation might cause cone-rod dystrophy.
Topics: Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Cell Line; Circular Dichroism; Cloning, Molecular; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Escherichia coli; Family Health; Glutamic Acid; Guanylate Cyclase-Activating Proteins; Hot Temperature; Humans; Leucine; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myristic Acids; Phenotype; Proline; Retinitis Pigmentosa; Sequence Homology, Amino Acid; Serine; Temperature | 2001 |
Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies.
Topics: Amino Acid Substitution; Animals; Arginine; Cysteine; Genetic Variation; Glutamine; Homeodomain Proteins; Humans; Intermediate Filament Proteins; Leucine; Membrane Glycoproteins; Mutation; Nerve Tissue Proteins; Optic Atrophies, Hereditary; Peripherins; Prevalence; Proline; Retinal Degeneration; Retinal Diseases; Retinitis Pigmentosa; Rhodopsin; Trans-Activators; Tyrosine | 2001 |
All-L-Leu-Pro-Leu-Pro: a challenging cyclization.
Topics: Cell Division; Chromatography, High Pressure Liquid; Humans; Leucine; Magnetic Resonance Spectroscopy; Models, Chemical; Peptides; Proline; Spectrometry, Mass, Electrospray Ionization; Temperature; Time Factors; Tumor Cells, Cultured | 2000 |
MODY associated with two novel hepatocyte nuclear factor-1alpha loss-of-function mutations (P112L and Q466X).
Topics: Diabetes Mellitus, Type 2; DNA; DNA Mutational Analysis; DNA-Binding Proteins; Female; Glutamine; HeLa Cells; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Hepatocytes; Humans; Immunohistochemistry; Leucine; Male; Mutagenesis, Site-Directed; Nuclear Proteins; Pedigree; Proline; Transcription Factors; Transcriptional Activation | 2000 |
Different conformations of nascent polypeptides during translocation across the ER membrane.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Dogs; Endoplasmic Reticulum; Glycosylation; Intracellular Membranes; Leucine; Membrane Transport Proteins; Microsomes; Molecular Sequence Data; Peptide Mapping; Proline; Protein Conformation; Protein Transport; Ribosomes; Signal Recognition Particle; Valine | 2000 |
Integumental amino acid uptake in a carnivorous predator mollusc (Sepia officinalis, Cephalopoda).
Topics: Alanine; Amino Acids; Animals; Biological Transport; Cations; Immunohistochemistry; Leucine; Lysine; Microscopy, Electron; Microscopy, Fluorescence; Microvilli; Mollusca; Proline; Sodium; Time Factors | 2000 |
Is the P25L a "real" VHL mutation?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; DNA Mutational Analysis; Female; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Leucine; Ligases; Male; Point Mutation; Polymorphism, Genetic; Proline; Proteins; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein | 2001 |
Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation.
Topics: Adjuvants, Immunologic; Alanine; Antibodies, Monoclonal; Antigens, CD; CD24 Antigen; CD28 Antigens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Membrane; Cells, Cultured; Epitopes, T-Lymphocyte; Humans; Interleukin-2; Interphase; Leucine; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Glycoproteins; Oligopeptides; Proline; T-Lymphocyte Subsets | 2001 |
Asymmetric synthesis of alpha-branched primary amines on solid support via novel hydrazine resins.
Topics: Amines; Hydrazines; Leucine; Magnetic Resonance Spectroscopy; Models, Chemical; Peptide Biosynthesis; Proline; Resins, Plant | 2001 |
No leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y in Japanese population or Japanese with alcoholism.
Topics: Alcoholism; Amino Acid Substitution; Asian People; DNA; DNA Mutational Analysis; DNA Primers; Gene Amplification; Hospitals, Psychiatric; Humans; Japan; Leucine; Molecular Sequence Data; Neuropeptide Y; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Protein Sorting Signals; Tokyo | 2001 |
A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population.
Topics: Adult; Base Sequence; Female; Humans; Japan; Leucine; Male; Middle Aged; Molecular Sequence Data; Neuropeptide Y; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals | 2001 |
The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker.
Topics: Adult; Age Factors; Alleles; Analysis of Variance; Arginine; Calcium Channel Blockers; Chi-Square Distribution; Codon; Confidence Intervals; Cyclosporine; DNA; Female; Gene Expression Regulation; Genotype; Gingival Overgrowth; Heterozygote; Homozygote; Humans; Immunosuppressive Agents; Kidney Transplantation; Leucine; Logistic Models; Male; Odds Ratio; Polymorphism, Genetic; Proline; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation.
Topics: Alkanes; Amino Acids; Butylamines; Catalysis; Hydroxylation; Isoleucine; Leucine; Molecular Structure; Organoplatinum Compounds; Pentanoic Acids; Proline; Stereoisomerism; Valine; Water | 2001 |
Survivability of biomolecules during extraterrestrial delivery: new results on pyrolysis of amino acids and poly-amino acids.
Topics: Amino Acids; beta-Alanine; Extraterrestrial Environment; Gels; Glutamic Acid; Hot Temperature; Leucine; Meteoroids; Phenylalanine; Piperazines; Proline; Pyrrolidonecarboxylic Acid; Silica Gel; Silicon Dioxide; Valine | 2001 |
Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men.
Topics: Adult; Blood Pressure; Carotid Artery Diseases; Disease Progression; Finland; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Risk Factors | 2001 |
GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.
Topics: Adolescent; Adult; Aged; Alleles; Amino Acid Substitution; Arginine; cis-trans-Isomerases; Female; Glutamic Acid; Glutathione Transferase; Glycine; Humans; Leucine; Lysine; Male; Methionine; Middle Aged; Proline; Threonine | 2001 |
Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Leucine; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Proline | 2001 |
Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies.
Topics: Adult; Amino Acids; Animals; Biological Transport, Active; Female; Fetal Growth Retardation; Fetus; Glycine; Humans; Leucine; Phenylalanine; Placenta; Pregnancy; Proline; Sheep | 2001 |
Transport-defective mutations alter the conformation of the energy-coupling motif of an outer membrane transporter.
Topics: Amino Acid Motifs; Amino Acid Substitution; Bacterial Outer Membrane Proteins; Bacterial Proteins; Biological Transport; Electron Spin Resonance Spectroscopy; Energy Metabolism; Energy Transfer; Escherichia coli Proteins; Leucine; Membrane Proteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Proline; Protein Conformation; Receptors, Peptide; Spin Labels; Valine; Vitamin B 12 | 2001 |
Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants.
Topics: Alanine; Animals; Antioxidants; Brefeldin A; Cell Membrane; Cell Nucleus; CHO Cells; Cricetinae; Cysteine; Immunohistochemistry; Kinetics; Leucine; Masoprocol; Monensin; Mutation; Nocodazole; Palmitic Acid; Palmitic Acids; Peptides; Proline; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pulmonary Surfactants; Recombinant Proteins; Transfection | 2002 |
C-terminal anchoring of a peptide to class II MHC via the P10 residue is compatible with a peptide bulge.
Topics: Amino Acid Substitution; Amino Acids; Antigens, CD; Binding, Competitive; Glycine; HLA-DR Antigens; HLA-DRB3 Chains; Humans; Integrin beta3; Leucine; Peptide Fragments; Platelet Membrane Glycoproteins; Proline; Protein Binding; Protein Conformation; Structure-Activity Relationship | 2002 |
Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].
Topics: Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Humans; Leucine; Luciferases; Peptides; Phosphorylation; Proline; Protein Binding; Proto-Oncogene Proteins c-fos; Receptors, Neuropeptide Y; Signal Transduction; Sulfonamides; Thapsigargin; Time Factors; Transfection; Tumor Cells, Cultured | 2002 |
Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Substitution; Dementia; Genetic Predisposition to Disease; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Mutation; Paraparesis, Spastic; Presenilin-1; Proline | 2002 |
The impact of the leucine 7 to proline 7 polymorphism of the neuropeptide Y gene on postprandial lipemia and on the response of serum total and lipoprotein lipids to a reduced fat diet.
Topics: Area Under Curve; Diet, Fat-Restricted; Dietary Fats; Female; Genotype; Humans; Leucine; Lipase; Lipids; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Postprandial Period; Proline; Triglycerides | 2002 |
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia.
Topics: Aged; Amino Acid Substitution; DNA Mutational Analysis; Family Health; Fibrinogen; Genetic Variation; Humans; Leucine; Male; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Binding; Protein Subunits; Thrombasthenia | 2002 |
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
Topics: Aged; Amino Acid Substitution; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Female; Genotype; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Triglycerides | 2002 |
A novel mutation of the cathepsin C gene in Papillon-Lefèvre syndrome.
Topics: Adolescent; Aggressive Periodontitis; Amino Acid Substitution; Cathepsin C; Consanguinity; DNA Mutational Analysis; Female; Humans; Leucine; Male; Mutation, Missense; Papillon-Lefevre Disease; Pedigree; Polymerase Chain Reaction; Proline | 2002 |
Effect of multivalency on the performance of enantioselective separation media for chiral HPLC prepared by linking multiple selectors to a porous polymer support via aliphatic dendrons.
Topics: Alanine; Amino Acids; Catalysis; Chemistry, Organic; Chromatography, High Pressure Liquid; Leucine; Ligands; Molecular Structure; Polymers; Polymethacrylic Acids; Proline; Stereoisomerism; Time Factors | 2002 |
Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils.
Topics: Amyloid Neuropathies, Familial; Humans; Leucine; Microscopy, Atomic Force; Microscopy, Electron; Microscopy, Electron, Scanning; Models, Molecular; Molecular Weight; Plaque, Amyloid; Prealbumin; Proline; Protein Binding; Protein Precursors; Protein Structure, Quaternary; Time Factors | 2002 |
In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum.
Topics: Animals; Extracellular Space; Leucine; Male; Neostriatum; Neurokinin A; Neurons; Neuropeptides; Peptide Fragments; Proline; Protease Inhibitors; Protein Structure, Tertiary; Rats; Rats, Wistar; Subcellular Fractions; Substance P; Tachykinins; Tritium | 2002 |
Inhibition of hepatic stellate cell collagen synthesis by N-(methylamino)isobutyric acid.
Topics: Actins; Amino Acids; Aminoisobutyric Acids; Animals; Cells, Cultured; Collagen Type I; Gene Expression; Hepatocytes; Leucine; Liver Cirrhosis; Proline; Rats; Respiratory Distress Syndrome | 2002 |
Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.
Topics: Ankyrin Repeat; Aspartic Acid; Circular Dichroism; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Endopeptidase K; Humans; Hydrolysis; Leucine; Melanoma; Mutation; Peptide Fragments; Proline; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Structure-Activity Relationship; Valine | 2002 |
Sequential extracts of human bone show differing collagen synthetic rates.
Topics: Adult; Aged; Animals; Bone and Bones; Collagen; Gas Chromatography-Mass Spectrometry; Humans; Keto Acids; Kinetics; Leucine; Male; Proline; Swine | 2002 |
The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population.
Topics: Adult; Base Sequence; Genetics, Population; Genotype; Humans; Korea; Leucine; Neuropeptide Y; Obesity; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals | 2002 |
Familial isolated hyperCKaemia associated with a new mutation in the caveolin-3 (CAV-3) gene.
Topics: Adult; Biopsy; Caveolin 3; Caveolins; Creatine Kinase; Female; Heterozygote; Humans; Immunohistochemistry; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Mutation; Proline | 2002 |
[Genetics of blood coagulation in young stroke patients].
Topics: Adult; Age of Onset; Blood Coagulation; Blood Coagulation Factors; Blood Donors; Europe; Factor V; Female; Fibrinogen; Humans; Hungary; Leucine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Peptidyl-Dipeptidase A; Platelet Glycoprotein GPIIb-IIIa Complex; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Prothrombin; Risk Factors; Stroke; Surveys and Questionnaires | 2002 |
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.
Topics: Amino Acid Sequence; Cells, Cultured; GTP-Binding Proteins; Humans; Leucine; Molecular Sequence Data; Mutation; Phosphoproteins; Proline; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-B; Recombinant Fusion Proteins; RGS Proteins; Sequence Homology, Amino Acid | 2002 |
Recessive inheritance and variable penetrance of slow-channel congenital myasthenic syndromes.
Topics: Adolescent; Adult; Amino Acid Sequence; Case-Control Studies; DNA Mutational Analysis; Electromyography; Genetic Predisposition to Disease; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Myasthenia Gravis; Phenylalanine; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proline; Receptors, Nicotinic | 2002 |
Proteins of axonal transport: investigation of solubility characteristics and behaviour in gel filtration.
Topics: Animals; Axonal Transport; Chromatography, Gel; Chromatography, Ion Exchange; Drug Administration Routes; Electrophoresis, Polyacrylamide Gel; Geniculate Bodies; Leucine; Membrane Proteins; Molecular Weight; Proline; Rabbits; Retinal Ganglion Cells; Solubility; Subcellular Fractions; Superior Colliculi; Tritium | 1976 |
Topological analysis of peripherin/rds and abnormal glycosylation of the pathogenic Pro216-->Leu mutation.
Topics: Amino Acid Sequence; Animals; Asparagine; Glycosylation; Intermediate Filament Proteins; Leucine; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis; Nerve Tissue Proteins; Peripherins; Point Mutation; Proline; Recombinant Proteins; Retinal Degeneration | 2002 |
Effects of epidermal growth factor on placental amino acids uptake in pregnant rats.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Epidermal Growth Factor; Female; Leucine; Microvilli; Placenta; Pregnancy; Proline; Random Allocation; Rats; Rats, Wistar; Sodium; Up-Regulation | 2002 |
Probing Src homology 2 domain ligand interactions by differential line broadening.
Topics: Isoleucine; Leucine; Ligands; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylinositol 3-Kinases; Proline; Protein Subunits; Serine; src Homology Domains; Tyrosine | 2002 |
Assessment of enamelysin (MMP-20) selectivity to three peptide bonds on amelogenin sequence.
Topics: Alanine; Amelogenesis; Amelogenin; Amino Acid Sequence; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Dental Enamel; Dental Enamel Proteins; Hydrolysis; Leucine; Matrix Metalloproteinase 20; Matrix Metalloproteinases; Methionine; Peptide Mapping; Proline; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Serine; Statistics as Topic; Substrate Specificity; Swine; Time Factors; Tooth Calcification; Tryptophan | 2002 |
Heterozygous P250L mutation of fibroblast growth factor receptor 3 in a case of isolated craniosynostosis.
Topics: Amino Acid Substitution; Child, Preschool; Cranial Sutures; Craniosynostoses; Exons; Female; Fibroblast Growth Factors; Genetic Carrier Screening; Humans; Leucine; Mutation; Proline; Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Fibroblast Growth Factor | 2002 |
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor.
Topics: Adenosine Triphosphate; Alleles; Amino Acid Substitution; Animals; Calcium; Cell Line; Cytoplasm; Humans; Immunity, Innate; Leucine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mutation; Phosphatidylserines; Proline; Protein Structure, Tertiary; Receptors, Purinergic P2; Receptors, Purinergic P2X7; T-Lymphocyte Subsets | 2002 |
Follicle-stimulating hormone interacts with exoloop 3 of the receptor.
Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cyclic AMP; DNA Mutational Analysis; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Humans; Inositol Phosphates; Kinetics; Leucine; Lysine; Models, Molecular; Molecular Sequence Data; Proline; Protein Binding; Protein Structure, Tertiary; Receptors, FSH; Signal Transduction; Software | 2002 |
Interleukin 4 co-stimulates the PDGF-BB- and bFGF-mediated proliferation of mesangial cells and myofibroblasts.
Topics: Animals; Becaplermin; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Fibroblast Growth Factor 2; Fibroblasts; Fibrosis; Glomerular Mesangium; Humans; Interleukin-4; Kidney Tubules; Leucine; Platelet-Derived Growth Factor; Proline; Proto-Oncogene Proteins c-sis | 2002 |
Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro.
Topics: Amyloid; Amyloid Neuropathies, Familial; Amyloidosis; Animals; Coloring Agents; Congo Red; Genetic Vectors; Humans; Immunohistochemistry; Intestine, Small; Leucine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Immunoelectron; Mutation; Oxidative Stress; Prealbumin; Proline; RNA, Messenger; Skin | 2002 |
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis.
Topics: Amino Acids; Anions; Asparagine; Glutamic Acid; Halogens; Histidine; Hydrolases; Isoleucine; Leucine; Mathematical Computing; Models, Chemical; Mutagenesis, Site-Directed; Phenylalanine; Proline; Quantum Theory; Static Electricity; Tryptophan; Valine | 2002 |
Hb Manawatu [alpha 37(C2)Pro-->Leu]: a new mildly unstable mutation at an invariant proline residue.
Topics: Adult; Amino Acid Substitution; Female; Genetic Variation; Hemoglobins, Abnormal; Humans; Leucine; Molecular Weight; Mutation; Proline; United Kingdom | 2002 |
Conserved proline residue at position 189 in cone visual pigments as a determinant of molecular properties different from rhodopsins.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Avian Proteins; Cell Line; Chickens; Conserved Sequence; Epitopes; Eye Proteins; Genetic Vectors; Glycine; Humans; Isoleucine; Leucine; Mice; Proline; Retinal Cone Photoreceptor Cells; Retinal Pigments; Rhodopsin; Serine; Spectrophotometry; Thermodynamics; Valine | 2002 |
Plastocyanin-cytochrome f interactions: the influence of hydrophobic patch mutations studied by NMR spectroscopy.
Topics: Binding Sites; Conserved Sequence; Cyanobacteria; Cytochromes; Cytochromes f; Glycine; Histidine; Hydrophobic and Hydrophilic Interactions; Leucine; Macromolecular Substances; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Plastocyanin; Prochlorothrix; Proline; Protons; Tyrosine | 2002 |
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
Topics: Adolescent; Adult; Amino Acid Substitution; Cell Extracts; Cell Line; Child; Chromosomes, Human, X; Coenzyme A Ligases; Female; Genetic Carrier Screening; Genetic Testing; Humans; Infant; Leucine; Lymphocytes; Male; Mental Retardation, X-Linked; Middle Aged; Molecular Diagnostic Techniques; Mutation, Missense; Pedigree; Proline; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sex Chromosome Aberrations | 2003 |
Early and persistent sensory-psychiatric symptoms in an inherited prion disease with a PrP P105L mutation.
Topics: Female; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Prion Diseases; Prions; Proline | 2002 |
Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease.
Topics: Adolescent; Alleles; Amino Acid Substitution; Animals; Calcium; Calcium-Transporting ATPases; COS Cells; Darier Disease; Family Health; Humans; Leucine; Male; Pedigree; Point Mutation; Proline; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2003 |
Impairment of signal transduction in response to stimulation of the naturally occurring Pro279Leu variant of the h5-HT7(a) receptor.
Topics: Binding, Competitive; Cell Membrane; Cells, Cultured; Cyclic AMP; Humans; Kidney; Leucine; Ligands; Proline; Protein Binding; Radioligand Assay; Receptors, Serotonin; Second Messenger Systems; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction | 2003 |
Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene.
Topics: Adenine Nucleotide Translocator 1; Adult; Biopsy; Bipolar Disorder; Blotting, Western; Electron Transport Complex IV; Female; Genes, Dominant; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Leucine; Molecular Sequence Data; Muscle, Skeletal; Mutation, Missense; Myosins; Ophthalmoplegia; Pedigree; Proline | 2003 |
Novel mutant human fibronectin FIII9-10 domain pair with increased conformational stability and biological activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Adhesion; Cells, Cultured; Escherichia coli; Fibronectins; Humans; Leucine; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Proline; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Solubility | 2002 |
No association between the TGF-beta 1 Leu10Pro polymorphism and osteoporosis among white women in the United States.
Topics: Aged; Amino Acid Sequence; Bone Density; Cohort Studies; Female; Fractures, Bone; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Multivariate Analysis; Osteoporosis; Polymorphism, Genetic; Proline; Proportional Hazards Models; Risk Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; United States; White People | 2003 |
[Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Female; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Prevalence; Proline; Protein Precursors; Spain | 2003 |
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Chromosomes, Human, X; Endopeptidases; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glycine; Humans; Hypophosphatemia; Kinetics; Leucine; Molecular Sequence Data; Oligopeptides; Peptide Fragments; PHEX Phosphate Regulating Neutral Endopeptidase; Proline; Proteins; Recombinant Proteins; Substrate Specificity | 2003 |
Neuropathological features of a case with schizophrenia and prion protein gene P102L mutation before onset of Gerstmann-Sträussler-Scheinker disease.
Topics: Amyloid beta-Peptides; Astrocytes; Brain; Family Health; Female; Gerstmann-Straussler-Scheinker Disease; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Inclusion Bodies; Leucine; Microscopy, Electron; Middle Aged; Mutation; Organ Size; Pedigree; Prions; Proline; S100 Proteins; Schizophrenia; Staining and Labeling; Ubiquitin | 2003 |
Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro).
Topics: Child, Preschool; Fibrinogens, Abnormal; Fibrinopeptide A; Humans; Leucine; Male; Mutation; Proline; Thrombin; Thrombin Time | 2003 |
4'-iodo-4'-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters.
Topics: Amino Acid Substitution; Amyloid; Animals; Caspase 3; Caspases; Cell Survival; Doxorubicin; Doxycycline; Drug Evaluation, Preclinical; Enzyme Activation; Leucine; Microscopy, Electron; Mutation; Nitrophenols; Prealbumin; Proline; Rolitetracycline; Tetracyclines; Tumor Cells, Cultured | 2003 |
A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer.
Topics: Amino Acid Substitution; Breast Neoplasms; Case-Control Studies; HeLa Cells; Humans; Leucine; Neoplasm Invasiveness; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Proline; Promoter Regions, Genetic; Protein Sorting Signals; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.
Topics: Amyloid; Computer Simulation; Humans; Hydrogen Bonding; Leucine; Models, Molecular; Point Mutation; Prealbumin; Proline; Protein Conformation; Protein Folding; Recombinant Proteins; Structure-Activity Relationship | 2003 |
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF.
Topics: Animals; Arthritis, Rheumatoid; Asparagine; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocytes; Cell Membrane; Cell Separation; Cell Survival; CHO Cells; Cricetinae; Dimerization; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin G; Leucine; Lupus Erythematosus, Systemic; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Proline; Protein Binding; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Spleen; Tumor Necrosis Factor-alpha; Valine | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; Enzyme Induction; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Leucine; Loss of Heterozygosity; Neoplasm Proteins; Polymorphism, Genetic; Proline; Recombinant Fusion Proteins; Repetitive Sequences, Amino Acid; Selenium; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Blood Pressure Determination; Brachial Artery; Child; Coronary Disease; Endothelium, Vascular; Female; Genetic Predisposition to Disease; Humans; Hypercholesterolemia; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Probability; Proline; Prospective Studies; Protein Sorting Signals; Reference Values; Risk Factors; Sampling Studies; Statistics, Nonparametric; Vasodilation | 2003 |
A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases.
Topics: Adolescent; Adult; Amino Acid Substitution; Asthma; Case-Control Studies; Cells, Cultured; Child; Dermatitis, Atopic; DNA-Binding Proteins; Female; Genetic Linkage; Genetic Predisposition to Disease; Humans; Hypersensitivity; Immunoglobulin E; Interferon gamma Receptor; Interferon-gamma; Interleukin-12; Interleukin-18; Leucine; Male; Neutrophils; Pedigree; Phosphorylation; Point Mutation; Proline; Receptors, Interferon; Rhinitis, Allergic, Perennial; STAT1 Transcription Factor; Trans-Activators | 2003 |
Targeting and assembly of mitochondrial tail-anchored protein Tom5 to the TOM complex depend on a signal distinct from that of tail-anchored proteins dispersed in the membrane.
Topics: Alanine; Amino Acid Sequence; Animals; Carrier Proteins; Cell Membrane; COS Cells; DNA; Electrophoresis, Polyacrylamide Gel; Green Fluorescent Proteins; Leucine; Luminescent Proteins; Membrane Proteins; Microscopy, Fluorescence; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Molecular Sequence Data; Phenotype; Plasmids; Proline; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Subcellular Fractions; Temperature | 2003 |
Integrin beta3 Leu33Pro homozygosity and risk of cancer.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Animals; Cytosine; Denmark; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Integrin beta3; Leucine; Male; Middle Aged; Neoplasm Invasiveness; Neoplasms; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment; Risk Factors; Thymine | 2003 |
Leucine 7 to proline 7 polymorphism of the preproneuropeptide Y gene is not associated with restenosis after coronary stenting.
Topics: Coronary Restenosis; Humans; Leucine; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors; Stents | 2003 |
Amino acid composition and electrophoretic properties of hypertensin I.
Topics: Amino Acids; Angiotensin Amide; Angiotensins; Arginine; Aspartic Acid; Glycine; Histidine; Isoleucine; Leucine; Phenylalanine; Proline; Serine; Tyrosine; Valine | 1955 |
The nutrition of animal tissues cultivated in vitro. IV. Amino acid requirements of chick embryonic heart fibroblasts.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chickens; Cystine; Fibroblasts; Glycine; Histidine; Hydroxyproline; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tissue Culture Techniques; Tryptophan; Tyrosine; Valine | 1957 |
alpha-Aminoisobutyric acid, beta-hydroxyleucine, and gamma-methylproline from the hydrolysis of a natural product.
Topics: Amino Acids; Aminoisobutyric Acids; Anti-Bacterial Agents; Antibiotics, Antitubercular; Biological Products; Hydrolysis; Leucine; Proline | 1958 |
Studies on the metabolism of valine, proline, leucine and isoleucine by rumen microorganisms in vitro.
Topics: Animals; Biochemical Phenomena; Humans; In Vitro Techniques; Isoleucine; Leucine; Proline; Rumen; Stomach; Valine | 1958 |
Amino acid dependent control of DNA synthesis in bacteria and vegetative phage.
Topics: Amino Acids; Arginine; Coliphages; Cysteine; DNA; DNA, Bacterial; Escherichia coli; Histidine; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan | 1962 |
EFFECTS OF CERTAIN AMINO ACIDS ON ANTHRANILATE PRODUCTION IN NEUROSPORA CRASSA.
Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography; Fluorescence; Leucine; Metabolism; Methionine; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Phenylalanine; Proline; Tryptophan; Tyrosine | 1963 |
GAS CHROMATOGRAPHY OF THE METHYL ESTERS OF THE AMINO ACIDS AS THE FREE BASE AND BY DISSOCIATION OF THEIR ACID SALTS.
Topics: Acetates; Amino Acids; Aspartic Acid; Chlorides; Chromatography; Chromatography, Gas; Cysteine; Cystine; Esters; Hydroxyproline; Ion Exchange Resins; Leucine; Lysine; Phenylalanine; Proline; Research; Salts; Serine | 1963 |
GENE TRANSFER BY F' STRAINS OF ESCHERICHIA COLI K-12. II. INTERACTION BETWEEN F-MEROGENOTE AND CHROMOSOME DURING TRANSFER.
Topics: Chromosomes; Escherichia coli; Escherichia coli K12; Galactose; Histidine; Isoleucine; Lactose; Leucine; Maltose; Mannitol; Methionine; Proline; Research; Serine; Streptomycin; Thiamine; Threonine; Tryptophan; Valine; Xylose | 1963 |
AMINO ACID FORMATION FROM GLUCOSE IN THE ISOLATED ADRENOCORTICAL AND THYROID TISSUE OF THE RABBIT.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Alanine; Arginine; Aspartic Acid; Chromatography; Glucose; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Pharmacology; Proline; Proteins; Rabbits; Research; Thyroid Gland; Thyrotropin | 1963 |
SPECIFICITY OF PEPSIN AND ITS DEPENDENCE ON A POSSIBLE 'HYDROPHOBICBINDING SITE'.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pepsin A; Peptides; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine; Valine | 1963 |
GAS CHROMATOGRAPHY OF AMINO ACIDS. 1. ANALYSIS OF THE MIXTURE OF METHYL-NTRIFLUOROACETYL DERIVATIVES.
Topics: Alanine; Amino Acids; Aspartic Acid; Chromatography; Chromatography, Gas; Fluoroacetates; Glutamates; Glycine; Hydroxyproline; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1963 |
AMINO-ACID CONFIGURATION OF MYCOBACILLIN.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Antifungal Agents; Aspartic Acid; Chemistry Techniques, Analytical; Glutamates; Leucine; Mycobacillin; Proline; Research; Serine; Tyrosine | 1963 |
PEPITASE ACTIVITIES IN TISSUES OF TUMOR-BEARING RATS.
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Erythrocytes; Glycine; Leucine; Liver; Liver Neoplasms; Muscles; Neoplasms; Neoplasms, Experimental; Peptide Hydrolases; Peptides; Proline; Rats; Research; Sarcoma; Sarcoma, Experimental | 1963 |
BACTERIAL POLYRIBOSOMES AND THEIR PARTICIPATION IN PROTEIN SYNTHESIS IN VIVO.
Topics: Bacillus megaterium; Bacterial Proteins; Centrifugation; Leucine; Lysine; Nucleoproteins; Polyribosomes; Proline; Protein Biosynthesis; Proteins; Research; Salmonella typhimurium; Tritium | 1963 |
ORIGIN OF PROTOTROPHIC VARIANTS IN MIXTURES OF AUXOTROPHIC MUTANTS OF SERRATIA MARCESCENS.
Topics: Adenine; Isoleucine; Leucine; Massachusetts; Mutation; Proline; Research; Serine; Serratia marcescens; Streptomycin; Thiamine; Tryptophan; Ultraviolet Rays | 1963 |
THE INHIBITION OF CEREBRAL DIGLYCINASE BY ALPHA-AMINO-, ALPHA-KETO- AND ALPHA-HYDROXY ACIDS.
Topics: Alanine; Aminobutyrates; Animals; Arginine; Aspartic Acid; Brain; Cobalt; Enzyme Inhibitors; Histidine; Hydroxy Acids; Keto Acids; Leucine; Methionine; Mice; Peptide Hydrolases; Peptides; Pharmacology; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Valine | 1963 |
OXIDATION OF L-AMINO ACIDS AND INCORPORATION INTO PROTEIN IN HOMOGENATES OF BRAIN AT TWO STAGES OF DEVELOPMENT.
Topics: Alanine; Amino Acids; Arginine; Autoradiography; Brain; Carbon Isotopes; Chromatography; Glycine; Histidine; Isoleucine; Keto Acids; Leucine; Lysine; Mice; Nerve Tissue Proteins; Phenylalanine; Proline; Proteins; Pyruvates; Research; Serine; Threonine; Valine | 1963 |
[ON THE QUANTITATIVE DETERMINATION OF AMINO ACIDS USING HIGH VOLTAGE ELECTROPHORESIS].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Blood Protein Electrophoresis; Glutamates; Histidine; Leucine; Lysine; Methionine; Ornithine; Proline; Research; Serine; Threonine; Tyrosine; Valine | 1963 |
[INCORPORATION OF LABELLED AMINO ACIDS INTO ACELLULAR FRACTIONS OF RABBIT AORTIC TISSUE].
Topics: Adenosine Triphosphate; Amino Acids; Aorta; Carbon Isotopes; Glycine; Leucine; Liver; Proline; Proteins; Rabbits; Research; RNA; Spectrophotometry; Tissue Extracts | 1963 |
STUDIES IN EXPERIMENTAL LATHYRISM. III. EFFECT OF LATHYRISM ON THE IMINO ACIDS OF CHICK EMBRYOS.
Topics: Animals; Carbon Isotopes; Chick Embryo; Collagen; Cyanides; Glutamates; Hydroxyproline; Imines; Imino Acids; Lathyrism; Leucine; Nitrogen; Proline; Proteins; Radioisotopes; Research; Toxicology | 1964 |
BIOCHEMISTRY OF LUNGS IN RELATION TO SILICOSIS. II. THE EFFECT OF QUARTZ DUST ON THE PROTEIN AMINO ACIDS OF GUINEA PIG LUNG TISSUE.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Collagen; Cystine; Dust; Glutamates; Glycine; Guinea Pigs; Histidine; Hydroxyproline; Isoleucine; Leucine; Lung; Lysine; Methionine; Phenylalanine; Proline; Quartz; Research; Serine; Silicon Dioxide; Silicosis; Threonine; Toxicology; Tyrosine; Valine | 1964 |
A DETERMINATION OF THE ESSENTIAL AMINO ACID PROPORTIONS NEEDED TO ALLOW RAPID GROWTH IN CHICKS.
Topics: Amino Acids; Amino Acids, Essential; Animals; Animals, Newborn; Arginine; Caseins; Chickens; Cystine; Diet; Dietary Proteins; Glutamates; Growth; Histidine; Isoleucine; Leucine; Lysine; Methionine; Nitrogen; Phenylalanine; Poultry; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
CELL-FREE PROTEIN SYNTHESIS: THE NATURE OF THE ACTIVE COMPLEX.
Topics: Bacterial Proteins; Carbon Isotopes; Cytoplasm; Escherichia coli; Leucine; Phenylalanine; Phosphorus Isotopes; Plant Viruses; Proline; Protein Biosynthesis; Proteins; Research; Ribosomes; RNA; RNA, Bacterial; RNA, Viral; Tritium | 1964 |
EFFECT OF AMINO ACIDS ON UPTAKE OF L-HISTIDINE BY RAT BRAIN SLICES.
Topics: Amino Acids; Arginine; Brain; Chromatography; Culture Media; Cysteine; Cystine; Dipeptides; Glutamates; Histidine; Hydroxyproline; Isoleucine; Leucine; Metabolism; Phenylalanine; Pimelic Acids; Proline; Rats; Research; Taurine; Tryptophan; Valine | 1964 |
EFFECT OF SPORULATION MEDIUM ON HEAT RESISTANCE, CHEMICAL COMPOSITION, AND GERMINATION OF BACILLUS MEGATERIUM SPORES.
Topics: Alanine; Bacillus megaterium; Bacteriological Techniques; Biochemical Phenomena; Biochemistry; Culture Media; Glucose; Glutamates; Glutamic Acid; Hot Temperature; Leucine; Nitrates; Phosphates; Picolinic Acids; Potassium; Proline; Research; Spores; Spores, Bacterial | 1964 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
CENTRIFUGAL PAPER CHROMATOGRAPHY AND SOME OF ITS APPLICATIONS.
Topics: Anthelmintics; Chromatography; Chromatography, Paper; Fumarates; Histidine; Leucine; Malates; Maleates; Organophosphate Poisoning; Phosphorus; Poisons; Proline; Research; Tetracycline; Triamcinolone; Urea | 1964 |
POLYNUCLEOTIDE ANALOGUES. II. STIMULATION OF AMINO ACID INCORPORATION BY POLYNUCLEOTIDE ANALOGUES.
Topics: Amino Acids; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Glycine; Isoleucine; Leucine; Lysine; Pharmacology; Phenylalanine; Polynucleotides; Proline; Proteins; Research; Serine; Threonine; Tryptophan; Tyrosine; Uracil Nucleotides; Valine | 1964 |
DYNAMIC PHENOMENA IN MICROSPHERES FROM THERMAL PROTEINOID.
Topics: Alanine; Arginine; Aspartic Acid; Colloids; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Microspheres; Peptides; Phenylalanine; Photomicrography; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
[SEPARATION OF AMINO ACIDS BY CHROMATOGRAPHY ON THIN LAYERS OF DIETHYLAMINOETHYL CELLULOSE].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cellulose; Chromatography; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
THE TRANSFER SYSTEM FOR NEUTRAL AMINO ACIDS IN THE RAT SMALL INTESTINE.
Topics: Amino Acids, Neutral; Ammonium Compounds; Glycine; Intestine, Small; Intestines; Leucine; Methionine; Proline; Proteins; Quaternary Ammonium Compounds; Rats; Research | 1964 |
PLASMA AMINO ACID PATTERNS IN ALCOHOLISM: THE EFFECTS OF ETHANOL LOADING.
Topics: Alanine; Alcoholism; Amino Acids; Autoanalysis; Biomedical Research; Blood; Ethanol; Genetics, Medical; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Methionine; NAD; NADP; Proline; Proteins; Serine; Toxicology; Valine | 1964 |
INFLUENCE OF BETA-AMINOPROPIONITRILE ON DISSECTING ANEURYSM AND ON PLASMA AMINO ACIDS IN THE TURKEY.
Topics: Alanine; Amino Acids; Aminopropionitrile; Ammonia; Aneurysm; Animals; Aortic Dissection; Arginine; Autoanalysis; Blood; Chromatography; Collagen; Cyanides; Diet; Histidine; Isoleucine; Leucine; Lysine; Pharmacology; Poultry; Proline; Proteins; Research; Turkey; Valine | 1964 |
STUDIES ON THE HYDROLYTIC ACTION OF PRONASE ON DERIVATIZED AND NON-DERIVATIZED PROTEINS.
Topics: Alanine; Arginine; Asparagine; Cystine; Dinitrophenols; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Peptide Hydrolases; Phenylalanine; Proline; Pronase; Proteins; Research; Ribonucleases; Streptomyces; Threonine; Tyrosine; Valine | 1964 |
INACTIVATION OF SOLUBLE RIBONUCLEIC ACID BY ELECTRON IRRADIATION.
Topics: Alanine; Amino Acids; Carbon Isotopes; Electrons; Isoleucine; Leucine; Liver; Methionine; Proline; Radiation Effects; Rats; Research; RNA; Saccharomyces; Tritium; Valine | 1964 |
MYOGLOBIN FREE-RADICALS.
Topics: Alanine; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Glycine; Histidine; Hydrogen Peroxide; Leucine; Myoglobin; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
DIFFERENTIAL MUTATION PRODUCTION BY THE DECAY OF INCORPORATED TRITIUM COMPOUNDS IN E. COLI.
Topics: Arginine; DNA; DNA, Bacterial; Escherichia coli; Histidine; Leucine; Mutation; Nucleosides; Proline; RNA; RNA, Bacterial; Thymidine; Tritium; Uracil; Uridine | 1964 |
CLEAVAGE OF PEPTIDE PROLINE BONDS BY LITHIUM ALUMINUM HYDRIDE.
Topics: Aluminum Compounds; Amides; Amino Alcohols; Ammonia; Aspartic Acid; Autoanalysis; Chromatography; Countercurrent Distribution; Glutamates; Glycine; Indicators and Reagents; Leucine; Lithium Compounds; Ornithine; Peptides; Phenylalanine; Proline; Research; Tryptophan; Tyrothricin | 1964 |
STUDIES ON THE BIOLOGICAL ACTIVITY OF RIBONUCLEIC ACID ISOLATED FROM ESCHERICHIA COLI AFTER EXPOSURE TO 5-FLUOROURACIL.
Topics: Arginine; Escherichia coli; Fluorouracil; Leucine; Metabolism; Pharmacology; Proline; Proteins; Research; RNA; RNA, Bacterial; Serine; Spectrophotometry | 1964 |
GEL FILTRATION PROPERTIES OF CCD-PREPARED E. COLI B SRNA.
Topics: Alanine; Chromatography; Chromatography, Gel; Countercurrent Distribution; Escherichia coli; Leucine; Proline; Research; RNA; RNA, Bacterial | 1964 |
CLUSTERING OF FUNCTIONALLY RELATED GENES IN SALMONELLA TYPHIMURIUM.
Topics: Arginine; Cysteine; Escherichia coli; Glycine; Guanine; Histidine; Isoleucine; Leucine; Metabolism; Methionine; Molecular Biology; Mutation; Pantothenic Acid; Proline; Purines; Pyrimidines; Research; Salmonella typhimurium; Serine; Threonine; Tryptophan | 1964 |
AMINO ACIDS AS PROTECTIVE COMPOUNDS IN ULTRAVIOLET-IRRADIATED HANSENULA WINGEI.
Topics: Alanine; Amino Acids; Arginine; Cysteine; Cystine; Ethionine; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Pichia; Proline; Radiation-Protective Agents; Research; Serine; Threonine; Tryptophan; Tyrosine; Ultraviolet Rays; Valine; Yeasts | 1964 |
STUDIES ON THE MECHANISM OF METHYLCHOLANTHRENE INDUCTION OF ENZYME ACTIVITIES OF RAT LIVER. I. AMINO ACID INCORPORATION IN RAT-LIVER HOMOGENATES.
Topics: Amino Acids; Leucine; Liver; Magnesium; Methylcholanthrene; Microsomes; Mitochondria; Phenylalanine; Proline; Rats; Research; Valine | 1964 |
INHIBITION OF ADP-INDUCED PLATELET AGGREGATION BY SUBSTITUTED AMINO-ACIDS.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Alanine; Alkylation; Amino Acids; Aminocaproates; Aminocaproic Acid; Arginine; Blood Platelets; Butyrates; Glutamine; Glycine; Guanidines; Leucine; Pharmacology; Phenylalanine; Platelet Aggregation; Proline; Research; Thrombosis; Tyrosine | 1964 |
RNA CODEWORDS AND PROTEIN SYNTHESIS. THE NUCLEOTIDE SEQUENCES OF MULTIPLE CODEWORDS FOR PHENYLALANINE, SERINE, LEUCINE, AND PROLINE.
Topics: Base Sequence; Carbon Isotopes; Chromatography; Electrophoresis; Escherichia coli; Genetic Code; Leucine; Nucleotides; Phenylalanine; Proline; Protein Biosynthesis; Proteins; Research; Ribosomes; RNA; RNA, Bacterial; Serine | 1965 |
GENETIC CONTROL OF RESTRICTION AND MODIFICATION IN ESCHERICHIA COLI.
Topics: Amino Acids; Arabinose; Arginine; Chromosomes; Coliphages; Cysteine; DNA; DNA, Bacterial; Drug Resistance; Drug Resistance, Microbial; Escherichia coli; Galactose; Genetics; Hot Temperature; Lactose; Leucine; Methionine; Proline; Research; Salmonella typhi; Streptomycin; Thiamine; Threonine; Tryptophan | 1964 |
LETHAL EFFECT OF L-LEUCINE ON E. COLI, IN VIVO CORROBORATION OF CODING AMBIGUITY.
Topics: Culture Media; Escherichia coli; Genetic Code; Histidine; Isoleucine; Leucine; Molecular Biology; Mutation; Phenylalanine; Polynucleotides; Proline; Proteins; Research; Uracil Nucleotides | 1965 |
RAT LIVER ENZYME DOES NOT ACTIVATE ACETYLAMINO ACIDS.
Topics: Acetates; Adenosine Triphosphate; Alanine; Amino Acids; Arginine; Diphosphates; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Liver; Lysine; Methionine; Phenylalanine; Proline; Rats; Research; RNA; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1965 |
RESOLUTION OF AMINO ACIDS BY GAS CHROMATOGRAPHY.
Topics: Alanine; Alcohols; Amino Acids; Chromatography; Chromatography, Gas; Glutamates; Leucine; Phenylalanine; Proline; Research; Valine | 1965 |
EFFECT OF AMINO ACIDS ON GROWTH OF SPHAEROTILUS DISCOPHORUS.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Bacteriological Techniques; Caseins; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Proline; Research; Serine; Sphaerotilus; Threonine; Tryptophan; Tyrosine; Valine | 1965 |
HIGH SENSITIVITY OPTICAL RESOLUTION OF D,L AMINO ACIDS BY GAS CHROMATOGRAPHY.
Topics: Alanine; Amino Acids; Chromatography; Chromatography, Gas; Leucine; Methionine; Phenylalanine; Proline; Research; Tyrothricin; Valine | 1965 |
GAS CHROMATOGRAPHY OF VOLATILE AMINO ACID DERIVATIVES. II. LEUCINE, CYSTEINE, PROLINE, HYDROXYPROLINE, METHIONINE, PHENYLALANINE, ASPARTIC ACID AND GLUTAMIC ACID.
Topics: Arginine; Aspartic Acid; Chromatography; Chromatography, Gas; Cysteine; Glutamates; Glutamic Acid; Hydroxyproline; Leucine; Methionine; Phenylalanine; Proline; Research | 1965 |
DECREASE IN APPETITE AND BIOCHEMICAL CHANGES IN AMINO ACID IMBALANCE IN THE RAT.
Topics: Alanine; Amino Acids; Appetite; Biochemical Phenomena; Biochemistry; Diet; Dietary Proteins; Glutamates; Glutens; Isoleucine; Kwashiorkor; Leucine; Liver; Lysine; Muscles; Proline; Rats; Research; Serine; Threonine; Valine | 1965 |
NUCLEIC ACIDS AND PROTEIN SYNTHESIS OF ISOLATED CELLS FROM CHICK EMBRYONIC SPINAL GANGLIA IN CULTURE.
Topics: Amino Acids; Animals; Autoradiography; Cell Biology; Chick Embryo; DNA; Ganglia, Spinal; Leucine; Lysine; Metabolism; Neuroglia; Neurons; Nucleic Acids; Phenylalanine; Proline; Regeneration; Research; RNA; Thymidine; Tissue Culture Techniques; Tritium; Uridine | 1965 |
SOURCE OF COLLAGEN AT EPITHELIOMESENCHYMAL INTERFACES DURING INDUCTIVE INTERACTION.
Topics: Autoradiography; Collagen; Embryology; Endopeptidases; Epithelium; Glycine; Hyaluronoglucosaminidase; Leucine; Mice; Photomicrography; Proline; Research; Salivary Glands; Tissue Culture Techniques; Tritium | 1965 |
BITTER PEPTIDE ISOLATED FROM MILK CULTURES OF STREPTOCOCCUS CREMORIS.
Topics: Alanine; Amino Acids; Arginine; Butanones; Carboxypeptidases; Chemical Phenomena; Chemistry; Chemistry Techniques, Analytical; Chromatography; Culture Media; Electrophoresis; Glutamates; Glycine; Histidine; Indicators and Reagents; Isoleucine; Leucine; Lysine; Metabolism; Methionine; Milk; Peptide Hydrolases; Peptides; Phenylalanine; Proline; Research; Streptococcus; Threonine; Tyrosine; Valine | 1965 |
THE PERIODATE OXIDATION OF AMINO ACIDS WITH REFERENCE TO STUDIES ON GLYCOPROTEINS.
Topics: Amino Acids; Cysteine; Cystine; Glycoproteins; Histidine; Hydrogen-Ion Concentration; Hydroxyproline; Indoles; Isoleucine; Leucine; Methionine; Oxidation-Reduction; Periodic Acid; Phenylalanine; Proline; Pyrroles; Research; Serine; Threonine; Tryptophan; Tyrosine | 1965 |
THE BIOSYNTHESIS OF GRAMICIDIN S IN A CELL-FREE SYSTEM.
Topics: Adenosine Triphosphate; Amino Acids; Bacillus; Carbon Isotopes; Cell-Free System; Chloramphenicol; Gramicidin; Hydrogen-Ion Concentration; Leucine; Metabolism; Ornithine; Peptides; Pharmacology; Phenylalanine; Proline; Proteins; Puromycin; Pyruvate Kinase; Pyruvates; Research; Tyrothricin; Valine | 1965 |
AMINO ACID SENSITIVITY OF STRAINS DERIVED FROM ESCHERICHIA COLI K 12.
Topics: Amino Acids; Bacteriological Techniques; Escherichia coli; Feedback; Genetics; Glycine; Growth; Isoleucine; Leucine; Methionine; Pharmacology; Proline; Research; Serotonin; Threonine; Tyrosine; Valine | 1965 |
Conditions affecting Bacillus megaterium spore germination in glucose or various nitrogenous compounds.
Topics: Alanine; Bacillus; Bacillus megaterium; Culture Media; Glucose; Leucine; Nitrogen; Nitrogen Compounds; Proline; Spores, Bacterial; Valine | 1962 |
Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores.
Topics: Alanine; Arginine; Asparagine; Bacillus; Bacillus megaterium; Culture Media; Cysteine; Hot Temperature; Leucine; Nitrates; Nitrogen; Proline; Spores, Bacterial; Valine | 1962 |
Missense mutation of Pro387Leu in protein tyrosine phosphatase-1B (PTP-1B) is not associated with type 2 diabetes in a Chinese Han population.
Topics: Asian People; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Humans; Leucine; Mutation, Missense; Proline; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases | 2003 |
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
Topics: Adenoviridae; Amino Acid Motifs; Amino Acid Sequence; Analysis of Variance; Androstadienes; Animals; Apoptosis; Blotting, Western; Brain; Carrier Proteins; Cell Fractionation; Cells, Cultured; Cloning, Molecular; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homer Scaffolding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; Leucine; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proline; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Synaptophysin; Transfection; Wortmannin | 2003 |
A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis.
Topics: Apoptosis; Cell Cycle; Cell Line; Gene Expression Regulation; Humans; Leucine; Mutation, Missense; Proline; tau Proteins | 2003 |
Modulating calcitonin fibrillogenesis: an antiparallel alpha-helical dimer inhibits fibrillation of salmon calcitonin.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Calcitonin; Chromatography, Gel; Circular Dichroism; Dimerization; Dose-Response Relationship, Drug; Guanidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Folding; Protein Structure, Secondary; Salmon; Sequence Homology, Amino Acid | 2004 |
P301L Tau mutation and non-Alzheimer dementias in Italy.
Topics: Amino Acid Substitution; Basal Ganglia; Cerebral Cortex; Dementia; Humans; Italy; Leucine; Middle Aged; Mutation; Proline; tau Proteins | 2003 |
[Familial hypocalciuric hypercalcemia].
Topics: Adult; Calcium; Female; Heterozygote; Humans; Hypercalcemia; Leucine; Proline; Receptors, Calcium-Sensing; Sequence Analysis, DNA | 2003 |
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.
Topics: Animals; Brain; Caspase 3; Caspases; Cell Count; Cell Fractionation; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Detergents; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Leucine; Luminescent Proteins; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Immunoelectron; Microtubules; Models, Neurological; Nerve Degeneration; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Phosphorylation; Proline; Sarcosine; tau Proteins; Time Factors | 2003 |
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.
Topics: Amino Acid Sequence; Cell Line; Gene Expression; Genes, Dominant; Humans; Leucine; Ligands; Methionine; Models, Structural; Molecular Sequence Data; Monocytes; Mutation; Oxazoles; Pioglitazone; Proline; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transfection; Tyrosine; Valine | 2004 |
Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation.
Topics: Active Transport, Cell Nucleus; Amino Acid Motifs; Amino Acid Sequence; Apoptosis; Base Sequence; Blotting, Western; Conserved Sequence; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Gene Expression Regulation; Humans; Interferon-alpha; Interferon-beta; Interferon-gamma; Jurkat Cells; Leucine; Luciferases; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Proline; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA; Sequence Homology, Amino Acid; STAT1 Transcription Factor; STAT2 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine | 2004 |
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
Topics: Adult; Amino Acid Substitution; Blood Glucose; Body Mass Index; Cholesterol; Coronary Disease; Diabetes Mellitus, Type 1; Female; Genotype; Glycated Hemoglobin; Humans; Leucine; Male; Mutation, Missense; Neuropeptide Y; Proline; Protein Precursors; Proteinuria; Risk Factors; Triglycerides | 2004 |
Re: Integrin beta3 Leu33Pro homozygosity and risk of cancer.
Topics: Alleles; Breast Neoplasms; Case-Control Studies; Female; Homozygote; Humans; Integrin beta3; Leucine; Polymorphism, Genetic; Proline; Risk Assessment; Risk Factors | 2004 |
The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes.
Topics: Adenosine Triphosphate; Animals; Annexin A5; Cell Membrane; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Leucine; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phospholipase D; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proline; Protein Structure, Tertiary; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Thymoma; Thymus Gland; Time Factors | 2004 |
Hepatic amyloidosis resulting from deposition of the apolipoprotein A-I variant Leu75Pro.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloidosis; Apolipoprotein A-I; DNA; Female; Genetic Variation; Humans; Leucine; Liver; Liver Diseases; Mass Spectrometry; Middle Aged; Molecular Sequence Data; Mutation; Plasma; Polymorphism, Restriction Fragment Length; Proline; Sequence Homology, Amino Acid | 2003 |
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha
Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Homozygote; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Mutation; Nuclear Proteins; Proline; Serine; Transcription Factors | 2004 |
Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides.
Topics: Animals; Antifungal Agents; Antimicrobial Cationic Peptides; Aspergillus; Candida albicans; Circular Dichroism; Fusarium; Gene Deletion; Leucine; Magainins; Peptides; Proline; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trichosporon; Xenopus; Xenopus Proteins | 2004 |
Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.
Topics: Amino Acid Sequence; Antibodies; Cell Line; Cell Line, Tumor; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Molecular Sequence Data; Mutation; Procollagen-Proline Dioxygenase; Proline; Protein Binding; Protein Processing, Post-Translational; Thermodynamics; Transcription Factors; Transcription, Genetic | 2004 |
Functional analysis of two recurrent amino acid substitutions in the CYP21 gene from Italian patients with congenital adrenal hyperplasia.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Amino Acid Substitution; Animals; Child; Child, Preschool; Chlorocebus aethiops; COS Cells; Female; Humans; Infant; Infant, Newborn; Italy; Leucine; Male; Proline; Serine; Steroid 21-Hydroxylase | 2004 |
Liver biopsy discloses a new apolipoprotein A-I hereditary amyloidosis in several unrelated Italian families.
Topics: Aged; Amyloidosis; Apolipoprotein A-I; Biopsy; DNA; Female; Heterozygote; Humans; Italy; Leucine; Liver; Male; Microscopy, Immunoelectron; Middle Aged; Mutation; Pedigree; Proline | 2004 |
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Allosteric Regulation; Anthracenes; Arginine; Binding Sites; Blotting, Western; Calorimetry; Crystallography, X-Ray; Glutamic Acid; HeLa Cells; Humans; Hydrogen Bonding; Leucine; Mitogen-Activated Protein Kinase 8; Models, Molecular; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; Transfection | 2004 |
Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.
Topics: Binding, Competitive; Cell Membrane; Electrophysiology; Genetic Variation; Humans; Imidazoles; Indoles; Ion Channels; Kidney; Kinetics; Leucine; Ligands; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Proline; Protein Binding; Radioligand Assay; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
A short alpha-helical antimicrobial peptide with antibacterial selectivity.
Topics: Amino Acid Sequence; Antimicrobial Cationic Peptides; Circular Dichroism; Dose-Response Relationship, Drug; Leucine; Molecular Sequence Data; Peptides; Proline; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Tryptophan | 2004 |
The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Motifs; Animals; beta-Galactosidase; Binding, Competitive; COS Cells; Databases as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetics; Leucine; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Peptides; Plasmids; Proline; Protein Binding; Protein Structure, Tertiary; Temperature; Threonine; Transfection; Two-Hybrid System Techniques | 2004 |
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.
Topics: Aged; Alanine; Asian People; Carcinoma, Transitional Cell; Female; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Logistic Models; Male; Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Superoxide Dismutase; Urinary Bladder Neoplasms; Valine | 2004 |
Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.
Topics: Alanine; Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Cell Line; Conserved Sequence; Cysteine; Disulfides; Humans; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Proline; Protein Structure, Tertiary; Protein Subunits; Receptors, Glycine; Tryptophan | 2004 |
Biophysical and mutational analysis of the putative bZIP domain of Epstein-Barr virus EBNA 3C.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Antigens, Viral; Cell Line, Tumor; Cell Nucleus; Circular Dichroism; Dimerization; DNA-Binding Proteins; Epstein-Barr Virus Nuclear Antigens; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leucine; Leucine Zippers; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutation; Nuclear Proteins; Proline; Protein Binding; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Viral Proteins | 2004 |
The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.
Topics: Alanine; Amino Acids; Arabinose; Arginine; Aspartic Acid; Biochemistry; Carbohydrates; Colorimetry; Copper; Cysteine; Fructose; Glucose; Glutamic Acid; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Ions; Iron; Isoleucine; Leucine; Lysine; Maltose; Metals; Models, Chemical; Phenylalanine; Proline; Serine; Sodium Chloride; Temperature; Time Factors; Valine; Xylose | 2004 |
Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Glucose; Leucine; Losartan; Male; Matrix Metalloproteinases; Myocardium; Osmolar Concentration; Proline; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Vitamin E | 2005 |
Metabolic properties of Eubacterium pyruvativorans, a ruminal 'hyper-ammonia-producing' anaerobe with metabolic properties analogous to those of Clostridium kluyveri.
Topics: Adenosine Triphosphate; Alanine; Animals; Aspartic Acid; Caseins; Clostridium; Crotonates; Energy Metabolism; Eubacterium; Fatty Acids, Volatile; Fermentation; Glycine; Lactic Acid; Leucine; Peptides; Proline; Pyruvic Acid; Rumen; Serine; Threonine | 2004 |
Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors.
Topics: Bacterial Proteins; Binding, Competitive; Cloning, Molecular; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Flavin-Adenine Dinucleotide; Furans; Humans; Leucine; Macromolecular Substances; Membrane Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Models, Molecular; Mutagenesis, Site-Directed; Peptide Fragments; Proline; Proline Oxidase; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary | 2004 |
A case of complicated spastic paraplegia 2 due to a point mutation in the proteolipid protein 1 gene.
Topics: Brain; DNA Mutational Analysis; Humans; Infant; Leucine; Magnetic Resonance Imaging; Male; Membrane Proteins; Myelin Proteolipid Protein; Paraplegia; Pelizaeus-Merzbacher Disease; Phenotype; Point Mutation; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease.
Topics: Adult; Apolipoprotein A-I; Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Heterozygote; Humans; Hyperplasia; Leucine; Male; Middle Aged; Mutation; Proline; Risk Assessment; Risk Factors | 2004 |
Asymptomatic hereditary Alexander's disease caused by a novel mutation in GFAP.
Topics: Alexander Disease; Brain; Child; DNA Mutational Analysis; Exons; Female; Glial Fibrillary Acidic Protein; Humans; Infant; Leucine; Magnetic Resonance Imaging; Male; Mutation; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Actin mutations are one cause of congenital fibre type disproportion.
Topics: Actins; Adenosine Triphosphatases; Aspartic Acid; Biopsy; Child, Preschool; DNA Mutational Analysis; Female; Heterozygote; Humans; Infant; Infant, Newborn; Leucine; Male; Models, Molecular; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Mutation, Missense; Myopathies, Structural, Congenital; Proline; Sequence Analysis, Protein; Serine; Valine | 2004 |
The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acids; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Carbon Monoxide; Cytochrome P450 Family 2; Debrisoquin; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Ethanolamines; Glycine; Kinetics; Leucine; Liver; Microsomes; Microsomes, Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Proline; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Spectrophotometry; Valine | 2004 |
Phenotypic features and genetic findings in 2 chinese families with Miyoshi distal myopathy.
Topics: Adolescent; Adult; Asian People; Distal Myopathies; DNA Mutational Analysis; Dysferlin; Exons; Family Health; Female; Genetic Linkage; Genotype; Glycine; Humans; Immunohistochemistry; Leucine; Magnetic Resonance Imaging; Male; Membrane Proteins; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Mutation; Pedigree; Phenotype; Polymorphism, Single-Stranded Conformational; Proline; Valine | 2004 |
Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the p
Topics: Alanine; Amino Acid Motifs; Animals; Azetidinecarboxylic Acid; Baculoviridae; Cell Line; Chromatography, Liquid; Culture Media, Serum-Free; Glutamic Acid; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Insecta; Ketoglutaric Acids; Kinetics; Leucine; Mass Spectrometry; Methionine; Models, Chemical; Peptides; Procollagen-Proline Dioxygenase; Proline; Protein Structure, Tertiary; Substrate Specificity; Time Factors; Transcription Factors | 2004 |
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.
Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Amino Acid Sequence; Binding Sites; Coumarins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Granzymes; Humans; Hydrolysis; Leucine; Molecular Sequence Data; Norleucine; Peptide Library; Proline; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Serpins; Structure-Activity Relationship; Substrate Specificity | 2004 |
Renal apolipoprotein A-I amyloidosis associated with a novel mutant Leu64Pro.
Topics: Amino Acid Substitution; Amyloidosis, Familial; Apolipoprotein A-I; Humans; Kidney; Kidney Diseases; Leucine; Male; Middle Aged; Mutation; Proline | 2004 |
Severe hypercalcemia in a 9-year-old Brazilian girl due to a novel inactivating mutation of the calcium-sensing receptor.
Topics: Base Sequence; Brazil; Cell Line; Child; Consanguinity; DNA; DNA Restriction Enzymes; Exons; Female; Heterozygote; Homozygote; Humans; Hypercalcemia; Immunoblotting; Leucine; Mutation, Missense; Proline; Receptors, Calcium-Sensing; Severity of Illness Index; Transfection | 2004 |
Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.
Topics: Amino Acid Substitution; Bacillus; Cell Line; Cell Membrane; Cytoplasm; Humans; Ion Channel Gating; Leucine; Membrane Potentials; Mutation; Patch-Clamp Techniques; Proline; Sodium Channels | 2004 |
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
Topics: Actins; Anaphase-Promoting Complex-Cyclosome; Antibodies, Monoclonal; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Lysine; Models, Molecular; Mutation; Mutation, Missense; Neoplasms; Peptides; Plasmids; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Time Factors; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |
Family of two patients with congenital lipoid adrenal hyperplasia due to StAR mutation.
Topics: Adrenal Hyperplasia, Congenital; Animals; Chlorocebus aethiops; COS Cells; Female; Humans; Infant; Leucine; Mutation; Phosphoproteins; Proline; Transfection | 2004 |
Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement.
Topics: Binding Sites; Caprylates; Catalysis; Coenzyme A; Crystallography, X-Ray; Escherichia coli Proteins; Hydrophobic and Hydrophilic Interactions; Leucine; Lysophospholipase; Models, Molecular; Multienzyme Complexes; Palmitoyl-CoA Hydrolase; Periplasmic Proteins; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Substrate Specificity; Thermodynamics | 2005 |
A human congenital myasthenia-causing mutation (epsilon L78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties.
Topics: Acetylcholine; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Humans; Leucine; Likelihood Functions; Mutation; Myasthenic Syndromes, Congenital; Proline; Receptors, Nicotinic | 2005 |
Behavior of diphtheria toxin T domain containing substitutions that block normal membrane insertion at Pro345 and Leu307: control of deep membrane insertion and coupling between deep insertion of hydrophobic subdomains.
Topics: Amino Acid Substitution; Boron Compounds; Diphtheria Toxin; DNA Mutational Analysis; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Leucine; Lipid Bilayers; Membrane Proteins; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Spectrometry, Fluorescence | 2005 |
The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.
Topics: Adult; Amino Acid Substitution; Blood Glucose; Blood Pressure; Female; Genotype; Ghrelin; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Leucine; Male; Mutation, Missense; Neuropeptide Y; Nordefrin; Peptide Hormones; Proline; Protein Precursors | 2005 |
A novel missense mutation in the Connexin 26 gene associated with autosomal recessive sensorineural deafness.
Topics: Alleles; Base Sequence; Child; Connexin 26; Connexins; Conserved Sequence; Cytosine; Female; Genes, Recessive; Hearing Loss, Sensorineural; Homozygote; Humans; Leucine; Mutation, Missense; Point Mutation; Polymorphism, Restriction Fragment Length; Proline; Thymine | 2005 |
The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases.
Topics: Blood Platelets; Densitometry; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Immunoblotting; Integrin beta3; Leucine; Mitogen-Activated Protein Kinase 1; Models, Biological; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Platelet Adhesiveness; Polymorphism, Genetic; Proline; Protein Isoforms; Protein Serine-Threonine Kinases; Signal Transduction; Threonine; Tyrosine | 2005 |
17alpha-hydroxylase/17,20-Lyase deficiency due to novel compound heterozygote mutations: treatment for tall stature in a female with male pseudohermaphroditism and spontaneous puberty in her affected sister.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Arginine; Body Height; Codon, Nonsense; Disorders of Sex Development; Estrogens; Estrogens, Conjugated (USP); Female; Growth Disorders; Heterozygote; Humans; Leucine; Mutation; Mutation, Missense; Orchiectomy; Proline; Puberty; Steroid 17-alpha-Hydroxylase | 2005 |
The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.
Topics: Alleles; Amino Acid Sequence; Animals; Blotting, Western; Calcium; Calcium Channels; Circular Dichroism; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Genetic Vectors; Glutathione Transferase; Histidine; Immunoprecipitation; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Intestinal Mucosa; Kinetics; Leucine; Ligands; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Molecular Sequence Data; Plasmids; Polymorphism, Genetic; Proline; Protein Binding; Protein Structure, Tertiary; Proteolipids; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction; Spectrometry, Fluorescence | 2005 |
Re: Integrin beta3 Leu33Pro homozygosity and risk of cancer.
Topics: Case-Control Studies; Codon; Denmark; Female; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Germany; Homozygote; Humans; Incidence; Integrin beta3; Leucine; Neoplasm Invasiveness; Odds Ratio; Ovarian Neoplasms; Polymorphism, Genetic; Proline; Risk Assessment; Risk Factors; Up-Regulation | 2005 |
Hemangioblastomas of central nervous system: molecular genetic analysis and clinical management.
Topics: Adult; Aged; Arginine; Central Nervous System Neoplasms; DNA Mutational Analysis; Exons; Female; Hemangioblastoma; Humans; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Biology; Mutation, Missense; Proline; Retrospective Studies; Tryptophan; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |
Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men.
Topics: Adult; Alleles; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glucose Intolerance; Heterozygote; Humans; Insulin; Leucine; Male; Middle Aged; Neuropeptide Y; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Sex Characteristics; Sweden | 2005 |
The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.
Topics: Alleles; Case-Control Studies; Exons; Genetic Predisposition to Disease; Genotype; Humans; Leucine; MADS Domain Proteins; Male; MEF2 Transcription Factors; Middle Aged; Mutation; Myocardial Infarction; Myogenic Regulatory Factors; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Proline | 2006 |
No association of breast cancer risk with integrin beta3 (ITGB3) Leu33Pro genotype.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Integrin beta3; Leucine; Middle Aged; Proline | 2005 |
Cell-penetrating cis-gamma-amino-l-proline-derived peptides.
Topics: Alanine; Animals; Cell Membrane; Chlorocebus aethiops; Endocytosis; Flow Cytometry; Gene Products, tat; HeLa Cells; Humans; Leucine; Microscopy, Confocal; Microscopy, Fluorescence; Peptide Hydrolases; Peptides; Phenylalanine; Proline; Temperature | 2005 |
A novel mutation L260P of the steroidogenic acute regulatory protein gene in three unrelated patients of Swiss ancestry with congenital lipoid adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; DNA Mutational Analysis; Female; Humans; Infant; Leucine; Microsatellite Repeats; Mutation, Missense; Pedigree; Phosphoproteins; Pregnenolone; Proline; Switzerland | 2005 |
JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Cloning, Molecular; Cytoplasm; DNA, Complementary; Genes, Dominant; Genetic Vectors; Glutathione Transferase; Immunoprecipitation; Kinesins; Leucine; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Models, Biological; Mutation; Neurons; NIH 3T3 Cells; Peptides; Proline; Protein Binding; Protein Structure, Tertiary; Retroviridae; Signal Transduction; Two-Hybrid System Techniques; Valine | 2005 |
Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects.
Topics: Adult; Analysis of Variance; Female; Gene Frequency; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Japan; Leucine; Male; Middle Aged; Personality; Personality Inventory; Polymorphism, Genetic; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
Topics: Amino Acids; Aminopeptidases; Animals; Binding Sites; Escherichia coli; Kinetics; Leucine; Proline; Protease Inhibitors; Pyrroles; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles | 2005 |
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise.
Topics: Adult; Carbon Radioisotopes; Collagen; Exercise; Hemiterpenes; Humans; Keto Acids; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Myofibrils; Nitrogen Radioisotopes; Patella; Proline; Sarcoplasmic Reticulum; Tendons; Thigh; Valine | 2005 |
Proton affinity of diastereoisomers of modified prolines using the kinetic method and density functional theory calculations: role of the cis/trans substituent on the endo/exo ring conformation.
Topics: Algorithms; Glutamic Acid; Kinetics; Leucine; Models, Molecular; Molecular Conformation; Proline; Stereoisomerism; Thermodynamics | 2005 |
Four novel connexin 32 mutations in X-linked Charcot-Marie-Tooth disease with phenotypic variability.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Charcot-Marie-Tooth Disease; Chromosomes, Human, X; Codon, Terminator; Connexins; DNA Mutational Analysis; Family Health; Female; Gap Junction beta-1 Protein; Humans; Leucine; Male; Middle Aged; Mutation; Phenotype; Phenylalanine; Proline; Serine; Tyrosine; Valine | 2006 |
Resonance assignments for mouse S100A13.
Topics: Animals; Binding Sites; Leucine; Lysine; Magnetic Resonance Spectroscopy; Mice; Proline; Protein Conformation; S100 Proteins | 2005 |
Marked phenotypic variation in a family with a new myelin protein zero mutation.
Topics: Adult; DNA Mutational Analysis; Family Health; Female; Hereditary Sensory and Motor Neuropathy; Humans; Leucine; Male; Mutation; Myelin P0 Protein; Neural Conduction; Pedigree; Phenotype; Proline | 2005 |
Effect of individual amino acids and glucose on activation and germination of Rhizopus oligosporus sporangiospores in tempe starter.
Topics: Alanine; Amino Acids; Arginine; Betaine; Colony Count, Microbial; Culture Media; Food Handling; Food Microbiology; Germination; Glucose; Glycine max; Isoleucine; Leucine; Phosphates; Proline; Rhizopus; Spores, Fungal | 2005 |
Effect of latanoprost on cultured porcine corneal stromal cells.
Topics: Animals; Benzalkonium Compounds; Calcium; Cell Movement; Cells, Cultured; Collagen Type I; Corneal Stroma; Fibronectins; Fluorescent Antibody Technique; Immunoblotting; Intracellular Membranes; Latanoprost; Leucine; Proline; Prostaglandins F, Synthetic; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Thymidine; Uridine | 2005 |
Increased risk of ovarian cancer in integrin beta3 Leu33Pro homozygotes.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Case-Control Studies; Female; Genetic Predisposition to Disease; Homozygote; Humans; Integrin beta3; Leucine; Middle Aged; Odds Ratio; Ovarian Neoplasms; Proline; Risk Factors | 2005 |
Induction of a protein-targeted catalytic response in autoimmune prone mice: antibody-mediated cleavage of HIV-1 glycoprotein GP120.
Topics: Animals; Antibodies, Catalytic; Antibody Affinity; Autoimmune Diseases; Catalysis; Electrophoresis, Polyacrylamide Gel; Encephalomyelitis, Autoimmune, Experimental; Fluorescent Dyes; HIV Envelope Protein gp120; HIV-1; Immunoglobulin G; Leucine; Mice; Peptide Fragments; Proline; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Viral Vaccines | 2006 |
Biochemical activities of the BOB1 mutant in Methanobacterium thermoautotrophicum MCM.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Binding Sites; Cell Cycle Proteins; Cloning, Molecular; Conserved Sequence; DNA Helicases; DNA, Archaeal; DNA, Mitochondrial; DNA, Single-Stranded; Evolution, Molecular; Leucine; Methanobacterium; Minichromosome Maintenance 1 Protein; Proline; Saccharomyces cerevisiae Proteins | 2006 |
Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Electrophysiology; Immunohistochemistry; Kinetics; Leucine; Light; Mutation; Proline; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Rhodopsin; Swine; Vision, Ocular | 2005 |
Factor XIIIa mediated attachment of S. aureus fibronectin-binding protein A (FnbA) to fibrin: identification of Gln103 as a major cross-linking site.
Topics: Adhesins, Bacterial; Base Sequence; Binding Sites; Catalysis; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Factor XIIIa; Fibrin; Glutamine; Leucine; Lysine; Proline; Staphylococcus aureus; Time Factors; Urea | 2006 |
Phenotypic and cellular expression of two novel connexin32 mutations causing CMT1X.
Topics: Aged; Amino Acid Substitution; Central Nervous System Diseases; Charcot-Marie-Tooth Disease; Connexins; Demyelinating Diseases; Electromyography; Female; Gap Junction beta-1 Protein; Glutamic Acid; HeLa Cells; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Neural Conduction; Pedigree; Phenotype; Polyneuropathies; Proline; Sural Nerve; Valine | 2006 |
Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population.
Topics: Adult; Aged; Aged, 80 and over; Asparagine; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Glucosylceramidase; Heterozygote; Humans; Leucine; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Serine | 2006 |
Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1).
Topics: Acidosis, Renal Tubular; Adult; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Cell Membrane; Eye Diseases; Homozygote; Humans; Leucine; Male; Molecular Sequence Data; Mutation, Missense; Oocytes; Proline; Sodium-Bicarbonate Symporters; Xenopus | 2006 |
Presymptomatic genetic diagnosis for consulters from a large Chinese family with juvenile open angle glaucoma.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Asian People; Cytoskeletal Proteins; Eye Proteins; Female; Genes, Dominant; Genetic Predisposition to Disease; Glaucoma, Open-Angle; Glycoproteins; Heterozygote; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Phenotype; Proline | 2006 |
Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa.
Topics: Asian People; c-Mer Tyrosine Kinase; DNA Mutational Analysis; Exons; Gene Frequency; Genes, Recessive; Homozygote; Humans; Introns; Leucine; Mutation; Mutation, Missense; Proline; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Retinitis Pigmentosa | 2006 |
Role of the C-terminal fragment of human transthyretin in abnormal fibrillogenesis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Humans; Leucine; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Prealbumin; Proline; Protease Inhibitors; Protein Binding; Protein Structure, Quaternary; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer.
Topics: Alcohol Drinking; Cohort Studies; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Lung Neoplasms; Middle Aged; Polymorphism, Genetic; Proline; Risk Factors; Smoking | 2007 |
Clinical features of hereditary spastic paraplegia due to spastin mutation.
Topics: Adenosine Triphosphatases; Adult; Aged; Cohort Studies; DNA Mutational Analysis; Exons; Female; Genetic Testing; Glutamine; Humans; Leucine; Male; Middle Aged; Mutation; Phenotype; Proline; Retrospective Studies; Serine; Spastic Paraplegia, Hereditary; Spastin; United Kingdom | 2006 |
Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside Europe.
Topics: Cytosine; Europe; Female; Genetic Predisposition to Disease; Granuloma; Humans; Leucine; Male; Peptidyl-Dipeptidase A; Point Mutation; Proline; Thymine | 2006 |
Molecular assay for detection of the common carnitine palmitoyltransferase 1A 1436(C>T) mutation.
Topics: Amino Acid Substitution; Base Sequence; Biological Assay; Carnitine O-Palmitoyltransferase; Cytosine; Female; Genotype; Heterozygote; Humans; Infant; Leucine; Lipid Metabolism; Male; Point Mutation; Proline; Reverse Transcriptase Polymerase Chain Reaction; Thymine | 2006 |
Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area.
Topics: Animals; Calcium; Hindlimb; Humans; Kinetics; Leucine; Malignant Hyperthermia; Models, Genetic; Models, Molecular; Mutation; Proline; Protein Structure, Secondary; Rabbits; Ryanodine Receptor Calcium Release Channel | 2007 |
Late-onset metachromatic leukodystrophy: genotype strongly influences phenotype.
Topics: Adolescent; Adult; Cerebroside-Sulfatase; Child; Electroencephalography; Female; Genotype; Humans; Isoleucine; Leucine; Leukodystrophy, Metachromatic; Magnetic Resonance Imaging; Male; Mutation; Neural Conduction; Phenotype; Proline; Statistics, Nonparametric | 2006 |
A novel mutation of PAX3 in a Chinese family with Waardenburg syndrome.
Topics: Amino Acid Substitution; Asian People; Child, Preschool; Chromosomes, Human, Pair 2; Cytosine; DNA Mutational Analysis; Female; Genetic Linkage; Haplotypes; Heterozygote; Humans; Leucine; Lod Score; Male; Mutation; Paired Box Transcription Factors; PAX3 Transcription Factor; Pedigree; Phenotype; Proline; Thymine; Waardenburg Syndrome | 2006 |
Can mutations in gamma-actin modulate the toxicity of microtubule targeting agents?
Topics: Actins; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leucine; Microtubules; Mutation; Neoplasms; Proline; RNA, Small Interfering; Tubulin; Tubulin Modulators; Valine; Vincristine | 2006 |
Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia.
Topics: Actins; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Child; DNA Mutational Analysis; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Epothilones; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Leucine; Mass Spectrometry; Mice; Microtubules; Mutation; Neuroblastoma; Plasmids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection; Tubulin; Tubulin Modulators; Tumor Stem Cell Assay; Valine; Vinblastine | 2006 |
Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains.
Topics: Amino Acid Motifs; Carrier Proteins; Humans; Huntington Disease; Leucine; Ligands; Magnetic Resonance Spectroscopy; Peptides; Proline; Proline-Rich Protein Domains; Protein Structure, Tertiary; Rett Syndrome; Ribonucleoprotein, U1 Small Nuclear; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Tryptophan | 2006 |
Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome.
Topics: Brugada Syndrome; Genetic Carrier Screening; Humans; Isoleucine; Leucine; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Pedigree; Phenotype; Proline; Sodium Channels; Valine | 2006 |
Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; MADS Domain Proteins; Male; MEF2 Transcription Factors; Middle Aged; Myogenic Regulatory Factors; Odds Ratio; Peptides; Polymorphism, Genetic; Proline | 2007 |
Identification of a novel mutation in the spastin gene (SPG4) in an Italian family with hereditary spastic paresis.
Topics: Adenosine Triphosphatases; Adult; Aged; Cytosine; Exons; Female; Genes, Dominant; Humans; Italy; Leucine; Magnetic Resonance Imaging; Male; Mutation, Missense; Proline; Spastic Paraplegia, Hereditary; Spastin; Thymine | 2006 |
A novel P755L mutation in LRRK2 gene associated with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population.
Topics: Alleles; Asian People; China; Female; Humans; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Sequence Analysis, DNA; Stomach Neoplasms; Transforming Growth Factor beta1; Transforming Growth Factor beta2 | 2007 |
Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
Topics: Adult; Aged; Aged, 80 and over; Alleles; BRCA1 Protein; Breast Neoplasms; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Integrin beta3; Leucine; Middle Aged; Ovarian Neoplasms; Polymorphism, Genetic; Proline | 2007 |
A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect.
Topics: Aspartic Acid; Binding Sites; Blood Coagulation; Catalysis; Chymotrypsin; Factor XI; Humans; Kinetics; Leucine; Models, Molecular; Proline; Protein Binding; Recombinant Proteins; Serine Endopeptidases | 2007 |
Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.
Topics: Alleles; Amino Acid Substitution; Carcinoma; Case-Control Studies; Colorectal Neoplasms; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Interleukin-10; Italy; Leucine; Male; Polymorphism, Single Nucleotide; Proline; Risk; Transforming Growth Factor beta1 | 2006 |
Integrin beta3 Leu33Pro polymorphism and risk of hip fracture: 25 years follow-up of 9233 adults from the general population.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Bone Density; Denmark; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Hip Fractures; Homozygote; Humans; Integrin beta3; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Prospective Studies; Risk Factors | 2007 |
Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.
Topics: Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Ghrelin; Humans; Hypertension; Insulin; Insulin Secretion; Leucine; Male; Middle Aged; Neuropeptide Y; Peptide Hormones; Polymorphism, Genetic; Proline; Protein Precursors; Risk Factors | 2007 |
Two novel epilepsy-linked mutations leading to a loss of function of LGI1.
Topics: Adult; Blotting, Western; DNA Mutational Analysis; Epilepsy; Exons; Family Health; Female; Genetic Linkage; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Mutation; Proline; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index | 2007 |
Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration.
Topics: Aged; Aged, 80 and over; Amino Acid Substitution; Exudates and Transudates; Female; Genotype; Humans; Leucine; Macular Degeneration; Male; Neuropeptide Y; Polymerase Chain Reaction; Polymorphism, Genetic; Proline; Protein Sorting Signals; Risk Factors | 2007 |
Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cells.
Topics: Animals; Calcium Channels, L-Type; Caveolin 3; Cells, Cultured; Electric Conductivity; Embryo, Mammalian; Leucine; Mice; Muscle Cells; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies; Mutation; Proline; Tissue Distribution | 2007 |
Amino acid and codon use: in two influenza viruses and three hosts.
Topics: Alanine; Amino Acids; Animals; Chickens; Codon; Humans; Influenza A virus; Influenza B virus; Leucine; Proline; Swine | 2007 |
Unique side chain conformation of a Leu residue in a triple-helical structure.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Glycine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Hypoxanthine; Leucine; Models, Chemical; Oligopeptides; Oxygen; Proline; Protein Conformation; Protein Structure, Secondary; Water | 2007 |
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer.
Topics: Amino Acid Sequence; Cell Line; Herpesvirus 8, Human; Humans; Immediate-Early Proteins; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Open Reading Frames; Proline; Protein Structure, Quaternary; Sarcoma, Kaposi; Trans-Activators; Viral Proteins; Virus Activation | 2007 |
The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in
Topics: Amino Acid Substitution; Animals; Catalysis; Cathepsins; Dicrocoelium; Enzyme Activation; Enzyme Precursors; Helminth Proteins; Hydrogen-Ion Concentration; Leucine; Mutation, Missense; Proline; Protein Processing, Post-Translational | 2007 |
Structural and functional basis of amino acid specificity in the invertebrate cotransporter KAAT1.
Topics: Amino Acid Sequence; Amino Acid Transport Systems, Neutral; Amino Acids; Animals; Binding, Competitive; Carrier Proteins; Computer Simulation; Female; Insect Proteins; Kinetics; Leucine; Manduca; Membrane Potentials; Membrane Proteins; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Patch-Clamp Techniques; Potassium; Proline; Protein Binding; Protein Conformation; Sodium; Threonine; Xenopus laevis | 2007 |
Myocilin mutations among primary open angle glaucoma patients of Kanyakumari district, South India.
Topics: Aged; Asian People; Base Sequence; Cytoskeletal Proteins; Eye Proteins; Female; Glaucoma, Open-Angle; Glycoproteins; Humans; India; Leucine; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Proline; Serine; Threonine; Tyrosine | 2007 |
Role of chromosomal and plasmid-borne receptor homologues in the response of Bacillus megaterium QM B1551 spores to germinants.
Topics: Bacillus megaterium; Bacterial Proteins; Biological Transport; Bromides; Chromosomes, Bacterial; DNA, Bacterial; Genes, Bacterial; Genetic Complementation Test; Glucose; Leucine; Membrane Proteins; Molecular Sequence Data; Operon; Plasmids; Potassium Compounds; Proline; Sequence Analysis, DNA; Sequence Deletion; Spores, Bacterial; Transformation, Bacterial | 2007 |
The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components.
Topics: Acholeplasma laidlawii; Amino Acid Sequence; Amino Acid Substitution; Bacteria; Cell Line; Cell Wall; Genetic Variation; Humans; Immunity, Innate; Leucine; Lipoproteins; Molecular Sequence Data; Mycobacterium smegmatis; Polymorphism, Single Nucleotide; Porphyromonas gingivalis; Proline; Toll-Like Receptor 1 | 2007 |
The rare Hb Showa-Yakushiji [beta110(G12)Leu-->Pro, CTG-->CCG] in combination with an alpha gene triplication found in a Dutch patient during her first pregnancy examination.
Topics: Adult; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; DNA; Female; Hemoglobins, Abnormal; Humans; Leucine; Mutation; Polymorphism, Single Nucleotide; Pregnancy; Proline | 2007 |
Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.
Topics: Arginine; Asian People; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; Exons; Gene Frequency; Genotype; Glutamic Acid; Humans; Introns; Japan; Leucine; Polymorphism, Single Nucleotide; Proline | 2007 |
Pro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecular meshwork cells.
Topics: Adult; Cells, Cultured; Cytoskeletal Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Eukaryotic Initiation Factor-2; Eye Proteins; Glycoproteins; Heat-Shock Proteins; Humans; Leucine; Membrane Potential, Mitochondrial; Molecular Chaperones; Mutation; Phosphorylation; Proline; RNA, Messenger; Stress, Physiological; Trabecular Meshwork; Transfection | 2007 |
Impact of the Leu7Pro polymorphism of preproNPY on diurnal NPY and hormone secretion in type 2 diabetes.
Topics: Aged; Amino Acid Substitution; Blood Glucose; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Female; Humans; Hydrocortisone; Leptin; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Precursors | 2007 |
Enzyme replacement therapy in 12 patients with MPS I-H/S with homozygous p.Leu490Pro mutation.
Topics: Adolescent; Adult; Child; Child, Preschool; Cohort Studies; Female; Homozygote; Humans; Iduronidase; Leucine; Male; Mucopolysaccharidosis I; Mutation, Missense; Pakistan; Pedigree; Proline; Recombinant Proteins; Treatment Outcome; United Kingdom | 2007 |
Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site.
Topics: Alanine; Binding Sites; Kinetics; Leucine; Proline; Protein Conformation; Protein Structure, Tertiary; Receptor, PAR-1; Receptors, Thrombin; Recombinant Fusion Proteins; Thrombin | 2007 |
Enhanced preference for pi-bond containing substrates is correlated to Pro110 in the substrate-binding tunnel of Escherichia coli thioesterase I/protease I/lysophospholipase L(1).
Topics: Amino Acid Substitution; Escherichia coli; Escherichia coli Proteins; Leucine; Lysophospholipase; Mutation, Missense; Periplasmic Proteins; Proline; Protein Structure, Tertiary; Substrate Specificity; Triglycerides | 2007 |
[A novel mutation in infant hypophophatasia: a case report].
Topics: Alkaline Phosphatase; Exons; Follow-Up Studies; Homozygote; Humans; Hypophosphatasia; Infant; Leucine; Male; Mutation; Proline | 2007 |
Adult onset cerebral form of X-linked adrenoleukodystrophy with dementia of frontal lobe type with new L160P mutation in ABCD1 gene.
Topics: Adrenoleukodystrophy; Adult; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Dementia; Disease Progression; DNA Mutational Analysis; Family Health; Female; Follow-Up Studies; Humans; Leucine; Magnetic Resonance Imaging; Male; Mutation; Proline | 2007 |
Study of antibodies to PMP22, IL-6 and TNF-alpha concentrations in serum in a CMTX1 family.
Topics: Antibodies; Charcot-Marie-Tooth Disease; China; Chromosomes, Human, X; Connexins; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Family Health; Female; Gap Junction beta-1 Protein; Humans; Interleukin-6; Leucine; Male; Myelin Proteins; Point Mutation; Proline; Sex Factors; Tumor Necrosis Factor-alpha | 2007 |
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
Topics: Age Factors; Analysis of Variance; Animals; Antibodies; Behavior, Animal; Brain; Cell Line, Tumor; Dementia; Disease Models, Animal; Humans; Immunotherapy; Leucine; Mice; Mice, Transgenic; Motor Activity; Neuroblastoma; Proline; Psychomotor Performance; Recognition, Psychology; Sex Factors; tau Proteins | 2007 |
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
Topics: Adult; Age of Onset; Aged; Asian People; Black or African American; Breast Neoplasms; Case-Control Studies; Checkpoint Kinase 2; DNA Mutational Analysis; DNA, Complementary; Female; Gene Frequency; Genetic Predisposition to Disease; Germ-Line Mutation; Hawaii; Hispanic or Latino; Histidine; Humans; Isoleucine; Leucine; Male; Middle Aged; Mutation; Mutation, Missense; Predictive Value of Tests; Proline; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Risk Assessment; Risk Factors; Threonine; Tyrosine; United States; White People | 2007 |
MYOC gene mutations in Spanish patients with autosomal dominant primary open-angle glaucoma: a founder effect in southeast Spain.
Topics: Adolescent; Adult; Age of Onset; Child; Child, Preschool; Colombia; Cytoskeletal Proteins; Eye Proteins; Female; Founder Effect; Genes, Dominant; Glaucoma, Open-Angle; Glycoproteins; Haplotypes; Humans; Leucine; Male; Middle Aged; Mutation; Pedigree; Phenotype; Proline; Retrospective Studies; Spain | 2007 |
An unusual presentation of macular corneal dystrophy associated with uniparental isodisomy and a novel Leu173Pro mutation.
Topics: Adult; Amino Acid Sequence; Carbohydrate Sulfotransferases; Conserved Sequence; Cornea; Corneal Dystrophies, Hereditary; Genotype; Homozygote; Humans; Keratan Sulfate; Leucine; Male; Mutation; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Sulfotransferases; Uniparental Disomy | 2007 |
Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.
Topics: Amino Acid Transport Systems, Neutral; Animals; Behavior, Animal; Biological Transport, Active; Cysteine; DNA Primers; Gene Deletion; Hydrogen-Ion Concentration; Leucine; Maze Learning; Mice; Mice, Knockout; Motor Activity; Phenotype; Postural Balance; Proline; Psychomotor Performance; Smell; Synaptosomes | 2007 |
Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu.
Topics: Aminopeptidases; Binding Sites; Biochemistry; Crystallography, X-Ray; Escherichia coli; Leucine; Models, Chemical; Molecular Conformation; Mutation; Peptides; Proline; Substrate Specificity; Valine | 2008 |
Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Single Nucleotide; Proline; Sweden; United States | 2007 |
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
Topics: Amino Acid Substitution; DNA; DNA Polymerase beta; DNA Repair; Humans; Kinetics; Leucine; Models, Molecular; Phosphorus-Oxygen Lyases; Proline; Schiff Bases; Stomach Neoplasms | 2008 |
Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery atherosclerosis: the Helsinki Sudden Death Study.
Topics: Adult; Aged; Autopsy; Coronary Artery Disease; Gene Expression Regulation; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Sorting Signals; Risk | 2008 |
Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy.
Topics: Aged; Asparagine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glucosylceramidase; Humans; Italy; Leucine; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Serine | 2008 |
Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts.
Topics: Androstadienes; Animals; Atrial Natriuretic Factor; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Insulin-Like Growth Factor I; Leucine; Male; Molecular Structure; Myocytes, Cardiac; Phenanthrenes; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2008 |
What causes paramyotonia in the United Kingdom? Common and new SCN4A mutations revealed.
Topics: Action Potentials; Arginine; Cohort Studies; Exons; Female; Humans; Leucine; Male; Mutation; Myotonic Disorders; NAV1.4 Voltage-Gated Sodium Channel; Neural Conduction; Proline; Sodium Channels; United Kingdom | 2008 |
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Alleles; Cardiovascular Diseases; Child; Child Nutritional Physiological Phenomena; Cholesterol, LDL; Female; Finland; Genetic Predisposition to Disease; Genotype; Health Education; Humans; Leucine; Lipids; Male; Neuropeptide Y; Overweight; Polymorphism, Genetic; Proline; Public Health; Risk Factors; Sex Factors; Thinness | 2008 |
Spermatogenic and steroidogenic impairment of the testicle characterizes the hereditary leucine-75-proline apolipoprotein a-I amyloidosis.
Topics: Adult; Aged; Amyloidosis, Familial; Apolipoprotein A-I; Humans; Leucine; Lipids; Male; Middle Aged; Proline; Spermatogenesis; Steroids; Testis | 2008 |
Morphology of the sella turcica in Axenfeld-Rieger syndrome with PITX2 mutation.
Topics: Adolescent; Cephalometry; Chromosomes, Human, Pair 13; Codon; Cranial Fossa, Posterior; Craniofacial Abnormalities; Cytosine; Eye Abnormalities; Facial Bones; Female; Forkhead Transcription Factors; Heterozygote; Homeobox Protein PITX2; Homeodomain Proteins; Humans; Leucine; Male; Malocclusion, Angle Class III; Maxilla; Middle Aged; Mutation, Missense; Proline; Sella Turcica; Syndrome; Thymine; Tooth Abnormalities; Transcription Factors; Young Adult | 2008 |
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
Topics: Aged; Asparagine; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glucosylceramidase; Humans; Leucine; Lewy Body Disease; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Risk Factors; Serine | 2008 |
Metachromatic leukodystrophy: genetics, pathogenesis and therapeutic options.
Topics: Animals; Disease Models, Animal; Hematopoietic Stem Cell Transplantation; Humans; Leucine; Leukodystrophy, Metachromatic; Mice; Mice, Transgenic; Mutation, Missense; Phenotype; Proline | 2008 |
Matched regulation of gastrointestinal performance in the Burmese python, Python molurus.
Topics: alpha-Glucosidases; Aminopeptidases; Amylases; Animals; Biological Transport; Boidae; Feeding Behavior; Gastric Mucosa; Gastrointestinal Tract; Glucose; Intestines; Leucine; Myanmar; Organ Size; Pancreas; Pepsin A; Proline; Trypsin | 2008 |
Parkinson's disease and the heterozygous state for glucocerebrosidase mutations among Brazilians.
Topics: Adult; Asparagine; Brazil; Female; Glucosylceramidase; Heterozygote; Humans; Leucine; Male; Middle Aged; Mutation; Parkinson Disease; Proline; Serine | 2009 |
Charcot-Marie-Tooth disease type 4C4 caused by a novel Pro153Leu substitution in the GDAP1 gene.
Topics: Adult; Amino Acid Sequence; Charcot-Marie-Tooth Disease; Genotype; GTP Phosphohydrolases; Humans; Leucine; Male; Membrane Proteins; Membrane Transport Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscular Atrophy; Mutation; Nerve Tissue Proteins; Phenotype; Poland; Proline | 2007 |
Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.
Topics: Age Factors; Aged; Aged, 80 and over; Animals; Brain; Calcium-Binding Proteins; DNA-Binding Proteins; Female; Histocompatibility Antigens Class II; Humans; Leucine; Male; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Microscopy, Electron, Transmission; Middle Aged; Mutation; Proline; Receptors, Scavenger; tau Proteins; Tauopathies | 2008 |
Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R(P132L) show the different intracellular localization in vitro.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Cyclic AMP; Gene Expression Regulation; Humans; Intracellular Space; Leucine; Mice; Osteochondrodysplasias; Parathyroid Hormone; Proline; Protein Transport; Rats; Receptor, Parathyroid Hormone, Type 1 | 2008 |
Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort.
Topics: Adipose Tissue; Adult; Aged; Amino Acid Substitution; Body Size; Cohort Studies; DNA Primers; Female; Gene Frequency; Genetic Variation; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Insulin Resistance; Japan; Leucine; Longevity; Longitudinal Studies; Male; Metabolic Syndrome; Middle Aged; Polymorphism, Single Nucleotide; Proline; Sex Characteristics | 2008 |
Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype.
Topics: Adult; Age of Onset; Aged; Amino Acid Sequence; Animals; Asian People; China; Chromosomes, Human, Pair 1; Cytoskeletal Proteins; Eye; Eye Proteins; Family; Female; Glaucoma, Open-Angle; Glycoproteins; Haplotypes; Humans; Leucine; Lod Score; Male; Microsatellite Repeats; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Phenotype; Proline | 2008 |
The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine.
Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Animals; CHO Cells; Cricetinae; Cricetulus; Glycine; Humans; In Vitro Techniques; Leucine; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; PC12 Cells; Proline; Rats; RNA, Small Interfering; Synaptic Vesicles | 2008 |
A novel LMNA gene mutation Leu162Pro and the associated clinical characteristics in a family with autosomal-dominant emery-dreifuss muscular dystrophy.
Topics: Adult; Age of Onset; Amino Acid Substitution; Chromatin; Chromosome Disorders; DNA Mutational Analysis; Endothelial Cells; Female; Genes, Recessive; Genetic Markers; Genetic Predisposition to Disease; Humans; Lamin Type A; Leucine; Male; Muscle, Skeletal; Muscular Dystrophy, Emery-Dreifuss; Nuclear Envelope; Pedigree; Point Mutation; Proline | 2008 |
Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase.
Topics: Amino Acid Substitution; Ampicillin; beta-Lactamases; Crystallography, X-Ray; Enzyme Stability; Escherichia coli; Hydrolysis; Kinetics; Leucine; Microbial Sensitivity Tests; Microbial Viability; Mutant Proteins; Periplasmic Proteins; Plasmids; Proline; Protein Structure, Secondary; Selection, Genetic; Suppression, Genetic; Thermodynamics | 2008 |
Absolute side-chain structure at position 13 is required for the inhibitory activity of bromein.
Topics: Amino Acid Sequence; Ananas; Bromelains; Circular Dichroism; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Leucine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Proline; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Threonine | 2008 |
Altered functional properties of a TRPM2 variant in Guamanian ALS and PD.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Calcium; Calcium Signaling; Cell Membrane; Conserved Sequence; Cyanobacteria Toxins; Evolution, Molecular; Guam; Humans; Hydrogen Peroxide; Ion Channel Gating; Leucine; Magnesium; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Mutation; Oxidative Stress; Parkinsonian Disorders; Proline; Temperature; TRPM Cation Channels | 2008 |
The intracellular mobility of NPY and a putative mitochondrial form of NPY in neuronal cells.
Topics: Cell Line, Tumor; Green Fluorescent Proteins; Humans; Leucine; Microscopy, Confocal; Mitochondria; Neuroblastoma; Neurons; Neuropeptide Y; Polymorphism, Genetic; Proline; Protein Transport; Transfection | 2009 |
Association of mild and severely unstable alpha chain variants: the first observation of a compound heterozygote with Hb Setif [alpha94(G1)Asp-->Tyr (alpha2)] and Hb Agrinio [alpha29(B10)Leu-->Pro (alpha2)] in a Greek family.
Topics: Adult; alpha-Globins; Amino Acid Substitution; Anemia; Aspartic Acid; Child; Child, Preschool; Female; Greece; Hemoglobins, Abnormal; Heterozygote; Humans; Leucine; Male; Middle Aged; Proline; Tyrosine | 2008 |
Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.
Topics: Adenylate Kinase; Crystallography, X-Ray; Humans; Leucine; Mutation; Proline; Protein Structure, Tertiary | 2009 |
Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation.
Topics: Amino Acid Substitution; Cardiac Myosins; Cardiomyopathies; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Heart; Humans; Leucine; Middle Aged; Muscle Hypotonia; Muscle, Skeletal; Muscular Diseases; Mutation; Myocardium; Myosin Heavy Chains; Phenotype; Proline; Young Adult | 2009 |
Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cattle; Cell Line, Tumor; Green Fluorescent Proteins; Leucine; Models, Molecular; Mutagenesis; Mutation; Neuroblastoma; Oocytes; Proline; Protein Structure, Secondary; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Transfection; Xenopus | 2009 |
Subcortical projections of the inferior parietal cortex (area 7) in the stump-tailed monkey.
Topics: Animals; Brain Mapping; Leucine; Macaca; Neural Pathways; Parietal Lobe; Proline; Tritium | 1984 |
Topographic organization of the ventral striatal efferent projections in the rhesus monkey: an anterograde tracing study.
Topics: Animals; Autoradiography; Basal Ganglia; Efferent Pathways; Female; Globus Pallidus; Leucine; Macaca mulatta; Microinjections; Neural Pathways; Nucleus Accumbens; Phytohemagglutinins; Proline; Substantia Nigra; Tritium | 1990 |
Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation.
Topics: Alleles; Amino Acid Substitution; Base Sequence; Cerebellar Neoplasms; Cerebellopontine Angle; Chromosome Deletion; Codon; Diagnosis, Differential; DNA Mutational Analysis; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Neoplasms, Multiple Primary; Neuroma, Acoustic; Paraganglioma; Proline; Radiography; Radiosurgery; Succinate Dehydrogenase | 2008 |
The role of non-synonymous NPY gene polymorphism in the nitric oxide production in HUVECs.
Topics: Cells, Cultured; Endothelium, Vascular; Humans; Leucine; Neuropeptide Y; Nitric Oxide; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Proline; RNA, Messenger; Umbilical Veins | 2009 |
Stereochemical preference in the reactions of N-protected L-amino acid 1-hydroxybenzotriazole esters with racemic amino acid derivatives.
Topics: Amino Acids; Esters; Leucine; Proline; Stereoisomerism; Triazoles | 2009 |
Toward an antitumor form of bovine pancreatic ribonuclease: the crystal structure of three noncovalent dimeric mutants.
Topics: Animals; Antineoplastic Agents; Catalytic Domain; Cattle; Crystallography, X-Ray; Cysteine; Endoribonucleases; Glycine; Isoenzymes; Leucine; Male; Models, Molecular; Mutation; Proline; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Recombinant Proteins; Ribonuclease, Pancreatic; Ribonucleases; Structure-Activity Relationship | 2009 |
Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid chromatography with tandem mass spectrometric detection.
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Cyclopropanes; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Polysorbates; Proline; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Surface-Active Agents; Tandem Mass Spectrometry; Viral Nonstructural Proteins | 2009 |
Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation.
Topics: Amino Acid Substitution; Breast Neoplasms; Caveolin 1; Cell Differentiation; Epithelial Cells; Female; Humans; Immunohistochemistry; Leucine; Mutation; Proline; Protein Transport | 2009 |
Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population.
Topics: Adolescent; Adult; Asian People; Black or African American; Cephalometry; China; Cysteine; Exons; Female; Gene Deletion; Gene Frequency; Genotype; Haplotypes; Hispanic or Latino; Humans; Isoleucine; Japan; Korea; Leucine; Linkage Disequilibrium; Male; Mandible; Maxilla; Middle Aged; Phenylalanine; Polymorphism, Single Nucleotide; Proline; Protein Isoforms; Receptors, Somatotropin; Skull Base; Threonine; White People; Young Adult | 2009 |
CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Catalase; Female; Gene Frequency; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Middle Aged; Polymorphism, Single Nucleotide; Proline; Turkey; Young Adult | 2010 |
Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety.
Topics: Anticoagulants; Computer Simulation; Crystallography, X-Ray; Leucine; Proline; Protein Binding; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thrombin; Trypsin | 2009 |
Metastable atom-activated dissociation mass spectrometry: leucine/isoleucine differentiation and ring cleavage of proline residues.
Topics: Angiotensin II; Bradykinin; Cholecystokinin; Dipeptides; Fibrinopeptide B; Isoleucine; Leucine; Mass Spectrometry; Peptide Fragments; Phosphoproteins; Proline; Proteins; Substance P | 2009 |
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Endoplasmic Reticulum, Rough; Female; Humans; Leucine; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Mitochondria; Mutation; Proline; Qa-SNARE Proteins; Receptors, Peptide; Spinal Cord; Subcellular Fractions; tau Proteins | 2009 |
Confirmation of allele HLA-A*3116 found in a family of a leukaemia patient with Caucasian and Caribbean origin.
Topics: Alleles; Amino Acid Substitution; Base Sequence; Black People; Caribbean Region; Female; HLA-A Antigens; Humans; Leucine; Male; Molecular Sequence Data; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proline; Sequence Homology, Nucleic Acid; White People | 2009 |
Structural and mechanistic roles of three consecutive Pro residues of porcine NADH-cytochrome b(5) reductase for the binding of beta-NADH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cytochrome-B(5) Reductase; Cytochromes b5; DNA Primers; Kinetics; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Proline; Protein Binding; Protein Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine | 2009 |
Association between transforming growth factor beta1 polymorphisms and left ventricle hypertrophy in essential hypertensive subjects.
Topics: Arginine; Asian People; Codon; Genotype; Humans; Hypertension; Hypertrophy, Left Ventricular; Leucine; Mutation; Polymorphism, Genetic; Proline; Transforming Growth Factor beta1 | 2010 |
Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme.
Topics: Alanine; Alleles; Antioxidants; Breast Neoplasms; Codon; DNA Damage; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Lymphocytes; Mutagenesis; Polymorphism, Genetic; Proline; Selenium | 2009 |
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Topics: Animals; Antiviral Agents; Area Under Curve; Cell Line; Cyclopropanes; Dogs; Genotype; Half-Life; Hepacivirus; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams, Macrocyclic; Leucine; Macaca mulatta; Pan troglodytes; Proline; Protease Inhibitors; Rats; Recombinant Proteins; Replicon; Substrate Specificity; Sulfonamides; Viral Nonstructural Proteins | 2010 |
AMINO ACID COMPOSITION OF HIGHLY PURIFIED VIRAL PARTICLES OF INFLUENZA A AND B.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Humans; Influenza, Human; Isoleucine; Leucine; Lysine; Methionine; Orthomyxoviridae; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine; Virion | 1947 |
Novel P2-P4 macrocyclic inhibitors of HCV NS3/4A protease by P3 succinamide fragment depeptidization strategy.
Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Binding Sites; Cell Line; Computer Simulation; Cyclopropanes; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Protease Inhibitors; Rats; Rats, Wistar; Succinates; Sulfonamides; Viral Nonstructural Proteins | 2010 |
Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration.
Topics: Adenosine Triphosphate; Age Factors; Animals; Apoptosis; Apoptosis Inducing Factor; Brain; Caspase 3; Electron Transport Complex I; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; In Situ Nick-End Labeling; Leucine; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Movement Disorders; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Oxidative Stress; Proline; Proton Pumps; Silver Staining; Statistics, Nonparametric; tau Proteins; Tauopathies | 2011 |
Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1.
Topics: Alzheimer Disease; Amino Acid Substitution; Apoptosis; Calcium; Calcium Channels; Endoplasmic Reticulum; HeLa Cells; Humans; Kinetics; Leucine; Membrane Glycoproteins; Mitochondria; Mutation; Proline | 2010 |
CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Calcium Channels; Case-Control Studies; China; Female; Humans; Leucine; Male; Membrane Glycoproteins; Polymorphism, Genetic; Proline; Risk Factors | 2010 |
Inverse correlation of thermal lability and conversion efficiency for five prion protein polymorphic variants.
Topics: Amino Acid Substitution; Animals; Cell-Free System; Deer; Genetic Predisposition to Disease; Genetic Variation; Immunity, Innate; Leucine; Mice; Peptide Fragments; Polymorphism, Genetic; Prion Diseases; Prions; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Stability; Sheep; Temperature | 2010 |
Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
Topics: Acetic Acid; Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Caproates; Carboxylic Ester Hydrolases; Catalytic Domain; Crystallization; Crystallography, X-Ray; Diffusion; Esters; Hydrogen Peroxide; Hydrolysis; Lactones; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Pseudomonas fluorescens | 2010 |
Glucocerebrosidase gene L444P mutation is a risk factor for Parkinson's disease in Chinese population.
Topics: Adult; Asian People; Case-Control Studies; Chi-Square Distribution; DNA Mutational Analysis; Female; Glucosylceramidase; Humans; Leucine; Male; Meta-Analysis as Topic; Middle Aged; Mutation; Parkinson Disease; Proline | 2010 |
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
Topics: Animals; Area Under Curve; Carrier Proteins; Cyclopropanes; Dogs; Drug Discovery; Drug Evaluation, Preclinical; Hepacivirus; Indoles; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams, Macrocyclic; Leucine; Liver; Macaca mulatta; Macrocyclic Compounds; Metabolic Clearance Rate; Models, Chemical; Molecular Structure; Pan troglodytes; Proline; Rats; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins; Viral Proteins | 2010 |
L-Proline induces differentiation of ES cells: a novel role for an amino acid in the regulation of pluripotent cells in culture.
Topics: Animals; Cell Line; Embryonic Stem Cells; Gene Expression Regulation; Glycine; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mice; Pluripotent Stem Cells; Proline; Protein Serine-Threonine Kinases; Signal Transduction; TOR Serine-Threonine Kinases | 2010 |
CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channels; Female; Gene Frequency; Genes, Recessive; Genotype; Humans; Leucine; Male; Membrane Glycoproteins; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Proline; Spain | 2010 |
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.
Topics: Age of Onset; Aged; Alzheimer Disease; Calcium Channels; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Italy; Leucine; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Proline | 2010 |
Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.
Topics: Child, Preschool; Dihydroxyphenylalanine; DNA Mutational Analysis; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Leucine; Metabolic Diseases; Methoxyhydroxyphenylglycol; Mutation; Proline; Tyrosine; Tyrosine 3-Monooxygenase; Young Adult | 2010 |
Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.
Topics: Antiviral Agents; Cyclopropanes; Dipeptides; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance, Viral; Genotype; Hepacivirus; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Kinetics; Leucine; Mutation; Proline; Protease Inhibitors; Recombinant Proteins; Replicon; Sulfones; Urea; Viral Nonstructural Proteins | 2010 |
Folding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways.
Topics: beta-Lactamases; Circular Dichroism; Kinetics; Leucine; Models, Molecular; Proline; Protein Conformation; Protein Folding; Recombinant Proteins; Stereoisomerism; Thermodynamics | 2010 |
Efficient asymmetric organocatalytic formation of erythrose and threose under aqueous conditions.
Topics: Alanine; Catalysis; Leucine; Prebiotics; Proline; Stereoisomerism; Tetroses; Water | 2010 |
Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells.
Topics: Glutamine; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Interleukin-1beta; Interleukin-8; Leucine; Models, Biological; NF-kappa B; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Topics: Animals; Basigin; Brain; Choline O-Acetyltransferase; Cholinergic Agents; Gene Expression Regulation; Interneurons; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proline; tau Proteins; Tauopathies | 2010 |
Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation.
Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Adolescent; Adult; Apoptosis Regulatory Proteins; Child; DNA Mutational Analysis; Family Health; Female; Genotype; Humans; Leucine; Male; Microscopy, Electron, Scanning; Muscular Diseases; Mutation; Phenotype; Proline; Sural Nerve; Young Adult | 2010 |
Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Hepacivirus; Humans; Leucine; Male; Microsomes, Liver; Oligopeptides; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Replicon; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins | 2010 |
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication | 2010 |
Using temperature to optimize resolution and reduce analysis times for bioanalytical diastereomer LC-MS/MS separations.
Topics: Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclopropanes; Dipeptides; Humans; Leucine; Proline; Reproducibility of Results; Stereoisomerism; Sulfones; Tandem Mass Spectrometry; Temperature; Time Factors; Urea | 2011 |
Propensities of aromatic amino acids versus leucine and proline to induce residual structure in the denatured-state ensemble of iso-1-cytochrome c.
Topics: Amino Acid Substitution; Amino Acids, Aromatic; Cytochromes c; Kinetics; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Stability; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Static Electricity; Thermodynamics | 2010 |
Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors.
Topics: Antiviral Agents; Cell Line, Tumor; Cyclopropanes; Hepacivirus; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Molecular Structure; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Sulfonamides | 2010 |
Identification of metastable states in peptide's dynamics.
Topics: Alanine; Leucine; Markov Chains; Molecular Dynamics Simulation; Oligopeptides; Proline; Protein Conformation; Valine | 2010 |
Manganese superoxide dismutase dimorphism relationship with severity and prognosis in cardiogenic shock due to dilated cardiomyopathy.
Topics: Alanine; Alleles; Biomarkers; Cardiomyopathy, Dilated; Cohort Studies; Female; Genetic Association Studies; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Middle Aged; Natriuretic Peptide, Brain; Oxidative Stress; Polymorphism, Genetic; Prognosis; Proline; Reactive Oxygen Species; Severity of Illness Index; Shock, Cardiogenic; Superoxide Dismutase; Valine | 2011 |
Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
Topics: Animals; Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Pan troglodytes; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Tubercidin; Viral Load; Viral Nonstructural Proteins | 2011 |
Pro198Leu polymorphism of GPx-1 gene and activity of erythrocytic glutathione peroxidase and lipid peroxidation products.
Topics: Base Sequence; DNA Primers; Erythrocytes; Glutathione Peroxidase; Humans; Leucine; Lipid Peroxidation; Male; Polymorphism, Genetic; Proline | 2010 |
Lower limb areflexia without central and peripheral conduction abnormalities is highly suggestive of Gerstmann-Sträussler-Scheinker disease Pro102Leu.
Topics: Adult; Brain; Electroencephalography; Electrophysiological Phenomena; Evoked Potentials, Motor; Evoked Potentials, Somatosensory; Family; Female; Gerstmann-Straussler-Scheinker Disease; Humans; Italy; Leucine; Lower Extremity; Magnetic Resonance Imaging; Male; Middle Aged; Neural Conduction; Neurologic Examination; Prions; Proline; Reflex, Abnormal | 2011 |
Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations.
Topics: Adolescent; Anodontia; Arginine; Child; Child, Preschool; Cleft Lip; Cleft Palate; Cohort Studies; Conserved Sequence; DNA-Binding Proteins; Exons; Female; Genetic Variation; Glutamine; Humans; Labial Frenum; Leucine; Male; Mutation, Missense; Phenotype; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Serine; T-Box Domain Proteins; Tongue Diseases; Transcription, Genetic; Tryptophan; Tyrosine | 2011 |
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
Topics: Aminoisobutyric Acids; Carrier Proteins; Catalytic Domain; Clinical Trials, Phase I as Topic; Crystallography, X-Ray; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Proline; Protease Inhibitors; Protein Binding; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2011 |
Amino acid-induced gene expression profiling in clonal β-cell line INS-1E cells.
Topics: Animals; Biomarkers; Cells, Cultured; Gene Expression Profiling; Homocysteine; Insulin-Secreting Cells; Leucine; Oligonucleotide Array Sequence Analysis; Proline; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
TGF-β1 gene polymorphism in renal transplant patients with and without gingival overgrowth.
Topics: Adenine; Adolescent; Adult; Aged; Arginine; Case-Control Studies; Codon; Cyclosporine; Cytosine; Female; Gene Frequency; Genotype; Gingival Overgrowth; Guanine; Haplotypes; Humans; Immunosuppressive Agents; Kidney Transplantation; Leucine; Male; Middle Aged; Polymorphism, Single Nucleotide; Proline; Promoter Regions, Genetic; Thymine; Transforming Growth Factor beta1; Young Adult | 2011 |
CLRN1 mutations cause nonsyndromic retinitis pigmentosa.
Topics: Adult; Audiometry, Pure-Tone; Consanguinity; DNA; Electroretinography; Fundus Oculi; Genes, Recessive; Genetic Linkage; Humans; Intracellular Space; Leucine; Membrane Proteins; Microarray Analysis; Mutation, Missense; Night Blindness; Polymorphism, Single Nucleotide; Proline; Retinitis Pigmentosa; Tissue Distribution; Tryptophan; Young Adult | 2011 |
Metabolism of select amino acids in bacteria from the pig small intestine.
Topics: Animals; Arginine; Bacteria; Digestion; Humans; Intestine, Small; Leucine; Lysine; Methionine; Proline; Swine; Threonine | 2012 |
Proteomic and metabolomic analysis of H2O2-induced premature senescent human mesenchymal stem cells.
Topics: Annexin A2; Cell Proliferation; Cells, Cultured; Cellular Senescence; Choline; Dose-Response Relationship, Drug; Glycine; Humans; Hydrogen Peroxide; Leucine; Mesenchymal Stem Cells; Metabolomics; Proline; Proteomics; Reactive Oxygen Species | 2011 |
Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.
Topics: Age Factors; Animals; Calcium-Binding Proteins; Female; Gene Expression Regulation; Genotype; Hippocampus; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Proline; Secretagogins; tau Proteins | 2011 |
Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cyclopropanes; Dipeptides; Humans; Leucine; Lysophosphatidylcholines; Phosphatidylcholines; Proline; Stereoisomerism; Sulfones; Tandem Mass Spectrometry; Technology, Pharmaceutical; Temperature; Urea | 2011 |
Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization.
Topics: Animals; Calcium-Binding Proteins; Catalysis; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Isomerism; Leucine; Mice; Molecular Sequence Data; Mutation; Peptidylprolyl Isomerase; Proline; Protein Conformation; Substrate Specificity; Tacrolimus Binding Proteins | 2011 |
Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulations.
Topics: Binding Sites; Chemistry, Physical; Computer Simulation; Humans; Leucine; Models, Molecular; Peptide Fragments; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proto-Oncogene Proteins c-mdm2; Serine; Solvents; Spectrum Analysis, Raman; Tumor Suppressor Protein p53 | 2011 |
Precision and accuracy in the quantitative analysis of biological samples by accelerator mass spectrometry: application in microdose absolute bioavailability studies.
Topics: Administration, Oral; Adult; Antiviral Agents; Calibration; Chromatography, Liquid; Cyclopropanes; Dipeptides; Humans; Injections, Intravenous; Leucine; Male; Middle Aged; Proline; Reproducibility of Results; Sensitivity and Specificity; Sulfones; Tandem Mass Spectrometry; Urea; Young Adult | 2011 |
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
Topics: Animals; Animals, Genetically Modified; Cell Count; Cytoskeletal Proteins; Disease Models, Animal; Doxycycline; Environment; Gene Expression Regulation; Hippocampus; Indoles; Leucine; Mice; Mutation; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Proline; RNA, Messenger; tau Proteins; Tauopathies | 2011 |
Functional characterization of the P1059L mutation in the inositol 1,4,5-trisphosphate receptor type 1 identified in a Japanese SCA15 family.
Topics: Amino Acid Substitution; Asian People; Calcium; Cell Line; Humans; Inositol 1,4,5-Trisphosphate Receptors; Leucine; Pedigree; Proline; Protein Isoforms; Spinocerebellar Ataxias | 2011 |
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Molecular Sequence Data; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins | 2011 |
Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Topics: Age Factors; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Brain Chemistry; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leucine; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Presenilin-1; Proline; Protein Carbonylation; Protein Structure, Tertiary; Proteomics | 2011 |
Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.
Topics: Catalysis; Chemistry Techniques, Synthetic; Cyclization; Cyclopropanes; Hydrogenation; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Palladium; Proline; Sulfonamides | 2011 |
Report of two Chinese patients suffering from CLCN7-related osteopetrosis and root dysplasia.
Topics: Adult; Arginine; Bone Density; China; Chloride Channels; Dentofacial Deformities; Genes, Recessive; Genetic Variation; Heterozygote; Homozygote; Humans; Leucine; Male; Osteomyelitis; Osteopetrosis; Osteosclerosis; Phenotype; Point Mutation; Proline; Tooth Abnormalities; Tooth Root; Tooth, Unerupted; Tryptophan | 2012 |
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.
Topics: Absorption; Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Caco-2 Cells; Dogs; Drug Evaluation, Preclinical; Hepacivirus; Humans; Leucine; Macaca mulatta; Male; Microsomes, Liver; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution; Viral Nonstructural Proteins | 2012 |
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Crystallography, X-Ray; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Interferon-alpha; Kinetics; Leucine; Mutagenesis, Site-Directed; Mutation Rate; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Replicon; Thiazoles; Viral Nonstructural Proteins | 2012 |
Interferon-free treatment regimens for hepatitis C: are we there yet?
Topics: Aminoisobutyric Acids; Antiviral Agents; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Oligopeptides; Proline; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; Thiazoles | 2011 |
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Disease Models, Animal; Grape Seed Extract; Humans; Leucine; Male; Mice; Mice, Transgenic; Molecular Weight; Mutation; Polyphenols; Proline; Psychomotor Performance; Spinal Cord; tau Proteins; Tauopathies | 2012 |
Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice.
Topics: Age Factors; Animals; Bacterial Proteins; Brain; Cells, Cultured; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Female; Humans; Leucine; Luminescent Proteins; Male; Mice; Mice, Transgenic; Neurons; Phosphorylation; Proline; Synaptosomes; tau Proteins | 2011 |
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leucine; Male; Mutation; Neuroblastoma; Okadaic Acid; Pentylenetetrazole; Phosphorylation; Proline; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Selenic Acid; Selenium Compounds; tau Proteins; Time Factors; Transfection | 2012 |
[Determination of amino acid contents in cottonseeds using near infrared reflectance spectroscopy].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Calibration; Cottonseed Oil; Cystine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Spectroscopy, Near-Infrared; Threonine; Tyrosine; Valine | 2011 |
Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses.
Topics: Antiviral Agents; Carrier Proteins; Cyclopropanes; Dipeptides; Drug Design; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Models, Molecular; Proline; Quantitative Structure-Activity Relationship; Sulfones; Urea; Viral Nonstructural Proteins | 2012 |
High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Case-Control Studies; Coronary Artery Disease; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetics, Population; Humans; Iran; Leucine; Male; Middle Aged; Neuropeptide Y; Polymorphism, Single Nucleotide; Prevalence; Proline; Young Adult | 2012 |
Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.
Topics: Catalysis; Cyclization; Cyclopropanes; Hepacivirus; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Molecular Structure; Proline; Protease Inhibitors; Ruthenium; Sulfonamides | 2012 |
Enantiopure synthesis of side chain-modified α-amino acids and 5-cis-alkylprolines.
Topics: Amino Acids; Aminolevulinic Acid; Leucine; Molecular Structure; Norleucine; Proline; Stereoisomerism | 2012 |
Glutathione peroxidase 1 Pro198Leu polymorphism in Brazilian Alzheimer's disease patients: relations to the enzyme activity and to selenium status.
Topics: Aged; Alzheimer Disease; Base Sequence; Brazil; Case-Control Studies; DNA Primers; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Selenium | 2012 |
Genetic association between obstructive bronchitis and enzymes of oxidative stress.
Topics: Adult; Arginine; Aryldialkylphosphatase; Bronchitis; Catechol O-Methyltransferase; Chi-Square Distribution; Child; Cohort Studies; Epoxide Hydrolases; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Germany; Histidine; Humans; Leucine; Lung Diseases, Obstructive; Male; Methionine; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Proline; Prospective Studies; Risk Factors; Serine; Smoking; Valine | 2012 |
Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.
Topics: Asian People; Cell Line; Exons; Humans; Jurkat Cells; Leucine; Phosphorylation; Polymorphism, Genetic; Proline; Receptors, IgG; Signal Transduction; Tyrosine | 2012 |
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Topics: Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins | 2012 |
The phosphoproteome of the adenovirus type 2 virion.
Topics: Adenoviridae; Amino Acid Sequence; Chromatography, Liquid; HeLa Cells; Humans; Leucine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proline; Proteome; Proteomics; Viral Proteins; Virion | 2012 |
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Topics: Animals; Brain; CD59 Antigens; Disease Models, Animal; Green Fluorescent Proteins; Humans; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Phosphorylation; Proline; Receptors, Complement; Signal Transduction; tau Proteins; Tauopathies | 2012 |
Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification.
Topics: Adult; Aged; Amino Acid Substitution; Arginine; Basal Ganglia Diseases; Calcinosis; Child; Databases, Genetic; Exome; Female; Humans; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neurologic Examination; Parkinson Disease; Pedigree; Polymerase Chain Reaction; Proline; Receptor, Platelet-Derived Growth Factor beta; Tomography, X-Ray Computed; Tryptophan | 2013 |
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; B-Lymphocytes; Base Sequence; Case-Control Studies; Cell Transformation, Neoplastic; DNA Mutational Analysis; Humans; Immunoglobulin M; Leucine; Lymphoproliferative Disorders; Male; Middle Aged; Molecular Sequence Data; Monoclonal Gammopathy of Undetermined Significance; Myeloid Differentiation Factor 88; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Waldenstrom Macroglobulinemia | 2013 |
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Case-Control Studies; Female; Humans; Immunoglobulin M; Leucine; Lymphoma; Lymphoproliferative Disorders; Male; Middle Aged; Monoclonal Gammopathy of Undetermined Significance; Mutation, Missense; Myeloid Differentiation Factor 88; Prevalence; Proline; Waldenstrom Macroglobulinemia | 2013 |
PlA(1)/PlA(2) polymorphism does not influence response to Gp IIb-IIIa inhibitors in patients undergoing coronary angioplasty.
Topics: Abciximab; Aged; Amino Acid Substitution; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Blood Platelets; Drug Administration Schedule; Eptifibatide; Female; Humans; Immunoglobulin Fab Fragments; Leucine; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Proline; Tirofiban; Treatment Outcome; Tyrosine | 2013 |
The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation.
Topics: Animals; Brain Mapping; Fluorescent Dyes; Imaging, Three-Dimensional; Leucine; Macaca fascicularis; Macaca nemestrina; Male; Neural Pathways; Prefrontal Cortex; Proline; Subthalamic Nucleus; Tritium | 2013 |
Application of capillary electrophoresis coupling with electrochemiluminescence detection to estimate activity of leucine aminopeptidas.
Topics: Case-Control Studies; Cholestasis; Electrophoresis, Capillary; Enzyme Stability; Female; Hepatitis; Humans; Hydrogen-Ion Concentration; Leucine; Leucyl Aminopeptidase; Limit of Detection; Liver Neoplasms; Luminescent Measurements; Male; Proline; Reproducibility of Results; Signal-To-Noise Ratio | 2013 |
The presenilin 1 P264L mutation presenting as non-fluent/agrammatic primary progressive aphasia.
Topics: Female; Fluorodeoxyglucose F18; Hippocampus; Humans; Leucine; Magnetic Resonance Imaging; Middle Aged; Mutation; Positron-Emission Tomography; Presenilin-1; Primary Progressive Nonfluent Aphasia; Proline | 2013 |
Quantitative analysis of interdental Gingiva in patients with chronic periodontitis and transforming growth factor-β1 29C/T gene polymorphisms.
Topics: Adult; Alleles; Azo Compounds; Case-Control Studies; Chronic Periodontitis; Collagen; Coloring Agents; Connective Tissue; Cytosine; Disease Progression; Eosine Yellowish-(YS); Epithelium; Extracellular Matrix; Female; Genotype; Gingiva; Humans; Leucine; Male; Methyl Green; Microvessels; Middle Aged; Polymorphism, Genetic; Proline; Thymine; Transforming Growth Factor beta1 | 2014 |
Deracemization of amino acids by partial sublimation and via homochiral self-organization.
Topics: Alanine; Amino Acids; Leucine; Proline; Stereoisomerism; Valine | 2013 |
Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders.
Topics: Adult; Alanine; Alleles; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Genotype; Glutathione Peroxidase; Humans; Leucine; Male; Middle Aged; Polymorphism, Genetic; Proline; Real-Time Polymerase Chain Reaction; Superoxide Dismutase; Valine | 2013 |
Computational study on the drug resistance mechanism against HCV NS3/4A protease inhibitors vaniprevir and MK-5172 by the combination use of molecular dynamics simulation, residue interaction network, and substrate envelope analysis.
Topics: Amides; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Protease Inhibitors; Protein Conformation; Quinoxalines; Sulfonamides; Thermodynamics; Viral Nonstructural Proteins | 2014 |
Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry.
Topics: Binding Sites; Deuterium Exchange Measurement; Fibrin; Fibrinogen; Humans; Leucine; Mass Spectrometry; Models, Molecular; Peptide Fragments; Proline; Protein Conformation; Protein Folding | 2013 |
Type II antithrombin deficiency caused by a founder mutation Pro73Leu in the Finnish population: clinical picture.
Topics: Adult; Aged; Aged, 80 and over; Antithrombins; Base Sequence; Cohort Studies; DNA Primers; Female; Finland; Founder Effect; Humans; Leucine; Male; Middle Aged; Mutation; Proline; Young Adult | 2013 |
Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of L-prolyl-L-leucyl-glycinamide (PLG) modified in the L-proline or L-proline and L-leucine scaffolds.
Topics: Allosteric Regulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Leucine; Models, Molecular; Molecular Conformation; Oligopeptides; Proline; Receptors, Dopamine D2; Structure-Activity Relationship | 2013 |
Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.
Topics: Analysis of Variance; Animals; Antibodies; Brain; Disease Models, Animal; Gene Expression Regulation; Humans; Leucine; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Molecular Weight; Mutation; Oligodendroglia; Proline; Rats; tau Proteins; Tauopathies | 2014 |
Function of the head-tail junction in the activity of myosin II.
Topics: Actins; Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; Chickens; Conserved Sequence; Leucine; Mutation; Proline; Smooth Muscle Myosins | 2013 |
Baseline hepatitis C virus (HCV) NS3 polymorphisms and their impact on treatment response in clinical studies of the HCV NS3 protease inhibitor faldaprevir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2014 |
Phenotypic expression of the p.Leu1077Pro CFTR mutation in Sicilian cystic fibrosis patients.
Topics: Child; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Gene Expression Regulation; Genotype; Heterozygote; Humans; Leucine; Male; Mutation; Phenotype; Proline; Pseudomonas aeruginosa; Pseudomonas Infections; Sicily; Young Adult | 2013 |
Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.
Topics: Aminoisobutyric Acids; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Drug Stability; Drug Storage; Feces; Female; Hepatocytes; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Leucine; Male; Metabolic Clearance Rate; Microsomes; Oligopeptides; Proline; Protein Binding; Quinolines; Thiazoles | 2014 |
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.
Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Stability; Female; Fibroblasts; Glucuronides; Hepatocytes; Humans; Kinetics; Leucine; Liver; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Organic Anion Transporters; Proline; Quinolines; Sodium; Thiazoles | 2014 |
Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Bile; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Dose-Response Relationship, Drug; Drug Stability; Fibroblasts; Glucuronides; Hepacivirus; Hepatocytes; Leucine; Liver; Male; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Proline; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles | 2014 |
Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries.
Topics: Aminoisobutyric Acids; Anti-HIV Agents; Antiviral Agents; Carbamates; Developing Countries; Drug Industry; Drug Therapy, Combination; Health Services Accessibility; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine | 2014 |
IgG-lymphoplasmacytic lymphoma following polycythemia vera: JAK2 V617F and MYD88 L265P mutations separated in the same house.
Topics: Aged; Amino Acid Substitution; Humans; Immunoglobulin G; Janus Kinase 2; Leucine; Male; Mutation, Missense; Myeloid Differentiation Factor 88; Phenylalanine; Polycythemia Vera; Proline; Valine; Waldenstrom Macroglobulinemia | 2014 |
Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up.
Topics: Aged; Amino Acids; Arginine; Betaine; Body Mass Index; Fasting; Female; Humans; Hypertriglyceridemia; Isoleucine; Leucine; Male; Middle Aged; Odds Ratio; Phenylalanine; Proline; Risk Factors; ROC Curve; Triglycerides; Valine | 2014 |
Platelet glycoprotein IIIa gene polymorphism (Leu33Pro) and aspirin resistance in a very elderly Chinese population.
Topics: Aged; Aged, 80 and over; Aspirin; Base Sequence; CD36 Antigens; DNA Primers; Drug Resistance; Female; Humans; Leucine; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline | 2014 |
Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Interferons; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate | 2014 |
Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats.
Topics: Administration, Oral; Aminoisobutyric Acids; Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Injections, Intravenous; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles; Urine | 2014 |
Novel complex disease allele mutations in cleidocranial dysplasia patients.
Topics: Adenine; Alleles; Amino Acid Sequence; Asparagine; Aspartic Acid; Case-Control Studies; Cleidocranial Dysplasia; Conserved Sequence; Core Binding Factor Alpha 1 Subunit; Cytosine; Exons; Female; Guanine; Humans; Leucine; Male; Mutation, Missense; Proline; Protein Conformation; Thymine; Tooth, Supernumerary | 2014 |
A case of successful treatment with telaprevir-based triple therapy for hepatitis C infection after treatment failure with vaniprevir-based triple therapy.
Topics: Aged; Antiviral Agents; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Male; Oligopeptides; Proline; Sulfonamides; Treatment Failure | 2014 |
Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion.
Topics: Abortion, Spontaneous; Adolescent; Adult; Base Sequence; Catalase; DNA Primers; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Polymorphism, Genetic; Proline; Young Adult | 2014 |
Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.
Topics: Ammonium Compounds; Glutamine; Immunoblotting; Leucine; Methionine Sulfoximine; Monomeric GTP-Binding Proteins; Mutation; Nitrogen; Phosphorylation; Proline; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors | 2014 |
A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Botulinum Toxins, Type A; Green Fluorescent Proteins; Humans; In Vitro Techniques; Larva; Leucine; Locomotion; Miniature Postsynaptic Potentials; Muscle, Skeletal; Mutation; Neuromuscular Junction; Patch-Clamp Techniques; Phenotype; Proline; Receptors, Cholinergic; Swimming; Zebrafish | 2014 |
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
Topics: Acoustic Stimulation; Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inhibition, Psychological; Leucine; Mice; Mice, Transgenic; Mutation; Phenotype; Proline; Psychotic Disorders; Reflex, Startle; tau Proteins | 2014 |
Computational study on the molecular mechanisms of drug resistance of Narlaprevir due to V36M, R155K, V36M+R155K, T54A, and A156T mutations of HCV NS3/4A protease.
Topics: Antiviral Agents; Cyclopropanes; Dipeptides; Drug Resistance, Viral; Genes, Viral; Hepacivirus; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Sulfones; Urea; Viral Nonstructural Proteins | 2014 |
Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited.
Topics: Algorithms; Animals; Axonal Transport; Axons; Body Water; Connectome; Contrast Media; Diffusion; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Gadolinium DTPA; Leucine; Macaca mulatta; Male; Models, Neurological; Motor Cortex; Occipital Lobe; Proline; Research Design; ROC Curve; Sensitivity and Specificity; Tritium; White Matter | 2014 |
A novel MYH7 Leu1453pro mutation resulting in Laing distal myopathy in an Irish family.
Topics: Adult; Aged; Brain; Cardiac Myosins; Creatine Kinase; Distal Myopathies; Electromyography; Epilepsy; Family Health; Female; Humans; Ireland; Leucine; Male; Middle Aged; Muscle, Skeletal; Mutation; Myosin Heavy Chains; Proline | 2015 |
One-step molecular detection of the MYD88 L265P mutation by unlabeled probe genotyping analysis.
Topics: Antigens, Differentiation; Genotype; Humans; Leucine; Molecular Diagnostic Techniques; Mutation; Oligonucleotide Probes; Proline; Reproducibility of Results; Sequence Analysis, DNA; Waldenstrom Macroglobulinemia | 2015 |
Influence of the GPX1 gene polymorphism to aerobic capacity and efficiency of glutathione supplementation in athletes.
Topics: Adult; Alleles; Antioxidants; Athletes; Case-Control Studies; Female; Gene Expression; Gene Frequency; Genotype; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heterozygote; Homozygote; Humans; Injections, Intramuscular; Leucine; Male; Oxygen Consumption; Physical Endurance; Polymorphism, Single Nucleotide; Proline | 2014 |
Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient.
Topics: Adult; Amyloid Neuropathies, Familial; Humans; Leucine; Male; Meninges; Mutation; Nigeria; Proline | 2015 |
The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.
Topics: Adult; Amino Acid Substitution; Cells, Cultured; Child; Child, Preschool; Family; Female; HeLa Cells; Homeostasis; Humans; Leucine; Male; Mutation, Missense; Pedigree; Proline; Receptors, Thrombopoietin; Signal Transduction; Thrombocytopenia; Thrombocytosis; Thrombopoietin; Young Adult | 2015 |
Chemiluminescence Detection of Serine, Proline, Glycine, Asparagine, Leucine, and Histidine by Using Corresponding Aminoacyl-tRNA Synthetases as Recognition Elements.
Topics: Amino Acyl-tRNA Synthetases; Asparagine; Biological Assay; Buffers; Glycine; Histidine; Humans; Leucine; Luminescence; Luminescent Measurements; Luminol; Proline; Sensitivity and Specificity; Serine; Solutions; Water | 2015 |
Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia.
Topics: Alkaline Phosphatase; Animals; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetulus; Humans; Hypophosphatasia; Leucine; Mutation; Phenotype; Proline; Tooth Demineralization | 2015 |
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cohort Studies; Female; Hepatitis C, Chronic; HIV Infections; Humans; Leucine; Male; Middle Aged; Oligopeptides; Patient Acceptance of Health Care; Proline; Prospective Studies; Protease Inhibitors; Quinolines; RNA, Viral; Switzerland; Thiazoles; Viral Load | 2015 |
Probable novel PSEN2 Pro123Leu mutation in a Chinese Han family of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Substitution; Asian People; Codon; Diagnostic Imaging; Exons; Genetic Association Studies; Humans; Leucine; Mutation, Missense; Presenilin-2; Proline | 2015 |
Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.
Topics: Animals; Antiviral Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Gene Expression Profiling; Hepacivirus; Hepatitis C; Hepatocytes; High-Throughput Nucleotide Sequencing; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mice; Mice, Transgenic; Mutation, Missense; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Virus Replication | 2016 |
The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum.
Topics: 3T3 Cells; Amino Acid Motifs; Animals; Dentin; Endoplasmic Reticulum; Extracellular Matrix Proteins; Golgi Apparatus; Humans; Leucine; Mice; Osteoblasts; Proline; Valine | 2016 |
The proline-rich region of glyceraldehyde-3-phosphate dehydrogenase from human sperm may bind SH3 domains, as revealed by a bioinformatic study of low-complexity protein segments.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Cell Adhesion Molecules; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Leucine; Male; Mutation, Missense; Proline; Protein-Tyrosine Kinases; Signal Transduction; Sperm Tail; src Homology Domains | 2016 |
From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.
Topics: Adult; Aged; Antioxidants; Case-Control Studies; Female; Gene Expression Regulation, Leukemic; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Isoleucine; Leucine; Leukemia, Myeloid, Acute; Male; Middle Aged; Multivariate Analysis; Mutation; Polymorphism, Genetic; Proline; Reactive Oxygen Species; Risk; Romania; Superoxide Dismutase; Valine | 2016 |
[Vaniprevir with pegylated interferon and ribavirin in treatment for chronic hepatitis C].
Topics: Clinical Trials as Topic; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Hepatitis C, Chronic; Humans; Indoles; Interferons; Isoindoles; Lactams, Macrocyclic; Leucine; Proline; Ribavirin; Sulfonamides | 2015 |
Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their differential responses to cortisol and aldosterone.
Topics: Aldosterone; Amino Acid Substitution; Binding Sites; Conserved Sequence; Dexamethasone; Glutamine; HEK293 Cells; Humans; Hydrocortisone; Hydrogen Bonding; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Proline; Protein Binding; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Serine; Structural Homology, Protein; Transcriptional Activation | 2016 |
Association Between the Transforming Growth Factor Beta 1 Gene Polymorphisms and Turkish Patients with Nonsyndromic Cleft Lip With/Without Cleft Palate.
Topics: Amino Acid Substitution; Arginine; Case-Control Studies; Child; Child, Preschool; Cleft Lip; Cleft Palate; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Leucine; Polymorphism, Single Nucleotide; Proline; Transforming Growth Factor beta1; Turkey | 2016 |
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Topics: Aged; Amino Acid Substitution; Animals; Cholesterol, HDL; Coronary Disease; DNA Mutational Analysis; Female; Genetic Variation; Heterozygote; Homozygote; Humans; Leucine; Male; Mice; Middle Aged; Proline; Protein Processing, Post-Translational; Risk; Scavenger Receptors, Class B | 2016 |
Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.
Topics: Adenine; Amino Acid Substitution; Female; Humans; Immunoglobulin G; Leucine; Mutation, Missense; Myeloid Differentiation Factor 88; Piperidines; Proline; Pyrazoles; Pyrimidines; Treatment Outcome; Waldenstrom Macroglobulinemia | 2016 |
Functional analysis of the p.(Leu15Pro) and p.(Gly20Arg) sequence changes in the signal sequence of LDL receptor.
Topics: Animals; Arginine; CHO Cells; Cricetinae; Cricetulus; Endoplasmic Reticulum; Glycine; Heterozygote; Humans; Hyperlipoproteinemia Type II; Leucine; Microscopy, Confocal; Mutation; Pedigree; Proline; Protein Folding; Protein Sorting Signals; Protein Structure, Secondary; Receptors, LDL | 2016 |
Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report.
Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; Biological Transport; Chlorocebus aethiops; CHO Cells; Cholesterol; Cholesterol, HDL; COS Cells; Cricetulus; Endosomes; Genotype; HEK293 Cells; Humans; Leucine; Liver X Receptors; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Primary Cell Culture; Proline; Sterol Regulatory Element Binding Protein 2; Transfection | 2016 |
Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy.
Topics: Aminoisobutyric Acids; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Polymers; Proline; Quinolines; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2016 |
Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease.
Topics: Charcot-Marie-Tooth Disease; Connexins; DNA Mutational Analysis; Gap Junction beta-1 Protein; Green Fluorescent Proteins; HeLa Cells; Humans; Leucine; Male; Mutation, Missense; Proline; Protein Transport; Schwann Cells; Transfection | 2016 |
Leucine-Enriched Essential Amino Acids Augment Mixed Protein Synthesis, But Not Collagen Protein Synthesis, in Rat Skeletal Muscle after Downhill Running.
Topics: Amino Acids, Essential; Animals; Collagen; Female; Hydroxyproline; Leucine; Muscle Proteins; Muscle, Skeletal; Physical Conditioning, Animal; Proline; Protein Biosynthesis; Rats; Rats, Wistar; Running | 2016 |
Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir.
Topics: Acrylates; Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins | 2016 |
Genetic analysis of CHCHD2 gene in Chinese Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Asian People; China; DNA-Binding Proteins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Leucine; Male; Middle Aged; Mitochondrial Proteins; Mutation; Parkinson Disease; Proline; Risk Factors; Transcription Factors | 2016 |
Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Binding Sites; Catalytic Domain; Codon; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Humans; Hydrogen Bonding; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Molecular Conformation; Mutation; Oligopeptides; Proline; Protein Binding; Quinolines; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2016 |
Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Brain; Cell Line, Tumor; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose; Humans; Leucine; Membrane Proteins; Mutation; Neuroblastoma; Phosphorylation; Proline; RNA, Messenger; RNA, Small Interfering; Selenoproteins; tau Proteins; Transfection | 2017 |
Association between GPX1 Pro189Leu polymorphism and the occurrence of bladder cancer in Morocco.
Topics: Adult; Aged; Alleles; Base Sequence; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Middle Aged; Morocco; Polymorphism, Genetic; Proline; Risk Factors; Urinary Bladder Neoplasms | 2016 |
The metabolites in peripheral blood mononuclear cells showed greater differences between patients with impaired fasting glucose or type 2 diabetes and healthy controls than those in plasma.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Fasting; Female; Glucose Metabolism Disorders; Humans; Inflammation Mediators; Leucine; Leukocytes, Mononuclear; Lysophosphatidylcholines; Male; Metabolomics; Middle Aged; Proline; Valine | 2017 |
Discrepant platelet and plasma von Willebrand factor in von Willebrand disease patients with p.Pro2808Leufs*24.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Platelets; Canada; Cells, Cultured; Endothelial Cells; Female; Genetic Variation; Hemorrhage; Heterozygote; Homozygote; Humans; Leucine; Male; Microscopy, Fluorescence; Middle Aged; Pedigree; Phenotype; Plasma; Proline; von Willebrand Disease, Type 3; von Willebrand Factor; Young Adult | 2017 |
Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia.
Topics: Adult; Alzheimer Disease; Asian People; Atrophy; Codon; Dementia; Exons; Genetic Association Studies; Genetic Predisposition to Disease; Helix-Loop-Helix Motifs; Humans; Leucine; Magnetic Resonance Imaging; Mutation, Missense; Neuroimaging; Parietal Lobe; Presenilin-1; Proline | 2017 |
Kohamamides A, B, and C, Cyclic Depsipeptides from an Okeania sp. Marine Cyanobacterium.
Topics: Cyanobacteria; Depsipeptides; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leucine; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Proline; Structure-Activity Relationship | 2017 |
Phase Separation Macrocyclization in a Complex Pharmaceutical Setting: Application toward the Synthesis of Vaniprevir.
Topics: Alkynes; Cyclization; Cyclopropanes; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Macromolecular Substances; Microwaves; Molecular Structure; Proline; Sulfonamides | 2017 |
Formulation, Characterization and Stability Assessment of a Food-Derived Tripeptide, Leucine-Lysine-Proline Loaded Chitosan Nanoparticles.
Topics: Cell Line; Cell Survival; Chitosan; Gels; Humans; Leucine; Lysine; Nanoparticles; Particle Size; Peptides; Polyphosphates; Proline | 2017 |
Pharmacokinetics, Safety, and Tolerability of Glecaprevir and Pibrentasvir in Healthy White, Chinese, and Japanese Adult Subjects.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Asian People; Benzimidazoles; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Half-Life; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; White People | 2017 |
The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice.
Topics: Age Factors; alpha-Synuclein; Animals; beta-N-Acetylhexosaminidases; Brain; Dopamine; Glucosylceramidase; Humans; Leucine; Mice; Mice, Transgenic; Mutation; Neurons; Proline; Psychomotor Performance; Smell; Substantia Nigra; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2017 |
Mavyret and Vosevi--two new combinations for chronic HCV infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome | 2017 |
[Molecular recognition mechanism and motion of HCV NS3/4A protease with Faldaprevir analogue].
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Endopeptidases; Hepacivirus; Intracellular Signaling Peptides and Proteins; Leucine; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Serine Proteases; Thiazoles; Viral Nonstructural Proteins | 2016 |
ALS-Related Mutant FUS Protein Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers.
Topics: Amyotrophic Lateral Sclerosis; Cell Nucleus; Cells, Cultured; Cytoplasmic Granules; Female; Fibroblasts; Follow-Up Studies; Humans; Leucine; Male; Mutation; Neural Conduction; Proline; Protein Transport; RNA-Binding Protein FUS; Skin; Subcellular Fractions; Time Factors; Tubulin | 2017 |
Benefit-risk assessment for sofosbuvir/velpatasvir/voxilaprevir based on patient population and hepatitis C virus genotype: U. S. Food and Drug Administration's evaluation.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Risk Assessment; Sofosbuvir; Sulfonamides; Sustained Virologic Response; United States; United States Food and Drug Administration; Viral Nonstructural Proteins | 2018 |
New Oral HCV Drug.
Topics: Administration, Oral; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Contraindications, Drug; Cyclopropanes; Drug Approval; Drug Combinations; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2017 |
Patient-Reported Outcomes Following Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir and Velpatasvir, With or Without Voxilaprevir.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Middle Aged; Patient Reported Outcome Measures; Placebos; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Surveys and Questionnaires; Sustained Virologic Response | 2018 |
Proton-pump inhibitors and glecaprevir plus pibrentasvir in HCV infection.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Proton Pump Inhibitors; Protons; Pyrrolidines; Quinoxalines; Sulfonamides | 2017 |
Proton-pump inhibitors and glecaprevir plus pibrentasvir in HCV infection - Authors' reply.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Proton Pump Inhibitors; Protons; Pyrrolidines; Quinoxalines; Sulfonamides | 2017 |
Sofosbuvir and velpatasvir with or without voxilaprevir in direct-acting antiviral-naïve chronic hepatitis C: patient-reported outcomes from POLARIS 2 and 3.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Macrocyclic Compounds; Male; Middle Aged; Multicenter Studies as Topic; Patient Reported Outcome Measures; Proline; Quinoxalines; Randomized Controlled Trials as Topic; Self Report; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2018 |
Biochemical Basis of Vosevi, a New Treatment for Hepatitis C
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Hepacivirus; Hepatitis; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Serine Proteases; Sofosbuvir; Sulfonamides; Viral Nonstructural Proteins | 2018 |
Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C Infection
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Serine Proteases; Sulfonamides; Viral Nonstructural Proteins | 2018 |
New Drugs 2018, part 1.
Topics: Aminoisobutyric Acids; Antibodies, Monoclonal; Antibodies, Neutralizing; Antipyrine; Benzamides; Benzimidazoles; Broadly Neutralizing Antibodies; Carbamates; Cyclopropanes; Drug Approval; Drug Combinations; Edaravone; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Naltrexone; Natriuretic Peptides; Proline; Pyridines; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; United States; United States Food and Drug Administration | 2018 |
Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Autophagy; Cardiomyopathy, Restrictive; Child; Heart; Heart Transplantation; Humans; Leucine; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Muscle, Skeletal; Mutation; Myocardium; Myofibrils; Proline | 2018 |
Editorial: direct-acting antivirals significantly improve quality of life in patients with hepatitis C virus infection-Author's reply.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Patient Reported Outcome Measures; Proline; Quality of Life; Quinoxalines; Sofosbuvir; Sulfonamides | 2018 |
Editorial: direct-acting antivirals significantly improve quality of life in patients with hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Patient Reported Outcome Measures; Proline; Quality of Life; Quinoxalines; Sofosbuvir; Sulfonamides | 2018 |
Beyond one virus: vaccination against hepatitis B after hepatitis C treatment.
Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Expeditions; Genotype; Hepatitis B; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Vaccination | 2018 |
Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets.
Topics: Administration, Intranasal; Animals; Callithrix; Female; Leucine; Male; Oxytocin; Pair Bond; Proline; Sexual Behavior, Animal; Social Behavior; Social Isolation | 2018 |
New Treatment Options for Hepatitis C Virus Infection in End-Stage Kidney Disease: To Treat or Not to Treat.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2018 |
Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Gene Deletion; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Mice, SCID; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Failure; Viral Nonstructural Proteins | 2018 |
Sofosbuvir + velpatasvir + voxilaprevir for the treatment of hepatitis C infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2018 |
P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.
Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Drug Resistance; Fatty Liver; Fibric Acids; Hyperlipidemias; Hypolipidemic Agents; Leucine; Mice; Mice, Transgenic; Mutation, Missense; PPAR gamma; Proline | 2018 |
Effects of rearing system on meat quality, fatty acid and amino acid profiles of Hu lambs.
Topics: Alanine; Amino Acids; Animal Feed; Animal Husbandry; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Food Quality; Leucine; Meat; Proline; Sheep; Time Factors; Weight Gain | 2018 |
De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.
Topics: Acetates; Acetyl Coenzyme A; Acetyltransferases; Acyl Coenzyme A; Alcohol Oxidoreductases; Animals; Carbon; Fatty Acids; Gene Expression Regulation; Gene Knockout Techniques; Glucose; Insect Vectors; Leucine; Mevalonic Acid; Proline; Sterols; Threonine; Trypanosoma brucei brucei; Tsetse Flies | 2018 |
Retreatment of hepatitis C virus: can it get any better?
Topics: Aminoisobutyric Acids; Carbamates; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides | 2018 |
Favorable efficacy of glecaprevir plus pibrentasvir as salvage therapy for HCV failures to prior direct-acting antivirals regimens.
Topics: Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Failure; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Salvage Therapy; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2019 |
Hepatitis C virus genetic diversity by geographic region within genotype 1-6 subtypes among patients treated with glecaprevir and pibrentasvir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Genetic Variation; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Phylogeny; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Viral Nonstructural Proteins | 2018 |
Pharmacokinetics and safety of glecaprevir and pibrentasvir in HCV-negative subjects with hepatic impairment.
Topics: Adolescent; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Liver; Liver Diseases; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2019 |
Glecaprevir/Pibrentasvir (Mavyret) for the Treatment of Chronic Hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2018 |
Glecaprevir/Pibrentasvir Induced Cholestatic Jaundice in a HCV Patient with Renal Failure. A Case Presentation.
Topics: Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Jaundice, Obstructive; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency; Sulfonamides | 2019 |
Glecaprevir and Pibrentasvir for Japanese Patients with Human Immunodeficiency Virus and Genotype 3 Hepatitis C Virus Coinfection: A Report of Three Cases.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Coinfection; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2019 |
Direct-acting antivirals for chronic hepatitis C virus genotype 5 and 6 infections.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2019 |
APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Contraindications, Drug; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response | 2019 |
The Successful Retreatment with Glecaprevir and Pibrentasvir of Genotype 1 or 2 HCV-infected Hemodialysis Patients who Failed to Respond to NS5A and Protease Inhibitor Treatment.
Topics: Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Isoquinolines; Lactams, Macrocyclic; Leucine; Middle Aged; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Renal Dialysis; Retreatment; Sulfonamides; Treatment Failure; Valine | 2019 |
UBC9 Mutant Reveals the Impact of Protein Dynamics on Substrate Selectivity and SUMO Chain Linkages.
Topics: Amino Acid Sequence; Amino Acid Substitution; Catalytic Domain; Cysteine; Humans; Leucine; Mutation; Proline; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Small Ubiquitin-Related Modifier Proteins; Substrate Specificity; Sumoylation; Ubiquitin-Conjugating Enzymes | 2019 |
Fibrosing cholestatic hepatitis in a kidney transplant recipient with hepatitis C virus.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Bilirubin; Cholestasis; Cyclopropanes; Fatal Outcome; Hepacivirus; Hepatitis C; Humans; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Transplant Recipients; Viral Load | 2019 |
NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retreatment; Sequence Deletion; Sulfonamides; Sustained Virologic Response; Treatment Failure; Viral Nonstructural Proteins | 2019 |
Public health round-up.
Topics: Adenosine Monophosphate; Alanine; Aminoisobutyric Acids; Anti-Bacterial Agents; Antibodies, Monoclonal; Benzimidazoles; Cyclopropanes; Democratic Republic of the Congo; Disease Outbreaks; Drug Resistance, Bacterial; Global Health; Hemorrhagic Fever, Ebola; Hepatitis C; Humans; Interinstitutional Relations; Lactams, Macrocyclic; Leucine; Malaria; Measles; Measles Vaccine; Poliomyelitis; Proline; Public Health Practice; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Ribonucleotides; Sulfonamides; Tuberculosis | 2019 |
Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes.
Topics: Amino Acid Substitution; Child; Diabetes Mellitus; DNA Mutational Analysis; Exome Sequencing; Hepatocyte Nuclear Factor 3-beta; Humans; Leucine; Male; Models, Molecular; Mutation, Missense; Polymorphism, Single Nucleotide; Proline; Syndrome | 2019 |
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Protease Inhibitors; Quinoxalines; Sulfonamides; Viral Nonstructural Proteins | 2019 |
A Comparison of the Ability of Leu
Topics: Animals; Calcium; CHO Cells; Cricetulus; Humans; Leucine; Membrane Potentials; Oxytocin; Potassium; Potassium Channels, Calcium-Activated; Proline; Receptors, Oxytocin; Signal Transduction; Type C Phospholipases | 2019 |
Renal transplantation from seropositive hepatitis C virus donors to seronegative recipients in Spain: a prospective study.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Donor Selection; Female; Graft Rejection; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Living Donors; Male; Middle Aged; Patient Safety; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Spain; Sulfonamides; Treatment Outcome | 2019 |
HLA-C*07:465, a novel HLA-C*07 variant, detected in a Singaporean Chinese individual.
Topics: Alleles; Asian People; Bone Marrow Transplantation; Codon; Exons; Haplotypes; HLA-C Antigens; Humans; Leucine; Polymorphism, Single Nucleotide; Proline; Sequence Analysis, DNA; Singapore | 2019 |
Safety of Hepatitis C Viral Protease Inhibitors in Compensated Cirrhotics: Lingering Concerns Put to Rest?
Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides | 2019 |
Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic HCV infection and psychiatric disorders: An integrated analysis.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antidepressive Agents; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Mental Disorders; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Adherence and Compliance; Young Adult | 2019 |
Bi-allelic Pro291Leu variant in KCNQ4 leads to early onset non-syndromic hearing loss.
Topics: Age of Onset; Consanguinity; Deafness; Exome Sequencing; Female; Genetic Heterogeneity; Genetic Predisposition to Disease; Humans; KCNQ Potassium Channels; Leucine; Male; Mutation, Missense; Pedigree; Proline | 2019 |
Contemporary HCV pangenotypic DAA treatment protocols are exclusionary to real world HIV-HCV co-infected patients.
Topics: Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Benzimidazoles; Carbamates; Coinfection; Cyclopropanes; Drug Interactions; Female; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 4 or More Rings; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome; Viral Load | 2019 |
Sofosbuvir/Velpatasvir/Voxilaprevir for Previous Treatment Failures With Glecaprevir/Pibrentasvir in Chronic Hepatitis C Infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Male; Proline; Pyrrolidines; Quinoxalines; RNA, Viral; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome | 2019 |
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Dose-Response Relationship, Drug; Drug Combinations; Drug Discovery; Hepacivirus; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Microbial Sensitivity Tests; Molecular Structure; Proline; Protease Inhibitors; Quinoxalines; Sofosbuvir; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins | 2019 |
Effects of Pro1266Leu mutation on structure and function of glycoprotein Ib binding domain of von Willebrand factor.
Topics: Leucine; Models, Molecular; Molecular Dynamics Simulation; Mutation; Platelet Glycoprotein GPIb-IX Complex; Principal Component Analysis; Proline; Protein Binding; Protein Domains; Protein Interaction Maps; Protein Structure, Secondary; Structure-Activity Relationship; von Willebrand Factor | 2019 |
Real-life glecaprevir/pibrentasvir in a large cohort of patients with hepatitis C virus infection: The MISTRAL study.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Italy; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Longitudinal Studies; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Substance Abuse, Intravenous; Sulfonamides; Sustained Virologic Response; Young Adult | 2019 |
Role of NS5A-L31/Y93 Double Wild-type in Failure of Glecaprevir/Pibrentasvir Double Therapy in Two Patients with a History of Direct-acting Antiviral Agent Failure: An Ultra-deep Sequencing Analysis.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Genotype; Hepatitis C, Chronic; Humans; Interferons; Lactams, Macrocyclic; Leucine; Polymorphism, Genetic; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2019 |
A Cost-Effectiveness Analysis of Shortened Direct-Acting Antiviral Treatment in Genotype 1 Noncirrhotic Treatment-Naive Patients With Chronic Hepatitis C Virus.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cost-Benefit Analysis; Cyclopropanes; Decision Trees; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Markov Chains; Proline; Quinoxalines; Sofosbuvir; State Medicine; Sulfonamides; United Kingdom | 2019 |
Evaluation of 8-week glecaprevir/pibrentasvir treatment in direct-acting antiviral-naïve noncirrhotic HCV genotype 1 and 2infected patients in a real-world setting in Japan.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sequence Analysis, DNA; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome; Young Adult | 2019 |
Real-world effectiveness and safety of glecaprevir/pibrentasvir in Asian patients with chronic hepatitis C.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Sustained Virologic Response; Taiwan | 2019 |
Successful prolonged treatment of glecaprevir/pibrentasvir for chronic hepatitis C patient with treatment failure after 8-week therapy: a case report.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Genome, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Proline; Pyrrolidines; Quinoxalines; Recurrence; RNA, Viral; Sulfonamides; Sustained Virologic Response; Treatment Failure; Treatment Outcome | 2019 |
Protective effects of di- and tri-peptides containing proline, glycine, and leucine on liver enzymology and histopathology of diabetic mice.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Experimental; Glycine; Leucine; Liver; Mice; Peptides; Proline | 2022 |
Efficacy and Safety of Glecaprevir/pibrentasvir in a Patient With HCV-Induced Porphyria Cutanea Tarda Receiving Vedolizumab for Crohn´s Disease.
Topics: Aminoisobutyric Acids; Antibodies, Monoclonal, Humanized; Benzimidazoles; Crohn Disease; Cyclopropanes; Gastrointestinal Agents; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Porphyria Cutanea Tarda; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Clinical Relevance of the High Prevalence of MYD88 L265P Mutated Vitreoretinal Lymphoma Identified by Droplet Digital Polymerase Chain Reaction.
Topics: Adult; Aged; Female; Humans; Immunohistochemistry; Intraocular Lymphoma; Leucine; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Mutation, Missense; Myeloid Differentiation Factor 88; Polymerase Chain Reaction; Proline; Prospective Studies; Retinal Neoplasms; Vitrectomy; Vitreous Body; Waldenstrom Macroglobulinemia | 2021 |
Retreatment Options for Patients Who Failed Direct-Acting Antiviral Regimens Containing NS5A Inhibitors: Is Glecaprevir/Pibrentasvir a Valid and Robust Option?
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Humans; Infections; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides; Treatment Failure | 2019 |
Efficacy and Safety of 8 Weeks of Glecaprevir/Pibrentasvir in Treatment-Naïve, HCV-Infected Patients with APRI ≤ 1 in a Single-Arm, Open-Label, Multicenter Study.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Comorbidity; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Young Adult | 2019 |
Are all cirrhotic patients equal?
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Expeditions; Genotype; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection: Real-world effectiveness and safety in Taiwan.
Topics: Aminoisobutyric Acids; Antiviral Agents; Asia, Eastern; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Taiwan | 2020 |
A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cost-Benefit Analysis; Cyclopropanes; Drug Therapy, Combination; Female; Fluorenes; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Uridine Monophosphate | 2020 |
Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection.
Topics: Adolescent; Aminoisobutyric Acids; Anilides; Antiviral Agents; Benzimidazoles; Carbamates; Child; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Valine | 2020 |
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir.
Topics: Amides; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Catalytic Domain; Crystallography, X-Ray; Cyclopropanes; Hepacivirus; Lactams, Macrocyclic; Leucine; Mutation; Proline; Protein Binding; Quinoxalines; Serine Proteases; Serine Proteinase Inhibitors; Sulfonamides; Viral Nonstructural Proteins | 2020 |
Hepatitis C and Compensated Cirrhosis Drug Approved for Eight-Week Treatment.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Approval; Drug Combinations; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; United States | 2020 |
Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real-world setting: A large, multicenter study from Japan.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cohort Studies; Cyclopropanes; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Multicenter Studies as Topic; Proline; Propensity Score; Pyrrolidines; Quinoxalines; Severity of Illness Index; Sulfonamides; Time Factors | 2020 |
Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection and severe renal impairment.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Retrospective Studies; Sulfonamides; Sustained Virologic Response; Taiwan | 2020 |
Successful treatment with glecaprevir/pibrentasvir for chronic hepatitis C complicated by primary biliary cholangitis.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis, Biliary; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Editorial: glecaprevir/pibrentasvir for the treatment of hepatitis C virus-do baseline resistance-associated substitutions matter?
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Editorial: glecaprevir/pibrentasvir for the treatment of hepatitis C virus-do baseline resistance-associated substitutions matter? Authors' reply.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Utilization of Amino Acid-Rich Wastes for Microbial Lipid Production.
Topics: Amino Acids; Animals; Basidiomycota; Biofuels; Biomass; Carbohydrates; Fatty Acids; Fishes; Hydrogen-Ion Concentration; Industrial Microbiology; Industrial Waste; Leucine; Lipids; Meat; Proline; Sheep; Tryptophan | 2020 |
Successful ongoing retreatment with glecaprevir/pibrentasvir + sofosbuvir + ribavirin in a patient with HCV genotype 3 who failed glecaprevir/pibrentasvir with both NS3 and NS5A resistance.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Outcome | 2020 |
Efficacy and safety of glecaprevir/pibrentasvir in patients with hepatitis C virus infection aged ≥75 years.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepatitis C; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Treatment Outcome | 2020 |
Effectiveness of 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve, Compensated Cirrhotic Patients with Chronic Hepatitis C Infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Databases, Factual; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome; United States | 2020 |
Real-world effectiveness of glecaprevir/pibrentasvir and ledipasvir/sofosbuvir for mixed genotype hepatitis C infection: A multicenter pooled analysis in Taiwan.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Fluorenes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Taiwan | 2020 |
Renal function in HCV therapy: Just another thing to ignore?
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Successful fourth line treatment of a relapse patient with chronic hepatitis C virus infection genotype 3a using sofosbuvir, glecaprevir/pibrentasvir, and ribavirin: a case report.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Middle Aged; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Outcome | 2020 |
Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Betacoronavirus; Computer Simulation; Cyclopropanes; Drug Evaluation, Preclinical; Lactams, Macrocyclic; Leucine; Maraviroc; Molecular Structure; Proline; Protease Inhibitors; Quinoxalines; SARS-CoV-2; Sulfonamides | 2020 |
Outcomes of the Treatment with Glecaprevir/Pibrentasvir following heart transplantation utilizing hepatitis C viremic donors.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Heart Transplantation; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome; Viremia | 2020 |
Efficacy of sofosbuvir/velpatasvir/voxilaprevir in direct-acting antiviral experienced patients with hepatitis C virus.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response | 2021 |
Sofosbuvir/velpatasvir/voxilaprevir plus ribavirin for chronic hepatitis C patients with direct acting antiviral failures: Implications for viral elimination in Taiwan.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Genotype; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Taiwan | 2020 |
Management and tolerability of glecaprevir-pibrentasvir pharmacotherapy in hepatitis C viremic heart and lung transplant recipients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Lung; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Transplant Recipients; Viremia | 2020 |
Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Resistance, Viral; Genotype; Germany; Hepacivirus; Humans; Italy; Lactams, Macrocyclic; Leucine; Prevalence; Proline; Pyrrolidines; Quinoxalines; Retreatment; Retrospective Studies; Spain; Sulfonamides; Viral Nonstructural Proteins | 2020 |
Glecaprevir-pibrentasvir for chronic hepatitis C: Comparing treatment effect in patients with and without end-stage renal disease in a real-world setting.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Kidney Failure, Chronic; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Sustained Virologic Response | 2020 |
Effectiveness of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C virus infection and virologic failure to direct-acting antivirals.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2021 |
Real-Life Effectiveness and Safety of Glecaprevir/Pibrentasvir for Korean Patients with Chronic Hepatitis C at a Single Institution.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cohort Studies; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Middle Aged; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Republic of Korea; Retrospective Studies; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2021 |
Testicular Involvement is a Hallmark of Apo A-I Leu75Pro Mutation Amyloidosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyloidosis; Apolipoprotein A-I; Cohort Studies; Databases, Factual; Genetic Predisposition to Disease; Humans; Italy; Leucine; Male; Middle Aged; Mutation, Missense; Proline; Retrospective Studies; Testicular Diseases; Testis; Young Adult | 2020 |
Use of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus infection and severe renal impairment.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Child; Cyclopropanes; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency; Sulfonamides | 2020 |
Efficacy and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir for Hepatitis C Virus (HCV) NS5A-Inhibitor Experienced Patients With Difficult to Cure Characteristics.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2021 |
Sofosbuvir, velpatasvir, and voxilaprevir for patients with failure of previous direct-acting antiviral therapy for chronic hepatitis C: Results from the German Hepatitis C-Registry (DHC-R).
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Macrocyclic Compounds; Proline; Quinoxalines; Registries; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2020 |
Hepatitis C therapy with grazoprevir/elbasvir and glecaprevir/pibrentasvir in patients with advanced chronic kidney disease: data from the German Hepatitis C-Registry (DHC-R).
Topics: Amides; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Imidazoles; Lactams, Macrocyclic; Leucine; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Registries; Renal Insufficiency, Chronic; Ribavirin; Sulfonamides; Sustained Virologic Response | 2022 |
More evidence that direct acting antiviral therapy is safe and effective in cirrhosis and chronic kidney disease including peritoneal dialysis.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Peritoneal Dialysis; Proline; Pyrrolidines; Quinoxalines; Renal Insufficiency, Chronic; Sulfonamides | 2020 |
Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis.
Topics: Amides; Amino Acid Sequence; Cathepsin A; Cysteine; Hydrazines; Leucine; Peptides; Proline; Proteins; Structure-Activity Relationship; Sulfhydryl Compounds | 2020 |
Presentation and management of congenital myasthenic syndrome with a homozygous Agrin variant (Pro1448Leu).
Topics: Adolescent; Agrin; Cholinesterase Inhibitors; Diagnosis, Differential; Disease Management; Female; Genetic Variation; Homozygote; Humans; Leucine; Myasthenic Syndromes, Congenital; Proline; Pyridostigmine Bromide | 2020 |
Letter: now is the time to remove complexity from HCV guidelines to ensure that elimination remains a priority.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Letter: now is the time to remove complexity from HCV guidelines to ensure that elimination remains a priority-authors' reply.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2020 |
Is an 8-week regimen of glecaprevir/pibrentasvir sufficient for all hepatitis C virus infected patients in the real-world experience?
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides | 2021 |
Hepatitis C and beta-thalassemia major in children: experience with glecaprevir/pibrentasvir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; beta-Thalassemia; Child; China; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Feasibility and efficacy of 8 week Glecaprevir/Pibrentasvir to treat incarcerated viraemic HCV patients: A case-control study.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Case-Control Studies; Cyclopropanes; Feasibility Studies; Genotype; Hepacivirus; Hepatitis C; Humans; Italy; Lactams, Macrocyclic; Leucine; Middle Aged; Prisoners; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Tacrolimus concentrations were not affected by glecaprevir/pibrentasvir treatment for hepatitis C virus infection in an adult living donor liver transplant recipient with uremia.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Transplantation; Living Donors; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Tacrolimus; Uremia | 2021 |
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
Topics: 5-Methylcytosine; Adaptation, Physiological; Animals; Caenorhabditis elegans; CRISPR-Cas Systems; Cytosine; Gene Editing; Heat-Shock Response; Hot Temperature; Leucine; Methyltransferases; Mitochondria; Proline; Protein Biosynthesis; Ribosomes; RNA; RNA Processing, Post-Transcriptional | 2021 |
Reply to "Tacrolimus concentrations were not affected by glecaprevir/pibrentasvir treatment for hepatitis C virus infection in an adult living donor liver transplant recipient with uremia".
Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Drug Combinations; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Liver Transplantation; Living Donors; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Tacrolimus; Uremia | 2021 |
Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity.
Topics: Alanine; Aminopeptidases; Bacterial Proteins; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Hydrolases; Hydrophobic and Hydrophilic Interactions; Kinetics; Leucine; Models, Molecular; Mycobacterium tuberculosis; Phenylalanine; Proline; Prolyl Oligopeptidases; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Puromycin; Recombinant Proteins; Substrate Specificity | 2021 |
Exploring of paritaprevir and glecaprevir resistance due to A156T mutation of HCV NS3/4A protease: molecular dynamics simulation study.
Topics: Aminoisobutyric Acids; Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Lactams, Macrocyclic; Leucine; Molecular Dynamics Simulation; Mutation; Proline; Protease Inhibitors; Quinoxalines; Serine Proteases; Sulfonamides; Viral Nonstructural Proteins | 2022 |
Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.
Topics: Binding Sites; Cloning, Molecular; Coenzymes; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Kinetics; Leucine; Models, Molecular; Molecular Dynamics Simulation; Mutation; NADP; Proline; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; Substrate Specificity | 2021 |
Structural basis for a complex I mutation that blocks pathological ROS production.
Topics: Amino Acid Substitution; Animals; Cryoelectron Microscopy; Disease Models, Animal; Disease Resistance; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Humans; Isolated Heart Preparation; Leucine; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membranes; Myocardial Reperfusion Injury; NAD; NADH Dehydrogenase; Oxidation-Reduction; Point Mutation; Proline; Reactive Oxygen Species | 2021 |
Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Genetic Variation; HEK293 Cells; Histones; Humans; Lentivirus; Leucine; Mice; Mice, Nude; Mutation; Neoplasms; Nucleotides; Proline; Proto-Oncogene Proteins c-myc; Up-Regulation; Xenograft Model Antitumor Assays | 2021 |
Real-world effectiveness and safety of glecaprevir/pibrentasvir therapy in patients with chronic hepatitis C virus infection in Switzerland.
Topics: Adult; Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Switzerland | 2021 |
Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.
Topics: Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cyclopropanes; Cysteine Proteinase Inhibitors; Hepacivirus; Humans; Leucine; Proline; SARS-CoV-2; Sulfones; Urea | 2021 |
Changing epidemiology of patients treated with direct acting antivirals for HCV and persistently high SVR12 in an endemic area for HCV infection in Italy: real-life 'LIver Network Activity' (LINA) cohort update results.
Topics: Adult; Age Distribution; Aged; Amides; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzofurans; Carbamates; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Italy; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Sustained Virologic Response | 2021 |
Glecaprevir/pibrentasvir is safe and effective in hepatitis C patients with cirrhosis: Real-world data from the German Hepatitis C-Registry.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Registries; Sulfonamides; Sustained Virologic Response | 2021 |
Severe Liver Injury Associated with Glecaprevir Plus Pibrentasvir Therapy in a Patient with Treatment-naïve Hepatitis C Virus Infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Carbonates; Cathepsin L; Cell Line; Chlorocebus aethiops; Coronavirus 229E, Human; Coronavirus 3C Proteases; Coronavirus NL63, Human; Coronavirus OC43, Human; COVID-19 Drug Treatment; Drug Combinations; Glycoproteins; HEK293 Cells; Humans; Leucine; Middle East Respiratory Syndrome Coronavirus; Oligopeptides; Proline; SARS-CoV-2; Serine Endopeptidases; Sulfonic Acids; Vero Cells | 2021 |
Glecaprevir/pibrentasvir + sofosbuvir + ribavirin offers high cure rate for hepatitis C virus retreatment in real-world settings.
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retreatment; Ribavirin; Sofosbuvir; Sulfonamides | 2021 |
Salvage Therapy with Sofosbuvir/Velpatasvir/Voxilaprevir in DAA-experienced Patients: Results from a Prospective Canadian Registry.
Topics: Aminoisobutyric Acids; Antiviral Agents; Canada; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Quinoxalines; Registries; Salvage Therapy; Sofosbuvir; Sulfonamides | 2021 |
Resistance-associated substitutions after sofosbuvir/velpatasvir/voxilaprevir triple therapy failure.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Treatment Failure; Viral Nonstructural Proteins | 2021 |
Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study.
Topics: Antiviral Agents; Binding Sites; Computer Simulation; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Databases, Protein; Diarylquinolines; Dihydropyridines; Humans; Indoles; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitrobenzenes; Nitrophenols; Organophosphorus Compounds; Piperazines; Proline; Protease Inhibitors; Pyrrolidinones; SARS-CoV-2 | 2021 |
Reply to: "Glecaprevir/pibrentasvir + sofosbuvir + ribavirin offers high cure rate for hepatitis C virus retreatment in real-world settings".
Topics: Aminoisobutyric Acids; Benzimidazoles; Cyclopropanes; Hepacivirus; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retreatment; Ribavirin; Sofosbuvir; Sulfonamides | 2021 |
Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report.
Topics: Aminoisobutyric Acids; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Benzimidazoles; Cyclophosphamide; Cyclopropanes; Doxorubicin; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Prednisone; Proline; Pyrrolidines; Quinoxalines; Rituximab; RNA, Viral; Sulfonamides; Sustained Virologic Response; Vincristine; Viral Load | 2021 |
Improved Protein and PTM Characterization with a Practical Electron-Based Fragmentation on Q-TOF Instruments.
Topics: Disulfides; Electrons; Glycosylation; Insulin; Isoaspartic Acid; Leucine; Lysine; Mass Spectrometry; Phosphopeptides; Phosphorylation; Proline; Protein Processing, Post-Translational; Proteins; Software; Substance P | 2021 |
Effect of itraconazole on the pharmacokinetics of faldaprevir in healthy subjects.
Topics: Adult; Aminoisobutyric Acids; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Leucine; Male; Middle Aged; Proline; Quinolines; Thiazoles | 2021 |
Glecaprevir/pibrentasvir for 8 weeks in patients with compensated cirrhosis: Safety and effectiveness data from the German Hepatitis C-Registry.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Registries; Sulfonamides; Sustained Virologic Response | 2021 |
Inhibition of microbial production of the malodorous substance isovaleric acid by 4,4' dichloro 2-hydroxydiphenyl ether (DCPP).
Topics: Anti-Infective Agents; Corynebacterium; Hemiterpenes; Humans; Laundering; Leucine; Odorants; Oligopeptides; Pentanoic Acids; Proline; Pyridines; Skin; Staphylococcus aureus; Textiles | 2021 |
Sofosbuvir, Glecaprevir, Pibrentasvir, and Ribavirin as a Rescue Therapy in Difficult-to-Treat HCV Patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Monitoring; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Medication Therapy Management; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2021 |
Safety of Patients with Hepatitis C Virus Treated with Glecaprevir/Pibrentasvir from Clinical Trials and Real-World Cohorts.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carcinoma, Hepatocellular; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Sofosbuvir/Velpatasvir Plus Ribavirin Combination Therapy for Patients with Hepatitis C Virus Genotype 1a, 2a, or 3b after Glecaprevir/Pibrentasvir Therapy Failed.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Outcome | 2021 |
Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cholesterol, HDL; Cholesterol, LDL; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Non-pharmacologic direct cost of a simplified strategy with glecaprevir/pibrentasvir for 8 weeks in naïve non-cirrhotic patients with hepatitis C implemented in clinical practice. The Just SIMPLE Study.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides | 2022 |
Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332.
Topics: Antiviral Agents; Humans; Lactams; Leucine; Ligands; Molecular Dynamics Simulation; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; SARS-CoV-2; Software | 2021 |
In silico drug repurposing for the treatment of heart diseases using gene expression data and molecular docking techniques.
Topics: Aminoisobutyric Acids; Aminopterin; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Daunorubicin; Digoxin; Drug Repositioning; Gene Expression; Heart Diseases; Humans; Lactams, Macrocyclic; Leucine; Ligands; Methylergonovine; Molecular Docking Simulation; Morpholines; Proline; Quinoxalines; Sulfonamides | 2021 |
Effect of glecaprevir/pibrentasvir on weight-adjusted tacrolimus trough/dose ratios in heart and kidney transplant recipients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides; Tacrolimus; Transplant Recipients | 2021 |
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.
Topics: Coronavirus 3C Proteases; COVID-19; Cysteine; Humans; Lactams; Leucine; Nitriles; Peptides; Peptidomimetics; Proline; Protease Inhibitors; SARS-CoV-2; Structure-Activity Relationship; Substrate Specificity | 2021 |
High Sustained Virologic Response Rates of Glecaprevir/Pibrentasvir in Patients With Dosing Interruption or Suboptimal Adherence.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Female; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Medication Adherence; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2021 |
Computational simulations on the binding and reactivity of a nitrile inhibitor of the SARS-CoV-2 main protease.
Topics: Binding Sites; Catalytic Domain; Coronavirus 3C Proteases; COVID-19; Humans; Lactams; Leucine; Molecular Dynamics Simulation; Nitriles; Proline; Protease Inhibitors; Quantum Theory; SARS-CoV-2; Thermodynamics | 2021 |
Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations.
Topics: Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Coronavirus Protease Inhibitors; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Lopinavir; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2021 |
Sofosbuvir/velpatasvir/voxilaprevir for hepatitis C virus retreatment in decompensated cirrhosis.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Quinoxalines; Retreatment; Sofosbuvir; Sulfonamides | 2021 |
Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease.
Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19; Humans; Lactams; Leucine; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Proline; Protease Inhibitors; SARS-CoV-2 | 2022 |
Successful treatment of Japanese hemophilia patient co-infected with HIV and HCV genotype 4a by glecaprevir/pibrentasvir therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Coinfection; Cyclopropanes; Genotype; Hemophilia A; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Japan; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
[Glecaprevir/Pibrentasvir + Sofosbuvir + Ribavirin as a salvage regimen after Sofosbuvir + Velpatasvir + Voxilaprevir re-treatment failure].
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carbamates; Child; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Failure; Treatment Outcome | 2022 |
Cost-effectiveness analysis of glecaprevir/pibrentasvir regimen for treating Chinese patients with chronic hepatitis C genotype 1 and genotype 2 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; China; Cost-Benefit Analysis; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2021 |
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.
Topics: Antiviral Agents; Coronavirus 3C Proteases; COVID-19; Humans; Lactams; Leucine; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Proline; Protease Inhibitors; SARS-CoV-2 | 2022 |
Virtual Double-System Single-Box for Absolute Dissociation Free Energy Calculations in GROMACS.
Topics: Antiviral Agents; COVID-19; Entropy; Lactams; Leucine; Molecular Dynamics Simulation; Nitriles; Proline; SARS-CoV-2 | 2021 |
An oral SARS-CoV-2 M
Topics: Administration, Oral; Animals; Clinical Trials, Phase I as Topic; Coronavirus; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Therapy, Combination; Humans; Lactams; Leucine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Nitriles; Proline; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors; Virus Replication | 2021 |
The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
Topics: Adult; Alanine; Amidohydrolases; Antitubercular Agents; Aspartic Acid; Bacterial Proteins; Codon; Cross-Sectional Studies; Humans; Leucine; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Proline; Pyrazinamide; Tuberculosis, Multidrug-Resistant; Young Adult | 2022 |
Antiviral pills could change pandemic's course.
Topics: Antiviral Agents; Clinical Trials as Topic; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Tablets | 2021 |
Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Female; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Registries; Sulfonamides; Sustained Virologic Response; Taiwan; Treatment Outcome | 2021 |
Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Japan; Lactams, Macrocyclic; Leucine; Male; Persistent Infection; Phylogeny; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2022 |
In the age of Omicron variant: Paxlovid raises new hopes of COVID-19 recovery.
Topics: COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients.
Topics: Administration, Oral; Antibodies, Monoclonal; Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Approval; Drug Repositioning; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; United States; United States Food and Drug Administration | 2022 |
Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management.
Topics: COVID-19 Drug Treatment; Drug Interactions; Drug Therapy, Combination; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; Viral Protease Inhibitors | 2022 |
A National Strategy for COVID-19 Medical Countermeasures: Vaccines and Therapeutics.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; COVID-19 Vaccines; Cytidine; Drug Combinations; Endemic Diseases; Humans; Hydroxylamines; Immunization Schedule; Lactams; Leucine; Nitriles; Population Surveillance; Proline; Ritonavir; SARS-CoV-2; United States | 2022 |
COVID is here to stay: countries must decide how to adapt.
Topics: Adaptation, Psychological; Adult; Child; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Combinations; Endemic Diseases; Humans; Hydroxylamines; Immunity, Herd; Immunization, Secondary; International Cooperation; Lactams; Leucine; Nitriles; Physical Distancing; Proline; Reinfection; Ritonavir; SARS-CoV-2; Social Change; South Africa | 2022 |
COVID-19 Therapeutics for Nonhospitalized Patients.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; Child; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Female; Health Care Rationing; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Outpatients; Pregnancy; Proline; Ritonavir | 2022 |
Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection.
Topics: COVID-19; Drug Combinations; Humans; Kidney Transplantation; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Transplant Recipients | 2022 |
[A case of HCV genotype 3b with compensated stage cirrhosis who have two times treatment-experienced with the use of glecaprevir/pibrentasvir combined with sofosbuvir and ribavirin for 16 weeks].
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Treatment Outcome | 2021 |
Why scientists are racing to develop more COVID antivirals.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Approval; Drug Combinations; Drug Development; Drug Resistance, Viral; Drug Therapy, Combination; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Medication Adherence; Molecular Targeted Therapy; Mutagenesis; Nitriles; Proline; Public-Private Sector Partnerships; Research Personnel; Ritonavir; SARS-CoV-2 | 2022 |
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Microbial Sensitivity Tests; Nitriles; Proline; RNA-Dependent RNA Polymerase; SARS-CoV-2; Vero Cells; Virus Replication | 2022 |
Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQβ1.
Topics: Acute Disease; Alleles; Amino Acid Substitution; Black People; Female; Gene Expression; Genome-Wide Association Study; Genotype; Hepacivirus; Hepatitis C; HLA-DQ beta-Chains; Host-Pathogen Interactions; Humans; Leucine; Male; Polymorphism, Single Nucleotide; Proline; Protein Isoforms; Remission, Spontaneous; White People | 2022 |
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M
Topics: Animals; Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Embryonic Development; Female; Fertility; Infertility; Lactams; Leucine; Male; Nitriles; Pregnancy; Proline; Rabbits; Rats; Rats, Wistar; Ritonavir | 2022 |
COVID-19: LMICs need antivirals as well as vaccines.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Developed Countries; Developing Countries; Drug Costs; Healthcare Disparities; Hospitalization; Humans; Hydroxylamines; Lactams; Leucine; Licensure; Nitriles; Proline | 2022 |
Sofosbuvir-velpatasvir-voxilaprevir in adolescents 12 to 17 years old with HCV infection.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Carbamates; Child; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Quinoxalines; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome | 2022 |
Nirmatrelvir-ritonavir for COVID-19.
Topics: Administration, Oral; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors | 2022 |
Glecaprevir/Pibrentasvir and Renal Dysfunction in Deceased Donor Renal Transplantation: A Case Report.
Topics: Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Lactams, Macrocyclic; Leucine; Male; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2022 |
Paxlovid for treatment of COVID-19.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Combinations; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; Treatment Outcome; United States; United States Food and Drug Administration | 2022 |
Treatment of COVID-19 in high-risk outpatients.
Topics: Adenosine Monophosphate; Alanine; Ambulatory Care; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Outpatients; Proline; Ritonavir; Treatment Outcome | 2022 |
High Real-World Sustained Virologic Response Rate with Glecaprevir/Pibrentasvir at a Racially Diverse Urban Academic Medical Center.
Topics: Academic Medical Centers; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response | 2022 |
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Topics: Administration, Oral; Animals; Child; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A; Haplorhini; Humans; Lactams; Leucine; Microsomes, Liver; Nitriles; Peptide Hydrolases; Proline; Rats; Ritonavir; SARS-CoV-2 | 2022 |
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
Topics: A549 Cells; Administration, Oral; Animals; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Humans; Lactams; Leucine; Mesocricetus; Nitriles; Proline; Respiratory Mucosa; SARS-CoV-2; Vero Cells; Viral Protease Inhibitors; Virus Replication | 2022 |
Audio Interview: A New Antiviral against Covid-19.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Drug Combinations; Drug Interactions; Female; Humans; Immunity, Active; Immunogenicity, Vaccine; Lactams; Leucine; Male; Nitriles; Proline; Research Design; Ritonavir; Vaccine Efficacy; Viral Protease Inhibitors | 2022 |
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Nitriles; Pandemics; Peptide Hydrolases; Proline; Protease Inhibitors; SARS-CoV-2 | 2022 |
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Design; Drug Resistance, Viral; Fluorine; Halogenation; HCV NS3-4A Protease Inhibitors; Hepacivirus; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sulfonamides; Viral Proteases | 2022 |
The global COVID-19 treatment divide.
Topics: COVID-19 Drug Treatment; COVID-19 Testing; Developing Countries; Drug Combinations; Global Health; Health Services Accessibility; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir | 2022 |
Durability of sustained virological response to glecaprevir/pibrentasvir and resistance development: A long-term follow-up study.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Neoplasm Recurrence, Local; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Sustained Virologic Response | 2022 |
Hundreds of COVID trials could provide a deluge of new drugs.
Topics: Adenosine Monophosphate; Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Neutralizing; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Depsipeptides; Dexamethasone; Drug Combinations; Drug Repositioning; Drug Synergism; Esters; Guanidines; Hospitalization; Host-Pathogen Interactions; Humans; Hydroxylamines; Internationality; Lactams; Leucine; Mice; National Institutes of Health (U.S.); Nitriles; Peptide Elongation Factor 1; Peptides, Cyclic; Proline; Protease Inhibitors; Ritonavir; RNA-Dependent RNA Polymerase; SARS-CoV-2; Serine Endopeptidases; Sodium-Glucose Transporter 2 Inhibitors; United States; Virus Replication | 2022 |
Early clinical experience with nirmatrelvir/ritonavir for the treatment of COVID-19 in solid organ transplant recipients.
Topics: Adult; Calcineurin Inhibitors; COVID-19 Drug Treatment; Cyclosporine; Graft Rejection; Humans; Immunosuppressive Agents; Lactams; Leucine; Nitriles; Organ Transplantation; Proline; Retrospective Studies; Ritonavir; Sirolimus; Tacrolimus; Transplant Recipients | 2022 |
Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19.
Topics: Aminophenols; Benzodioxoles; Chloride Channel Agonists; COVID-19 Drug Treatment; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytochrome P-450 CYP3A; Drug Combinations; Drug Interactions; Humans; Indoles; Lactams; Leucine; Mutation; Nitriles; Proline; Pyrazoles; Pyridines; Pyrrolidines; Quinolines; Quinolones; Ritonavir | 2022 |
Oral Drugs Against COVID-19.
Topics: COVID-19; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir | 2022 |
African clinical trial denied access to key COVID drug Paxlovid.
Topics: Africa; Clinical Trials as Topic; COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Middle East Respiratory Syndrome Coronavirus; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus | 2022 |
Covid-19: What is the evidence for the antiviral Paxlovid?
Topics: Antiviral Agents; COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir | 2022 |
A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition.
Topics: COVID-19; Cysteine Endopeptidases; Humans; Indoles; Lactams; Leucine; Nitriles; Peptide Hydrolases; Proline; Protease Inhibitors; Pyrrolidinones; SARS-CoV-2; Viral Proteins | 2022 |
PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID-19 patients.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Endothelial Cells; Humans; Lactams; Leucine; Nitriles; Proline; SARS-CoV-2; United States | 2022 |
Gadoxetic acid-enhanced magnetic resonance imaging predicts hyperbilirubinemia induced by glecaprevir during hepatitis C virus treatment.
Topics: Aminoisobutyric Acids; Bilirubin; Cyclopropanes; Gadolinium DTPA; Hepacivirus; Hepatitis C; Humans; Hyperbilirubinemia; Lactams, Macrocyclic; Leucine; Magnetic Resonance Imaging; Proline; Quinoxalines; Sulfonamides | 2022 |
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cricetinae; Cytidine; Drug Combinations; Hydroxylamines; Indazoles; Lactams; Leucine; Mice; Nitriles; Proline; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Triazines; Triazoles | 2022 |
Real-world effectiveness and safety of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir for genotype 6 chronic hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzopyrans; Carbamates; Cyclopropanes; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Lipids; Proline; Pyrrolidines; Quinoxalines; Sofosbuvir; Sugars; Sulfonamides; Treatment Outcome | 2022 |
Metabolic characterization of amniotic fluid of fetuses with isolated choroid plexus cyst.
Topics: Amniotic Fluid; Arginine; Aspartic Acid; Choroid Plexus; Citrulline; Coenzyme A; Cysts; Ethanolamines; Female; Glucose; Humans; Hydroxylysine; Isoleucine; Leucine; Pregnancy; Proline; Ultrasonography, Prenatal; Valine | 2022 |
The future of Paxlovid for COVID-19.
Topics: COVID-19; Drug Combinations; Forecasting; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir | 2022 |
In Silico Evaluation of Paxlovid's Pharmacometrics for SARS-CoV-2: A Multiscale Approach.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT.
Topics: Antiviral Agents; COVID-19; Drug Combinations; Humans; Ivermectin; Lactams; Leucine; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Pandemics; Peptide Hydrolases; Proline; Protease Inhibitors; Ritonavir; SARS-CoV-2; Thermodynamics | 2022 |
Isolation and characterization of novel antihypertensive bioactive peptides from brassica napus and angiotensin-converting enzyme (ace) inhibition potential.
Topics: Alanine; Angiotensins; Antihypertensive Agents; Arginine; Brassica napus; Cysteine; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Peptides; Peptidyl-Dipeptidase A; Phenylalanine; Proline; Tandem Mass Spectrometry; Threonine; Tyrosine; Valine | 2022 |
Three more points about Paxlovid for covid-19.
Topics: COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
From Positive to Negative to Positive Again-The Mystery of Why COVID-19 Rebounds in Some Patients Who Take Paxlovid.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Testing; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Recurrence; Ritonavir; Viral Protease Inhibitors | 2022 |
High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Sulfonamides; Treatment Outcome | 2022 |
Physiologically-Based Pharmacokinetic Modeling-Guided Dose Management of Oral Anticoagulants when Initiating Nirmatrelvir/Ritonavir (Paxlovid) for COVID-19 Treatment.
Topics: Aged; Anticoagulants; COVID-19 Drug Treatment; Drug Combinations; Drug Interactions; Humans; Lactams; Leucine; Nitriles; Proline; Prospective Studies; Ritonavir; Rivaroxaban; Warfarin | 2022 |
Treatment outcomes of sofosbuvir/velpatasvir/voxilaprevir among NS5A inhibitor-experienced patients with hepatitis C: Real-world data from a multicenter Asian registry.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Registries; Sofosbuvir; Sulfonamides; Treatment Outcome | 2022 |
Hospitalization and Emergency Department Encounters for COVID-19 After Paxlovid Treatment - California, December 2021-May 2022.
Topics: COVID-19; COVID-19 Vaccines; Drug Combinations; Emergency Service, Hospital; Hospitalization; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
Non-responders to sofosbuvir/velpatasvir/voxilaprevir in the treatment of chronic hepatitis C infection.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Benzopyrans; Carbamates; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 4 or More Rings; Humans; Lactams, Macrocyclic; Leucine; Proline; Quinoxalines; Sofosbuvir; Sulfonamides | 2022 |
Covid-19: FDA authorises pharmacists to prescribe Paxlovid.
Topics: COVID-19; Drug Combinations; Drug Prescriptions; Humans; Lactams; Leucine; Nitriles; Pharmacists; Proline; Ritonavir | 2022 |
High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use: Some issues.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides | 2022 |
Paxlovid-Tacrolimus Drug-Drug Interaction in a 23-Year-Old Female Kidney Transplant Patient with COVID-19.
Topics: Adult; COVID-19; Drug Combinations; Drug Interactions; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Lactams; Leucine; Nitriles; Proline; Ritonavir; Tacrolimus; Young Adult | 2022 |
Interactions listed in the Paxlovid fact sheet, classified according to risks, pharmacological groups, and consequences.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.
Topics: Antiviral Agents; Carbamates; Carbutamide; COVID-19 Drug Treatment; Humans; Lactams; Leucine; Nitriles; Proline; Protease Inhibitors; SARS-CoV-2 | 2022 |
Paxlovid in patients who are immunocompromised and hospitalised with SARS-CoV-2 infection.
Topics: COVID-19; Drug Combinations; Humans; Immunocompromised Host; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
Successful nasoenteric administration of glecaprevir/pibrentasvir for donor-derived hepatitis C in two young adult heart transplant recipients at a pediatric transplant center.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Child; Cyclopropanes; Genotype; Heart Transplantation; Hepacivirus; Hepatitis C; Humans; Lactams, Macrocyclic; Leucine; Proline; Pyrrolidines; Quinoxalines; Sulfonamides; Young Adult | 2022 |
Bad news for Paxlovid? Resistance may be coming.
Topics: Coronavirus 3C Proteases; COVID-19 Drug Treatment; Drug Combinations; Drug Resistance, Viral; Humans; Lactams; Leucine; Mutation; Nitriles; Proline; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors | 2022 |
Genetic Surveillance of SARS-CoV-2 M
Topics: Animals; Antiviral Agents; Coronavirus 3C Proteases; COVID-19; Cysteine Endopeptidases; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Pandemics; Proline; Protease Inhibitors; Ritonavir; SARS-CoV-2; Viral Nonstructural Proteins | 2022 |
Rehospitalization, Emergency Visits After Paxlovid Treatment Are Rare.
Topics: Antiviral Agents; Drug Combinations; Emergency Service, Hospital; Hospitalization; Humans; Lactams; Leucine; Nitriles; Patient Readmission; Proline; Ritonavir | 2022 |
Real-World Safety, Effectiveness, and Patient-Reported Outcomes in Patients with Chronic Hepatitis C Virus Infection Treated with Glecaprevir/Pibrentasvir: Updated Data from the German Hepatitis C-Registry (DHC-R).
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Patient Reported Outcome Measures; Proline; Prospective Studies; Pyrrolidines; Quinoxalines; Registries; Sulfonamides | 2022 |
COVID-19 update: Prescription of Paxlovid by pharmacists.
Topics: Antiviral Agents; COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Pharmacists; Prescriptions; Proline; Ritonavir | 2022 |
A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Estrogen Receptor alpha; Estrogens; Female; Glutamic Acid; Humans; Leucine; Proline; Proteasome Endopeptidase Complex; Receptors, Estrogen; Transcription Factors | 2022 |
PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins; CTLA-4 Antigen; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Glutamates; Humans; Leucine; Lung Neoplasms; Proline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Transcription Factors | 2022 |
Comparison of 8- versus 12-weeks of glecaprevir/pibrentasvir for Taiwanese patients with hepatitis C and compensated cirrhosis in a real-world setting.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Proline; Pyrrolidines; Quinoxalines; Retrospective Studies; Sulfonamides | 2022 |
Rapid COVID-19 rebound in a severe COVID-19 patient during 20-day course of Paxlovid.
Topics: COVID-19; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir | 2022 |
Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge.
Topics: Adult; Aged; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Hospitalization; Humans; Lactams; Leucine; Middle Aged; Nitriles; Proline; SARS-CoV-2; Treatment Outcome | 2022 |
Characterisation of a Hepatitis C Virus Subtype 2a Cluster in Scottish PWID with a Suboptimal Response to Glecaprevir/Pibrentasvir Treatment.
Topics: Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Combinations; Genotype; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Phylogeny; Proline; Pyrrolidines; Quinoxalines; Scotland; Substance Abuse, Intravenous; Sulfonamides | 2022 |
Paxlovid Expiration Dates Extended.
Topics: Antiviral Agents; Drug Combinations; Drug Stability; Lactams; Leucine; Nitriles; Proline; Ritonavir; Time Factors | 2022 |
Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites.
Topics: Alanine; Ammonia; Antifungal Agents; Arginine; Aspartic Acid; Bacillus subtilis; Biotransformation; Carbon; Fusarium; Glutamic Acid; Glutamine; Glycine; Isoleucine; Leucine; Linoleic Acids; Linolenic Acids; Microarray Analysis; Nitrogen; Phenotype; Plant Diseases; Proline; RNA, Transfer; Solanum lycopersicum; Valine | 2022 |
Nirmatrelvir-Ritonavir and Viral Load Rebound in Covid-19.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Recurrence; Ritonavir; Viral Load | 2022 |
Rebound of SARS-CoV-2 Infection after Nirmatrelvir-Ritonavir Treatment.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Drug Combinations; Humans; Lactams; Leucine; Nitriles; Proline; Recurrence; Ritonavir; SARS-CoV-2 | 2022 |
Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Cysteine Endopeptidases; Lactams; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Peptide Hydrolases; Proline; SARS-CoV-2 | 2022 |
New Data on Paxlovid Reported.
Topics: COVID-19; Drug Combinations; Hospitalization; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2; Time Factors | 2022 |
Computational analysis and functional characterisation of Tor putitora toll-like receptor 4 with the elucidation of its binding sites for microbial mimicking ligands.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Carps; Cyprinidae; DNA, Complementary; Fish Proteins; Leucine; Ligands; Molecular Docking Simulation; Myeloid Differentiation Factor 88; Pathogen-Associated Molecular Pattern Molecules; Phylogeny; Proline; Receptors, Interleukin-1; Toll-Like Receptor 4; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins | 2022 |
Experience Using Paxlovid for Patients With Coronavirus Disease 2019 in a Resource-Limited Emergency Department.
Topics: COVID-19; Drug Combinations; Emergency Service, Hospital; Humans; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
[Determination of free amino acids in Eriocheir sinensis by ultra-high performance liquid chromatography-high resolution mass spectrometry].
Topics: Acetonitriles; Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Brachyura; Chromatography, High Pressure Liquid; Cystine; Formates; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Mass Spectrometry; Methionine; Perchlorates; Phenylalanine; Polypropylenes; Proline; Serine; Solvents; Threonine; Tyrosine; Valine; Water | 2022 |
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19.
Topics: Adenocarcinoma of Lung; Computational Biology; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Interleukin-17; Interleukin-6; Lactams; Leucine; Lung Neoplasms; Molecular Docking Simulation; Network Pharmacology; Nitriles; Proline; Receptors, Cytokine; Ritonavir; SARS-CoV-2; United States | 2022 |
[Cell metabolomics study of ginkgo flavone aglycone combined with doxorubicin against liver cancer in synergy].
Topics: Arginine; beta-Alanine; Doxorubicin; Flavones; Ginkgo biloba; Glutathione; Humans; Isoleucine; Leucine; Liver Neoplasms; Metabolomics; Phenylalanine; Proline; Tandem Mass Spectrometry; Tyrosine; Valine | 2022 |
A glycogen storage disease type 1a patient with type 2 diabetes.
Topics: Adenoma; Adult; Diabetes Mellitus, Type 2; Electrolytes; Female; Glucose; Glucose-6-Phosphatase; Glycogen Storage Disease Type I; Humans; Insulins; Leucine; Proline; Starch | 2022 |
Intestinal metabolomics of juvenile lenok (Brachymystax lenok) in response to heat stress.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Acetylcarnitine; Animals; Aspartic Acid; Erucic Acids; Glucose; Glutamine; Heat-Shock Response; Histidine; Intestines; Lactates; Leucine; Methionine; Oxylipins; Palmitoylcarnitine; Phenylalanine; Phosphatidylcholines; Phosphorylcholine; Proline; Salmonidae; Tandem Mass Spectrometry; Tryptophan; Tyrosine | 2022 |
Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Drug Combinations; Humans; Hydroxylamines; Lactams; Leucine; Nitriles; Proline; Ritonavir; SARS-CoV-2 | 2022 |
Paxlovid Drug Interaction Screening Checklist Updated.
Topics: Antiviral Agents; Checklist; Drug Combinations; Drug Interactions; Lactams; Leucine; Mass Screening; Nitriles; Proline; Ritonavir | 2022 |
[Serological Characteristics and Molecular Biological Mechanism of AEL.02 Subtype].
Topics: ABO Blood-Group System; Alleles; Genotype; Isoleucine; Leucine; Phenotype; Phenylalanine; Proline | 2022 |
Formulation, Characterisation and Evaluation of the Antihypertensive Peptides, Isoleucine-Proline-Proline and Leucine-Lysine-Proline in Chitosan Nanoparticles Coated with Zein for Oral Drug Delivery.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Caco-2 Cells; Chitosan; Drug Carriers; Humans; Leucine; Lysine; Nanoparticles; Oligopeptides; Particle Size; Peptides; Proline; Rats; Rats, Inbred SHR; Zein | 2022 |
Topics: Agaricales; Animals; Antioxidants; Arginine; Biomarkers; Diet, High-Fat; Fucose; Galactose; Glucose; Glycerides; Glycerol; Isoleucine; Leucine; Lipid Metabolism; Lipid Metabolism Disorders; Liver; Mannose; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phospholipids; Polysaccharides; Proline; Spectroscopy, Fourier Transform Infrared; Steroids; Valine; Xylose | 2022 |
Expanding the Landscape of Amino Acid-Rich Antimicrobial Peptides: Definition, Deployment in Nature, Implications for Peptide Design and Therapeutic Potential.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antimicrobial Peptides; Arginine; Leucine; Mammals; Peptide Fragments; Peptides; Proline; Trypsin | 2022 |
Metabolomics profiling of seminal plasma in obesity-induced asthenozoospermia.
Topics: Aconitic Acid; Alanine; Asthenozoospermia; Citrulline; Glucose; Glutamic Acid; Glycine; Humans; Leucine; Lysine; Male; Metabolomics; Phenylalanine; Proline; Semen; Serine; Succinic Acid; Threonine; Tyrosine; Valine | 2023 |
Plasma amino acids by age and gender in Hangzhou, Eastern China.
Topics: Amino Acids; Arginine; Chromatography, Liquid; Female; Glycine; Humans; Isoleucine; Leucine; Male; Phenylalanine; Proline; Tandem Mass Spectrometry; Valine | 2023 |
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.
Topics: Antiviral Agents; Binding Sites; Coronavirus 3C Proteases; COVID-19; Drug Design; Drug Resistance, Viral; Humans; Lactams; Leucine; Mutation; Nitriles; Proline; SARS-CoV-2; Substrate Specificity; Virus Replication | 2023 |
Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in rats with cerebral ischemia-reperfusion injury.
Topics: Animals; Biomarkers; Brain Ischemia; Cerebral Infarction; China; Chromatography, High Pressure Liquid; Erigeron; Ischemic Stroke; Leucine; Metabolomics; Molecular Docking Simulation; Proline; Rats; Reperfusion Injury; Tandem Mass Spectrometry | 2024 |
Intraspecific genetic lineages of a marine mussel show behavioural divergence when exposed to microplastic leachates.
Topics: Adult; Animals; Cysteine; Humans; Leucine; Microplastics; Mytilus; Plastics; Proline | 2024 |