proline has been researched along with guvacine in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Brahce, L; Gregor, VE; Lobbestael, SJ; Mayhugh, DR; Nugiel, D; Pavia, MR; Schwarz, RD; Taylor, CP; Vartanian, MG | 1 |
| Andersen, KE; Braestrup, C; Grønwald, FC; Jørgensen, AS; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD; Sørensen, PO | 1 |
| Andersen, KE; Henry, RF; Knutsen, LJ; Lau, J; Lundt, BF; Morton, HE; Naerum, L; Petersen, H; Stephensen, H; Suzdak, PD; Swedberg, MD; Sørensen, PO; Thomsen, C | 1 |
| Frydenvang, K; Frølund, B; Krogsgaard-Larsen, P | 1 |
| Holm, R; Lagunas, C; Nielsen, CU; Plum, J; Rasmussen, RN | 1 |
1 review(s) available for proline and guvacine
| Article | Year |
|---|---|
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood-Brain Barrier; Drug Design; gamma-Aminobutyric Acid; Humans; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Prodrugs; Proline; Structure-Activity Relationship | 2000 |
5 other study(ies) available for proline and guvacine
| Article | Year |
|---|---|
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzhydryl Compounds; Blood-Brain Barrier; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Mice; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Proline; Rats; Structure-Activity Relationship | 1992 |
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Topics: Animals; Anticonvulsants; GABA Antagonists; gamma-Aminobutyric Acid; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Proline; Prosencephalon; Rats; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tiagabine | 1993 |
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carrier Proteins; Crystallography, X-Ray; Drug Design; Ethers; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Membrane Proteins; Membrane Transport Proteins; Models, Molecular; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Rats; Structure-Activity Relationship; Synaptic Transmission | 1999 |
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
Topics: Aminolevulinic Acid; Animals; beta-Alanine; Caco-2 Cells; Cell Line; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kidney; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Osmolar Concentration; Osmosis; Proline; Rats; RNA, Messenger; Swine; Taurine; Vigabatrin | 2016 |