proline and danoprevir

proline has been researched along with danoprevir in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	52 (86.67)	24.3611
2020's	8 (13.33)	2.80

Authors

Authors	Studies
Deutsch, M; Papatheodoridis, GV	1
Bae, A; Chen, X; Harris, J; Ku, K; Miller, MD; Mo, H; Qi, X; Sun, SC; Wong, KA; Worth, A	1
Benhamou, Y; Bradford, B; Couzigou, P; Forestier, N; Guyader, D; Larrey, D; Marcellin, P; Moucari, R; Seiwert, S; Vidaud, M; Voitot, H; Zeuzem, S	1
Thomas, DL	1
Angus, PW; Baher, L; Berrey, MM; Bradford, W; Chu, T; Elston, R; Gane, EJ; Ipe, D; Laughlin, M; Lopatin, U; Morcos, PN; Najera, I; Ritchie, B; Roberts, SK; Shulman, NS; Smith, PF; Stedman, CA	1
Blatt, L; Bradford, W; Forestier, N; Guyader, D; Larrey, D; Marcellin, P; Patat, A; Porter, S; Rouzier, R; Seiwert, SD; Smith, P; Zeuzem, S	1
Chang, L; Gane, EJ; Horban, A; Nájera, I; Rouzier, R; Sampeur, P; Shulman, NS; Smith, P; Stedman, C; Tran, JQ; Wiercinska-Drapalo, A; Zhang, Y	1
Imhof, I; Simmonds, P	1
Bradford, W; Kossen, K; Lim, SR; Lin, JH; Pan, L; Schaefer, CJ; Seiwert, SD; Smith, PF	1
Brennan, BJ; Connor, A; Evans, P; Fretland, A; McLawhon, P; Morcos, PN; Reddy, MB; Smith, P; Tran, JQ; Zhou, A	1
Bukh, J; Ghanem, L; Gottwein, JM; Jensen, TB; Scheel, TK	1
Khungar, V; Poordad, F	1
Bradford, W; Forestier, N; Guyader, D; Larrey, D; Lim, S; Marcellin, P; Patat, A; Porter, S; Qin, X; Rouzier, R; Seiwert, SD; Smith, PF; Zeuzem, S	1
Ciesek, S; Manns, MP; von Hahn, T	1
Arfsten, A; Bradford, W; Herrmann, E; Hong, J; Hooi, L; Kossen, K; Lange, C; Lim, SR; Nájera, I; Nicholas, JB; Qin, X; Sarrazin, C; Seiwert, SD; Smith, P; Susser, S; Zeuzem, S	1
Angus, PW; Chu, TW; Elston, R; Gane, EJ; Germer, S; Iglesias, VA; Ipe, D; Kulkarni, R; Lopatin, U; Lu, XY; Ritchie, B; Roberts, SK; Shulman, NS; Smith, PF; Stedman, C	1
Baker, SJ; Crosby, R; Ding, CZ; Duan, M; Gartland, M; Hamatake, R; Ji, J; Kazmierski, W; Li, X; Liu, Y; Plattner, JJ; Tallant, M; Wang, A; Wright, L; Wu, M; Zhang, S; Zhang, YK; Zhou, Y	1
Benhamou, Y; Boyer, N; Carenco, C; Guyader, D; Larrey, D; Marcellin, P; Pageaux, GP; Rouzier, R	1
Blotner, S; Chen, Y; Fretland, J; Haznedar, JO; Reddy, MB; Smith, P; Tran, JQ	1
Liu, H; Pan, D; Xue, W; Yao, X; Zhang, W	1
Jin, X; Liu, H; Wang, M; Xue, W; Yao, X	1
Ali, S; Chhabra, M; Chin, DJ; Ilnicka, M; Kang, H; Klumpp, K; Kosaka, A; Le Pogam, S; Nájera, I; Shulman, NS; Smith, P; Yan, JM	1
Ali, A; Aydin, C; Cao, H; Deveau, LM; Huang, W; Newton, A; Ozen, A; Petropoulos, CJ; Romano, KP; Schiffer, CA; Silver, C; Soumana, D	1
Coffield, DJ; Dahari, H; Guedj, J; Levi, M; Perelson, AS; Rong, L; Smith, P	1
Andrews, SW; Ballard, J; Beigelman, L; Blatt, L; Brandhuber, BJ; Buckman, B; Condroski, KR; Doherty, GA; Geck Do, M; Jiang, Y; Josey, JA; Kennedy, AL; Lemieux, C; Lyon, M; Madduru, MR; Seiwert, SD; Serebryany, V; Stengel, P; Vigers, G; Wang, B; Wenglowsky, S; Woodard, BT; Zhang, H	1
Asthappan, J; Brennan, BJ; Goelzer, P; Morcos, PN; Moreira, SA; Navarro, MT; Smith, PF; Weigl, P	1
Balart, L; Box, T; Brunda, M; Buggisch, P; Cooper, C; Ferenci, P; Hooper, G; Labriola-Tompkins, E; Larrey, D; Lawitz, E; Le Pogam, S; Lim, CY; Marcellin, P; Nájera, I; Navarro, MT; Shulman, NS; Terrault, NA; Thomas, D; Weltman, M; Yetzer, ES; Yoshida, E; Zhang, Y	1
Brennan, BJ; Chang, L; Giraudon, M; Kulkarni, R; Morcos, PN; Shulman, N; Smith, PF; Tran, JQ	1
Bech, N; Brennan, BJ; Morcos, PN; Moreira, SA; Navarro, MT; Smith, PF	1
Bech, N; Brennan, BJ; Morcos, PN; Moreira, SA; Navarro, MT; Quatkemeyer, A; Smith, PF	1
Brennan, BJ; Chang, L; Chung, D; Morcos, PN; Navarro, M; Smith, PF; Tran, JQ	1
Brennan, BJ; Gane, EJ; Kulkarni, R; Larrey, DG; Le Pogam, S; Morcos, PN; Nájera, I; Petric, R; Rouzier, R; Shulman, NS; Smith, P; Tran, JQ; Wiercinska-Drapalo, A; Yetzer, ES; Zhang, Y	1
Andreone, P; Beltran-Jaramillo, T; Brunda, M; Bruno, S; Cooper, C; Everson, G; Ferenci, P; Hézode, C; Le Pogam, S; Nájera, I; Navarro, MT; Shiffman, ML; Shulman, NS; Voulgari, A; Yetzer, ES; Yoshida, E; Zeuzem, S; Zhou, J	1
Anwar, MI; Danielson, UH; Ehrenberg, AE; Gustafsson, SS; Schmuck, B; Stenberg, G	1
Haines, K; Li, L; Najera, I; Tong, X	1
Martinez, MA; Parera, M	1
Ballester, R; Bernaards, C; Bertasso, A; Dwyer, C; Gane, EJ; Hammond, J; Kindrick, A; Marcellin, P; Morcos, PN; Nájera, I; Pockros, PJ; Shikhman, A; Shulman, NS; Smith, P; Stancic, S; Tong, X; Yetzer, ES; Zeuzem, S; Zhou, J	1
Chowdhury, AY; George, SL; Tavis, JE	1
Berak, H; Eng, S; Feld, JJ; Foster, GR; Hooper, GJ; Jablkowski, M; Jacobson, IM; Jensen, DM; Kulkarni, R; Le Pogam, S; Lim, CY; Nájera, I; Navarro, MT; Perez-Gomez, HR; Pol, S; Scalori, A; Shahdad, S; Shulman, NS; Tam, E; Tavel, JA; Vierling, JM; Yetzer, ES; Yoshida, EM	1
Brennan, B; Canini, L; Chatterjee, A; Guedj, J; Lemenuel-Diot, A; Perelson, AS; Smith, PF	1
Badran, AH; Dickinson, BC; Liu, DR; Packer, MS	1
Asthappan, J; Brennan, BJ; Funk, C; Goelzer, P; Morcos, PN; Moreira, S; Poirier, A; Portmann, R; Smith, PF	1
Brunda, M; Chu, T; Elston, R; Gane, EJ; George, J; Glavini, K; Hammond, JM; Jensen, DM; Le Pogam, S; Nájera, I; Passe, S; Piekarska, A; Rodriguez, I; Zeuzem, S	1
Canini, L; Chatterjee, A; Guedj, J; Lemenuel-Diot, A; Perelson, AS; Smith, PF	1
Brennan, BJ; Eng, S; Gane, EJ; Hassanein, T; Kupcova, V; Le Pogam, S; Mazur, W; Morcos, PN; Rouzier, R; Scalori, A; Stedman, CA; Thommes, J; Voulgari, A	1
Brennan, BJ; Hill, G; Kao, JH; Le Pogam, S; Lee, Y; Li, H; Najera, I; Sheen, IS; Tanwandee, T; Thommes, JA; Thongsawat, S; Tung, SY; Wu, JJ; Zhou, J	1
Canini, L; Guedj, J; Perelson, AS	1
Srinivas, NR	1
Hannongbua, S; Kungwan, N; Meeprasert, A; Rungrotmongkol, T	1
Chen, CY; Chen, MY; Chen, Q; Kao, JH; Peng, CY; Tang, H; Wu, JJ; Yu, ML	1
Ellis, S	1
Keam, SJ; Markham, A	1
Miyake, T	1
Chen, H; Huang, Y; Ju, W; Li, X; Peng, X; Rao, J; Sun, H; Tu, X; Wang, L; Wang, S; Zhang, Z; Zhu, D	1
Ajaz, SJ; Banday, AH; Shameem, SA	1
De Clercq, E; Jing, X; Li, G; Miao, M	1
Talluri, S	1
Chen, H; Chen, Y; Gong, F; Huang, Z; Li, X; Wang, L; Wu, JJ; Zhang, Z	1
Feng, K; Huang, P; Ke, L; Lin, C; Liu, J; Pan, S; Yang, X; Zeng, Y	1
Lin, M; Lv, D; Shentu, J; Wu, G; Wu, J; Wu, JJ; Wu, L; Zhai, Y; Zhou, H	1

Reviews

4 review(s) available for proline and danoprevir

Article	Year
Emerging therapeutic options in hepatitis C virus infection. The American journal of managed care, 2011, Volume: 17 Suppl 4 Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication	2011
Second-wave protease inhibitors: choosing an heir. Clinics in liver disease, 2011, Volume: 15, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2011
Danoprevir: First Global Approval. Drugs, 2018, Volume: 78, Issue:12 Topics: Antiviral Agents; China; Cyclopropanes; Dose-Response Relationship, Drug; Drug Approval; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Proline; Ribavirin; Ritonavir; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins	2018
Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy. Drug design, development and therapy, 2020, Volume: 14 Topics: Antiviral Agents; Cyclopropanes; Enzyme Inhibitors; Genotype; Hepacivirus; Hepatitis C; Humans; Isoindoles; Lactams, Macrocyclic; Microbial Sensitivity Tests; Proline; Serine Proteases; Sulfonamides; Viral Nonstructural Proteins	2020

Trials

30 trial(s) available for proline and danoprevir

Article	Year
Danoprevir, an HCV NS3/4A protease inhibitor, improves insulin sensitivity in patients with genotype 1 chronic hepatitis C. Gut, 2010, Volume: 59, Issue:12 Topics: Adult; Antiviral Agents; Cyclopropanes; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Insulin Resistance; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Proline; Protease Inhibitors; RNA, Viral; Sulfonamides; Viral Load; Viral Nonstructural Proteins	2010
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet (London, England), 2010, Oct-30, Volume: 376, Issue:9751 Topics: Administration, Oral; Adult; Antiviral Agents; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; RNA, Viral; Sulfonamides; Viral Nonstructural Proteins	2010
Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: a phase 1b multiple ascending dose study. Journal of hepatology, 2011, Volume: 54, Issue:6 Topics: Adult; Aged; Alanine Transaminase; Antiviral Agents; Carrier Proteins; Cyclopropanes; Double-Blind Method; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Serine Proteinase Inhibitors; Sulfonamides; Viral Load; Viral Nonstructural Proteins	2011
Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN α-2a/RBV in hepatitis C patients. Journal of hepatology, 2011, Volume: 55, Issue:5 Topics: Adult; Antiviral Agents; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides; Time Factors	2011
Danoprevir monotherapy decreases inflammatory markers in patients with chronic hepatitis C virus infection. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:7 Topics: 2',5'-Oligoadenylate Synthetase; Antiviral Agents; Chemokine CXCL10; Cyclopropanes; Hepatitis C, Chronic; Humans; Inflammation; Isoindoles; Lactams; Lactams, Macrocyclic; Liver; Neopterin; Proline; RNA, Viral; Sulfonamides	2011
Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible. Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:5 Topics: Administration, Oral; Adult; Animals; Antiviral Agents; Biological Availability; Cross-Over Studies; Cyclopropanes; Delayed-Action Preparations; Feasibility Studies; Humans; Intestinal Absorption; Isoindoles; Lactams; Lactams, Macrocyclic; Macaca fascicularis; Male; Models, Biological; Proline; Sulfonamides; Young Adult	2011
Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon α-2a and ribavirin in patients with hepatitis C. The Journal of infectious diseases, 2011, Aug-15, Volume: 204, Issue:4 Topics: Antiviral Agents; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Sulfonamides; Viral Nonstructural Proteins	2011
Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1 Topics: Amino Acid Substitution; Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Molecular; Molecular Typing; Mutation; Proline; Protease Inhibitors; Protein Structure, Tertiary; Recombinant Proteins; Recurrence; RNA, Viral; Species Specificity; Sulfonamides; Viral Load; Viral Nonstructural Proteins; Viral Proteins; Virus Replication	2012
Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology, 2012, Volume: 142, Issue:4 Topics: Antiviral Agents; Australia; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Isoindoles; Kinetics; Lactams; Lactams, Macrocyclic; Models, Biological; Models, Statistical; New Zealand; Phenotype; Polymorphism, Single Nucleotide; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load; Virus Replication	2012
Impact of low-dose ritonavir on danoprevir pharmacokinetics: results of computer-based simulations and a clinical drug-drug interaction study. Clinical pharmacokinetics, 2012, Jul-01, Volume: 51, Issue:7 Topics: Adult; Computer Simulation; Cross-Over Studies; Cyclopropanes; Drug Interactions; Female; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Models, Biological; Proline; Protease Inhibitors; Ritonavir; Sulfonamides; Viral Nonstructural Proteins; Young Adult	2012
Characterization of hepatitis C virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11 Topics: Adult; Antiviral Agents; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Mutation; Placebos; Proline; RNA, Viral; Sulfonamides; Viral Load; Viral Nonstructural Proteins	2012
Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin. Clinical pharmacokinetics, 2013, Volume: 52, Issue:9 Topics: Adult; Animals; Antiviral Agents; CHO Cells; Cricetulus; Cross-Over Studies; Cyclopropanes; Cyclosporine; Drug Interactions; Female; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Proline; Ritonavir; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides	2013
Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis C virus genotype 1 infection. Gastroenterology, 2013, Volume: 145, Issue:4 Topics: Adult; Antiviral Agents; Cyclopropanes; Drug Therapy, Combination; Epoxy Compounds; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Pyridines; Recombinant Proteins; Ribavirin; Sulfonamides	2013
A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail. European journal of clinical pharmacology, 2013, Volume: 69, Issue:11 Topics: Adult; Antiviral Agents; Aryl Hydrocarbon Hydroxylases; Cyclopropanes; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Midazolam; Middle Aged; Proline; Ritonavir; Sulfonamides; Vitamin K; Warfarin; Young Adult	2013
Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy. Pharmacotherapy, 2014, Volume: 34, Issue:3 Topics: Adolescent; Adult; Aged; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Methadone; Middle Aged; Opiate Substitution Treatment; Proline; Protease Inhibitors; Ritonavir; Sulfonamides; Young Adult	2014
Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers. The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:1 Topics: Adult; Area Under Curve; Cross-Over Studies; Cyclopropanes; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Meals; Neuropeptides; Omeprazole; Proline; Ranitidine; Ritonavir; Sulfonamides; Young Adult	2014
Two-way interaction study between ritonavir boosted danoprevir, a potent HCV protease inhibitor, and ketoconazole in healthy subjects. International journal of clinical pharmacology and therapeutics, 2014, Volume: 52, Issue:2 Topics: Adult; Area Under Curve; Cyclopropanes; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Isoindoles; Ketoconazole; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Proline; Ritonavir; Sulfonamides	2014
Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:2 Topics: Adult; Alanine Transaminase; Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Mutation; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load; Viral Nonstructural Proteins	2014
DAUPHINE: a randomized phase II study of danoprevir/ritonavir plus peginterferon alpha-2a/ribavirin in HCV genotypes 1 or 4. Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:1 Topics: Adult; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Polyethylene Glycols; Proline; Recombinant Proteins; Ritonavir; RNA, Viral; Sulfonamides	2015
Identification of the NS5B S282T resistant variant and two novel amino acid substitutions that affect replication capacity in hepatitis C virus-infected patients treated with mericitabine and danoprevir. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6 Topics: Adult; Amino Acid Substitution; Antiviral Agents; Base Sequence; Cyclopropanes; Deoxycytidine; DNA Replication; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Molecular Sequence Data; Mutation; Phenotype; Proline; RNA, Viral; Sequence Analysis, DNA; Sulfonamides; Viral Nonstructural Proteins	2014
Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study. Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:1 Topics: Adult; Aged; Cyclopropanes; Deoxycytidine; Electrocardiography; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Proline; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides	2015
Randomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin. Journal of hepatology, 2015, Volume: 62, Issue:2 Topics: Cyclopropanes; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Carriers; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Retrospective Studies; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome	2015
A pharmacokinetic/viral kinetic model to evaluate the treatment effectiveness of danoprevir against chronic HCV. Antiviral therapy, 2015, Volume: 20, Issue:5 Topics: Antiviral Agents; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Theoretical; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sulfonamides; Treatment Outcome; Viral Load; Viral Nonstructural Proteins	2015
Interferon-free regimens containing setrobuvir for patients with genotype 1 chronic hepatitis C: a randomized, multicenter study. Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:4 Topics: Adult; Antiviral Agents; Australia; Benzothiadiazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; New Zealand; Phenotype; Proline; Quinolones; Remission Induction; Ribavirin; RNA, Viral; Sulfonamides; Time Factors; Treatment Outcome; United States; Viral Load	2016
Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection. Antiviral therapy, 2016, Volume: 21, Issue:4 Topics: Antiviral Agents; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Biological; Proline; RNA, Viral; Sulfonamides; Viral Load	2016
Ritonavir-boosted danoprevir-based regimens in treatment-naive and prior null responders with HCV genotype 1 or 4 and compensated cirrhosis. Hepatology international, 2016, Volume: 10, Issue:3 Topics: Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Female; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Liver Cirrhosis; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Ritonavir; Sulfonamides; Treatment Failure	2016
Ritonavir-boosted danoprevir plus peginterferon alfa-2a and ribavirin in Asian chronic hepatitis C patients with or without cirrhosis. Journal of gastroenterology and hepatology, 2016, Volume: 31, Issue:10 Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Liver Cirrhosis; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; Ritonavir; RNA, Viral; Sulfonamides; Young Adult	2016
Twelve-week ravidasvir plus ritonavir-boosted danoprevir and ribavirin for non-cirrhotic HCV genotype 1 patients: A phase 2 study. Journal of gastroenterology and hepatology, 2018, Volume: 33, Issue:8 Topics: Administration, Ophthalmic; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asian People; Cyclopropanes; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Liver Cirrhosis; Male; Middle Aged; Proline; Ribavirin; Ritonavir; Sulfonamides; Time Factors; Treatment Outcome	2018
First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients. Medicine, 2020, Nov-25, Volume: 99, Issue:48 Topics: Adolescent; Adult; Aged; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cyclopropanes; Drug Therapy, Combination; Female; Humans; Isoindoles; Lactams, Macrocyclic; Male; Middle Aged; Pandemics; Proline; Real-Time Polymerase Chain Reaction; Ritonavir; SARS-CoV-2; Sulfonamides; Tomography, X-Ray Computed; Young Adult	2020
Pharmacokinetics, Safety, and Tolerability of Ravidasvir, with and without Danoprevir/Ritonavir, in Healthy Subjects. Antimicrobial agents and chemotherapy, 2021, 09-17, Volume: 65, Issue:10 Topics: Adult; Area Under Curve; Benzimidazoles; Cyclopropanes; Healthy Volunteers; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Proline; Ritonavir; Sulfonamides; Valine	2021

Other Studies

26 other study(ies) available for proline and danoprevir

Article	Year
Danoprevir, a small-molecule NS3/4A protease inhibitor for the potential oral treatment of HCV infection. Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:8 Topics: Animals; Antiviral Agents; Clinical Trials as Topic; Cyclopropanes; Dogs; Drug Evaluation, Preclinical; Drug Therapy, Combination; Haplorhini; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Polyethylene Glycols; Proline; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Ribavirin; Ritonavir; Sulfonamides; Viral Nonstructural Proteins	2010
Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Antiviral Agents; Cell Line, Tumor; Cyclopropanes; Hepacivirus; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Molecular Structure; Oligopeptides; Proline; Protease Inhibitors; Simeprevir; Sulfonamides	2010
Curing hepatitis C with pills: a step toward global control. Lancet (London, England), 2010, Oct-30, Volume: 376, Issue:9751 Topics: Administration, Oral; Antiviral Agents; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Proline; Sulfonamides; Viral Nonstructural Proteins	2010
Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191). Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:4 Topics: Amino Acid Substitution; Cell Line, Tumor; Cyclopropanes; Drug Resistance, Viral; Genotype; Hepacivirus; Humans; Inhibitory Concentration 50; Isoindoles; Lactams; Lactams, Macrocyclic; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Viral Nonstructural Proteins; Virus Replication	2011
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses. Gastroenterology, 2011, Volume: 141, Issue:3 Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cyclopropanes; Genotype; Hepacivirus; Hepatitis C; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Liver Neoplasms; Molecular Sequence Data; Oligopeptides; Proline; Protease Inhibitors; Sulfonamides; Treatment Outcome; Viral Nonstructural Proteins	2011
Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease. Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8 Topics: Cyclopropanes; Drug Discovery; Hepacivirus; Humans; Hydroxylation; Inhibitory Concentration 50; Isoindoles; Lactams; Lactams, Macrocyclic; Molecular Structure; Mutation; Proline; Protease Inhibitors; Sulfonamides; Viral Nonstructural Proteins	2012
Sustained virological response after 14-day treatment with danoprevir and 48-week treatment with pegylated interferon-α2a (40 KD) plus ribavirin. Antiviral therapy, 2012, Volume: 17, Issue:5 Topics: Adult; Aged; Antiviral Agents; Cyclopropanes; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; Retrospective Studies; Ribavirin; Sulfonamides; Time Factors; Treatment Outcome; Viral Load	2012
Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: a computational study. Biochimica et biophysica acta, 2012, Volume: 1820, Issue:10 Topics: Alanine; Amino Acid Substitution; Antiviral Agents; Arginine; Aspartic Acid; Comprehension; Computational Biology; Cyclopropanes; Drug Resistance, Viral; Glutamic Acid; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Lysine; Models, Molecular; Molecular Dynamics Simulation; Mutation, Missense; Proline; Sulfonamides; Valine; Viral Nonstructural Proteins	2012
Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis. Molecular bioSystems, 2012, Volume: 8, Issue:10 Topics: Amino Acids; Antiviral Agents; Catalytic Domain; Crystallography, X-Ray; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Isoindoles; Kinetics; Lactams; Lactams, Macrocyclic; Molecular Dynamics Simulation; Mutation; Proline; Protease Inhibitors; Protein Conformation; Protein Structure, Tertiary; RNA Helicases; Sulfonamides; Thermodynamics; Viral Nonstructural Proteins	2012
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS pathogens, 2012, Volume: 8, Issue:7 Topics: Antiviral Agents; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfonamides; Viral Nonstructural Proteins	2012
Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model. PLoS computational biology, 2013, Volume: 9, Issue:3 Topics: Antiviral Agents; Computational Biology; Cyclopropanes; Hepacivirus; Hepatitis C; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Biological; Proline; RNA, Viral; Sulfonamides; Virus Replication	2013
Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease. Journal of medicinal chemistry, 2014, Mar-13, Volume: 57, Issue:5 Topics: Animals; Antiviral Agents; Crystallography, X-Ray; Cyclopropanes; Dogs; Drug Discovery; Isoindoles; Lactams; Lactams, Macrocyclic; Macaca fascicularis; Molecular Structure; Proline; Protease Inhibitors; Rats; Sulfonamides; Viral Nonstructural Proteins	2014
Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2014, Volume: 29, Issue:6 Topics: Antiviral Agents; Carbamates; Cloning, Molecular; Cyclopropanes; Drug Resistance, Viral; Escherichia coli; Gene Expression; Genetic Variation; Genotype; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Macrocyclic Compounds; Mutation; Oligopeptides; Proline; Protease Inhibitors; Protein Structure, Tertiary; Quinolines; Recombinant Proteins; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2014
Strong epistatic interactions within a single protein. Molecular biology and evolution, 2014, Volume: 31, Issue:6 Topics: Amino Acid Substitution; Catalytic Domain; Cyclopropanes; Enzyme Inhibitors; Epistasis, Genetic; Evolution, Molecular; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Mutagenesis, Site-Directed; Mutation Rate; Phylogeny; Proline; Sulfonamides; Viral Nonstructural Proteins	2014
Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors. Virology, 2014, Volume: 456-457 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Line; Cyclopropanes; DNA Mutational Analysis; GB virus C; Host-Pathogen Interactions; Humans; Interferon Type I; Isoindoles; Lactams; Lactams, Macrocyclic; Mutant Proteins; Oligopeptides; Proline; Protease Inhibitors; RNA Helicases; Serine Endopeptidases; Sulfonamides; Viral Nonstructural Proteins	2014
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nature communications, 2014, Oct-30, Volume: 5 Topics: Amino Acid Sequence; Bacteriophage M13; Cyclopropanes; Drug Resistance, Viral; Evolution, Molecular; Gene Expression; Genetic Techniques; Hepacivirus; Humans; Isoindoles; Isoquinolines; Lactams; Lactams, Macrocyclic; Molecular Sequence Data; Mutation; Peptide Hydrolases; Proline; Protease Inhibitors; Sulfonamides; Viral Proteins	2014
Characterization of the transmembrane transport and absolute bioavailability of the HCV protease inhibitor danoprevir. Clinical pharmacokinetics, 2015, Volume: 54, Issue:5 Topics: Adolescent; Adult; Animals; Antiviral Agents; Biological Availability; Carcinoma, Lewis Lung; CHO Cells; Cricetinae; Cricetulus; Cross-Over Studies; Cyclopropanes; Cyclosporine; Dogs; Drug Interactions; Female; Hepatocytes; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Madin Darby Canine Kidney Cells; Male; Membrane Transport Proteins; Middle Aged; Proline; Protease Inhibitors; Randomized Controlled Trials as Topic; Ritonavir; Sulfonamides; Swine; Young Adult	2015
Reply to: Danoprevir pharmacokinetic/viral kinetic model for treating chronic HCV - some considerations. Antiviral therapy, 2016, Volume: 21, Issue:7 Topics: Cyclopropanes; Hepatitis C; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Proline; Sulfonamides	2016
Danoprevir pharmacokinetic/viral kinetic model for treating chronic HCV - some considerations. Antiviral therapy, 2016, Volume: 21, Issue:7 Topics: Antiviral Agents; Cyclopropanes; Hepatitis C; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Biological; Proline; Sulfonamides	2016
Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir. Molecular bioSystems, 2016, 11-15, Volume: 12, Issue:12 Topics: Amino Acid Substitution; Aminoisobutyric Acids; Binding Sites; Catalytic Domain; Codon; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Humans; Hydrogen Bonding; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Molecular Conformation; Mutation; Oligopeptides; Proline; Protein Binding; Quinolines; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2016
Chinese approval for Ascletis' HCV drug is first homegrown success. Nature biotechnology, 2018, 08-06, Volume: 36, Issue:8 Topics: Antiviral Agents; Biotechnology; China; Cyclopropanes; Drug Approval; Government Agencies; Hepatitis C, Chronic; Humans; Investments; Isoindoles; Lactams; Lactams, Macrocyclic; Proline; Sulfonamides; Virus Replication	2018
Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats. Biological & pharmaceutical bulletin, 2020, Mar-01, Volume: 43, Issue:3 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzimidazoles; Biological Availability; Cyclopropanes; Cyclosporine; Fluorenes; Gene Knockout Techniques; Isoindoles; Isoquinolines; Lactams, Macrocyclic; Male; Metabolic Clearance Rate; Oral Mucosal Absorption; Proline; Rats; Rats, Sprague-Dawley; Simeprevir; Sulfonamides	2020
A comparative study on the time to achieve negative nucleic acid testing and hospital stays between danoprevir and lopinavir/ritonavir in the treatment of patients with COVID-19. Journal of medical virology, 2020, Volume: 92, Issue:11 Topics: Adolescent; Adult; Aged; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; COVID-19 Nucleic Acid Testing; Cyclopropanes; Drug Combinations; Female; Humans; Isoindoles; Lactams, Macrocyclic; Length of Stay; Lopinavir; Male; Middle Aged; Proline; Ritonavir; Severity of Illness Index; Sulfonamides; Young Adult	2020
Potential Repurposed Therapeutics and New Vaccines against COVID-19 and Their Clinical Status. SLAS discovery : advancing life sciences R & D, 2020, Volume: 25, Issue:10 Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiviral Agents; Chloroquine; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cyclopropanes; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Mice, Transgenic; Proline; Pyrazines; SARS-CoV-2; Small Molecule Libraries; Sulfonamides; Vaccines, Synthetic	2020
Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19. Combinatorial chemistry & high throughput screening, 2021, Volume: 24, Issue:5 Topics: Antiviral Agents; Benzazepines; COVID-19; COVID-19 Drug Treatment; Cyclopropanes; Darunavir; Drug Evaluation, Preclinical; Drug Repositioning; High-Throughput Screening Assays; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Molecular Docking Simulation; Proline; Saquinavir; SARS-CoV-2; Sulfonamides	2021
Efficacy and safety of danoprevir plus sofosbuvir in GT 1, 2, 3, or 6 chronic hepatitis C patients with or without cirrhosis in China. Medicine, 2021, Jun-18, Volume: 100, Issue:24 Topics: Adult; Antiviral Agents; China; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams, Macrocyclic; Liver Cirrhosis; Male; Middle Aged; Proline; Prospective Studies; Ribavirin; RNA, Viral; Sofosbuvir; Sulfonamides; Sustained Virologic Response	2021