proline has been researched along with cnv1014802 in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 6 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Ettlin, DA; Giblin, GM; Gunn, K; Morisset, V; Obermann, M; Palmer, J; Tate, S; Zakrzewska, JM | 1 |
| Alewood, PF; Dekan, Z; Deuis, JR; Durek, T; Hoffmann, T; Lewis, RJ; Nassar, MA; Sousa, SR; Vetter, I; Weidner, C; Wingerd, JS; Winter, Z; Zimmermann, K | 1 |
| Skolnick, P; Volkow, ND | 1 |
| Bendtsen, L; Cruccu, G; Derjean, D; Estacion, M; Ettlin, DA; Giblin, GM; Gunn, K; Layton, G; Morisset, V; Obermann, M; Palmer, J; Tate, S; Waxman, SG; Zakrzewska, JM | 1 |
| Gao, ZB; Li, YF; Wang, WF; Yu, Y; Zheng, YM | 1 |
| Ballow, CH; Fong, R; Naik, H; Palmer, J; Steiner, D; White, WB | 1 |
| Cruccu, G; Di Stefano, G; Truini, A | 1 |
| Obermann, M | 1 |
| Dunbar, J; Giblin, GMP; Morisset, V; Naik, H; Palmer, J; Tate, S; Tidemann-Miller, B; Versavel, M; Zhao, Y | 1 |
| Christmann, R; Naik, H; Tidemann-Miller, B; Versavel, M; Zhao, Y | 1 |
| Barre, A; Buisson, B; Hajos, M; Hinckley, CA; Kuryshev, Y; Naik, H; Sers, A | 1 |
| Bockbrader, H; Chapel, S; Cleall, S; Forrestal, F; Naik, H; Zhao, Y | 1 |
| Gu, C; Huang, J; Johnson, JL; Rooney, M | 1 |
| Finnigan, H; Kotecha, M; Naik, H; Serenko, M; Zhao, Y | 1 |
3 review(s) available for proline and cnv1014802
| Article | Year |
|---|---|
Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia.
Topics: Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; Drug Therapy, Combination; Gabapentin; Humans; Lamotrigine; Oxcarbazepine; Phenyl Ethers; Proline; Sodium Channel Blockers; Trigeminal Neuralgia | 2018 |
Recent advances in understanding/managing trigeminal neuralgia.
Topics: Carbamazepine; Humans; Phenyl Ethers; Proline; Quality of Life; Radiosurgery; Sodium Channel Blockers; Transcranial Direct Current Stimulation; Trigeminal Neuralgia | 2019 |
Population Pharmacokinetics of Vixotrigine in Healthy Volunteers and Subjects with Trigeminal Neuralgia, Painful Lumbosacral Radiculopathy and Erythromelalgia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Asian People; Biological Availability; Erythromelalgia; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Models, Biological; Phenyl Ethers; Proline; Radiculopathy; Tissue Distribution; Trigeminal Neuralgia; Voltage-Gated Sodium Channel Blockers; Young Adult | 2021 |
5 trial(s) available for proline and cnv1014802
| Article | Year |
|---|---|
Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia.
Topics: Double-Blind Method; Humans; Outcome Assessment, Health Care; Phenyl Ethers; Proline; Research Design; Sodium Channel Blockers; Trigeminal Neuralgia; Withholding Treatment | 2013 |
Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.
Topics: Adult; Aged; Area Under Curve; Double-Blind Method; Electrocardiography; Female; Humans; International Cooperation; Kaplan-Meier Estimate; Male; Middle Aged; Phenyl Ethers; Proline; Retrospective Studies; Sodium Channel Blockers; Treatment Outcome; Trigeminal Neuralgia; Young Adult | 2017 |
Effects of a State- and Use-Dependent Nav1.7 Channel Blocker on Ambulatory Blood Pressure: A Randomized, Controlled Crossover Study.
Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Models, Biological; NAV1.7 Voltage-Gated Sodium Channel; Phenyl Ethers; Proline; Sodium Channel Blockers; Young Adult | 2019 |
Evaluation of the Pharmacokinetic Interaction Between the Voltage- and Use-Dependent Nav1.7 Channel Blocker Vixotrigine and Carbamazepine in Healthy Volunteers.
Topics: Adult; Analgesics, Non-Narcotic; Carbamazepine; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Male; NAV1.7 Voltage-Gated Sodium Channel; Phenyl Ethers; Proline; Voltage-Gated Sodium Channel Blockers; Young Adult | 2020 |
Evaluation of the Effect of Uridine Diphosphate-Glucuronosyltransferases (UGT) Inhibition by Valproic Acid on Vixotrigine Pharmacokinetics in Healthy Volunteers.
Topics: Area Under Curve; Glucuronosyltransferase; Healthy Volunteers; Humans; Phenyl Ethers; Proline; Sodium Channel Blockers; Uridine Diphosphate; Valproic Acid | 2022 |
6 other study(ies) available for proline and cnv1014802
| Article | Year |
|---|---|
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.
Topics: Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetulus; Disease Models, Animal; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; NAV1.7 Voltage-Gated Sodium Channel; Nerve Fibers; Pain; Peptides; Phenyl Ethers; Proline; Saphenous Vein; Scorpion Venoms; Sodium Channel Blockers; Spider Venoms; Sulfonamides | 2016 |
Re-energizing the Development of Pain Therapeutics in Light of the Opioid Epidemic.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Chronic Pain; Drug Discovery; Epidemics; Humans; Opioid-Related Disorders; Pain Management; Phenyl Ethers; Pregabalin; Proline | 2016 |
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802.
Topics: Analgesics; Animals; CHO Cells; Cricetulus; Electrophysiological Phenomena; HEK293 Cells; Humans; Mutagenesis, Site-Directed; Mutation; NAV1.7 Voltage-Gated Sodium Channel; Phenyl Ethers; Proline; Voltage-Gated Sodium Channel Blockers | 2018 |
Evaluation of the Potential Pharmacokinetic Interactions Between Vixotrigine and an Oral Contraceptive.
Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Drug Interactions; Ethinyl Estradiol; Female; Humans; Levonorgestrel; Middle Aged; Phenyl Ethers; Proline; Young Adult | 2020 |
Characterization of Vixotrigine, a Broad-Spectrum Voltage-Gated Sodium Channel Blocker.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; HEK293 Cells; Humans; Male; Phenyl Ethers; Proline; Rats; Rats, Sprague-Dawley; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2021 |
Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes.
Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Humans; Hydrogen-Ion Concentration; Hydrolysis; Liver; Microsomes, Liver; Phenyl Ethers; Proline | 2022 |