proline and bi 201335

proline has been researched along with bi 201335 in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	60 (98.36)	24.3611
2020's	1 (1.64)	2.80

Authors

Authors	Studies
Bailey, MD; Bhardwaj, PK; Bordeleau, J; Bös, M; Bousquet, Y; Cordingley, MG; Duan, J; Forgione, P; Garneau, M; Ghiro, E; Gorys, V; Goudreau, N; Goulet, S; Halmos, T; Kawai, SH; Llinàs-Brunet, M; Naud, J; Poupart, MA; White, PW	1
Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Kukolj, G; Lagacé, L; Llinàs-Brunet, M; Thibeault, D; White, PW	1
Benhamou, Y; Berg, T; Boecher, WO; Bonacini, M; Bourlière, M; Calleja, JL; Kukolj, G; Manns, MP; Pol, S; Scherer, J; Steinmann, G; Stern, JO; Trepo, C; White, PW; Wright, D; Yong, CL	1
Goudreau, N; Hucke, O; Lemke, CT; Llinàs-Brunet, M; Thibeault, D; White, PW; Zhao, S	1
Khungar, V; Poordad, F	1
Ciesek, S; Manns, MP; von Hahn, T	1
Angus, P; Arasteh, K; Asselah, T; Boecher, WO; Bronowicki, JP; Gane, E; Haefner, C; Heim, M; Kukolj, G; Larrey, D; Lohse, A; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F	1
Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; De Marte, J; Duan, J; Garneau, M; Jutras, M; Llinàs-Brunet, M; Montpetit, H; Otis, F; Rhéaume, M; White, PW; Yong, CL	1
Bousquet, C; Dansereau, N; Dô, F; Kukolj, G; Lagacé, L; Llinas-Brunet, M; Marquis, M; Massariol, MJ; Maurice, R; Spickler, C; Thibeault, D; Triki, I; White, PW; Zhao, S	1
Lok, AS; Sharma, P	1
Asselah, T; Bessone, F; Böcher, WO; Datsenko, Y; Fainboim, H; Ferenci, P; Heo, J; Kukolj, G; Lalezari, J; Leggett, B; Mauss, S; Nehmiz, G; Scherer, J; Steinmann, GG; Stern, JO; Sulkowski, MS	1
Angus, P; Arasteh, K; Asselah, T; Böcher, WO; Bronowicki, JP; Gane, E; Heim, M; Kukolj, G; Larrey, D; Lohse, AW; Mensa, FJ; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F	1
Berger, KL; Bethell, R; Cartier, M; Kukolj, G; Lagacé, L; Lawetz, C; Marquis, M; Scherer, J; Triki, I	1
Asselah, T; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Kukolj, G; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Vinisko, R; Zeuzem, S	1
Kuboki, M; Nishiguchi, S; Omata, M; Sakai, Y; Sakamoto, W; Steinmann, G; Tsuda, Y; Tsunematsu, S; Urano, Y	1
Bichoupan, K; Dieterich, DT; Martel-Laferrière, V	1
Berger, KL; Böcher, WO; Cartier, M; Datsenko, Y; Kukolj, G; Marquis, M; Massariol, MJ; Scherer, J; Steinmann, G; Stern, JO; Triki, I	1
Busacca, CA; Gonnella, N; Li, Y; O'Brien, D; Ramsden, D; Taub, ME; Tweedie, DJ; Xu, J; Zhou, J	1
Laufer, NL; Rockstroh, JK	1
Chan, TS; Li, Y; Ramsden, D; Taub, ME; Tweedie, DJ	1
Chen, LZ; Li, Y; Ramsden, D; St George, R; Tweedie, DJ	1
Boccaccio, V; Bruno, S	1
Dieterich, DT; Martel-Laferrière, V	1
Asselah, T; Marcellin, P	1
Asselah, T; Halfon, P; Marcellin, P; Schinazi, R	1
Benhamou, Y; Shiffman, ML	1
Ford, N; Fortunak, J; Hill, A; Khoo, S; Simmons, B	1
Chen, LZ; Huang, F; Latli, B; Li, Y; Mandarino, D; Mao, Y; Rose, P; St George, R; Yong, CL	1
Shiffman, ML	1
Asselah, T; Berg, T; Böcher, WO; Datsenko, Y; Dieterich, D; Ferenci, P; Guyader, D; Larrey, D; Maieron, A; Mauss, S; Ozan, M; Ratziu, V; Schuchmann, M; Steinmann, G; Stern, JO	1
Agarwal, K; Austin, A; Barclay, ST; Brown, A; Dillon, JF; Dundas, P; Dusheiko, GM; Foster, GR; Fox, R; Hayes, PC; Leen, C; Miller, MH; Millson, C; Ryder, SD; Tait, J; Ustianowski, A	1
Chen, L; George, RS; Mao, Y; Norris, SH; Philip, E; Potchoiba, MJ; Wang, LQ; Wu, D	1
Böcher, WO; Hennecke, N; Kayser, A; Kukolj, G; Lohmann, V; Martin, B; Neumann-Haefelin, C; Thimme, R	1
Ballow, C; Battegay, M; Elgadi, M; Feifel, U; Fuhr, R; Girlich, B; Haschke, M; Kort, J; Lang, B; Li, Y; Sabo, JP; Schobelock, M	1
Asselah, T; Böcher, WO; Huang, Q; Li, Y; Mease, K; Nehmiz, G; Olson, S; Podila, L; Sane, RS; Steinmann, GG; Stern, JO; Taub, ME; Tweedie, D	1
Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Gallivan, JP; Mantry, P; Mensa, FJ; Soriano, V; Stern, JO; Taunk, J; Vinisko, R; Zeuzem, S	1
Elgadi, M; Halabi, A; Huang, F; Lang, B; Moschetti, V; Petersen-Sylla, M; Yong, CL	1
Elgadi, M; Garcia, J; Huang, F; Joseph, D; Rose, P; Schultz, A; Strelkowa, N	1
Adeniji, A; Elgadi, M; Huang, F; Joseph, D; Riesenberg, RR; Schobelock, MJ; Vince, BD; Webster, LR	1
Elgadi, M; Huang, F; Lang, B; Sabo, JP	1
Ballow, C; Battegay, M; Chan, TS; Cooper, C; Girlich, B; Haschke, M; Kashuba, AD; Kort, J; Lang, B; Li, Y; O'Brien, D; Sabo, JP; Seibert, E; Ting, N; Tweedie, D; Zhang, W	1
Angus, P; Asselah, T; Böcher, W; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Manns, M; Mensa, FJ; Müllhaupt, B; Roberts, S; Sabo, JP; Schuchmann, M; Soriano, V; Stern, JO; Stickel, F; Voss, F; Zeuzem, S	1
Agarwal, K; Asselah, T; Bourlière, M; Calinas, F; Crespo, J; Datsenko, Y; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; Garcia, M; Kukolj, G; Maevskaya, M; Morano, LE; Moreno, C; Nishiguchi, S; Omata, M; Ouzan, D; Quinson, AM; Sarrazin, C; Scherer, J; Schuchmann, M; Stern, JO; Zehnter, E; Zeuzem, S	1
Agarwal, K; Barnabas, A	1
Arastéh, K; Bhagani, S; Dieterich, D; Guardiola, JM; Ingiliz, P; Jain, MK; Kort, J; Laguno, M; Manero, M; Nelson, M; Rockstroh, JK; Soriano, V; Stern, JO; Tural, C; Vinisko, R	1
Kanda, T; Omata, M; Yokosuka, O	1
Campagna, D; Demma, S	1
Ambrosioni, J; Aouri, M; Böni, J; Cavassini, M; Decosterd, L; Fehr, J; Furrer, H; Günthard, HF; Haubitz, S; Kovari, H; Ledergerber, B; Metzner, KJ; Rauch, A; Schaerer, V; Schmid, P; Stoeckle, M	1
Berger, KL; Kukolj, G; Quinson, AM; Ranga, M; Scherer, J; Sha, N; Stern, JO	1
Asselah, T; Bourlière, M; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; García-Samaniego, J; Maevskaya, M; Mantry, P; Oliveira, C; Quinson, AM; Sha, N; Stern, JO; Warner, N; Wright, D; Wright, M; Yoshida, EM	1
Asselah, T; Baum, P; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Voss, F; Zeuzem, S	1
Elgadi, M; Gießmann, T; Huang, F; Lang, B; Wu, J	1
Angus, P; Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Kadus, W; Mantry, P; Mensa, FJ; Pockros, PJ; Soriano, V; Stern, JO; Vinisko, R; Wright, D; Zeuzem, S	1
Busacca, CA; Davis, M; Ding, A; Gonnella, NC; Grupe, J; Herfurth, L; Jones, PJ; Li, G; Niemann, M; Offerdahl, T; Reckzügel, G; Reddig, T; Roos, H; Saha, A; Wagner, K; Werthmann, U; Wu, JP; Zhang, L	1
Berger, KL; Côté-Martin, A; Kukolj, G; Marquis, M; Mensa, FJ; Nelson, DR; Sarrazin, C; Scherer, J; Sha, N; Stern, JO; Vinisko, R	1
Hannongbua, S; Kungwan, N; Meeprasert, A; Rungrotmongkol, T	1
Bai, X; Calleja, JL; Forns, X; Garcia-Samaniego, J; Kaste, R; Manns, M; Sarrazin, C; Stern, JO; Wu, J	1
Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Quinson, AM; Strelkowa, N	1
Du, W; Gou, X; Hu, J; Liang, L; Liu, W; Zuo, K	1
Huang, F; Rowland, L; Sabo, JP; Schultz, A; Trampisch, M; Voelk, C	1
Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Strelkowa, N	1

Reviews

13 review(s) available for proline and bi 201335

Article	Year
Emerging therapeutic options in hepatitis C virus infection. The American journal of managed care, 2011, Volume: 17 Suppl 4 Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication	2011
Second-wave protease inhibitors: choosing an heir. Clinics in liver disease, 2011, Volume: 15, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2011
Hepatitis C direct-acting antiviral agents: changing the paradigm of hepatitis C treatment in HIV-infected patients. Journal of clinical gastroenterology, 2014, Volume: 48, Issue:2 Topics: Aminoisobutyric Acids; Antiviral Agents; Coinfection; Hepatitis C; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferons; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2014
Faldaprevir (BI 201335) for the treatment of hepatitis C in patients co-infected with HIV. Expert review of anti-infective therapy, 2014, Volume: 12, Issue:2 Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Availability; Clinical Trials as Topic; Coinfection; Drug Administration Schedule; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Virus Replication	2014
Management of HCV patients with cirrhosis with direct acting antivirals. Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1 Topics: Algorithms; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Liver Cirrhosis; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate	2014
Treating HCV in HIV 2013: on the cusp of change. Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1 Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine	2014
Second-wave IFN-based triple therapy for HCV genotype 1 infection: simeprevir, faldaprevir and sofosbuvir. Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1 Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate	2014
HCV direct-acting antiviral agents: the best interferon-free combinations. Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1 Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials as Topic; Disease Eradication; Drug Discovery; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon-alpha; Isoquinolines; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pyrrolidines; Quinolines; Recombinant Proteins; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine; Viral Nonstructural Proteins; Virus Replication	2014
HCV F1/F2 patients: treat now or continue to wait. Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34 Suppl 1 Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Treatment Outcome; Uridine Monophosphate	2014
Hepatitis C virus therapy in the direct acting antiviral era. Current opinion in gastroenterology, 2014, Volume: 30, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Sofosbuvir; Thiazoles; Uridine Monophosphate	2014
Faldaprevir for the treatment of genotype-1 hepatitis C virus. Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Ribavirin; Thiazoles	2015
Faldaprevir for the treatment of hepatitis C. International journal of molecular sciences, 2015, Mar-04, Volume: 16, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Thiazoles; Viral Nonstructural Proteins	2015
Faldaprevir for the treatment of hepatitis C. Drugs of today (Barcelona, Spain : 1998), 2015, Volume: 51, Issue:5 Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Discovery; Drug Interactions; Hepatitis C; Humans; Leucine; Molecular Structure; Oligopeptides; Proline; Quinolines; Thiazoles; Tissue Distribution; Treatment Outcome; Viral Nonstructural Proteins	2015

Trials

29 trial(s) available for proline and bi 201335

Article	Year
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection. Journal of hepatology, 2011, Volume: 54, Issue:6 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Load; Viral Nonstructural Proteins	2011
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastroenterology, 2011, Volume: 141, Issue:6 Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Thiazoles; Treatment Outcome; Viral Load; Viral Nonstructural Proteins	2011
Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial. Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:6 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Nonstructural Proteins	2013
Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results. Antiviral therapy, 2013, Volume: 18, Issue:8 Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load	2013
Viral resistance in hepatitis C virus genotype 1-infected patients receiving the NS3 protease inhibitor Faldaprevir (BI 201335) in a phase 1b multiple-rising-dose study. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:10 Topics: Aminoisobutyric Acids; Antiviral Agents; Cell Line; Genotype; Genotyping Techniques; Hepacivirus; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins	2013
Faldaprevir and deleobuvir for HCV genotype 1 infection. The New England journal of medicine, 2013, Aug-15, Volume: 369, Issue:7 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; DNA-Directed RNA Polymerases; Enzyme Inhibitors; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load	2013
Safety and efficacy of faldaprevir with pegylated interferon alfa-2a and ribavirin in Japanese patients with chronic genotype-1 hepatitis C infection. Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34, Issue:1 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Asian People; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Time Factors; Treatment Outcome	2014
Mass balance and metabolite profiling of steady-state faldaprevir, a hepatitis C virus NS3/4 protease inhibitor, in healthy male subjects. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:4 Topics: Adolescent; Adult; Aminoisobutyric Acids; Hepacivirus; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Young Adult	2014
SILEN-C3, a phase 2 randomized trial with faldaprevir plus pegylated interferon α-2a and ribavirin in treatment-naive hepatitis C virus genotype 1-infected patients. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6 Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles; Viral Nonstructural Proteins; Young Adult	2014
Restoration of HCV-specific CD8+ T cell function by interferon-free therapy. Journal of hepatology, 2014, Volume: 61, Issue:3 Topics: Acrylates; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Contraindications; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Virus Replication	2014
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Nov-15, Volume: 59, Issue:10 Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult	2014
Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients. The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:2 Topics: Aminoisobutyric Acids; Animals; Bilirubin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Hyperbilirubinemia; Leucine; Liver; Macaca mulatta; Multicenter Studies as Topic; Multidrug Resistance-Associated Protein 2; Oligopeptides; Proline; Quinolines; Randomized Controlled Trials as Topic; Rats; Thiazoles	2014
Interferon-free treatment of chronic hepatitis C with faldaprevir, deleobuvir and ribavirin: SOUND-C3, a Phase 2b study. Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:2 Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Treatment Outcome	2015
Pharmacokinetics, safety, and tolerability of faldaprevir in patients with renal impairment. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1 Topics: Adult; Aged; Aminoisobutyric Acids; Biological Availability; Female; Half-Life; Hepatitis C; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Renal Insufficiency; Thiazoles	2015
Effect of faldaprevir on raltegravir pharmacokinetics in healthy volunteers. Journal of clinical pharmacology, 2015, Volume: 55, Issue:4 Topics: Adult; Aminoisobutyric Acids; Drug Administration Schedule; Drug Interactions; Female; Genotype; Glucuronosyltransferase; Healthy Volunteers; HIV Integrase Inhibitors; Humans; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Raltegravir Potassium; Thiazoles; Young Adult	2015
Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1 Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Interactions; Female; Humans; Leucine; Male; Methadone; Middle Aged; Oligopeptides; Proline; Quinolines; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles; Young Adult	2015
Effect of the hepatitis C virus protease inhibitor faldaprevir on the pharmacokinetics of an oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Aminoisobutyric Acids; Area Under Curve; Bilirubin; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Leucine; Levonorgestrel; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins; Young Adult	2015
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation. Journal of clinical pharmacology, 2015, Volume: 55, Issue:4 Topics: Adolescent; Adult; Aminoisobutyric Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Hepatitis C; Humans; In Vitro Techniques; Isoenzymes; Leucine; Male; Microsomes, Liver; Midazolam; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Warfarin; Young Adult	2015
Efficacy and safety of faldaprevir, deleobuvir, and ribavirin in treatment-naive patients with chronic hepatitis C virus infection and advanced liver fibrosis or cirrhosis. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:2 Topics: Acrylates; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Female; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Ribavirin; Thiazoles; Young Adult	2015
STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection. Journal of hepatology, 2015, Volume: 62, Issue:6 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles	2015
Faldaprevir and pegylated interferon α-2a/ribavirin in individuals co-infected with hepatitis C virus genotype-1 and HIV. AIDS (London, England), 2015, Mar-13, Volume: 29, Issue:5 Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Leucine; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load; Viremia; Young Adult	2015
Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10 Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins	2015
Open-label study of faldaprevir plus peginterferon and ribavirin in hepatitis C virus genotype 1-infected patients who failed placebo plus peginterferon and ribavirin. Journal of viral hepatitis, 2016, Volume: 23, Issue:3 Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Placebos; Proline; Quinolines; Ribavirin; Salvage Therapy; Thiazoles; Treatment Outcome	2016
ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection. PloS one, 2015, Volume: 10, Issue:12 Topics: Acrylates; Aminoisobutyric Acids; Anemia; Antiviral Agents; Benzimidazoles; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Male; Middle Aged; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Pyrophosphatases; Quinolines; Real-Time Polymerase Chain Reaction; Ribavirin; Thiazoles	2015
Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants. The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:4 Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Food-Drug Interactions; Healthy Volunteers; Hepacivirus; Humans; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Oligopeptides; Omeprazole; Proline; Protease Inhibitors; Proton Pump Inhibitors; Quinolines; Risk Factors; Thiazoles; Viral Nonstructural Proteins; Young Adult	2016
Short article: Faldaprevir, deleobuvir and ribavirin in IL28B non-CC patients with HCV genotype-1a infection included in the SOUND-C3 phase 2b study. European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:8 Topics: Acrylates; Adult; Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Leucine; Male; Middle Aged; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA, Viral; Sustained Virologic Response; Thiazoles; Time Factors; Treatment Outcome; United States	2016
HCVerso3: An Open-Label, Phase IIb Study of Faldaprevir and Deleobuvir with Ribavirin in Hepatitis C Virus Genotype-1b-Infected Patients with Cirrhosis and Moderate Hepatic Impairment. PloS one, 2016, Volume: 11, Issue:12 Topics: Acrylates; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Prognosis; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Viral Load; Young Adult	2016
Effect of Steady-State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open-Label, Fixed-Sequence Crossover Study. Journal of clinical pharmacology, 2017, Volume: 57, Issue:10 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Atorvastatin; Cross-Over Studies; Drug Interactions; Female; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Male; Middle Aged; Oligopeptides; Proline; Pyrimidines; Quinolines; Rosuvastatin Calcium; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles	2017
Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study. Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:1 Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Graft Rejection; Healthy Volunteers; Hepatitis C; Humans; Immunosuppressive Agents; Leucine; Liver Transplantation; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Quinolines; Secondary Prevention; Tacrolimus; Thiazoles; Young Adult	2018

Other Studies

19 other study(ies) available for proline and bi 201335

Article	Year
Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335). Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17 Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Hepacivirus; Humans; Leucine; Male; Microsomes, Liver; Oligopeptides; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Replicon; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins	2010
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11 Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication	2010
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. The Journal of biological chemistry, 2011, Apr-01, Volume: 286, Issue:13 Topics: Aminoisobutyric Acids; Carrier Proteins; Catalytic Domain; Clinical Trials, Phase I as Topic; Crystallography, X-Ray; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Proline; Protease Inhibitors; Protein Binding; Quinolines; Thiazoles; Viral Nonstructural Proteins	2011
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor. Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:2 Topics: Absorption; Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Caco-2 Cells; Dogs; Drug Evaluation, Preclinical; Hepacivirus; Humans; Leucine; Macaca mulatta; Male; Microsomes, Liver; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution; Viral Nonstructural Proteins	2012
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1 Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Crystallography, X-Ray; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Interferon-alpha; Kinetics; Leucine; Mutagenesis, Site-Directed; Mutation Rate; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Replicon; Thiazoles; Viral Nonstructural Proteins	2012
Interferon-free treatment regimens for hepatitis C: are we there yet? Gastroenterology, 2011, Volume: 141, Issue:6 Topics: Aminoisobutyric Acids; Antiviral Agents; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Oligopeptides; Proline; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; Thiazoles	2011
Baseline hepatitis C virus (HCV) NS3 polymorphisms and their impact on treatment response in clinical studies of the HCV NS3 protease inhibitor faldaprevir. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:2 Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins	2014
Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Drug Stability; Drug Storage; Feces; Female; Hepatocytes; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Leucine; Male; Metabolic Clearance Rate; Microsomes; Oligopeptides; Proline; Protein Binding; Quinolines; Thiazoles	2014
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3 Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Stability; Female; Fibroblasts; Glucuronides; Hepatocytes; Humans; Kinetics; Leucine; Liver; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Organic Anion Transporters; Proline; Quinolines; Sodium; Thiazoles	2014
Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac). Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:3 Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Bile; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Dose-Response Relationship, Drug; Drug Stability; Fibroblasts; Glucuronides; Hepacivirus; Hepatocytes; Leucine; Liver; Male; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Proline; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles	2014
Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Volume: 58, Issue:7 Topics: Aminoisobutyric Acids; Anti-HIV Agents; Antiviral Agents; Carbamates; Developing Countries; Drug Industry; Drug Therapy, Combination; Health Services Accessibility; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine	2014
Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy. Alimentary pharmacology & therapeutics, 2014, Volume: 39, Issue:12 Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Interferons; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate	2014
Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:11 Topics: Administration, Oral; Aminoisobutyric Acids; Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Injections, Intravenous; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles; Urine	2014
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake. HIV medicine, 2015, Volume: 16, Issue:10 Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cohort Studies; Female; Hepatitis C, Chronic; HIV Infections; Humans; Leucine; Male; Middle Aged; Oligopeptides; Patient Acceptance of Health Care; Proline; Prospective Studies; Protease Inhibitors; Quinolines; RNA, Viral; Switzerland; Thiazoles; Viral Load	2015
Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy. Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:6 Topics: Aminoisobutyric Acids; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Polymers; Proline; Quinolines; Spectrometry, Mass, Electrospray Ionization; Thiazoles	2016
Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir. PloS one, 2016, Volume: 11, Issue:8 Topics: Acrylates; Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins	2016
Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir. Molecular bioSystems, 2016, 11-15, Volume: 12, Issue:12 Topics: Amino Acid Substitution; Aminoisobutyric Acids; Binding Sites; Catalytic Domain; Codon; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Humans; Hydrogen Bonding; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Molecular Conformation; Mutation; Oligopeptides; Proline; Protein Binding; Quinolines; Sulfonamides; Thiazoles; Viral Nonstructural Proteins	2016
[Molecular recognition mechanism and motion of HCV NS3/4A protease with Faldaprevir analogue]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2016, May-25, Volume: 32, Issue:5 Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Endopeptidases; Hepacivirus; Intracellular Signaling Peptides and Proteins; Leucine; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Serine Proteases; Thiazoles; Viral Nonstructural Proteins	2016
Effect of itraconazole on the pharmacokinetics of faldaprevir in healthy subjects. Die Pharmazie, 2021, 05-01, Volume: 76, Issue:5 Topics: Adult; Aminoisobutyric Acids; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Leucine; Male; Middle Aged; Proline; Quinolines; Thiazoles	2021