proline has been researched along with alpha-synuclein in 39 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (5.13) | 18.2507 |
2000's | 14 (35.90) | 29.6817 |
2010's | 19 (48.72) | 24.3611 |
2020's | 4 (10.26) | 2.80 |
Authors | Studies |
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Epplen, JT; Graeber, M; Kösel, S; Krüger, R; Kuhn, W; Müller, T; Przuntek, H; Riess, O; Schöls, L; Woitalla, D | 1 |
Crowther, RA; Goedert, M; Jakes, R; Spillantini, MG | 1 |
Conway, KA; Harper, JD; Lansbury, PT | 1 |
Epplen, JT; Krüger, R; Kuhn, W; Leenders, KL; Maguire, RP; Müller, T; Portman, AT; Przuntek, H; Riess, O; Schöls, L; Schröder, U; Sprengelmeyer, R; Veenma, L; Woitalla, D | 1 |
Sidhu, A; Vernier, P; Wersinger, C | 1 |
Bussell, R; Eliezer, D | 1 |
Albasanz, JL; Dalfó, E; Ferrer, I; Martin, M | 1 |
Frasier, M; Haas, C; Kahle, P; Lee, JM; Magnuson, D; McCarthy, L; Walzer, M; Wolozin, B | 1 |
Butterfield, DA; Calabrese, V; Frasier, M; Poon, HF; Shreve, N; Wolozin, B | 1 |
Cabodevilla, F; Catena, S; Cuadrado, M; Dalfó, E; Ferrer, I; Gil-Bea, FJ; Gómez-Isla, T; Nieto, M; Ramírez, MJ; Ribé, E; Sánchez, B; Sesma, T | 1 |
Kobayashi, N; Ochiai, S; Sode, K; Usuzaka, E | 1 |
Chung, KC; Kim, HJ; Kim, J; Lee, CH; Lee, D; Paik, SR | 1 |
Fujitani, N; Hata, A; Kaneko, M; Kubota, K; Matsumura, S; Murahashi, K; Nagashima, K; Nomura, Y; Okuma, Y; Omura, T; Orba, Y; Takahashi, R; Uehara, T | 1 |
Lee, D; Park, SS; Schulz, EM | 1 |
Gureviciene, I; Gurevicius, K; Tanila, H | 1 |
Aigner, R; Burgmayer, R; Couillard-Despres, S; Kandasamy, M; Klucken, J; Marxreiter, F; Nuber, S; Riess, O; Winkler, J; Winner, B | 1 |
Bax, A; Bodner, CR; Dobson, CM; Maltsev, AS | 1 |
Bornemann, A; Deller, T; Den Dunnen, WF; Dickson, D; Gai, WP; Gierga, K; Krüger, R; Nuber, S; Petrasch-Parwez, E; Rami, A; Riess, O; Rüb, U; Schöls, L; Seidel, K; Wszolek, Z | 1 |
Baekelandt, V; Desender, L; Engelborghs, Y; Gerard, M; Meuvis, J | 1 |
Gerhardt, E; Kermer, P; Outeiro, TF; Szego, ÉM | 1 |
Baekelandt, V; García-Horsman, JA; Gerard, M; Hannula, MJ; Lambeir, AM; Männistö, PT; Myöhänen, TT; Van Der Veken, P; Van Elzen, R | 1 |
Aloglu, AK; Coskuner, O; Dunn, A; Sakallioglu, IT; Wise-Scira, O | 1 |
Esmer, H; Ettle, B; Klucken, J; Kragh, CL; Marxreiter, F; Masliah, E; May, VE; Nuber, S; Patrick, C; Riess, O; Winkler, J; Winner, B | 1 |
Becker, S; Bibow, S; Biernat, J; Blackledge, M; Gajda, M; Jaremko, L; Jaremko, M; Jensen, MR; Mandelkow, E; Ozenne, V; Schwalbe, M; Zweckstetter, M | 1 |
Harvey, BK; Maguire-Zeiss, KA; Männistö, PT; Myöhänen, TT; Richie, CT; Savolainen, MH | 1 |
Bahr, BA | 1 |
Dokleja, L; Hannula, MJ; Myöhänen, TT | 1 |
Huttunen, HJ; Myöhänen, TT; Savolainen, MH; Yan, X | 1 |
Myöhänen, TT; Norrbacka, S; Savolainen, MH | 1 |
Julku, UH; Myöhänen, TT; Svarcbahs, R | 1 |
Deangeli, G; Di Monte, DA; Migdalska-Richards, A; Rusconi, R; Schapira, AHV; Spillantini, MG; Wegrzynowicz, M | 1 |
Alderson, TR; Bax, A; Charlier, C; Lee, JH; Ying, J | 1 |
Becker, S; Griesinger, C; Maier, J; Wienands, J; Wong, LE | 1 |
Funayama, M; Hattori, N; Li, Y; Matsuura, E; Nishioka, K; Takanashi, M; Takashima, H; Tsuyama, S; Yoshino, H | 1 |
Julku, UH; Kilpeläinen, T; Myöhänen, TT; Svarcbahs, R | 1 |
Andreas, LB; Baker, JD; Becker, S; Blair, LJ; Favretto, F; Strohäker, T; Zweckstetter, M | 1 |
Hellinen, L; Huttunen, H; Kilpeläinen, TP; Lambeir, AM; Myöhänen, TT; Svarcbahs, R; Urtti, A; Vellonen, KS; Vrijdag, J; Wallen, EAA; Yan, X | 1 |
Cui, H; Erlandsson, A; Falk, A; Jäntti, M; Kukkonen, JP; Myöhänen, T; Rinne, MK; Rostami, J | 1 |
Andreas, LB; Baker, JD; Becker, S; Blair, LJ; Favretto, F; Flores, D; Strohäker, T; Zweckstetter, M | 1 |
39 other study(ies) available for proline and alpha-synuclein
Article | Year |
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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Base Sequence; Female; Humans; Male; Nerve Tissue Proteins; Parkinson Disease; Pedigree; Point Mutation; Polymorphism, Single-Stranded Conformational; Proline; Synucleins | 1998 |
Synthetic filaments assembled from C-terminally truncated alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Cloning, Molecular; Humans; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Open Reading Frames; Phosphoproteins; Point Mutation; Proline; Recombinant Proteins; Sequence Deletion; Synucleins; Threonine | 1998 |
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine | 2000 |
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.
Topics: Aged; Alanine; alpha-Synuclein; Amino Acid Sequence; Apolipoproteins E; Brain; DNA Mutational Analysis; Female; Genotype; Germany; Humans; Male; Middle Aged; Mutation; Nerve Tissue Proteins; Neuropsychological Tests; Parkinsonian Disorders; Pedigree; Proline; Synucleins; Thiolester Hydrolases; Tomography, Emission-Computed; Ubiquitin Thiolesterase | 2001 |
Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant.
Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Biotinylation; Cell Death; Cell Line; Cell Line, Tumor; Cells, Cultured; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Proline; Protein Transport; Rats; Synucleins; Transfection; Trypsin | 2004 |
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Humans; Lipid Metabolism; Liposomes; Micelles; Mutation, Missense; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Phosphatidic Acids; Phosphatidylcholines; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Threonine | 2004 |
Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Cell Fractionation; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Guanosine Triphosphate; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Lewy Body Disease; Male; Membrane Proteins; Microscopy, Confocal; Middle Aged; Nerve Tissue Proteins; Postmortem Changes; Proline; Propionates; Protein Binding; Quisqualic Acid; Radioligand Assay; Receptors, Glutamate; Signal Transduction; Synaptosomal-Associated Protein 25; Synucleins; Tritium; Type C Phospholipases | 2004 |
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Topics: Age Factors; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Movement Disorders; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Proline; Synucleins; tau Proteins | 2005 |
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.
Topics: Alanine; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Energy Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Proline; Synucleins | 2005 |
Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Alanine; alpha-Synuclein; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Insecticides; Mice; Mice, Transgenic; Neurons; Neurotoxins; Proline; Rotenone; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Amyloid; Bone Marrow Cells; Circular Dichroism; DNA; DNA, Complementary; Gene Library; Humans; Light; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Parkinson Disease; Peptides; Polymerase Chain Reaction; Proline; Protein Binding; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Scattering, Radiation; Synucleins; Time Factors; Ubiquitin-Protein Ligases; Ultraviolet Rays; Valine | 2005 |
Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasome.
Topics: alpha-Synuclein; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Animals; Calpain; Electrophoresis, Polyacrylamide Gel; Glutamates; Hydrolysis; Models, Biological; Molecular Sequence Data; Mutation; Proline; Proteasome Endopeptidase Complex; Serine; Substrate Specificity; Swine; Threonine | 2006 |
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
Topics: alpha-Synuclein; Animals; Blotting, Western; Cell Death; Cell Line; Dopamine; Endoplasmic Reticulum; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Transgenic; Models, Biological; Mutagenesis; Neurons; Phosphopyruvate Hydratase; Proline; Protein Binding; Receptors, G-Protein-Coupled; RNA Interference; Substantia Nigra; Ubiquitin-Protein Ligases | 2006 |
Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.
Topics: Alanine; alpha-Methyltyrosine; alpha-Synuclein; Animals; Animals, Genetically Modified; Cells, Cultured; Dopamine; Drosophila; Embryo, Nonmammalian; Enzyme Inhibitors; Glutathione; Green Fluorescent Proteins; Homeostasis; Humans; Indoles; Mutation; Nerve Degeneration; Proline; Receptors, Dopamine D1; Time Factors; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2007 |
Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus.
Topics: Aging; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Dentate Gyrus; Electric Stimulation; Escape Reaction; Excitatory Postsynaptic Potentials; Humans; Locomotion; Mice; Mice, Transgenic; Mutation; Neuronal Plasticity; Perforant Pathway; Proline; Reaction Time; Synapses; Time Factors | 2009 |
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Proliferation; Doublecortin Domain Proteins; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Neurogenesis; Neurons; Neuropeptides; Olfactory Bulb; Proliferating Cell Nuclear Antigen; Proline | 2009 |
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.
Topics: Alanine; alpha-Synuclein; Genetic Variation; Glutamic Acid; Humans; Lysine; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Parkinson Disease; Peptide Fragments; Phospholipids; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Solutions; Threonine | 2010 |
First appraisal of brain pathology owing to A30P mutant alpha-synuclein.
Topics: Aged; Alanine; alpha-Synuclein; Brain; Brain Diseases; Family Health; Glial Fibrillary Acidic Protein; Humans; Inclusion Bodies; Male; Mutation; Proline | 2010 |
The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region.
Topics: alpha-Synuclein; Humans; Kinetics; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Multimerization; Tacrolimus Binding Protein 1A | 2010 |
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.
Topics: Acetylcholinesterase; Alanine; alpha-Synuclein; Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Dopamine; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; MPTP Poisoning; Mutation; Neurons; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, trkB; Time Factors | 2011 |
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Blotting, Western; Brain; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Motor Activity; Oxidative Stress; Parkinsonian Disorders; Proline; Prolyl Oligopeptidases; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases; Serine Proteinase Inhibitors; Transfection | 2012 |
Structures and free energy landscapes of the wild-type and A30P mutant-type α-synuclein proteins with dynamics.
Topics: Alanine; alpha-Synuclein; Energy Metabolism; Humans; Molecular Dynamics Simulation; Mutant Proteins; Mutation, Missense; Proline; Protein Structure, Secondary; Protein Structure, Tertiary | 2013 |
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.
Topics: Alanine; alpha-Synuclein; Animals; Anxiety; Avoidance Learning; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Doxycycline; Gene Expression Regulation; Hippocampus; Humans; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurogenesis; Neuroglia; Neuropeptides; Olfactory Bulb; Proline | 2013 |
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.
Topics: Algorithms; alpha-Synuclein; Humans; Intrinsically Disordered Proteins; Magnetic Resonance Spectroscopy; Membrane Proteins; Neurodegenerative Diseases; Proline; Protein Folding; Protein Structure, Tertiary; Scattering, Radiation | 2014 |
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
Topics: Alanine; alpha-Synuclein; Animals; Autophagy; Brain; Brain Diseases; Cell Line, Transformed; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Time Factors | 2014 |
A single pathway targets several health challenges of the elderly.
Topics: alpha-Synuclein; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain Diseases; Humans; Membrane Proteins; Peptide Fragments; Proline; Serine Endopeptidases; Serine Proteinase Inhibitors | 2014 |
Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers.
Topics: alpha-Synuclein; Autophagy; Cell Line, Tumor; Humans; Mitochondria; Mutation; Proline; Prolyl Oligopeptidases; Protein Aggregates; Reactive Oxygen Species; Rotenone; Serine Endopeptidases; Serine Proteinase Inhibitors; Solubility | 2014 |
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Autophagy; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Mice; Mutation, Missense; Parkinson Disease; Proline; Prolyl Oligopeptidases; Protein Multimerization; Protein Structure, Tertiary; Serine Endopeptidases | 2015 |
Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture.
Topics: Acetylcysteine; alpha-Synuclein; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Mutation; Proline; Prolyl Oligopeptidases; Proteasome Inhibitors; Protein Aggregates; Serine Endopeptidases; Serine Proteinase Inhibitors | 2017 |
Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain.
Topics: alpha-Synuclein; Animals; Brain Chemistry; Endopeptidase K; Forelimb; Genetic Vectors; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neural Pathways; Parkinson Disease; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Serine Endopeptidases; Tyrosine 3-Monooxygenase | 2016 |
The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice.
Topics: Age Factors; alpha-Synuclein; Animals; beta-N-Acetylhexosaminidases; Brain; Dopamine; Glucosylceramidase; Humans; Leucine; Mice; Mice, Transgenic; Mutation; Neurons; Proline; Psychomotor Performance; Smell; Substantia Nigra; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2017 |
Propensity for cis-Proline Formation in Unfolded Proteins.
Topics: alpha-Synuclein; Isomerism; Nuclear Magnetic Resonance, Biomolecular; Pressure; Proline; Protein Denaturation | 2018 |
Sensitivity-Enhanced Four-Dimensional Amide-Amide Correlation NMR Experiments for Sequential Assignment of Proline-Rich Disordered Proteins.
Topics: Adaptor Proteins, Signal Transducing; alpha-Synuclein; Amides; Humans; Nuclear Magnetic Resonance, Biomolecular; Proline | 2018 |
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.
Topics: Aged; alpha-Synuclein; Astrocytes; Autopsy; DNA-Binding Proteins; Female; Gene Expression Regulation; Histidine; Homozygote; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Neurodegenerative Diseases; Parkinsonian Disorders; Proline; Protein Aggregation, Pathological; Substantia Nigra; tau Proteins | 2018 |
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
Topics: Aging; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parkinson Disease; Proline; Threonine | 2019 |
The Molecular Basis of the Interaction of Cyclophilin A with α-Synuclein.
Topics: alpha-Synuclein; Amino Acid Sequence; Binding Sites; Biocatalysis; Crystallography, X-Ray; Cyclophilin A; Isomerism; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Proline; Protein Binding | 2020 |
The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy.
Topics: alpha-Synuclein; Antiparkinson Agents; Autophagy; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Microtubule-Associated Proteins; Proline; Prolyl Oligopeptidases; Protein Aggregates; Protein Multimerization; Serine Proteinase Inhibitors | 2020 |
Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells.
Topics: alpha-Synuclein; Astrocytes; Autophagy; Cell Line, Tumor; Cells, Cultured; Disease Progression; Humans; Neurons; Parkinson Disease; Proline; Prolyl Oligopeptidases; Serine Proteinase Inhibitors | 2020 |
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war.
Topics: alpha-Synuclein; Amyloid; Catalysis; Cyclophilin A; Cyclosporine; Humans; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Chaperones; Parkinson Disease; Proline; Protein Aggregates; Protein Binding; Protein Domains | 2020 |