proline and alpha-synuclein

proline has been researched along with alpha-synuclein in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (5.13)	18.2507
2000's	14 (35.90)	29.6817
2010's	19 (48.72)	24.3611
2020's	4 (10.26)	2.80

Authors

Authors	Studies
Epplen, JT; Graeber, M; Kösel, S; Krüger, R; Kuhn, W; Müller, T; Przuntek, H; Riess, O; Schöls, L; Woitalla, D	1
Crowther, RA; Goedert, M; Jakes, R; Spillantini, MG	1
Conway, KA; Harper, JD; Lansbury, PT	1
Epplen, JT; Krüger, R; Kuhn, W; Leenders, KL; Maguire, RP; Müller, T; Portman, AT; Przuntek, H; Riess, O; Schöls, L; Schröder, U; Sprengelmeyer, R; Veenma, L; Woitalla, D	1
Sidhu, A; Vernier, P; Wersinger, C	1
Bussell, R; Eliezer, D	1
Albasanz, JL; Dalfó, E; Ferrer, I; Martin, M	1
Frasier, M; Haas, C; Kahle, P; Lee, JM; Magnuson, D; McCarthy, L; Walzer, M; Wolozin, B	1
Butterfield, DA; Calabrese, V; Frasier, M; Poon, HF; Shreve, N; Wolozin, B	1
Cabodevilla, F; Catena, S; Cuadrado, M; Dalfó, E; Ferrer, I; Gil-Bea, FJ; Gómez-Isla, T; Nieto, M; Ramírez, MJ; Ribé, E; Sánchez, B; Sesma, T	1
Kobayashi, N; Ochiai, S; Sode, K; Usuzaka, E	1
Chung, KC; Kim, HJ; Kim, J; Lee, CH; Lee, D; Paik, SR	1
Fujitani, N; Hata, A; Kaneko, M; Kubota, K; Matsumura, S; Murahashi, K; Nagashima, K; Nomura, Y; Okuma, Y; Omura, T; Orba, Y; Takahashi, R; Uehara, T	1
Lee, D; Park, SS; Schulz, EM	1
Gureviciene, I; Gurevicius, K; Tanila, H	1
Aigner, R; Burgmayer, R; Couillard-Despres, S; Kandasamy, M; Klucken, J; Marxreiter, F; Nuber, S; Riess, O; Winkler, J; Winner, B	1
Bax, A; Bodner, CR; Dobson, CM; Maltsev, AS	1
Bornemann, A; Deller, T; Den Dunnen, WF; Dickson, D; Gai, WP; Gierga, K; Krüger, R; Nuber, S; Petrasch-Parwez, E; Rami, A; Riess, O; Rüb, U; Schöls, L; Seidel, K; Wszolek, Z	1
Baekelandt, V; Desender, L; Engelborghs, Y; Gerard, M; Meuvis, J	1
Gerhardt, E; Kermer, P; Outeiro, TF; Szego, ÉM	1
Baekelandt, V; García-Horsman, JA; Gerard, M; Hannula, MJ; Lambeir, AM; Männistö, PT; Myöhänen, TT; Van Der Veken, P; Van Elzen, R	1
Aloglu, AK; Coskuner, O; Dunn, A; Sakallioglu, IT; Wise-Scira, O	1
Esmer, H; Ettle, B; Klucken, J; Kragh, CL; Marxreiter, F; Masliah, E; May, VE; Nuber, S; Patrick, C; Riess, O; Winkler, J; Winner, B	1
Becker, S; Bibow, S; Biernat, J; Blackledge, M; Gajda, M; Jaremko, L; Jaremko, M; Jensen, MR; Mandelkow, E; Ozenne, V; Schwalbe, M; Zweckstetter, M	1
Harvey, BK; Maguire-Zeiss, KA; Männistö, PT; Myöhänen, TT; Richie, CT; Savolainen, MH	1
Bahr, BA	1
Dokleja, L; Hannula, MJ; Myöhänen, TT	1
Huttunen, HJ; Myöhänen, TT; Savolainen, MH; Yan, X	1
Myöhänen, TT; Norrbacka, S; Savolainen, MH	1
Julku, UH; Myöhänen, TT; Svarcbahs, R	1
Deangeli, G; Di Monte, DA; Migdalska-Richards, A; Rusconi, R; Schapira, AHV; Spillantini, MG; Wegrzynowicz, M	1
Alderson, TR; Bax, A; Charlier, C; Lee, JH; Ying, J	1
Becker, S; Griesinger, C; Maier, J; Wienands, J; Wong, LE	1
Funayama, M; Hattori, N; Li, Y; Matsuura, E; Nishioka, K; Takanashi, M; Takashima, H; Tsuyama, S; Yoshino, H	1
Julku, UH; Kilpeläinen, T; Myöhänen, TT; Svarcbahs, R	1
Andreas, LB; Baker, JD; Becker, S; Blair, LJ; Favretto, F; Strohäker, T; Zweckstetter, M	1
Hellinen, L; Huttunen, H; Kilpeläinen, TP; Lambeir, AM; Myöhänen, TT; Svarcbahs, R; Urtti, A; Vellonen, KS; Vrijdag, J; Wallen, EAA; Yan, X	1
Cui, H; Erlandsson, A; Falk, A; Jäntti, M; Kukkonen, JP; Myöhänen, T; Rinne, MK; Rostami, J	1
Andreas, LB; Baker, JD; Becker, S; Blair, LJ; Favretto, F; Flores, D; Strohäker, T; Zweckstetter, M	1

Other Studies

39 other study(ies) available for proline and alpha-synuclein

Article	Year
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nature genetics, 1998, Volume: 18, Issue:2 Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Base Sequence; Female; Humans; Male; Nerve Tissue Proteins; Parkinson Disease; Pedigree; Point Mutation; Polymorphism, Single-Stranded Conformational; Proline; Synucleins	1998
Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS letters, 1998, Oct-09, Volume: 436, Issue:3 Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Cloning, Molecular; Humans; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Open Reading Frames; Phosphoproteins; Point Mutation; Proline; Recombinant Proteins; Sequence Deletion; Synucleins; Threonine	1998
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry, 2000, Mar-14, Volume: 39, Issue:10 Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine	2000
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers. Neurology, 2001, May-22, Volume: 56, Issue:10 Topics: Aged; Alanine; alpha-Synuclein; Amino Acid Sequence; Apolipoproteins E; Brain; DNA Mutational Analysis; Female; Genotype; Germany; Humans; Male; Middle Aged; Mutation; Nerve Tissue Proteins; Neuropsychological Tests; Parkinsonian Disorders; Pedigree; Proline; Synucleins; Thiolester Hydrolases; Tomography, Emission-Computed; Ubiquitin Thiolesterase	2001
Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant. Biochemistry, 2004, Feb-10, Volume: 43, Issue:5 Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Biotinylation; Cell Death; Cell Line; Cell Line, Tumor; Cells, Cultured; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Proline; Protein Transport; Rats; Synucleins; Transfection; Trypsin	2004
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry, 2004, Apr-27, Volume: 43, Issue:16 Topics: Alanine; alpha-Synuclein; Humans; Lipid Metabolism; Liposomes; Micelles; Mutation, Missense; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Phosphatidic Acids; Phosphatidylcholines; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Threonine	2004
Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions. Brain pathology (Zurich, Switzerland), 2004, Volume: 14, Issue:4 Topics: Aged; Aged, 80 and over; alpha-Synuclein; Cell Fractionation; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Guanosine Triphosphate; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Lewy Body Disease; Male; Membrane Proteins; Microscopy, Confocal; Middle Aged; Nerve Tissue Proteins; Postmortem Changes; Proline; Propionates; Protein Binding; Quisqualic Acid; Radioligand Assay; Receptors, Glutamate; Signal Transduction; Synaptosomal-Associated Protein 25; Synucleins; Tritium; Type C Phospholipases	2004
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Experimental neurology, 2005, Volume: 192, Issue:2 Topics: Age Factors; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Movement Disorders; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphorylation; Proline; Synucleins; tau Proteins	2005
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease. Neurobiology of disease, 2005, Volume: 18, Issue:3 Topics: Alanine; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Energy Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Proline; Synucleins	2005
Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice. Neurobiology of aging, 2006, Volume: 27, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Alanine; alpha-Synuclein; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Insecticides; Mice; Mice, Transgenic; Neurons; Neurotoxins; Proline; Rotenone; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase	2006
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation. Biochemical and biophysical research communications, 2005, Sep-23, Volume: 335, Issue:2 Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Amyloid; Bone Marrow Cells; Circular Dichroism; DNA; DNA, Complementary; Gene Library; Humans; Light; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Parkinson Disease; Peptides; Polymerase Chain Reaction; Proline; Protein Binding; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Scattering, Radiation; Synucleins; Time Factors; Ubiquitin-Protein Ligases; Ultraviolet Rays; Valine	2005
Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasome. Archives of biochemistry and biophysics, 2006, Nov-01, Volume: 455, Issue:1 Topics: alpha-Synuclein; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Animals; Calpain; Electrophoresis, Polyacrylamide Gel; Glutamates; Hydrolysis; Models, Biological; Molecular Sequence Data; Mutation; Proline; Proteasome Endopeptidase Complex; Serine; Substrate Specificity; Swine; Threonine	2006
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. Journal of neurochemistry, 2006, Volume: 99, Issue:6 Topics: alpha-Synuclein; Animals; Blotting, Western; Cell Death; Cell Line; Dopamine; Endoplasmic Reticulum; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Transgenic; Models, Biological; Mutagenesis; Neurons; Phosphopyruvate Hydratase; Proline; Protein Binding; Receptors, G-Protein-Coupled; RNA Interference; Substantia Nigra; Ubiquitin-Protein Ligases	2006
Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein. The European journal of neuroscience, 2007, Volume: 26, Issue:11 Topics: Alanine; alpha-Methyltyrosine; alpha-Synuclein; Animals; Animals, Genetically Modified; Cells, Cultured; Dopamine; Drosophila; Embryo, Nonmammalian; Enzyme Inhibitors; Glutathione; Green Fluorescent Proteins; Homeostasis; Humans; Indoles; Mutation; Nerve Degeneration; Proline; Receptors, Dopamine D1; Time Factors; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins	2007
Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus. Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:1 Topics: Aging; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Dentate Gyrus; Electric Stimulation; Escape Reaction; Excitatory Postsynaptic Potentials; Humans; Locomotion; Mice; Mice, Transgenic; Mutation; Neuronal Plasticity; Perforant Pathway; Proline; Reaction Time; Synapses; Time Factors	2009
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. The European journal of neuroscience, 2009, Volume: 29, Issue:5 Topics: Alanine; alpha-Synuclein; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Proliferation; Doublecortin Domain Proteins; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Neurogenesis; Neurons; Neuropeptides; Olfactory Bulb; Proliferating Cell Nuclear Antigen; Proline	2009
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry, 2010, Feb-09, Volume: 49, Issue:5 Topics: Alanine; alpha-Synuclein; Genetic Variation; Glutamic Acid; Humans; Lysine; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Parkinson Disease; Peptide Fragments; Phospholipids; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Solutions; Threonine	2010
First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Annals of neurology, 2010, Volume: 67, Issue:5 Topics: Aged; Alanine; alpha-Synuclein; Brain; Brain Diseases; Family Health; Glial Fibrillary Acidic Protein; Humans; Inclusion Bodies; Male; Mutation; Proline	2010
The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region. Biochemistry, 2010, Nov-02, Volume: 49, Issue:43 Topics: alpha-Synuclein; Humans; Kinetics; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Multimerization; Tacrolimus Binding Protein 1A	2010
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice. Journal of the neurological sciences, 2011, Nov-15, Volume: 310, Issue:1-2 Topics: Acetylcholinesterase; Alanine; alpha-Synuclein; Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Dopamine; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; MPTP Poisoning; Mutation; Neurons; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, trkB; Time Factors	2011
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. British journal of pharmacology, 2012, Volume: 166, Issue:3 Topics: alpha-Synuclein; Animals; Blotting, Western; Brain; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Motor Activity; Oxidative Stress; Parkinsonian Disorders; Proline; Prolyl Oligopeptidases; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases; Serine Proteinase Inhibitors; Transfection	2012
Structures and free energy landscapes of the wild-type and A30P mutant-type α-synuclein proteins with dynamics. ACS chemical neuroscience, 2013, Mar-20, Volume: 4, Issue:3 Topics: Alanine; alpha-Synuclein; Energy Metabolism; Humans; Molecular Dynamics Simulation; Mutant Proteins; Mutation, Missense; Proline; Protein Structure, Secondary; Protein Structure, Tertiary	2013
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiology of disease, 2013, Volume: 59 Topics: Alanine; alpha-Synuclein; Animals; Anxiety; Avoidance Learning; Cell Count; Disease Models, Animal; Doublecortin Domain Proteins; Doxycycline; Gene Expression Regulation; Hippocampus; Humans; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurogenesis; Neuroglia; Neuropeptides; Olfactory Bulb; Proline	2013
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering. Structure (London, England : 1993), 2014, Feb-04, Volume: 22, Issue:2 Topics: Algorithms; alpha-Synuclein; Humans; Intrinsically Disordered Proteins; Magnetic Resonance Spectroscopy; Membrane Proteins; Neurodegenerative Diseases; Proline; Protein Folding; Protein Structure, Tertiary; Scattering, Radiation	2014
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. Neurobiology of disease, 2014, Volume: 68 Topics: Alanine; alpha-Synuclein; Animals; Autophagy; Brain; Brain Diseases; Cell Line, Transformed; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Proline; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Time Factors	2014
A single pathway targets several health challenges of the elderly. Rejuvenation research, 2014, Volume: 17, Issue:4 Topics: alpha-Synuclein; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain Diseases; Humans; Membrane Proteins; Peptide Fragments; Proline; Serine Endopeptidases; Serine Proteinase Inhibitors	2014
Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers. Neuroscience letters, 2014, Nov-07, Volume: 583 Topics: alpha-Synuclein; Autophagy; Cell Line, Tumor; Humans; Mitochondria; Mutation; Proline; Prolyl Oligopeptidases; Protein Aggregates; Reactive Oxygen Species; Rotenone; Serine Endopeptidases; Serine Proteinase Inhibitors; Solubility	2014
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction. The Journal of biological chemistry, 2015, Feb-20, Volume: 290, Issue:8 Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Autophagy; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Mice; Mutation, Missense; Parkinson Disease; Proline; Prolyl Oligopeptidases; Protein Multimerization; Protein Structure, Tertiary; Serine Endopeptidases	2015
Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture. Neuroscience letters, 2017, 01-01, Volume: 636 Topics: Acetylcysteine; alpha-Synuclein; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Mutation; Proline; Prolyl Oligopeptidases; Proteasome Inhibitors; Protein Aggregates; Serine Endopeptidases; Serine Proteinase Inhibitors	2017
Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 12-07, Volume: 36, Issue:49 Topics: alpha-Synuclein; Animals; Brain Chemistry; Endopeptidase K; Forelimb; Genetic Vectors; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neural Pathways; Parkinson Disease; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Serine Endopeptidases; Tyrosine 3-Monooxygenase	2016
The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice. Brain : a journal of neurology, 2017, Oct-01, Volume: 140, Issue:10 Topics: Age Factors; alpha-Synuclein; Animals; beta-N-Acetylhexosaminidases; Brain; Dopamine; Glucosylceramidase; Humans; Leucine; Mice; Mice, Transgenic; Mutation; Neurons; Proline; Psychomotor Performance; Smell; Substantia Nigra; Transduction, Genetic; Tyrosine 3-Monooxygenase	2017
Propensity for cis-Proline Formation in Unfolded Proteins. Chembiochem : a European journal of chemical biology, 2018, 01-04, Volume: 19, Issue:1 Topics: alpha-Synuclein; Isomerism; Nuclear Magnetic Resonance, Biomolecular; Pressure; Proline; Protein Denaturation	2018
Sensitivity-Enhanced Four-Dimensional Amide-Amide Correlation NMR Experiments for Sequential Assignment of Proline-Rich Disordered Proteins. Journal of the American Chemical Society, 2018, 03-14, Volume: 140, Issue:10 Topics: Adaptor Proteins, Signal Transducing; alpha-Synuclein; Amides; Humans; Nuclear Magnetic Resonance, Biomolecular; Proline	2018
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations. Acta neuropathologica communications, 2018, 10-17, Volume: 6, Issue:1 Topics: Aged; alpha-Synuclein; Astrocytes; Autopsy; DNA-Binding Proteins; Female; Gene Expression Regulation; Histidine; Homozygote; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Neurodegenerative Diseases; Parkinsonian Disorders; Proline; Protein Aggregation, Pathological; Substantia Nigra; tau Proteins	2018
Behavioural and dopaminergic changes in double mutated human A30PA53T alpha-synuclein transgenic mouse model of Parkinson´s disease. Scientific reports, 2019, 11-22, Volume: 9, Issue:1* Topics: Aging; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parkinson Disease; Proline; Threonine	2019
The Molecular Basis of the Interaction of Cyclophilin A with α-Synuclein. Angewandte Chemie (International ed. in English), 2020, 03-27, Volume: 59, Issue:14 Topics: alpha-Synuclein; Amino Acid Sequence; Binding Sites; Biocatalysis; Crystallography, X-Ray; Cyclophilin A; Isomerism; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Proline; Protein Binding	2020
The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128 Topics: alpha-Synuclein; Antiparkinson Agents; Autophagy; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Microtubule-Associated Proteins; Proline; Prolyl Oligopeptidases; Protein Aggregates; Protein Multimerization; Serine Proteinase Inhibitors	2020
Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131 Topics: alpha-Synuclein; Astrocytes; Autophagy; Cell Line, Tumor; Cells, Cultured; Disease Progression; Humans; Neurons; Parkinson Disease; Proline; Prolyl Oligopeptidases; Serine Proteinase Inhibitors	2020
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature communications, 2020, 11-27, Volume: 11, Issue:1 Topics: alpha-Synuclein; Amyloid; Catalysis; Cyclophilin A; Cyclosporine; Humans; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Chaperones; Parkinson Disease; Proline; Protein Aggregates; Protein Binding; Protein Domains	2020