proline and 4-aminopyrrolidine-2,4-dicarboxylic acid

proline has been researched along with 4-aminopyrrolidine-2,4-dicarboxylic acid in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (24.53)	18.2507
2000's	29 (54.72)	29.6817
2010's	11 (20.75)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Burnett, JP; Desai, MA; Johnson, BG; Mayne, NG; Monn, JA; Salhoff, CR; Schoepp, DD; Valli, MJ	1
Bond, A; Campbell, JB; Griffey, K; Howe, T; Johnson, BG; Lodge, D; Monn, JA; Paschal, JW; Salhoff, CR; Schoepp, DD; Spangle, LA; Tizzano, JP; Valli, MJ; Wright, RA	1
Belagaje, R; Burnett, JP; Johnson, BG; Mayne, NG; Monn, JA; Salhoff, CR; Schoepp, DD; Wright, RA; Wu, S	1
Carnuccio, R; D'Acquisto, F; Di Rosa, M; Iuvone, T; Rombolà, L; Sautebin, L	1
Salt, TE; Turner, JP	1
Battaglia, G; Bruno, V; Copani, A; Di Grezia, R; Ngomba, RT; Nicoletti, F	1
Johnson, BG; Kingston, AE; Monn, JA; Schoepp, DD; Tomlinson, R; Valli, MJ; Wright, RA	1
Beaver, CJ; Daw, NW; Ji, Q	1
Casabona, G; De Paolis, P; Lucchi, R; Nicoletti, F; Notari, S; Poli, A; Storto, M	1
Battaglia, G; Bruno, V; Caciagli, F; Ciccarelli, R; D'Alimonte, I; D'Onofrio, M; Di Iorio, P; Nicoletti, F	1
Nishi, N	1
Beart, PM; Jones, NM; Monn, JA; Widdop, RE	1
Hanania, T; Johnson, KM	1
Cahill, CM; Coderre, TJ; Fisher, K; Lefebvre, C	1
Daw, NW; Flavin, HJ; Jin, XT	1
Beart, PM; Chapman, AG; Meldrum, BS; Moldrich, RX; Talebi, A	1
Abraini, JH; David, HN	2
Folbergrová, J; Haugvicová, R; Mares, P	1
Hulsebosch, CE; Johnson, KM; Mills, CD	1
Gereau, RW; Yang, D	1
Chen, WP; Kirchgessner, AL	1
Jankovic, SM; Milovanovic, DR	1
Davies, R; Reynolds, AM; Robbins, J; Treseder, S	1
Battaglia, G; Beraudi, A; Cappuccio, I; Caricasole, A; D'Onofrio, M; Di Giorgi Gerevini, V; Nicoletti, F; Poli, A; Storto, M; Villani, L	1
Russell, JW; Spillson, AB	1
Gregory, ML; Kalivas, PW; Owens, RW; Stech, NE	1
Kalivas, PW; Tang, XC	1
Arpadjan, S; Karadjova, I; Stafilov, T; Todorovska, N	1
Albasanz, JL; Dalfó, E; Ferrer, I; Martin, M	1
Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J	1
Abeniyi, OA; Conn, PJ; Poisik, O; Raju, DV; Rodriguez, A; Smith, Y; Verreault, M	1
Browning, KN; Gettys, TW; Travagli, RA; Zheng, Z	1
de Lange, RP; Graveland, H; Stam, R; Verhave, PS; Wiegant, VM	1
Cahusac, PM; Wan, H	1
Chi, ZF; Feng, YB; Gao, J; Pang, ZY; Yao, H	1
Browning, KN; Travagli, RA	1
Bai, ZT; Chai, ZF; Ji, YH; Jiang, F; Liu, T; Pang, XY	1
Steketee, JD; Xie, X	1
Carlton, SM; Du, J; Zhou, S	1
Druga, R; Folbergrová, J; Haugvicová, R; Otáhal, J; Tsenov, G	1
Feng, Y; Li, H; Shi, J; Sun, ZS; Zhang, J; Zhang, T	1
Kamei, C; Masuoka, T; Mikami, A	1
Lee, HG; Park, SK; Yoon, MH	1
Chi, LY; Chi, ZF; Feng, YB; Man, X; Yao, H	1
Beller, JA; Berman, RF; Gurkoff, GG; Lyeth, BG	1
Druga, R; Folbergrová, J; Otáhal, J	1
Broad, LM; Colvin, EM; Findlay, JD; Grubisha, O; Hanna, L; Heinz, BA; Lodge, D; Monn, JA; Sanger, H; Sher, E; Ursu, D; Vivier, RG	1
Cho, HY; Han, HC; Kim, YI; Lee, KS; Park, EH	1
Cho, DH; Hur, DY; Kim, D; Kim, S; Kim, YS; Lee, HK; Lee, WJ; Park, GB	1
McIlwrath, SL; Westlund, KN	1
Feng, YB; Liu, XP; Pang, YJ; Xu, JJ; Yao, H; Yu, BX	1
Feng, YB; Han, YX; Lin, YT; Pang, YJ; Xu, JJ; Xue, Y; Yao, H	1

Other Studies

53 other study(ies) available for proline and 4-aminopyrrolidine-2,4-dicarboxylic acid

Article	Year
Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate. Neuropharmacology, 1995, Volume: 34, Issue:8 Topics: Animals; Animals, Newborn; Cloning, Molecular; Colforsin; Cyclic AMP; Excitatory Amino Acid Agonists; Female; GTP-Binding Proteins; Hippocampus; Humans; In Vitro Techniques; Male; Norepinephrine; Phosphatidylinositols; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Second Messenger Systems	1995
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. Journal of medicinal chemistry, 1996, Jul-19, Volume: 39, Issue:15 Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Colforsin; Cyclic AMP; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Hydrogen Bonding; Limbic System; Mice; Models, Molecular; Molecular Structure; Proline; Rats; Receptors, Metabotropic Glutamate; Seizures; Spinal Cord; Stereoisomerism	1996
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors. Neuropharmacology, 1996, Volume: 35, Issue:12 Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Inositol; Kinetics; Neuroprotective Agents; Phosphatidylinositols; Proline; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Second Messenger Systems	1996
Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS letters, 1997, Nov-24, Volume: 418, Issue:1-2 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cell Line; Cell Nucleus; Cyclooxygenase 2; Cytosol; Dinoprostone; Gene Expression Regulation, Enzymologic; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; NF-kappa B; Proline; Prostaglandin-Endoperoxide Synthases; Tosyllysine Chloromethyl Ketone	1997
Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate. Experimental brain research, 1998, Volume: 121, Issue:2 Topics: Animals; Excitatory Amino Acid Agonists; Iontophoresis; Male; Neural Inhibition; Neurons, Afferent; Physical Stimulation; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sensation; Thalamus; Vibrissae	1998
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death. European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3 Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Nerve Degeneration; Proline; Receptors, Metabotropic Glutamate	1998
Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid. Bioorganic & medicinal chemistry letters, 1998, Aug-04, Volume: 8, Issue:15 Topics: Humans; Hydrolysis; Phosphatidylinositol Phosphates; Proline; Receptors, Metabotropic Glutamate; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship	1998
Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex. Journal of neurophysiology, 1999, Volume: 82, Issue:1 Topics: Aging; Animals; Cats; Darkness; Excitatory Amino Acid Agonists; Light; Neurons; Proline; Reaction Time; Receptors, Metabotropic Glutamate; Visual Cortex; Visual Perception	1999
Predominant expression of group-II metabotropic glutamate receptors in the goldfish brain. Brain research, 1999, Jul-10, Volume: 834, Issue:1-2 Topics: Animals; Brain; Cyclopropanes; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Goldfish; Male; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tissue Distribution	1999
Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes. Glia, 1999, Volume: 27, Issue:3 Topics: Adenosine; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glycine; Kinetics; Nerve Growth Factors; Neuroglia; Proline; Rats; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Transcription, Genetic	1999
[Functional coupling between metabotropic glutamate receptors and G proteins in rat cerebral cortex]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1999, Volume: 74, Issue:4 Topics: Animals; Cerebral Cortex; Cyclopropanes; Glycine; GTP Phosphohydrolases; GTP-Binding Proteins; Male; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction	1999
Type I and II metabotropic glutamate receptors mediate depressor and bradycardic actions in the nucleus of the solitary tract of anaesthetized rats. European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3 Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Heart Rate; Indans; Male; Microinjections; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Solitary Nucleus	1999
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors. Brain research, 1999, Oct-09, Volume: 844, Issue:1-2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium	1999
Evidence that DHPG-induced nociception depends on glutamate release from primary afferent C-fibres. Neuroreport, 2000, Jun-05, Volume: 11, Issue:8 Topics: 4-Aminopyridine; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lamotrigine; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Neurons, Afferent; Nociceptors; Proline; Propionates; Rats; Rats, Long-Evans; Riluzole; Triazines	2000
2R,4R-4-Aminopyrrolidine-2,4-dicarboxylate (APDC) attenuates cortical EPSPs. Brain research, 2000, Aug-11, Volume: 873, Issue:2 Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Neuronal Plasticity; Neurons; Proline; Rats; Receptors, Metabotropic Glutamate; Synapses; Visual Cortex	2000
The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice. Neuroscience letters, 2001, Feb-16, Volume: 299, Issue:1-2 Topics: Animals; Anticonvulsants; Central Nervous System; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Female; Male; Mice; Mice, Inbred DBA; Proline; Receptors, Metabotropic Glutamate; Sound	2001
The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D1-like, but not D2-like, dopamine receptors in the rat nucleus accumbens. The European journal of neuroscience, 2001, Volume: 13, Issue:11 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminobutyrates; Animals; Benzoates; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Motor Activity; Neurons; Nucleus Accumbens; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Synaptic Transmission	2001
Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. Brain research, 2001, Jul-27, Volume: 908, Issue:2 Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Cyclobutanes; Cyclopropanes; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Glycine; Homocysteine; Male; Neuroprotective Agents; Organophosphorus Compounds; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures	2001
Differential modulation of the D1-like- and D2-like dopamine receptor-induced locomotor responses by group II metabotropic glutamate receptors in the rat nucleus accumbens. Neuropharmacology, 2001, Volume: 41, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acids; Animals; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Motor Activity; Nucleus Accumbens; Proline; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Xanthenes	2001
Role of group II and group III metabotropic glutamate receptors in spinal cord injury. Experimental neurology, 2002, Volume: 173, Issue:1 Topics: Aminobutyrates; Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Hyperalgesia; Male; Motor Activity; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Wounds, Nonpenetrating	2002
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Aug-01, Volume: 22, Issue:15 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Capsaicin; Colforsin; Dinoprostone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Protein alpha Subunits, Gi-Go; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neurons, Afferent; Pain Measurement; Pertussis Toxin; Phosphorylation; Proline; Receptors, Drug; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella	2002
Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons. American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:6 Topics: Animals; Barium; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cyclopropanes; Electric Conductivity; Glutamic Acid; Glycine; GTP-Binding Proteins; Guinea Pigs; Ion Channel Gating; Male; Myenteric Plexus; Neurons; Nifedipine; omega-Conotoxin GVIA; Pertussis Toxin; Proline; Receptors, Metabotropic Glutamate	2002
A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips. Methods and findings in experimental and clinical pharmacology, 2002, Volume: 24, Issue:10 Topics: Aged; Animals; Aspartic Acid; Cycloleucine; Evoked Potentials, Motor; Female; Gastric Fundus; Glutamic Acid; Humans; In Vitro Techniques; Intestine, Large; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Proline; Quisqualic Acid; Rats; Receptors, Glutamate; Rectum; Stomach	2002
Enhancement of low-voltage-activated calcium currents by group II metabotropic glutamate receptors in rat retinal ganglion cells. Molecular and cellular neurosciences, 2003, Volume: 23, Issue:3 Topics: Animals; Calcium; Calcium Channels; Cholera Toxin; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Genistein; GTP-Binding Proteins; Kinetics; Male; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Pertussis Toxin; Proline; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells	2003
Group II metabotropic glutamate receptors regulate the vulnerability to hypoxic brain damage. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jul-09, Volume: 23, Issue:14 Topics: Animals; Apoptosis; Blotting, Western; Brain; Colforsin; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fishes; Glutamic Acid; Goldfish; Hypoxia, Brain; In Vitro Techniques; Male; Proline; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Species Specificity	2003
Metabotropic glutamate receptor regulation of neuronal cell death. Experimental neurology, 2003, Volume: 184 Suppl 1 Topics: Animals; Bacterial Proteins; Caspase 3; Caspases; Cell Death; Cells, Cultured; Dipeptides; Dizocilpine Maleate; DNA-Binding Proteins; Drug Interactions; Embryo, Mammalian; Ganglia, Spinal; Glucose; Glutamates; In Situ Nick-End Labeling; Indicators and Reagents; Kainic Acid; Neurons; Oxidative Stress; Proline; Rats; Receptors, Metabotropic Glutamate; Repressor Proteins; Schwann Cells; Time Factors	2003
Prefrontal group II metabotropic glutamate receptor activation decreases performance on a working memory task. Annals of the New York Academy of Sciences, 2003, Volume: 1003 Topics: Amino Acids; Animals; Excitatory Amino Acid Antagonists; Extracellular Space; Feedback; Glutamates; Memory, Short-Term; Microinjections; Prefrontal Cortex; Proline; Psychomotor Performance; Rats; Receptors, AMPA; Xanthenes	2003
Bidirectional modulation of cystine/glutamate exchanger activity in cultured cortical astrocytes. Annals of the New York Academy of Sciences, 2003, Volume: 1003 Topics: Amino Acids; Animals; Astrocytes; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Cystine; Enzyme Activators; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Phosphotransferases; Proline; Rats; Receptors, Metabotropic Glutamate; Xanthenes	2003
Electrothermal atomic absorption spectrometric-determination of cobalt in human serum and urine. Acta pharmaceutica (Zagreb, Croatia), 2003, Volume: 53, Issue:2 Topics: Calibration; Cobalt; Humans; Indicators and Reagents; Proline; Quality Control; Regression Analysis; Spectrophotometry, Atomic; Temperature; Thiocyanates	2003
Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions. Brain pathology (Zurich, Switzerland), 2004, Volume: 14, Issue:4 Topics: Aged; Aged, 80 and over; alpha-Synuclein; Cell Fractionation; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Guanosine Triphosphate; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Lewy Body Disease; Male; Membrane Proteins; Microscopy, Confocal; Middle Aged; Nerve Tissue Proteins; Postmortem Changes; Proline; Propionates; Protein Binding; Quisqualic Acid; Radioligand Assay; Receptors, Glutamate; Signal Transduction; Synaptosomal-Associated Protein 25; Synucleins; Tritium; Type C Phospholipases	2004
Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. Experimental neurology, 2005, Volume: 192, Issue:2 Topics: Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Brain Injuries; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Fluoresceins; Fluorescent Dyes; Functional Laterality; Glucose; Glycogen; Homocysteine; Lactic Acid; Male; Nerve Degeneration; Organic Chemicals; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures; Time Factors; Xanthenes	2005
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology, 2005, Volume: 49 Suppl 1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Aminobutyrates; Anesthetics, Local; Animals; Animals, Newborn; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Glycine; In Vitro Techniques; Lidocaine; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Patch-Clamp Techniques; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides; Synaptic Transmission; Xanthenes	2005
Vagal afferent control of opioidergic effects in rat brainstem circuits. The Journal of physiology, 2006, Sep-15, Volume: 575, Issue:Pt 3 Topics: Animals; Brain Stem; CREB-Binding Protein; Cyclic AMP; Enkephalin, Methionine; Evoked Potentials; gamma-Aminobutyric Acid; Gastrointestinal Tract; Glutamate Decarboxylase; Glutamates; In Vitro Techniques; Isoenzymes; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Opioid Peptides; Phosphorylation; Presynaptic Terminals; Proline; Rats; Receptors, Metabotropic Glutamate; Receptors, Opioid, mu; Somatostatin; Synaptic Transmission; Vagotomy; Vagus Nerve	2006
Involvement of group II metabotropic glutamate receptors in stress-induced behavioural sensitization. Psychopharmacology, 2007, Volume: 191, Issue:2 Topics: Amygdala; Animals; Behavior, Animal; Brain Chemistry; Conditioning, Operant; Dose-Response Relationship, Drug; Electroshock; Foot; Hippocampus; Injections, Intraperitoneal; Male; Prefrontal Cortex; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stress, Psychological	2007
Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo. Neuroscience, 2007, Apr-25, Volume: 146, Issue:1 Topics: Animals; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamates; Male; Neural Inhibition; Physical Stimulation; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Vibrissae	2007
2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport, 2007, Sep-17, Volume: 18, Issue:14 Topics: Age Factors; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cells, Cultured; Dentate Gyrus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Male; Phosphopyruvate Hydratase; Proline; Rats; Rats, Sprague-Dawley	2007
Functional organization of presynaptic metabotropic glutamate receptors in vagal brainstem circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Aug-22, Volume: 27, Issue:34 Topics: Amino Acids; Animals; Animals, Newborn; Brain Stem; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastrointestinal Tract; Glutamates; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Proline; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Vagotomy; Vagus Nerve	2007
Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch. Toxicon : official journal of the International Society on Toxinology, 2007, Dec-15, Volume: 50, Issue:8 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Pain; Proline; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Scorpion Venoms	2007
Effects of repeated exposure to cocaine on group II metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. Psychopharmacology, 2009, Volume: 203, Issue:3 Topics: Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dose-Response Relationship, Drug; Male; Microdialysis; Microinjections; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate	2009
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function. Brain research, 2009, Jan-12, Volume: 1248 Topics: Amino Acids; Animals; Capsaicin; Colforsin; Electrophysiological Phenomena; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Nociceptors; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; TRPV Cation Channels; Xanthenes	2009
Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain research, 2009, Jun-01, Volume: 1273 Topics: Aging; Animals; Brain; Convulsants; Cytoprotection; Drug Administration Schedule; Drug Interactions; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Homocysteine; Male; Nerve Degeneration; Neuroprotective Agents; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus; Treatment Outcome	2009
Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity. Brain research bulletin, 2009, May-29, Volume: 79, Issue:3-4 Topics: Amino Acids; Analgesics; Animals; Citrates; Dose-Response Relationship, Drug; Freund's Adjuvant; Hyperesthesia; Inflammation; Male; Neuroglia; Pain; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Xanthenes	2009
Ameliorative effect of a hippocampal metabotropic glutamate- receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats. Journal of pharmacological sciences, 2010, Volume: 113, Issue:1 Topics: Aminobutyrates; Animals; Drug Interactions; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Histamine H1 Antagonists; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Proline; Pyrilamine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Theta Rhythm	2010
Potentiation of morphine antiallodynic efficacy by ACPT-III, a group III metabotropic glutamate receptor agonist, in rat spinal nerve ligation-induced neuropathic pain. Pharmacology, biochemistry, and behavior, 2010, Volume: 96, Issue:1 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Ligation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Nerves; Treatment Outcome	2010
Effects of the group II mGlu receptor agonist 2R,4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury. Neurological research, 2011, Volume: 33, Issue:4 Topics: Animals; Brain Injuries; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agonists; Male; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate	2011
Pharmacological enhancement of glutamate transport reduces excitotoxicity in vitro. Restorative neurology and neuroscience, 2011, Volume: 29, Issue:5 Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Ceftriaxone; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Transporter 1; Glucose Transporter Type 1; Glutamic Acid; Nerve Degeneration; Neurotoxins; Proline; Rats; Rats, Sprague-Dawley; Up-Regulation	2011
Brain superoxide anion formation in immature rats during seizures: protection by selected compounds. Experimental neurology, 2012, Volume: 233, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Homocysteine; Infusions, Intraventricular; Male; Metalloporphyrins; Proline; Rats; Rats, Wistar; Seizures; Statistics, Nonparametric; Superoxides; Time Factors	2012
Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR. Neuropharmacology, 2013, Volume: 66 Topics: Allosteric Regulation; Amino Acids; Amino Acids, Dicarboxylic; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Indans; Ligands; Mice; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Neurons; Optical Imaging; Primary Cell Culture; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sulfonamides	2013
Peripheral group II and III metabotropic glutamate receptors in the knee joint attenuate carrageenan-induced nociceptive behavior in rats. Neuroscience letters, 2013, May-10, Volume: 542 Topics: Animals; Arthritis, Experimental; Behavior, Animal; Carrageenan; Hindlimb; Hyperalgesia; Joints; Male; Nociception; Pain; Pain Threshold; Physical Stimulation; Proline; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Weight-Bearing	2013
Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA. Journal of immunology (Baltimore, Md. : 1950), 2013, Dec-15, Volume: 191, Issue:12 Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; B-Lymphocytes; bcl-2-Associated X Protein; Caspases; Cell Transformation, Viral; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Melphalan; Mitochondria; Neoplasm Proteins; Nuclear Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Protein Interaction Mapping; Protein Isoforms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins; Pyridines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transcriptional Activation; Tumor Protein p73; Tumor Suppressor Proteins; Xeroderma Pigmentosum Group A Protein	2013
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. World journal of gastroenterology, 2015, Jan-21, Volume: 21, Issue:3 Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Ethanol; Excitatory Amino Acid Agonists; Humans; Hyperalgesia; Liver; Male; Morphine; Nociceptin; Nociception; Opioid Peptides; Pain Threshold; Pancreas; Pancreatitis, Alcoholic; Proline; Rats, Inbred F344; Receptors, Metabotropic Glutamate; Time Factors; Visceral Pain	2015
Inhibitory effect of group II mGluR agonist 2R, 4R-APDC on cell proliferation in dentate gyrus in rats with epileptic seizure. European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:15 Topics: Animals; Anticonvulsants; Cell Proliferation; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Male; Neuroprotective Agents; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate	2015
2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures. Neurochemical research, 2018, Volume: 43, Issue:3 Topics: Animals; Animals, Newborn; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Male; Memory; MicroRNAs; Proline; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Up-Regulation	2018