proguanil has been researched along with biguanides in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (59.18) | 18.7374 |
| 1990's | 10 (20.41) | 18.2507 |
| 2000's | 5 (10.20) | 29.6817 |
| 2010's | 2 (4.08) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Spicer, AJ | 1 |
| Famaey, JP; Fontaine, J; Ouédraogo, CO; Reuse, J | 1 |
| Moody, RR; Ochekpe, NA; Taylor, RB | 1 |
| Bygbjerg, I; Flachs, H; Hvidberg, EF; Ravn, P; Rønn, A | 1 |
| Chebotar', NA | 1 |
| Booij, HL; Elferink, JG | 1 |
| Weinberg, ED | 1 |
| Chulay, JD; Sixsmith, DG; Watkins, WM | 1 |
| Moody, RR; Selkirk, AB; Taylor, RB | 1 |
| Chiba, K; Darmansjah, I; Ishizaki, T; Kusaka, M; Setiabudy, R | 1 |
| Breckenridge, AM; Edwards, G; Helsby, NA; Ward, SA | 1 |
| Brøsen, K; Flachs, H; Skjelbo, E | 1 |
| Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ | 1 |
| Chiba, K; Ishizaki, T; Kusaka, M; Setiabudy, R | 1 |
| Kolawole, JA; Moody, RR; Taylor, RB | 1 |
| Alexander, C; Nathwani, D; Taylor, RB; Zimbler, N | 1 |
| Brøsen, K; Jeppesen, U; Rasmussen, BB | 1 |
| Bergqvist, Y; Funding, L; Krysèn, B; Leek, T; Yvell, K | 1 |
| Bergqvist, Y; Funding, L; Kaneko, A; Krysén, B; Leek, T | 1 |
| Low, AS; Reid, RG; Taylor, RB | 1 |
| Jarprung, D; Kamchonwongpaisan, S; Saesaengseerung, N; Sirawaraporn, W; Vilaivan, T; Yuthavong, Y | 1 |
| Lockwood, TD; Raymer, ML; Sweeney, D | 1 |
| Gross, AS; Hoskins, JM; Shenfield, GM | 1 |
| CUTTING, W | 1 |
| STERNE, J | 1 |
| MALOWAN, LS; OWENS, TP | 1 |
| CURD, FH; DAVEY, DG; HENDRY, JA; ROSE, FL | 1 |
| GRANT, JS | 1 |
| GUNTHER, CE | 1 |
| BISHOP, A; McCONNACHIE, EW | 1 |
| GOONETILLEKE, MA | 1 |
| BALLIF, L; CIUCA, M | 1 |
| DIXON, DS | 1 |
| BRUCE-CHWATT, JM; BRUCE-CHWATT, LJ | 1 |
| DRANE, P; PERRILL, CV | 1 |
| PLATA, AA | 1 |
| Charman, WN; Chiu, FC; Leveque, NL | 1 |
| SHULTZ, RC | 1 |
| GENTHER, CS; SCHMIDT, LH | 1 |
| WISEMAN, G | 1 |
| CHOUDHURY, M | 1 |
| BAMI, HL; GUHA, PC; IYER, BH | 1 |
| LODENS, JG; van GOOR, WT | 1 |
| Bridges, HR; Hirst, J; Jones, AJ; Pollak, MN | 1 |
| desBORDES, C; Kim, H; Lea, MA | 1 |
| Bharatam, PV; Kathuria, D; Raul, AD; Wanjari, P | 1 |
| Cao, Y; Luo, Y; Wang, W; Wang, Z; Xiao, D; Xu, S; Yang, X | 1 |
| Liu, J; Peng, M; Tang, X; Wang, W; Xiao, D; Xu, C; Xu, S; Yang, X; Zhou, S; Zhou, X | 1 |
2 review(s) available for proguanil and biguanides
| Article | Year |
|---|---|
Antimicrobial activities of biguanides.
Topics: Alkylation; Anti-Infective Agents; Antimalarials; Antiviral Agents; Benzene Derivatives; Biguanides; Biological Assay; Chemical Phenomena; Chemistry; Disinfectants; Orthomyxoviridae; Proguanil | 1968 |
Biguanides: Species with versatile therapeutic applications.
Topics: Anti-Infective Agents; Antineoplastic Agents; Biguanides; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Proguanil | 2021 |
2 trial(s) available for proguanil and biguanides
| Article | Year |
|---|---|
Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide.
Topics: Administration, Oral; Adult; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Biguanides; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Folic Acid Antagonists; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Proguanil; Selective Serotonin Reuptake Inhibitors; Triazines | 1997 |
Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.
Topics: Adult; Alleles; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Asian People; Biguanides; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Proguanil; Triazines | 2003 |
45 other study(ies) available for proguanil and biguanides
| Article | Year |
|---|---|
Treatment and chemoprophylaxis of malaria.
Topics: Aminoquinolines; Antimalarials; Biguanides; Chloroquine; Dapsone; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Quinine; Sulfonamides | 1979 |
Pharmacological effects of chloroguanide and some other biguanides on the guinea-pig isolated ileum.
Topics: Animals; Biguanides; Electric Stimulation; Guinea Pigs; Hypoglycemic Agents; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Proguanil | 1979 |
Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography.
Topics: Biguanides; Chromatography, High Pressure Liquid; Humans; Kinetics; Proguanil; Triazines | 1987 |
Human pharmacokinetics of proguanil and its metabolites.
Topics: Adult; Biguanides; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Erythrocytes; Female; Half-Life; Humans; Kinetics; Male; Proguanil; Triazines | 1987 |
Embryotoxic and teratogenic action of proguanil, chlorproguanil, and cycloguanil on albino rats.
Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Biguanides; Embryo, Mammalian; Female; Fertilization; Mitosis; Ovum; Pregnancy; Proguanil; Rats; Teratogens; Triazines | 1974 |
Interaction of chlorhexidine with yeast cells.
Topics: Alkanes; Biguanides; Cell Membrane; Cells; Chlorobenzenes; Lactates; Liposomes; Metals; Potassium; Proguanil; Quaternary Ammonium Compounds; Saccharomyces cerevisiae; Time Factors | 1974 |
The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.
Topics: Animals; Biguanides; Chloroquine; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1984 |
High-performance liquid chromatography of proguanil, cycloguanil and 4-chlorophenylbiguanide using hydrophobic pairing ion and its application to serum assay.
Topics: Animals; Biguanides; Cattle; Chromatography, High Pressure Liquid; Humans; Proguanil; Surface-Active Agents; Triazines | 1980 |
Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.
Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cohort Studies; Female; Half-Life; Humans; Hydroxylation; Indonesia; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; Proguanil; Regression Analysis; Triazines | 1995 |
The multiple dose pharmacokinetics of proguanil.
Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Humans; Male; Polymorphism, Genetic; Proguanil; Triazines | 1993 |
Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.
Topics: Administration, Oral; Adult; Biguanides; Denmark; Female; Humans; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Proguanil; Sparteine; Triazines; Vietnam | 1993 |
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, Third; Proguanil; Triazines | 1993 |
Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.
Topics: Adult; Antimalarials; Biguanides; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Proguanil; Triazines | 1996 |
Determination of proguanil and metabolites in small sample volumes of whole blood stored on filter paper by high-performance liquid chromatography.
Topics: Antimalarials; Biguanides; Blood Specimen Collection; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Proguanil; Triazines | 1995 |
Correlation between proguanil and metabolites in plasma and saliva.
Topics: Antimalarials; Biguanides; Chromatography, High Pressure Liquid; Humans; Proguanil; Saliva; Triazines | 1995 |
Improved validated assay for the determination of proguanil and its metabolites in plasma, whole blood, and urine using solid-phase extraction and high-performance liquid chromatography.
Topics: Antimalarials; Biguanides; Biological Assay; Chromatography, High Pressure Liquid; Drug Monitoring; Folic Acid Antagonists; Humans; Proguanil; Reproducibility of Results; Sensitivity and Specificity; Triazines | 1998 |
Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-microl capillary blood samples dried on sampling paper.
Topics: Antimalarials; Biguanides; Capillaries; Chromatography, High Pressure Liquid; Humans; Paper; Proguanil; Reproducibility of Results; Sensitivity and Specificity; Triazines | 1998 |
Analysis of proguanil and its metabolites by application of the sweeping technique in micellar electrokinetic chromatography.
Topics: Biguanides; Chromatography, Micellar Electrokinetic Capillary; Proguanil; Sensitivity and Specificity; Triazines | 2001 |
Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.
Topics: Amino Acid Substitution; Animals; Antimalarials; Biguanides; Combinatorial Chemistry Techniques; Cyclization; Folic Acid Antagonists; Mutation; Plasmodium falciparum; Proguanil; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2003 |
Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents.
Topics: Animals; Antimalarials; Biguanides; Catalytic Domain; Cathepsin B; Chloroquine; Homeostasis; Hypoglycemic Agents; Lysosomes; Metals; Metformin; Proguanil; Protease Inhibitors; Rats; Zinc | 2003 |
Antifertility effects of biguanides.
Topics: Antimalarials; Biguanides; Fertility; Guanidine; Guanidines; Humans; Phenformin; Proguanil | 1962 |
[MECHANISM OF ACTION OF ANTIDIABETIC BIGUANIDES].
Topics: Antimalarials; Biguanides; Guanidine; Guanidines; Hypoglycemic Agents; Pharmacology; Proguanil | 1964 |
The estimation of n-chlorophenyl-isopropyl-biguanide (paludrine) by use of a modified Sakaguchi reaction.
Topics: Biguanides; Proguanil; Regression Analysis | 1959 |
N1-3:4-dichlorophenyl-N5-isopropyl diguanide, a derivative of proguanil highly active in avian malaria.
Topics: Animals; Biguanides; Humans; Malaria; Malaria, Avian; Proguanil | 1950 |
Acquired resistance to chloroguanide in the pigeon strain of Plasmodium relictum (Grassi and Feletti, 1891).
Topics: Animals; Biguanides; Columbidae; Humans; Immunologic Tests; Malaria; Plasmodium; Proguanil | 1950 |
Proguanil hydrochloride (paludrine) in the prevention and treatment of malaria in New Guinea.
Topics: Biguanides; Biomedical Research; Humans; Malaria; New Guinea; Proguanil | 1951 |
The stability of paludrine-resistance in Plasmodium gallinaceum in the absence of the drug.
Topics: Biguanides; Malaria; Plasmodium gallinaceum; Proguanil | 1950 |
Toxic reactions of paludrine.
Topics: Biguanides; Postoperative Complications; Proguanil | 1949 |
Paludrine treatment of experimental malaria infection; effective minimum doses.
Topics: Biguanides; Malaria; Proguanil | 1950 |
Paludrine (proguanil) as a malarial prophylactic amongst African labour in Kenya.
Topics: Biguanides; Black People; Humans; Kenya; Malaria; Proguanil | 1950 |
NEW and nonofficial remedies: chlorguanide hydrochloride.
Topics: Biguanides; Proguanil | 1950 |
Antimalarial drugs in West Africa, with particular reference to proguanil; results of a survey in Nigeria.
Topics: Africa, Western; Antimalarials; Biguanides; Data Collection; Humans; Malaria; Nigeria; Proguanil | 1950 |
The use of paludrine in malaria prevention.
Topics: Biguanides; Malaria; Proguanil | 1950 |
Treatment of giardiasis by the chloroguanide chlorhydrate.
Topics: Biguanides; Giardiasis; Humans; Proguanil | 1950 |
Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.
Topics: Administration, Oral; Animals; Antimalarials; Biguanides; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Freezing; Injections, Intravenous; Proguanil; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Triazines | 2006 |
Hydrogenolysis as a method for determining chlorguanide.
Topics: Biguanides; Proguanil | 1949 |
Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi.
Topics: Biguanides; Humans; Plasmodium cynomolgi; Proguanil | 1949 |
Haemolysis with paludrine and its acceleration in the haemocytometer chamber.
Topics: Biguanides; Cell Death; Hemolysis; Proguanil | 1949 |
Paludrine, a new anti-malarial drug.
Topics: Antimalarials; Biguanides; Malaria; Proguanil | 1947 |
Metachloridine-substituted aryl biguanides as possible antimalarial compounds.
Topics: Antimalarials; Biguanides; Malaria; Proguanil; Sulfonamides | 1948 |
[Paludrine (proguanil, chlorguanide) in clinical prophylaxis].
Topics: Biguanides; Chloroquine; Humans; Proguanil | 1950 |
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Topics: Animals; Antimalarials; Antineoplastic Agents; Biguanides; Cattle; Diabetes Mellitus, Type 2; Electron Transport Complex I; Hep G2 Cells; Humans; Metformin; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Proton-Translocating ATPases; Oxidative Phosphorylation; Plasmodium; Proguanil; Rats; Reperfusion Injury; Triazines | 2014 |
Effects of Biguanides on Growth and Glycolysis of Bladder and Colon Cancer Cells.
Topics: Biguanides; Buformin; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Culture Media; Glucose; Glycolysis; HT29 Cells; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Mitochondria; Phenformin; Proguanil; Urinary Bladder Neoplasms | 2018 |
Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length.
Topics: Adenylate Kinase; Antineoplastic Agents; Biguanides; Carbon; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fluorine Compounds; Gene Expression Regulation, Neoplastic; Humans; Molecular Structure; Neoplasms; Proguanil; Signal Transduction | 2021 |
Synthesis, Anticancer Activities, and Mechanism of N-heptyl-containing Biguanide Derivatives.
Topics: Antineoplastic Agents; Benzene; Biguanides; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Proguanil; Structure-Activity Relationship | 2022 |