proglumide has been researched along with lorglumide in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (22.70) | 18.7374 |
| 1990's | 83 (44.86) | 18.2507 |
| 2000's | 43 (23.24) | 29.6817 |
| 2010's | 17 (9.19) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, RS; Freidinger, RM; Gould, NP; Holloway, MK; Lotti, VJ; Whitter, WL | 1 |
| Durrant, LG; Hardcastle, JD; Morris, DL; Robertson, JF; Watson, SA | 1 |
| Brenner, L; Ritter, RC; Yox, DP | 1 |
| Fushiki, T; Kondo, A; Sugimoto, E; Tsuzuki, S | 1 |
| Appel, MJ; Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA | 1 |
| Borysewicz, R; Lee, PC; Mokotoff, M; Ren, KJ | 1 |
| Kasser, RJ; Renner, KJ; Wilkerson, JW | 1 |
| Bishop, LA; Black, JW; Gerskowitch, VP; Hull, RA; Shankley, NP | 1 |
| Blommaert, AG; IJzerman, AP; Melman, CT; Soudijn, W; van der Bent, A; van Wijngaarden, I | 1 |
| Almegård, B; Bill, A; Stjernschantz, J | 1 |
| Appel, MJ; Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; Sprij-Mooij, D; Van Garderen-Hoetmer, A; Woutersen, RA | 1 |
| Alison, MR; Calam, J; Deprez, PH; Egan, M; Sarraf, CE; Watanapa, P; Williamson, RC | 1 |
| Moriyoshi, Y; Shimizu, K; Shiratori, K; Takeuchi, T; Watanabe, S | 2 |
| Nagy, I; Pap, A; Takács, T; Varró, V | 2 |
| Fujii, N; Funakoshi, A; Miyasaka, K; Shinozaki, H; Wakasugi, H | 1 |
| Galas, MC; Lignon, MF; Martinez, J; Nagain, C; Rodriguez, M; Rozé, C | 1 |
| Andrus, CC; Kaminski, DL; Larsen, F; Schlarman, D | 1 |
| Folly, G; Papp, M; Varga, G | 2 |
| Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
| Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA | 3 |
| Kellstein, DE; Mayer, DJ | 2 |
| Berger, Z; Issoual, D; Laugier, R | 1 |
| de Jong, AJ; Jansen, JB; Lamers, CB; Niebel, W; Rovati, LC; Singer, MV | 2 |
| Alison, MR; Beardshall, K; Calam, J; Efa, EF; Sarraf, CE; Watanapa, P; Williamson, RC | 1 |
| Chariot, J; Hugonet, F; Nagain, C; Rozé, C; Tsocas, A | 1 |
| Gaginella, TS; Kachur, JF; Phillips, GS | 1 |
| Funakoshi, A; Kitani, K; Matsumoto, M; Miyasaka, K; Nakamura, R; Sakai, H; Sakamoto, S | 1 |
| Colton, DG; Dodds, WJ; Hanyu, N; Hogan, WJ; Layman, RD | 1 |
| Andrus, C; Kaminski, DL; Schlarman, D; Westfall, S | 1 |
| Bennett, A; D'Amato, M; Stamford, IF | 1 |
| Kellstein, DE; Mayer, DJ; Price, DD | 1 |
| Gaudreau, P; Lavigne, GJ; Quirion, R | 1 |
| Baba, S; Fujii, M; Fujisawa, T; Hasegawa, H; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Aired, S; Esclassan, J; Hollande, E; Murat, C; Vincensini, P | 1 |
| Brandonisio, R; Chiloiro, M; Di Ciaula, A; Maggi, V; Palasciano, G; Portincasa, P | 1 |
| Chang, TM; Chey, WY; Lee, KY; Li, P | 1 |
| Ferrell, LD; Grendell, JH; Lüthen, R; Niederau, C; Niederau, M; Strohmeyer, G | 1 |
| Jansen, JB; Kuijpers, IJ; Lamers, CB; van de Brug, FJ | 1 |
| Funakoshi, A; Kitani, K; Miyasaka, K; Shikado, F | 1 |
| Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA | 2 |
| Hashimoto, T; MacLellan, DG; Poston, GJ; Thompson, JC; Townsend, CM; Upp, JR | 1 |
| Almegård, B; Andersson, SE; Bill, A | 1 |
| Konda, Y; Matozaki, T; Nagao, M; Nakano, O; Nishisaki, H; Sakamoto, C | 1 |
| Bastié, MJ; Pradayrol, L; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Iwamoto, Y; Kuzuya, T; Yamamoto, R | 1 |
| Grendell, JH; Liddle, RA; Niederau, C; Williams, JA | 1 |
| Barranco, SC; MacLellan, DG; Poston, GJ; Thompson, JC; Townsend, CM; Upp, JR | 1 |
| Grendell, JH; Niederau, C; Niederau, M; Strohmeyer, G | 1 |
| Dobronyi, I; Papp, M; Scarpignato, C; Varga, G | 1 |
| Chang, JH; Moriyoshi, Y; Shimizu, K; Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
| Gardner, JD; Jensen, RT; Maton, PN; Menozzi, D | 1 |
| Gomez, G; Green, D; Rajaraman, S; Thompson, JC; Townsend, CM; Uchida, T | 1 |
| Papp, M; Scarpignato, C; Varga, G | 1 |
| Debas, HT; Mulholland, MW | 1 |
| Abe, M; Funakoshi, A; Shinozaki, H; Wakasugi, H | 1 |
| Baba, S; Inui, A; Sakatani, N | 1 |
| Barrett, RW; Holladay, MW; Kerwin, JF; Lin, CW; Miller, TR; Nadzan, AM; Wagenaar, F; Witte, D; Wolfram, CA | 1 |
| Dembinski, A; Jaworek, J; Konturek, PK; Konturek, SJ; Warzecha, Z | 1 |
| Ahrén, B; Karlsson, S | 1 |
| Burt, S; Kerwin, JF; Kopecka, H; Lin, CW; Miller, T; Nadzan, AM; Witte, D | 1 |
| de Jong, AJ; Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA | 2 |
| Altar, AC; Cosi, C; Wood, PL | 1 |
| Aprahamian, M; Damgé, C; Hajri, A | 1 |
| Funakoshi, A; Kitani, K; Miyasaka, K; Nakamura, R | 2 |
| Altar, CA; Kim, HS; Petrack, B; Steel, DJ; Wood, PL | 1 |
| Sinton, CM | 2 |
| Murphy, RB; Schneider, LH; Smith, GP | 1 |
| de Jong, AJ; Jansen, JB; Lamers, CB | 1 |
| Bani, M; Chisté, R; Makovec, F; Revel, L; Rovati, LA; Rovati, LC | 1 |
| Konturek, P; Konturek, SJ; Laskiewicz, J; Thor, P | 1 |
| Jiang, LH; Kasser, RJ; Wang, RY | 1 |
| Funakoshi, A; Kitani, K; Miyasaka, K; Shinozaki, H | 1 |
| Baba, S; Inoue, T; Inui, A; Morioka, H; Oya, M; Sakatani, N | 2 |
| Cieszkowski, M; Hladij, M; Konturek, SJ; Szewczyk, K; Tasler, J | 1 |
| Bani, M; Cereda, R; Chisté, R; Makovec, F; Pacini, MA; Revel, L; Rovati, LA; Rovati, LC; Setnikar, I | 1 |
| Bani, M; Chistè, R; Makovec, F; Revel, L; Rovati, LC; Setnikar, I | 1 |
| Bani, M; Cereda, R; Chistè, R; Makovec, F; Pacini, MA; Revel, L; Rovati, LC | 1 |
| Barthó, L; Holzer, P; Lembeck, F; Lippe, IT; Setnikar, I | 1 |
| Bareggi, SR; Bianchi, M; Mantegazza, P; Panerai, AE; Rovati, LC | 1 |
| Cerino, DJ; Change, RS; Kling, PJ; Lotti, VJ | 1 |
| Aprahamian, M; Bernard, C; Damgé, C; Evrard, S; Hoeltzel, A; Marescaux, J; Mutter, D | 1 |
| Williams, JA; Yule, DI | 1 |
| Gaw, AJ; Hills, DM; Spraggs, CF | 1 |
| Alcon, S; Camello, PJ; Estévez, MJ; Pariente, JA; Pozo, MJ; Salido, GM | 1 |
| De Pont, JJ; Hoenderop, JG; Van Emst-De Vries, SE; Van Hoof, HJ; Van Mackelenbergh, MG; Willems, PH | 1 |
| Funakoshi, A; Matsumoto, M; Miyasaka, K; Okubo, K | 1 |
| Wang, SX | 1 |
| Alaggio, R; Behboo, R; Khajeturian, E; Militello, C; Pedrazzoli, S; Perasole, A; Rovati, L; Sperti, C | 1 |
| Ballatori, N; Chey, WY; Li, P; Sztefko, K | 1 |
| Blackmore, M; Doherty, E; Hirst, BH; Manning, JE | 1 |
| Ohtsuka, T; Yokose, K | 1 |
| Aprahamian, M; Damgé, C; Doffoël, M; Garaud, JC; Hajri, A; Karsenty, L | 1 |
| Calam, J; Deprez, PH; Flaks, B; Oztas, H; Watanapa, P; Williamson, RC | 1 |
| Alison, MR; Emons, VE; Sarraf, CE; Watanapa, P; Williamson, RC | 1 |
| Choi, YS; Kim, YH; Song, DK; Suh, HW | 1 |
| Hashimoto, S; Inoue, T; Izumi, T; Koyama, T; Ohmori, T; Tsuchiya, K | 1 |
| Dickenson, JM; Hill, SJ | 1 |
| Kim, KW; Kim, YH; Kwon, SH; Min, BH; Song, DK; Suh, HW | 1 |
| Cheeseman, CI; Hirsh, AJ; Kammila, S; Tsang, R | 1 |
| Dunlop, J; Evans, N; Zhang, Y | 1 |
| Pol, O; Puig, MM | 1 |
| Fukamauchi, F; Kusakabe, M; Mataga, N; Wang, YJ | 1 |
| Fujimoto, JM; Lin, W; Rady, JJ | 1 |
| Cook, CJ; Jacobson, LH | 1 |
| Chang, FY; Chen, JJ; Chen, TS; Chiao, YC; Doong, ML; Huang, SW; Kau, MM; Lin, H; Lu, CC; Tsai, SC; Wang, PS; Yeh, JY | 1 |
| Greenberg, D | 1 |
| Izumi, T | 1 |
| Burghardt, B; Gacsályi, I; Kordás, K; Szénási, G; Varga, G | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ; Smith, DJ | 1 |
| de Tullio, P; Delarge, J; Pirotte, B | 1 |
| Felicio, LF; Miranda-Paiva, CM | 1 |
| Edwards, GL; Power, JD | 1 |
| Pap, A; Sterczer, A; Szénási, G; Vörös, K | 1 |
| Amos, HE; Azain, MJ; Barb, CR; Edwards, GL; Froetschel, MA | 1 |
| Caruso, ML; Guerra, V; Lorusso, D; Makovec, F; Maselli, MA; Mennuni, L; Pezzolla, F; Piepoli, AL | 1 |
| Buéno, L; Fioramonti, J; Kania, BF; Kania, K; Matczuk, J; Romanowicz, K | 1 |
| Chang, FY; Hung, CR; Pau, KY; Wang, PS; Wu, CL | 2 |
| Ivanov, AI; Kulchitsky, VA; Romanovsky, AA | 1 |
| Ishige, A; Kase, Y; Kurauchi, K; Mizoguchi, K; Satoh, K; Yuzurihara, M | 1 |
| DiBattista, D; Hollis-Walker, L; McKenzie, TL | 1 |
| Kilroy, G; Lin, L; Schwartz, GJ; Thomas, SR; York, DA | 1 |
| Green, GM; Jin, W | 1 |
| Guimarães, FS; Netto, CF | 1 |
| Burdyga, G; Dimaline, R; Dockray, GJ; Lal, S; Thompson, DG; Varro, A | 1 |
| Farook, JM; Lee, L; Moochhala, SM; Wang, Q; Wong, PT; Zhu, YZ | 1 |
| Cox, JE; Kelm, GR; Meller, ST; Randich, A | 1 |
| Covasa, M; Hayes, MR; Savastano, DM | 1 |
| Bartolomé-Nebreda, JM; Cenarruzabeitia, E; Del Río, J; García-López, MT; González-Muñiz, R; Herranz, R; Latorre, M | 1 |
| Cong, B; Gao, WJ; Gu, ZY; Xu, SJ; Yao, YX | 1 |
| Doong, ML; Huang, WJ; Liu, YW; Pu, HF; Tseng, WM; Wang, PS; Wang, SW | 1 |
| Andresen, MC; Appleyard, SM; Bailey, TW; Doyle, MW; Jin, YH; Low, MJ; Smart, JL | 1 |
| Castañeda, TR; Cota, D; D'Alessio, DA; Proulx, K; Seeley, RJ; Tschöp, MH; Tso, P; Woods, SC | 1 |
| Baptista, V; Coleman, FH; Rogers, RC; Travagli, RA; Zheng, ZL | 1 |
| Covasa, M; Gulley, S; Ritter, RC; Sayegh, AI | 1 |
| Acuña-Castroviejo, D; Escames, G; García-Navarro, A; González-Puga, C; León, J; López-Cantarero, M; Ros, E | 1 |
| Cong, B; Gao, WJ; Gu, ZY; Li, SJ; Ling, YL; Ma, CL; Xu, SJ; Yao, YX | 1 |
| Micevych, P; Quesada, A | 1 |
| Cong, B; Gao, F; Gu, ZY; Ling, YL; Liu, X; Ma, LQ; Ping, J; Wang, XY; Xu, JR; Yan, YX; Zhao, L | 1 |
| Lee, R; Liu, M; Lo, CM; Ma, L; Qin, A; Raybould, HE; Sakai, RR; Tso, P; Woods, SC; Zhang, DM | 1 |
| Ohinata, K; Shimano, T; Sonoda, S; Yoshikawa, M | 1 |
| Jaworek, J; Konturek, SJ; Kot, M; Leja-Szpak, A; Macko, M; Mitis-Musioł, M; Nawrot-Porabka, K; Pawlik, WW; Szklarczyk, J | 1 |
| Travagli, RA; Viard, E; Wan, S; Zheng, Z | 1 |
| Coleman, FH; Travagli, RA; Wan, S | 1 |
| Davidson, WS; Liu, M; Lo, CM; Ma, L; Pearson, K; Raybould, HE; Sakai, RR; Sun, W; Tso, P; Woods, SC; Zhang, DM | 1 |
| Chambon, P; Gieske, MC; Hudgins, S; Kim, BG; Kim, HJ; Ko, C; Krust, A | 1 |
| Cevik Aras, H; Ekström, J | 1 |
| Doong, ML; Wang, PS; Wu, CL | 1 |
| Jaworek, J; Konturek, SJ; Kot, M; Leja-Szpak, A; Mitis-Musioł, M; Nawrot-Porabka, K; Pawlik, WW; Szklarczyk, J | 1 |
| Bae, H; Han, JB; Hong, MC; Jeong, H; Jin, YH; Kim, SK; Kim, Y; Lee, G; Lee, H; Min, BI; Shin, MK; Woo, HS | 1 |
| Gao, LP; Liu, JF; Lu, HL; Sun, J; Wang, QZ; Wen, SW; Zhang, J; Zhang, SW | 1 |
| Aras, HC; Ekström, J | 1 |
| Hara, I; Hayashi, H; Kagawa, K; Kirisawa, R; Onaga, T; Sugita, A; Wakaiki, R | 1 |
| Burdyga, G; de Lartigue, G; Dimaline, R; Dockray, GJ; Morris, R; Raybould, HE; Thompson, DG; Varro, A | 1 |
| Bombardelli, E; Cabras, C; Carai, MA; Colombo, G; Donzelli, F; Fantini, N; Gessa, GL; Lobina, C; Morazzoni, P; Riva, A | 1 |
| Sartor, DM; Verberne, AJ | 1 |
| Bae, H; Jeong, H; Kim, J; Kim, SK; Lee, H; Min, BI; Nam, S; Woo, HS | 1 |
| Iwasaki, M; Lipkowski, AW; Marczak, ED; Ohinata, K; Usui, H; Yamada, Y; Yoshikawa, M | 1 |
| Cevik-Aras, H; Ekström, J | 1 |
| Che, T; Feng, M; Liu, C; Liu, K; Luo, Y; Lv, Y; Sun, H | 1 |
| Crespo, I; Gómez de Heras, R; López-Moreno, JA; Orio, L; Reyes-Cabello, C; Rodríguez de Fonseca, F | 1 |
| Giri, S; Kumar, A; Mullangi, R; Pawar, GV; Police, A; Rajagopal, S; Sharma, K | 1 |
| Deeg, M; Echner, H; Ernemann, U; Heckl, S; Horger, M; Kalbacher, H; Klose, U; Nägele, T; Schwentner, C; Sheikh, S; Sturzu, A | 1 |
| Conti, G; Cossu, M; Diana, M; Ekström, J; Isola, M; Isola, R; Lantini, MS; Loy, F; Riva, A; Solinas, P | 1 |
| Arai, T; Kagebayashi, T; Kino, K; Kontani, N; Mizushige, T; Ohinata, K; Yamada, Y | 1 |
| Chang, FY; Doong, ML; Ho, LT; Huang, SW; Huang, WJ; Hwang, JL; Juan, CC; Lee, JL; Seow, KM | 1 |
| Beyak, MJ; Webster, WA | 1 |
| Arnold, M; Liu, M; Lo, CC; Shen, L; Tso, P; Wang, DQ; Woods, SC | 1 |
| Baimoukhametova, DV; Bains, JS; Crosby, KM; Pittman, QJ | 1 |
| Chen, D; Chen, H; Hao, J; Li, Z; Qi, J; Tang, N; Tian, Z; Wang, B; Wang, S; Wu, Y; Zhang, X | 1 |
| Chen, D; Chen, H; Li, Z; Qi, J; Tang, N; Tian, Z; Wang, B; Wang, M; Wang, S; Wu, Y; Xu, S; Zhang, X | 1 |
| Inoue, K; Koyama, D; Matsumura, S; Ohinata, K; Sasai, M; Sun, X | 1 |
2 review(s) available for proglumide and lorglumide
| Article | Year |
|---|---|
[Cholecystokinin receptor antagonists].
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Furans; Indoles; Meglumine; Molecular Sequence Data; Proglumide; Receptors, Cholecystokinin; Sincalide; Thiophenes | 1993 |
Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists).
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Humans; Indoles; Keto Acids; Ligands; Meglumine; Peptoids; Proglumide; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spiro Compounds; Structure-Activity Relationship; Tetragastrin | 1999 |
183 other study(ies) available for proglumide and lorglumide
| Article | Year |
|---|---|
Novel glutamic acid derived cholecystokinin receptor ligands.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chemistry, Physical; Cholecystokinin; Computer Graphics; Glutamates; Guinea Pigs; Ligands; Models, Molecular; Molecular Conformation; Pancreas; Rats; Receptors, Cholecystokinin; Structure-Activity Relationship | 1990 |
Inhibition of gastrin-stimulated growth of gastrointestinal tumour cells by octreotide and the gastrin/cholecystokinin receptor antagonists, proglumide and lorglumide.
Topics: Animals; Binding Sites; Gastrins; Gastrointestinal Neoplasms; Octreotide; Proglumide; Rats; Receptors, Cholecystokinin; Somatostatin; Tumor Cells, Cultured | 1992 |
CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients.
Topics: Amylases; Animal Nutritional Physiological Phenomena; Animals; Benzodiazepinones; Catheterization; Cholecystokinin; Devazepide; Duodenum; Eating; Intestines; Male; Maltose; Oleic Acid; Oleic Acids; Phenylalanine; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Satiety Response; Sincalide; Stomach | 1992 |
Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J).
Topics: Amylases; Animals; Base Sequence; Blotting, Northern; Cell Line; Cholecystokinin; Chymotrypsinogen; Gene Expression Regulation; Growth Substances; Intercellular Signaling Peptides and Proteins; Male; Molecular Sequence Data; Pancreas; Proglumide; Rats; Rats, Inbred Strains; RNA, Messenger; Trypsin Inhibitor, Kazal Pancreatic | 1992 |
Effects of cholecystokinin and bombesin on development of azaserine-induced pancreatic tumours in rats: modulation by the cholecystokinin receptor antagonist lorglumide.
Topics: Animals; Azaserine; Bombesin; Carcinogens; Cholecystokinin; Drug Synergism; Male; Pancreatic Neoplasms; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1992 |
Direct effect of bombesin on pancreatic and gastric growth in suckling rats.
Topics: Animals; Animals, Suckling; Bombesin; Cholecystokinin; DNA; Gastric Mucosa; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Sprague-Dawley; Stomach | 1992 |
Cholecystokinin antagonists inhibit in vivo voltammetric signals generated by KCl-induced slow wave depolarization in rat caudate.
Topics: Animals; Caudate Nucleus; Cholecystokinin; Dopamine; Male; Membrane Potentials; Microelectrodes; Potassium Chloride; Proglumide; Putamen; Rats; Rats, Sprague-Dawley | 1992 |
Combined dose-ratio analysis of cholecystokinin receptor antagonists, devazepide, lorglumide and loxiglumide in the guinea-pig gall bladder.
Topics: Analysis of Variance; Animals; Benzodiazepinones; Binding, Competitive; Biological Assay; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Muscle, Smooth; Pentagastrin; Proglumide; Receptors, Cholecystokinin; Sincalide | 1992 |
Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Computer Simulation; Devazepide; Glutamates; Guinea Pigs; Male; Models, Molecular; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Structure-Activity Relationship | 1992 |
Cholecystokinin contracts isolated human and monkey iris sphincters; a study with CCK receptor antagonists.
Topics: Aged; Aged, 80 and over; Animals; Cholecystokinin; Female; Humans; In Vitro Techniques; Iris; Macaca fascicularis; Male; Middle Aged; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Sincalide | 1992 |
Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
Topics: Animals; Azaserine; Body Weight; Cholecystokinin; Dietary Fats; Liver; Male; Organ Size; Pancreas; Pancreatic Neoplasms; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1992 |
Role of cholecystokinin in pancreatic adaptation to massive enterectomy.
Topics: Animals; Cholecystokinin; DNA; Immunohistochemistry; Intestine, Small; Male; Microscopy, Electron; Pancreas; Postoperative Period; Proglumide; Rats; Rats, Inbred Strains | 1992 |
Role of secretin and cholecystokinin in oleic acid-stimulated pancreatic secretion in rats.
Topics: Amylases; Animals; Bicarbonates; Cholecystokinin; Dose-Response Relationship, Drug; Duodenum; Male; Oleic Acids; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains; Secretin | 1990 |
The effect of long-term administration of lorglumide (CR 1409) on rat pancreatic growth and enzyme composition.
Topics: Amylases; Animals; Chymotrypsinogen; DNA; Lipase; Male; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Sincalide; Trypsinogen | 1990 |
Bioactivity of synthetic human cholecystokinin (CCK)-33 in vitro and in vivo.
Topics: Amylases; Animals; Cholecystokinin; Hormones; Humans; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Sincalide; Species Specificity; Swine | 1991 |
Synthetic CCK8 analogs with antagonist activity on pancreatic receptors: in vivo study in the rat, compared to non-peptidic antagonists.
Topics: Amino Acid Sequence; Amylases; Animals; Benzodiazepinones; Devazepide; Male; Molecular Sequence Data; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide | 1991 |
The effect of the CCK receptor antagonist CR 1409 on bile reflux pancreatitis in the opossum.
Topics: Amylases; Animals; Bile Reflux; Cholecystokinin; Common Bile Duct; Female; Glucagon; Insulin; Ligation; Male; Opossums; Organ Size; Pancreas; Pancreatitis; Proglumide; Receptors, Cholecystokinin | 1991 |
Increase in plasma corticosterone level does not participate in increase of amylase content induced by lorglumide in the newborn rat pancreas.
Topics: Amylases; Animals; Animals, Newborn; Corticosterone; Pancreas; Proglumide; Rats | 1991 |
Effect of lorglumide (CR-1409) on pancreatic secretory and trophic response to caerulein in newborn rats.
Topics: Amylases; Animals; Animals, Newborn; Body Weight; Ceruletide; Cholecystokinin; Corticosterone; Female; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Trypsin | 1991 |
Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-induced inhibition of gastric acid secretion in rats.
Topics: Animals; Cholecystokinin; Duodenum; Gastric Acid; Intestinal Mucosa; Male; Oleic Acid; Oleic Acids; Pentagastrin; Proglumide; Rats; Rats, Inbred Strains; Secretin | 1992 |
Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.
Topics: Animals; Carcinogens; Carcinoma; Carcinoma in Situ; Cholecystokinin; Cricetinae; Esters; Gabexate; Guanidines; Male; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Proglumide; Reference Values; Trypsin Inhibitors | 1991 |
Spinal co-administration of cholecystokinin antagonists with morphine prevents the development of opioid tolerance.
Topics: Analysis of Variance; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Spinal; Male; Morphine; Proglumide; Rats; Rats, Inbred Strains | 1991 |
CCK and PYY do not participate in the delayed inhibition of pancreatic secretion, after stimulation by duodenal oleic acid infusion.
Topics: Animals; Bicarbonates; Cholecystokinin; Duodenum; Gastrointestinal Hormones; Male; Oleic Acid; Oleic Acids; Pancreas; Peptide YY; Peptides; Proglumide; Proteins; Rats; Receptors, Cholecystokinin | 1991 |
Effect of the cholecystokinin-receptor antagonist lorglumide on pancreatic enzyme secretion stimulated by bombesin, food, and caerulein, giving similar plasma cholecystokinin concentrations in the dog.
Topics: Animals; Bicarbonates; Bombesin; Ceruletide; Cholecystokinin; Dogs; Eating; Female; Gastric Acid; Pancreas; Proglumide; Proteins | 1991 |
Effects of bombesin on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.
Topics: Animals; Body Weight; Bombesin; Cholecystokinin; Cricetinae; Liver; Male; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Proglumide | 1991 |
Inhibitory effect of a cholecystokinin antagonist on the proliferative response of the pancreas to pancreatobiliary diversion.
Topics: Adaptation, Physiological; Animals; Biliopancreatic Diversion; Cell Count; Cholecystokinin; Male; Mitosis; Organ Size; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Control of interdigestive and intraduodenal meal-stimulated pancreatic secretion in rats.
Topics: Animals; Atropine; Benzodiazepinones; Cholecystokinin; Devazepide; Digestion; Duodenum; Eating; Hexamethonium; Hexamethonium Compounds; Kinetics; Male; Muscle, Smooth; Pancreas; Pirenzepine; Proglumide; Rats; Rats, Inbred Strains; Reference Values; Vagotomy | 1990 |
Neuromodulation of guinea pig intestinal electrolyte transport by cholecystokinin octapeptide.
Topics: Animals; Atropine; Biological Transport; Bumetanide; Calcium; Culture Media; Dose-Response Relationship, Drug; Electrolytes; Electrophysiology; Guinea Pigs; Ileum; Intestinal Mucosa; Intestines; Male; Proglumide; Receptors, Cholecystokinin; Sincalide; Tetrodotoxin | 1991 |
Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini.
Topics: Animals; Bile Acids and Salts; Biological Assay; Cholecystokinin; Diabetes Mellitus; Gastrointestinal Diseases; Humans; Pancreas; Proglumide; Radioimmunoassay; Rats; Rats, Inbred Strains | 1991 |
Effect of two new cholecystokinin antagonists on gallbladder emptying in opossums.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Female; Gallbladder; Kinetics; Male; Opossums; Proglumide; Sincalide | 1991 |
The effect of cholecystokinin-receptor antagonists on cholecystokinin-stimulated bile flow in dogs.
Topics: Animals; Anti-Ulcer Agents; Benzamides; Bile; Bile Acids and Salts; Cholecystokinin; Corn Oil; Dogs; Electrolytes; Female; Glucagon; Insulin; Kinetics; Proglumide; Receptors, Cholecystokinin; Sincalide; Taurocholic Acid | 1991 |
Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Digestive System; Digestive System Physiological Phenomena; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Sincalide | 1991 |
Cholecystokinin and its antagonist lorglumide respectively attenuate and facilitate morphine-induced inhibition of C-fiber evoked discharges of dorsal horn nociceptive neurons.
Topics: Animals; Cholecystokinin; Electric Stimulation; Evoked Potentials; Male; Morphine; Nerve Fibers; Neurons; Pain; Proglumide; Rats; Rats, Inbred Strains; Sincalide; Spinal Cord | 1991 |
Cholecystokinin antagonists proglumide, lorglumide and benzotript, but not L-364,718, interact with brain opioid binding sites.
Topics: Animals; Benzamides; Benzodiazepinones; Binding Sites; Binding, Competitive; Brain; Cholecystokinin; Devazepide; Guinea Pigs; Male; Proglumide; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Proglumide analogues CR 1409 and CR 1392 inhibit cholecystokinin-stimulated insulin release more potently than exocrine secretion from the isolated perfused rat pancreas.
Topics: Animals; Cholecystokinin; Glutamine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Proglumide; Radioimmunoassay; Rats; Rats, Inbred Strains | 1990 |
Demonstration of a new resonance peak by proton NMR in rat pancreas stimulated with caerulein.
Topics: Animals; Ceruletide; Cytoplasmic Granules; Enzyme Precursors; Fasting; Magnetic Resonance Spectroscopy; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains | 1990 |
The effect of a novel CCK-antagonist (lorglumide) on human and guinea pig gallbladder strips: a tensiometric study.
Topics: Adult; Aged; Animals; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Proglumide; Receptors, Cholecystokinin; Sincalide; Species Specificity | 1990 |
Hormonal mechanism of sodium oleate-stimulated pancreatic secretion in rats.
Topics: Animals; Atropine; Bicarbonates; Cholecystokinin; Dose-Response Relationship, Drug; Male; Oleic Acid; Oleic Acids; Pancreas; Pancreatic Juice; Proglumide; Proteins; Rats; Rats, Inbred Strains; Reference Values; Secretin | 1990 |
Effects of long-term CCK stimulation and CCK blockade on pancreatic and intestinal growth, morphology, and function.
Topics: Animals; Cholecystokinin; Diet; Duodenum; Esters; Gabexate; Guanidines; Intestinal Mucosa; Mice; Mice, Inbred Strains; Pancreas; Proglumide; Protease Inhibitors; Time Factors | 1990 |
Effects of lorglumide on gastrin- and peptone-stimulated gastric acid secretion in rats.
Topics: Animals; Cholecystokinin; Gastric Acid; Gastrins; Male; Peptones; Proglumide; Rats; Rats, Inbred Strains | 1990 |
Role of cholecystokinin in the development of BOP-induced pancreatic lesions in hamsters.
Topics: Animals; Body Weight; Carcinogens; Cholecystokinin; Cocarcinogenesis; Cricetinae; Male; Nitrosamines; Organ Size; Pancreas; Pancreatic Neoplasms; Proglumide | 1990 |
Necessity of hyperglycemia for effects of endogenous cholecystokinin on insulin and pancreatic exocrine secretion in conscious rats.
Topics: Animals; Bile; Blood Glucose; Cholecystokinin; Consciousness; Glucose; Hyperglycemia; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains | 1990 |
The effect of CR 1409, a potent CCK receptor antagonist, on basal and stimulated pancreatic secretion in rat.
Topics: Animals; Bicarbonates; Dose-Response Relationship, Drug; Glutamine; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Secretory Rate; Sincalide | 1990 |
Comparison of the effect of lorglumide on pancreatic growth stimulated by camostate in rat and hamster.
Topics: Animals; Cholecystokinin; Cricetinae; DNA; Esters; Gabexate; Gelatin; Glutamine; Guanidines; Male; Mesocricetus; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Stimulation, Chemical; Trypsin Inhibitors | 1990 |
In vivo comparison of inhibition with proglumide and CR-1409 of cholecystokinin-induced pressure in the biliary tract of the guinea pig.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Gallbladder; Glutamine; Guinea Pigs; Male; Muscle Contraction; Pressure; Proglumide; Time Factors; Transducers | 1990 |
Cholecystokinin causes contraction of the pupillary sphincter in monkeys but not in cats, rabbits, rats and guinea-pigs: antagonism by lorglumide.
Topics: Animals; Cats; Cholecystokinin; Eye; Female; Guinea Pigs; Indomethacin; Macaca; Macaca fascicularis; Male; Miosis; Muscle Contraction; Muscles; Ocular Physiological Phenomena; Proglumide; Rabbits; Rats; Receptors, Cholecystokinin; Tetrodotoxin | 1990 |
Chronic administration of cholecystokinin antagonists reverses the enhancement of spinal morphine analgesia induced by acute pretreatment.
Topics: Analgesia; Animals; Cholecystokinin; Glutamine; Injections, Spinal; Male; Morphine; Proglumide; Rats; Rats, Inbred Strains; Spinal Cord | 1990 |
Effects of CCK-receptor antagonists on CCK-stimulated pepsinogen secretion and calcium increase in isolated guinea pig gastric chief cells.
Topics: Animals; Benzodiazepinones; Calcium; Cells, Cultured; Cholecystokinin; Devazepide; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Male; Pepsinogens; Proglumide; Receptors, Cholecystokinin; Signal Transduction; Sincalide | 1990 |
Role of cholecystokinin in bombesin- and meal-stimulated pancreatic polypeptide secretion in dogs.
Topics: Animals; Bombesin; Ceruletide; Cholecystokinin; Dogs; Female; Food; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1990 |
Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J).
Topics: Animals; DNA, Neoplasm; Gastrins; Glutamine; Ornithine Decarboxylase; Pancreatic Neoplasms; Proglumide; Rats; Receptors, Cholecystokinin; Thymidine; Tumor Cells, Cultured | 1990 |
CR-1409: a potent inhibitor of cholecystokinin-stimulated amylase release and cholecystokinin binding in rat pancreatic acini.
Topics: Amylases; Animals; Dose-Response Relationship, Drug; Glutamine; Male; N-Methylscopolamine; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Scopolamine Derivatives; Sincalide | 1987 |
Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsinogen; Esters; Gabexate; Glutamine; Guanidines; Male; Mice; Organ Size; Pancreas; Proglumide; Protease Inhibitors; Sincalide | 1987 |
Mechanisms of the trophic actions of bombesin on the pancreas.
Topics: Animals; Bombesin; Cholecystokinin; DNA; Hyperplasia; Pancreas; Polyamines; Proglumide; Proteins; Putrescine; Rats; Receptors, Cholecystokinin; RNA; Spermidine; Spermine | 1988 |
Comparative effects of CCK receptor antagonists on rat pancreatic secretion in vivo.
Topics: Amylases; Animals; Benzodiazepinones; Ceruletide; Cholecystokinin; Chymotrypsinogen; Devazepide; Dose-Response Relationship, Drug; Male; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Secretin | 1989 |
Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat.
Topics: Amylases; Anesthesia; Animals; Body Weight; Bombesin; Ceruletide; Cholecystokinin; DNA; Glutamine; In Vitro Techniques; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Trypsin | 1989 |
[Inhibitory effect of CR 1409 (cholecystokinin antagonist) on pancreatic exocrine secretion in rats].
Topics: Amylases; Animals; Cholecystokinin; Glutamine; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1989 |
Properties of receptors for gastrin and CCK on gastric smooth muscle cells.
Topics: Amylases; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Gastrins; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Pancreas; Peptide Fragments; Proglumide; Receptors, Cholecystokinin; Sincalide; Stomach; Tetragastrin | 1989 |
Involvement of cholecystokinin receptors in the adverse effect of glucocorticoids on diet-induced necrotizing pancreatitis.
Topics: Amylases; Animals; Choline Deficiency; Diet; Dose-Response Relationship, Drug; Ethionine; Female; Glucocorticoids; Hydrocortisone; Mice; Mice, Inbred Strains; Necrosis; Pancreas; Pancreatitis; Proglumide; Receptors, Cholecystokinin; Sincalide | 1989 |
Pancreatic secretory and trophic response to caerulein in rats: effect of proglumide and lorglumide.
Topics: Amylases; Animals; Body Weight; Ceruletide; DNA; Glutamine; In Vitro Techniques; Organ Size; Pancreas; Pancreatic Juice; Proglumide; Proteins; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Trypsin | 1989 |
Cholecystokinin receptor antagonism of stimulated pancreatic and gastric secretion.
Topics: Amylases; Animals; Food; Gastric Acid; Kinetics; Male; Pancreas; Pentagastrin; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide | 1989 |
The inhibitory effect of CR-1409 on amylase secretion and intracellular Ca2+ mobilization in rat pancreatic acini in vitro.
Topics: Amylases; Animals; Benzofurans; Calcium; Carbachol; Ceruletide; Cytoplasm; Fluorescent Dyes; Fura-2; Gastrin-Releasing Peptide; Glutamine; In Vitro Techniques; Male; Pancreas; Peptides; Perfusion; Proglumide; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1989 |
[The effect of cholecystokinin antagonists on satiety induced by cholecystokinin octapeptide in dogs].
Topics: Animals; Blood-Brain Barrier; Cholecystokinin; Dogs; Eating; Glutamine; Injections, Intravenous; Injections, Intraventricular; Proglumide; Receptors, Cholecystokinin; Sincalide | 1989 |
Distinct requirements for activation at CCK-A and CCK-B/gastrin receptors: studies with a C-terminal hydrazide analogue of cholecystokinin tetrapeptide (30-33).
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Calcium; Cholecystokinin; Devazepide; Gastrins; Guinea Pigs; Molecular Sequence Data; Peptide Fragments; Proglumide; Receptors, Cholecystokinin; Tetragastrin | 1989 |
Cholecystokinin receptor antagonism by peptidergic and non-peptidergic agents in rat pancreas.
Topics: Animals; Benzodiazepinones; Bombesin; Ceruletide; Cholecystokinin; Devazepide; DNA; Esters; Gabexate; Glutamine; Guanidines; Pancreas; Pentagastrin; Proglumide; Protease Inhibitors; Proteins; Rats; Receptors, Cholecystokinin | 1989 |
Effects of three different cholecystokinin receptor antagonists on basal and stimulated insulin and glucagon secretion in mice.
Topics: Animals; Benzodiazepinones; Blood Glucose; Devazepide; Female; Glucagon; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Proglumide; Receptors, Cholecystokinin | 1989 |
Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.
Topics: Benzodiazepines; Benzodiazepinones; Chemical Phenomena; Chemistry; Cholecystokinin; Devazepide; Drug Design; Glutamine; Molecular Conformation; Proglumide; Receptors, Cholecystokinin; Stereoisomerism; Structure-Activity Relationship | 1989 |
Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas.
Topics: Animals; Azaserine; Cholecystokinin; Esters; Gabexate; Glutamine; Guanidines; Male; Pancreatic Neoplasms; Precancerous Conditions; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide; Trypsin Inhibitors | 1989 |
Study into the role of cholecystokinin in bombesin-stimulated pancreatic growth in rats and hamsters.
Topics: Animals; Body Weight; Bombesin; Cholecystokinin; Cricetinae; DNA; Male; Mesocricetus; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Species Specificity; Time Factors | 1989 |
Effect of cholecystokinin on acetylcholine turnover and dopamine release in the rat striatum and cortex.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cholecystokinin; Corpus Striatum; Dopamine; Injections, Intraventricular; Male; Nerve Tissue Proteins; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1989 |
Effect of a new CCK-receptor antagonist, CR 1409, on pancreatic growth induced by caerulein, CCK-8, bombesin and gastrin-releasing peptide in the rat.
Topics: Animals; Bombesin; Ceruletide; Gastrin-Releasing Peptide; Gastrointestinal Hormones; Male; Organ Size; Pancreas; Peptides; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1989 |
Effect of CCK antagonists CR 1409 and CR 1505 on rat pancreatic exocrine secretion in vivo.
Topics: Animals; Caseins; Cholecystokinin; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Interactions between bile and pancreatic juice diversions on cholecystokinin release and pancreas in conscious rats.
Topics: Animals; Bile; Cholecystokinin; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Inhibition of climbing and mossy fiber input to mouse cerebellar Purkinje cells by cholecystokinin.
Topics: Animals; Cerebellum; Cholecystokinin; Cyclic GMP; Harmaline; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Motor Activity; Naloxone; Peptide Fragments; Proglumide; Purkinje Cells; Time Factors | 1988 |
Cholecystokinin modulates neurotransmission through the dentate gyrus.
Topics: Action Potentials; Animals; Benzamides; Electric Stimulation; Hippocampus; Iontophoresis; Male; Proglumide; Rats; Rats, Inbred Strains; Sciatic Nerve; Sincalide; Synaptic Transmission | 1988 |
Two proglumide analogues are equipotent antagonists of the inhibition of food intake by CCK-8.
Topics: Animals; Dose-Response Relationship, Drug; Eating; Glutamates; Male; Proglumide; Rats; Rats, Sprague-Dawley; Sincalide | 1988 |
Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas.
Topics: Animals; Azaserine; Bombesin; Cholecystokinin; Glutamine; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains | 1989 |
The cholecystokinin receptor antagonist CR1409 increases plasma cholecystokinin in rats.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Glutamine; Male; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Differentiation of central and peripheral cholecystokinin receptors by new glutaramic acid derivatives with cholecystokinin-antagonistic activity.
Topics: Animals; Benzamides; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; Mice; Pancreas; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide; Tetragastrin | 1986 |
Cholecystokinin in the regulation of intestinal motility and pancreatic secretion in dogs.
Topics: Animals; Benzodiazepinones; Bethanechol Compounds; Bicarbonates; Bombesin; Cholecystokinin; Devazepide; Dogs; Eating; Gastrins; Gastrointestinal Motility; Glutamine; Pancreatic Juice; Proglumide; Proteins; Reference Values | 1988 |
Cholecystokinin antagonist lorglumide reverses chronic haloperidol-induced effects on dopamine neurons.
Topics: Action Potentials; Animals; Dopamine; Glutamine; Haloperidol; Male; Nucleus Accumbens; Proglumide; Rats; Rats, Inbred Strains; Septal Nuclei; Sincalide; Substantia Nigra | 1988 |
Inhibitory effect of CR-1409, a competitive inhibitor of cholecystokinin, on pancreatic exocrine secretion in the conscious rat.
Topics: Animals; Bicarbonates; Cholecystokinin; Dose-Response Relationship, Drug; Female; Glutamine; Male; Pancreatic Juice; Proglumide; Proteins; Rats; Rats, Inbred Strains; Reference Values; Sincalide | 1988 |
Effects of cisapride on the pancreatic exocrine secretion in rats.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cholecystokinin; Cisapride; In Vitro Techniques; Male; Pancreas; Pancreatic Juice; Piperidines; Proglumide; Rats; Rats, Inbred Strains; Serotonin Antagonists | 1988 |
Comparison of effects of proglumide and CR 1409, a new glutaramic acid derivative, on CCK-8-induced pancreatic polypeptide and insulin secretion in the dog.
Topics: Animals; Cholecystokinin; Dogs; Glutamine; Insulin; Insulin Secretion; Pancreatic Polypeptide; Proglumide | 1988 |
Effect of cholecystokinin receptor antagonist on pancreatic responses to exogenous gastrin and cholecystokinin and to meal stimuli.
Topics: Animals; Cholecystokinin; Dogs; Food; Gastric Fistula; Gastrins; Glutamine; Pancreas; Pancreatic Fistula; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1988 |
Cholecystokinin and an evoked response in the dentate gyrus.
Topics: Animals; Cholecystokinin; Evoked Potentials; Hippocampus; Injections, Intraventricular; Male; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1988 |
Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists.
Topics: Animals; Cholecystokinin; Dogs; Gallbladder; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Muscle Contraction; Pancreas; Proglumide; Rats; Receptors, Cholecystokinin | 1987 |
Different peripheral and central antagonistic activity of new glutaramic acid derivatives on satiety induced by cholecystokinin in rats.
Topics: Animals; Dose-Response Relationship, Drug; Glutamine; Male; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Satiation; Sincalide | 1986 |
Antispasmodic activity on the gallbladder of the mouse of CR 1409 (lorglumide) a potent antagonist of peripheral CCK.
Topics: Animals; Atropine; Cholecystokinin; Dose-Response Relationship, Drug; Female; Gallbladder; Glutamine; Mice; Mice, Inbred Strains; Nifedipine; Papaverine; Parasympatholytics; Proglumide | 1987 |
Evaluation of a new and potent cholecystokinin antagonist on motor responses of the guinea-pig intestine.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Reflex | 1987 |
Proglumide has access to brain and antagonizes the central satiety effect of cholecystokinin octapeptide in the dog.
Topics: Animals; Blood-Brain Barrier; Brain; Dogs; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Glutamine; Infusions, Intravenous; Injections, Intraventricular; Proglumide; Satiation; Satiety Response; Sincalide; Time Factors | 1987 |
Effect of a cholecystokinin antagonist on some effects of diazepam.
Topics: Animals; Cholecystokinin; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Proglumide; Seizures | 1987 |
A new simple mouse model for the in vivo evaluation of cholecystokinin (CCK) antagonists: comparative potencies and durations of action of nonpeptide antagonists.
Topics: Administration, Oral; Animals; Benzodiazepinones; Binding, Competitive; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Female; Gastric Emptying; Mice; Proglumide; Sincalide; Time Factors | 1986 |
Implication of cholecystokinin in pancreatic adaptation after biliopancreatic bypass in the rat.
Topics: Adaptation, Physiological; Animals; Biliopancreatic Diversion; Body Weight; Cholecystokinin; Data Interpretation, Statistical; DNA; Male; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Wistar; RNA | 1994 |
CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor.
Topics: Amino Acid Sequence; Amylases; Animals; Benzodiazepinones; Calcium; Cholecystokinin; Devazepide; Male; Models, Biological; Molecular Sequence Data; Pancreas; Periodicity; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Signal Transduction; Sincalide | 1994 |
Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat.
Topics: Adrenalectomy; Adrenergic Agents; Animals; Benzodiazepinones; Blood Pressure; Bradycardia; Cholecystokinin; Decerebrate State; Devazepide; Dose-Response Relationship, Drug; Gastrins; Guanethidine; Heart Rate; Hormone Antagonists; Hormones; Hypertension; Indoles; Male; Meglumine; Pentagastrin; Phentolamine; Proglumide; Rats; Receptors, Cholecystokinin; Sincalide; Tetragastrin | 1995 |
Cholinergic dependence of pancreatic response to cholecystokinin in rats and guinea pigs.
Topics: Animals; Atropine; Cholecystokinin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Pancreas; Pancreatic Juice; Parasympathetic Nervous System; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1995 |
Receptor-evoked Ca2+ mobilization in pancreatic acinar cells: evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state.
Topics: Alkaloids; Animals; Brain; Calcium; Carbachol; Cholecystokinin; Fura-2; Inosine Triphosphate; Naphthalenes; Pancreas; Phosphorylation; Polycyclic Compounds; Proglumide; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mechanisms of stimulatory effect of neuromedin C on pancreatic exocrine secretion in conscious rats.
Topics: Animals; Bombesin; Cholecystokinin; Male; Omeprazole; Pancreas; Peptide Fragments; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Stimulation, Chemical | 1994 |
[Effect of cholecystokinin and its antagonists lorglumide, devazepide, and L-365,260 on gastrointestinal motility in rats].
Topics: Animals; Benzodiazepinones; Devazepide; Gastric Emptying; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Phenylurea Compounds; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide | 1993 |
Effect of cholecystokinin analogue caerulein and cholecystokinin antagonist lorglumide on pancreatic carcinogenesis in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Body Weight; Ceruletide; Chi-Square Distribution; DNA, Neoplasm; Male; Organ Size; Pancreas; Pancreatic Neoplasms; Proglumide; Random Allocation; Rats; Receptors, Cholecystokinin | 1994 |
CCK-receptor antagonists proglumide and loxiglumide stimulate bile flow and biliary glutathione excretion.
Topics: Animals; Bile; Bile Acids and Salts; Cholagogues and Choleretics; Dose-Response Relationship, Drug; Glutathione; Infusions, Intravenous; Liver; Male; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin | 1994 |
Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.
Topics: Benzamides; Benzodiazepinones; Cell Division; Devazepide; Gastrins; Humans; Indoles; Kidney Neoplasms; Meglumine; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Tumor Cells, Cultured; Wilms Tumor | 1994 |
Inhibition of growth of a transplanted rat pancreatic acinar carcinoma with CCK-8.
Topics: Animals; Carcinoma; Cell Division; Dose-Response Relationship, Drug; Neoplasm Transplantation; Pancreatic Neoplasms; Proglumide; Rats; Rats, Inbred Lew; Receptors, Cholecystokinin; Sincalide | 1993 |
Inhibitory effect of a cholecystokinin antagonist on pancreatic carcinogenesis after pancreatobiliary diversion.
Topics: Animals; Azaserine; Biliopancreatic Diversion; Body Weight; Cholecystokinin; Cocarcinogenesis; Male; Organ Size; Pancreas; Pancreatic Neoplasms; Precancerous Conditions; Proglumide; Rats; Rats, Wistar | 1993 |
Severe subcellular damage in the rat exocrine pancreas after pancreatobiliary diversion.
Topics: Acid Phosphatase; Animals; Bile Ducts; Cholecystokinin; Male; Microscopy, Electron; Pancreas; Pancreatic Ducts; Proglumide; Rats; Rats, Wistar | 1993 |
Involvement of different subtypes of cholecystokinin receptors in opioid antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; beta-Endorphin; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Meglumine; Mice; Mice, Inbred ICR; Morphine; Narcotics; Pain Measurement; Proglumide; Pyrrolidines; Receptors, Cholecystokinin; Sincalide | 1995 |
Effect of the selective CCKB receptor antagonist LY288513 on conditioned fear stress in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Fear; Hormone Antagonists; Male; Proglumide; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Stress, Physiological | 1996 |
Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells.
Topics: Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzodiazepinones; Calcium; CHO Cells; Cricetinae; Devazepide; Dose-Response Relationship, Drug; Drug Synergism; Hormone Antagonists; Humans; Inositol Phosphates; Pertussis Toxin; Proglumide; Receptors, Purinergic P1; Receptors, Serotonin; Sincalide; Virulence Factors, Bordetella | 1996 |
Involvement of supraspinal and spinal CCK receptors in the modulation of antinociception induced by cold water swimming stress in the mouse.
Topics: Animals; Brain; Cold Temperature; Hormone Antagonists; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Meglumine; Mice; Mice, Inbred ICR; Pain; Proglumide; Receptors, Cholecystokinin; Spinal Cord; Stress, Physiological; Swimming | 1996 |
Effect of cholecystokinin and related peptides on jejunal transepithelial hexose transport in the Sprague-Dawley rat.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Cholecystokinin; Glucose; Hormone Antagonists; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Male; Perfusion; Proglumide; Rats; Rats, Sprague-Dawley; Sincalide; Tetragastrin; Tetrodotoxin | 1996 |
Full and partial agonist activity of C-terminal cholecystokinin peptides at the cloned human CCK-A receptor expressed in Chinese hamster ovary cells.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Devazepide; Hormone Antagonists; Humans; Hydrogen-Ion Concentration; Pentagastrin; Peptide Fragments; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Sincalide; Tetragastrin | 1997 |
Reversal of tolerance to the antitransit effects of morphine during acute intestinal inflammation in mice.
Topics: Acute Disease; Animals; Cholecystokinin; Dizocilpine Maleate; Drug Tolerance; Enteritis; Gastrointestinal Transit; Male; Mice; Morphine; Proglumide; Receptors, N-Methyl-D-Aspartate | 1997 |
Effects of cholecystokinin-B receptor antagonist on dopamine system in tenascin mutant mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Hyperkinesis; Indoles; Meglumine; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Proglumide; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Synaptic Transmission; Tenascin; Tyrosine 3-Monooxygenase | 1997 |
Pentobarbital antagonism of morphine analgesia mediated by spinal cholecystokinin.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Indoles; Male; Meglumine; Mice; Morphine; Pentobarbital; Proglumide; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spinal Cord | 1998 |
Partitioning psychological and physical sources of transport-related stress in young cattle.
Topics: Animals; Anti-Anxiety Agents; Anti-Ulcer Agents; Anxiety; Benzamides; Cattle; Cattle Diseases; Cholecystokinin; Habituation, Psychophysiologic; Heart Rate; Hormone Antagonists; Indoles; Male; Meglumine; Proglumide; Stress, Physiological; Stress, Psychological; Transportation | 1998 |
Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats.
Topics: Amphetamines; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Hormone Antagonists; Indoles; Male; Meglumine; Proglumide; Rats; Rats, Sprague-Dawley | 1998 |
Fats and satiety: the role of the small intestine.
Topics: Animals; Cholecystokinin; Dietary Fats; Energy Intake; Fat Emulsions, Intravenous; Hormone Antagonists; Intestine, Small; Proglumide; Rats; Satiety Response | 1998 |
[Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety].
Topics: Animals; Anxiety; Biogenic Monoamines; Brain; Cholecystokinin; Disease Models, Animal; Hormone Antagonists; Male; Proglumide; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Effect of deramciclane, a new 5-HT receptor antagonist, on cholecystokinin-induced changes in rat gastrointestinal function.
Topics: Animals; Camphanes; Cholecystokinin; Digestive System; Gallbladder Emptying; Gastric Emptying; Giant Cell Arteritis; Hormone Antagonists; Male; Mice; Pancreas; Proglumide; Rats; Rats, Wistar; Serotonin Antagonists | 1999 |
Antianalgesic action of dynorphin A mediated by spinal cholecystokinin.
Topics: Analgesia; Analgesics; Animals; Antibodies; Cholecystokinin; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Injections, Spinal; Male; Meglumine; Mice; Morphine; Proglumide; Receptors, Cholecystokinin; Receptors, Opioid, delta; Spinal Cord | 1999 |
Supraspinal neurotensin-induced antianalgesia in mice is mediated by spinal cholecystokinin.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Hormone Antagonists; Immune Sera; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Meglumine; Mice; Morphine; Neurotensin; Proglumide; Receptors, Cholecystokinin | 1999 |
Differential role of cholecystokinin receptor subtypes in opioid modulation of ongoing maternal behavior.
Topics: Animals; Benzodiazepinones; Female; Hormone Antagonists; Lactation; Maternal Behavior; Morphine; Narcotics; Phenylurea Compounds; Proglumide; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1999 |
The role of brain-gut peptides in the control of sodium appetite.
Topics: Animals; Appetite; Bombesin; Brain; Captopril; Cholecystokinin; Digestive System Physiological Phenomena; Furosemide; Hormone Antagonists; Proglumide; Receptors, Cholecystokinin; Sincalide; Sodium, Dietary | 1999 |
Effects of lorglumide and atropine on MgSO(4)-induced gallbladder emptying in conscious dogs.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Gallbladder; Hormone Antagonists; Magnesium Sulfate; Methylcellulose; Muscarinic Antagonists; Muscle Contraction; Proglumide; Ultrasonography | 2000 |
Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats.
Topics: Amino Acids; Animals; Blood Glucose; Caseins; Cholecystokinin; Diet; Dietary Proteins; Eating; Feces; Insulin; Insulin-Like Growth Factor I; Intestines; Male; Naloxone; Naltrexone; Narcotic Antagonists; Proglumide; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Soybean Proteins; Stomach | 2001 |
Effect of three nonpeptide cholecystokinin antagonists on human isolated gallbladder.
Topics: Cholecystokinin; Gallbladder; Hormone Antagonists; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pentanoic Acids; Proglumide | 2001 |
CCK1 central receptor antagonist prevented the intestinal stress symptoms in sheep.
Topics: Animals; Catheterization; Cerebral Ventricles; Duodenum; Electromyography; Gastrointestinal Motility; Hormone Antagonists; Hydrocortisone; Proglumide; Sheep | 2002 |
Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disease Models, Animal; Estradiol; Female; Gastric Emptying; Gastrointestinal Transit; Hormone Antagonists; Ovariectomy; Phenylurea Compounds; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Time Factors | 2002 |
Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis.
Topics: Animals; Dose-Response Relationship, Drug; Fever; Gene Deletion; Hormone Antagonists; Lipopolysaccharides; Male; Mutagenesis; Proglumide; Rats; Rats, Inbred OLETF; Rats, Mutant Strains; Rats, Wistar; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Satiety Response; Sincalide | 2003 |
Effect of Dai-kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice.
Topics: Acetylcholine; Administration, Oral; Animals; Brain; Chlorpromazine; Dopamine; Drug Interactions; Gastric Emptying; Intestines; Male; Mice; Mice, Inbred ICR; Panax; Peristalsis; Pharmaceutical Preparations; Plant Extracts; Proglumide; Zanthoxylum; Zingiberaceae | 2003 |
Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Female; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Transit; Hormone Antagonists; Oxytocin; Phenylurea Compounds; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Vasotocin | 2003 |
Cholecystokinin reduces ethanol consumption in golden hamsters.
Topics: Alcohol Drinking; Animals; Cholecystokinin; Cricetinae; Depression, Chemical; Devazepide; Dose-Response Relationship, Drug; Glucose; Hormone Antagonists; Male; Mesocricetus; Proglumide; Receptors, Cholecystokinin | 2003 |
Enterostatin inhibition of dietary fat intake is dependent on CCK-A receptors.
Topics: 3T3 Cells; Animals; Brain; Colipases; Dietary Fats; Enzyme Precursors; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Proglumide; Protein Precursors; Rats; Rats, Inbred Strains; Receptor, Cholecystokinin A; Receptors, Cholecystokinin | 2003 |
Circulating ethanol does not stimulate pancreatic secretion in conscious rats.
Topics: Animals; Consciousness; Dose-Response Relationship, Drug; Duodenum; Esters; Ethanol; Gabexate; Guanidines; Infusions, Intravenous; Infusions, Parenteral; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Time Factors | 2003 |
Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Hormone Antagonists; Immunohistochemistry; Indoles; Male; Maze Learning; Meglumine; Microinjections; Neurons; Periaqueductal Gray; Proglumide; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Sincalide; Superior Colliculi; Time Factors | 2004 |
Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin.
Topics: Animals; Cholecystokinin; Culture Techniques; Duodenum; Food Deprivation; Hormone Antagonists; Humans; Immunohistochemistry; In Situ Hybridization; Male; Nerve Crush; Neurons, Afferent; Nodose Ganglion; Proglumide; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptor, Cholecystokinin A; Reverse Transcriptase Polymerase Chain Reaction; Satiety Response; Stomach; Vagus Nerve | 2004 |
Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Brain; Chemokines; Chemokines, CC; Cholecystokinin; Male; Maze Learning; Proglumide; Pyrazoles; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Species Specificity; Tetragastrin | 2004 |
Suppression of food intake by GI fatty acid infusions: roles of celiac vagal afferents and cholecystokinin.
Topics: Action Potentials; Animals; Cholecystokinin; Digestive System; Eating; Energy Intake; Fatty Acids; Hormone Antagonists; Infusions, Parenteral; Male; Proglumide; Rats; Rats, Sprague-Dawley; Sincalide; Time Factors; Vagotomy; Vagus Nerve | 2004 |
Cholecystokinin-induced satiety is mediated through interdependent cooperation of CCK-A and 5-HT3 receptors.
Topics: Animals; Cholecystokinin; Eating; Hormone Antagonists; Male; Ondansetron; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Serotonin, 5-HT3; Satiety Response; Serotonin Antagonists | 2004 |
Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.
Topics: Acute Disease; alpha-Amylases; Animals; Binding, Competitive; Cerebral Cortex; Cholecystokinin; Devazepide; Disease Models, Animal; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neuromuscular Junction; Pancreatitis; Peptide Fragments; Proglumide; Pyrimidinones; Rats; Rats, Wistar; Receptor, Cholecystokinin A | 2004 |
Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Membrane; Female; Lipopolysaccharides; Macrophages, Alveolar; Proglumide; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; RNA, Messenger; Sincalide; Up-Regulation | 2004 |
Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats.
Topics: Animals; Beverages; Body Weight; Cholecystokinin; Drinking; Eating; Gastric Emptying; Gastrointestinal Motility; Hormone Antagonists; Male; Metabolism; Morinda; Proglumide; Rats; Rats, Sprague-Dawley | 2004 |
Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids.
Topics: Animals; Cell Count; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Green Fluorescent Proteins; Hormone Antagonists; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Mice; Mice, Transgenic; Narcotics; Neurons; Patch-Clamp Techniques; Pro-Opiomelanocortin; Proglumide; Proto-Oncogene Proteins c-fos; Quinoxalines; Solitary Nucleus; Time Factors; Visceral Afferents | 2005 |
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
Topics: Animals; Appetite; Avoidance Learning; Capsaicin; Conditioning, Psychological; Energy Metabolism; Feeding Behavior; Hormone Antagonists; Hot Temperature; Housing, Animal; Imidazoles; Injections, Intraperitoneal; Male; Motor Activity; Proglumide; Pyrimidines; Rats; Rats, Long-Evans; Sodium; Space Perception; Taste | 2005 |
Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Biotin; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Glutamic Acid; Hormone Antagonists; Imaging, Three-Dimensional; Immunohistochemistry; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Peptides; Proglumide; Rats; Rats, Sprague-Dawley; Sincalide; Solitary Nucleus; Synaptic Transmission; Tetrodotoxin; Tyrosine 3-Monooxygenase | 2005 |
Cholecystokinin1 receptors mediate the increase in Fos-like immunoreactivity in the rat myenteric plexus following intestinal oleate infusion.
Topics: Animals; Cell Count; Diagnostic Imaging; Drug Interactions; Hormone Antagonists; Immunohistochemistry; Intestines; Male; Myenteric Plexus; Neurons; Oleic Acid; Proglumide; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin | 2005 |
Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Devazepide; Dose-Response Relationship, Drug; Drug Synergism; Gastrins; Growth Inhibitors; HT29 Cells; Humans; Melatonin; Proglumide; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Sincalide | 2005 |
Effect of cholecystokinin octapeptide on diacylglycerol-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide.
Topics: Animals; Benzodiazepines; Cell Membrane; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Female; Isoenzymes; Lipopolysaccharides; Macrophages, Alveolar; Proglumide; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Signal Transduction; Sincalide | 2005 |
Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Estrogens; Female; Hormone Antagonists; Ovariectomy; Proglumide; Protein Binding; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Cholecystokinin; Receptors, Opioid, mu; Sincalide; Tritium | 2006 |
[Receptor mechanisms underlying the modulation of lipopolysaccharide-induced nuclear factor-kappaB expression in vascular endothelial cells by cholecystokinin octapeptide].
Topics: Benzodiazepines; Cells, Cultured; Endothelial Cells; Humans; Lipopolysaccharides; NF-kappa B; Proglumide; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Sincalide; Umbilical Veins | 2006 |
Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Brain; Brain Chemistry; Chylomicrons; Fat Emulsions, Intravenous; Hormone Antagonists; Hypothalamus; Immunohistochemistry; Intubation, Gastrointestinal; Lipids; Lymph; Male; Neurons; Paraventricular Hypothalamic Nucleus; Poloxamer; Proglumide; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Solitary Nucleus; Surface-Active Agents; Ventromedial Hypothalamic Nucleus | 2007 |
Enterostatin (APGPR) enhances memory consolidation in mice.
Topics: Administration, Oral; Animals; Avoidance Learning; Colipases; Enzyme Precursors; Injections, Intraventricular; Male; Memory; Mice; Proglumide; Protein Precursors; Receptor, Cholecystokinin A | 2007 |
The effect of luminal ghrelin on pancreatic enzyme secretion in the rat.
Topics: Amylases; Animals; Capsaicin; Cholecystokinin; Duodenum; Ghrelin; Humans; Male; Pancreas; Peptide Hormones; Proglumide; Radioimmunoassay; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Vagotomy | 2007 |
Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion.
Topics: Animals; Autonomic Fibers, Preganglionic; Brain Stem; Capsaicin; Caseins; Hormone Antagonists; Microinjections; Pancreas, Exocrine; Paracrine Communication; Proglumide; Proteins; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Sincalide; Vagotomy; Vagus Nerve | 2007 |
Cholecystokinin-8s excites identified rat pancreatic-projecting vagal motoneurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Autonomic Fibers, Preganglionic; Brain Stem; Calcium; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Hormone Antagonists; Motor Neurons; Pancreas; Pancreatic Polypeptide; Patch-Clamp Techniques; Potassium; Potassium Channels, Calcium-Activated; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Sincalide; Tetrodotoxin; Vagus Nerve | 2007 |
Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.
Topics: Animals; Antioxidants; Apolipoproteins A; Appetite Depressants; Dose-Response Relationship, Drug; Feeding Behavior; Hormone Antagonists; Intestine, Small; Male; Proglumide; Rats; Rats, Sprague-Dawley; Sincalide; Time Factors | 2007 |
Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary.
Topics: Animals; Cell Count; Estradiol; Estrogen Receptor alpha; Female; Gonadotrophs; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovariectomy; Pituitary Gland; Pituitary Gland, Anterior; Proestrus; Proglumide; Receptor, Cholecystokinin A; RNA, Messenger | 2007 |
Parasympathetic non-adrenergic, non-cholinergic transmission in rat parotid glands: effects of cholecystokinin-A and -B receptor antagonists on the secretory response.
Topics: Animals; Female; Hormone Antagonists; Parasympathetic Nervous System; Parotid Gland; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Saliva | 2008 |
Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Eating; Female; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Transit; Ovariectomy; Oxytocin; Phenylurea Compounds; Proglumide; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Receptors, Oxytocin; Sincalide; Vasotocin | 2008 |
Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Duodenum; Male; Melatonin; Pancreas, Exocrine; Pancreatic Juice; Proglumide; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Tryptophan; Vagotomy; Vagus Nerve | 2007 |
The endogenous CCK mediation of electroacupuncture stimulation-induced satiety in rats.
Topics: Animals; Cholecystokinin; Electroacupuncture; Fasting; Male; Proglumide; Rats; Rats, Inbred OLETF; Rats, Sprague-Dawley; Satiation | 2008 |
Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors.
Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Esophagectomy; Female; Gastrins; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Myocytes, Smooth Muscle; Proglumide; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Sincalide | 2008 |
Melatonin-evoked in vivo secretion of protein and amylase from the parotid gland of the anaesthetised rat.
Topics: Amylases; Analysis of Variance; Anesthesia; Animals; Autonomic Denervation; Blotting, Western; Female; Melatonin; Methacholine Chloride; Nitric Oxide Synthase; Parotid Gland; Pentobarbital; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Saliva; Salivary Proteins and Peptides; Tryptamines | 2008 |
Localization of CCK-1R in the omasum and role of CCK in the regulation of omasal contractions in sheep.
Topics: Animals; Atropine; Electromyography; Hormone Antagonists; In Vitro Techniques; Indoles; Meglumine; Muscle Contraction; Omasum; Proglumide; Receptors, Cholecystokinin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sheep; Sincalide; Tetrodotoxin | 2008 |
Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach.
Topics: Animals; Behavior, Animal; Cells, Cultured; Cholagogues and Choleretics; Cholecystokinin; Fasting; Gene Expression Regulation; Hormone Antagonists; Humans; Male; Mice; Mice, Knockout; Neurons, Afferent; Nodose Ganglion; Oncogene Proteins v-fos; Proglumide; Rats; Receptor, Cholecystokinin A; Receptors, Neuropeptide Y; RNA, Messenger; Satiety Response; Stomach; Vagus Nerve | 2008 |
Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats.
Topics: alpha-Amylases; Animals; Blood Glucose; Body Weight; Cholecystokinin; Drug Interactions; Eating; Energy Intake; Intestines; Male; Microvilli; Phaseolus; Plant Extracts; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin | 2009 |
Gastric leptin: a novel role in cardiovascular regulation.
Topics: Adipose Tissue; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cholecystokinin; Gastric Mucosa; Heart Rate; Hormone Antagonists; Infusions, Intra-Arterial; Infusions, Intravenous; Leptin; Male; Medulla Oblongata; Models, Animal; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sympathetic Nervous System | 2010 |
Electroacupuncture induces Fos expression in the nucleus tractus solitarius via cholecystokinin A receptor signaling in rats.
Topics: Animals; Eating; Electroacupuncture; Fasting; Fluorescent Antibody Technique; Hormone Antagonists; Male; Neurons; Proglumide; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Signal Transduction; Solitary Nucleus | 2010 |
Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin B1 Receptor Antagonists; Brassica rapa; Hypotension; Indomethacin; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Plant Proteins; Proglumide; Quinazolinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Bradykinin B1; Receptor, Cholecystokinin A; Receptors, Prostaglandin; Vasodilation | 2010 |
Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland.
Topics: Animals; Anti-Inflammatory Agents; Escherichia coli; Hormone Antagonists; Injections, Intraperitoneal; Lipopolysaccharides; Lysine; Melatonin; Neutrophil Infiltration; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Organ Size; Parasympathectomy; Parotid Gland; Parotitis; Peroxidase; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Melatonin, MT2; Sincalide; Sympathectomy; Tryptamines | 2010 |
CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats.
Topics: Animals; Cholecystokinin; Duodenum; Gastrointestinal Motility; Male; Muscle Contraction; Myenteric Plexus; Oxytocin; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Receptors, Oxytocin; Tetrodotoxin; Vasotocin | 2010 |
Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition.
Topics: Animals; Anorexia; Benzoxazines; Brain; Drug Synergism; Feeding Behavior; Gene Expression; Genes, fos; Male; Morpholines; Naphthalenes; Piperidines; Proglumide; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Sincalide | 2011 |
Development and validation of an LC-MS/MS-ESI method for the determination of lorglumide, a CCK-1 antagonist in mouse plasma: application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Hormone Antagonists; Linear Models; Male; Mice; Mice, Inbred C57BL; Phenacetin; Proglumide; Receptors, Cholecystokinin; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Potential of the gastric motility drug lorglumide in prostate cancer imaging.
Topics: Cell Line, Tumor; Contrast Media; Flow Cytometry; Fluorescent Dyes; Gastrointestinal Agents; Gastrointestinal Motility; Glioma; Humans; Magnetic Resonance Imaging; Male; Microscopy, Confocal; Osteosarcoma; Proglumide; Prostatic Neoplasms; Rhodamines | 2012 |
Morphological evidence that pentagastrin regulates secretion in the human parotid gland.
Topics: Acinar Cells; Gastrointestinal Agents; Hormone Antagonists; Humans; Microscopy, Electron; Microvilli; Parotid Gland; Pentagastrin; Proglumide | 2012 |
Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cholecystokinin; Dipeptides; Eating; Enteroendocrine Cells; Enzyme Inhibitors; Indomethacin; Male; Mesenteric Arteries; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Proglumide; Prostaglandins; Rats; Rats, Inbred SHR; Receptors, Cholecystokinin; Vasodilator Agents | 2012 |
Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats.
Topics: Animals; Cholecystokinin; Chorionic Gonadotropin; Female; Gastric Emptying; Gastrointestinal Transit; Hormone Antagonists; Ovariectomy; Proglumide; Rats; Rats, Sprague-Dawley | 2013 |
The long chain fatty acid oleate activates mouse intestinal afferent nerves in vitro.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Chemokines, CC; Enteroendocrine Cells; Intestinal Mucosa; Jejunum; Male; Mice; Nerve Fibers; Neurons, Afferent; Nicardipine; Oleic Acid; Perfusion; Proglumide; Receptors, Cholecystokinin; Vagotomy; Vagus Nerve | 2013 |
Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats.
Topics: Animals; Appetite Depressants; Dose-Response Relationship, Drug; Eating; Ginsenosides; Glucose; Hormone Antagonists; Injections, Intraperitoneal; Male; Neurons, Afferent; Proglumide; Rats, Long-Evans; Receptor, Cholecystokinin A; Satiation; Sincalide; Vagus Nerve | 2015 |
Postsynaptic Depolarization Enhances GABA Drive to Dorsomedial Hypothalamic Neurons through Somatodendritic Cholecystokinin Release.
Topics: Animals; Animals, Newborn; Cholecystokinin; Dorsomedial Hypothalamic Nucleus; GABA Agents; gamma-Aminobutyric Acid; Guanosine Diphosphate; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Peptides; Proglumide; Quinazolinones; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Signal Transduction; Synaptosomal-Associated Protein 25; Thionucleotides | 2015 |
CCK reduces the food intake mainly through CCK1R in Siberian sturgeon (Acipenser baerii Brandt).
Topics: Animals; Apelin; Cholecystokinin; Eating; Fasting; Feeding Behavior; Fishes; Nerve Tissue Proteins; Peptide YY; Proglumide; Quinazolinones | 2017 |
UCN3 suppresses food intake in coordination with CCK and the CCK2R in Siberian sturgeon (Acipenser baerii).
Topics: Animals; Eating; Fishes; Proglumide; Receptor, Cholecystokinin B; Urocortins | 2019 |
Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.
Topics: Aging; Amino Acid Sequence; Animals; Antihypertensive Agents; Blood Pressure; Cholecystokinin; Dipeptides; Drug Evaluation, Preclinical; Hypertension; Male; Mesenteric Arteries; Nitric Oxide; Peptide Library; Proglumide; Rats; Rats, Inbred SHR; Receptors, Cholecystokinin; Vasodilation; Vasodilator Agents | 2019 |