prodiginine and butylcycloheptylprodigiosin

prodiginine has been researched along with butylcycloheptylprodigiosin* in 2 studies

Other Studies

2 other study(ies) available for prodiginine and butylcycloheptylprodigiosin

ArticleYear
Butylcycloheptylprodigiosin and undecylprodigiosin are potential photosensitizer candidates for photodynamic cancer therapy.
    Molecular biology reports, 2021, Volume: 48, Issue:8

    Prodiginines are bacterial red polypyrrole pigments and multifaceted secondary metabolites. These agents have anti-proliferative, immunosuppressive, antimicrobial, and anticancer effects. Recent analysis revealed that prodigiosin hypersensitizes Serratia marcescens to gamma radiation. In the present study, we report the cytotoxicity and genotoxicity properties of undecylprodigiosin and butylcycloheptylprodigiosin in the presence and absence of radiation through the MTT and alkaline comet experiments.. Findings demonstrated that undecylprodigiosin was at least a fivefold more cytotoxic at low radiation doses (1 and 3 Gy) on both MCF7 and HDF lines rather than in the absence or high radiation doses (5 Gy) (P value < 0.05). Although butylcycloheptylprodigiosin toxicity on MCF7 and HDF was dose-dependent, it was not influenced by any radiation doses (P value > 0.05). Comet findings confirmed that these compounds' genotoxicity is only dose-dependent. Radiation had no significant effects on DNA damage on any of the cells (P value > 0.05).. In general, it can be concluded that the prodiginines are cytotoxic agents that act as a double-edged sword, radiosensitizers and radio-protective, respectively at low and high radiation doses in cancer treatment process. As the results they could be used in antitumor therapies very soon.

    Topics: Anti-Infective Agents; Antineoplastic Agents; Cell Line; DNA Damage; Humans; Immunosuppressive Agents; MCF-7 Cells; Neoplasms; Photosensitizing Agents; Prodigiosin

2021
Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in
    Journal of natural products, 2020, 01-24, Volume: 83, Issue:1

    Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (

    Topics: Biological Products; Ion Mobility Spectrometry; Molecular Structure; Prodigiosin; Streptomyces coelicolor

2020