procainamide 4-hydroxylamine has been researched along with procainamide in 11 studies
| Studies (procainamide 4-hydroxylamine) | Trials (procainamide 4-hydroxylamine) | Recent Studies (post-2010) (procainamide 4-hydroxylamine) | Studies (procainamide) | Trials (procainamide) | Recent Studies (post-2010) (procainamide) |
|---|---|---|---|---|---|
| 12 | 0 | 0 | 3,612 | 174 | 122 |
| Protein | Taxonomy | procainamide 4-hydroxylamine (IC50) | procainamide (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | 3.9 | |
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | 1 | |
| Acetylcholinesterase | Homo sapiens (human) | 1 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.5 | |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | 1 | |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | 7.35 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, LE; Carter, JM; Donovan-Brand, RJ; Hess, EV; Roberts, SM; Wheeler, JF; Zimmer, HW | 1 |
| Adams, L; Heineman, WR; Hess, EV; Lunte, CE; Wheeler, JF | 1 |
| Gill, EW; Jones, A; Sim, E; Stanley, L | 1 |
| Adams, LE; Budinsky, R; Donovan-Brand, R; Hess, EV; Roberts, SM; Skoulis, NP; Zimmer, H | 1 |
| Curnutte, JT; Rubin, RL | 1 |
| Adams, LE; Budinsky, RA; Donovan-Brand, R; Hess, EV; Roberts, SM; Sanders, CE | 1 |
| Gleichmann, E; Goebel, C; Goebels, R; Kubicka-Muranyi, M; Uetrecht, J | 1 |
| Duncan, SR; Kretz-Rommel, A; Rubin, RL | 1 |
| Kretz-Rommel, A; Rubin, RL | 3 |
1 review(s) available for procainamide 4-hydroxylamine and procainamide
| Article | Year |
|---|---|
A nondeletional mechanism for central T-cell tolerance.
Topics: Animals; Autoimmunity; Clonal Deletion; Humans; Immune Tolerance; Lupus Vulgaris; Mice; Procainamide; Receptors, Antigen, T-Cell; T-Lymphocytes; Thymus Gland | 2001 |
10 other study(ies) available for procainamide 4-hydroxylamine and procainamide
| Article | Year |
|---|---|
Effects of procainamide hydroxylamine on generation of reactive oxygen species by macrophages and production of cytokines.
Topics: Animals; Free Radicals; In Vitro Techniques; Interleukin-1; Macrophages; Male; Mice; Mice, Inbred C3H; Oxygen; Procainamide; Rats; Rats, Inbred Lew | 1990 |
Electrochemical determination of N-oxidized procainamide metabolites and functional assessment of effects on murine cells in vitro.
Topics: Acecainide; Animals; Ascorbic Acid; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; Cysteine; DNA; Electrochemistry; Electrolysis; Glutathione; Hydrogen-Ion Concentration; Kinetics; Mice; Oxidation-Reduction; Procainamide; Rats; Spectrophotometry; Spleen | 1988 |
Metabolites of procainamide and practolol inhibit complement components C3 and C4.
Topics: Acecainide; Complement C3; Complement C4; Humans; Practolol; Procainamide; Protein Binding | 1988 |
Procainamide hydroxylamine lymphocyte toxicity--I. Evidence for participation by hemoglobin.
Topics: Acecainide; Animals; Ascorbic Acid; Carbon Monoxide; Chemical Phenomena; Chemistry; Hemoglobins; In Vitro Techniques; Liver; Lymphocytes; Male; Methemoglobin; Monocytes; Procainamide; Rats; Rats, Inbred Strains; Spleen; Thymidine | 1989 |
Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro.
Topics: Adult; B-Lymphocytes; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Female; Humans; Hydrogen Peroxide; Hypochlorous Acid; Male; Neutrophils; Oxygen Consumption; Phagocytosis; Procainamide | 1989 |
Immunomodulatory effects of procainamide metabolites: their implications in drug-related lupus.
Topics: Adult; Female; Hemoglobins; Humans; Immunoglobulins; Interleukin-1; Latex; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Lymphocytes; Macrophages; Male; Microsomes, Liver; Middle Aged; Mitogens; Monocytes; Phagocytosis; Procainamide; Superoxides | 1989 |
T lymphocytes ignore procainamide, but respond to its reactive metabolites in peritoneal cells: demonstration by the adoptive transfer popliteal lymph node assay.
Topics: Acecainide; Acetylation; Animals; Female; Humans; Hydroxylation; Immunologic Memory; Lymph Nodes; Mice; Mice, Inbred A; Mice, Inbred C57BL; Peritoneal Cavity; Phagocytes; Procainamide; Spleen; T-Lymphocytes | 1993 |
Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus.
Topics: Adoptive Transfer; Animals; Antibodies, Antinuclear; Autoimmunity; Disease Models, Animal; Female; Humans; Immune Tolerance; Immunity, Cellular; In Vitro Techniques; Lupus Erythematosus, Systemic; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred MRL lpr; Mice, Inbred NZB; Procainamide; T-Lymphocytes; Thymus Gland | 1997 |
Persistence of autoreactive T cell drive is required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus.
Topics: Adoptive Transfer; Age Factors; Animals; Antibodies, Antinuclear; Autoantigens; Chromatin; Disease Models, Animal; fas Receptor; Female; Immunization; Injections, Intralymphatic; Lupus Vulgaris; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred MRL lpr; Mice, Mutant Strains; Procainamide; T-Lymphocytes; Thymus Gland | 1999 |
Disruption of positive selection of thymocytes causes autoimmunity.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Antigen-Presenting Cells; Autoimmune Diseases; Autoimmunity; Columbidae; Cytochrome c Group; Immune Tolerance; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Mice, Transgenic; Molecular Sequence Data; Organ Culture Techniques; Peptide Fragments; Procainamide; Receptors, Antigen, T-Cell; T-Lymphocyte Subsets; T-Lymphocytes; Thymus Gland | 2000 |