Page last updated: 2024-08-16

probenecid and zidovudine

probenecid has been researched along with zidovudine in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (5.45)	18.7374
1990's	25 (45.45)	18.2507
2000's	17 (30.91)	29.6817
2010's	9 (16.36)	24.3611
2020's	1 (1.82)	2.80

Authors

Authors	Studies
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Kamali, F; Rawlins, MD	1
Ellis-Pegler, RB; Kennedy, J; McDermott, J; Thomas, MG	1
Hedaya, MA; Sawchuk, RJ; Wong, SL	1
Bidault, R; Haumont, M; Herber, R; Magdalou, J; Siest, G; van Es, H	1
Balboa, A; Bauer, MR; Dixon, KF; Gerber, N; Mays, DC; Nawoot, S; Pawluk, LJ	1
Finco, TS; Gallo, JM; Mehta, M; Qian, MX; Viswanathan, CT	1
Anderson, DC; Cretton, EM; McClure, HM; Schinazi, RF; Sommadossi, JP	1
Finco, TS; Gallo, JM; Qian, MX	1
Cretton, EM; Sommadossi, JP	1
Kornhauser, DM; Lietman, PS; Petty, BG	1
Contreras, G; Duckworth, AS; Duckworth, GW; Henderson, G	1
Hedaya, MA; Sawchuk, RJ	2
Elmquist, WF; Hedaya, MA; Sawchuk, RJ	1
Bartlett, JG; Hendrix, CW; Kornhauser, DM; Lietman, PS; Nerhood, LJ; Petty, BG; Woods, AS	1
Blum, MR; Broder, S; de Miranda, P; Good, SS; Myers, CE; Thomas, RV; Yarchoan, R	1
al-Habet, SM; Nosbisch, C; Tsai, CC; Unadkat, JD; Williamson, T	1
Aiba, T; Koizumi, T; Sakurai, Y; Tsukada, S	1
Hasegawa, T; Juni, K; Kawaguchi, T; Sato, N; Seki, T	1
Breimer, DD; de Boer, AG; Jaehde, U; Langemeijer, MW; Masereeuw, R	1
Sawchuk, RJ; Van Belle, K; Wong, SL	1
Cass, CE; Yao, SY; Young, JD	1
Sugiyama, Y; Suzuki, H; Takasawa, K; Terasaki, T	1
Sawchuk, RJ; Wang, Y; Wei, Y	1
Casserella, S; Cimoch, PJ; Griffy, KG; Jung, D; Lavelle, J; Pollard, R; Tarnowski, TL; Wong, R	1
Motohashi, M; Nakagawa, Y; Okuda, T	1
Jin, Y; Juni, K; Morimoto, Y; Seki, T	1
Elmquist, WF; Sawchuk, RJ	1
Cha, SH; Endou, H; Khamdang, S; Kimura, H; Kobayashi, Y; Narikawa, S; Sekine, T; Takeda, M; Yamamoto, T	1
Gibbs, JE; Thomas, SA	1
Becher, F; Benech, H; Clayette, P; Dereuddre-Bosquet, N; Dormont, D; Garrigues, A; Grassi, J; Jorajuria, S; Mabondzo, A; Martin, S; Orlowski, S; Porcheray, F	1

Reviews

5 review(s) available for probenecid and zidovudine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Microdialysis in the study of drug transporters in the CNS. Advanced drug delivery reviews, 2000, Dec-15, Volume: 45, Issue:2-3 Topics: Animals; Biological Transport; Brain; Colchicine; Etoposide; Humans; Microdialysis; Morphine; Probenecid; Rhodamines; Zidovudine	2000

Trials

2 trial(s) available for probenecid and zidovudine

Article	Year
Probenecid and zidovudine metabolism. Lancet (London, England), 1989, Aug-26, Volume: 2, Issue:8661 Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; AIDS-Related Complex; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Patient Compliance; Probenecid; Quinine; Zidovudine	1989
Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Mar-01, Volume: 17, Issue:3 Topics: Administration, Oral; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Didanosine; Drug Interactions; Female; Ganciclovir; Half-Life; HIV Infections; Humans; Male; Probenecid; Renal Agents; Zidovudine	1998

Article

Year

Probenecid and zidovudine metabolism.

Lancet (London, England), 1989, Aug-26, Volume: 2, Issue:8661

Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; AIDS-Related Complex; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Patient Compliance; Probenecid; Quinine; Zidovudine

1989

Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Mar-01, Volume: 17, Issue:3

Topics: Administration, Oral; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Didanosine; Drug Interactions; Female; Ganciclovir; Half-Life; HIV Infections; Humans; Male; Probenecid; Renal Agents; Zidovudine

1998

Other Studies

48 other study(ies) available for probenecid and zidovudine

Article	Year
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Influence of probenecid and paracetamol (acetaminophen) on zidovudine glucuronidation in human liver in vitro. Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:6 Topics: Acetaminophen; Adult; Aged; Glucuronates; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Middle Aged; Probenecid; Zidovudine	1992
Pharmacokinetics of zidovudine plus probenecid. The Journal of infectious diseases, 1992, Volume: 166, Issue:3 Topics: Drug Therapy, Combination; HIV Infections; Humans; Male; Probenecid; Zidovudine	1992
Competitive inhibition of zidovudine clearance by probenecid during continuous coadministration. Pharmaceutical research, 1992, Volume: 9, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Drug Interactions; Infusions, Intravenous; Male; Models, Biological; Probenecid; Rabbits; Zidovudine	1992
Glucuronidation of 3'-azido-3'-deoxythymidine in human liver microsomes: enzyme inhibition by drugs and steroid hormones. Biochimica et biophysica acta, 1992, Jun-09, Volume: 1139, Issue:1-2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Estrone; Ethinyl Estradiol; Flurbiprofen; Glucuronosyltransferase; Humans; Microsomes, Liver; Naproxen; Phenylpropionates; Probenecid; Testosterone; Zidovudine	1992
A nonprimate animal model applicable to zidovudine pharmacokinetics in humans: inhibition of glucuronidation and renal excretion of zidovudine by probenecid in rats. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:3 Topics: Animals; Bile; Bile Ducts; Depression, Chemical; Glucuronates; Injections, Intravenous; Male; Models, Biological; Probenecid; Rats; Rats, Inbred Strains; Spectrometry, Mass, Fast Atom Bombardment; Tritium; Zidovudine	1991
Pharmacokinetic evaluation of drug interactions with zidovudine. I: Probenecid and zidovudine in monkeys. Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:11 Topics: Animals; Drug Interactions; Injections, Intravenous; Intubation, Gastrointestinal; Macaca fascicularis; Male; Probenecid; Zidovudine	1991
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:5 Topics: Animals; Dideoxynucleosides; Drug Interactions; Glucuronates; Half-Life; Macaca mulatta; Probenecid; Zidovudine	1991
Rapid and simultaneous determination of zidovudine and its glucuronide metabolite in plasma and urine. Application to the pharmacokinetic interaction of zidovudine and probenecid in the monkey. Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:3 Topics: Animals; Chromatography, Liquid; Drug Interactions; Half-Life; Haplorhini; Probenecid; Zidovudine	1991
Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Acetaminophen; Animals; Body Fluid Compartments; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Drug Interactions; Humans; Liver; Probenecid; Rats; Rats, Inbred Strains; Zidovudine	1991
Zidovudine with probenecid: a warning. Lancet (London, England), 1990, Apr-28, Volume: 335, Issue:8696 Topics: Acquired Immunodeficiency Syndrome; Drug Interactions; Humans; Male; Probenecid; Product Surveillance, Postmarketing; Zidovudine	1990
Zidovudine with probenecid. Lancet (London, England), 1990, Aug-18, Volume: 336, Issue:8712 Topics: AIDS-Related Complex; Drug Eruptions; Drug Therapy, Combination; Humans; Probenecid; Zidovudine	1990
Modeling the enhanced uptake of zidovudine (AZT) into cerebrospinal fluid. 1. Effect of probenecid. Pharmaceutical research, 1990, Volume: 7, Issue:4 Topics: Animals; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Probenecid; Rabbits; Zidovudine	1990
Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers. Pharmaceutical research, 1990, Volume: 7, Issue:4 Topics: Adult; Blood Proteins; Drug Interactions; Glucuronates; Half-Life; Humans; Probenecid; Protein Binding; Zidovudine	1990
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:5 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Interactions; Drug Therapy, Combination; Half-Life; Humans; Male; Middle Aged; Probenecid; Regression Analysis; Zidovudine	1989
Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit. Journal of pharmaceutical sciences, 1989, Volume: 78, Issue:9 Topics: Animals; Chromatography, High Pressure Liquid; Glomerular Filtration Rate; Infusions, Intravenous; Injections, Intravenous; Probenecid; Rabbits; Zidovudine	1989
Interaction of zidovudine (azidothymidine) with isoprinosine and probenecid in Macaca fascicularis. Pharmaceutical research, 1994, Volume: 11, Issue:1 Topics: Animals; Drug Interactions; Glucuronates; Inosine Pranobex; Macaca fascicularis; Male; Probenecid; Zidovudine	1994
Effects of probenecid and cimetidine on the renal excretion of 3'-azido-3'-deoxythymidine in rats. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1 Topics: Animals; Biological Transport; Cimetidine; Epithelium; Kidney; Male; Metabolic Clearance Rate; Microvilli; Probenecid; Rats; Rats, Wistar; Zidovudine	1995
Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats. Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:8 Topics: Administration, Intranasal; Animals; Male; Nasal Mucosa; Probenecid; Rats; Rats, Wistar; Zidovudine	1994
In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors. Pharmaceutical research, 1994, Volume: 11, Issue:2 Topics: Analysis of Variance; Animals; Azides; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Central Nervous System; Deoxyglucose; Diffusion; Endothelium, Vascular; Injections, Intravenous; Injections, Intraventricular; Male; Probenecid; Rats; Rats, Wistar; Sodium Azide; Thymidine; Zidovudine	1994
Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2 Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Dialysis; Extracellular Space; Male; Models, Biological; Probenecid; Rabbits; Zidovudine	1993
Transport of the antiviral nucleoside analogs 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes. Molecular pharmacology, 1996, Volume: 50, Issue:2 Topics: Animals; Antiviral Agents; Biological Transport; Carrier Proteins; Dose-Response Relationship, Drug; Female; Intestinal Absorption; Membrane Proteins; Nucleoside Transport Proteins; Probenecid; Rats; Recombinant Proteins; Uridine; Xenopus laevis; Zalcitabine; Zidovudine	1996
In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1 Topics: Animals; Anti-HIV Agents; Biological Transport; Blood-Brain Barrier; Brain; Didanosine; Dose-Response Relationship, Drug; Inulin; Male; Probenecid; Rats; Rats, Wistar; Zidovudine	1997
Zidovudine transport within the rabbit brain during intracerebroventricular administration and the effect of probenecid. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:12 Topics: Animals; Anti-HIV Agents; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Injections, Intraventricular; Male; Microdialysis; Probenecid; Rabbits; Zidovudine	1997
Complete two-dimensional separation for analysis of acidic compounds in plasma using column-switching reversed-phase liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1999, Apr-16, Volume: 726, Issue:1-2 Topics: Acids; Animals; Calibration; Chromatography, Liquid; Probenecid; Rats; Reproducibility of Results; Zidovudine	1999
Effect of application volume of ethanol-isopropyl myristate mixed solvent system on permeation of zidovudine and probenecid through rat skin. Drug development and industrial pharmacy, 2000, Volume: 26, Issue:2 Topics: Administration, Cutaneous; Animals; Anti-HIV Agents; Ethanol; Male; Myristates; Permeability; Probenecid; Rats; Uricosuric Agents; Zidovudine	2000
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:3 Topics: Acyclovir; Anti-HIV Agents; Antiviral Agents; Biological Transport; Cells, Cultured; Ganciclovir; Humans; Kidney; Kinetics; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Renal Agents; Zidovudine	2002
The distribution of the anti-HIV drug, 2'3'-dideoxycytidine (ddC), across the blood-brain and blood-cerebrospinal fluid barriers and the influence of organic anion transport inhibitors. Journal of neurochemistry, 2002, Volume: 80, Issue:3 Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anti-HIV Agents; Blood-Brain Barrier; Capillaries; Carbon Radioisotopes; Choroid Plexus; Chromatography, High Pressure Liquid; Diuretics, Osmotic; Guinea Pigs; Herbicides; Mannitol; Octanols; Oligopeptides; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Perfusion; Probenecid; Sodium Chloride; Tritium; Uricosuric Agents; Zalcitabine; Zidovudine	2002
ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antiviral therapy, 2004, Volume: 9, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporins; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Leukocytes, Mononuclear; Macrophages; Multidrug Resistance-Associated Proteins; Probenecid; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Zidovudine	2004