probenecid has been researched along with verapamil in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.22) | 18.7374 |
| 1990's | 13 (14.44) | 18.2507 |
| 2000's | 47 (52.22) | 29.6817 |
| 2010's | 26 (28.89) | 24.3611 |
| 2020's | 2 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Aubé, J; Borchardt, RT; Gao, J; Murase, O; Schowen, RL | 1 |
| Belinsky, MG; Chen, ZS; Kruh, GD; Rea, PA; Zeng, H | 1 |
| Chen, ZS; Kruh, GD; Kuwano, M; Lee, K; Raftogianis, RB; Walther, S; Zeng, H | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Honda, Y; Koyabu, N; Kuwano, M; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Uchiumi, T; Ushigome, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Masseno, V; Muriithi, S; Nzila, A | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chan, KF; Chan, TH; Chow, LM; Lam, CY; Tsang, KH; Wong, IL; Zhao, Y | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Henderson, GB | 1 |
| Hedman, A | 1 |
| Henderson, GB; Strauss, BP | 1 |
| O'Leary, DF; Sirotnak, FM | 1 |
| Gale, GR; Hynes, JB; Smith, AB | 1 |
| Kolassa, N; Pfleger, K; Volkmer, I | 1 |
| Chardonnet, Y; Chignol, MC; Lizard, G; Schmitt, D | 1 |
| Flo, K; Hansen, M; Kjorstad, KE; Maltau, JM; Orbo, A; Sager, G | 1 |
| Fujita, T; Fukuzumi, M; Muranishi, S; Nishimaki, A; Yamada, H; Yamamoto, A | 1 |
| Aungst, BJ; Fujisaki, H; Miyazaki, K; Saitoh, H | 1 |
| Kildalsen, H; Sager, G; Schultz, C; Vaskinn, S | 1 |
| Aszalos, A; Weaver, JL | 1 |
| Courtois, A; Fardel, O; Guillouzo, A; Payen, L; Vernhet, L | 1 |
| Herceg, Z; Wesierska-Gadek, J; Wurzer, G | 1 |
| Grand-Perret, T; Issandou, M | 1 |
| Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; Nabulsi, L; van der Sandt, IC; Voorwinden, HH; Vos, CM | 1 |
| Baltrons, MA; García, A; Pedraza, CE | 1 |
| Fedrowitz, M; Löscher, W; Potschka, H | 1 |
| Cox, DS; Eddington, ND; Gao, H; Raje, S; Scott, KR | 1 |
| Anagnostopoulos, N; Androutsos, G; Galanopoulos, A; Kalmantis, T; Meletis, J; Paterakis, G; Rombos, Y; Sagriotis, A; Symeonidis, A; Tiniakou, M; Tsimberidou, AM; Yataganas, X; Zoumbos, N | 1 |
| Bandi, N; Kompella, UB | 1 |
| Taylor, EM; Yan, R | 1 |
| Crowe, A | 1 |
| Flexner, C; Hildreth, J; Speck, RR; Yu, XF | 1 |
| Buesen, R; Jacob, J; Lampen, A; Mock, M; Nau, H; Seidel, A | 1 |
| Boezeman, J; De Witte, T; Raaijmakers, HG; Raymakers, RA; Van Den Bosch, G | 1 |
| Chanteux, H; Michot, JM; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F | 1 |
| Beyer, TD; Dumitriu, IE; Gaipl, US; Herrmann, M; Kalden, JR; Roedel, F | 1 |
| Crowe, A; Wong, P | 1 |
| Grossmann, A; Hudson, FN; Kavanagh, TJ; Poot, M; Rabinovitch, PS | 1 |
| Baltes, S; Löscher, W; Potschka, H | 1 |
| Candussio, L; Crivellato, E; Damiani, D; Decorti, G; Giraldi, T; Klugmann, FB; Michelutti, A; Rosati, A | 1 |
| Sugawara, K; Tateishi, T; Uno, T; Yasui-Furukori, N | 1 |
| Caloni, F; De Angelis, I; Friggè, G; Raimondi, F; Stammati, A; Zucco, F | 1 |
| Bertrand, M; Boursier-Neyret, C; Fardel, O; Jigorel, E; Le Vee, M | 1 |
| Leader, JP; O'Donnell, MJ | 1 |
| Bertelsen, KM; Greenblatt, DJ; von Moltke, LL | 1 |
| Tian, X; Wang, K; Yang, X | 1 |
| Bruesewitz, C; Funke, A; Kuhland, U; Lipp, R; Wagner, T | 1 |
| Kurttila, T; Myllynen, P; Vähäkangas, K; Vaskivuo, L | 1 |
| Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Liu, PQ; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Jani, M; Kovács, B; Krajcsi, P; Lin, G; Zhang, L; Zuo, Z | 1 |
| Bridges, CC; Campos, I; Costa, F; Gonçalves, P; Keating, E; Lemos, C; Martel, F; Smith, SB | 1 |
| Cao, F; Guo, J; Ping, Q; Zhang, H | 1 |
| Bachmann, K; Bykowski, C; Dhananjeyan, M; Erhardt, P; Hacker, M; Katta, A; White, DB | 1 |
| Barletta, J; Bergström, M; Blomquist, G; Långström, B; Syvänen, S | 1 |
| Chatterjee, M; Mandal, G; Saha, P; Sarkar, A; Singh, N; Sundar, S | 1 |
| Kawami, M; Nagai, J; Otani, Y; Takano, M; Tanda, M; Yumoto, R | 1 |
| Kaku, T; Kato, Y; Liu, K; Liu, Q; Meng, Q; Sun, H; Wang, C | 1 |
| Imasaka, T; Kaneta, T; Mbuna, J | 1 |
| Davey, AK; Hong, T; Jin, Y; Jiping, W; Lei, C; Qian, W; Ruijuan, X; Xuefen, Y; Xueying, Z; Yanxiao, C | 1 |
| Kuo, YC; Lu, CH | 1 |
| Gabriel, S; Heinemann, U; Kovács, R; Raue, C | 1 |
| He, L; Ke, X; Tian, JL; Zhang, XY | 1 |
| Jakob, I; Molinas, A; Sicard, G | 1 |
| Duan, L; Hu, W; Li, G; Sun, Y; Yan, Y; Zhao, B | 1 |
| Fricker, G; Hülsermann, U; Lenhard, T; Martinez-Torres, F; Meyding-Lamadé, U | 1 |
| Abele, D; Bickmeyer, U; Dringen, R; Petters, C; Rivera-Ingraham, G; Tietje, K | 1 |
| Li, X; Lu, Y; Yin, Z; Yu, Y; Zhao, X | 1 |
| Cao, YC; Liang, XL; Liao, ZG; Yang, M; Zhao, GW; Zhao, LJ; Zhu, ML | 1 |
| Chen, Z; Han, J; Hu, T; Huang, C; Li, J; Ma, T; Zhang, L; Zhong, J | 1 |
| He, X; Jiang, CP; Li, H; Li, P; Song, ZJ; Yang, XL; Yang, ZL; Zhang, CF; Zhang, SL | 1 |
| Jung, JA; Parvez, MM; Shin, HJ; Shin, JG | 1 |
| Ke, XM; Wang, YH; Yang, RP; Zhang, CH | 1 |
| Bader, K; Ebner, T; Fromm, MF; Giessmann, T; Hauel, E; Hohl, K; Ishiguro, N; Jambrecina, A; Mikus, G; Müller, F; Schmidt-Gerets, S; Sharma, A; Stopfer, P; Taub, ME; Wiebe, ST | 1 |
| Deutsch, B; Fromm, MF; Gessner, A; Hohl, K; Keller, S; Müller, F; Schmidt-Gerets, S; Schuler-Metz, A; Stopfer, P | 1 |
2 review(s) available for probenecid and verapamil
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
3 trial(s) available for probenecid and verapamil
| Article | Year |
|---|---|
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.
Topics: Adult; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cimetidine; Drug Interactions; Half-Life; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Probenecid; Terfenadine; Uricosuric Agents; Verapamil | 2005 |
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Topics: Area Under Curve; Cimetidine; Drug Interactions; Humans; Male; Probenecid; Rifampin; Verapamil | 2020 |
N
Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Membrane Transport Proteins; Probenecid; Rifampin; Verapamil | 2023 |
85 other study(ies) available for probenecid and verapamil
| Article | Year |
|---|---|
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Caco-2 Cells; Drug Interactions; Humans; Ligands; Models, Theoretical; Paclitaxel; Tritium | 2001 |
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.
Topics: 3T3 Cells; Animals; ATP-Binding Cassette Transporters; Biological Transport; Drug Resistance, Multiple; Folic Acid; Humans; Leucovorin; Methotrexate; Mice; Multidrug Resistance-Associated Proteins; Osmolar Concentration; Polyglutamic Acid; Tritium | 2001 |
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.
Topics: Animals; Antimetabolites, Antineoplastic; Baculoviridae; Carrier Proteins; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Insecta; Liposomes; LLC-PK1 Cells; Methotrexate; Multidrug Resistance-Associated Proteins; Osmosis; Polyglutamic Acid; Receptors, Cell Surface; Swine; Transfection | 2002 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
Topics: Algorithms; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Citrus; Cyclosporine; Food-Drug Interactions; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Plant Extracts; Propionates; Quinolines; Saquinavir; Transfection; Verapamil; Vinblastine | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.
Topics: Apigenin; Binding, Competitive; Cell Line, Tumor; Dimerization; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Etoposide; Humans; Hydroxides; Intracellular Space; Multidrug Resistance-Associated Proteins; Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Leukemia L1210; Methotrexate; Mice; Probenecid; Prostaglandins A; Quinidine; Reserpine; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
Inhibition by basic drugs of digoxin secretion into human bile.
Topics: Bile; Chromatography, High Pressure Liquid; Digoxin; Drug Interactions; Humans; Probenecid; Quinidine; Quinine; Radioimmunoassay; Spironolactone; Verapamil | 1992 |
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump.
Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol; Methotrexate; Probenecid; Prostaglandins A; Rats; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil | 1991 |
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Probenecid; Sulfobromophthalein; Verapamil | 1991 |
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Probenecid; Quinazolines; Time Factors; Verapamil | 1986 |
[Inhibition of adenosine uptake and stimulation of its effect on isolated hearts of warm-blooded animals by coronary active substances].
Topics: Alkaloids; Allopurinol; Animals; Carbon Isotopes; Cocaine; Depression, Chemical; Dipyridamole; Drug Synergism; Ethylenediamines; Guinea Pigs; Heart Rate; In Vitro Techniques; Myocardium; Nitroglycerin; Nucleosides; Ouabain; Papaverine; Prenylamine; Probenecid; Pyridines; Reserpine; Stimulation, Chemical; Theophylline; Triamterene; Vasodilator Agents; Verapamil | 1969 |
Active cell membrane mechanisms involved in the exclusion of Rh 123 allow distinction between normal and tumoral cells.
Topics: Cell Membrane; Cells, Cultured; Drug Resistance, Multiple; Fibroblasts; Flow Cytometry; Humans; Neoplasms; Probenecid; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1994 |
Effect of probenecid, verapamil and progesterone on the concentration-dependent and temperature-sensitive human erythrocyte uptake and export of guanosine 3',5' cyclic monophosphate (cGMP).
Topics: Biological Transport; Carrier Proteins; Cyclic GMP; Erythrocytes; Humans; Kinetics; Probenecid; Progesterone; Temperature; Verapamil | 1995 |
Calcein is excreted from the intestinal mucosal cell membrane by the active transport system.
Topics: Animals; Azides; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Cell Membrane Permeability; Daunorubicin; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; In Vitro Techniques; Intestinal Mucosa; Jejunum; Probenecid; Rats; Renal Agents; Sodium Azide; Sodium Fluoride; Verapamil | 1997 |
Restricted intestinal absorption of some beta-lactam antibiotics by an energy-dependent efflux system in rat intestine.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Energy Metabolism; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; p-Aminohippuric Acid; Probenecid; Rats; Spectrophotometry, Ultraviolet; Uricosuric Agents; Verapamil | 1997 |
Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Erythrocyte Membrane; Humans; Ion Pumps; Probenecid; Progesterone; Theophylline; Verapamil | 1998 |
Estimation of drug resistance by flow cytometry.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Flow Cytometry; Genistein; Leukemia L5178; Mice; Probenecid; Recombinant Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Verapamil | 1998 |
The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Indomethacin; Liver Neoplasms, Experimental; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1999 |
Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Clone Cells; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Knockout; Poly(ADP-ribose) Polymerases; Probenecid; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation; Verapamil | 2000 |
Multidrug resistance P-glycoprotein is not involved in cholesterol esterification.
Topics: Acridines; Anticholesteremic Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholesterol; Cholesterol Esters; DNA-Binding Proteins; Fluoresceins; Fluorescent Dyes; Heptanoic Acids; Humans; Isoquinolines; Kinetics; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Probenecid; Progesterone; Pyrroles; Sterol O-Acyltransferase; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil | 2000 |
Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier.
Topics: Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Caco-2 Cells; Carbamates; Cattle; Cell Line, Transformed; Cells, Cultured; Coculture Techniques; Cyclosporins; Dibenzocycloheptenes; Endothelium, Vascular; Furans; HIV Protease Inhibitors; Humans; Indinavir; LLC-PK1 Cells; Multidrug Resistance-Associated Proteins; Probenecid; Quinolines; Rats; Rats, Wistar; Ritonavir; Sulfonamides; Swine; Verapamil | 2001 |
Interleukin-1beta stimulates cyclic GMP efflux in brain astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Brain; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Interleukin-1; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Probenecid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Verapamil | 2001 |
P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbamazepine; Extracellular Space; Female; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Wistar; Uricosuric Agents; Verapamil | 2001 |
Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants.
Topics: Aniline Compounds; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Brain; Capillaries; Cattle; Cyclohexanones; Endothelium, Vascular; Humans; Injections, Intravenous; Male; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Probenecid; Rhodamine 123; Tissue Distribution; Tumor Cells, Cultured; Verapamil | 2001 |
Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow Transplantation; Calcium Channel Blockers; Carbocyanines; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fluoresceins; Fluorescent Dyes; Genistein; Humans; Idarubicin; Immunophenotyping; Leukemia, Myeloid; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Probenecid; Prognosis; Prospective Studies; Rhodamine 123; Survival Analysis; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2002 |
Budesonide reduces multidrug resistance-associated protein 1 expression in an airway epithelial cell line (Calu-1).
Topics: Blotting, Western; Bronchodilator Agents; Budesonide; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation; Humans; Indomethacin; Lung; Multidrug Resistance-Associated Proteins; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Verapamil; Vincristine | 2002 |
Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters.
Topics: Aminobenzoates; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Brain; Capillaries; Drug Resistance, Multiple; Endothelium, Vascular; Hypoxanthines; Injections, Intraventricular; Male; Mice; Monocarboxylic Acid Transporters; Nootropic Agents; Organic Anion Transporters; Probenecid; Propionates; Purines; Quinolines; Verapamil | 2002 |
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil | 2002 |
Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; DNA, Viral; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genistein; HeLa Cells; HIV; HIV Infections; Humans; Probenecid; Transfection; Verapamil; Virus Replication | 2002 |
Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.
Topics: Adenosine Triphosphate; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Benzoflavones; Biological Transport, Active; Caco-2 Cells; Cell Polarity; Cyclosporine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Enterocytes; Gene Expression; Humans; Models, Biological; Probenecid; Propionates; Quinolines; Verapamil; Vinblastine | 2003 |
Single-cell image analysis to assess ABC-transporter-mediated efflux in highly purified hematopoietic progenitors.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Assay; Flow Cytometry; Fluorescent Dyes; Hematopoietic Stem Cells; Humans; Image Cytometry; Image Processing, Computer-Assisted; Jurkat Cells; Membrane Glycoproteins; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Multiple Myeloma; Probenecid; Reproducibility of Results; Verapamil | 2002 |
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Topics: Acridines; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromycin; Cell Line; Cyclosporine; Cytosol; Gemfibrozil; Isoquinolines; Lysosomes; Macrophages; Mice; Microscopy, Confocal; Monensin; Probenecid; Tetrahydroisoquinolines; Verapamil | 2003 |
UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines.
Topics: Apoptosis; ATP-Binding Cassette Transporters; Cell Death; Cell Line; Cyclosporine; Cytoplasm; Flow Cytometry; Humans; Lymphocytes; Phenotype; Probenecid; Radiation Dosage; Radiation, Ionizing; Rhodamines; Sulfinpyrazone; Tumor Cells, Cultured; Ultraviolet Rays; Verapamil; X-Rays | 2003 |
Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.
Topics: Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Calcium Channels; Cyclosporine; Cyclosporins; Diphenoxylate; Drug Interactions; Humans; Loperamide; Narcotics; Probenecid; Sulfinpyrazone; Verapamil | 2003 |
Probenicid inhibition of fluorescence extrusion after MCB-staining of rat-1 fibroblasts.
Topics: 3T3 Cells; Animals; Fibroblasts; Flow Cytometry; Glutathione Transferase; Histocytochemistry; Mice; Organic Anion Transporters, ATP-Dependent; Probenecid; Pyrazoles; Rats; Uricosuric Agents; Vanadates; Verapamil | 1996 |
Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats.
Topics: Animals; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Levetiracetam; Piracetam; Probenecid; Rats; Rats, Wistar; Verapamil | 2004 |
Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Cell Line, Tumor; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia; Mice; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Predictive Value of Tests; Probenecid; Propionates; Quinolines; Sus scrofa; Up-Regulation; Verapamil; Vinblastine | 2004 |
Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carboxylic Acids; Fumonisins; Humans; Intestinal Absorption; Membrane Potentials; Models, Biological; Mycotoxins; Probenecid; Verapamil | 2005 |
Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.
Topics: Adult; Animals; Calcium Channel Blockers; Cells, Cultured; Gene Expression Regulation; Hepatocytes; Humans; Male; Membrane Transport Proteins; Probenecid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium; Verapamil | 2005 |
Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Drosophila melanogaster; Epithelium; Fluorescent Dyes; Gryllidae; Malpighian Tubules; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Probenecid; Propionates; Quinacrine; Quinolines; Tetraethylammonium; Verapamil | 2005 |
Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Dogs; Humans; Indomethacin; N-Methyl-3,4-methylenedioxyamphetamine; Probenecid; Progesterone; Propionates; Quinolines; Rhodamine 123; Ritonavir; Verapamil | 2006 |
The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2.
Topics: Adenosine Triphosphate; Antioxidants; Biological Transport, Active; Caco-2 Cells; Chromatography, High Pressure Liquid; Disaccharides; Enzyme Inhibitors; Flavonoids; Humans; Intestinal Mucosa; Iodoacetamide; Probenecid; Propionates; Quercetin; Quinolines; Verapamil | 2006 |
Comparison of permeation enhancing strategies for an oral factor Xa inhibitor using the Caco-2 cell monolayer model.
Topics: Algorithms; Antithrombin III; Caco-2 Cells; Cell Membrane Permeability; Chitosan; Drug Synergism; Glycerides; Humans; Molecular Structure; Probenecid; Prodrugs; Quinidine; Serine Proteinase Inhibitors; Spectrophotometry, Ultraviolet; Verapamil | 2006 |
DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Calcium Channel Blockers; Carcinogens; Cell Line, Tumor; Cell Survival; Cyclosporins; DNA Adducts; DNA Damage; Drug Synergism; Female; Humans; Probenecid; Renal Agents; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53; Verapamil | 2007 |
Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.
Topics: Abietanes; Adenosine Triphosphate; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Digoxin; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Probenecid; Propionates; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Temperature; Transfection; Verapamil | 2007 |
Mechanistic study on the intestinal absorption and disposition of baicalein.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport, Active; Caco-2 Cells; Egtazic Acid; Enzyme Inhibitors; Estradiol; Flavanones; Glucuronides; Humans; Intestinal Absorption; Kinetics; Leukotriene C4; Multidrug Resistance-Associated Proteins; Permeability; Probenecid; Propionates; Quinolines; Spectrophotometry, Ultraviolet; Spodoptera; Sulfuric Acid Esters; Tandem Mass Spectrometry; Verapamil | 2007 |
Progesterone inhibits folic acid transport in human trophoblasts.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; ATP-Binding Cassette Transporters; Estradiol; Folic Acid; Humans; Indoles; Indomethacin; Kinetics; p-Aminohippuric Acid; Probenecid; Progesterone; Trophoblasts; Verapamil | 2007 |
Mrp2-related efflux of scutellarin in the intestinal absorption in rats.
Topics: Animals; Antimetabolites; Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport, Active; Buthionine Sulfoximine; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Glucuronates; Intestinal Absorption; Leukotriene C4; Male; Perfusion; Probenecid; Rats; Rats, Sprague-Dawley; Renal Agents; Spectrophotometry, Ultraviolet; Verapamil | 2008 |
Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.
Topics: Animals; Ataxia; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Chromatography, Liquid; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Loratadine; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Probenecid; Tissue Distribution; Verapamil | 2007 |
PET-evaluated transport of [11C]hydroxyurea across the rat blood-brain barrier--lack of influence of cyclosporin and probenecid.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyurea; Male; Mannitol; Positron-Emission Tomography; Probenecid; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil | 2007 |
Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates.
Topics: Adenosine Triphosphate; Animals; Antimony; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Fluoresceins; Humans; Leishmania donovani; Leishmaniasis, Visceral; Multidrug Resistance-Associated Proteins; Ofloxacin; Probenecid; Protozoan Proteins; Rhodamine 123; Verapamil | 2009 |
Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.
Topics: Doxorubicin; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Probenecid; Rhodamine 123; RNA, Messenger; Sodium Azide; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfobromophthalein; Verapamil | 2009 |
Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters.
Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Cephalosporins; Drug Interactions; Liver; Male; Novobiocin; Organic Anion Transporters, Sodium-Independent; Probenecid; Rats; Rats, Wistar; RNA, Messenger; Verapamil | 2010 |
Micellar electrokinetic chromatographic analysis for in vitro accumulation of anthracyclines enhanced by inhibitors of cell membrane transporter-proteins in cancer cells.
Topics: Biological Transport, Active; Cell Line, Tumor; Cellular Structures; Chromatography, Micellar Electrokinetic Capillary; Cyclosporine; Daunorubicin; Humans; Membrane Transport Modulators; Membrane Transport Proteins; Probenecid; Verapamil | 2011 |
Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats.
Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Chromatography, Liquid; Cimetidine; Guanine; Half-Life; Ion Pumps; Kidney; Male; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Probenecid; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Verapamil | 2011 |
Regulation of endocytosis into human brain-microvascular endothelial cells by inhibition of efflux proteins.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cell Death; Cell Survival; Endocytosis; Endothelial Cells; Fluoresceins; Humans; Microvessels; Multidrug Resistance-Associated Proteins; Probenecid; Tight Junctions; Verapamil | 2011 |
Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients.
Topics: Adjuvants, Pharmaceutic; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Epilepsy; Fluoresceins; Gene Expression Regulation; Hippocampus; Humans; In Vitro Techniques; Multidrug Resistance-Associated Proteins; Neocortex; Nerve Tissue Proteins; Neurons; Probenecid; Verapamil | 2011 |
[Transport of limonin in rat intestine in situ and Caco-2 cells in vitro].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Ketoconazole; Limonins; Male; Perfusion; Probenecid; Rats; Verapamil | 2012 |
Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport; Cyclosporine; Female; Fluoresceins; Gene Expression; Male; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Olfactory Mucosa; Olfactory Receptor Neurons; Probenecid; Propionates; Quinolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Verapamil | 2012 |
Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Capsaicin; In Vitro Techniques; Intestinal Absorption; Lower Gastrointestinal Tract; Male; Novobiocin; Permeability; Probenecid; Rats; Rats, Sprague-Dawley; Ruthenium Red; TRPV Cation Channels; Verapamil | 2013 |
A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture.
Topics: Adjuvants, Pharmaceutic; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Cell Culture Techniques; Cell Separation; Cells, Cultured; Coculture Techniques; Cyclosporins; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Indicators and Reagents; Neuroglia; Probenecid; Rats; Rats, Sprague-Dawley; Time Factors; Verapamil | 2013 |
Reporter dyes demonstrate functional expression of multidrug resistance proteins in the marine flatworm Macrostomum lignano: the sponge-derived dye Ageladine A is not a substrate of these transporters.
Topics: Aniline Compounds; Animals; Astrocytes; Biological Transport; Brain; Cells, Cultured; Coloring Agents; Fluoresceins; Fluorescent Dyes; Fura-2; Glutathione; Multidrug Resistance-Associated Proteins; Platyhelminths; Probenecid; Pyrroles; Rats; Rats, Wistar; Rhodamines; Verapamil; Xanthenes | 2013 |
Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acrylic Resins; Algorithms; Animals; Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Biological Availability; Caco-2 Cells; Decanoic Acids; Deoxycholic Acid; Excipients; Folic Acid; Humans; Intestinal Absorption; Male; Pantoprazole; Probenecid; Quinazolines; Rats; Rats, Wistar; Thiophenes; Verapamil | 2013 |
[Study on transport mechanism of baicalin in Scutellariae radix extracts and effect of Angelica dahurica extracts on transport of baicalin by Caco-2 cell monolayer model].
Topics: Angelica; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Coumarins; Drug Interactions; Drugs, Chinese Herbal; Flavonoids; Humans; Intestinal Absorption; Oils, Volatile; Plant Extracts; Plant Roots; Probenecid; Scutellaria baicalensis; Verapamil | 2013 |
Efficiency of transcellular transport and efflux of flavonoids with different glycosidic units from flavonoids of Litsea coreana L. in a MDCK epithelial cell monolayer model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Dogs; Flavonoids; Glycosides; Hydrogen-Ion Concentration; Litsea; Madin Darby Canine Kidney Cells; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Probenecid; Propionates; Quinolines; Sodium-Glucose Transporter 1; Temperature; Verapamil | 2014 |
Intestinal absorptive transport of Genkwanin from Flos genkwa using a single-pass intestinal perfusion rat model.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Dose-Response Relationship, Drug; Duodenum; Flavones; Intestinal Absorption; Intestinal Mucosa; Male; Models, Animal; Pantoprazole; Perfusion; Probenecid; Rats; Rats, Sprague-Dawley; Verapamil | 2014 |
Evaluation of
Topics: Aminosalicylic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cimetidine; Drug Interactions; HEK293 Cells; Humans; Ibuprofen; Liver-Specific Organic Anion Transporter 1; Naproxen; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Probenecid; Proton Pump Inhibitors; Quinidine; Rifampin; Verapamil | 2017 |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method.
Topics: 2,4-Dinitrophenol; Adjuvants, Pharmaceutic; Animals; ATP-Binding Cassette Transporters; Chromatography, High Pressure Liquid; Curcumin; Diarylheptanoids; Emulsions; Enzyme Inhibitors; Female; Intestinal Absorption; Intestine, Small; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion Imaging; Probenecid; Rats, Sprague-Dawley; Reference Values; Reproducibility of Results; Time Factors; Uncoupling Agents; Verapamil | 2017 |