Page last updated: 2024-08-16

probenecid and rifampin

probenecid has been researched along with rifampin in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (25.00)	18.7374
1990's	2 (5.00)	18.2507
2000's	8 (20.00)	29.6817
2010's	15 (37.50)	24.3611
2020's	5 (12.50)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ebner, T; Ishiguro, N; Kishimoto, W; Schaefer, O; Shimizu, H	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Allen, BW; Ellard, GA; Hatfield, AR; Kenwright, S; Levi, AJ; Mitchison, DA	1
Allan, GW; Fallon, RJ; Lees, AW; Smith, J; Tyrrell, WF	1
Christensen, LK; Hansen, JM	1
Brockmeyer, NH; Goos, M; Klimek, K; Mertins, L; Ohnhaus, EE	1
Brockmeyer, NH; Heidemann, H; Ohnhaus, EE	1
Willcox, RR	1
Hansson, H; Juhlin, I	1
Sim, SK	1
Panduro, J	1
Chotiwan, P; Desudchit, P; Dhanamun, B; Nunthapisud, P; Rukjutitum, S; Tattakorn, V	1
Høiby, N; Szaff, M	1
Corbitt, R; Gant, TW; O'Connor, CK; Thorgeirsson, SS; Thorgeirsson, U	1
Choi, CH; Kim, HS; Min, YD	1
Broedl, UC; Hummel, N; Koenen, R; Macha, S; Riedmaier, S; Salsali, A; Schöne, K; Sennewald, R; Woerle, HJ	1
Ariyawansa, J; Curtin, C; Devineni, D; Di Prospero, NA; Mamidi, RN; Murphy, J; Rothenberg, P; Stieltjes, H; Vaccaro, N; Wajs, E; Wang, SS; Weiner, S	1
Coss, CC; Dalton, JT; Jones, A	1
Bai, P; Chen, M; Deng, X; Hu, J; Miao, P; Xu, Y; Yin, H; Yin, J	1
Jung, JA; Parvez, MM; Shin, HJ; Shin, JG	1
Bader, K; Ebner, T; Fromm, MF; Giessmann, T; Hauel, E; Hohl, K; Ishiguro, N; Jambrecina, A; Mikus, G; Müller, F; Schmidt-Gerets, S; Sharma, A; Stopfer, P; Taub, ME; Wiebe, ST	1
Britz, H; Fernandez, É; Hanke, N; Lehr, T; Nock, V; Prasad, B; Stopfer, P; Taub, ME; Wang, T	1
Connell, CA; Dowty, ME; Le, VH; Malhotra, BK; O'Gorman, MT; Tatulych, S; Tripathy, S; Valdez, H; Wang, X; Winton, JA; Wouters, A; Yin, N	1
Aliter, H; El Khateeb, O; Nasser, AS; Stewart, K	1
Deutsch, B; Fromm, MF; Gessner, A; Hohl, K; Keller, S; Müller, F; Schmidt-Gerets, S; Schuler-Metz, A; Stopfer, P	1

Reviews

4 review(s) available for probenecid and rifampin

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions with oral sulphonylurea hypoglycaemic drugs. Drugs, 1977, Volume: 13, Issue:1 Topics: Allopurinol; Analgesics; Anticoagulants; Chloramphenicol; Chlorpropamide; Disulfiram; Drug Interactions; Ethanol; Glyburide; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Monoamine Oxidase Inhibitors; Novobiocin; Phenylbutazone; Phenytoin; Probenecid; Propranolol; Rifampin; Sulfonamides; Sulfonylurea Compounds; Tolbutamide	1977

Trials

7 trial(s) available for probenecid and rifampin

Article	Year
Probenecid and rifampicin serum levels. Lancet (London, England), 1975, Oct-25, Volume: 2, Issue:7939 Topics: Administration, Oral; Adult; Drug Therapy, Combination; Humans; Male; Probenecid; Rifampin; Time Factors; Tuberculosis, Pulmonary	1975
Rifampicin-erythromycin combination for the treatment of gonococcal urethritis in men. The Southeast Asian journal of tropical medicine and public health, 1984, Volume: 15, Issue:3 Topics: Adolescent; Adult; Aged; Ampicillin; Clinical Trials as Topic; Costs and Cost Analysis; Drug Therapy, Combination; Erythromycin; Gonorrhea; Humans; Male; Middle Aged; Neisseria gonorrhoeae; Penicillin Resistance; Probenecid; Rifampin; Thailand; Urethritis	1984
Effect of gemfibrozil, rifampicin, or probenecid on the pharmacokinetics of the SGLT2 inhibitor empagliflozin in healthy volunteers. Clinical therapeutics, 2014, Feb-01, Volume: 36, Issue:2 Topics: Adolescent; Adult; Benzhydryl Compounds; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Gemfibrozil; Glucosides; Humans; Male; Middle Aged; Probenecid; Rifampin; Sodium-Glucose Transporter 2 Inhibitors	2014
Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:2 Topics: Adult; Canagliflozin; Cyclosporine; Drug Interactions; Female; Glucosides; Humans; Male; Probenecid; Rifampin; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes	2015
Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Investigational new drugs, 2016, Volume: 34, Issue:4 Topics: Adult; Anilides; Celecoxib; Cytochrome P-450 Enzyme System; Drug Interactions; Glucuronides; Humans; Itraconazole; Male; Middle Aged; Probenecid; Receptors, Androgen; Rifampin; Rosuvastatin Calcium; Young Adult	2016
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine. Clinical pharmacokinetics, 2020, Volume: 59, Issue:12 Topics: Area Under Curve; Cimetidine; Drug Interactions; Humans; Male; Probenecid; Rifampin; Verapamil	2020
N Clinical pharmacology and therapeutics, 2023, Volume: 113, Issue:5 Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Membrane Transport Proteins; Probenecid; Rifampin; Verapamil	2023

Other Studies

29 other study(ies) available for probenecid and rifampin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Base Sequence; Dipeptidyl-Peptidase IV Inhibitors; DNA Primers; Drug Evaluation, Preclinical; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Linagliptin; LLC-PK1 Cells; Purines; Quinazolines; Swine	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Letter: Probenecid and serum-rifampicin. Lancet (London, England), 1975, Dec-27, Volume: 2, Issue:7948 Topics: Drug Synergism; Humans; Probenecid; Rifampin	1975
Comparative effects of rifampin and/or probenecid on the pharmacokinetics of temazepam and nitrazepam. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:9 Topics: 17-Hydroxycorticosteroids; Adult; Antipyrine; Endoplasmic Reticulum; Humans; Hydrocortisone; Nitrazepam; Probenecid; Rifampin; Temazepam; Time Factors	1990
Enzyme induction of renal transport mechanism by rifampicin in man? Pharmacology & therapeutics, 1987, Volume: 33, Issue:1 Topics: Antipyrine; Biological Transport; Edetic Acid; Enzyme Induction; Glomerular Filtration Rate; Humans; Iodohippuric Acid; Kidney; Kidney Tubules; Probenecid; Rifampin	1987
Recent developments in the treatment of gonorrhoea. The British journal of venereal diseases, 1970, Volume: 46, Issue:2 Topics: Demeclocycline; Drug Synergism; Gonorrhea; Humans; Male; Penicillin G Procaine; Penicillin Resistance; Probenecid; Rifampin; Rolitetracycline	1970
[Therapy and therapy-control in uncomplicated gonorrhea]. Lakartidningen, 1971, Sep-15, Volume: 68, Issue:38 Topics: Doxycycline; Erythromycin; Female; Gonorrhea; Humans; Leucomycins; Lincomycin; Male; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Penicillins; Probenecid; Rifampin; Tetracycline	1971
Chemotherapy of gonorrhea: a review of current status. Canadian Medical Association journal, 1972, Nov-18, Volume: 107, Issue:10 Topics: Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Erythromycin; Gonorrhea; Humans; Kanamycin; Penicillins; Probenecid; Rifampin; Sulfonamides; Trimethoprim	1972
Treatment of acute gonorrhoea with a single oral dose of rifampicin. The British journal of venereal diseases, 1971, Volume: 47, Issue:6 Topics: Acute Disease; Administration, Oral; Female; Gonorrhea; Humans; Male; Penicillins; Probenecid; Rifampin	1971
Antibiotic treatment of Staphylococcus aureus infection in cystic fibrosis. Acta paediatrica Scandinavica, 1982, Volume: 71, Issue:5 Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Child, Preschool; Cystic Fibrosis; Dicloxacillin; Female; Fusidic Acid; Humans; Infant; Male; Oxacillin; Probenecid; Pseudomonas Infections; Rifampin; Staphylococcal Infections	1982
In vivo induction of liver P-glycoprotein expression by xenobiotics in monkeys. Toxicology and applied pharmacology, 1995, Volume: 133, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Weight; Densitometry; Diethylstilbestrol; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Erythromycin; Female; Gene Expression Regulation; Liver; Macaca mulatta; Male; Organ Size; Probenecid; Rifampin; RNA, Messenger; Tamoxifen	1995
Double-edged sword of chemosensitizer: increase of multidrug resistance protein (MRP) in leukemic cells by an MRP inhibitor probenecid. Biochemical and biophysical research communications, 2001, Apr-27, Volume: 283, Issue:1 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blotting, Western; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Erythromycin; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Multidrug Resistance-Associated Proteins; Ofloxacin; Probenecid; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Tumor Cells, Cultured; Uricosuric Agents; Vincristine	2001
ABC transporters affect the elimination and toxicity of CdTe quantum dots in liver and kidney cells. Toxicology and applied pharmacology, 2016, 07-15, Volume: 303 Topics: Animals; ATP-Binding Cassette Transporters; Cadmium Compounds; Cell Line; Cell Survival; Cyclosporine; Dogs; Hep G2 Cells; Humans; Kidney; Liver; Madin Darby Canine Kidney Cells; Oligopeptides; Probenecid; Propionates; Quantum Dots; Quinolines; Rifampin; RNA, Messenger; Tellurium	2016
Evaluation of Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5 Topics: Aminosalicylic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cimetidine; Drug Interactions; HEK293 Cells; Humans; Ibuprofen; Liver-Specific Organic Anion Transporter 1; Naproxen; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Probenecid; Proton Pump Inhibitors; Quinidine; Rifampin; Verapamil	2017
Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions. Pharmaceutical research, 2020, Nov-25, Volume: 37, Issue:12 Topics: Administration, Intravenous; Administration, Oral; Adult; Biotransformation; Computer Simulation; Drug Elimination Routes; Drug Interactions; Female; Furosemide; Humans; Male; Models, Biological; Organic Anion Transporters; Probenecid; Rifampin	2020
Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals. European journal of drug metabolism and pharmacokinetics, 2022, Volume: 47, Issue:3 Topics: Adult; Area Under Curve; Clinical Trials, Phase I as Topic; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Fluconazole; Fluvoxamine; Humans; Probenecid; Pyrimidines; Rifampin; Sulfonamides	2022
Successful drainage of periaortic graft abscess and transcatheter aortic valve replacement in the same setting-A hybrid approach. Journal of cardiac surgery, 2022, Volume: 37, Issue:11 Topics: Abscess; Aged, 80 and over; Anti-Bacterial Agents; Aortic Valve; Aortic Valve Stenosis; Cefadroxil; Cefazolin; Drainage; Heart Valve Prosthesis; Humans; Male; Methicillin; Probenecid; Rifampin; Transcatheter Aortic Valve Replacement	2022