probenecid has been researched along with quinine in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (40.48) | 18.7374 |
| 1990's | 4 (9.52) | 18.2507 |
| 2000's | 9 (21.43) | 29.6817 |
| 2010's | 11 (26.19) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Akhoundova, A; Arndt, P; Bamberg, E; Budiman, T; Gorboulev, V; Koepsell, H; Koppatz, S; Nagel, G; Popp, C; Ulzheimer-Teuber, I; Volk, C | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Masseno, V; Muriithi, S; Nzila, A | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Mudge, GH; Silva, P; Stibitz, GR | 1 |
| Cacini, W; Quebbemann, AJ | 1 |
| Barzaghi, D; Salvaterra, M; Setnikar, I; Veronese, M | 1 |
| Hedman, A | 1 |
| Cacini, W; Wernke, MJ | 1 |
| Bartlett, JG; Hendrix, CW; Kornhauser, DM; Lietman, PS; Nerhood, LJ; Petty, BG; Woods, AS | 1 |
| Cacini, W; Myre, SA | 1 |
| Hahn, I; Krieglstein, G; Krieglstein, J; Tschentscher, K | 1 |
| Fujimoto, JM; Hakim, R; Watrous, WM | 1 |
| Sladek, NE | 1 |
| Anders, MW; Quebbemann, AJ | 1 |
| Quebbemann, AJ | 1 |
| Holmes, J; Sapeika, N; Zwarenstein, H | 1 |
| Quebbemann, AJ; Rennick, BR | 1 |
| Santos-Martinez, J; Selkurt, EE; Wathen, RL | 1 |
| Arendshorst, WJ; Selkurt, EE | 1 |
| Berndt, WO; Grote, D | 1 |
| Cacini, W; Grund, VR; Keller, MB | 1 |
| Roch-Ramel, F; Schäli, C | 1 |
| Pritchard, JB; Sweet, DH | 1 |
| Hu, Y; Keep, RF; Ocheltree, SM; Shen, H; Smith, DE | 1 |
| Kanjanamekanant, K; Luckprom, P; Pavasant, P | 1 |
| Kobashi, M; Masamoto, M; Mitoh, Y; Shigemura, N; Yoshida, R | 1 |
2 review(s) available for probenecid and quinine
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for probenecid and quinine
| Article | Year |
|---|---|
Probenecid and zidovudine metabolism.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; AIDS-Related Complex; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Patient Compliance; Probenecid; Quinine; Zidovudine | 1989 |
39 other study(ies) available for probenecid and quinine
| Article | Year |
|---|---|
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.
Topics: Animals; Anions; Carrier Proteins; Cations; Cell Line; Cell Membrane; Choline; Cloning, Molecular; Female; Guanidine; Histamine; Humans; In Vitro Techniques; Kidney; Kinetics; Membrane Potentials; Membrane Proteins; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Patch-Clamp Techniques; Quinine; Rats; Recombinant Proteins; Tetraethylammonium; Transfection; Xenopus laevis | 2001 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Renal excretion by non-ionic diffusion: the nature of the disequilibrium.
Topics: Animals; Body Fluids; Diffusion; Dimethadione; Dogs; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Inulin; Kidney; Kidney Tubules; Kinetics; Lipids; Mathematics; Models, Biological; Nephrons; Postural Balance; Probenecid; Quinine; Salicylates; Solubility; Sulfanilamides; Triazines; Urine | 1975 |
The metabolism and active excretion of the hypoxanthine by the renal tubules in the chicken.
Topics: Allopurinol; Animals; Chickens; Female; Hypoxanthines; Kidney; Kidney Tubules; Oxypurinol; p-Aminohippuric Acid; Probenecid; Quinine | 1978 |
Effects of different drugs on the urinary excretion of nifurpipone (NP) and of nitrofurantoin (NTF) in the rat.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydrochlorothiazide; Male; Nitrofurans; Nitrofurantoin; Phenobarbital; Proadifen; Probenecid; Quinine; Rats; Time Factors | 1975 |
Inhibition by basic drugs of digoxin secretion into human bile.
Topics: Bile; Chromatography, High Pressure Liquid; Digoxin; Drug Interactions; Humans; Probenecid; Quinidine; Quinine; Radioimmunoassay; Spironolactone; Verapamil | 1992 |
Concentrative uptake of digoxin by slices of chicken renal cortex.
Topics: Animals; Chickens; Digitoxin; Digoxigenin; Digoxin; Female; Hexoses; Kidney Cortex; Kinetics; Ouabain; Potassium; Probenecid; Quinine; Sodium Cyanide; Spironolactone | 1990 |
Uptake of trimethoprim by renal cortex.
Topics: Animals; Biological Transport, Active; Cold Temperature; Dinitrophenols; Energy Metabolism; Female; Kidney Cortex; Kinetics; Male; Nitrogen; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Trimethoprim; Tritium | 1985 |
Distribution of chlorpromazine in a simplified blood influenced by various drugs.
Topics: Acetazolamide; Animals; Antidepressive Agents; Benzoates; Binding Sites; Binding, Competitive; Cattle; Chlorothiazide; Chlorpromazine; Coumarins; Deoxycholic Acid; Erythrocytes; Fatty Acids; Indomethacin; Phenylbutazone; Phenytoin; Probenecid; Protein Binding; Quinine; Salicylates; Serum Albumin, Bovine; Solubility; Sulfonamides; Suramin; Tetracycline; Thiopental | 1973 |
The renal tubular transport and metabolism of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the chicken.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Chickens; Female; Hydrazines; Hydroxyindoleacetic Acid; Kidney Tubules; Piperidines; Probenecid; Quinine; Saphenous Vein; Serotonin; Tritium; Urine | 1970 |
Therapeutic efficacy of cyclophosphamide as a function of inhibition of its metabolism.
Topics: Alkylation; Animals; Azaguanine; Binding, Competitive; Carcinoma 256, Walker; Cyclophosphamide; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Male; Meperidine; Mercaptopurine; Metyrapone; Microsomes, Liver; Morphine; Phenacetin; Proadifen; Probenecid; Quinine; Rats | 1972 |
Renal tubular conjugation and excretion of phenol and p-nitrophenol in the chicken: differing mechanisms of renal transfer.
Topics: Aminohippuric Acids; Animals; Carbon Isotopes; Catechols; Chickens; Female; Glucuronates; Kidney Tubules; Morphine; Nitrophenols; Phenols; Probenecid; Quinine; Sulfates | 1973 |
Renal synthesis of uric acid.
Topics: Allopurinol; Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Chickens; Chromatography, Thin Layer; Diuresis; Female; Glomerular Filtration Rate; Kidney; Kidney Tubules; Models, Biological; Oxidation-Reduction; Probenecid; Quinine; Uric Acid; Xanthines | 1973 |
Inhibitory effect of some quinoline, phthalazine, and coumarin derivatives on glucose-6-phosphate dehydrogenase in vitro.
Topics: Binding, Competitive; Chloroquine; Coumarins; Glucosephosphate Dehydrogenase; Heterocyclic Compounds; Hydralazine; Isoniazid; Novobiocin; Phenazines; Phenelzine; Phenylhydrazines; Probenecid; Pyridines; Quinacrine; Quinidine; Quinine; Quinolines; Sulfanilamides; Warfarin; Yeasts | 1973 |
Effects of structural modifications of catecholamines on renal tubular transport in the chicken.
Topics: Aminohippuric Acids; Animals; Biological Transport; Carbon Isotopes; Catecholamines; Chickens; Dopamine; Epinephrine; Ethylamines; Isoproterenol; Kidney Tubules; Norepinephrine; Octopamine; Phenethylamines; Probenecid; Quinine; Tetraethylammonium Compounds; Tritium; Tyramine | 1969 |
Creatinine excretion in the squirrel monkey.
Topics: Absorption; Aminohippuric Acids; Animals; Biological Transport; Creatinine; Depression, Chemical; Edetic Acid; Female; Haplorhini; Kidney Tubules; Piperidines; Probenecid; Quinine | 1968 |
Renal tubular mechanisms for creatinine secretion in the guinea pig.
Topics: Aminohippuric Acids; Animals; Biological Transport; Creatinine; Guinea Pigs; Kidney Function Tests; Kidney Tubules; Probenecid; Quinine | 1970 |
The accumulation of C14-dinitrophenol by slices of rabbit kidney cortex.
Topics: Acetates; Aminohippuric Acids; Animals; Azides; Caprylates; Carbon Isotopes; Chloromercuribenzoates; Choline; Chromatography, Paper; Citrates; Cresols; Cyanides; Dinitrophenols; Fatty Acids; Glucose; Glutarates; In Vitro Techniques; Kidney; Lactates; Probenecid; Pyruvates; Quinine; Rabbits; Succinates; Tetraethylammonium Compounds | 1968 |
Accumulation of cimetidine by kidney cortex slices.
Topics: Animals; Cimetidine; Dogs; Energy Metabolism; Guanidines; In Vitro Techniques; Kidney Cortex; Male; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Sodium Cyanide; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1982 |
Renal handling of [14C]allantoin in the rabbit.
Topics: Allantoin; Animals; Drug Interactions; Female; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Kidney Cortex; Male; Probenecid; Quinine; Rabbits; Salicylates | 1980 |
rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Membrane; Cells, Cultured; Cyclosporine; Dogs; Female; Gene Library; In Vitro Techniques; Kinetics; Membrane Potentials; Niacinamide; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 2; Probenecid; Quinacrine; Quinine; Rats; Recombinant Proteins; Tetraethylammonium; Xenopus laevis | 1999 |
Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice.
Topics: Animals; Anti-Bacterial Agents; Biotransformation; Blood-Brain Barrier; Brain; Cefadroxil; Choroid Plexus; Drug Stability; Female; Injections, Intravenous; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Probenecid; Quinine; Symporters | 2007 |
New bitter blocker discovered, study finds.
Topics: Benzoates; Benzyl Alcohols; Glucosides; Humans; Probenecid; Quinine; Receptors, G-Protein-Coupled; Taste | 2011 |
P2X7 receptor-Pannexin1 interaction mediates stress-induced interleukin-1 beta expression in human periodontal ligament cells.
Topics: Adenosine Triphosphate; Biomechanical Phenomena; Carbenoxolone; Cell Culture Techniques; Cells, Cultured; Connexin 43; Connexins; Humans; Interleukin-1beta; Meclofenamic Acid; Nerve Tissue Proteins; Periodontal Ligament; Probenecid; Quinine; Receptors, Purinergic P2X7; RNA, Small Interfering; Spermine; Stress, Mechanical | 2014 |
Effects of bitter receptor antagonists on behavioral lick responses of mice.
Topics: Amino Acids; Animals; Behavior, Animal; gamma-Aminobutyric Acid; Mice; Probenecid; Quinine; Receptors, G-Protein-Coupled; Taste | 2020 |