probenecid has been researched along with procainamide in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.93) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Akhoundova, A; Arndt, P; Bamberg, E; Budiman, T; Gorboulev, V; Koepsell, H; Koppatz, S; Nagel, G; Popp, C; Ulzheimer-Teuber, I; Volk, C | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Boyd, RA; Chang, D; Chin, SK; Giacomini, KM; Lam, YW | 1 |
| Kunnemann, ME; McKinney, TD | 1 |
| Gigon, PL; Guarino, AM | 1 |
| Lanman, RC; Muranishi, S; Schanker, LS | 1 |
| Hwang, SW; Schanker, LS | 1 |
| Klaassen, CD | 1 |
| Kupferberg, HJ; Schankl, LS | 1 |
| McKinney, TD; Speeg, KV | 1 |
| Fukushima, S; Inotsume, N; Kamizono, A; Nakano, M; Okamoto, Y | 1 |
| Lai, PC; Walters, JD | 1 |
2 review(s) available for probenecid and procainamide
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for probenecid and procainamide
| Article | Year |
|---|---|
Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide.
Topics: Adult; Cations; Drug Interactions; Humans; Injections, Intravenous; Kidney Tubules, Proximal; Male; Probenecid; Procainamide | 1991 |
24 other study(ies) available for probenecid and procainamide
| Article | Year |
|---|---|
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.
Topics: Animals; Anions; Carrier Proteins; Cations; Cell Line; Cell Membrane; Choline; Cloning, Molecular; Female; Guanidine; Histamine; Humans; In Vitro Techniques; Kidney; Kinetics; Membrane Potentials; Membrane Proteins; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Patch-Clamp Techniques; Quinine; Rats; Recombinant Proteins; Tetraethylammonium; Transfection; Xenopus laevis | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Cimetidine transport in rabbit renal cortical brush-border membrane vesicles.
Topics: Animals; Biological Transport, Active; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cimetidine; Female; Hydrogen-Ion Concentration; Kidney Cortex; Microvilli; Osmolar Concentration; Probenecid; Procainamide; Quinidine; Rabbits; Tetraethylammonium Compounds; Valinomycin | 1987 |
Uptake of probenecid by rat liver slices.
Topics: Animals; Biological Transport, Active; Carbon Isotopes; Chlorothiazide; Chromatography, Gas; Cyanides; Filtration; Glucuronates; Imides; In Vitro Techniques; Iodoacetates; Iopanoic Acid; Liver; Male; Maleates; NAD; Phlorhizin; Probenecid; Procainamide; Protein Binding; Rats; Sodium; Sulfobromophthalein; Triazines; Ultracentrifugation | 1970 |
Hepatic uptake and biliary excretion of tetracycline in the rat.
Topics: Aminohippuric Acids; Animals; Bile; Biological Transport, Active; Chlortetracycline; Depression, Chemical; Doxycycline; Kinetics; Liver; Male; Methacycline; Oxytetracycline; Probenecid; Procainamide; Rats; Tetracycline; Time Factors; Tritium | 1973 |
Hepatic uptake and biliary excretion of N-acetyl procaine amide ethobromide in the rat.
Topics: Animals; Benzilates; Bile; Biological Transport, Active; Blood Proteins; Chloromercuribenzoates; Depression, Chemical; Diffusion; In Vitro Techniques; Iodoacetates; Liver; Liver Function Tests; Male; Probenecid; Procainamide; Quaternary Ammonium Compounds; Rats; Sulfobromophthalein | 1973 |
Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats.
Topics: Animals; Bile; Bile Acids and Salts; Bilirubin; Chlorothiazide; Coloring Agents; Indocyanine Green; Male; Ouabain; Phenobarbital; Phenols; Probenecid; Procainamide; Rats; Succinates; Sulfathiazoles; Sulfobromophthalein | 1970 |
Biliary secretion of ouabain-3H and its uptake by liver slices in the rat.
Topics: Aminohippuric Acids; Animals; Bile; Biological Transport, Active; Chromatography, Thin Layer; Digitoxin; Digoxin; Glycosides; Injections, Intravenous; Liver; Liver Extracts; Male; Organ Size; Ouabain; Parasympatholytics; Plants, Medicinal; Probenecid; Procainamide; Rats; Tritium | 1968 |
Cimetidine and procainamide secretion by proximal tubules in vitro.
Topics: Absorption; Acecainide; Animals; Carbon Dioxide; Chromatography, High Pressure Liquid; Cimetidine; Guanidines; Hypothermia; Kidney Tubules, Proximal; Kinetics; Ouabain; Probenecid; Procainamide; Quinidine; Rabbits | 1982 |
Inhibitory effects of procainamide and probenecid on renal excretion of sultopride enantiomers in rats.
Topics: Amisulpride; Animals; Drug Interactions; Injections, Intravenous; Kidney; Male; Probenecid; Procainamide; Psychotropic Drugs; Rats; Rats, Wistar; Stereoisomerism; Sulpiride | 1993 |
Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Azithromycin; Biological Transport; Carnitine; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Gingiva; Humans; Kinetics; Probenecid; Procainamide; Pyrilamine; Quinidine; Time Factors | 2013 |