probenecid has been researched along with penicillin g in 151 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (67.55) | 18.7374 |
| 1990's | 16 (10.60) | 18.2507 |
| 2000's | 17 (11.26) | 29.6817 |
| 2010's | 15 (9.93) | 24.3611 |
| 2020's | 1 (0.66) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, BS; Lu, R; Schuster, VL | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Jung, KY; Kim, DK; Narikawa, S; Sekine, T; Takeda, M; Tojo, A; Yoo, BS | 1 |
| Endou, H; Kusuhara, H; Nagata, Y; Sugiyama, Y | 1 |
| Babu, E; Cha, SH; Endou, H; Enomoto, A; Kobayashi, Y; Narikawa, S; Sakthisekaran, D; Sekine, T; Takeda, M; Tojo, A | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Khamdang, S; Kimura, H; Narikawa, S; Sekine, T; Takeda, M | 1 |
| Deguchi, T; Hosoya, K; Kang, YS; Mori, S; Ohtsuki, S; Takanaga, H; Terasaki, T | 1 |
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bommareddy, A; Gionfriddo, MR; Heindel, GA; Mukhija, P; Vanwert, AL; Witkowski, S; Wolman, AT | 1 |
| Fent, K; Popovic, M; Smital, T; Zaja, R | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Allen, MA; Borzelleca, JF; Wrenn, JM | 1 |
| Fogarty, P; Newnham, WA; Walker, WR | 1 |
| Biddle, JW; Jaffe, HW; Johnson, RE; Kaufman, RE; Reynolds, GH; Thornsberry, C; Wiesner, PJ | 1 |
| Neubert, U; Petzoldt, D | 1 |
| Al-Egaily, SS; Dunlop, EM; Houang, ET | 1 |
| Celozzi, E; Miller, AK; Pelak, BA | 1 |
| Chiminello, FJ; Doku, HC; Maloney, PL; Silbermann, M | 1 |
| Arias, IM; Fleischner, G; Kamisaka, K; Kirsch, R | 1 |
| Calne, DB; Claveria, LE; Teychenne, PF; Walters, IN | 1 |
| Barza, M; Bergeron, MG; Brusch, J; Kemmotsu, O; Weinstein, L | 1 |
| Möhlenbeck, F; Simon, C; Traub, U | 1 |
| Gleich, LL; Kimmelman, CP; Linstrom, CJ | 1 |
| Abath Filho, L; Belli, L; Lassus, A; Santos Júnior, MF | 1 |
| Rybak, LP; Scott, V; Weberg, A; Whitworth, C | 2 |
| Cao, CX; Neu, HC; Silverstein, SC; Steinberg, TH | 1 |
| Takeda, K; Tamai, I; Terasaki, T; Tsuji, A | 1 |
| Rybak, LP; Scott, V; Whitworth, C | 1 |
| Budiev, AIu; Navolotskaia, TI; Podgornyĭ, AE; Rotanov, SV | 1 |
| Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y; Suzuki, H | 1 |
| Arroyave, R; García, J; Maldonado, A; Villalobos, D | 1 |
| Rybak, LP; Whitworth, C | 1 |
| Calderón, E; Conde, CJ; de la Cruz, R; Hirata, C; Narcio, L | 1 |
| Lee, CT; Lim, KB; Sng, EH; Tan, T; Thirumoorthy, T | 2 |
| Haaxma-Reiche, H; Kraai, EJ; Snijder, JA; van der Valk, PG; van Voorst Vader, PC | 1 |
| Deighton Fimls, R; Mohanty, KC; Strachan, RG | 1 |
| Hermans, J; Mattie, H; Overbosch, D; Van Gulpen, C | 1 |
| Johnson, K; Roberts, P; Rompalo, AM; Stamm, WE | 1 |
| Deighton, R; Mohanty, KC; Strachan, RG | 1 |
| Nakashima, E; Takanosu, K; Tamai, I; Terasaki, T; Tsuji, A | 1 |
| Brokerhof, AW; Mattie, H; Tjaden, UR; van der Kaay, M; van Gulpen, C | 1 |
| Abashina, NIu; Arzamastsev, AP; Bednova, VN; Nazarova, AIu | 1 |
| Eriksson, G | 2 |
| Niordson, AM; Ullman, S | 1 |
| Darrell, JH; Spiers, AS; Tattersall, MH | 1 |
| Eriksson, G; Wallmark, G | 1 |
| Malmborg, AS; Molin, L; Nyström, B | 1 |
| Morris, JF; Okies, JE | 1 |
| Hallinger, L | 1 |
| Kohen, DP | 1 |
| Thin, RN | 2 |
| Barrett-Connor, E | 1 |
| Smithurst, BA | 1 |
| Brown, ST; McMinn, T | 1 |
| Mitchell, RW; Robson, HG | 1 |
| Holmes, KK; Kass, EH; Sparling, PF; Wiesner, PJ | 1 |
| Kaplan, K; Reisberg, BE; Weinstein, L | 1 |
| Bartel, J | 1 |
| Lomholt, G; Masawe, AE; Nsibambi, J | 1 |
| Olsen, GA | 1 |
| Sulman, FG; Ziv, G | 1 |
| Davidson, D; Gibaldi, M; Plaut, ME; Schwartz, MA | 1 |
| Afable, VL; Halverson, CW; Holmes, KK; Johnson, DW; Kvale, PA; Stewart, SD | 1 |
| Gray, RC; Nicol, CS; Phillips, I | 1 |
| Nicol, CS | 1 |
| Kind, AC; Kirby, WM | 1 |
| Hansson, H; Juhlin, I | 1 |
| Bro-Jorgensen, A; Jensen, T | 1 |
| Tune, BM | 1 |
| Gibaldi, M; Perrier, D | 1 |
| Gibaldi, M; Jusko, WJ | 1 |
| Graber, CD; Jervey, LP; Ostrander, WE; Salley, LH; Weaver, RE | 1 |
| Beaty, HN; Petersdorf, RG; Turck, M | 1 |
| Brodie, JL; Johnson, LD; Kirby, WM; Tuano, SB | 1 |
| Dixon, RL; Owens, ES; Rall, DP | 1 |
| Gjessing, HC; Gundersen, T; Odegaard, K | 1 |
| Meade, RH | 1 |
| Jordan, MC; Kirby, WM; Standiford, HC | 1 |
| Goldman, EE; McLain, JH; Smith, JL | 1 |
| Lomholt, G; Olsen, GA | 2 |
| Carroll, KF; Long, FL; Smith, RB | 1 |
| Fishman, RA | 1 |
| Lomholt, G | 1 |
| Wren, BG | 1 |
| Lerner, PI; Smith, H; Weinstein, L | 1 |
| Holterman, M; Jonsson, A; Sandström, E; Wallmark, G | 1 |
| Wilkowske, CJ; Wright, AJ | 1 |
| Backhaus, A; Jungmann, D; Koeppen, M; Schepers, BF; Wehrspann, P | 1 |
| Alper, B; Gelfand, M; Kaiser, AB; Schlech, WF | 1 |
| Haidl, S; Hoffstedt, B; Walder, M | 1 |
| Catlin, BW | 1 |
| Arroyave, R; Dillon, JR; Fich, F; García, J; Maldonado, A; Salvo, A; Vicent, P; Villalobos, D | 1 |
| Goh, BT; Lim, KS; Samarasinghe, L; Singh, V; Smith, GW | 1 |
| Evans, AJ; Morrison, GD; Price, DJ | 1 |
| Hunter, FE; Irwin, C; O'Brien, JK; Stein, RL; Townsend-Parchman, JK | 1 |
| Browning, MC; Tune, BM | 1 |
| Van der Linden, AJ | 1 |
| Baltch, AL; Belin, MW; Hay, PB | 1 |
| Evans, KE; Linton, CL; Stokes, JE | 1 |
| Germer, S; Shann, F | 1 |
| Gärtner, R; Heise, H; Nerius, I; Neumann, E; Pallmar, D; Plötz, WD; Rosenkranz, H; Wetzel, I | 1 |
| Bergholz, H; Damm, KH; Erttmann, RR | 1 |
| Tight, RR; White, AC | 1 |
| Polnikorn, N; Vejjajiva, A; Vejjajiva, S; Vorachit, M; Witoonpanich, R | 1 |
| Freiesleben, H; Petzoldt, D; Sturm, V | 1 |
| Bulat, M; Klarica, M; Strikić, N; Vladić, A | 1 |
| Frey, HH; Merck, CC; Nielsen, P; Rasmussen, F; Schadewinkel-Scherkl, AM | 1 |
| Nye, FJ | 1 |
| Biber, J; Broer, S; Busch, AE; Lang, F; Murer, H; Schuster, A; Wagner, CA; Waldegger, S; Zempel, G | 1 |
| Ooie, T; Sugiyama, Y; Suzuki, H; Terasaki, T | 1 |
| Kinlough-Rathbone, RL; Packham, MA; Perry, DW; Rand, ML; Ruben, DH | 1 |
| Galla, HJ; Hakvoort, A; Haselbach, M | 1 |
| Bulat, M; Jurcić, D; Klarica, M; Strikić, N; Vladić, A; Zmajević, M | 1 |
| MARMELL, M; PRIGOT, A | 1 |
| JANDL, JH | 1 |
| KUNIN, CM | 2 |
| PLATTNER, HC; SCHERER, J | 1 |
| Hartmann, M | 1 |
| Endou, H; Hirono, S; Kusuhara, H; Nagata, Y; Sugiyama, Y | 1 |
| Schnabolk, GW; Sweet, DH; Youngblood, GL | 1 |
| Adachi, M; Adachi, Y; Hu, Z; Kamiyama, E; Kondo, T; Kusuhara, H; Maeda, K; Nakazawa, H; Okano, T; Schuetz, JD; Shiroyanagi, Y; Sugiyama, D; Sugiyama, Y; Yamada, A | 1 |
| Baker, PN; Bowring, J; Mahto, M; Mandal, D | 1 |
| Day, C; Suh, JD; Vorasubin, N; Wu, AW | 1 |
| Agarwal, S; Elmquist, WF; Li, L | 1 |
| Asahi, S; Ebihara, T; Itoh, T; Jinno, F; Kadotani, R; Kondo, T; Moriya, Y; Tagawa, Y; Takeuchi, T | 1 |
| Fujita, T; Horita, S; Ikeda, Y; Kondo, T; Kumagai, Y; Kusuhara, H; Maeda, K; Nakayama, H; Sugiyama, Y; Tanabe, K; Tian, Y | 1 |
| Covelli, V; Khanapara, DB; Naut, ER | 1 |
| Imamura, Y; Kato, K; Kumagai, Y; Kusuhara, H; Maeda, K; Sano, Y; Sugiyama, Y; Tsuruya, Y | 1 |
| Feng, B; Litchfield, J; Mathialagan, S; Piotrowski, MA; Tess, DA; Varma, MV | 1 |
| Dunaway, SB; Marra, CM; Maxwell, CL; Sahi, SK; Tantalo, LC | 1 |
2 review(s) available for probenecid and penicillin g
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Invasive sinonasal actinomycosis: case report and literature review.
Topics: Actinomycosis; Adjuvants, Pharmaceutic; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Diagnosis, Differential; Drug Therapy, Combination; Humans; Male; Middle Aged; Paranasal Sinus Diseases; Penicillin G; Positron-Emission Tomography; Probenecid; Tomography, X-Ray Computed | 2013 |
12 trial(s) available for probenecid and penicillin g
| Article | Year |
|---|---|
[One time therapy of gonorrhea. Clinical experimental studies with penicillin/probenecid and spectinomycin].
Topics: Clinical Trials as Topic; Delayed-Action Preparations; Drug Therapy, Combination; Gonorrhea; Humans; Male; Penicillin G; Penicillins; Probenecid; Spectinomycin | 1976 |
Otosyphilis: a diagnostic and therapeutic dilemma.
Topics: Adult; Aged; Amoxicillin; Cardiolipins; Cerebrospinal Fluid; Cholesterol; Clinical Protocols; Cochlear Diseases; Decision Trees; Drug Therapy, Combination; Female; Fluorescent Treponemal Antibody-Absorption Test; Hearing Tests; Humans; Male; Middle Aged; New York City; Penicillin G; Phosphatidylcholines; Prednisone; Probenecid; Syphilis; Vestibular Diseases | 1992 |
Comparison of fleroxacin and penicillin G plus probenecid in the treatment of acute uncomplicated gonococcal infections.
Topics: Acute Disease; Adolescent; Adult; Drug Therapy, Combination; Fleroxacin; Gonorrhea; Humans; Male; Middle Aged; Penicillin G; Probenecid; Treatment Outcome; Urethral Diseases | 1992 |
Treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae in Mexico City.
Topics: Adolescent; Adult; Cefotaxime; Drug Resistance, Microbial; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Probenecid; Random Allocation; Spectinomycin; Urethritis | 1987 |
A comparative study of aztreonam and procaine penicillin/probenecid in the treatment of uncomplicated gonorrhoea.
Topics: Aztreonam; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Penicillin G; Penicillin G Procaine; Penicillinase; Probenecid; Random Allocation | 1988 |
Empirical therapy for the management of acute proctitis in homosexual men.
Topics: Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Drug Therapy, Combination; Gonorrhea; Homosexuality; Humans; Male; Middle Aged; Penicillin G; Penicillin G Procaine; Probenecid; Proctitis; Proctocolitis; Random Allocation | 1988 |
Single intramuscular injection of aztreonam in the treatment of uncomplicated gonorrhoea in women.
Topics: Aztreonam; Drug Evaluation; Female; Gonorrhea; Humans; Injections, Intramuscular; Microbial Sensitivity Tests; Penicillin G; Probenecid | 1987 |
Modification of penicillin distribution and elimination by probenecid.
Topics: Adult; Clinical Trials as Topic; Depression, Chemical; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Penicillin G; Probenecid | 1970 |
Comparative blood levels of hetacillin, ampicillin and penicillin G.
Topics: Ampicillin; Clinical Trials as Topic; Humans; Penicillin G; Penicillins; Probenecid | 1966 |
[Treatment of gonorrhea with spectinomycin and penicillin].
Topics: Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gonorrhea; Humans; Injections, Intramuscular; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae; Penicillin G; Probenecid; Spectinomycin | 1984 |
[Treatment of gonorrhea in Santiago de Chile].
Topics: Acute Disease; Anti-Bacterial Agents; Chile; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Probenecid; Tetracycline | 1984 |
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.
Topics: Adenine; Adult; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; p-Aminohippuric Acid; Penicillin G; Probenecid; Young Adult | 2014 |
137 other study(ies) available for probenecid and penicillin g
| Article | Year |
|---|---|
Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; DNA, Complementary; HeLa Cells; Humans; Kidney; Molecular Sequence Data; p-Aminohippuric Acid; Protein Kinase C; Rats; Substrate Specificity; Tissue Distribution | 1999 |
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Characterization of ochratoxin A transport by human organic anion transporters.
Topics: Animals; Biological Transport; Cell Line; Humans; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Potassium | 2001 |
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
Topics: Animals; Choroid Plexus; Cimetidine; Enzyme Inhibitors; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Penicillins; Rats; Rats, Sprague-Dawley | 2002 |
Role of human organic anion transporter 4 in the transport of ochratoxin A.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Humans; Immunohistochemistry; Kidney; Liver-Specific Organic Anion Transporter 1; Mice; Ochratoxins; Organic Anion Transporters, Sodium-Independent; Piroxicam; Probenecid; Recombinant Proteins; Transfection | 2002 |
Characterization of methotrexate transport and its drug interactions with human organic anion transporters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cells, Cultured; Humans; Indomethacin; Kinetics; Liver-Specific Organic Anion Transporter 1; Methotrexate; Mice; Mice, Transgenic; Nerve Tissue Proteins; Organic Anion Transporters, Sodium-Independent; Phenylbutazone; Potassium Channels; Potassium Channels, Tandem Pore Domain; Probenecid | 2002 |
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.
Topics: Animals; Blood-Brain Barrier; Cimetidine; Convulsants; Endothelium, Vascular; Enzyme Inhibitors; Homovanillic Acid; Indican; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Rats; Rats, Wistar; Transfection; Tritium; Xenopus laevis | 2003 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Biological Transport; Cell Line, Transformed; Humans; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Solubility; Structure-Activity Relationship | 2013 |
Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide.
Topics: Animals; Evolution, Molecular; Glycosylation; Gonadal Steroid Hormones; HEK293 Cells; Humans; Ion Transport; Organic Anion Transporters; Protein Multimerization; Zebrafish; Zebrafish Proteins | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A study of the mechanism of transport of benzylpenicillin in the rat submaxillary gland.
Topics: Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Inulin; Male; Oxygen Consumption; Penicillin G; Penicillins; Probenecid; Rats; Submandibular Gland; Time Factors | 1978 |
Gonorrhea: recommended treatment schedules.
Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Female; Gonorrhea; Humans; Infant, Newborn; Male; Penicillin G; Pharyngeal Diseases; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Spectinomycin; Syphilis Serodiagnosis; Tetracycline; Urethra | 1975 |
Gonorrhea. Recommended treatment schedules--1974.
Topics: Adolescent; Adult; Age Factors; Ampicillin; Anti-Bacterial Agents; Cefazolin; Child; Child, Preschool; Endophthalmitis; Erythromycin; Female; Follow-Up Studies; Gonorrhea; Hospitalization; Humans; Infant; Infant, Newborn; Male; Penicillin G; Penicillin G Procaine; Pharyngeal Diseases; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Sex Factors; Spectinomycin; Tetracycline | 1975 |
Faucial bonorrhoea.
Topics: Adolescent; Adult; Age Factors; Ampicillin; Attitude to Health; Australia; Complement Fixation Tests; Female; Gonorrhea; Homosexuality; Humans; Male; Penicillin G; Pharyngeal Diseases; Probenecid; Sexual Behavior; Spectinomycin | 1975 |
National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results.
Topics: Ampicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Probenecid; Spectinomycin; Tetracycline | 1976 |
Penicillin levels in blood and CSF achieved by treatment of syphilis.
Topics: Administration, Oral; Humans; Injections, Intramuscular; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Penicillins; Probenecid; Syphilis; Syphilis, Congenital; Syphilis, Latent; Treponema pallidum | 1979 |
The enhancement of beta-lactam antibiotic therapy by novobiocin.
Topics: Animals; Cephaloridine; Cephalosporins; Drug Interactions; Female; Mice; Novobiocin; Penicillin G; Probenecid; Salmonella Infections, Animal | 1977 |
Mandibular actinomycosis: report of case.
Topics: Actinomyces; Actinomycosis, Cervicofacial; Adult; Alcoholism; Anesthesia, Local; Female; Fracture Fixation; Humans; Mandibular Diseases; Mandibular Fractures; Penicillin G; Penicillin G Procaine; Penicillin V; Penicillins; Postoperative Complications; Probenecid; Radiography; Staphylococcus; Streptococcus | 1975 |
Structural and functional studies of ligandin, a major renal organic anion-binding protein.
Topics: Amino Acids; Aminohippuric Acids; Animals; Bilirubin; Binding, Competitive; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Gel; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Glutathione; Immunodiffusion; Kidney; Ligands; Male; Penicillin G; Penicillins; Phenolsulfonphthalein; Phlorhizin; Probenecid; Protein Binding; Proteins; Rats; Spectrophotometry; Sulfobromophthalein | 1975 |
Penicillin transport from cerebrospinal fluid.
Topics: Animals; Biological Transport, Active; Cerebral Ventricles; Penicillin G; Probenecid; Rabbits | 1976 |
Extraction of antibiotics from the circulation by liver and kidney: effect of probenecid.
Topics: Animals; Anti-Bacterial Agents; Bile; Biological Assay; Blood Flow Velocity; Cephalothin; Chromium Radioisotopes; Dogs; Kidney; Liver; Lymph; Nafcillin; Penicillin G; Portal Vein; Probenecid; Staphylococcus | 1975 |
Gonorrhea: recommended treatment schedules-1974. Part II: Disseminated gonococcal infection and gonococcal infection in pediatric patients.
Topics: Ampicillin; Anti-Bacterial Agents; Child; Child Abuse; Erythromycin; Female; Gonorrhea; Hospitalization; Humans; Immobilization; Infant, Newborn; Infant, Newborn, Diseases; Ophthalmia Neonatorum; Penicillin G; Penicillin G Procaine; Pregnancy; Probenecid; Tetracycline | 1975 |
[High dosage short-infusion of penicillin G for one-time therapy of gonorrhea].
Topics: Adult; Gonorrhea; Humans; Male; Penicillin G; Probenecid | 1976 |
Effects of organic acids on the edema of the stria vascularis induced by furosemide.
Topics: Acids; Animals; Cochlear Diseases; Edema; Evoked Potentials, Auditory; Furosemide; Microscopy, Electron; Penicillin G; Probenecid; Sodium Salicylate; Stria Vascularis | 1992 |
Effects of organic acids on stria vascularis ultrastructure and function in the chinchilla.
Topics: Animals; Chinchilla; Cochlear Microphonic Potentials; Edema; Furosemide; Injections, Intravenous; Microscopy, Electron; Penicillin G; Probenecid; Sodium Salicylate; Stria Vascularis | 1992 |
J774 macrophages secrete antibiotics via organic anion transporters.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Carrier Proteins; Cell Line; Cell Membrane Permeability; Fluorescent Dyes; Isoquinolines; Macrophages; Mice; Norfloxacin; Penicillin G; Probenecid | 1992 |
In vivo evidence for carrier-mediated uptake of beta-lactam antibiotics through organic anion transport systems in rat kidney and liver.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Dose-Response Relationship, Drug; Kidney; Liver; Male; p-Aminohippuric Acid; Penicillin G; Probenecid; Rats; Rats, Inbred Strains | 1990 |
Organic acids do not alter the cochlear effects of ethacrynic acid.
Topics: Action Potentials; Animals; Aspirin; Chinchilla; Cochlea; Ethacrynic Acid; Female; Male; Penicillin G; Probenecid | 1990 |
[The level of penicillin in the blood serum during treatment of gonococcal infection with various doses of bicillin-3 and its combination with etamid].
Topics: Adolescent; Adult; Drug Therapy, Combination; Gonorrhea; Humans; Male; Middle Aged; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Probenecid; Urethritis | 1989 |
Facilitated transport of benzylpenicillin through the blood-brain barrier in rats.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Ceftriaxone; Drug Interactions; Male; Penicillin G; Probenecid; Rats; Rats, Inbred Strains | 1989 |
[Treatment of male non-complicated acute gonorrhea with a single dose of a combination of sodium penicillin and clemizolpenicillin, plus probenecid].
Topics: Acute Disease; Adolescent; Adult; Benzimidazoles; Drug Combinations; Drug Therapy, Combination; Gonorrhea; Humans; Male; Middle Aged; Penicillin G; Penicillins; Probenecid | 1987 |
Some organic acids attenuate the effects of furosemide on the endocochlear potential.
Topics: Animals; Biological Transport; Carboxylic Acids; Chinchilla; Choline; Cochlear Microphonic Potentials; Evoked Potentials, Auditory; Furosemide; Niacinamide; Penicillin G; Probenecid; Salicylates | 1987 |
Clinical experience in the use of clavulanic acid/penicillin regimens in the treatment of uncomplicated gonorrhoea.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Clavulanic Acids; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Probenecid | 1986 |
Penicillin concentrations in cerebrospinal fluid (CSF) during repository treatment regimen for syphilis.
Topics: Drug Therapy, Combination; Humans; Neurosyphilis; Penicillin G; Penicillin G Procaine; Probenecid; Syphilis | 1988 |
The effect of probenecid on the renal tubular excretion of benzylpenicillin.
Topics: Adult; Female; Glomerular Filtration Rate; Humans; Infusions, Intravenous; Kidney Tubules; Male; Mathematics; Models, Biological; Penicillin G; Probenecid | 1988 |
Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake.
Topics: Amino Acids; Animals; Anions; Cattle; Cephalosporins; In Vitro Techniques; Kinetics; Liver; Male; p-Aminohippuric Acid; Penicillin G; Peptides; Probenecid; Rats; Rats, Inbred Strains; Serum Albumin; Serum Albumin, Bovine; Sodium; Taurocholic Acid | 1986 |
Three regimens of procaine penicillin G, Augmentin, and probenecid compared for treating acute gonorrhoea in men.
Topics: Acute Disease; Administration, Oral; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Clavulanic Acids; Drug Combinations; Gonorrhea; Humans; Injections, Intramuscular; Male; Penicillin G; Penicillin G Procaine; Probenecid | 1986 |
Determination of benzylpenicillin and probenecid in human body fluids by high-performance liquid chromatography.
Topics: Body Fluids; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Penicillin G; Probenecid; Spectrophotometry, Ultraviolet | 1986 |
[Effect of probenecid and etamid on the penicillin levels of the blood serum and cerebrospinal fluid in experimental animals].
Topics: Animals; Biological Availability; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Male; Penicillin G; Probenecid; Rabbits; Syphilis; Time Factors | 1985 |
Oral ampicillin in uncomplicated gonorrhoea. 3. Results of treatment in women with positive rectal culture.
Topics: Administration, Oral; Ampicillin; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Probenecid; Rectum | 1971 |
Treatment of gonorrhoea with aqueous benzyl penicillin plus probenecid.
Topics: Adolescent; Adult; Drug Hypersensitivity; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Male; Middle Aged; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Probenecid; Rectum; Streptomycin; Syphilis; Syphilis Serodiagnosis; Tetracycline | 1971 |
Oral ampicillin in uncomplicated gonorrhoea. IV. Comparison of pharmacological and clinical results.
Topics: Administration, Oral; Ampicillin; Dosage Forms; Drug Combinations; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Penicillin G; Probenecid; Tablets; Time Factors | 1971 |
Initial therapy with combination of five antibiotics in febrile patients with leukaemia and neutropenia.
Topics: Administration, Oral; Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Bacterial Infections; Carbenicillin; Cephalothin; Clindamycin; Drug Combinations; Drug Hypersensitivity; Escherichia coli Infections; Fever; Gentamicins; Humans; Injections, Intravenous; Kanamycin; Klebsiella Infections; Leukemia; Leukocyte Count; Lymphoma; Methicillin; Penicillin G; Penicillin Resistance; Polymyxins; Probenecid; Pseudomonas Infections; Staphylococcal Infections | 1972 |
Oral ampicillin in uncomplicated gonorrhoea. V. Comparison of bacteriological and clinical results.
Topics: Administration, Oral; Ampicillin; Female; Gonorrhea; Humans; In Vitro Techniques; Injections, Intramuscular; Male; Microbial Sensitivity Tests; Penicillin G; Probenecid; Sex Factors | 1972 |
Pivampicillin combined with probenecid in the treatment of acute uncomplicated gonorrhoea.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Ampicillin; Drug Therapy, Combination; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Male; Neisseria gonorrhoeae; Penicillin G; Probenecid; Recurrence; Valerates | 1973 |
Enterococcal lung abscess: medical and surgical therapy.
Topics: Ampicillin; Drainage; Enterococcus faecalis; Gentamicins; Humans; Lincomycin; Lung Abscess; Male; Microbial Sensitivity Tests; Middle Aged; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Pneumonia; Probenecid; Radiography; Streptococcal Infections; Streptococcus pneumoniae; Streptomycin | 1974 |
Experimental under-treatment of early syphilis with probenecid and penicillin in anti-gonorrhoea dosages. A study to assess the best follow-up examination time for syphilis after gonorrhoea treatment in Greenland.
Topics: Adult; Female; Gonorrhea; Greenland; Health Surveys; Humans; Male; Penicillin G; Probenecid; Syphilis | 1968 |
Neonatal gonococcal arthritis: three cases and review of the literature.
Topics: Arizona; Arthritis, Infectious; Female; Gonorrhea; Humans; Indians, North American; Infant, Newborn; Infant, Newborn, Diseases; Male; Neisseria gonorrhoeae; New Mexico; Penicillin G; Penicillin G Procaine; Probenecid; Sulfanilamides; Synovial Fluid | 1974 |
Penicillin treatment of gonorrhoea in Edinburgh.
Topics: Adolescent; Adult; Cervix Uteri; Female; Follow-Up Studies; Gonorrhea; Humans; Immunodiffusion; Male; Middle Aged; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Probenecid; Rectum; Scotland; Urethra | 1974 |
Gonorrhea.
Topics: Adolescent; Adult; Ampicillin; Diagnosis, Differential; Drug Therapy, Combination; Female; Gonorrhea; Humans; Infant, Newborn; Male; Neisseria gonorrhoeae; Ophthalmia Neonatorum; Pelvic Inflammatory Disease; Penicillin G; Penicillin Resistance; Penicillins; Pregnancy; Probenecid; United States | 1973 |
Resistance of Neisseria gonorrhoeae to penicillin in 199 gonococcal infections in women and the response of those infections to penicillin treatment.
Topics: Adolescent; Adult; Age Factors; Female; Follow-Up Studies; Gonorrhea; Humans; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae; Occupations; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Probenecid | 1974 |
Treatment of acute gonococcal urethritis in Bangkok, Thailand.
Topics: Acute Disease; Ampicillin; Drug Therapy, Combination; Gonorrhea; Humans; Injections, Intramuscular; Kanamycin; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Penicillins; Probenecid; Recurrence; Thailand; Urethritis | 1974 |
Comparison of amoxicillin and ampicillin in single-dose oral treatment of males with gonococcal urethritis.
Topics: Administration, Oral; Amines; Ampicillin; Diarrhea; Drug Evaluation; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Nausea; Neisseria gonorrhoeae; Penicillin G; Penicillins; Probenecid | 1974 |
Treatment of gonorrhea.
Topics: Ampicillin; Anti-Bacterial Agents; Gonorrhea; Humans; Penicillin G; Penicillin G Benzathine; Penicillin Resistance; Penicillins; Probenecid; Spectinomycin; Tetracycline | 1973 |
Cephaloridine: antimicrobial activity and pharmacologic behavior.
Topics: Adult; Alcaligenes; Cephaloridine; Cephalosporins; Cephalothin; Drug Synergism; Enterobacteriaceae; Enterococcus faecalis; Escherichia coli; Haemophilus influenzae; Humans; Klebsiella; Methicillin; Penicillin G; Probenecid; Proteus; Pseudomonas aeruginosa; Salmonella; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Tetracycline | 1967 |
[Bacterial heart infections in the child--their relation to sepsis].
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Electrocardiography; Endocarditis, Bacterial; Heart Sounds; Humans; Infant; Lincomycin; Methicillin; Myocarditis; Oxacillin; Penicillin G; Pericarditis; Probenecid; Sepsis; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Time Factors | 1974 |
Treatment of gonorrhoea with a combination of probenecid and sodium penicillin G among African Ugandans.
Topics: Adolescent; Adult; Drug Synergism; Female; Follow-Up Studies; Gonorrhea; Humans; Male; Middle Aged; Penicillin G; Penicillin Resistance; Probenecid; Uganda | 1972 |
Epidemiological measures against gonorrhoea. Experience in Greenland.
Topics: Adolescent; Adult; Female; Gonorrhea; Greenland; Humans; Injections, Intramuscular; Lidocaine; Male; Penicillin G; Probenecid | 1973 |
Treatment of gonorrhoea in Singapore using penicillin plus probenecid.
Topics: Gonorrhea; Humans; Kanamycin; Male; Penicillin G; Penicillin G Procaine; Probenecid; Singapore; Urethritis | 1973 |
Effects of probenecid on the distribution, elimination, and passage into milk of benzylpenicillin, ampicillin and cloxacillin.
Topics: Ampicillin; Animals; Biological Assay; Cloxacillin; Depression, Chemical; Female; Hydrogen-Ion Concentration; Injections, Intramuscular; Injections, Intravenous; Kinetics; Milk; Penicillin G; Probenecid; Sheep; Time Factors | 1974 |
Single-dose antibiotic treatment of asymptomatic gonorrhea in hospitalized women.
Topics: Administration, Oral; Ampicillin; Anti-Bacterial Agents; Female; Gonorrhea; Hospitalization; Humans; Injections, Intramuscular; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Penicillins; Probenecid; Tetracycline | 1970 |
Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid.
Topics: Adult; Anti-Bacterial Agents; Gonorrhea; Humans; Lidocaine; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Probenecid | 1970 |
Venereal disease in women. II.
Topics: Chancroid; Culture Media; Cytodiagnosis; Female; Folic Acid Antagonists; Gonorrhea; Humans; Kanamycin; Neisseria gonorrhoeae; Penicillin G; Physical Examination; Probenecid; Pyrimidines; Sulfamethoxazole; Vaginal Smears | 1971 |
Choice of penicillins for gonorrhoea.
Topics: Administration, Oral; Ampicillin; Gonorrhea; Humans; Injections; Penicillin G; Penicillin V; Penicillins; Probenecid | 1971 |
Clinical pharmacology of ampicillin and hetacillin.
Topics: Administration, Oral; Ampicillin; Animals; Anuria; Bile; Chemical Phenomena; Chemistry; Humans; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Kidney; Liver; Metabolism; Penicillin G; Penicillin V; Penicillins; Probenecid; Rats | 1967 |
[Therapy and therapy-control in uncomplicated gonorrhea].
Topics: Doxycycline; Erythromycin; Female; Gonorrhea; Humans; Leucomycins; Lincomycin; Male; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Penicillins; Probenecid; Rifampin; Tetracycline | 1971 |
Gonococcal tonsillar infections.
Topics: Ampicillin; Complement Fixation Tests; Denmark; Ethnicity; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Palatine Tonsil; Penicillin G; Probenecid; Sexual Behavior; Tetracycline; Tonsillitis | 1971 |
Effect of organic acid transport inhibitors on renal cortical uptake and proximal tubular toxicity of cephaloridine.
Topics: Acute Kidney Injury; Animals; Biological Transport; Cephaloridine; Female; Glomerular Filtration Rate; Kidney; Mannitol; Penicillin G; Probenecid; Rabbits | 1972 |
Drug elimination and apparent volume of distribution in multicompartment systems.
Topics: Biopharmaceutics; Drug Interactions; Half-Life; Humans; Injections, Intravenous; Kinetics; Mathematics; Models, Biological; Penicillin G; Probenecid; Time Factors | 1972 |
Effects of change in elimination on varous parameters of the two-compartment open model.
Topics: Drug Interactions; Half-Life; Humans; Kinetics; Mathematics; Models, Biological; Penicillin G; Pharmaceutical Preparations; Probenecid | 1972 |
Endocarditis due to a lanthanic, unclassified Gram-negative bacterium (group IV d).
Topics: Adult; Ampicillin; Bacteria; Chloramphenicol; Endocarditis, Bacterial; Humans; Male; Penicillin G; Penicillin Resistance; Probenecid; Sepsis | 1968 |
Activity of broad-spectrum antibiotics against enterococci and their efficacy in enterococcal endocarditis.
Topics: Administration, Oral; Ampicillin; Cephaloridine; Cephalothin; Chloramphenicol; Endocarditis, Bacterial; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Microbial Sensitivity Tests; Penicillin G; Probenecid; Streptococcus; Streptomycin; Tetracycline; Time Factors | 1967 |
Evidence of active transport of benzyl-14C-penicillin from cerebrospinal fluid to blood.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Cerebral Ventricles; Dogs; Injections; Penicillin G; Probenecid; Time Factors | 1969 |
Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined.
Topics: Ampicillin; Anaphylaxis; Drug Synergism; Gonorrhea; Humans; Injections, Intramuscular; Male; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Probenecid | 1969 |
Gonorrhea: the minimum effective dose.
Topics: Ampicillin; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Military Medicine; Penicillin G; Penicillin G Procaine; Penicillins; Probenecid; Tetracycline | 1970 |
Clinical pharmacology of carbenicillin compared with other penicillins.
Topics: Ampicillin; Anti-Bacterial Agents; Benzene Derivatives; Humans; Injections, Intravenous; Kidney; Liver; Penicillin G; Penicillins; Probenecid; Protein Binding; Pseudomonas Infections | 1970 |
Penicillins and aqueous humor.
Topics: Ampicillin; Animals; Aqueous Humor; Blood Chemical Analysis; Drug Synergism; Humans; Injections, Intramuscular; Penicillin G; Penicillin G Benzathine; Probenecid; Rabbits; Syphilis | 1968 |
[Gonorrhea therapy with a combination of probenecid and benzylsodiumpenicillin. A report from Greenland].
Topics: Female; Gonorrhea; Greenland; Humans; Male; Penicillin G; Probenecid | 1968 |
Gonorrhoea treated by a combination of probenecid and sodium penicillin G.
Topics: Drug Synergism; Female; Gonorrhea; Greenland; Humans; Male; Penicillin G; Penicillin Resistance; Probenecid; Sodium; Species Specificity | 1969 |
Complications in a patient with subacute bacterial endocarditis with particular reference to massive penicillin therapy.
Topics: Blood Protein Electrophoresis; Calcinosis; Embolism; Endocarditis, Subacute Bacterial; Femoral Artery; Heart Failure; Humans; Hypokalemia; Male; Middle Aged; Penicillin G; Potassium; Probenecid; Serum Albumin; Sodium; Vascular Diseases | 1969 |
Probenecid as an aid to penicillin therapy.
Topics: Aminosalicylic Acids; Cephalothin; Cloxacillin; Erythromycin; Humans; Methicillin; Penicillin G; Penicillin G Benzathine; Probenecid; Sulfonamides | 1966 |
Blood-brain and CSF barriers to penicillin and related organic acids.
Topics: Acetates; Aminohippuric Acids; Animals; Blood-Brain Barrier; Carbon Isotopes; Cerebrospinal Fluid; Dogs; In Vitro Techniques; Injections, Intravenous; Penicillin G; Phenolphthaleins; Probenecid; Protein Binding; Radiometry; Rats; Uric Acid | 1966 |
[The gonorrhea situation in Greenland and the epidemiological control of this disease].
Topics: Adolescent; Adult; Female; Gonorrhea; Greenland; Humans; Male; Penicillin G; Probenecid; Sexual Behavior | 1966 |
Gonorrhoea among prostitutes.
Topics: Adult; Australia; Female; Gonorrhea; Humans; Middle Aged; Penicillin G; Penicillin G Procaine; Probenecid; Sex Work | 1967 |
Neurotoxicity and "massive" intravenous therapy with penicillin. A study of possible predisposing factors.
Topics: Adolescent; Adult; Aged; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Coma; Female; Humans; Infant; Injections, Intravenous; Kidney Diseases; Male; Middle Aged; Movement Disorders; Penicillin G; Probenecid; Retrospective Studies; Seizures; Water-Electrolyte Balance | 1967 |
Detection of repeated gonorrhea by a modified follow-up method.
Topics: Ampicillin; Coitus; Drug Therapy, Combination; Female; Follow-Up Studies; Gonorrhea; Humans; Interview, Psychological; Male; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Pivampicillin; Probenecid; Recurrence; Retrospective Studies; Time Factors | 1982 |
The penicillins.
Topics: Amoxicillin; Ampicillin; Bacterial Infections; Carbenicillin; Drug Administration Schedule; Drug Evaluation; Drug Hypersensitivity; Drug Synergism; Humans; Penicillin G; Penicillins; Piperacillin; Probenecid; Ticarcillin | 1983 |
Medical management of visceral actinomycosis.
Topics: Abscess; Actinomycosis; Adult; Diagnosis, Differential; Drug Therapy, Combination; Female; Gingival Crevicular Fluid; Humans; Kidney Diseases; Lumbar Vertebrae; Penicillin G; Probenecid; Pulmonary Embolism; Retroperitoneal Space; Tomography, X-Ray Computed | 1983 |
Influence of probenecid on serum and subcutaneous tissue fluid concentrations of benzylpenicillin and ceftazidime in human volunteers.
Topics: Adult; Ceftazidime; Cephalosporins; Humans; Kinetics; Penicillin G; Probenecid | 1983 |
Probenecid: antibacterial action against Neisseria gonorrhoeae and interaction with benzylpenicillin.
Topics: Anti-Bacterial Agents; Culture Media; Drug Interactions; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Probenecid | 1984 |
Penicillin concentrations in serum and cerebrospinal fluid after intramuscular injection of aqueous procaine penicillin 0.6 MU with and without probenecid.
Topics: Biological Assay; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Male; Penicillin G; Penicillin G Procaine; Penicillins; Probenecid; Syphilis | 1984 |
Prolonged use of the Greenland method of treatment of gonorrhoea.
Topics: Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Penicillins; Probenecid; Species Specificity | 1980 |
Extension of the blood half-life of glyceryl trinitrate. Inhibition of glutathione organic nitrate ester reductase activity in the rat and guinea pig.
Topics: Animals; Cephalothin; Female; Glutathione Transferase; Guinea Pigs; Half-Life; In Vitro Techniques; Kinetics; Liver; Nitroglycerin; Penicillin G; Probenecid | 1980 |
Reactivity and binding of beta-lactam antibiotics in rabbit renal cortex.
Topics: Animals; Anti-Bacterial Agents; Cephaloglycin; Cephalothin; Female; Kidney Cortex; Kinetics; Microsomes; Penicillin G; Probenecid; Rabbits; Subcellular Fractions | 1983 |
Treatment of gonorrhoea.
Topics: Drug Therapy, Combination; Gonorrhea; Humans; Lidocaine; Male; Penicillin G; Probenecid | 1981 |
Secondary syphilitic uveitis.
Topics: Aqueous Humor; Fluorescent Antibody Technique; Humans; Male; Middle Aged; Penicillin G; Probenecid; Syphilis; Treponema pallidum; Uveitis; Visual Fields | 1981 |
Incidence of asymptomatic gonorrhoea in antenatal patients, Auki, Solomon Islands.
Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Melanesia; Penicillin G; Pregnancy; Pregnancy Complications, Infectious; Probenecid | 1982 |
Treatment of bacterial meningitis in children without intravenous fluids.
Topics: Administration, Oral; Anti-Bacterial Agents; Chloramphenicol; Humans; Infant; Injections, Intramuscular; Meningitis; Penicillin G; Probenecid; Prospective Studies | 1981 |
[The combination of Jenacellin A and probenecid for treatment of gonorrhoea (author's transl)].
Topics: Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Penicillin G; Penicillin G Procaine; Probenecid | 1981 |
Effects of probenecid on plasma/tissue distribution of 14C-benzylpenicillin in rats.
Topics: Animals; Kidney; Liver; Male; Penicillin G; Probenecid; Rats | 1980 |
Serum and subcutaneous chamber fluid dynamics of penicillins after single large parenteral doses.
Topics: Amoxicillin; Animals; Body Fluids; Drug Implants; Injections; Injections, Intramuscular; Male; Penicillin G; Penicillins; Probenecid; Rabbits; Skin | 1980 |
Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Probenecid; Syphilis | 1980 |
[Simultaneous therapy of gonorrhea with penicillin and probenecid. Serum penicillin picture].
Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Middle Aged; Penicillin G; Probenecid | 1980 |
Effect of active transport on distribution and concentration gradients of [3H]benzylpenicillin in the cerebrospinal fluid.
Topics: Animals; Biological Transport, Active; Cisterna Magna; Dogs; Injections, Intraventricular; Penicillin G; Probenecid | 1994 |
Active transport of benzylpenicillin across the blood-milk barrier.
Topics: Absorption; Animals; Biological Transport, Active; Blood; Cattle; Chromatography, High Pressure Liquid; Epithelium; Female; Goats; Half-Life; Infusions, Intravenous; Infusions, Parenteral; Mammary Glands, Animal; Milk; Penicillin G; Probenecid | 1993 |
Primary abdominal actinomycosis.
Topics: Abdominal Muscles; Actinomycosis; Aged; Female; Humans; Laparotomy; Metronidazole; Penicillin G; Penicillin V; Probenecid | 1993 |
Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.
Topics: Animals; Anions; Carrier Proteins; Cell Membrane Permeability; Chlorides; Female; Kidney Tubules, Proximal; Membrane Potentials; Microvilli; Oocytes; Patch-Clamp Techniques; Penicillin G; Phenolsulfonphthalein; Probenecid; Recombinant Proteins; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type I; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters; Xenopus laevis | 1996 |
Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anti-Infective Agents; Binding, Competitive; Biological Transport, Active; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Choroid Plexus; Enzyme Inhibitors; Fleroxacin; Ion Transport; Isotope Labeling; Male; Ouabain; Penicillin G; Penicillins; Probenecid; Rats; Rats, Wistar; Renal Agents; Rotenone; Sulfhydryl Reagents; Uncoupling Agents | 1996 |
Probenecid inhibits platelet responses to aggregating agents in vitro and has a synergistic inhibitory effect with penicillin G.
Topics: Calcium; Drug Synergism; Humans; In Vitro Techniques; Ion Channels; Penicillin G; Penicillins; Platelet Aggregation Inhibitors; Probenecid; Serotonin; Uricosuric Agents; Whole Blood Coagulation Time | 1996 |
Active transport properties of porcine choroid plexus cells in culture.
Topics: Animals; Anions; Ascorbic Acid; Bicarbonates; Biological Transport, Active; Blood-Brain Barrier; Body Fluids; Cell Polarity; Cells, Cultured; Choroid Plexus; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Epithelial Cells; Fluorescein; Inositol; Kinetics; Microscopy, Electron; Penicillin G; Penicillins; Phenolsulfonphthalein; Probenecid; Renal Agents; Riboflavin; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Swine | 1998 |
Homeostatic role of the active transport in elimination of [3H]benzylpenicillin out of the cerebrospinal fluid system.
Topics: Animals; Biological Transport, Active; Cerebrospinal Fluid; Dogs; Models, Animal; Penicillin G; Penicillins; Probenecid | 2000 |
Oral potassium penicillin G combined with probenecid in the treatment of gonorrhea in the male.
Topics: Gonorrhea; Humans; Male; Penicillin G; Penicillins; Potassium; Probenecid | 1957 |
Current concepts in therapy. Hemolytic anemia.
Topics: Adrenocorticotropic Hormone; Anemia; Anemia, Hemolytic; Chelating Agents; Cortisone; Erythropoiesis; Penicillin G; Prednisone; Probenecid; Splenectomy; Sulfhydryl Compounds | 1963 |
ENHANCEMENT OF ANTIMICROBIAL ACTIVITY OF PENICILLINS AND OTHER ANTIBIOTICS IN HUMAN SERUM BY COMPETITIVE SERUM BINDING INHIBITORS.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Antipyrine; Cephalothin; Humans; Methicillin; Naphthalenes; Oxacillin; Penicillamine; Penicillin G; Penicillin V; Penicillins; Pharmacology; Probenecid; Salicylates; Staphylococcus; Sulfonamides | 1964 |
INHIBITORS OF PENICILLIN BINDING TO SERUM PROTEINS.
Topics: Acetazolamide; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimetabolites; Aspirin; Benzoates; Biguanides; Blood Proteins; Carbon Isotopes; Chlorothiazide; Diuretics; Ethacrynic Acid; Guanidines; Oxazoles; p-Aminohippuric Acid; Penicillin G; Penicillin V; Penicillins; Pharmacology; Phenylbutazone; Probenecid; Rabbits; Research; Salicylates; Sulfinpyrazone; Sulfonamides; Tolbutamide | 1965 |
[PRESENT STATUS OF THE TREATMENT OF STAPHYLOCOCCAL DISEASES].
Topics: Anti-Bacterial Agents; Cross Infection; Drug Therapy; Humans; Methicillin; Oxacillin; Penicillin G; Penicillins; Probenecid; Rifamycins; Staphylococcal Infections; Vancomycin | 1965 |
[Therapy of syphilis].
Topics: Adult; Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Controlled Clinical Trials as Topic; Doxycycline; Female; Follow-Up Studies; Humans; Male; Neurosyphilis; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Practice Guidelines as Topic; Pregnancy; Probenecid; Prospective Studies; Syphilis; Syphilis Serodiagnosis; Time Factors; Uricosuric Agents | 2004 |
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cerebrospinal Fluid; Choroid Plexus; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Male; Models, Molecular; Molecular Structure; Organic Cation Transport Proteins; Penicillin G; Probenecid; Ranitidine; Rats; Rats, Sprague-Dawley; Static Electricity; Tetraethylammonium; Tritium | 2004 |
Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Biological Transport; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Estrone; GABA Modulators; Herbicides; Mice; Ochratoxins; Organic Anion Transporters; p-Aminohippuric Acid; Penicillin G; Probenecid; Salicylates; Transfection; Uricosuric Agents; Xenopus laevis | 2006 |
Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
Topics: Adenosine Triphosphate; Angiotensin II Type 1 Receptor Blockers; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Dogs; Dose-Response Relationship, Drug; Estrone; Female; Hepatocytes; Humans; Imidazoles; In Vitro Techniques; Kidney; Kinetics; Liver; Liver-Specific Organic Anion Transporter 1; Membrane Transport Proteins; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Olmesartan Medoxomil; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Probenecid; Prodrugs; Protein Binding; Protein Isoforms; Sincalide; Solute Carrier Organic Anion Transporter Family Member 1B3; Tetrazoles; Transfection | 2007 |
Stroke in pregnancy associated with syphilis.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Female; Gestational Age; Humans; Magnetic Resonance Imaging; Penicillin G; Penicillin G Procaine; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Complications, Infectious; Probenecid; Stroke; Syphilis | 2008 |
Brain efflux index to investigate the influence of active efflux on brain distribution of pemetrexed and methotrexate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Capillary Permeability; Folic Acid Antagonists; Glutamates; Guanine; Half-Life; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Pemetrexed; Penicillin G; Probenecid | 2013 |
Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs.
Topics: Aniline Compounds; Animals; Benzenesulfonates; Biological Transport; Dogs; Female; Kidney; Male; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Penicillin G; Probenecid; Rats; Rats, Sprague-Dawley; Species Specificity; Temperature; Xenopus laevis | 2013 |
Penicillin Encephalopathy: An Unlikely Adversary in the Treatment of Neurosyphilis--Case Report and Review of the Literature.
Topics: Adjuvants, Pharmaceutic; Aged; Anti-Bacterial Agents; Brain Diseases; Female; HIV Infections; Humans; Neurosyphilis; Penicillin G; Probenecid; Renal Insufficiency; Syphilis Serodiagnosis; Treatment Outcome | 2016 |
Investigation of Endogenous Compounds Applicable to Drug-Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans.
Topics: Adult; Animals; Cell Line; Drug Interactions; HEK293 Cells; Humans; Hydrocortisone; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Penicillin G; Probenecid; Taurine; Young Adult | 2016 |
Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.
Topics: Acyclovir; Anti-Bacterial Agents; Antiviral Agents; Drug Interactions; Ganciclovir; HEK293 Cells; Humans; Kidney; Models, Biological; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Oseltamivir; Penicillin G; Probenecid; Renal Elimination; Tenofovir; Transfection | 2017 |
Neurosyphilis Treatment Outcomes After Intravenous Penicillin G Versus Intramuscular Procaine Penicillin Plus Oral Probenecid.
Topics: HIV Infections; Humans; Neurosyphilis; Penicillin G; Penicillin G Procaine; Probenecid; Treatment Outcome | 2020 |