probenecid has been researched along with p-aminohippuric acid in 192 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 98 (51.04) | 18.7374 |
| 1990's | 45 (23.44) | 18.2507 |
| 2000's | 38 (19.79) | 29.6817 |
| 2010's | 11 (5.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graves, P; Kuze, K; Leahy, A; Stuhlmann, H; Wilson, P; You, G | 1 |
| Chan, BS; Lu, R; Schuster, VL | 1 |
| Grassl, SM; Holtzman, EJ; Race, JE; Williams, WJ | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kimura, M; Sekine, T; Takeda, M; Tsuda, M | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Endou, H; Hosoyamada, M; Kanai, Y; Sekine, T; Takeda, M; Tojo, A | 1 |
| Cihlar, T; Ho, ES | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Abe, T; Endou, H; Kusuhara, H; Meier, PJ; Sekine, T; Shitara, Y; Sugiyama, D; Sugiyama, Y; Suzuki, H | 1 |
| Akhoundova, A; Arndt, P; Bamberg, E; Budiman, T; Gorboulev, V; Koepsell, H; Koppatz, S; Nagel, G; Popp, C; Ulzheimer-Teuber, I; Volk, C | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Jung, KY; Kim, DK; Narikawa, S; Sekine, T; Takeda, M; Tojo, A; Yoo, BS | 1 |
| Endou, H; Kusuhara, H; Nagata, Y; Sugiyama, Y | 1 |
| Babu, E; Cha, SH; Endou, H; Enomoto, A; Kobayashi, Y; Narikawa, S; Sakthisekaran, D; Sekine, T; Takeda, M; Tojo, A | 1 |
| Endou, H; Hosoya, T; Hosoyamada, M; Ichida, K; Kimura, H; Takeda, M; Utsunomiya, Y | 1 |
| Deguchi, T; Hosoya, K; Kang, YS; Mori, S; Ohtsuki, S; Takanaga, H; Terasaki, T | 1 |
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Eraly, SA; Kaler, G; Khandelwal, A; Nagle, M; Nigam, SK; Swaan, PW; Truong, DM | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Beyer, KH; Bohn, DL; Fanelli, GM; Scriabine, A | 1 |
| Bohn, DL; Fanelli, GM; Zacchei, AG | 1 |
| Jacobsen, C; Maxild, J; Møller, JV; Sheikh, MI | 1 |
| Jacobsen, C; Sheikh, MI; Stahl, M | 2 |
| Stone, RA | 1 |
| Fanelli, GM; Weiner, IM | 1 |
| Berndt, WO | 1 |
| Weiner, IM | 1 |
| Diamond, HS; Holden, D; Meisel, AD | 1 |
| Coleridge, J; Handschumacher, RE | 1 |
| Hoshi, T; Kikuta, Y | 1 |
| Gale, GR; Ross, DA | 1 |
| Trimble, ME | 3 |
| Irish, JM | 1 |
| Deetjen, P; Greger, R; Lang, F; Oberleithner, H | 1 |
| Kleinschmidt, A; Schräpler, P; Schulz, E | 1 |
| Cacini, W; Quebbemann, AJ | 1 |
| Hautmann, R; Osswald, H | 1 |
| Bräunlich, H; Hartwich, R; Stopp, M | 1 |
| Lifschitz, MD; Patak, RV; Rosenblatt, SG | 1 |
| Maxild, J; Sheikh, MI | 1 |
| Acara, M; Koschier, FJ | 1 |
| Oldendorf, WH; Pardridge, WM | 1 |
| Diamond, HS; Meisel, AD | 2 |
| Foulkes, EC | 1 |
| Sheikh, MI; Stahl, M | 1 |
| Bräunlich, H; Storch, R | 2 |
| Clifton, G; Kaplowitz, N; Kuhlenkamp, J; Wallin, JD | 1 |
| Choi, TL; Kim, YK | 1 |
| Cloutier, MM; Guernsey, L | 1 |
| Miller, JH | 1 |
| Jung, DK; Jung, JS; Kim, YK; Lee, SH | 1 |
| Fujitani, T; Tada, Y; Yoneyama, M | 1 |
| Grantham, JJ; Sullivan, LP | 1 |
| Fritzsch, G; Klöss, S; Papavassiliou, F; Rumrich, G; Ullrich, KJ | 1 |
| Chakrabarti, S; Côté, MG; Vu, DD | 1 |
| Hori, R; Kamiya, A; Okamura, N; Saito, Y; Shimizu, H; Tanigawara, Y | 1 |
| Guisan, B; Roch-Ramel, F; Werner, D | 2 |
| Giorgi, G; Segre, G; Urso, R | 1 |
| Hierholzer, K; Papavassiliou, F; Rumrich, G; Ullrich, KJ | 1 |
| Chakrabarti, S; Côté, MG; Guo, WX; Malick, MA | 1 |
| Blanck, S; Foulkes, EC | 1 |
| He, YL; Hori, R; Kamiya, A; Saito, Y; Tanigawara, Y | 1 |
| de Laet, RC; Heijn, M; Russel, FG; van Ginneken, CA | 1 |
| Ennis, SR | 1 |
| Kwon, HM | 1 |
| Takeda, K; Tamai, I; Terasaki, T; Tsuji, A | 1 |
| Haylor, J; Lote, CJ; Thewles, A; Towers, JD | 1 |
| Dawson, MA; Renfro, JL | 1 |
| Jakobson, AM | 1 |
| Bernhardt, H; Bernhardt, I; Bräunlich, H | 1 |
| Brendel, K; Gandolfi, AJ; Stevens, JL; Wolfgang, GH | 1 |
| Edmonds, B; Mamelok, RD; Tse, SS | 1 |
| de Bold, AJ; Goldinger, JM; Hong, RB; Hong, SK; Lee, SH | 1 |
| Blaufox, MD; Lee, HB | 1 |
| Kahn, AM; Weinman, EJ | 1 |
| Cheeks, C; Wedeen, RP | 1 |
| Burckhardt, G; Moewes, B; Shimada, H | 1 |
| Benet, LZ; Gloff, CA; Mamelok, RD | 1 |
| Haylor, J; Lote, CJ; Towers, JD | 1 |
| Brown, MP; Gronwall, R | 1 |
| Brater, DC; de Zeeuw, D; Jacobson, HR | 1 |
| Diamond, GL; Klotzbach, JM | 1 |
| Heijn, M; Russel, FG; van der Linden, PE; van Ginneken, CA; van Os, CH; Vermeulen, WG | 1 |
| Goldinger, JM; Hong, SK; Taub, M; Yang, IS | 1 |
| MacDougall, ML; Wiegmann, TB | 1 |
| Christensen, S; Petersen, JS | 1 |
| Bito, LZ; DiBenedetto, FE | 1 |
| Cacini, W | 1 |
| Bidiville, J; Roch-Ramel, F | 1 |
| Nakashima, E; Takanosu, K; Tamai, I; Terasaki, T; Tsuji, A | 1 |
| Edwards, RM; Grantham, JJ; Webb, DE | 1 |
| Comin, EJ; Elías, MM; Ochoa, EJ; Rodríguez Garay, EA | 1 |
| Donoso, VS; Grantham, JJ | 1 |
| Quebbemann, AJ; Tremaine, LM | 1 |
| Bird, JE; Quebbemann, AJ; Tremaine, LM | 1 |
| Goldinger, JM; Hong, SK; Lee, SH | 1 |
| Qiu, JP; Wong, PY | 1 |
| Hirose, T; Mine, Y; Nakamoto, S; Sakamoto, H | 1 |
| Cacini, W; Myre, SA | 1 |
| Kahn, AM; Shelat, H; Weinman, EJ | 1 |
| Denef, J; Ghys, A; Kramp, RA; Lenoir, RH | 1 |
| Kawabata, T; Miyahara, T; Nakamura, M; Shimada, J; Sugeno, K; Ueda, Y; Yamaji, T; Yoshida, T | 1 |
| Ehrlich, BE; Wright, EM | 1 |
| Branham, S; Kahn, AM; Weinman, EJ | 1 |
| Herbert, BH; Nelson, JA; Santos, G | 1 |
| Bildstein, C; Liu, D; Mamelok, RD; Tse, SS | 1 |
| Bildstein, CL; Liu, D; Mamelok, RD; Tse, SS | 2 |
| Møller, JV; Sheikh, MI | 1 |
| Aronson, PS; Kahn, AM | 1 |
| Appenroth, D; Bräunlich, H | 1 |
| Nierenberg, DW | 1 |
| Cacini, W; Grund, VR; Keller, MB | 1 |
| Aonuma, K; Ito, Y; Matsuda, O; Shiigai, T; Takeuchi, J | 1 |
| Berndt, WO; Hayes, AW | 1 |
| Hori, R; Inui, K; Kitazawa, S; Okano, T; Takano, M | 1 |
| Klöss, S; Rumrich, G; Ullrich, KJ | 1 |
| Knight, TF; Sansom, SC; Senekjian, HO; Weinman, EJ | 1 |
| Chonko, AM; Grantham, JJ; Shimomura, A | 1 |
| Appenroth, D; Bräunlich, H; Splinter, K; Zaumseil, J | 1 |
| Roch-Ramel, F; Schäli, C | 2 |
| Brand, PH; Stansbury, R | 1 |
| Henry, DP; Lappe, RW; Willis, LR | 1 |
| Dantzler, WH; Evans, KK; Wright, SH | 1 |
| Bindels, RJ; Masereeuw, R; Russel, FG; van den Bergh, EJ | 1 |
| Franz, HE; Gründemann, D; Kienle, S; Koepsell, H; Scheyerl, F; Steffgen, J | 1 |
| Burckhardt, G; Schmitt, C | 1 |
| Ammer, U; Natochin, Yu; Ullrich, KJ | 1 |
| Greven, J; Haller, S; Kutzer, M; Meer, S | 1 |
| Costigan, MG; Lindup, WE | 1 |
| Bahnemann, E; Ensminger, S; Gekle, M; Kerling, HP; Schwerdt, G; Silbernagl, S | 1 |
| Aungst, BJ; Fujisaki, H; Miyazaki, K; Saitoh, H | 1 |
| Ehlert, C; Seydel, JK; Strunz, H; Visser, K; Wiese, M | 1 |
| Hashimoto, Y; Inui, K; Nagai, J; Takano, M; Yano, I | 1 |
| Hashimoto, Y; Inui, K; Okuda, M; Takami, K; Uwai, Y | 1 |
| Chatsudthipong, V; Dantzler, WH; Evans, KK; Jutabha, P | 1 |
| Masereeuw, R; Miller, DS; Moons, MM; Russel, FG; Toomey, BH | 1 |
| Edwards, RM; Stack, EJ; Trizna, W | 1 |
| Beery, E; Bornstein, SR; Burckhardt, G; Ersoy, D; Jarry, H; Metten, M; Müller, GA; Rohrbach, S; Steffgen, J | 1 |
| Burckhardt, BC; Burckhardt, G; Wolff, NA | 1 |
| Linton, SM; O'Donnell, MJ | 1 |
| Jo, OD; Said, HM; Shih, RN; Yanagawa, N | 1 |
| Naruhashi, K; Sai, Y; Suzuki, N; Tamai, I; Tsuji, A | 1 |
| Barrett, J; Cihlar, T; Hill, G; Ho, ES; Liu, B; Oo, C; Prior, K; Ward, P; Wiltshire, H | 1 |
| Gibbs, JE; Thomas, SA | 1 |
| Asaba, H; Deguchi, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Beier, DR; Fujiwara, Y; Miller, DS; Nigam, SK; Pritchard, JB; Sweet, DH | 1 |
| Chan, LM; Miller, DS; Pritchard, JB; Sweet, DH; Walden, R; Yang, XP | 1 |
| Habu, Y; Hashimoto, Y; Inui, K; Saito, H; Yano, I | 1 |
| ARNING, R; SCHOOG, M | 1 |
| BERGLUND, F; FORSTER, RP | 1 |
| HAKKINEN, I; HARTIALA, K; KASANEN, A; VANHA-PERTTULA, T | 1 |
| HAEKKINEN, I; HARTIALA, K; KASANEN, A; RAUSSI, M | 1 |
| MUDGE, GH; WEINER, IM | 1 |
| FARAH, A; FRAZER, M | 1 |
| BLANCHARD, KC; MUDGE, GH; WEINER, IM | 1 |
| HUANG, KC; LIN, DS | 1 |
| KUNIN, CM | 1 |
| Cox, S; Evans, AM; Nation, RL; Wang, J | 1 |
| Russel, FG; Smeets, PH; van Aubel, RA; van den Heuvel, JJ; Wouterse, AC | 1 |
| Chiba, M; Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Miyazaki, K; Shimamoto, S; Sugawara, M | 1 |
| Bahn, A; Braun, IM; Burckhardt, G; Hagos, Y; Krick, W | 1 |
| Ahmad, S; Zalups, RK | 3 |
| Braun, EJ; Dudas, PL; Pelis, RM; Renfro, JL | 1 |
| Schnabolk, GW; Sweet, DH; Youngblood, GL | 1 |
| Allen, CV; Groothuis, DR; Hertzler, S; Itskovich, AC; Kang, EW; Lipton, HL; Schlageter, KE; Vavra, MW | 1 |
| Hayashi, T; Kobayashi, Y; Kohyama, N; Ohbayashi, M; Tsuchiya, A; Yamamoto, T | 1 |
| Bridges, CC; Campos, I; Costa, F; Gonçalves, P; Keating, E; Lemos, C; Martel, F; Smith, SB | 1 |
| Adachi, M; Adachi, Y; Hu, Z; Kamiyama, E; Kondo, T; Kusuhara, H; Maeda, K; Nakazawa, H; Okano, T; Schuetz, JD; Shiroyanagi, Y; Sugiyama, D; Sugiyama, Y; Yamada, A | 1 |
| Abe, F; Hasegawa, T; Kato, M; Kimura, M; Kurono, S; Nadai, M; Saito, H; Yoshizumi, H | 1 |
| Mitsuoka, K; Nakakariya, M; Nakanishi, T; Shima, Y; Shirasaka, Y; Tamai, I | 1 |
| Arlt, VM; Bahn, A; Bakhiya, N; Burckhardt, G; Glatt, H; Phillips, DH | 1 |
| Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Endo, T; Hayasaka, M; Kimura, O; Tsukagoshi, K | 1 |
| Halberg, KA; Møbjerg, N | 1 |
| Fujibayashi, Y; Inubushi, M; Ito, S; Kusuhara, H; Oyama, N; Saga, T; Seki, C; Sugiyama, Y; Takahara, N; Yokoyama, O | 1 |
| Fujita, T; Horita, S; Ikeda, Y; Kondo, T; Kumagai, Y; Kusuhara, H; Maeda, K; Nakayama, H; Sugiyama, Y; Tanabe, K; Tian, Y | 1 |
| Hamada, Y; Ikemura, K; Iwamoto, T; Okuda, M | 1 |
| Chong, YM; Kaur, G; Tan, ML | 1 |
6 review(s) available for probenecid and p-aminohippuric acid
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Urate transport in the nephron.
Topics: Animals; Biological Transport, Active; Glucose; Humans; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Mersalyl; p-Aminohippuric Acid; Permeability; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Urate transport in the proximal tubule: in vivo and vesicle studies.
Topics: Absorption; Animals; Basement Membrane; Bicarbonates; Biological Transport, Active; Chlorides; Dogs; Humans; Hydroxides; Hydroxyl Radical; Infant, Newborn; Isomerism; Kidney Tubules, Proximal; Lactates; Lactic Acid; Microvilli; Models, Biological; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Species Specificity; Uric Acid | 1985 |
Renal organic anion transport system: pharmacological, physiological, and biochemical aspects.
Topics: Absorption; Animals; Anions; Anti-Bacterial Agents; Biological Transport; Diuretics; Humans; In Vitro Techniques; Kidney; Kidney Tubules; Ouabain; p-Aminohippuric Acid; Perfusion; Phenolsulfonphthalein; Phenylbutazone; Potassium; Probenecid; Sodium; Species Specificity; Substrate Specificity; Uric Acid | 1982 |
RENAL TUBULAR MECHANISMS FOR EXCRETION OF ORGANIC ACIDS AND BASES.
Topics: Acids; Biological Transport; Humans; Kidney; Kidney Tubules; p-Aminohippuric Acid; Pharmacology; Physiology; Probenecid; Uric Acid; Urine | 1964 |
4 trial(s) available for probenecid and p-aminohippuric acid
| Article | Year |
|---|---|
[The uricosuric effect of benzbromaron and probenecid under fasting conditions (author's transl)].
Topics: Benzbromarone; Benzofurans; Dose-Response Relationship, Drug; Fasting; Female; Humans; Kidney Tubules; Male; p-Aminohippuric Acid; Probenecid; Uric Acid | 1978 |
The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies.
Topics: Acetamides; Adolescent; Adult; Amoxicillin; Animals; Antiviral Agents; Biological Transport; CHO Cells; Cimetidine; Cricetinae; Cross-Over Studies; Drug Interactions; Female; Humans; Influenza, Human; Kidney; Male; Middle Aged; Neuraminidase; Organic Anion Transport Protein 1; Oseltamivir; p-Aminohippuric Acid; Probenecid; Prodrugs | 2002 |
Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug devel
Topics: Adult; Biological Transport; Cross-Over Studies; Drug Discovery; Glomerular Filtration Rate; Healthy Volunteers; Humans; Kidney; Kidney Function Tests; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Protein Binding; Technetium Tc 99m Mertiatide; Young Adult | 2013 |
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.
Topics: Adenine; Adult; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; p-Aminohippuric Acid; Penicillin G; Probenecid; Young Adult | 2014 |
182 other study(ies) available for probenecid and p-aminohippuric acid
| Article | Year |
|---|---|
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; COS Cells; Glycosylation; Histidine; In Situ Hybridization; Kidney; Kinetics; Mice; p-Aminohippuric Acid; Probenecid; Protein Processing, Post-Translational; Renal Agents; Substrate Specificity; Tunicamycin | 1999 |
Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; DNA, Complementary; HeLa Cells; Humans; Kidney; Molecular Sequence Data; p-Aminohippuric Acid; Protein Kinase C; Rats; Substrate Specificity; Tissue Distribution | 1999 |
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Blotting, Northern; Carrier Proteins; Chromosomes, Human, Pair 11; Cloning, Molecular; Humans; Kidney; Mice; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Transport of ochratoxin A by renal multispecific organic anion transporter 1.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Cell Survival; Female; Kidney; Kidney Tubules, Proximal; Kinetics; Mice; Ochratoxins; Oocytes; p-Aminohippuric Acid; Piroxicam; Recombinant Proteins; Transfection; Xenopus laevis | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.
Topics: Animals; Anion Transport Proteins; Anticholesteremic Agents; Antigens, Polyomavirus Transforming; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cell Line; Cell Survival; Cephaloridine; Cephalosporins; DNA, Complementary; Kidney Diseases; Kidney Tubules, Proximal; Lipid Peroxidation; Mice; Mice, Transgenic; Mutagenesis; p-Aminohippuric Acid; Probenecid; Probucol; Uricosuric Agents | 1999 |
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.
Topics: Animals; Anion Transport Proteins; Anions; Arylsulfonates; Boron Compounds; Carrier Proteins; CHO Cells; Cricetinae; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescein; Fluoresceins; Fluorescent Dyes; Glutarates; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Spectrometry, Fluorescence; Time Factors; Transfection | 2000 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.
Topics: Animals; Anion Transport Proteins; Blood-Brain Barrier; Brain; Carrier Proteins; Digoxin; Enzyme Inhibitors; Estradiol; Glucuronates; Male; Microinjections; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Taurocholic Acid | 2001 |
Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.
Topics: Animals; Anions; Carrier Proteins; Cations; Cell Line; Cell Membrane; Choline; Cloning, Molecular; Female; Guanidine; Histamine; Humans; In Vitro Techniques; Kidney; Kinetics; Membrane Potentials; Membrane Proteins; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Patch-Clamp Techniques; Quinine; Rats; Recombinant Proteins; Tetraethylammonium; Transfection; Xenopus laevis | 2001 |
Characterization of ochratoxin A transport by human organic anion transporters.
Topics: Animals; Biological Transport; Cell Line; Humans; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Potassium | 2001 |
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
Topics: Animals; Choroid Plexus; Cimetidine; Enzyme Inhibitors; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Penicillins; Rats; Rats, Sprague-Dawley | 2002 |
Role of human organic anion transporter 4 in the transport of ochratoxin A.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Humans; Immunohistochemistry; Kidney; Liver-Specific Organic Anion Transporter 1; Mice; Ochratoxins; Organic Anion Transporters, Sodium-Independent; Piroxicam; Probenecid; Recombinant Proteins; Transfection | 2002 |
Urate transport via human PAH transporter hOAT1 and its gene structure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Carbon Radioisotopes; Cell Line; Cloning, Molecular; Exons; Female; Gene Library; Gout; Humans; Kidney; Kidney Diseases; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Protein Structure, Tertiary; Pyrazinamide; Sodium Salicylate; Uric Acid; Uricosuric Agents | 2003 |
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.
Topics: Animals; Blood-Brain Barrier; Cimetidine; Convulsants; Endothelium, Vascular; Enzyme Inhibitors; Homovanillic Acid; Indican; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Rats; Rats, Wistar; Transfection; Tritium; Xenopus laevis | 2003 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
Topics: Binding Sites; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Static Electricity; Substrate Specificity | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee.
Topics: Animals; Diuresis; Drug Interactions; Ethacrynic Acid; Furosemide; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Male; Mersalyl; p-Aminohippuric Acid; Pan troglodytes; Potassium; Probenecid; Rats; Sodium Chloride; Stimulation, Chemical; Time Factors; Uric Acid; Uricosuric Agents | 1977 |
Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee.
Topics: Acetazolamide; Animals; Diuresis; Drug Interactions; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Kidney; Male; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Sodium Chloride; Time Factors; Uric Acid; Uricosuric Agents | 1977 |
Effect of hydrocarbon chain length on renal transport of monosubstituted sulfamyl benzoic acid derivatives and probenecid.
Topics: Animals; Benzoates; Biological Transport; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Rabbits; Structure-Activity Relationship; Time Factors | 1979 |
On the mechanism of p-piperidyl and p-benzyl sulfamyl benzoic acids transport by renal tissue.
Topics: Biological Transport; Caprylates; Chemical Phenomena; Chemistry; Humans; Kidney Cortex; Liposomes; p-Aminohippuric Acid; Phenolsulfonphthalein; Phosphatidylcholines; Probenecid; Protein Binding; Serum Albumin; Structure-Activity Relationship; Succinates | 1978 |
The transport of para-aminohippuric acid by the ciliary body and by the iris of the primate eye.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Ciliary Body; Cyanides; Dinitrophenols; Haplorhini; Iodopyracet; Iris; Macaca mulatta; Ouabain; p-Aminohippuric Acid; Probenecid | 1979 |
Urate excretion: drug interactions.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Glomerular Filtration Rate; Haplorhini; Male; Models, Biological; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Salicylates; Ultrafiltration; Uric Acid; Uricosuric Agents | 1979 |
Use of the tissue slice technique for evaluation of renal transport processes.
Topics: Acetates; Animals; Cats; Chlorides; Diatrizoate; Fishes; Galactose; Glucose; Humans; In Vitro Techniques; Iopanoic Acid; Kidney Cortex; Lactates; Methods; Niacinamide; p-Aminohippuric Acid; Potassium; Probenecid; Rabbits; Rats; Sodium; Succinates; Sulfates; Tetraethylammonium Compounds | 1976 |
The natural history of urate overproduction in sickle cell anemia.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Female; Humans; Male; Middle Aged; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Hepatic and biliary transport of orotate and its metabolic consequences.
Topics: Animals; Bile; Biological Transport, Active; In Vitro Techniques; Liver; Male; Orotic Acid; p-Aminohippuric Acid; Probenecid; Rats; Ribonucleosides; Tissue Distribution | 1979 |
Role of sodium ions in p-aminohippurate transport by newt kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Kidney; Kidney Tubules; Kinetics; Membrane Potentials; p-Aminohippuric Acid; Probenecid; Salamandridae; Sodium | 1979 |
Reduction of the renal toxicity of cis-dichlorodiammineplatinum(II) by probenecid.
Topics: Animals; Blood Urea Nitrogen; Cephaloridine; Cisplatin; Creatinine; Depression, Chemical; Kidney; Male; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred F344 | 1979 |
Transport and metabolism of octanoate by the perfused rat kidney.
Topics: Animals; Biological Transport; Caprylates; In Vitro Techniques; Kidney; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Rats | 1979 |
Secretion of prostaglandin E2 by rabbit proximal tubules.
Topics: Animals; Biological Transport, Active; Female; Indomethacin; Kidney Tubules, Proximal; Ouabain; p-Aminohippuric Acid; Probenecid; Prostaglandins E; Rabbits | 1979 |
Handling of oxalate by the rat kidney.
Topics: Animals; Biological Transport; Inulin; Kidney; Kidney Tubules, Proximal; Male; Oxalates; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats | 1978 |
The metabolism and active excretion of the hypoxanthine by the renal tubules in the chicken.
Topics: Allopurinol; Animals; Chickens; Female; Hypoxanthines; Kidney; Kidney Tubules; Oxypurinol; p-Aminohippuric Acid; Probenecid; Quinine | 1978 |
Renal handling of oxalate. A micropuncture study in the rat.
Topics: Animals; Glomerular Filtration Rate; Inulin; Kidney; Kidney Tubules; Male; Oxalates; p-Aminohippuric Acid; Probenecid; Rats | 1978 |
Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages.
Topics: Aging; Aminohippuric Acids; Animals; Animals, Newborn; Cycloheximide; Cyclopenthiazide; Female; Kidney Cortex; Male; p-Aminohippuric Acid; Phenolsulfonphthalein; Probenecid; Rats; Stimulation, Chemical; Sulfamethoxypyridazine; Tromethamine | 1978 |
Organic acid secretory pathway and urinary excretion of prostaglandin E in the dog.
Topics: Animals; Diuresis; Dogs; Female; Glomerular Filtration Rate; Indomethacin; Kidney; Male; p-Aminohippuric Acid; Probenecid; Prostaglandins E | 1978 |
Kinetics studies on the renal transport of probenecid in vitro.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Bromcresol Green; Bromphenol Blue; Female; Kidney Tubules; Kinetics; Male; p-Aminohippuric Acid; Phenolsulfonphthalein; Probenecid; Rabbits | 1978 |
A comparative study on the accumulation of probenecid and analogues in rabbit kidney tubules in vitro.
Topics: Animals; Binding, Competitive; Female; In Vitro Techniques; Kidney Tubules; Liposomes; Male; p-Aminohippuric Acid; Phenolsulfonphthalein; Probenecid; Protein Binding; Rabbits; Serum Albumin | 1979 |
Transport of 2,4,5-trichlorophenoxyacetate in the isolated, perfused rat kidney.
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Animals; Biological Transport; Dextrans; Kidney; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Protein Binding; Rats; Serum Albumin, Bovine; Tetraethylammonium Compounds | 1979 |
Transport of metabolic substrates through the blood-brain barrier.
Topics: Amino Acids; Animals; Biogenic Amines; Biological Transport; Blood-Brain Barrier; Carboxylic Acids; Choline; Electrolytes; Glucose; Hexoses; Hormones; Hydroxyindoleacetic Acid; Kinetics; Lactates; p-Aminohippuric Acid; Probenecid; Prostaglandins; Purine Nucleosides; Pyruvates; Vitamins | 1977 |
Inhibition of probenecid uricosuria by pyrazinamide and para-aminohippurate.
Topics: Adolescent; Adult; Aminohippuric Acids; Depression, Chemical; Humans; Male; Middle Aged; p-Aminohippuric Acid; Probenecid; Pyrazinamide; RNA; Uric Acid | 1977 |
Evidence for two secretory mechanisms for organic acid transport in man.
Topics: Biological Transport; Humans; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Movement of p-aminohippurate between lumen and cells of renal tubule.
Topics: Aminohippuric Acids; Animals; Biological Transport; Dose-Response Relationship, Drug; Inulin; Kidney Glomerulus; Kidney Tubules, Proximal; Kinetics; Male; p-Aminohippuric Acid; Probenecid; Rabbits | 1977 |
Characteristics of accumulation of probenecid by rabbit kidney cortical slices.
Topics: Acetates; Aerobiosis; Anaerobiosis; Animals; Binding Sites; Biological Transport, Active; Caprylates; Cell-Free System; Cyanides; Dinitrophenols; Female; In Vitro Techniques; Iodoacetamide; Kidney Cortex; Male; p-Aminohippuric Acid; Phenolsulfonphthalein; Phospholipids; Probenecid; Rabbits; Serum Albumin; Succinates | 1977 |
[Concentration of p-aminohippuric acid in the serum and kidney tissue during stimulation of renal excretion of foreign materials].
Topics: Aminohippuric Acids; Animals; Cyclopenthiazide; Half-Life; Kidney; p-Aminohippuric Acid; Phenobarbital; Probenecid; Rats | 1977 |
Comparison of renal and hepatic glutathione S-transferases in the rat.
Topics: Animals; Chromatography, Gel; Furosemide; Glutathione Transferase; Hypophysectomy; Kidney; Kinetics; Liver; Male; p-Aminohippuric Acid; Probenecid; Rats; Thyroxine | 1976 |
[Extent and duration of drug-induced stimulation of renal excretion of p-aminohippuric acid].
Topics: Aminohippuric Acids; Animals; Cyclopenthiazide; Female; Glomerular Filtration Rate; Kidney; p-Aminohippuric Acid; Phenobarbital; Premedication; Probenecid; Rats; Stimulation, Chemical; Time Factors | 1976 |
Effect of probenecid on tetraethyl ammonium (TEA) transport across basolateral membrane of rabbit proximal tubule.
Topics: Animals; Biological Transport; Cell Membrane; Female; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Proximal; Male; Oxygen Consumption; p-Aminohippuric Acid; Probenecid; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
p-Aminohippurate transport in airways: competitive inhibition.
Topics: Animals; Biological Transport; Cyclic AMP; Dogs; Electrophysiology; Epithelium; p-Aminohippuric Acid; Phenolsulfonphthalein; Probenecid; Trachea; Uric Acid | 1992 |
Sodium-sensitive, probenecid-insensitive p-aminohippuric acid uptake in cultured renal proximal tubule cells of the rabbit.
Topics: Alkaline Phosphatase; Animals; Biological Transport; Cells, Cultured; gamma-Glutamyltransferase; Kidney Tubules, Proximal; Methylglucosides; p-Aminohippuric Acid; Probenecid; Rabbits; Sodium | 1992 |
Urate excretion by the cat kidney.
Topics: Animals; Cats; Female; Kidney; Male; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Acute renal toxicity of thiabendazole (TBZ) in ICR mice.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Interactions; Kidney; Male; Mice; Mice, Inbred ICR; Organ Size; p-Aminohippuric Acid; Probenecid; Tetraethylammonium; Tetraethylammonium Compounds; Thiabendazole; Thiamine | 1992 |
Specificity of basolateral organic anion exchanger in proximal tubule for cellular and extracellular solutes.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Dicarboxylic Acids; Fatty Acids; Female; Fluorescein; Fluoresceins; Kidney Tubules, Proximal; Models, Biological; p-Aminohippuric Acid; Probenecid; Rabbits; Substrate Specificity | 1992 |
Contraluminal p-aminohippurate transport in the proximal tubule of the rat kidney. VII. Specificity: cyclic nucleotides, eicosanoids.
Topics: Animals; Biological Transport; Cyclic AMP; Cyclic GMP; Dicarboxylic Acids; Dinoprostone; Eicosanoids; Indomethacin; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Prostaglandin D2; Rats; Rats, Inbred Strains; Sulfates; Time Factors | 1991 |
Effects of cysteine derivatives of styrene on the transport of p-aminohippurate ion in renal plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cysteine; In Vitro Techniques; Kidney; Male; Microvilli; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Styrenes | 1991 |
Moment analysis of drug disposition in rat kidney: role of basolateral membrane transport in renal transepithelial transport of p-aminohippurate.
Topics: Animals; Biological Transport, Active; Blood Proteins; Epithelium; In Vitro Techniques; Kidney; Male; Membranes; p-Aminohippuric Acid; Pharmaceutical Preparations; Pharmacokinetics; Probenecid; Protein Binding; Rats; Rats, Inbred Strains | 1991 |
Urate transport in the proximal tubule of human kidney.
Topics: Biological Transport; Humans; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Lactates; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Influence of probenecid on P-amino hippurate kinetics.
Topics: Animals; Female; Injections, Intravenous; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains | 1991 |
Contraluminal p-aminohippurate transport in the proximal tubule of the rat kidney. VIII. Transport of corticosteroids.
Topics: Adrenal Cortex Hormones; Animals; Biological Transport; Dicarboxylic Acids; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Sulfates | 1991 |
Effect of S-(2-chloroethyl)-DL-cysteine on the transport of p-aminohippurate ion in renal plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cysteine; gamma-Glutamyltransferase; Kidney Cortex; Kinetics; Male; Microvilli; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred F344; Sodium-Potassium-Exchanging ATPase | 1990 |
Cadmium inhibition of basolateral solute fluxes in rabbit renal tubules and the nature of cycloleucine uptake.
Topics: Animals; Biological Transport; Cadmium; Cycloleucine; Kidney Cortex; Kidney Tubules; Leucine; Male; p-Aminohippuric Acid; Probenecid; Rabbits | 1991 |
Moment analysis of drug disposition in kidney. V: In vivo transepithelial transport of p-aminohippurate in rat kidney.
Topics: Animals; Blood Proteins; Epithelium; Injections, Intravenous; Inulin; Kidney; Male; Models, Biological; p-Aminohippuric Acid; Probenecid; Protein Binding; Rats; Rats, Inbred Strains; Urodynamics | 1991 |
Effect of substituted benzoates on p-aminohippurate transport in dog renal membrane vesicles.
Topics: Animals; Benzoates; Biological Transport; Dogs; Kidney; Kinetics; Membranes; Microvilli; p-Aminohippuric Acid; Probenecid; Structure-Activity Relationship | 1991 |
Permeability of the blood-ocular barrier to mannitol and PAH during experimental diabetes.
Topics: Analysis of Variance; Animals; Biological Transport, Active; Blood Volume; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Experimental; Hematocrit; Male; Mannitol; p-Aminohippuric Acid; Probenecid; Retina; Vitreous Body | 1990 |
Radiation target sizes of the Na,K-ATPase and p-aminohippurate transport system in the basolateral membrane of renal proximal tubule.
Topics: Aminohippuric Acids; Animals; Biological Transport; Biomarkers; Cell Membrane; Cell Membrane Permeability; Enzyme Activation; Glucose; Kidney Tubules, Proximal; p-Aminohippuric Acid; Probenecid; Protein Conformation; Rabbits; Reproducibility of Results; Sodium; Sodium-Potassium-Exchanging ATPase | 1990 |
In vivo evidence for carrier-mediated uptake of beta-lactam antibiotics through organic anion transport systems in rat kidney and liver.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Dose-Response Relationship, Drug; Kidney; Liver; Male; p-Aminohippuric Acid; Penicillin G; Probenecid; Rats; Rats, Inbred Strains | 1990 |
Effect of probenecid on the urinary excretion of TXB2 and PGE2 in the anaesthetised rat.
Topics: Animals; Blood Pressure; Dinoprostone; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Rats; Thromboxane B2; Urine | 1990 |
Organic anion secretion by winter flounder renal proximal tubule primary monolayer cultures.
Topics: Animals; Biological Transport; Cells, Cultured; Flounder; Glutarates; Kidney Tubules, Proximal; Kinetics; Ouabain; p-Aminohippuric Acid; Probenecid; Sodium | 1990 |
Transport of p-aminohippuric acid (3H-PAH), inulin and dextran out of the cranial cavity: a methodological study using intraventricular injection and sample combustion.
Topics: Aminohippuric Acids; Animals; Brain; Dextrans; Female; Injections, Intraventricular; Inulin; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains | 1987 |
Renal handling of 2-methyl-4-chlorophenoxyacetic acid (MCPA) in rats.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Animals; Blood Proteins; Diuresis; Female; Glycolates; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Protein Binding; Rats; Rats, Inbred Strains; Triiodothyronine | 1989 |
Mediated transport of long-chain fatty acids by rat renal basolateral membranes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Biological Transport; Cell Membrane; Hydrogen-Ion Concentration; Kidney; Kinetics; Male; Microvilli; p-Aminohippuric Acid; Palmitic Acid; Palmitic Acids; Probenecid; Rats; Rats, Inbred Strains; Sulfates; Valinomycin | 1989 |
N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism.
Topics: Acetylation; Aminooxyacetic Acid; Animals; Biological Transport; Cysteine; Dose-Response Relationship, Drug; Hydrocarbons, Halogenated; Kidney Cortex; Kidney Tubules, Proximal; p-Aminohippuric Acid; Potassium; Probenecid; Rabbits | 1989 |
Alloxan stimulates p-aminohippurate uptake in renal basal-lateral membranous vesicles.
Topics: Alloxan; Aminohippuric Acids; Animals; Basement Membrane; Ethylmaleimide; Glucose; Glutamates; Glutamic Acid; Hydrogen Peroxide; Kidney; Ninhydrin; p-Aminohippuric Acid; Probenecid; Rabbits; Time Factors | 1985 |
Lack of interaction between atrial natriuretic factor and renal organic anion transport system.
Topics: Aminohippuric Acids; Animals; Anions; Atrial Natriuretic Factor; Female; In Vitro Techniques; Kidney; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Tetraethylammonium | 1986 |
Mechanism of renal concentration of technetium-99m glucoheptonate.
Topics: Acid-Base Imbalance; Animals; Female; Iodine Radioisotopes; Iothalamic Acid; Kidney; Organotechnetium Compounds; p-Aminohippuric Acid; Probenecid; Radionuclide Imaging; Rats; Rats, Inbred Strains; Succimer; Sugar Acids; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid | 1985 |
Renal tubular transport of delta-aminolevulinic acid in rat.
Topics: Aminoisobutyric Acids; Aminolevulinic Acid; Animals; Autoradiography; Biological Transport; Cycloleucine; Female; Galactose; Glycine; Kidney Cortex; Kidney Tubules; Kinetics; Levulinic Acids; Lysine; Oxygen Consumption; p-Aminohippuric Acid; Potassium Cyanide; Probenecid; Proline; Rats; Rats, Inbred Strains | 1986 |
Indirect coupling to Na+ of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles.
Topics: Aminohippuric Acids; Animals; Basement Membrane; Glutarates; Kidney; Lithium; Mannitol; p-Aminohippuric Acid; Probenecid; Rats; Sodium | 1987 |
Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport.
Topics: Aminohippuric Acids; Animals; Binding, Competitive; Biological Transport, Active; Furosemide; In Vitro Techniques; Kidney; Membranes; p-Aminohippuric Acid; Probenecid; Rabbits; Sulfisoxazole | 1988 |
Tubular mechanisms determining the urinary excretion of tritiated prostaglandin E2 in the anaesthetized rat.
Topics: Animals; Biological Transport; Dinoprostone; Inulin; Kidney; Kidney Tubules; Male; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Tritium | 1988 |
Probenecid infusion in mares: effect on para-aminohippuric acid clearance.
Topics: Administration, Oral; Aminohippuric Acids; Animals; Biological Availability; Female; Horses; Infusions, Intravenous; Mathematics; p-Aminohippuric Acid; Probenecid; Software | 1988 |
Indomethacin secretion in the isolated perfused proximal straight rabbit tubule. Evidence for two parallel transport mechanisms.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Biological Transport, Active; Indomethacin; Kidney Tubules, Proximal; Kinetics; Organ Culture Techniques; p-Aminohippuric Acid; Probenecid; Rabbits; Sodium; Temperature | 1988 |
Complexing activity and excretion of 2,3-dimercapto-1-propane sulfonate in rat kidney.
Topics: Animals; Carbon Radioisotopes; Dimercaprol; Diuresis; In Vitro Techniques; Kidney; Kidney Tubules; Kinetics; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Rats; Renal Circulation; Unithiol | 1988 |
Na+ and H+ gradient-dependent transport of p-aminohippurate in membrane vesicles from dog kidney cortex.
Topics: Aminohippuric Acids; Animals; Anions; Biological Transport, Active; Dogs; Glucose; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Cortex; Kinetics; Membrane Potentials; Microvilli; p-Aminohippuric Acid; Probenecid; Sodium; Valinomycin | 1988 |
Preparation of basolateral membranes that transport p-aminohippurate from primary cultures of rabbit kidney proximal tubule cells.
Topics: Aminohippuric Acids; Animals; Basement Membrane; Cells, Cultured; Glucose; Kidney Tubules, Proximal; p-Aminohippuric Acid; Probenecid; Rabbits | 1988 |
Excretion of para-aminohippurate in the isolated perfused rat kidney: net secretion and net reabsorption.
Topics: Absorption; Alanine; Aminohippuric Acids; Animals; Biological Transport; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Kidney Tubules; p-Aminohippuric Acid; Perfusion; Probenecid; Rats; Rats, Inbred Strains | 1988 |
Superiority of tetraethylammonium to p-aminohippurate as a marker for renal plasma flow during furosemide diuresis.
Topics: Aminohippuric Acids; Animals; Anions; Diuresis; Female; Furosemide; Kidney; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Renal Circulation; Tetraethylammonium Compounds | 1987 |
Transport of prostaglandins and other eicosanoids by the choroid plexus: its characterization and physiological significance.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Biological Transport, Active; Cats; Choroid Plexus; Dinoprost; Dinoprostone; Dogfish; Eicosanoic Acids; Epoprostenol; Kinetics; p-Aminohippuric Acid; Probenecid; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits; Substrate Specificity; Thromboxane B2 | 1986 |
In vivo renal tubular secretion of trimethoprim without metabolism.
Topics: Animals; Biological Transport, Active; Chickens; Female; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Tetraethylammonium Compounds; Trimethoprim | 1987 |
Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit.
Topics: Aminohippuric Acids; Animals; Biological Transport; Female; Furosemide; Glomerular Filtration Rate; In Vitro Techniques; Indomethacin; Kidney; Male; Natriuresis; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rabbits; Time Factors; Tritium | 1986 |
Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake.
Topics: Amino Acids; Animals; Anions; Cattle; Cephalosporins; In Vitro Techniques; Kinetics; Liver; Male; p-Aminohippuric Acid; Penicillin G; Peptides; Probenecid; Rats; Rats, Inbred Strains; Serum Albumin; Serum Albumin, Bovine; Sodium; Taurocholic Acid | 1986 |
Dependence of proximal tubule p-aminohippurate secretion on serum proteins and metabolic substrates.
Topics: Aminohippuric Acids; Animals; Blood Proteins; Female; In Vitro Techniques; Kidney Tubules, Proximal; Osmolar Concentration; p-Aminohippuric Acid; Perfusion; Probenecid; Rabbits | 1986 |
Evidence for a secretory component in the handling of unconjugated bilirubin by the isolated perfused rat kidney.
Topics: Animals; Bilirubin; In Vitro Techniques; Kidney; Kinetics; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1985 |
Characteristics of renal p-aminohippurate and urate excretion in rabbits.
Topics: Aminohippuric Acids; Animals; Blood Proteins; Female; Kidney; Kinetics; p-Aminohippuric Acid; Probenecid; Protein Binding; Rabbits; Uric Acid | 1986 |
The renal handling of terephthalic acid.
Topics: Animals; Carbon Radioisotopes; Chickens; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Humans; In Vitro Techniques; Infusions, Parenteral; Kidney; Male; p-Aminohippuric Acid; Phthalic Acids; Probenecid; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Uric Acid | 1985 |
Renal tubular excretory transport of oxalate in the chicken.
Topics: Animals; Biological Transport; Chickens; Dicarboxylic Acids; Kidney Tubules; Oxalates; p-Aminohippuric Acid; Phthalic Acids; Probenecid; Uric Acid | 1985 |
Renal transport of gossypol in the rabbit.
Topics: 2,4-Dinitrophenol; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Binding, Competitive; Biological Transport; Biological Transport, Active; Dinitrophenols; Gossypol; In Vitro Techniques; Iodoacetamide; Kidney Cortex; Kinetics; Nitrogen; Ouabain; p-Aminohippuric Acid; Probenecid; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds | 1985 |
Secretion of p-aminohippurate by the rat epididymis.
Topics: Aminohippuric Acids; Animals; Castration; Epididymis; Kinetics; Male; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Secretory Rate | 1985 |
Mechanism of renal excretion of FK027 in dogs and rabbits.
Topics: Absorption; Animals; Cefixime; Cefotaxime; Dogs; Kidney; Male; Metabolic Clearance Rate; p-Aminohippuric Acid; Probenecid; Rabbits; Species Specificity | 1985 |
Uptake of trimethoprim by renal cortex.
Topics: Animals; Biological Transport, Active; Cold Temperature; Dinitrophenols; Energy Metabolism; Female; Kidney Cortex; Kinetics; Male; Nitrogen; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Trimethoprim; Tritium | 1985 |
Urate and p-aminohippurate transport in rat renal basolateral vesicles.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Chlorides; Ion Exchange; Kidney; Lactates; Membranes; p-Aminohippuric Acid; Potassium; Probenecid; Rats; Rats, Inbred Strains; Sodium; Uric Acid | 1985 |
Effects of the diuretic torasemide on p-aminohippuric acid transport in the rat.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Diuretics; Furosemide; Glomerular Filtration Rate; Inulin; Kidney Tubules; Male; Microinjections; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Sulfonamides; Torsemide | 1985 |
Renal disposition of moxalactam in experimental animals as revealed by stop-flow analysis.
Topics: Animals; Anti-Bacterial Agents; Blood Proteins; Cephalosporins; Cephamycins; Dogs; Kidney; Macaca fascicularis; Male; Metabolic Clearance Rate; Moxalactam; p-Aminohippuric Acid; Probenecid; Protein Binding; Rabbits; Species Specificity | 1983 |
Choline and PAH transport across blood-CSF barriers: the effect of lithium.
Topics: Aminohippuric Acids; Animals; Arachnoid; Blood-Brain Barrier; Chlorides; Choline; Choroid Plexus; Lithium; Lithium Chloride; Ouabain; p-Aminohippuric Acid; Probenecid; Rana catesbeiana | 1982 |
Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Cell Membrane; Furosemide; Hydrogen-Ion Concentration; Kidney Cortex; Kinetics; Microvilli; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Tritium; Uric Acid | 1983 |
Mechanisms for the renal secretion of cisplatin.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Cimetidine; Cisplatin; In Vitro Techniques; Kidney; Male; Mice; Mice, Inbred AKR; p-Aminohippuric Acid; Platinum; Probenecid; Tetraethylammonium; Tetraethylammonium Compounds | 1984 |
Effects of analogs of salicylate on p-aminohippurate uptake into basal-lateral membranous vesicles.
Topics: Aminohippuric Acids; Animals; Basement Membrane; Benzoates; Biological Transport, Active; Kidney Cortex; Mersalyl; Organomercury Compounds; p-Aminohippuric Acid; Probenecid; Rabbits; Salicylates; Salicylic Acid; Sulfhydryl Compounds; Thimerosal | 1984 |
Effects of trypsin and protein modification on the renal transporter of p-aminohippurate.
Topics: Amino Acid Transport Systems; Aminohippuric Acids; Animals; Biological Transport; Cell Membrane; Glucose; Kidney Cortex; Membrane Proteins; Membrane Transport Proteins; Molecular Weight; p-Aminohippuric Acid; Probenecid; Rabbits; Trypsin | 1984 |
Urate transport via anion exchange in dog renal microvillus membrane vesicles.
Topics: Animals; Biological Transport; Chlorides; Dogs; Glucose; Hydrogen-Ion Concentration; Ion Exchange; Kidney Cortex; Microvilli; p-Aminohippuric Acid; Potassium; Probenecid; Uric Acid; Valinomycin | 1983 |
[Inhibition of the renal excretion of PAH by probenecid homologs].
Topics: Aminohippuric Acids; Animals; Chemical Phenomena; Chemistry, Physical; Dose-Response Relationship, Drug; Female; Lethal Dose 50; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Competitive inhibition of methotrexate accumulation in rabbit kidney slices by nonsteroidal anti-inflammatory drugs.
Topics: 2,4-Dinitrophenol; Animals; Anti-Inflammatory Agents; Aspirin; Binding, Competitive; Dinitrophenols; Kidney Cortex; Kinetics; Methotrexate; Nitrogen; p-Aminohippuric Acid; Probenecid; Rabbits | 1983 |
Effects of divalent cations and sulfhydryl reagents on the p-aminohippurate (PAH) transporter of renal basal-lateral membranes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Cations, Divalent; Cell Membrane; Iodobenzoates; Kidney Cortex; Magnesium; Mersalyl; Organomercury Compounds; p-Aminohippuric Acid; Probenecid; Rabbits; Salicylates; Sulfhydryl Reagents | 1983 |
Accumulation of cimetidine by kidney cortex slices.
Topics: Animals; Cimetidine; Dogs; Energy Metabolism; Guanidines; In Vitro Techniques; Kidney Cortex; Male; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Sodium Cyanide; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1982 |
A case of familial renal hypouricemia associated with increased secretion of para-aminohippurate and idiopathic edema.
Topics: Adult; Aged; Aminohippuric Acids; Edema; Female; Humans; Kidney Function Tests; Male; p-Aminohippuric Acid; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Saline Solution, Hypertonic; Ticrynafen; Uric Acid | 1982 |
Long chain fatty acid transport by the perfused rat kidney.
Topics: Animals; Kidney Tubules; Male; p-Aminohippuric Acid; Palmitates; Palmitic Acids; Probenecid; Rats | 1982 |
The effect of probenecid on citrinin-induced nephrotoxicity.
Topics: Animals; Benzopyrans; Chromatography, High Pressure Liquid; Citrinin; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Diseases; Male; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains | 1982 |
Mechanisms of p-aminohippurate transport by brush-border and basolateral membrane vesicles isolated from rat kidney cortex.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport, Active; Cell Membrane; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Membrane Potentials; Microvilli; p-Aminohippuric Acid; Probenecid; Rats; Rats, Inbred Strains | 1982 |
Bidirectional active transport of thiosulfate in the proximal convolution of the rat kidney.
Topics: Animals; Benzoates; Biological Transport, Active; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Rats; Sulfonamides; Thiosulfates | 1980 |
Oxalate secretion in the rat proximal tubule.
Topics: Animals; Biological Transport, Active; Chloromercuribenzoates; Dose-Response Relationship, Drug; Furosemide; Kidney Tubules, Proximal; Male; Oxalates; p-Aminohippuric Acid; Probenecid; Rats; Sodium Cyanide | 1981 |
Basis for heterogeneity of para-aminohippurate secretion in rabbit proximal tubules.
Topics: Aminohippuric Acids; Animals; Biological Transport; Female; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Models, Biological; p-Aminohippuric Acid; Probenecid; Rabbits | 1981 |
[Stimulation of the renal excretion of p-aminohippuric acid by probenecid homologues (author's transl)].
Topics: Aminohippuric Acids; Humans; Lethal Dose 50; p-Aminohippuric Acid; Probenecid; Stimulation, Chemical; Time Factors | 1981 |
Uptake of [3H]PAH and [14C]urate into isolated proximal tubular segments of the pig kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Swine; Uric Acid | 1981 |
Peritubular uptake of lactate by Thamnophis proximal tubule.
Topics: Animals; Biological Transport, Active; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Lactates; p-Aminohippuric Acid; Probenecid; Snakes | 1980 |
Accumulation of [14C]urate and [3H]PAH in isolated proximal tubular segments of the rabbit kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Female; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Pyrazinamide; Rabbits; Tritium; Uric Acid | 1980 |
Mechanism of renal tubular secretion of norepinephrine in the rabbit.
Topics: Animals; Carbon Radioisotopes; Kidney Tubules; Male; Norepinephrine; p-Aminohippuric Acid; Probenecid; Rabbits; Tetraethylammonium Compounds; Tritium | 1980 |
Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
Topics: Acetylcysteine; Animals; Anion Transport Proteins; Carrier Proteins; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Mercuric Chloride; p-Aminohippuric Acid; Probenecid; Rabbits | 1995 |
Characterization of fluorescein transport in isolated proximal tubular cells of the rat: evidence for mitochondrial accumulation.
Topics: Animals; Biological Transport; Fluorescein; Fluoresceins; Kidney Tubules, Proximal; Male; Mitochondria; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar | 1994 |
Urate transport in brush-border membrane of human kidney.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Biological Transport; Carbon Radioisotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Humans; Hydroxybutyrates; Kidney Cortex; Kidney Neoplasms; Kinetics; Lactates; Microvilli; Middle Aged; p-Aminohippuric Acid; Probenecid; Uric Acid; Valinomycin | 1994 |
Characterization of p-aminohippurate transport from rat kidney which is expressed after injection of size-selected mRNA into oocytes of Xenopus laevis.
Topics: Animals; Biological Transport; Carrier Proteins; Female; Gene Expression; Kidney Cortex; Oocytes; p-Aminohippuric Acid; Particle Size; Probenecid; Rats; RNA, Messenger; Sodium; Transfection; Xenopus laevis | 1993 |
p-Aminohippurate/2-oxoglutarate exchange in bovine renal brush-border and basolateral membrane vesicles.
Topics: Animals; Biological Transport; Cattle; Cell Membrane; Ketoglutaric Acids; Kidney Tubules, Proximal; Kinetics; Liposomes; Microvilli; p-Aminohippuric Acid; Probenecid; Sodium | 1993 |
Tissue concentration and urinary excretion pattern of sulfofluorescein by the rat kidney.
Topics: Animals; Biological Transport, Active; Blood Proteins; Dicarboxylic Acids; Fluoresceins; Kidney; Kinetics; Male; p-Aminohippuric Acid; Probenecid; Protein Binding; Rats; Rats, Wistar; Tissue Distribution | 1993 |
Basolateral glutarate transport by isolated S2 segments of rabbit kidney proximal tubules.
Topics: Animals; Biological Transport; Glutarates; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Rabbits | 1996 |
Plasma clearance in the rat of a furan dicarboxylic acid which accumulates in uremia.
Topics: Animals; Female; Furans; Infusions, Intravenous; p-Aminohippuric Acid; Probenecid; Propionates; Rats; Rats, Wistar; Renal Agents; Uremia | 1996 |
Renal transepithelial secretion of ochratoxin A in the non-filtering toad kidney.
Topics: Animals; Epithelial Cells; Epithelium; Ketoglutaric Acids; Kidney; Kidney Tubules, Proximal; Mycotoxins; Ochratoxins; p-Aminohippuric Acid; Perfusion; Phenylalanine; Probenecid; Protein Binding; Serum Albumin, Bovine; Substrate Specificity; Uricosuric Agents; Xenopus laevis | 1997 |
Restricted intestinal absorption of some beta-lactam antibiotics by an energy-dependent efflux system in rat intestine.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Energy Metabolism; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; p-Aminohippuric Acid; Probenecid; Rats; Spectrophotometry, Ultraviolet; Uricosuric Agents; Verapamil | 1997 |
Inhibition of the conjugation of PABA with glycine in vitro by sulfamoyl benzoic acids, sulfonamides, and penicillins and its relation to tubular secretion.
Topics: 4-Aminobenzoic Acid; Animals; Chromatography, High Pressure Liquid; Female; Glycine; In Vitro Techniques; Kidney Tubules; Microsomes, Liver; Neural Networks, Computer; p-Aminohippuric Acid; Penicillins; Probenecid; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfonamides | 1998 |
Efflux of intracellular alpha-ketoglutarate via p-aminohippurate/dicarboxylate exchange in OK kidney epithelial cells.
Topics: Antimycin A; Cells, Cultured; Epithelial Cells; Ketoglutaric Acids; Kidney; p-Aminohippuric Acid; Probenecid; Sodium | 1998 |
Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney.
Topics: Animals; Anion Transport Proteins; Anions; Biological Transport; Carrier Proteins; Cell Membrane; Dicarboxylic Acids; Diterpenes; DNA Primers; DNA, Complementary; Female; Folic Acid; Glutarates; Kidney; Kinetics; Methotrexate; Oocytes; p-Aminohippuric Acid; Phorbol Esters; Probenecid; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Xenopus laevis | 1998 |
Effects of inhibitors and substitutes for chloride in lumen on p-aminohippurate transport by isolated perfused rabbit renal proximal tubules.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Biological Transport; Cell Membrane Permeability; Chlorides; In Vitro Techniques; Kidney Tubules, Proximal; p-Aminohippuric Acid; Perfusion; Permeability; Probenecid; Rabbits; Sulfuric Acid Esters; Time Factors | 1999 |
Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Enzyme Inhibitors; Fluorescent Dyes; In Vitro Techniques; Inulin; Isoquinolines; Kidney Tubules, Proximal; Killifishes; Leukotriene C4; Male; Microscopy, Confocal; Ouabain; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Renal Agents; Sodium | 1999 |
Transport of [3H]losartan across isolated perfused rabbit proximal tubule.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; In Vitro Techniques; Ketoglutaric Acids; Kidney Tubules, Proximal; Losartan; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Rabbits; Renal Agents | 1999 |
Demonstration of a probenecid-inhibitable anion exchanger involved in the release of cortisol and cAMP and in the uptake of p-aminohippurate in bovine adrenocortical cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Antiporters; Biological Transport; Cattle; Cells, Cultured; Culture Media; Cyclic AMP; Glutarates; Hydrocortisone; Kinetics; p-Aminohippuric Acid; Probenecid; Tritium | 1999 |
Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT).
Topics: Animals; Anion Transport Proteins; Biological Transport, Active; Bumetanide; Carrier Proteins; Cells, Cultured; Clone Cells; Dicarboxylic Acid Transporters; Diuretics; Dose-Response Relationship, Drug; Escherichia coli Proteins; Flounder; Furosemide; Kidney Tubules, Proximal; Membrane Potentials; Membrane Transport Proteins; Oocytes; p-Aminohippuric Acid; Patch-Clamp Techniques; Probenecid; Substrate Specificity; Xenopus laevis | 2000 |
Novel aspects of the transport of organic anions by the malpighian tubules of Drosophila melanogaster.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carboxylic Acids; Carrier Proteins; Cyclic AMP; Diffusion; Drosophila melanogaster; Female; Ion Transport; Kinetics; Malpighian Tubules; Membrane Potentials; Microscopy, Confocal; Microscopy, Fluorescence; Ouabain; p-Aminohippuric Acid; Phosphotransferases; Probenecid; Second Messenger Systems; Sodium; Sodium-Potassium-Exchanging ATPase | 2000 |
Riboflavin transport by isolated perfused rabbit renal proximal tubules.
Topics: Animals; Antipsychotic Agents; Biological Transport; Calcium; Calmodulin; Carcinogens; Chlorpromazine; Cyclic AMP; Dose-Response Relationship, Drug; Flavins; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Phorbol Esters; Probenecid; Rabbits; Riboflavin; Temperature; Trifluoperazine; Uricosuric Agents | 2000 |
Secretory transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue.
Topics: Animals; Biological Transport; Caco-2 Cells; Cell Membrane; Digestive System; Enzyme Inhibitors; Epithelium; Genistein; Humans; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Uricosuric Agents | 2001 |
The distribution of the anti-HIV drug, 2'3'-dideoxycytidine (ddC), across the blood-brain and blood-cerebrospinal fluid barriers and the influence of organic anion transport inhibitors.
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anti-HIV Agents; Blood-Brain Barrier; Capillaries; Carbon Radioisotopes; Choroid Plexus; Chromatography, High Pressure Liquid; Diuretics, Osmotic; Guinea Pigs; Herbicides; Mannitol; Octanols; Oligopeptides; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Perfusion; Probenecid; Sodium Chloride; Tritium; Uricosuric Agents; Zalcitabine; Zidovudine | 2002 |
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Topics: Animals; Anions; Biological Transport; Dose-Response Relationship, Drug; Female; Furans; Indican; Kidney; Kidney Failure, Chronic; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Propionates; Rats; Rats, Wistar; Toxins, Biological; Tritium; Uremia; Uricosuric Agents; Xenopus laevis | 2002 |
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.
Topics: Animals; Anions; Biological Transport; Blotting, Northern; Brain; Cerebrospinal Fluid; Choroid Plexus; Cloning, Molecular; Estrone; Kidney; Liver; Mice; Mice, Knockout; Microscopy, Confocal; Models, Genetic; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Phenotype; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfobromophthalein; Taurocholic Acid; Xenopus | 2002 |
Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient.
Topics: Animals; Dicarboxylic Acids; Estrone; Glutarates; In Vitro Techniques; Ion Transport; Lithium; Microinjections; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Rats; Sodium; Taurocholic Acid; Xenopus laevis | 2003 |
p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chlorides; Epithelial Cells; Hydrogen-Ion Concentration; Kidney; Opossums; p-Aminohippuric Acid; Probenecid | 2002 |
[Effect of benemid on p-aminohippuric acid blood level].
Topics: Humans; p-Aminohippuric Acid; Probenecid | 1953 |
Contrasting inhibitory effects of probenecid on the renal tubular excretion of p-aminohippurate and on the active reabsorption of urea in the dogfish, Squalus acanthias.
Topics: Animals; Biological Transport; Dogfish; Kidney; p-Aminohippuric Acid; Probenecid; Squalus acanthias; Urea | 1957 |
Effect of some tubular inhibiting agents on the urinary output of sulphates.
Topics: Acetazolamide; Blood Pressure; Diuretics; Humans; Organomercury Compounds; p-Aminohippuric Acid; Probenecid; Sulfates | 1961 |
EFFECT OF SOME TUBULAR INHABITING AGENTS ON THE URINARY OUTPUT OF TOTAL GLUCURONIDES.
Topics: Acetazolamide; Diuretics; Glucuronates; Glucuronides; Kidney Function Tests; Kidney Tubules; Organomercury Compounds; p-Aminohippuric Acid; Pharmacology; Phenolphthaleins; Probenecid; Rabbits; Research; Urine | 1963 |
STUDIES ON THE RATE OF RUNOUT OF N-METHYLNICOTIAMIDE FROM DOG RENAL SLICES.
Topics: Antimetabolites; Cyanides; Dinitrophenols; Dogs; Iodoacetates; Kidney; Malonates; Metabolism; Niacin; Niacinamide; p-Aminohippuric Acid; Pharmacology; Probenecid; Research; Tetraethylammonium Compounds; Tolazoline | 1964 |
FACTORS INFLUENCING RENAL EXCRETION OF FOREIGN ORGANIC ACIDS.
Topics: Acetates; Anilides; Animals; Benzoates; Benzothiadiazines; Bicarbonates; Dinitrophenols; Dogs; Fluids and Secretions; Gentisates; Hydrogen-Ion Concentration; Kidney; Kidney Tubules; Metabolism; Nitrobenzenes; p-Aminohippuric Acid; Phenylbutazone; Probenecid; Quinolines; Renal Elimination; Research; Salicylic Acid; Succinates; Sulfinpyrazone; Uricosuric Agents; Urine | 1964 |
KINETIC STUDIES ON TRANSPORT OF PAH AND OTHER ORGANIC ACIDS IN ISOLATED RENAL TUBULES.
Topics: Aminohippuric Acids; Animals; Biological Transport; Dinitrophenols; Extracellular Space; Hippurates; Inulin; Kidney Tubules; Kinetics; p-Aminohippuric Acid; Pharmacology; Probenecid; Rabbits; Research | 1965 |
INHIBITORS OF PENICILLIN BINDING TO SERUM PROTEINS.
Topics: Acetazolamide; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimetabolites; Aspirin; Benzoates; Biguanides; Blood Proteins; Carbon Isotopes; Chlorothiazide; Diuretics; Ethacrynic Acid; Guanidines; Oxazoles; p-Aminohippuric Acid; Penicillin G; Penicillin V; Penicillins; Pharmacology; Phenylbutazone; Probenecid; Rabbits; Research; Salicylates; Sulfinpyrazone; Sulfonamides; Tolbutamide | 1965 |
Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney.
Topics: Animals; Antiviral Agents; Cimetidine; Glomerular Filtration Rate; Guanosine; Male; Metabolic Clearance Rate; Nephrons; p-Aminohippuric Acid; Perfusion; Probenecid; Rats; Thioinosine; Tissue Distribution | 2004 |
Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.
Topics: Animals; Binding, Competitive; Blotting, Western; Carrier Proteins; Cell Line; Computer Systems; Dogs; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Insecta; Kidney; Membrane Transport Modulators; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Osmolar Concentration; p-Aminohippuric Acid; Polymerase Chain Reaction; Probenecid; Rats; Rats, Mutant Strains; Rats, Wistar; RNA, Messenger; Sulfinpyrazone | 2004 |
Characterization of secretory intestinal transport of phenolsulfonphthalein.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Chromatography, High Pressure Liquid; Indomethacin; Intestinal Mucosa; Intestines; Kinetics; Male; p-Aminohippuric Acid; Permeability; Phenolsulfonphthalein; Probenecid; Rats; Rats, Wistar | 2005 |
Functional expression of pig renal organic anion transporter 3 (pOAT3).
Topics: Amino Acid Sequence; Animals; Dehydroepiandrosterone Sulfate; DNA, Complementary; Estrone; Glutarates; Humans; Kidney; Mice; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Rabbits; Rats; Sequence Homology, Amino Acid; Swine; Uricosuric Agents; Xenopus laevis | 2005 |
Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1.
Topics: Acetylcysteine; Amino Acids; Animals; Biological Transport; Cell Line; Cell Survival; Dogs; Dose-Response Relationship, Drug; Humans; Kidney; Methylmercury Compounds; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Temperature; Transfection | 2005 |
Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters.
Topics: Amino Acid Transport Systems; Animals; Cell Survival; Dicarboxylic Acids; DNA, Complementary; Dogs; Epithelial Cells; Homocysteine; Kidney; Leucine; Methylmercury Compounds; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Transfection; Uricosuric Agents | 2005 |
Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Cysteine; Dicarboxylic Acids; Dogs; Dose-Response Relationship, Drug; Epithelial Cells; Glutarates; Humans; Kidney; Leucine; Methylmercury Compounds; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Temperature; Transfection; Tritium; Uricosuric Agents | 2005 |
Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture.
Topics: Animals; Biological Transport, Active; Bromcresol Green; Carbon Radioisotopes; Chickens; Cimetidine; Cytochalasins; DNA Primers; Electric Impedance; Epithelium; Estrone; Glutarates; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Lithium; Membrane Potentials; Nocodazole; Organic Anion Transporters; Ouabain; p-Aminohippuric Acid; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uric Acid | 2005 |
Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Biological Transport; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Estrone; GABA Modulators; Herbicides; Mice; Ochratoxins; Organic Anion Transporters; p-Aminohippuric Acid; Penicillin G; Probenecid; Salicylates; Transfection; Uricosuric Agents; Xenopus laevis | 2006 |
Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters.
Topics: Algorithms; Anesthesia; Animals; Autoradiography; Biological Transport; Blood Pressure; Blood-Brain Barrier; Brain; Capillaries; Carrier Proteins; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Diffusion; Heart Rate; Kinetics; p-Aminohippuric Acid; Pharmaceutical Preparations; Probenecid; Rats; Rats, Sprague-Dawley; Sucrose | 2007 |
Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1).
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cyclophosphamide; Dehydroepiandrosterone Sulfate; Gene Library; Glutarates; Humans; Immunohistochemistry; Kinetics; Male; Membrane Transport Proteins; Mice; Microinjections; Molecular Sequence Data; Oocytes; p-Aminohippuric Acid; Probenecid; RNA, Messenger; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Sertoli Cells; Sodium; Testis; Xenopus laevis | 2007 |
Progesterone inhibits folic acid transport in human trophoblasts.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; ATP-Binding Cassette Transporters; Estradiol; Folic Acid; Humans; Indoles; Indomethacin; Kinetics; p-Aminohippuric Acid; Probenecid; Progesterone; Trophoblasts; Verapamil | 2007 |
Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
Topics: Adenosine Triphosphate; Angiotensin II Type 1 Receptor Blockers; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Dogs; Dose-Response Relationship, Drug; Estrone; Female; Hepatocytes; Humans; Imidazoles; In Vitro Techniques; Kidney; Kinetics; Liver; Liver-Specific Organic Anion Transporter 1; Membrane Transport Proteins; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Olmesartan Medoxomil; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Probenecid; Prodrugs; Protein Binding; Protein Isoforms; Sincalide; Solute Carrier Organic Anion Transporter Family Member 1B3; Tetrazoles; Transfection | 2007 |
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
Topics: Animals; Cimetidine; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Organic Anion Transporters; Organic Cation Transport Proteins; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Substrate Specificity; Tetraethylammonium; Time Factors; Xanthines | 2007 |
Organic anion transporter OAT1 is involved in renal handling of citrulline.
Topics: Animals; Biological Transport; Catecholamine Plasma Membrane Transport Proteins; Cefazolin; Cell Line; Citrulline; Glutarates; Humans; Kidney; Male; Models, Animal; Octamer Transcription Factor-1; Octamer Transcription Factor-2; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar | 2009 |
Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Cells, Cultured; DNA Adducts; Extracellular Space; Female; Humans; Kidney; Kidney Diseases; Oocytes; Organic Anion Transporters; p-Aminohippuric Acid; Probenecid; Renal Agents; Xenopus laevis | 2009 |
Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Biological Transport; Estrone; Humans; Kinetics; Kynurenic Acid; Kynurenine; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Quinolinic Acid; Xenopus laevis | 2012 |
Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Biological Transport; Caco-2 Cells; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Monocarboxylic Acid Transporters; p-Aminohippuric Acid; Permeability; Probenecid; Temperature; Time Factors | 2012 |
First evidence of epithelial transport in tardigrades: a comparative investigation of organic anion transport.
Topics: 2,4-Dinitrophenol; Animals; Biological Transport, Active; Grasshoppers; Ion Transport; Macrolides; Malpighian Tubules; Membrane Potentials; Mitochondria; Organic Anion Transporters; p-Aminohippuric Acid; Phenolsulfonphthalein; Probenecid; Sodium-Potassium-Exchanging ATPase; Tardigrada | 2012 |
Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers.
Topics: Drug Interactions; Estrone; HEK293 Cells; Humans; Kidney; Lansoprazole; Methotrexate; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Pemetrexed; Probenecid; Proton Pump Inhibitors; Stereoisomerism | 2018 |
Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor.
Topics: Animals; Cell Proliferation; CHO Cells; Cricetulus; Diterpenes; Herb-Drug Interactions; Humans; Molecular Docking Simulation; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid | 2019 |