Page last updated: 2024-08-16

probenecid and methotrexate

probenecid has been researched along with methotrexate in 98 studies

Research

Studies (98)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (33.67)	18.7374
1990's	14 (14.29)	18.2507
2000's	30 (30.61)	29.6817
2010's	21 (21.43)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Graves, P; Kuze, K; Leahy, A; Stuhlmann, H; Wilson, P; You, G	1
Chan, BS; Lu, R; Schuster, VL	1
Hashimoto, Y; Ibaramoto, K; Inui, KI; Masuda, S; Saito, H; Takeuchi, A	1
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Bakos, E; Borst, P; Evers, R; Sarkadi, B; Sinkó, E; Váradi, A	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Belinsky, MG; Chen, ZS; Kruh, GD; Rea, PA; Zeng, H	1
Bindels, RJM; Peters, JGP; Russel, FGM; Smeets, PHE; van Aubel, RAMH	1
Cha, SH; Endou, H; Hosoyamada, M; Khamdang, S; Kimura, H; Narikawa, S; Sekine, T; Takeda, M	1
Berryman, E; Chen, C; Franco, J; Hanson, E; Liu, X; Scott, D; Volberg, M	1
Hummel-Eisenbeiss, J; Jedlitschky, G; Keppler, D; Nies, AT; Rius, M	1
Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T	1
Belinsky, MG; Chen, ZS; Guo, Y; Kotova, E; Kruh, GD	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Eraly, SA; Kaler, G; Khandelwal, A; Nagle, M; Nigam, SK; Swaan, PW; Truong, DM	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Masseno, V; Muriithi, S; Nzila, A	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Fent, K; Popovic, M; Smital, T; Zaja, R	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Huang, KC; Liu, YK; Wenczak, BA	1
Biddlecome, SM; Bourke, RS; Kimelberg, HK	1
Howell, SB; Olshen, RA; Rice, JA	1
Blaschke, T; Fusner, JE; Glaubiger, DL; Ramu, A	1
Aherne, GW; Marks, V; Mould, G; Piall, E; White, WF	1
Aherne, GW; Marks, V; Mould, GP; Piall, E; White, WF	1
Blaschke, TF; Eldridge, N; Glaubiger, D; Ramu, A; Ramu, NP	1
Domer, FR; Kaiser, LR	1
Kates, RE; Sorby, DL; Tozer, TN	1
Kates, RE; Tozer, TN	1
Spector, R	1
Bourke, RS; Bremer, A; Chheda, G; Tower, DB; Watanabe, O	1
Henderson, GB	1
Henderson, GB; Strauss, BP	1
O'Leary, DF; Sirotnak, FM	1
Basin, KS; Beardmore, TD; Escalante, A	1
Henderson, GB; Tsuji, JM	1
Weinblatt, ME	1
Besseghir, K; Mosig, D; Roch-Ramel, F	1
Furst, DE	1
Brasch, H; Iven, H	2
Gale, GR; Hynes, JB; Smith, AB	1
Lilly, MB; Omura, GA	1
Christensen, ML; Evans, WE	1
Henderson, GB; Kumar, HP; Tsuji, JM	1
Gewirtz, DA; Holt, SA	1
Henderson, GB; Zevely, EM	1
Fry, DW; Goldman, ID; Yalowich, JC	1
Brooks, PM; Buchanan, WW; Kassam, Y; Kean, WF	1
Bleyer, WA; Gangji, D; Glaubiger, DL; Poplack, DG; Ross, WE	1
Paxton, JW	1
Gewirtz, DA; Plotkin, JH; Randolph, JK	1
Nierenberg, DW	1
Borthwick-Clarke, C; Gravett, PJ	1
Hancock, CH; Moccio, DM; Sirotnak, FM; Young, CW	1
Bleyer, WA; Bode, U; Glaubiger, DL; Magrath, IT; Poplack, DG	1
Moccio, DM; Sirotnak, FM; Young, CW	1
Brigle, KE; Goldman, ID; Sierra, EE; Spinella, MJ	2
Henderson, GB; Hughes, TR	1
McCloud, E; Mohammadkhani, R; Said, HM	1
Hashimoto, Y; Inui, K; Okuda, M; Takami, K; Uwai, Y	1
Bacher, JD; Balis, FM; Blaney, SM; McCully, CL; Murphy, RF; Poplack, DG	1
Inui, K; Saito, H; Uwai, Y	1
Kato, Y; Komatsu, K; Sugiyama, Y; Ueda, K	1
Adamson, PC; Balis, FM; McCully, C; Salzer, W; Widemann, B	1
Fujisawa, R; Hanada, K; Kataoka, R; Nakamura, S; Ogata, H	1
Horne, DW; Reed, KA	1
Cai, S; Horne, DW	1
Lim, BG; Ng, KH; Wong, KP	1
Chen, V; Dantzig, AH; Perry, WI; Pratt, S; Starling, JJ	1
Hamada, N; Nagai, J; Ogawa, K; Takano, M; Yumoto, R	1
Itoh, T; Narawa, T; Tsuda, Y	1
Announ, N; Guerne, PA	1
Böhlke, M; Henry, K; Kim, J; Maher, TJ; Sani, SN; Stricker-Krongrad, A	1
Chakilam, AR; Jayaraj, A; Taft, DR; Tamhane, M; Thakkar, V	1
Mori, N; Murakami, T; Yokooji, T	1
Beveridge, S; Biagini, GA; Bray, PG; Johnson, D; Krishna, S; Nzila, A; O'Neill, PM; Ochong, E; Salcedo-Sora, JE; Stocks, PA; Ward, SA	1
Agarwal, S; Elmquist, WF; Li, L	1
Danhof, M; de Lange, EC; Hartman, R; van den Berg, DJ; Westerhout, J	1
Flores, K; Manautou, JE; Renfro, JL	1
Hamada, Y; Ikemura, K; Iwamoto, T; Okuda, M	1
Gynther, M; Huttunen, J; Huttunen, KM	1

Reviews

6 review(s) available for probenecid and methotrexate

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinically important interactions of nonsteroidal antiinflammatory drugs with other medications. The Journal of rheumatology. Supplement, 1988, Volume: 17 Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diuretics; Drug Interactions; Humans; Hypoglycemic Agents; Lithium; Methotrexate; Phenytoin; Probenecid; Salicylates; Triamterene	1988
Drug interactions with methotrexate. The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12 Topics: Absorption; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Biological Transport; Cell Membrane; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Folic Acid; Humans; Kidney Tubules; Methotrexate; Probenecid; Protein Binding; Salicylates; Serum Albumin; Sulfamethoxazole; Sulfonamides; Tissue Distribution	1985
Problems of antiarthritic therapy in the elderly. Journal of the American Geriatrics Society, 1984, Volume: 32, Issue:3 Topics: Adrenal Cortex Hormones; Age Factors; Aged; Allopurinol; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Chloroquine; Female; Gold; Gout; Humans; Male; Methotrexate; Middle Aged; Osteoarthritis; Penicillamine; Probenecid	1984
Treating difficult crystal pyrophosphate dihydrate deposition disease. Current rheumatology reports, 2008, Volume: 10, Issue:3 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Calcium Pyrophosphate; Chondrocalcinosis; Colchicine; Glucocorticoids; Humans; Magnesium Compounds; Methotrexate; Probenecid; Uricosuric Agents	2008

Trials

1 trial(s) available for probenecid and methotrexate

Article	Year
Clinical pharmacology of oral intermediate-dose methotrexate with or without probenecid. Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:3 Topics: Administration, Oral; Clinical Trials as Topic; Drug Administration Schedule; Humans; Methotrexate; Neoplasms; Probenecid	1985

Other Studies

91 other study(ies) available for probenecid and methotrexate

Article	Year
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. The Journal of biological chemistry, 1999, Jan-15, Volume: 274, Issue:3 Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; COS Cells; Glycosylation; Histidine; In Situ Hybridization; Kidney; Kinetics; Mice; p-Aminohippuric Acid; Probenecid; Protein Processing, Post-Translational; Renal Agents; Substrate Specificity; Tunicamycin	1999
Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. The American journal of physiology, 1999, Volume: 276, Issue:2 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; DNA, Complementary; HeLa Cells; Humans; Kidney; Molecular Sequence Data; p-Aminohippuric Acid; Protein Kinase C; Rats; Substrate Specificity; Tissue Distribution	1999
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Molecular pharmacology, 1999, Volume: 55, Issue:4 Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Kidney; Male; Membrane Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Oocytes; Organic Anion Transporters; Rats; Rats, Wistar; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tissue Distribution; Transfection; Xenopus laevis	1999
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Molecular pharmacology, 2000, Volume: 57, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anions; Biological Transport; Cell Membrane; Cells, Cultured; DNA-Binding Proteins; Drug Resistance, Multiple; Glutathione; Humans; Insecta; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer research, 2001, Oct-01, Volume: 61, Issue:19 Topics: 3T3 Cells; Animals; ATP-Binding Cassette Transporters; Biological Transport; Drug Resistance, Multiple; Folic Acid; Humans; Leucovorin; Methotrexate; Mice; Multidrug Resistance-Associated Proteins; Osmolar Concentration; Polyglutamic Acid; Tritium	2001
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:3 Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Cyclic AMP; Cyclic GMP; Estradiol; Humans; Immunohistochemistry; Insecta; Kidney Tubules, Proximal; Methotrexate; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Rats; Tissue Distribution	2002
Characterization of methotrexate transport and its drug interactions with human organic anion transporters. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cells, Cultured; Humans; Indomethacin; Kinetics; Liver-Specific Organic Anion Transporter 1; Methotrexate; Mice; Mice, Transgenic; Nerve Tissue Proteins; Organic Anion Transporters, Sodium-Independent; Phenylbutazone; Potassium Channels; Potassium Channels, Tandem Pore Domain; Probenecid	2002
Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats. Pharmaceutical research, 2003, Volume: 20, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Biliary Tract; Carrier Proteins; Furosemide; Hyperbilirubinemia; Intestinal Absorption; Male; Methotrexate; Probenecid; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley	2003
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:2 Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Polarity; Cholagogues and Choleretics; Cricetinae; Fibroblasts; Gene Expression; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Rats; Taurocholic Acid; Transfection; Transport Vesicles; Tritium	2003
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger	2004
Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Molecular pharmacology, 2005, Volume: 67, Issue:2 Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Dose-Response Relationship, Drug; Estradiol; Humans; Leukotriene C4; LLC-PK1 Cells; Protein Transport; Swine	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. The Journal of biological chemistry, 2007, Aug-17, Volume: 282, Issue:33 Topics: Binding Sites; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Static Electricity; Substrate Specificity	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide. The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47 Topics: Animals; Evolution, Molecular; Glycosylation; Gonadal Steroid Hormones; HEK293 Cells; Humans; Ion Transport; Organic Anion Transporters; Protein Multimerization; Zebrafish; Zebrafish Proteins	2013
Renal tubular transport of methotrexate in the rhesus monkey and dog. Cancer research, 1979, Volume: 39, Issue:12 Topics: Animals; Biological Transport, Active; Dogs; Female; Folic Acid; Haplorhini; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Macaca mulatta; Methotrexate; Probenecid; Protein Binding; Species Specificity	1979
Distribution and degradation of [3H]methotrexate after intravenous and cerebral intraventricular injection in primates. Cancer research, 1977, Volume: 37, Issue:1 Topics: Animals; Bone Marrow; Brain; Cats; Female; Haplorhini; Infusions, Parenteral; Injections, Intravenous; Injections, Intraventricular; Kidney; Liver; Macaca fascicularis; Macaca mulatta; Male; Methotrexate; Probenecid; Spleen; Time Factors	1977
Effect of probenecid on cerebrospinal fluid methotrexate kinetics. Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:5 Topics: Adult; Child, Preschool; Female; Humans; Kinetics; Methotrexate; Middle Aged; Neoplasms; Probenecid	1979
Probenecid inhibition of methotrexate-cerebrospinal fluid pharmacokinetics in dogs. Cancer treatment reports, 1978, Volume: 62, Issue:10 Topics: Animals; Cisterna Magna; Dogs; Drug Interactions; Half-Life; Injections; Injections, Spinal; Kinetics; Methotrexate; Probenecid	1978
Prolongation and enhancement of serum methotrexate concentrations by probenecid. British medical journal, 1978, Apr-29, Volume: 1, Issue:6120 Topics: Adult; Aged; Drug Interactions; Female; Humans; Infusions, Parenteral; Injections, Intravenous; Kinetics; Male; Methotrexate; Middle Aged; Probenecid	1978
The interaction between methotrexate and probenecid in man [proceedings]. British journal of pharmacology, 1978, Volume: 63, Issue:2 Topics: Drug Interactions; Humans; Methotrexate; Probenecid	1978
Probenecid inhibition of methotrexate excretion from cerebrospinal fluid in dogs. Journal of pharmacokinetics and biopharmaceutics, 1978, Volume: 6, Issue:5 Topics: Animals; Dogs; Drug Interactions; Kinetics; Methotrexate; Probenecid	1978
Effects of probenecid on methotrexate exchange between the blood and the cerebrospinal fluid. Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 225, Issue:1 Topics: Animals; Female; Injections, Intravenous; Male; Methotrexate; Perfusion; Probenecid; Rabbits; Time Factors	1977
Increased methotrexate toxicity due to concurrent probenecid administration. Biochemical pharmacology, 1976, Jul-01, Volume: 25, Issue:13 Topics: Animals; Bile; Diarrhea; Drug Synergism; Male; Methotrexate; Probenecid; Rats; Time Factors	1976
Biliary secretion of methotrexate in rats and its inhibition by probenecid. Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:9 Topics: Animals; Bile; Kinetics; Male; Metabolic Clearance Rate; Methotrexate; Probenecid; Rats	1976
Inhibition of methotrexate transport from cerebrospinal fluid by probenecid. Cancer treatment reports, 1976, Volume: 60, Issue:7 Topics: Animals; Antineoplastic Agents; Choroid Plexus; In Vitro Techniques; Methotrexate; Probenecid; Rabbits	1976
Inhibition of renal tubular transport of methotrexate by probenecid. Cancer research, 1975, Volume: 35, Issue:1 Topics: Aminohippuric Acids; Animals; Biological Transport; Blood Proteins; Carbon Radioisotopes; Depression, Chemical; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Injections, Intravenous; Inulin; Kidney Glomerulus; Kidney Tubules; Macaca; Methotrexate; Probenecid; Protein Binding; Tritium	1975
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells. Biochimica et biophysica acta, 1992, Oct-05, Volume: 1110, Issue:2 Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Leukemia L1210; Methotrexate; Mice; Probenecid; Prostaglandins A; Quinidine; Reserpine; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil; Vincristine	1992
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump. The Journal of biological chemistry, 1991, Jan-25, Volume: 266, Issue:3 Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol; Methotrexate; Probenecid; Prostaglandins A; Rats; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil	1991
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors. Cancer research, 1991, Mar-01, Volume: 51, Issue:5 Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Probenecid; Sulfobromophthalein; Verapamil	1991
Severe pancytopenia in a patient taking low dose methotrexate and probenecid. The Journal of rheumatology, 1991, Volume: 18, Issue:4 Topics: Aged; Arthritis, Rheumatoid; Blood Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Methotrexate; Pancytopenia; Probenecid	1991
Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells. Biochimica et biophysica acta, 1990, Jan-23, Volume: 1051, Issue:1 Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cholic Acids; Cytochalasin B; Folic Acid; Glucose; Leukemia L1210; Methotrexate; Mice; Probenecid; Substrate Specificity; Sulfobromophthalein; Temperature; Tumor Cells, Cultured; Uric Acid; Vincristine	1990
Drug interactions with non steroidal anti-inflammatory drugs (NSAIDs). Scandinavian journal of rheumatology. Supplement, 1989, Volume: 83 Topics: Administration, Oral; Aged; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antihypertensive Agents; Drug Interactions; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Lithium; Methotrexate; Phenytoin; Probenecid	1989
Transport of methotrexate by the in vitro isolated rabbit proximal tubule. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2 Topics: Absorption; Animals; Biological Transport; Female; Folic Acid; In Vitro Techniques; Kidney Tubules, Proximal; Male; Methotrexate; Perfusion; Probenecid; Rabbits	1989
The effects of antibiotics and uricosuric drugs on the renal elimination of methotrexate and 7-hydroxymethotrexate in rabbits. Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:4 Topics: Animals; Anti-Bacterial Agents; Benzbromarone; Ceftriaxone; Furosemide; Kidney; Metabolic Clearance Rate; Methotrexate; Piperacillin; Probenecid; Rabbits; Sulfamethoxazole; Sulfinpyrazone; Uricosuric Agents	1988
Influence of the antibiotics piperacillin, doxycycline, and tobramycin on the pharmacokinetics of methotrexate in rabbits. Cancer chemotherapy and pharmacology, 1986, Volume: 17, Issue:3 Topics: Animals; Anti-Bacterial Agents; Doxycycline; Drug Interactions; Kinetics; Male; Methotrexate; Piperacillin; Probenecid; Rabbits; Tobramycin	1986
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil. Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Probenecid; Quinazolines; Time Factors; Verapamil	1986
Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells. Cancer research, 1986, Volume: 46, Issue:4 Pt 1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cells, Cultured; Glucose; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Leukemia; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Oligomycins; Probenecid; Sulfobromophthalein; Tetrahydrofolates; Tritium	1986
Protein binding as a component of drug interaction in cellular pharmacokinetic studies. Effects of probenecid on transport and accumulation of methotrexate in Ehrlich ascites tumor cells in vitro. Biochemical pharmacology, 1985, Mar-15, Volume: 34, Issue:6 Topics: Animals; Biological Transport; Blood Proteins; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Methotrexate; Mice; Mice, Inbred Strains; Probenecid; Protein Binding; Serum Albumin	1985
Inhibitory effects of probenecid on the individual transport routes which mediate the influx and efflux of methotrexate in L1210 cells. Biochemical pharmacology, 1985, May-15, Volume: 34, Issue:10 Topics: Animals; Biological Transport; Cells, Cultured; Energy Metabolism; Leukemia L1210; Methotrexate; Mice; Probenecid; Sulfates	1985
Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells. Cancer research, 1982, Volume: 42, Issue:7 Topics: Animals; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Peptides; Polyglutamic Acid; Probenecid; Vincristine	1982
Probenecid inhibition of methotrexate cytotoxicity in mouse L1210 leukemia cells. Cancer treatment reports, 1984, Volume: 68, Issue:3 Topics: Animals; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Interactions; Interphase; Leukemia L1210; Methotrexate; Mice; Probenecid	1984
Interaction of probenecid with the protein binding of methotrexate. Pharmacology, 1984, Volume: 28, Issue:2 Topics: Drug Interactions; Half-Life; Humans; Methotrexate; Probenecid; Protein Binding; Serum Albumin; Ultrafiltration	1984
Interaction of probenecid with methotrexate transport and release in the isolated rat hepatocyte in suspension. Cancer research, 1984, Volume: 44, Issue:9 Topics: Animals; Biological Transport; In Vitro Techniques; Kinetics; Liver; Male; Methotrexate; Probenecid; Protein Binding; Rats; Rats, Inbred Strains; Tetrahydrofolate Dehydrogenase; Tritium	1984
Competitive inhibition of methotrexate accumulation in rabbit kidney slices by nonsteroidal anti-inflammatory drugs. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1 Topics: 2,4-Dinitrophenol; Animals; Anti-Inflammatory Agents; Aspirin; Binding, Competitive; Dinitrophenols; Kidney Cortex; Kinetics; Methotrexate; Nitrogen; p-Aminohippuric Acid; Probenecid; Rabbits	1983
The use of granulocyte transfusion: a case report. Journal of the Royal Army Medical Corps, 1980, Volume: 126, Issue:2 Topics: Adult; Blood Transfusion; Choriocarcinoma; Female; Granulocytes; Humans; Methotrexate; Military Medicine; Platelet Transfusion; Pregnancy; Probenecid; Uterine Neoplasms	1980
Improved methotrexate therapy of murine tumors obtained by probenecid-mediated pharmacological modulation at the level of membrane transport. Cancer research, 1981, Volume: 41, Issue:10 Topics: Animals; Biological Transport, Active; Bone Marrow; Female; Kidney; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Mice, Inbred Strains; Probenecid; Sarcoma 180	1981
Active transport of methotrexate from cerebrospinal fluid in humans. Cancer research, 1980, Volume: 40, Issue:7 Topics: Acetazolamide; Adolescent; Biological Transport, Active; Cerebral Ventricles; Child; Half-Life; Humans; Infusions, Parenteral; Injections, Intraventricular; Kinetics; Methotrexate; Probenecid	1980
Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux. Cancer research, 1981, Volume: 41, Issue:3 Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Probenecid; Sarcoma, Experimental	1981
Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells. Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8 Topics: Animals; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Probenecid; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Tumor Cells, Cultured	1995
Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. The Journal of biological chemistry, 1995, Apr-07, Volume: 270, Issue:14 Topics: Alkenes; Animals; Biological Transport; Carrier Proteins; Energy Metabolism; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Ions; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Polyenes; Probenecid; Pyrones; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Temperature; Transfection; Tumor Cells, Cultured	1995
Altered expression of unidirectional extrusion routes for methotrexate and cholate in an efflux variant of L1210 cells. Biochimica et biophysica acta, 1993, Oct-10, Volume: 1152, Issue:1 Topics: Animals; Cell Division; Cholic Acids; Drug Interactions; Drug Tolerance; Exocytosis; Leukemia L1210; Methotrexate; Mice; Probenecid; Sulfobromophthalein; Tumor Cells, Cultured	1993
Mechanism of transport of riboflavin in rabbit intestinal brush border membrane vesicles. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1993, Volume: 202, Issue:4 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Folic Acid; Furosemide; Ileum; Intestinal Mucosa; Jejunum; Kinetics; Membrane Potentials; Methotrexate; Microvilli; Organ Specificity; Osmolar Concentration; Potassium; Probenecid; Rabbits; Riboflavin; Valinomycin	1993
Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS letters, 1998, Nov-06, Volume: 438, Issue:3 Topics: Animals; Anion Transport Proteins; Anions; Biological Transport; Carrier Proteins; Cell Membrane; Dicarboxylic Acids; Diterpenes; DNA Primers; DNA, Complementary; Female; Folic Acid; Glutarates; Kidney; Kinetics; Methotrexate; Oocytes; p-Aminohippuric Acid; Phorbol Esters; Probenecid; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Xenopus laevis	1998
Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration. Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Brain; Cerebral Ventricles; Dose-Response Relationship, Drug; Infusions, Intravenous; Infusions, Parenteral; Injections, Intraventricular; Macaca mulatta; Male; Metabolic Clearance Rate; Methotrexate; Probenecid; Subarachnoid Space; Uricosuric Agents	2000
Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. European journal of pharmacology, 2000, Dec-01, Volume: 409, Issue:1 Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Carrier Proteins; Kinetics; Methotrexate; Oocytes; Probenecid; Uricosuric Agents; Xenopus laevis	2000
Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3 Topics: Animals; Bile; Biliary Tract; Biological Transport, Active; Cytoplasmic Vesicles; Dose-Response Relationship, Drug; Drug Interactions; Hepatocytes; Liver; Male; Metabolic Clearance Rate; Methotrexate; Models, Biological; Probenecid; Rats; Rats, Sprague-Dawley	2001
Effect of probenecid on ventricular cerebrospinal fluid methotrexate pharmacokinetics after intralumbar administration in nonhuman primates. Cancer chemotherapy and pharmacology, 2001, Volume: 48, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Cerebral Ventricles; Cerebrospinal Fluid; Drug Administration Routes; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Lumbosacral Region; Macaca mulatta; Methotrexate; Probenecid; Toxicity Tests; Uricosuric Agents	2001
Sex-related differences in the renal disposition of the acidic metabolite of clentiazem in rat. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:10 Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Female; Folic Acid Antagonists; Kidney; Male; Methotrexate; Probenecid; Protein Binding; Rats; Rats, Sprague-Dawley; Renal Agents; Sex Characteristics	2001
Transport of methotrexate into LNCaP human prostate cancer cells. BioFactors (Oxford, England), 2002, Volume: 16, Issue:1-2 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Biological Transport; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methotrexate; Phosphates; Probenecid; Prostatic Neoplasms; Sulfates; Tumor Cells, Cultured	2002
Transport of 5-formyltetrahydrofolate into primary cultured rat astrocytes. Archives of biochemistry and biophysics, 2003, Feb-01, Volume: 410, Issue:1 Topics: 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Arsenates; Astrocytes; Biological Transport; Buffers; Cells, Cultured; Enzyme Inhibitors; Ethanol; Folic Acid; Hydrogen-Ion Concentration; Leucovorin; Methotrexate; Probenecid; Rats; Rats, Sprague-Dawley; Sodium Cyanide; Tetrahydrofolates	2003
Sulfate conjugating and transport functions of MDCK distal tubular cells. Kidney international, 2003, Volume: 63, Issue:3 Topics: Animals; Biological Transport; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclosporine; Glutathione; Harmine; Humans; Immunosuppressive Agents; Kidney Tubules, Distal; Leukotriene Antagonists; Liver; Membrane Transport Proteins; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Probenecid; Propionates; Quinolines; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sulfates; Uricosuric Agents	2003
Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Volume: 27, Issue:5 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Antimetabolites, Antineoplastic; Cyclic Nucleotide Phosphodiesterases, Type 5; Fluoresceins; Fluorescent Dyes; Glutamates; Guanine; HeLa Cells; Humans; Kinetics; Membrane Transport Proteins; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pemetrexed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Probenecid; Propionates; Quinolines; Reproducibility of Results; Staining and Labeling; Transfection	2006
Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy research, 2006, Volume: 71, Issue:1 Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Erythrocyte Membrane; Glutathione; Indomethacin; Methotrexate; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Transport Vesicles; Valproic Acid	2006
Chiral recognition of amethopterin enantiomers by the reduced folate carrier in Caco-2 cells. Drug metabolism and pharmacokinetics, 2007, Feb-25, Volume: 22, Issue:1 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Algorithms; Caco-2 Cells; Chromatography, Liquid; Folic Acid; Folic Acid Antagonists; Humans; Mass Spectrometry; Methotrexate; Probenecid; Proteins; Reduced Folate Carrier Protein; Stereoisomerism; Uricosuric Agents	2007
The effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study. Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cyclosporine; Drug Delivery Systems; Drug Interactions; Female; Humans; Methotrexate; Mice; Mice, Nude; Microdialysis; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplasms; Probenecid; Tissue Distribution; Xenograft Model Antitumor Assays	2010
Comparative renal excretion of VX-702, a novel p38 MAPK inhibitor, and methotrexate in the perfused rat kidney model. Drug development and industrial pharmacy, 2010, Volume: 36, Issue:3 Topics: Algorithms; Animals; Antirheumatic Agents; Cimetidine; Drug Interactions; Enzyme Inhibitors; Glomerular Filtration Rate; Immunologic Factors; Kidney; Kinetics; Male; Methotrexate; Organic Anion Transporters; Organic Cation Transport Proteins; Osmolar Concentration; p38 Mitogen-Activated Protein Kinases; Perfusion; Phenylurea Compounds; Probenecid; Rats; Rats, Sprague-Dawley; Ultrafiltration	2010
Modulated pharmacokinetics and increased small intestinal toxicity of methotrexate in bilirubin-treated rats. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:2 Topics: Alkaline Phosphatase; Animals; Biliary Tract; Bilirubin; Biological Transport; Drug Interactions; Hyperbilirubinemia; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methotrexate; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Sprague-Dawley	2011
The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. The Journal of biological chemistry, 2011, Dec-30, Volume: 286, Issue:52 Topics: Biological Transport, Active; Escherichia coli; Folic Acid; Folic Acid Antagonists; Folic Acid Transporters; Humans; Methotrexate; Plasmodium falciparum; Probenecid; Protozoan Proteins; Uricosuric Agents	2011
Brain efflux index to investigate the influence of active efflux on brain distribution of pemetrexed and methotrexate. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Capillary Permeability; Folic Acid Antagonists; Glutamates; Guanine; Half-Life; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Pemetrexed; Penicillin G; Probenecid	2013
Prediction of methotrexate CNS distribution in different species - influence of disease conditions. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Jun-16, Volume: 57 Topics: Adult; Age Factors; Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Central Nervous System; Child; Disease; Dogs; Humans; Male; Methotrexate; Microdialysis; Models, Biological; Organic Anion Transporters; Probenecid; Rats, Wistar; Reproducibility of Results; Species Specificity; Systems Biology; Tissue Distribution	2014
Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus. Toxicology, 2017, 07-01, Volume: 386 Topics: Animals; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Choroid Plexus; Female; Gene Expression Regulation; Kidney; Liver; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Probenecid; Sex Factors	2017
Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers. Pharmacology, 2018, Volume: 101, Issue:3-4 Topics: Drug Interactions; Estrone; HEK293 Cells; Humans; Kidney; Lansoprazole; Methotrexate; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Pemetrexed; Probenecid; Proton Pump Inhibitors; Stereoisomerism	2018
Targeted efflux transporter inhibitors - A solution to improve poor cellular accumulation of anti-cancer agents. International journal of pharmaceutics, 2018, Oct-25, Volume: 550, Issue:1-2 Topics: Antineoplastic Agents; Biological Transport; Cell Line; Drug Synergism; Humans; Membrane Transport Proteins; Methotrexate; Probenecid; Prodrugs; Vinblastine	2018