probenecid has been researched along with mercaptopurine in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Deguchi, T; Hosoya, K; Kang, YS; Mori, S; Ohtsuki, S; Takanaga, H; Terasaki, T | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Kaplowitz, N; Kuhlenkamp, J | 1 |
| Elfarra, AA; Hwang, IY | 1 |
| Sladek, NE | 1 |
| Deguchi, Y; Hayashi, H; Kimura, R; Naito, T; Sakamoto, T; Yamada, S; Yokoyama, Y | 1 |
| PIERCE, JC; VARCO, RL | 1 |
1 review(s) available for probenecid and mercaptopurine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
18 other study(ies) available for probenecid and mercaptopurine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.
Topics: Animals; Blood-Brain Barrier; Cimetidine; Convulsants; Endothelium, Vascular; Enzyme Inhibitors; Homovanillic Acid; Indican; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Rats; Rats, Wistar; Transfection; Tritium; Xenopus laevis | 2003 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Inhibition of hepatic metabolism of azathioprine in vivo.
Topics: Animals; Azathioprine; Glutathione; Liver; Male; Mercaptopurine; Probenecid; Rats | 1978 |
Kidney-selective prodrugs of 6-mercaptopurine: biochemical basis of the kidney selectivity of S-(6-purinyl)-L-cysteine and metabolism of new analogs in rats.
Topics: Aminooxyacetic Acid; Animals; Chromatography, High Pressure Liquid; Kidney; Male; Mercaptopurine; Probenecid; Prodrugs; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Therapeutic efficacy of cyclophosphamide as a function of inhibition of its metabolism.
Topics: Alkylation; Animals; Azaguanine; Binding, Competitive; Carcinoma 256, Walker; Cyclophosphamide; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Male; Meperidine; Mercaptopurine; Metyrapone; Microsomes, Liver; Morphine; Phenacetin; Proadifen; Probenecid; Quinine; Rats | 1972 |
Gout.
Topics: Allopurinol; Blood Cell Count; Cell Movement; Colchicine; Diet; Drug Synergism; Gastrointestinal Diseases; Gout; Hemorrhage; Humans; Indomethacin; Leukocytes; Mercaptopurine; Phenylbutazone; Probenecid; Purines; Uric Acid | 1974 |
Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier.
Topics: Animals; Blood Proteins; Blood-Brain Barrier; Brain; Ethylmaleimide; Male; Mercaptopurine; Metabolic Clearance Rate; Microdialysis; Probenecid; Protein Binding; Rats; Rats, Wistar | 2000 |
EFFECT OF 6-MERCAPTOPURINE ALONE AND IN COMBINATION WITH OTHER AGENTS UPON RENAL HOMOGRAFT REJECTION.
Topics: Allografts; Colchicine; Dietary Proteins; Dogs; Fluorouracil; Immunity; Iron; Kidney; Kidney Transplantation; Mercaptopurine; Pharmacology; Probenecid; Research | 1964 |