Page last updated: 2024-08-16

probenecid and lidocaine

probenecid has been researched along with lidocaine in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (29.17)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (33.33)	29.6817
2010's	9 (37.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bax, RP; Bywater, MJ; Holt, HA; Ings, RM; Reeves, DS; White, LO	1
Reeves, DS; Wise, R	1
Ball, GV; Freeman, D	1
Olsen, GA	1
Gray, RC; Nicol, CS; Phillips, I	1
Van der Linden, AJ	1
Riker, DK; Roth, RH; Zito, RA	1
Hashiguchi, M; Kasanuki, H; Rikihisa, T; Shiga, T; Urae, A	1

Reviews

1 review(s) available for probenecid and lidocaine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for probenecid and lidocaine

Article	Year
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Enzyme Inhibitors; Humans; Kidney; Lidocaine; Male; Probenecid; Reference Values; Uricosuric Agents	2000

Other Studies

22 other study(ies) available for probenecid and lidocaine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
The human pharmacokinetics of cefotaxime and its metabolites and the role of renal tubular secretion on their elimination. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:2 Topics: Adult; Blood Proteins; Cefotaxime; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Infusions, Parenteral; Injections, Intramuscular; Injections, Intravenous; Kidney Tubules; Kinetics; Lidocaine; Male; Middle Aged; Probenecid; Protein Binding; Time Factors	1985
Pharmacological studies on cephacetrile in human volunteers. Current medical research and opinion, 1974, Volume: 2, Issue:5 Topics: Adult; Bacillus subtilis; Bicarbonates; Blood; Buttocks; Cephalosporins; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Lidocaine; Male; Probenecid; Thigh; Urine	1974
Management of chronic and recurrent gout. Modern treatment, 1971, Volume: 8, Issue:4 Topics: Adrenocorticotropic Hormone; Allopurinol; Chronic Disease; Colchicine; Dexamethasone; Diet Therapy; Gout; Humans; Indomethacin; Lidocaine; Phenylbutazone; Prednisolone; Probenecid; Recurrence; Synovial Fluid; Uric Acid	1971
Epidemiological measures against gonorrhoea. Experience in Greenland. The British journal of venereal diseases, 1973, Volume: 49, Issue:2 Topics: Adolescent; Adult; Female; Gonorrhea; Greenland; Humans; Injections, Intramuscular; Lidocaine; Male; Penicillin G; Probenecid	1973
Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid. The British journal of venereal diseases, 1970, Volume: 46, Issue:5 Topics: Adult; Anti-Bacterial Agents; Gonorrhea; Humans; Lidocaine; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Probenecid	1970
Treatment of gonorrhoea. The New Zealand medical journal, 1981, May-27, Volume: 93, Issue:684 Topics: Drug Therapy, Combination; Gonorrhea; Humans; Lidocaine; Male; Penicillin G; Probenecid	1981
Lidocaine selectively diminishes medullary serotonin metabolism in the rat. Neuropharmacology, 1981, Volume: 20, Issue:12A Topics: Animals; Brain Stem; Corpus Striatum; Dopamine; Lidocaine; Medulla Oblongata; Norepinephrine; Probenecid; Rats; Rats, Inbred Strains; Serotonin	1981