probenecid has been researched along with indomethacin in 121 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (49.59) | 18.7374 |
| 1990's | 12 (9.92) | 18.2507 |
| 2000's | 34 (28.10) | 29.6817 |
| 2010's | 14 (11.57) | 24.3611 |
| 2020's | 1 (0.83) | 2.80 |
| Authors | Studies |
|---|---|
| Graves, P; Kuze, K; Leahy, A; Stuhlmann, H; Wilson, P; You, G | 1 |
| Chan, BS; Lu, R; Schuster, VL | 1 |
| Hashimoto, Y; Ibaramoto, K; Inui, KI; Masuda, S; Saito, H; Takeuchi, A | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Inui, K; Saito, H; Uwai, Y | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Beijnen, JH; Borst, P; Reid, G; Saeki, T; Zelcer, N | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Jung, KY; Kim, DK; Narikawa, S; Sekine, T; Takeda, M; Tojo, A; Yoo, BS | 1 |
| Boyd, CD; Iliás, A; Le Saux, O; Sarkadi, B; Seidl, TL; Sinkó, E; Urbán, Z; Váradi, A | 1 |
| Babu, E; Cha, SH; Endou, H; Enomoto, A; Kobayashi, Y; Narikawa, S; Sakthisekaran, D; Sekine, T; Takeda, M; Tojo, A | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Khamdang, S; Kimura, H; Narikawa, S; Sekine, T; Takeda, M | 1 |
| Deguchi, T; Hosoya, K; Kang, YS; Mori, S; Ohtsuki, S; Takanaga, H; Terasaki, T | 1 |
| Hong, J; Lambert, JD; Lee, SH; Sinko, PJ; Yang, CS | 1 |
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Belinsky, MG; Chen, ZS; Guo, Y; Kotova, E; Kruh, GD | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Podos, SM | 1 |
| Boss, GR; Seegmiller, JE | 1 |
| Bito, LZ; Wallenstein, MC | 3 |
| Emmerson, BT | 1 |
| Duggan, DE; Hooke, KF; Noll, RM; Stevenson, CR; White, SD | 1 |
| Simkin, PA | 1 |
| Benet, LZ | 1 |
| McCarty, DJ | 2 |
| Irish, JM | 1 |
| Baber, N; Halliday, L; Littler, T; Orme, ML; Sibeon, R | 1 |
| Lifschitz, MD; Patak, RV; Rosenblatt, SG | 1 |
| Bailie, MD; Crosslan, K; Hook, JB | 1 |
| Baroody, RA; Bito, LZ; Reitz, ME | 1 |
| Rennick, BR | 1 |
| Bito, LZ | 1 |
| Kelley, WN | 1 |
| Bell, MA; Brooks, PM; Dick, WC; Kennedy, AC; Sturrock, RD; Walker, JJ | 1 |
| Fritzsch, G; Klöss, S; Papavassiliou, F; Rumrich, G; Ullrich, KJ | 1 |
| Bishai, I; Coceani, F; Sirko, S | 1 |
| Brewerton, DA; Dixey, JJ; Lant, AF; Noormohamed, FH; Pawa, JS | 1 |
| Brater, DC; de Zeeuw, D; Jacobson, HR | 1 |
| Brewerton, DA; Dixey, JJ; Lant, AF; Noormohamed, FH | 1 |
| Aynedjian, HS; Bank, N; Satriano, JA; Schlondorff, D | 1 |
| Chalmers, D; Corrie, J; Hindawi, RK; Padfield, PL; Rademaker, M; Reid, MA; Williams, BC | 1 |
| Bidiville, J; Roch-Ramel, F | 1 |
| Gibson, T; Sinclair, H | 1 |
| Ellis, EF; Gamache, DA | 1 |
| Schlapbach, P | 1 |
| Lo, B | 1 |
| Hahn, I; Krieglstein, G; Krieglstein, J; Tschentscher, K | 1 |
| Zöllner, N | 1 |
| Sans Solá, L | 1 |
| Ball, GV; Freeman, D | 1 |
| Yü, T; Yu, TF | 1 |
| Häntzschel, H; Otto, W | 1 |
| Ignarro, LJ | 1 |
| Bluestone, R; Campion, D; Klinenberg, JR; Whitehouse, M | 1 |
| Goldfinger, SE | 1 |
| Klotz, H; Prohaska, E; Salmhofer, H; Schmid, L | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR | 1 |
| Motawakel, AG | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR; Whitehouse, M | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR; Whitehouse, MW | 1 |
| Callahan, M; Kensler, CJ; Remington, L; Yesair, DW | 1 |
| Riccitelli, ML | 1 |
| Griendl, W; Kalb, R; Klein, G | 1 |
| Rothermich, NO | 1 |
| Simkin, PA; Wisner, DE | 1 |
| Brion, N; Carbon, C; Contrepois, A; Cremieux, AC; Dromer, F | 1 |
| Rodnan, GP | 1 |
| Goodwin, JS; Staszak, C | 1 |
| Obel, AO | 1 |
| Brooks, PM; Meffin, PJ; Veenendaal, JR | 1 |
| van den Biggelaar-Martea, M; van Ewijk-Beneken Kolmer, EW; Verwey-van Wissen, CP; Vree, TB | 1 |
| van den Biggelaar-Martea, M; Verwey-van Wissen, CP; Vree, TB | 1 |
| Brandquist, C; Carney, D; Elmquist, WF; Huai-Yun, H; Mark, KS; Miller, DW; Secrest, DT | 1 |
| Benet, LZ; Lin, ET; Mizuma, T | 1 |
| McMartin, KE; Sikka, PK | 1 |
| Courtois, A; Fardel, O; Guillouzo, A; Lagadic, D; Payen, L | 1 |
| Courtois, A; Fardel, O; Guillouzo, A; Payen, L; Vernhet, L | 1 |
| Beijnen, J; Borst, P; de Haas, M; Evers, R; Lankelma, J; Sparidans, R; Wielinga, PR | 1 |
| Bandi, N; Kompella, UB | 1 |
| Benet, LZ; Flanagan, SD; Liu, X; Takahashi, LH | 1 |
| Crowe, A | 1 |
| Hara, Y; Hong, J; Lu, H; Meng, X; Ryu, JH; Yang, CS | 1 |
| REAH, TG | 1 |
| FROST, H | 1 |
| Adeyeye, MC; Gibbs, JP; Shen, DD; Yang, Z | 1 |
| Chiba, M; Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Miyazaki, K; Shimamoto, S; Sugawara, M | 1 |
| Capella, L; Capella, MA; Echevarria-Lima, J; Kyle-Cezar, F; P Leite, DF; Rumjanek, VM | 1 |
| Calixto, JB; Capella, MA; Echevarria-Lima, J; Leite, DF; Rumjanek, VM; Salgado, LT | 1 |
| Bertelsen, KM; Greenblatt, DJ; von Moltke, LL | 1 |
| Hamada, N; Nagai, J; Ogawa, K; Takano, M; Yumoto, R | 1 |
| Bridges, CC; Campos, I; Costa, F; Gonçalves, P; Keating, E; Lemos, C; Martel, F; Smith, SB | 1 |
| Hilgeroth, A; Langner, A; Richter, A; Richter, M | 1 |
| Nevala, H; Tähti, H; Ylikomi, T | 1 |
| Anzai, N; Endou, H; Enomoto, A; Fujimura, M; Miyazaki, H; Shin, HJ; Takeda, M | 1 |
| Duncton, MA; Singh, R | 1 |
11 review(s) available for probenecid and indomethacin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Indomethacin; Kidney; Kidney Calculi; Kidney Diseases; Lead Poisoning; Lymphoproliferative Disorders; Myeloproliferative Disorders; Phenylbutazone; Platelet Aggregation; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Uricosuric Agents | 1979 |
Transport of prostaglandins across the blood-brain and blood-aqueous barriers and the physiological significance of these absorptive transport processes.
Topics: Action Potentials; Animals; Anterior Chamber; Aqueous Humor; Biological Transport, Active; Blood; Blood-Brain Barrier; Body Temperature; Brain; Bromcresol Green; Electroretinography; Female; In Vitro Techniques; Indomethacin; Male; Probenecid; Prostaglandins; Rabbits; Retina; Uveitis; Visual Cortex | 1977 |
Drug control of gout and hyperuricaemia.
Topics: Allopurinol; Arthritis; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Naproxen; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1978 |
[Gout: diagnosis and therapy].
Topics: Allopurinol; Colchicine; Gout; Gout Suppressants; Humans; Indomethacin; Probenecid; Sulfinpyrazone | 1985 |
Crystal deposition joint disease.
Topics: Aged; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Crystallization; Diphosphates; Female; Gout; Humans; Indomethacin; Joint Diseases; Male; Phenylbutazone; Probenecid; Sulfinpyrazone; Synovial Fluid; Uric Acid; X-Ray Diffraction | 1974 |
Milestones in the treatment of gout.
Topics: Allopurinol; Colchicine; Gout; Humans; Indomethacin; Kidney Calculi; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1974 |
Treatment of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Gout; Humans; Indomethacin; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Xanthines | 1971 |
Treatment of the gout and other forms of crystal-induced arthritis.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzbromarone; Colchicine; Gout; Gout Suppressants; Humans; Indomethacin; Kidney; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1982 |
3 trial(s) available for probenecid and indomethacin
| Article | Year |
|---|---|
The influence of nonsteroidal anti-inflammatory drugs and probenecid on the renal response to and kinetics of piretanide in man.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Dinoprostone; Diuretics; Drug Interactions; Humans; Indomethacin; Kidney; Male; Natriuresis; Piroxicam; Probenecid; Random Allocation; Sulfonamides | 1988 |
Effect of maximal hydration on the renal responses to pretreatment with nonsteroidal anti-inflammatory drugs and probenecid in man.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Water; Diuresis; Drug Interactions; Humans; Indomethacin; Kidney; Male; Piroxicam; Probenecid | 1988 |
Effect of drugs on urate binding to plasma proteins.
Topics: Adult; Allopurinol; Arthritis; Aspirin; Blood Proteins; Chromatography, DEAE-Cellulose; Colchicine; Female; Gout; Humans; Indomethacin; Male; Phenylbutazone; Probenecid; Protein Binding; Sulfinpyrazone; Uric Acid | 1969 |
107 other study(ies) available for probenecid and indomethacin
| Article | Year |
|---|---|
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; COS Cells; Glycosylation; Histidine; In Situ Hybridization; Kidney; Kinetics; Mice; p-Aminohippuric Acid; Probenecid; Protein Processing, Post-Translational; Renal Agents; Substrate Specificity; Tunicamycin | 1999 |
Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; DNA, Complementary; HeLa Cells; Humans; Kidney; Molecular Sequence Data; p-Aminohippuric Acid; Protein Kinase C; Rats; Substrate Specificity; Tissue Distribution | 1999 |
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Kidney; Male; Membrane Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Oocytes; Organic Anion Transporters; Rats; Rats, Wistar; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tissue Distribution; Transfection; Xenopus laevis | 1999 |
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Carrier Proteins; Kinetics; Methotrexate; Oocytes; Probenecid; Uricosuric Agents; Xenopus laevis | 2000 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).
Topics: Animals; Biological Transport; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; DNA, Complementary; Drug Resistance, Multiple; Etoposide; Glutathione; Humans; Mice; Multidrug Resistance-Associated Proteins; Transfection | 2001 |
Characterization of ochratoxin A transport by human organic anion transporters.
Topics: Animals; Biological Transport; Cell Line; Humans; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Potassium | 2001 |
Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6).
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Biological Transport; Blotting, Western; Cell Line; Cell Membrane; DNA, Complementary; Dose-Response Relationship, Drug; Gene Library; Glutathione; Humans; Insecta; Kinetics; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Mutation; Mutation, Missense; Nucleotides; Protein Binding; Protein Biosynthesis; Pseudoxanthoma Elasticum; Time Factors; Transcription, Genetic | 2002 |
Role of human organic anion transporter 4 in the transport of ochratoxin A.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Humans; Immunohistochemistry; Kidney; Liver-Specific Organic Anion Transporter 1; Mice; Ochratoxins; Organic Anion Transporters, Sodium-Independent; Piroxicam; Probenecid; Recombinant Proteins; Transfection | 2002 |
Characterization of methotrexate transport and its drug interactions with human organic anion transporters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cells, Cultured; Humans; Indomethacin; Kinetics; Liver-Specific Organic Anion Transporter 1; Methotrexate; Mice; Mice, Transgenic; Nerve Tissue Proteins; Organic Anion Transporters, Sodium-Independent; Phenylbutazone; Potassium Channels; Potassium Channels, Tandem Pore Domain; Probenecid | 2002 |
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.
Topics: Animals; Blood-Brain Barrier; Cimetidine; Convulsants; Endothelium, Vascular; Enzyme Inhibitors; Homovanillic Acid; Indican; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Rats; Rats, Wistar; Transfection; Tritium; Xenopus laevis | 2003 |
Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.
Topics: Animals; Catechin; Cell Line; Dogs; Drug Resistance, Multiple; Multidrug Resistance-Associated Proteins | 2003 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Dose-Response Relationship, Drug; Estradiol; Humans; Leukotriene C4; LLC-PK1 Cells; Protein Transport; Swine | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Prostaglandins, nonsteroidal anti-inflammatory agents and eye disease.
Topics: Animals; Aqueous Humor; Arachidonic Acids; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Eye; Indomethacin; Intraocular Pressure; Probenecid; Prostaglandin Antagonists; Prostaglandins; Prostaglandins E; Rabbits | 1976 |
The effects of probenecid upon the individual components of indomethacin elimination.
Topics: Animals; Bile; Dogs; Enterohepatic Circulation; Haplorhini; Indomethacin; Macaca mulatta; Male; Metabolic Clearance Rate; Probenecid; Rats; Species Specificity | 1977 |
Management of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Female; Gout; Humans; Indomethacin; Patient Education as Topic; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1979 |
Pharmacokinetics/pharmacodynamics of furosemide in man: a review.
Topics: Biological Availability; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Heart Failure; Humans; Indomethacin; Kidney Diseases; Kinetics; Probenecid | 1979 |
The management of gout.
Topics: Allopurinol; Colchicine; Gout; Humans; Indomethacin; Male; Oxyphenbutazone; Phenylbutazone; Probenecid; Sulfinpyrazone | 1979 |
Secretion of prostaglandin E2 by rabbit proximal tubules.
Topics: Animals; Biological Transport, Active; Female; Indomethacin; Kidney Tubules, Proximal; Ouabain; p-Aminohippuric Acid; Probenecid; Prostaglandins E; Rabbits | 1979 |
Prostaglandin E1-induced alterations in visually-evoked response and production of epileptiform activity.
Topics: Acetaminophen; Animals; Bromcresol Green; Electroencephalography; Evoked Potentials; Female; Indomethacin; Photic Stimulation; Probenecid; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Rabbits; Seizures | 1977 |
Hyperthermic effects of supracortically applied prostaglandins after systemic pretreatment with inhibitors of prostaglandin transport and synthesis.
Topics: Acetaminophen; Animals; Body Temperature; Bromcresol Green; Cerebral Cortex; Drug Interactions; Female; Indomethacin; Male; Perfusion; Probenecid; Prostaglandins; Rabbits | 1978 |
The interaction between indomethacin and probenecid. A clinical and pharmacokinetic study.
Topics: Adult; Arthritis, Rheumatoid; Blood Proteins; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Indomethacin; Kinetics; Male; Middle Aged; Probenecid; Protein Binding | 1978 |
Organic acid secretory pathway and urinary excretion of prostaglandin E in the dog.
Topics: Animals; Diuresis; Dogs; Female; Glomerular Filtration Rate; Indomethacin; Kidney; Male; p-Aminohippuric Acid; Probenecid; Prostaglandins E | 1978 |
Natriuretic effect of furosemide after inhibition of prostaglandin synthetase.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Furosemide; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Meclofenamic Acid; Mixed Function Oxygenases; Natriuresis; Probenecid; Prostaglandins E; Regional Blood Flow; Renin; Urination; Vascular Resistance | 1976 |
Dependence of pulmonary prostaglandin metabolism on carrier-mediated transport processes.
Topics: Animals; Biological Transport, Active; Bromcresol Green; Indomethacin; Iodipamide; Lung; Probenecid; Prostaglandins; Rats; Sucrose | 1977 |
Renal tubular transport of prostaglandins: inhibition by probenecid and indomethacin.
Topics: Animals; Biological Transport, Active; Chickens; Indomethacin; Kidney Tubules; Probenecid; Prostaglandins E; Prostaglandins F; Prostaglandins, Synthetic | 1977 |
Drugs for gout.
Topics: Allopurinol; Colchicine; Gout; Humans; Indomethacin; Oxyphenbutazone; Phenylbutazone; Probenecid; Sulfinpyrazone | 1976 |
Inhibition of renal prostaglandin metabolism and excretion by probenecid, bromcresol green and indomethacin.
Topics: Animals; Bromcresol Green; Cresols; Depression, Chemical; In Vitro Techniques; Indomethacin; Kidney; Probenecid; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits | 1976 |
Current therapy of gout and hyperuricemia.
Topics: Allopurinol; Colchicine; Drug Interactions; Gout; Humans; Indomethacin; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
Proceedings: Ups and downs of indomethacin bioavailability.
Topics: Arthritis, Rheumatoid; Humans; Indomethacin; Probenecid | 1975 |
Contraluminal p-aminohippurate transport in the proximal tubule of the rat kidney. VII. Specificity: cyclic nucleotides, eicosanoids.
Topics: Animals; Biological Transport; Cyclic AMP; Cyclic GMP; Dicarboxylic Acids; Dinoprostone; Eicosanoids; Indomethacin; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Probenecid; Prostaglandin D2; Rats; Rats, Inbred Strains; Sulfates; Time Factors | 1991 |
Prostaglandin formation in the hypothalamus in vivo: effect of pyrogens.
Topics: Animals; Body Temperature; Cats; Dinoprostone; Endotoxins; Female; Fever; Hypothalamus; Indomethacin; Interleukin-1; Male; Probenecid; Pyrogens; Recombinant Proteins; Reference Values; Thromboxane B2 | 1989 |
Indomethacin secretion in the isolated perfused proximal straight rabbit tubule. Evidence for two parallel transport mechanisms.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Biological Transport, Active; Indomethacin; Kidney Tubules, Proximal; Kinetics; Organ Culture Techniques; p-Aminohippuric Acid; Probenecid; Rabbits; Sodium; Temperature | 1988 |
In vivo demonstration of glomerular PGE2 responses to physiological manipulations and experimental agents.
Topics: Angiotensin II; Animals; Dinoprostone; Indomethacin; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Probenecid; Prostaglandins E; Rats; Water-Electrolyte Balance | 1987 |
The role of renal dopamine and PGE2 in mediating the renal effects of the antihypertensive loop diuretic piretanide.
Topics: Dinoprostone; Diuresis; Diuretics; Dopamine; Humans; Indomethacin; Kidney; Loop of Henle; Male; Natriuresis; Probenecid; Prostaglandins E; Sulfonamides | 1987 |
Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit.
Topics: Aminohippuric Acids; Animals; Biological Transport; Female; Furosemide; Glomerular Filtration Rate; In Vitro Techniques; Indomethacin; Kidney; Male; Natriuresis; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rabbits; Time Factors; Tritium | 1986 |
Interaction between probenecid and indomethacin.
Topics: Drug Interactions; Female; Humans; Indomethacin; Middle Aged; Probenecid | 1986 |
Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Capillary Permeability; Carrageenan; Cerebrovascular Circulation; Dexamethasone; Encephalitis; Hindlimb; Ibuprofen; Indomethacin; Male; Mice; Mice, Inbred Strains; Probenecid | 1986 |
Hyperuricemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis; Colchicine; Female; Gout; Humans; Indomethacin; Kidney Calculi; Male; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1985 |
Distribution of chlorpromazine in a simplified blood influenced by various drugs.
Topics: Acetazolamide; Animals; Antidepressive Agents; Benzoates; Binding Sites; Binding, Competitive; Cattle; Chlorothiazide; Chlorpromazine; Coumarins; Deoxycholic Acid; Erythrocytes; Fatty Acids; Indomethacin; Phenylbutazone; Phenytoin; Probenecid; Protein Binding; Quinine; Salicylates; Serum Albumin, Bovine; Solubility; Sulfonamides; Suramin; Tetracycline; Thiopental | 1973 |
Zyloprim and other drugs in the management of gout.
Topics: Adrenocorticotropic Hormone; Colchicine; Enzyme Therapy; Enzymes; Gout; Humans; Indomethacin; Probenecid; Sulfinpyrazone; Urinary Calculi; Xanthine Oxidase | 1966 |
[The treatment of gout and the internal medical treatment of uric acid nephrolithiasis].
Topics: Adrenocorticotropic Hormone; Allopurinol; Colchicine; Gout; Humans; Indomethacin; Kidney Calculi; Prednisolone; Probenecid; Sulfinpyrazone; Uricosuric Agents | 1968 |
[How to treat gout].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticoagulants; Benzofurans; Colchicine; Gout; Griseofulvin; Humans; Indomethacin; Oxyphenbutazone; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone | 1966 |
Management of chronic and recurrent gout.
Topics: Adrenocorticotropic Hormone; Allopurinol; Chronic Disease; Colchicine; Dexamethasone; Diet Therapy; Gout; Humans; Indomethacin; Lidocaine; Phenylbutazone; Prednisolone; Probenecid; Recurrence; Synovial Fluid; Uric Acid | 1971 |
[Modern therapy of gout].
Topics: Acute Disease; Chronic Disease; Colchicine; Diet, Reducing; Female; Gout; Humans; Indomethacin; Kidney Calculi; Male; Phenylbutazone; Prednisolone; Probenecid; Pyelonephritis; Sex Factors | 1972 |
Gout.
Topics: Allopurinol; Blood Cell Count; Cell Movement; Colchicine; Diet; Drug Synergism; Gastrointestinal Diseases; Gout; Hemorrhage; Humans; Indomethacin; Leukocytes; Mercaptopurine; Phenylbutazone; Probenecid; Purines; Uric Acid | 1974 |
Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants.
Topics: Allopurinol; Arthritis, Rheumatoid; Aspirin; Cartilage; Chloroquine; Colchicine; Factor VIII; Glucuronidase; Hot Temperature; Humans; Immunoglobulin G; Indomethacin; Iodine Radioisotopes; L-Lactate Dehydrogenase; Methylprednisolone; Neutrophils; Peptide Hydrolases; Probenecid; Protein Denaturation; Sulfur Radioisotopes; Synovial Fluid; Triamcinolone Acetonide; Vinblastine | 1974 |
The binding of urate to plasma proteins.
Topics: Allopurinol; Aspirin; Binding Sites; Blood Proteins; Colchicine; Dialysis; Evaluation Studies as Topic; Gout; Humans; Hydrogen-Ion Concentration; Indomethacin; Kidney Diseases; Kinetics; Methods; Osmolar Concentration; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Solubility; Sulfinpyrazone; Temperature; Time Factors; Uric Acid | 1974 |
[Gout from the view of a special hospital for rheumatic patients].
Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Complications; Diagnosis, Differential; Diagnostic Errors; Gout; Heart Diseases; Hospitals, Special; Humans; Indomethacin; Kidney Diseases; Middle Aged; Obesity; Phenylbutazone; Probenecid; Prognosis; Radiography; Rheumatic Diseases; Sulfinpyrazone; Time Factors; Uric Acid; Uricosuric Agents | 1971 |
[Gout in dermatology].
Topics: Adolescent; Aged; Colchicine; Diagnosis, Differential; Gout; Humans; Indomethacin; Joint Diseases; Male; Middle Aged; Osteoporosis; Phenylbutazone; Probenecid; Radiography; Skin Diseases; Skin Ulcer; Sulfinpyrazone; Toes | 1969 |
Effect of drugs on the binding of urate to human albumin.
Topics: Allopurinol; Aspirin; Colchicine; Humans; Indomethacin; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Sulfinpyrazone; Uric Acid | 1970 |
Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro.
Topics: Allopurinol; Anti-Inflammatory Agents; Aspirin; Binding Sites; Caprylates; Colchicine; Dialysis; Fluorescence; Humans; In Vitro Techniques; Indomethacin; Mefenamic Acid; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Sodium Salicylate; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1970 |
Comparative effects of salicylic acid, phenylbutazone, probenecid and other anions on the metabolism, distribution and excretion of indomethacin by rats.
Topics: Acetates; Administration, Oral; Animals; Bile; Carbon Isotopes; Chlorogenic Acid; Chromatography, DEAE-Cellulose; Feces; Indoleacetic Acids; Indomethacin; Injections, Intravenous; Kidney; Kinetics; Liver; Male; Metabolism; Phenylbutazone; Probenecid; Rats; Salicylates | 1970 |
Etiology and treatment of gout--modern concepts.
Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indomethacin; Joint Diseases; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Proteinuria; Purines; Radiography; Salicylates; Steroids; Sulfinpyrazone; Uric Acid | 1968 |
[Allopurinol in the treatment of gout].
Topics: Adult; Allopurinol; Gout; Humans; Indomethacin; Male; Middle Aged; Probenecid; Uric Acid | 1968 |
An extended study of indomethacin. II. Clinical therapy.
Topics: Adolescent; Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Child; Female; Gout; Humans; Indomethacin; Male; Phenylbutazone; Probenecid; Psoriasis; Spondylitis, Ankylosing | 1966 |
Management of gout and hyperuricemia.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Gout; Humans; Indomethacin; Kidney; Patient Education as Topic; Phenylbutazone; Phosphoribosyl Pyrophosphate; Probenecid; Purines; Uric Acid; Uricosuric Agents | 1984 |
Renal disposition of ceftazidime illustrated by interferences by probenecid, furosemide, and indomethacin in rabbits.
Topics: Animals; Blood Proteins; Ceftazidime; Diffusion; Drug Interactions; Furosemide; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Probenecid; Protein Binding; Rabbits | 1984 |
Is prostaglandin a mediator for the inhibitory action of histamine, hydrocortisone, and isoproterenol?
Topics: Angiotensins; Bradykinin; Cell Adhesion; Cell Separation; Cyclooxygenase Inhibitors; Histamine; Humans; Hydrocortisone; Incubators; Indomethacin; Isoproterenol; Mitogens; Phytohemagglutinins; Probenecid; Prostaglandins E | 1980 |
Practical therapeutics treatment of gout.
Topics: Colchicine; Female; Gout; Humans; Indomethacin; Male; Phenylbutazone; Probenecid; Sulfinpyrazone | 1981 |
Probenecid-clofibrate interaction.
Topics: Adolescent; Adult; Clofibrate; Drug Interactions; Female; Glucuronates; Humans; Indomethacin; Metabolic Clearance Rate; Probenecid; Protein Binding | 1981 |
Probenecid inhibits the glucuronidation of indomethacin and O-desmethylindomethacin in humans. A pilot experiment.
Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Indomethacin; Kidney; Male; Middle Aged; Pilot Projects; Probenecid | 1994 |
Determination of indomethacin, its metabolites and their glucuronides in human plasma and urine by means of direct gradient high-performance liquid chromatographic analysis. Preliminary pharmacokinetics and effect of probenecid.
Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Hydrogen-Ion Concentration; Indoleacetic Acids; Indomethacin; Isomerism; Male; Middle Aged; Pilot Projects; Probenecid | 1993 |
Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Drug Resistance, Multiple; Endothelium, Vascular; Fluorescein; Humans; Indomethacin; Kinetics; Microcirculation; Multidrug Resistance-Associated Proteins; Polymerase Chain Reaction; Probenecid; RNA; Tumor Cells, Cultured | 1998 |
Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Clofibrate; Flufenamic Acid; Furosemide; Glucuronates; Glucuronidase; Indomethacin; Mass Spectrometry; Molecular Structure; Probenecid; Tolmetin | 1998 |
Determination of folate transport pathways in cultured rat proximal tubule cells.
Topics: Animals; Anion Transport Proteins; Aspirin; Biological Transport; Carrier Proteins; Cells, Cultured; Folate Receptors, GPI-Anchored; Folic Acid; Glomerular Filtration Rate; Indomethacin; Kidney Tubules, Proximal; Male; Membrane Proteins; Membrane Transport Proteins; Probenecid; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Reduced Folate Carrier Protein; Renal Agents; Tetrahydrofolates | 1998 |
Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells.
Topics: Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bile Ducts, Intrahepatic; Biological Transport; Blotting, Northern; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Epithelial Cells; Fluoresceins; Indomethacin; Indoprofen; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Sprague-Dawley; Rifamycins; RNA; Tumor Cells, Cultured | 1999 |
The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Indomethacin; Liver Neoplasms, Experimental; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1999 |
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export.
Topics: Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Benzbromarone; Biological Transport, Active; Carrier Proteins; Dose-Response Relationship, Drug; Glutathione; Humans; Indomethacin; Probenecid; Sulfinpyrazone; Tumor Cells, Cultured; Uricosuric Agents; Vinblastine | 2000 |
Budesonide reduces multidrug resistance-associated protein 1 expression in an airway epithelial cell line (Calu-1).
Topics: Blotting, Western; Bronchodilator Agents; Budesonide; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation; Humans; Indomethacin; Lung; Multidrug Resistance-Associated Proteins; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Verapamil; Vincristine | 2002 |
Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells.
Topics: Biological Transport, Active; Caco-2 Cells; Diffusion; Diuretics; Dose-Response Relationship, Drug; Furosemide; Humans; Indomethacin; Probenecid | 2002 |
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil | 2002 |
Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Catechin; Drug Stability; HT29 Cells; Humans; Hydrogen Peroxide; Indomethacin; Oxidation-Reduction; Probenecid; Temperature; Tritium; Vinblastine | 2002 |
GOUT.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colchicine; Diagnosis, Differential; Diet; Diet Therapy; Drug Therapy; Epidemiology; Genetics, Medical; Gout; Humans; Indomethacin; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Uric Acid; Urine | 1964 |
[SEVERE GOUT IN A YOUNG MAN. TREATMENT WITH BENEMID AND INDOMETHACIN].
Topics: Gout; Humans; Indoles; Indomethacin; Male; Probenecid; Uricosuric Agents | 1965 |
Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.
Topics: Adenocarcinoma; Animals; Biological Transport, Active; Brain; Cattle; Cells, Cultured; Cyclooxygenase Inhibitors; Dinitrophenols; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Fluoresceins; GABA Agents; Humans; Indomethacin; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Pancreatic Neoplasms; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotenone; Temperature; Tritium; Uncoupling Agents; Uricosuric Agents; Valproic Acid | 2004 |
Characterization of secretory intestinal transport of phenolsulfonphthalein.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Chromatography, High Pressure Liquid; Indomethacin; Intestinal Mucosa; Intestines; Kinetics; Male; p-Aminohippuric Acid; Permeability; Phenolsulfonphthalein; Probenecid; Rats; Rats, Wistar | 2005 |
Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluoresceins; Fluorescent Dyes; Indomethacin; Mice; Probenecid; Propionates; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; T-Lymphocytes; Thymoma | 2005 |
In vivo and in vitro modulation of MDR molecules in murine thymocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Flow Cytometry; Fluorescent Antibody Technique; Genes, MDR; Indomethacin; Male; Mice; Mice, Inbred C3H; Multidrug Resistance-Associated Proteins; Probenecid; Propionates; Quinolines; Renal Agents; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; T-Lymphocytes; Thymus Gland | 2006 |
Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Dogs; Humans; Indomethacin; N-Methyl-3,4-methylenedioxyamphetamine; Probenecid; Progesterone; Propionates; Quinolines; Rhodamine 123; Ritonavir; Verapamil | 2006 |
Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Erythrocyte Membrane; Glutathione; Indomethacin; Methotrexate; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Transport Vesicles; Valproic Acid | 2006 |
Progesterone inhibits folic acid transport in human trophoblasts.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; ATP-Binding Cassette Transporters; Estradiol; Folic Acid; Humans; Indoles; Indomethacin; Kinetics; p-Aminohippuric Acid; Probenecid; Progesterone; Trophoblasts; Verapamil | 2007 |
Evaluation of substrate and inhibitor properties of a novel MDR modulator H17 towards transmembrane efflux pumps.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzyl Compounds; Cell Membrane Permeability; Drug Combinations; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Indomethacin; Intestinal Absorption; Male; Models, Biological; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Wistar | 2009 |
Evaluation of the selected barrier properties of retinal pigment epithelial cell line ARPE-19 for an in-vitro blood-brain barrier model.
Topics: Animal Use Alternatives; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Caco-2 Cells; Cell Line; Cell Survival; Electric Impedance; Endothelium, Vascular; Humans; Indomethacin; Membrane Proteins; Models, Biological; Multidrug Resistance-Associated Proteins; Occludin; Phosphoproteins; Probenecid; Retinal Pigment Epithelium; Swine; Zonula Occludens-1 Protein | 2008 |
Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Benzothiazoles; Biological Transport; Captopril; Cells, Cultured; Dogs; Enalapril; Indomethacin; Inhibitory Concentration 50; Organic Anion Transporters; Organic Cation Transport Proteins; Phenylbutazone; Probenecid; Pyridines; Salicylates; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 2011 |
A one-pot synthesis of tetrazolones from acid chlorides: understanding functional group compatibility, and application to the late-stage functionalization of marketed drugs.
Topics: Aspirin; Azides; Benzimidazoles; Benzoates; Bexarotene; Carboxylic Acids; Chemistry Techniques, Synthetic; Chlorides; Indomethacin; Niacin; Probenecid; Silanes; Telmisartan; Tetrahydronaphthalenes; Tetrazoles | 2016 |