Page last updated: 2024-08-16

probenecid and haloperidol

probenecid has been researched along with haloperidol in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (56.41)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (20.51)	29.6817
2010's	8 (20.51)	24.3611
2020's	1 (2.56)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Scally, MC; Ulus, I; Wurtman, RJ	1
Dedek, J; Gomeni, R; Korf, J	1
Bacopoulos, NG; Heninger, GR; Roth, RH	1
Korf, J; Westerink, BH	3
Korf, J; Sebens, JB	1
Hefti, F	1
Carter, CJ; Pycock, CJ	1
Adams, F; Becker, JB; Robinson, TE	1
Djordjević, N; Jernej, B; Levanat, S; Manev, H; Pericić, D; Vujić, D	1
Kharouba, SN; Kim, C; Speisky, MB	1
Kikkert, RJ; Westerink, BH	1
Chase, TN	3
Gessa, GL; Perez-Cruet, J; Stern, S; Tagliamonte, A; Tagliamonte, P	1
Werdinius, B	1
Bartholini, G; Keller, HH; Pletscher, A	1
Dresse, A; Gérardy, J; Quinaux, N	1
Bowers, MB; Gold, BI; Roth, RH	1
Huot, S; Palfreyman, MG; Wagner, J	1
Emanuelsson, C; Erhardt, S; Geyer, M; Schwieler, L	1

Reviews

2 review(s) available for probenecid and haloperidol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced extrapyramidal disorders. Research publications - Association for Research in Nervous and Mental Disease, 1972, Volume: 50 Topics: Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Benztropine; Dihydroxyphenylalanine; Dopamine; Drug-Related Side Effects and Adverse Reactions; Extrapyramidal Tracts; Haloperidol; Humans; Methyltyrosines; Movement Disorders; Phenothiazines; Phenylacetates; Probenecid; Reserpine; Synaptic Transmission; Tetrabenazine; Tranquilizing Agents; Trihexyphenidyl	1972

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Drug-induced extrapyramidal disorders.

Research publications - Association for Research in Nervous and Mental Disease, 1972, Volume: 50

Topics: Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Benztropine; Dihydroxyphenylalanine; Dopamine; Drug-Related Side Effects and Adverse Reactions; Extrapyramidal Tracts; Haloperidol; Humans; Methyltyrosines; Movement Disorders; Phenothiazines; Phenylacetates; Probenecid; Reserpine; Synaptic Transmission; Tetrabenazine; Tranquilizing Agents; Trihexyphenidyl

1972

Other Studies

37 other study(ies) available for probenecid and haloperidol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats. Journal of neural transmission, 1977, Volume: 41, Issue:1 Topics: Animals; Brain Chemistry; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Homovanillic Acid; Male; Probenecid; Rats; Tyrosine; Tyrosine 3-Monooxygenase	1977
A model of dopamine metabolism in rat brain, assessed by the influence of drugs [proceedings]. Archives internationales de physiologie et de biochimie, 1979, Volume: 87, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Haloperidol; Homovanillic Acid; Pargyline; Probenecid; Rats	1979
Effects of haloperidol and probenecid on plasma and CSF dopamine metabolites in the rhesus monkey (Macacca mulatta). Life sciences, 1978, Oct-30, Volume: 23, Issue:17-18 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Drug Interactions; Haloperidol; Haplorhini; Homovanillic Acid; Macaca mulatta; Male; Probenecid; Starvation; Time Factors	1978
Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain. European journal of pharmacology, 1975, Volume: 33, Issue:1 Topics: Aminooxyacetic Acid; Animals; Atropine; Brain; Brain Chemistry; Clozapine; Corpus Striatum; Fenclonine; Haloperidol; Homovanillic Acid; Limbic System; Male; Morphine; Oxotremorine; Phenylacetates; Physostigmine; Pimozide; Probenecid; Rats; Substantia Nigra; Trihexyphenidyl	1975
Cyclic AMP in cerebrospinal fluid: accumulaiton following probenecid and biogenic amines. Experimental neurology, 1975, Volume: 46, Issue:2 Topics: Animals; Biogenic Amines; Catecholamines; Cyclic AMP; Dopamine; Haloperidol; Histamine; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Isoproterenol; Levodopa; Male; Norepinephrine; Probenecid; Rabbits; Stimulation, Chemical	1975
A simple, sensitive method for measuring 3,4-dihydroxyphenylacetic acid and homovanillic acid in rat brain tissue using high-performance liquid chromatography with electrochemical detection. Life sciences, 1979, Aug-27, Volume: 25, Issue:9 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Haloperidol; Homovanillic Acid; Male; Phenylacetates; Probenecid; Rats; Tissue Distribution	1979
Potentiation of haloperidol-induced catalepsy by dopamine agonists: possible involvement of central 5-hydroxytryptamine. Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:4 Topics: Animals; Apomorphine; Brain; Catalepsy; Dextroamphetamine; Dopamine; Drug Interactions; Haloperidol; Humans; Hydroxyindoleacetic Acid; Male; Probenecid; Rats; Serotonin	1979
Acidic dopamine metabolites in cortical areas of the rat brain: localization and effects of drug. Brain research, 1976, Aug-27, Volume: 113, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Homovanillic Acid; Male; Morphine; Olfactory Bulb; Oxotremorine; Phenylacetates; Probenecid; Rats; Sulpiride; Thioridazine	1976
Comparison of effects of drugs on dopamine metabolism in the substantia nigra and the corpus striatum of rat brain. European journal of pharmacology, 1976, Volume: 40, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain Chemistry; Chloral Hydrate; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Morphine; Oxotremorine; Pargyline; Phenylacetates; Probenecid; Promethazine; Rats; Receptors, Dopamine; Substantia Nigra	1976
Intraventricular microdialysis: a new method for determining monoamine metabolite concentrations in the cerebrospinal fluid of freely moving rats. Journal of neuroscience methods, 1988, Volume: 24, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Medulla; Animals; Cerebral Ventricles; Dialysis; Dopamine; Female; Haloperidol; Homovanillic Acid; Hydroxydopamines; Hydroxyindoleacetic Acid; Oxidopamine; Phenylacetates; Probenecid; Rats; Substantia Nigra	1988
Effect of dihydroergosine (DHESN) on the serotoninergic system and behaviour: is DHESN a new antidepressive agent? Psychopharmacology, 1986, Volume: 90, Issue:1 Topics: Animals; Antidepressive Agents; Blood Platelets; Cyproheptadine; Ergotamines; Fenclonine; Haloperidol; Male; Monoamine Oxidase Inhibitors; Motor Activity; Probenecid; Rats; Rats, Inbred Strains; Serotonin	1986
Rapid and sensitive method for measuring norepinephrine, dopamine, 5-hydroxytryptamine and their major metabolites in rat brain by high-performance liquid chromatography. Differential effect of probenecid, haloperidol and yohimbine on the concentrations o Journal of chromatography, 1987, Jan-16, Volume: 386 Topics: Animals; Biogenic Amines; Biotransformation; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Haloperidol; Hydrolysis; Norepinephrine; Probenecid; Rats; Rats, Inbred Strains; Serotonin; Yohimbine	1987
Effect of various centrally acting drugs on the efflux of dopamine metabolites from the rat brain. Journal of neurochemistry, 1986, Volume: 46, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Biological Transport, Active; Brain; Brain Stem; Central Nervous System Agents; Chloral Hydrate; Chlorpromazine; Corpus Striatum; Dopamine; Frontal Lobe; Haloperidol; Homovanillic Acid; Kainic Acid; Male; Olfactory Bulb; Oxotremorine; Pargyline; Phenylacetates; Probenecid; Rats	1986
Central monoamine metabolism in man. Effect of putative dopamine receptor agonists and antagonists. Archives of neurology, 1973, Volume: 29, Issue:5 Topics: Adult; Basal Ganglia Diseases; Brain; Central Nervous System Diseases; Dopamine; Haloperidol; Homovanillic Acid; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Muscular Diseases; Parkinson Disease; Piperazines; Probenecid; Receptors, Drug; Serotonin	1973
Effect of psychotropic drugs on tryptophan concentration in the rat brain. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 177, Issue:3 Topics: Alkaloids; Animals; Apomorphine; Aporphines; Body Temperature; Brain Chemistry; Butyrates; Chlorpromazine; Cold Temperature; Cyclic AMP; Dextroamphetamine; Fenclonine; Fenfluramine; Haloperidol; Hot Temperature; Hydroxybutyrates; Hydroxyindoleacetic Acid; Lithium; Male; Methyltyrosines; Morphine; Nucleosides; Phenelzine; Phenmetrazine; Probenecid; Rats; Reserpine; Serotonin; Tryptophan; Tyrosine	1971
Effect of probenecid on the level of homovanillic acid in the corpus striatum. The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:8 Topics: Animals; Basal Ganglia; Dopamine; Female; Fluorometry; Haloperidol; Male; Phenylacetates; Probenecid; Rats; Reserpine	1966
Clinical studies of dopaminergic mechanisms. Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0 Topics: Antiparkinson Agents; Dioxoles; Dopamine; Drug Evaluation; Haloperidol; Homovanillic Acid; Humans; Levodopa; Parkinson Disease; Piperidines; Probenecid; Pyrimidines	1974
Spontaneous and drug-induced changes of cerebral dopamine turnover during postnatal development of rats. Brain research, 1973, Dec-21, Volume: 64 Topics: Animals; Apomorphine; Brain; Corpus Striatum; Dopamine; Feedback; Female; Haloperidol; Homovanillic Acid; Male; Norepinephrine; Phenylacetates; Probenecid; Rats; Receptors, Adrenergic	1973
[Determination of noradrenaline, of dopamine and dihydroxyphenylacetic acid in certain nuclei of rat brain]. Experientia, 1971, Jan-15, Volume: 27, Issue:1 Topics: Animals; Ascorbic Acid; Catecholamines; Caudate Nucleus; Chromatography, Thin Layer; Dihydroxyphenylalanine; Dopamine; Female; Fluorometry; Haloperidol; Hypothalamus; Male; Norepinephrine; Phenylacetates; Probenecid; Rats; Reserpine; Tranylcypromine	1971
CSF GABA in psychotic disorders. Psychopharmacology, 1980, Volume: 70, Issue:3 Topics: Adolescent; Adult; Female; gamma-Aminobutyric Acid; Haloperidol; Homovanillic Acid; Humans; Male; Middle Aged; Probenecid; Psychotic Disorders	1980
Value of monoamine metabolite determinations in CSF as an index of their concentrations in rat brain following various pharmacological manipulations. Journal of pharmacological methods, 1982, Volume: 8, Issue:3 Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Haloperidol; Indoles; Levodopa; Male; Probenecid; Rats; Rats, Inbred Strains; Time Factors	1982
Endogenous kynurenic acid disrupts prepulse inhibition. Biological psychiatry, 2004, Aug-15, Volume: 56, Issue:4 Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Butyrates; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Haloperidol; Kynurenic Acid; Kynurenine; Male; Neural Inhibition; Probenecid; Rats; Reflex, Startle	2004