Page last updated: 2024-08-16

probenecid and digoxin

probenecid has been researched along with digoxin in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (23.68)	18.7374
1990's	5 (13.16)	18.2507
2000's	13 (34.21)	29.6817
2010's	11 (28.95)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hashimoto, Y; Ibaramoto, K; Inui, KI; Masuda, S; Saito, H; Takeuchi, A	1
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Abe, T; Endou, H; Kusuhara, H; Meier, PJ; Sekine, T; Shitara, Y; Sugiyama, D; Sugiyama, Y; Suzuki, H	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Ebner, T; Ishiguro, N; Kishimoto, W; Schaefer, O; Shimizu, H	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bass, NH; Fällström, SP; Lundborg, P	1
Erttmann, RR	1
Hedman, A	1
Angelin, B; Arvidsson, A; Dahlqvist, R; Hedman, A	1
Cacini, W; Wernke, MJ	1
Harnish, PP; Samuel, K	1
Baar, S; Jackson, D; Pollock, A; Sevitt, S; Stone, P	1
Braun, W; Damm, KH; Heckert, H	1
Damm, KH; Woermann, C	1
Kupferberg, HJ; Schankl, LS	1
Blye, E; Cortell, S; Lorch, J	1
Gibbs, JE; Jayabalan, P; Thomas, SA	1
Bourasset, F; Cisternino, S; Scherrmann, JM; Temsamani, J	1
SILBERSTEIN, EB	1
Almeida, I; Ely, D; Podila, L; Taub, ME	1
Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Liu, PQ; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW	1
Hao, H; He, H; Li, X; Wang, G; Wang, R; Wang, W; Xie, H; Xu, M	1

Reviews

3 review(s) available for probenecid and digoxin

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Extracorporeal therapy in the treatment of intoxication. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1984, Volume: 3, Issue:5 Topics: Biological Transport; Digoxin; Hemoperfusion; Humans; Hydrogen-Ion Concentration; Ions; Lipid Metabolism; Peritoneal Dialysis; Poisoning; Probenecid; Protein Binding; Renal Dialysis; Solubility; Tissue Distribution	1984

Other Studies

35 other study(ies) available for probenecid and digoxin

Article	Year
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Molecular pharmacology, 1999, Volume: 55, Issue:4 Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Kidney; Male; Membrane Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Oocytes; Organic Anion Transporters; Rats; Rats, Wistar; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tissue Distribution; Transfection; Xenopus laevis	1999
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1 Topics: Animals; Anion Transport Proteins; Blood-Brain Barrier; Brain; Carrier Proteins; Digoxin; Enzyme Inhibitors; Estradiol; Glucuronates; Male; Microinjections; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Taurocholic Acid	2001
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Base Sequence; Dipeptidyl-Peptidase IV Inhibitors; DNA Primers; Drug Evaluation, Preclinical; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Linagliptin; LLC-PK1 Cells; Purines; Quinazolines; Swine	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Digoxin-induced arrest of the cerebrospinal fluid circulation in the infant rat: implications for medical treatment of hydrocephalus during early postnatal life. Pediatric research, 1979, Volume: 13, Issue:1 Topics: Animals; Brain Chemistry; Cerebrospinal Fluid; Digoxin; Humans; Hydrocephalus; Hydroxyindoleacetic Acid; Infant; Intracranial Pressure; Probenecid; Rats; Time Factors	1979
Kinetics and inotropic action of probenecid in guinea-pig heart in vitro. Experientia, 1978, Dec-15, Volume: 34, Issue:12 Topics: Animals; Digoxin; Drug Interactions; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Kinetics; Myocardial Contraction; Myocardium; Probenecid	1978
Inhibition by basic drugs of digoxin secretion into human bile. European journal of clinical pharmacology, 1992, Volume: 42, Issue:4 Topics: Bile; Chromatography, High Pressure Liquid; Digoxin; Drug Interactions; Humans; Probenecid; Quinidine; Quinine; Radioimmunoassay; Spironolactone; Verapamil	1992
No effect of probenecid on the renal and biliary clearances of digoxin in man. British journal of clinical pharmacology, 1991, Volume: 32, Issue:1 Topics: Administration, Oral; Adult; Biliary Tract; Digoxin; Half-Life; Humans; Infusions, Intravenous; Kidney; Male; Metabolic Clearance Rate; Probenecid	1991
Concentrative uptake of digoxin by slices of chicken renal cortex. Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4 Topics: Animals; Chickens; Digitoxin; Digoxigenin; Digoxin; Female; Hexoses; Kidney Cortex; Kinetics; Ouabain; Potassium; Probenecid; Quinine; Sodium Cyanide; Spironolactone	1990
Pharmacologic manipulation of the flushing action of cerebrospinal fluid. Effect on CSF diatrizoate levels. Investigative radiology, 1988, Volume: 23, Issue:12 Topics: Acetazolamide; Aminophylline; Animals; Bucladesine; Carbachol; Cerebrospinal Fluid; Dexamethasone; Diatrizoate; Digoxin; Furosemide; Male; Premedication; Probenecid; Rats; Rats, Inbred Strains; Ritodrine; Salicylates; Salicylic Acid	1988
Acute Heinz-body anaemia in burned patients. Lancet (London, England), 1973, Sep-01, Volume: 2, Issue:7827 Topics: Adult; Ampicillin; Anemia, Hemolytic; Aspirin; Burns; Carbenicillin; Cloxacillin; Digoxin; Erythrocytes; Female; Gentamicins; Glucosephosphate Dehydrogenase; Heinz Bodies; Humans; Infant; Male; Probenecid; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections	1973
[The effect of probenecid on the distribution of digitoxin, digoxin and ouabain in the mouse]. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 277, Issue:3 Topics: Animals; Chromatography, Thin Layer; Digitoxin; Digoxin; Heart; Liver; Mice; Muscles; Myocardium; Ouabain; Probenecid; Tritium	1973
The effect of probenecid on the in vitro absorption of cardiac glycosides. European journal of pharmacology, 1974, Volume: 28, Issue:1 Topics: Animals; Biological Transport; Body Water; Calcium; Cardiac Glycosides; Chromatography, Thin Layer; Digitoxin; Digoxin; Ethacrynic Acid; Furosemide; Glucose; Hydrochlorothiazide; In Vitro Techniques; Intestinal Absorption; Jejunum; Mersalyl; Mice; Mice, Inbred Strains; Osmolar Concentration; Ouabain; Oxygen Consumption; Potassium; Probenecid; Sodium; Tritium	1974
Biliary secretion of ouabain-3H and its uptake by liver slices in the rat. The American journal of physiology, 1968, Volume: 214, Issue:5 Topics: Aminohippuric Acids; Animals; Bile; Biological Transport, Active; Chromatography, Thin Layer; Digitoxin; Digoxin; Glycosides; Injections, Intravenous; Liver; Liver Extracts; Male; Organ Size; Ouabain; Parasympatholytics; Plants, Medicinal; Probenecid; Procainamide; Rats; Tritium	1968
Mechanisms by which 2',3'-dideoxyinosine (ddI) crosses the guinea-pig CNS barriers; relevance to HIV therapy. Journal of neurochemistry, 2003, Volume: 84, Issue:4 Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anti-HIV Agents; Binding Sites; Binding, Competitive; Blood-Brain Barrier; Brain; Brain Chemistry; Capillary Permeability; Carbon Radioisotopes; Central Nervous System; Choroid Plexus; Chromatography, High Pressure Liquid; Didanosine; Digoxin; Guinea Pigs; Mannitol; Nucleoside Transport Proteins; Perfusion; Probenecid; Reverse Transcriptase Inhibitors; Tritium	2003
Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier. Journal of neurochemistry, 2003, Volume: 86, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Digoxin; Enzyme Inhibitors; Glucose Transporter Type 1; Male; Metabolic Clearance Rate; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Morphine Derivatives; Multidrug Resistance-Associated Proteins; Perfusion; Probenecid; Uricosuric Agents	2003
ERYSIPELOTHRIX ENDOCARDITIS: REPORT OF A CASE WITH CEREBRAL MANIFESTATIONS. JAMA, 1965, Mar-08, Volume: 191 Topics: Brain Diseases; Chloramphenicol; Chlorothiazide; Digoxin; Diuretics; Drug Therapy; Endocarditis; Endocarditis, Bacterial; Erysipelothrix; Heart Failure; Heart Valve Diseases; Humans; Methicillin; Organomercury Compounds; Penicillin V; Penicillins; Probenecid; Sepsis	1965
Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:11 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Caco-2 Cells; Cell Line; Cell Membrane Permeability; Cell Polarity; Colchicine; Dexamethasone; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Hydrocortisone; Paclitaxel; Probenecid; Time Factors; Transfection; Vinblastine	2005
Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge. Current drug metabolism, 2007, Volume: 8, Issue:4 Topics: Abietanes; Adenosine Triphosphate; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Digoxin; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Probenecid; Propionates; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Temperature; Transfection; Verapamil	2007
Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether. Journal of photochemistry and photobiology. B, Biology, 2008, Mar-28, Volume: 90, Issue:3 Topics: Animals; Biliary Tract; Blood Proteins; Deuteroporphyrins; Digoxin; Enzyme Inhibitors; Feces; Humans; Indicators and Reagents; Infusion Pumps; Photosensitizing Agents; Probenecid; Protoporphyrins; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Time Factors; Tissue Distribution; Uricosuric Agents	2008