Page last updated: 2024-08-16

probenecid and cimetidine

probenecid has been researched along with cimetidine in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (9.09)	18.7374
1990's	10 (15.15)	18.2507
2000's	28 (42.42)	29.6817
2010's	20 (30.30)	24.3611
2020's	2 (3.03)	2.80

Authors

Authors	Studies
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Cha, SH; Endou, H; Hosoyamada, M; Jung, KY; Kim, DK; Narikawa, S; Sekine, T; Takeda, M; Tojo, A; Yoo, BS	1
Endou, H; Kusuhara, H; Nagata, Y; Sugiyama, Y	1
Deguchi, T; Hosoya, K; Kang, YS; Mori, S; Ohtsuki, S; Takanaga, H; Terasaki, T	1
Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T	1
Endou, H; Enomoto, A; Huang, XL; Khamdang, S; Narikawa, S; Noshiro, R; Piyachaturawat, P; Shimoda, M; Takeda, M	1
Chang, TK; Ensom, MH; Kiang, TK	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bentur, Y; Cheung, D; Klein, J; Koren, G; Moselhy, G	1
Stein, GE	1
Boyd, RA; Giacomini, KM; Gisclon, LG; Williams, RL	1
Kunnemann, ME; McKinney, TD	1
Champion, GD; Day, RO; Graham, GG; Lee, E	1
McKinney, TD; Speeg, KV	1
Herbert, BH; Nelson, JA; Santos, G	1
Cacini, W; Grund, VR; Keller, MB	1
Chiba, K; Hirano, T; Iwata, K; Miyazaki, S; Nakajima, Y; Oda, M; Sasaya, M; Takada, M	1
Aiba, T; Koizumi, T; Sakurai, Y; Tsukada, S	1
Day, RO; Geisslinger, G; Paull, P; Williams, KM	1
Inui, K; Nakamura, T; Takano, M; Yasuhara, M	1
Foote, EF; Halstenson, CE	1
Boom, SP; Meyer, I; Russel, FG; Wouterse, AC	1
Hashiguchi, M; Kasanuki, H; Rikihisa, T; Shiga, T; Urae, A	1
Hanada, K; Kato, T; Kinami, J; Ogata, H; Takubo, T	1
Gerk, PM; McNamara, PJ; Moscow, JA; Oo, CY; Paxton, EW	1
Barrett, J; Cihlar, T; Hill, G; Ho, ES; Liu, B; Oo, C; Prior, K; Ward, P; Wiltshire, H	1
Bidault, R; De Bony, F; On, NT; Posner, J; Rolan, P; Tod, M	1
Cox, S; Evans, AM; Nation, RL; Wang, J	1
Endou, H; Hirono, S; Kusuhara, H; Nagata, Y; Sugiyama, Y	1
Sugawara, K; Tateishi, T; Uno, T; Yasui-Furukori, N	1
Braun, EJ; Dudas, PL; Pelis, RM; Renfro, JL	1
Borgå, O; Cheng, YF; Nilsson, D; Strid, S; Wemer, J	1
Hu, J; Liu, H; Liu, X; Wang, G; Xie, L	1
Abe, F; Hasegawa, T; Kato, M; Kimura, M; Kurono, S; Nadai, M; Saito, H; Yoshizumi, H	1
Aoki, T; Hashimoto, T; Kamimura, H; Minematsu, T; Usui, T	1
Horita, S; Inoue, K; Kondo, T; Kusuhara, H; Maeda, K; Matsushima, S; Nakayama, H; Ohta, KY; Sugiyama, Y; Yuasa, H	1
Chakilam, AR; Jayaraj, A; Taft, DR; Tamhane, M; Thakkar, V	1
Adams, WJ; Balogh, LM; Brayman, TG; Cox, SR; Kumar, V; Lai, Y; Sampson, KE; Stevens, JC	1
Davey, AK; Hong, T; Jin, Y; Jiping, W; Lei, C; Qian, W; Ruijuan, X; Xuefen, Y; Xueying, Z; Yanxiao, C	1
Anzai, N; Eraly, SA; Gerasimova, M; Nagle, M; Nigam, SK; Rao, SR; Rieg, T; Rose, M; Sharma, K; Smith, T; Vallon, V	1
Corrigan, B; El-Kattan, A; Feng, B; Hurst, S; Lockwood, P; Lu, Y; Rotter, CJ; Varma, MV	1
Chen, X; Li, X; Xie, C; Zhang, Y; Zhong, D; Zhong, K	1
Chang, LW; Chang, YT; Chen, XY; Dai, XJ; Tang, YB; Tsai, CY; Wang, T; Yang, Y; Zhang, YF; Zhong, DF	1
Jung, JA; Parvez, MM; Shin, HJ; Shin, JG	1
Atiee, GJ; Dishy, V; He, L; Hsu, C; Tachibana, M; Warren, V; Yamamura, N; Zahir, H	1
Bader, K; Ebner, T; Fromm, MF; Giessmann, T; Hauel, E; Hohl, K; Ishiguro, N; Jambrecina, A; Mikus, G; Müller, F; Schmidt-Gerets, S; Sharma, A; Stopfer, P; Taub, ME; Wiebe, ST	1
Deutsch, B; Fromm, MF; Gessner, A; Hohl, K; Keller, S; Müller, F; Schmidt-Gerets, S; Schuler-Metz, A; Stopfer, P	1

Reviews

5 review(s) available for probenecid and cimetidine

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions with fluoroquinolones. The American journal of medicine, 1991, Dec-30, Volume: 91, Issue:6A Topics: 4-Quinolones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Cyclosporine; Drug Interactions; Humans; Metals; Probenecid; Warfarin; Xanthines	1991
Anti-rheumatic drug interactions. Clinics in rheumatic diseases, 1984, Volume: 10, Issue:2 Topics: Adrenergic beta-Antagonists; Allopurinol; Animals; Antacids; Anti-Inflammatory Agents; Anticoagulants; Cimetidine; Diuretics; Drug Combinations; Drug Interactions; Glucocorticoids; Gold; Humans; Hypoglycemic Agents; Penicillamine; Probenecid; Sulfinpyrazone; Vasodilator Agents	1984

Trials

11 trial(s) available for probenecid and cimetidine

Article	Year
The effect of probenecid on the renal elimination of cimetidine. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4 Topics: Adult; Cimetidine; Glomerular Filtration Rate; Half-Life; Humans; Inulin; Kidney; Male; Metabolic Clearance Rate; Models, Biological; Probenecid	1989
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Enzyme Inhibitors; Humans; Kidney; Lidocaine; Male; Probenecid; Reference Values; Uricosuric Agents	2000
The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:1 Topics: Acetamides; Adolescent; Adult; Amoxicillin; Animals; Antiviral Agents; Biological Transport; CHO Cells; Cimetidine; Cricetinae; Cross-Over Studies; Drug Interactions; Female; Humans; Influenza, Human; Kidney; Male; Middle Aged; Neuraminidase; Organic Anion Transport Protein 1; Oseltamivir; p-Aminohippuric Acid; Probenecid; Prodrugs	2002
Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:2 Topics: Acyclovir; Adult; Area Under Curve; Cimetidine; Cross-Over Studies; Drug Interactions; Drug Tolerance; Humans; Male; Probenecid; Valacyclovir; Valine	2002
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics. Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:1 Topics: Adult; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cimetidine; Drug Interactions; Half-Life; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Probenecid; Terfenadine; Uricosuric Agents; Verapamil	2005
Active renal secretion of NXY-059, a novel neuroprotectant, is mediated via an organic acid transporter. Journal of clinical pharmacology, 2007, Volume: 47, Issue:7 Topics: Adult; Benzenesulfonates; Cimetidine; Drug Interactions; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney Function Tests; Male; Middle Aged; Neuroprotective Agents; Organic Anion Transporters; Probenecid	2007
Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). The Journal of pharmacology and experimental therapeutics, 2010, Sep-01, Volume: 334, Issue:3 Topics: Adult; Animals; Anti-Bacterial Agents; Biological Transport, Active; Caco-2 Cells; Cimetidine; Cyclic S-Oxides; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Histamine H2 Antagonists; Humans; Intestinal Absorption; Kidney; Macaca fascicularis; Male; Mice; Mice, Knockout; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Oxazolidinones; Probenecid; Rats; Rats, Sprague-Dawley; Renal Agents	2010
Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers. Drug design, development and therapy, 2016, Volume: 10 Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Area Under Curve; Asian People; Chromatography, Liquid; Cimetidine; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Probenecid; Quinolones; Tandem Mass Spectrometry; Young Adult	2016
Coadministration of probenecid and cimetidine with mirogabalin in healthy subjects: A phase 1, randomized, open-label, drug-drug interaction study. British journal of clinical pharmacology, 2018, Volume: 84, Issue:10 Topics: Administration, Oral; Adult; Area Under Curve; Bridged Bicyclo Compounds; Cimetidine; Cross-Over Studies; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Healthy Volunteers; Herpes Zoster; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neuralgia; Probenecid; Renal Elimination	2018
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine. Clinical pharmacokinetics, 2020, Volume: 59, Issue:12 Topics: Area Under Curve; Cimetidine; Drug Interactions; Humans; Male; Probenecid; Rifampin; Verapamil	2020
N Clinical pharmacology and therapeutics, 2023, Volume: 113, Issue:5 Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Membrane Transport Proteins; Probenecid; Rifampin; Verapamil	2023

Other Studies

50 other study(ies) available for probenecid and cimetidine

Article	Year
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Characterization of ochratoxin A transport by human organic anion transporters. Life sciences, 2001, Sep-21, Volume: 69, Issue:18 Topics: Animals; Biological Transport; Cell Line; Humans; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Potassium	2001
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Molecular pharmacology, 2002, Volume: 61, Issue:5 Topics: Animals; Choroid Plexus; Cimetidine; Enzyme Inhibitors; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Penicillins; Rats; Rats, Sprague-Dawley	2002
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:4 Topics: Animals; Blood-Brain Barrier; Cimetidine; Convulsants; Endothelium, Vascular; Enzyme Inhibitors; Homovanillic Acid; Indican; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Rats; Rats, Wistar; Transfection; Tritium; Xenopus laevis	2003
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger	2004
Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. Journal of pharmacological sciences, 2004, Volume: 94, Issue:2 Topics: Animals; Cimetidine; Humans; Organic Anion Transporters; Pravastatin; Rats	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Renal handling of cisplatin: interactions with organic anions and cations in the dog. Clinical and investigative medicine. Medecine clinique et experimentale, 1991, Volume: 14, Issue:5 Topics: Animals; Anions; Blood Proteins; Cations; Cimetidine; Cisplatin; Dogs; Glomerular Filtration Rate; Kidney; Kidney Tubules; Metabolic Clearance Rate; Probenecid; Protein Binding; Quinidine; Ranitidine	1991
Cimetidine transport in rabbit renal cortical brush-border membrane vesicles. The American journal of physiology, 1987, Volume: 252, Issue:3 Pt 2 Topics: Animals; Biological Transport, Active; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cimetidine; Female; Hydrogen-Ion Concentration; Kidney Cortex; Microvilli; Osmolar Concentration; Probenecid; Procainamide; Quinidine; Rabbits; Tetraethylammonium Compounds; Valinomycin	1987
Cimetidine and procainamide secretion by proximal tubules in vitro. The American journal of physiology, 1982, Volume: 242, Issue:6 Topics: Absorption; Acecainide; Animals; Carbon Dioxide; Chromatography, High Pressure Liquid; Cimetidine; Guanidines; Hypothermia; Kidney Tubules, Proximal; Kinetics; Ouabain; Probenecid; Procainamide; Quinidine; Rabbits	1982
Mechanisms for the renal secretion of cisplatin. Cancer treatment reports, 1984, Volume: 68, Issue:6 Topics: Animals; Binding, Competitive; Biological Transport, Active; Cimetidine; Cisplatin; In Vitro Techniques; Kidney; Male; Mice; Mice, Inbred AKR; p-Aminohippuric Acid; Platinum; Probenecid; Tetraethylammonium; Tetraethylammonium Compounds	1984
Accumulation of cimetidine by kidney cortex slices. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:2 Topics: Animals; Cimetidine; Dogs; Energy Metabolism; Guanidines; In Vitro Techniques; Kidney Cortex; Male; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Sodium Cyanide; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors	1982
[The uptake of nalidixic acid and enoxacin by rat renal cortical slices in rat]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1995, Volume: 115, Issue:5 Topics: Animals; Cimetidine; Enoxacin; In Vitro Techniques; Ion Transport; Kidney Cortex; Male; Nalidixic Acid; Probenecid; Rats; Rats, Wistar	1995
Effects of probenecid and cimetidine on the renal excretion of 3'-azido-3'-deoxythymidine in rats. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1 Topics: Animals; Biological Transport; Cimetidine; Epithelium; Kidney; Male; Metabolic Clearance Rate; Microvilli; Probenecid; Rats; Rats, Wistar; Zidovudine	1995
Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers. British journal of clinical pharmacology, 1994, Volume: 37, Issue:1 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Interactions; Female; Humans; Male; Piroxicam; Probenecid	1994
In-vivo clearance study of vancomycin in rats. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:11 Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Cimetidine; Kidney; Male; Metabolic Clearance Rate; Probenecid; Quinidine; Rats; Rats, Wistar; Renal Agents; Vancomycin	1996
Effects of probenecid and cimetidine on renal disposition of ofloxacin in rats. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:2 Topics: Animals; Anti-Infective Agents; Anti-Ulcer Agents; Cimetidine; Drug Interactions; Kidney; Male; Metabolic Clearance Rate; Ofloxacin; Probenecid; Rats; Rats, Sprague-Dawley; Renal Agents	1998
A physiologically based kidney model for the renal clearance of ranitidine and the interaction with cimetidine and probenecid in the dog. Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:3 Topics: Animals; Blood Proteins; Cimetidine; Dogs; Drug Interactions; Histamine H2 Antagonists; Kidney; Kidney Tubules; Male; Mathematical Computing; Models, Biological; Probenecid; Protein Binding; Ranitidine; Uricosuric Agents	1998
Effect of trimethoprim on the renal clearance of lamivudine in rats. The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:3 Topics: Animals; Anti-HIV Agents; Cimetidine; Drug Interactions; Glomerular Filtration Rate; Kidney; Lamivudine; Male; Metabolic Clearance Rate; Probenecid; Quinidine; Rats; Rats, Wistar; Time Factors; Trimethoprim	2000
Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:1 Topics: Actins; Animals; Anion Transport Proteins; Biological Transport, Active; Carrier Proteins; Chromatography, High Pressure Liquid; Cimetidine; Female; Gene Expression; Membrane Proteins; Milk; Nitrofurantoin; Organ Specificity; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Probenecid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Xenobiotics	2001
Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney. Pharmaceutical research, 2004, Volume: 21, Issue:6 Topics: Animals; Antiviral Agents; Cimetidine; Glomerular Filtration Rate; Guanosine; Male; Metabolic Clearance Rate; Nephrons; p-Aminohippuric Acid; Perfusion; Probenecid; Rats; Thioinosine; Tissue Distribution	2004
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9 Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cerebrospinal Fluid; Choroid Plexus; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Male; Models, Molecular; Molecular Structure; Organic Cation Transport Proteins; Penicillin G; Probenecid; Ranitidine; Rats; Rats, Sprague-Dawley; Static Electricity; Tetraethylammonium; Tritium	2004
Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture. The Journal of experimental biology, 2005, Volume: 208, Issue:Pt 22 Topics: Animals; Biological Transport, Active; Bromcresol Green; Carbon Radioisotopes; Chickens; Cimetidine; Cytochalasins; DNA Primers; Electric Impedance; Epithelium; Estrone; Glutarates; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Lithium; Membrane Potentials; Nocodazole; Organic Anion Transporters; Ouabain; p-Aminohippuric Acid; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uric Acid	2005
Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:6 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bile; Biological Transport; Cimetidine; Cyclosporine; Diclofenac; Enzyme Inhibitors; Erythromycin; Liver; Male; Membrane Transport Proteins; Ofloxacin; Probenecid; Rats; Rats, Sprague-Dawley; Uricosuric Agents	2007
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline. Life sciences, 2007, Sep-22, Volume: 81, Issue:15 Topics: Animals; Cimetidine; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Organic Anion Transporters; Organic Cation Transport Proteins; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Substrate Specificity; Tetraethylammonium; Time Factors; Xanthines	2007
Role of organic anion transporters in the pharmacokinetics of zonampanel, an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:8 Topics: Animals; Cell Line; Cimetidine; Excitatory Amino Acid Antagonists; Humans; Imidazoles; LLC-PK1 Cells; Male; Organic Anion Transporters; Probenecid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Swine	2008
The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:3 Topics: Cell Line; Cimetidine; Drug Interactions; Humans; Kidney; Organic Cation Transport Proteins; Probenecid; Terfenadine	2009
Comparative renal excretion of VX-702, a novel p38 MAPK inhibitor, and methotrexate in the perfused rat kidney model. Drug development and industrial pharmacy, 2010, Volume: 36, Issue:3 Topics: Algorithms; Animals; Antirheumatic Agents; Cimetidine; Drug Interactions; Enzyme Inhibitors; Glomerular Filtration Rate; Immunologic Factors; Kidney; Kinetics; Male; Methotrexate; Organic Anion Transporters; Organic Cation Transport Proteins; Osmolar Concentration; p38 Mitogen-Activated Protein Kinases; Perfusion; Phenylurea Compounds; Probenecid; Rats; Rats, Sprague-Dawley; Ultrafiltration	2010
Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats. Life sciences, 2011, Jul-04, Volume: 89, Issue:1-2 Topics: Analysis of Variance; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Chromatography, Liquid; Cimetidine; Guanine; Half-Life; Ion Pumps; Kidney; Male; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Probenecid; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Verapamil	2011
A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. American journal of physiology. Renal physiology, 2012, May-15, Volume: 302, Issue:10 Topics: Animals; Cimetidine; Creatinine; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Probenecid; Uricosuric Agents; Xenopus laevis	2012
Quantitative prediction of renal transporter-mediated clinical drug-drug interactions. Molecular pharmaceutics, 2013, Nov-04, Volume: 10, Issue:11 Topics: Area Under Curve; Cell Line; Cimetidine; Drug Interactions; Humans; Kidney; Mass Spectrometry; Membrane Transport Proteins; Models, Theoretical; Probenecid	2013
Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Cell Line; Cimetidine; Female; HEK293 Cells; Humans; Infusions, Intravenous; Kidney; Male; Middle Aged; Nitroimidazoles; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Probenecid; Protein Binding; Renal Insufficiency; Transfection; Young Adult	2014
Evaluation of Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5 Topics: Aminosalicylic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cimetidine; Drug Interactions; HEK293 Cells; Humans; Ibuprofen; Liver-Specific Organic Anion Transporter 1; Naproxen; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Probenecid; Proton Pump Inhibitors; Quinidine; Rifampin; Verapamil	2017