Page last updated: 2024-08-16

probenecid and cephalexin

probenecid has been researched along with cephalexin in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (42.86)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (25.00)	29.6817
2010's	8 (28.57)	24.3611
2020's	1 (3.57)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Bommareddy, A; Gionfriddo, MR; Heindel, GA; Mukhija, P; Vanwert, AL; Witkowski, S; Wolman, AT	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Prober, CG; Yeager, AS	1
Hallqvist, L; Lindgren, S	1
Kieff, E; Verma, S	1
Aucoin, EJ; Brownlow, WJ; Iglecia-Fernandez, R; Watko, LP	1
Clarke, JT; Kirby, WM; Libke, RD; Regamey, C	1
Davies, JA; Holt, JM	1
Holloway, WJ; Taylor, WA	1
O'Grady, F; Sales, JE; Sutcliffe, M	1
Records, RE	1
Ariyarit, C; Chitwarakorn, A; Panikabutra, K; Saensanoh, C	1
Lim, HB	1
Dominguez-Gil, A; Mariño, EL	1
Bretz, PJ; Hackett, LP; Ilett, KF; Ingle, B	1
Khangura, S; Kissoon, N; Kodeeswaran, T; Wallace, J	1
Campbell, SG; Dalen, D; Eppler, J; Fry, A; Zed, PJ	1
Begg, EJ; Chin, PKL; Everts, R; Moore, GA; Zhang, M	1
Begg, EJ; Begg, R; Chambers, ST; Everts, RJ; Gardiner, SJ; Turnidge, J; Zhang, M	1

Reviews

2 review(s) available for probenecid and cephalexin

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for probenecid and cephalexin

Article	Year
Cefaclor and cefamandole as alternatives to spectinomycin in the treatment of men with uncomplicated gonorrhoea. The British journal of venereal diseases, 1983, Volume: 59, Issue:5 Topics: Cefaclor; Cefamandole; Cephalexin; Drug Therapy, Combination; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillinase; Probenecid; Spectinomycin; Urethritis	1983
Single-dose oral treatment with cefaclor for men with uncomplicated gonococcal urethritis. The Medical journal of Malaysia, 1984, Volume: 39, Issue:4 Topics: Administration, Oral; Adult; Cefaclor; Cephalexin; Clinical Trials as Topic; Drug Therapy, Combination; Gonorrhea; Humans; Male; Middle Aged; Probenecid; Prospective Studies; Urethritis	1984

Other Studies

24 other study(ies) available for probenecid and cephalexin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Biological Transport; Cell Line, Transformed; Humans; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Solubility; Structure-Activity Relationship	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis. The Journal of pediatrics, 1979, Volume: 95, Issue:1 Topics: Administration, Oral; Adolescent; Anti-Bacterial Agents; Cephalexin; Child; Child, Preschool; Dicloxacillin; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Infant; Injections, Intravenous; Methicillin; Nafcillin; Osteomyelitis; Penicillin V; Probenecid; Protein Binding	1979
Gonorrhoea of the throat at a venereological clinic. Incidence and Results of Treatment. The British journal of venereal diseases, 1975, Volume: 51, Issue:6 Topics: Administration, Oral; Ampicillin; Cephalexin; Female; Humans; Male; Palatine Tonsil; Paraphilic Disorders; Pharyngeal Diseases; Probenecid; Sexual Behavior; Sweden	1975
Cephalexin-related nephropathy. JAMA, 1975, Nov-10, Volume: 234, Issue:6 Topics: Administration, Oral; Adult; Cephalexin; Drug Hypersensitivity; Endocarditis; Eosinophilia; Hematuria; Humans; Kidney Diseases; Male; Probenecid	1975
Treatment of gonorrhoea contracted in the Western Pacific Region. The British journal of venereal diseases, 1974, Volume: 50, Issue:2 Topics: Administration, Oral; Cephalexin; Cephaloridine; Gonorrhea; Hong Kong; Humans; Injections, Intramuscular; Male; Naval Medicine; Neisseria gonorrhoeae; Penicillin G Procaine; Philippines; Probenecid; Spectinomycin; Urethritis	1974
Pharmacokinetics of parenteral sodium cephalexin in comparison with cephalothin and cefazolin. Infection, 1974, Volume: 2, Issue:3 Topics: Adult; Cephalexin; Cephalosporins; Cephalothin; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Kinetics; Male; Probenecid; Sulfides; Tetrazoles; Thiadiazoles	1974
Clinical pharmacology of cephalexin administered by intravenous injection. Journal of clinical pathology, 1972, Volume: 25, Issue:6 Topics: Adult; Cephalexin; Cephalosporins; Female; Half-Life; Humans; Injections, Intravenous; Kidney Failure, Chronic; Male; Probenecid; Renal Dialysis; Time Factors	1972
Cephalexin in the treatment of gonorrhea. International journal of clinical pharmacology, therapy and toxicology, 1972, Volume: 6, Issue:1 Topics: Cephalexin; Cephalosporins; Drug Resistance, Microbial; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Probenecid	1972
Cephalexin levels in human bile in presence of biliary tract disease. British medical journal, 1972, Aug-19, Volume: 3, Issue:5824 Topics: Bile; Bile Ducts; Biliary Tract Diseases; Carrier State; Cephalexin; Cholestasis; Gallbladder; Humans; Probenecid; Time Factors; Typhoid Fever	1972
The human intraocular penetration of a new orally effective cephalosporin antibiotic, cephalexin. Annals of ophthalmology, 1971, Volume: 3, Issue:3 Topics: Administration, Oral; Aqueous Humor; Bacterial Infections; Cephalexin; Dose-Response Relationship, Drug; Eye Diseases; Humans; Methods; Probenecid; Structure-Activity Relationship; Time Factors	1971
The pharmacokinetics of cefadroxil associated with probenecid. International journal of clinical pharmacology, therapy, and toxicology, 1981, Volume: 19, Issue:11 Topics: Adult; Bacillus subtilis; Biological Assay; Cefadroxil; Cephalexin; Drug Interactions; Humans; Kinetics; Probenecid	1981
Transfer of probenecid and cephalexin into breast milk. The Annals of pharmacotherapy, 2006, Volume: 40, Issue:5 Topics: Adult; Anti-Bacterial Agents; Breast Feeding; Cephalexin; Diarrhea; Drug Therapy, Combination; Female; Humans; Infant; Lactation; Male; Milk, Human; Probenecid	2006
Management of cellulitis in a pediatric emergency department. Pediatric emergency care, 2007, Volume: 23, Issue:11 Topics: Academic Medical Centers; Adjuvants, Pharmaceutic; Administration, Oral; Adolescent; Anti-Bacterial Agents; British Columbia; Case-Control Studies; Cefazolin; Cellulitis; Cephalexin; Child; Child, Preschool; Cloxacillin; Emergency Service, Hospital; Female; Humans; Infant; Infusions, Intravenous; Male; Patient Admission; Probenecid; Retrospective Studies; Staphylococcus aureus; Streptococcus pyogenes	2007
Intravenous cefazolin plus oral probenecid versus oral cephalexin for the treatment of skin and soft tissue infections: a double-blind, non-inferiority, randomised controlled trial. Emergency medicine journal : EMJ, 2018, Volume: 35, Issue:8 Topics: Adjuvants, Pharmaceutic; Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Canada; Cefazolin; Cephalexin; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Probenecid; Prospective Studies; Soft Tissue Infections	2018
Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma. Therapeutic drug monitoring, 2018, Volume: 40, Issue:6 Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Aged; Aged, 80 and over; beta-Lactams; Cefazolin; Cephalexin; Child; Chromatography, High Pressure Liquid; Drug Monitoring; Floxacillin; Humans; Limit of Detection; Middle Aged; Plasma; Probenecid; Tandem Mass Spectrometry; Young Adult	2018
Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. The Journal of infection, 2021, Volume: 83, Issue:2 Topics: Area Under Curve; Cephalexin; Healthy Volunteers; Humans; Microbial Sensitivity Tests; Probenecid	2021