Page last updated: 2024-08-16

probenecid and bumetanide

probenecid has been researched along with bumetanide in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (27.27)	18.7374
1990's	3 (9.09)	18.2507
2000's	8 (24.24)	29.6817
2010's	13 (39.39)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Foguet, M; Hagenbuch, B; Lübbert, H; Meier, PJ; Stieger, B	1
Grassl, SM; Holtzman, EJ; Race, JE; Williams, WJ	1
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Holland, SD; Williamson, HE	1
Lant, AF	1
Sandström, PE	1
Griffiths, NM; Simmons, NL	1
Bekersky, I; Popick, AC	1
Lau, HS; Shih, LJ; Smith, DE	1
Beermann, B; Lindström, B; Odlind, B	1
Lau, HS; Smith, DE	1
Brater, DC; Chennavasin, P	1
Burckhardt, BC; Burckhardt, G; Wolff, NA	1
Brandt, C; Löscher, W; Römermann, K; Töllner, K	1
Boylan, GB; Cryan, JF; Donovan, MD; Griffin, BT; O'Brien, FE	1
Erker, T; Fedrowitz, M; Hampel, P; Kaczmarek, E; Löscher, W; Römermann, K; Sweet, DH; Töllner, K	1

Reviews

3 review(s) available for probenecid and bumetanide

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for probenecid and bumetanide

Article	Year
Effects of bumetanide on cation and anion transport. Postgraduate medical journal, 1975, Volume: 51 Suppl 6 Topics: Biological Transport, Active; Bumetanide; Clinical Trials as Topic; Diuresis; Diuretics; Humans; Kidney; Natriuresis; Nephrons; Osmolar Concentration; Probenecid; Water-Electrolyte Balance	1975

Other Studies

29 other study(ies) available for probenecid and bumetanide

Article	Year
Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proceedings of the National Academy of Sciences of the United States of America, 1991, Dec-01, Volume: 88, Issue:23 Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Carrier Proteins; Cloning, Molecular; DNA; Female; Gene Library; Liver; Molecular Sequence Data; Molecular Weight; Oocytes; Organic Anion Transporters, Sodium-Dependent; Protein Conformation; Rats; Restriction Mapping; RNA, Messenger; Sodium; Symporters; Taurocholic Acid; Xenopus laevis	1991
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochemical and biophysical research communications, 1999, Feb-16, Volume: 255, Issue:2 Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Blotting, Northern; Carrier Proteins; Chromosomes, Human, Pair 11; Cloning, Molecular; Humans; Kidney; Mice; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Sequence Homology, Amino Acid; Xenopus laevis	1999
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Probenecid inhibition of bumetanide-induced natriuresis in the dog. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 161, Issue:3 Topics: Animals; Bumetanide; Diuresis; Diuretics; Dogs; Female; Infusions, Intra-Arterial; Kidney; Male; Natriuresis; Probenecid; Renal Artery	1979
Evidence for diabetogenic action of bumetanide in mice. European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2 Topics: Animals; Blood Glucose; Body Weight; Bumetanide; Diabetes Mellitus, Experimental; Diuresis; Diuretics; Glucose Tolerance Test; Insulin; Insulin Secretion; Mice; Probenecid	1988
Attribution of [3H]bumetanide binding to the Na+K+Cl 'co-transporter' in rabbit renal cortical plasma membranes: a caveat. Quarterly journal of experimental physiology (Cambridge, England), 1987, Volume: 72, Issue:3 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Binding Sites; Binding, Competitive; Bumetanide; Cell Membrane; Cells, Cultured; Diuretics; Female; Kidney Cortex; Kidney Medulla; Kinetics; Male; Probenecid; Rabbits; Radioligand Assay	1987
Disposition of bumetanide in the isolated perfused rat kidney: effects of probenecid and dose response. The American journal of cardiology, 1986, Jan-24, Volume: 57, Issue:2 Topics: Animals; Biological Transport; Bumetanide; Diuresis; Diuretics; Dose-Response Relationship, Drug; Furosemide; Kidney; Kinetics; Male; Perfusion; Probenecid; Rats	1986
Effect of probenecid on the dose-response relationship of bumetanide at steady state. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:1 Topics: Animals; Bumetanide; Diuresis; Diuretics; Dogs; Dose-Response Relationship, Drug; Kidney; Male; Natriuresis; Probenecid	1983
Coupling between renal tubular secretion and effect of bumetanide. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:6 Topics: Adult; Bumetanide; Chlorides; Diuresis; Diuretics; Drug Interactions; Humans; Infusions, Parenteral; Kidney Tubules; Male; Metabolic Clearance Rate; Probenecid	1983
Determinants of bumetanide response in the dog: effect of probenecid. Journal of pharmacokinetics and biopharmaceutics, 1983, Volume: 11, Issue:1 Topics: Animals; Bumetanide; Diuresis; Diuretics; Dogs; Drug Interactions; Kidney; Kinetics; Male; Natriuresis; Probenecid	1983
Effect of probenecid on response to bumetanide in man. Journal of clinical pharmacology, 1981, Volume: 21, Issue:7 Topics: Adult; Bumetanide; Diuretics; Drug Interactions; Humans; Kidney; Male; Natriuresis; Potassium; Probenecid	1981
Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT). Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:1 Topics: Animals; Anion Transport Proteins; Biological Transport, Active; Bumetanide; Carrier Proteins; Cells, Cultured; Clone Cells; Dicarboxylic Acid Transporters; Diuretics; Dose-Response Relationship, Drug; Escherichia coli Proteins; Flounder; Furosemide; Kidney Tubules, Proximal; Membrane Potentials; Membrane Transport Proteins; Oocytes; p-Aminohippuric Acid; Patch-Clamp Techniques; Probenecid; Substrate Specificity; Xenopus laevis	2000
The organic anion transport inhibitor probenecid increases brain concentrations of the NKCC1 inhibitor bumetanide. European journal of pharmacology, 2015, Jan-05, Volume: 746 Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Brain; Bumetanide; Cell Line; Diuretics; Dogs; Drug Interactions; Female; Half-Life; Humans; Kidney; Membrane Transport Modulators; Mice; Nerve Tissue Proteins; Neurons; Organic Anion Transporters; Probenecid; Recombinant Proteins; Sodium Potassium Chloride Symporter Inhibitors	2015
The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat. The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:4 Topics: Adjuvants, Pharmaceutic; Animals; Biological Transport; Blood-Brain Barrier; Bumetanide; Drug Interactions; Extracellular Fluid; GABA Agents; Hippocampus; Male; Microdialysis; Organic Anion Transporters; Probenecid; Rats, Sprague-Dawley	2015
Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain. Neuropharmacology, 2017, 05-01, Volume: 117 Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Bumetanide; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Diffusion; Female; Membrane Transport Modulators; Mice; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Probenecid	2017