Page last updated: 2024-08-16

probenecid and acetaminophen

probenecid has been researched along with acetaminophen in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (24.32)	18.7374
1990's	9 (24.32)	18.2507
2000's	10 (27.03)	29.6817
2010's	9 (24.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Duggin, GG; Mudge, GH	1
Bito, LZ; Wallenstein, MC	2
Arnold, L; Collins, C; Starmer, GA	1
Dehner, EJ; Martin, ET; Schwartz, JB	1
Kamali, F; Rawlins, MD	1
Cretton, EM; Sommadossi, JP	1
Ignarro, LJ; Wood, KS	1
Bell, GD; Fry, JR; Kamali, F	1
Abernethy, DR; Ameer, B; Greenblatt, DJ; Shader, RI	1
Kim, CS; Mann, JD; O'Tuama, LA; Roe, CR	1
Kamali, F	1
Greenblatt, DJ; Harmatz, JS; Manis, M; Poorman, R; von Moltke, LL	1
Cohen, SD; Emeigh Hart, SG; Khairallah, EA; Wyand, DS	1
Brouwer, KL; Turner, KC	1
Awazu, S; Hayashi, M; Iida, S; Mizuma, T; Sakuma-Sawada, N	2
Elías, MM; Monasterolo, LA; Trumper, L	1
Abe, F; Fujimoto, Y; Fukuda, M; Hasegawa, T; Kitaichi, K; Morishima, T; Takagi, K	1

Reviews

3 review(s) available for probenecid and acetaminophen

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for probenecid and acetaminophen

Article	Year
The effect of probenecid on paracetamol metabolism and pharmacokinetics. European journal of clinical pharmacology, 1993, Volume: 45, Issue:6 Topics: Acetaminophen; Adult; Animals; Arabidopsis Proteins; Drug Interactions; Female; Glucosyltransferases; Half-Life; Humans; In Vitro Techniques; Male; Microsomes, Liver; Probenecid; Rats	1993

Other Studies

33 other study(ies) available for probenecid and acetaminophen

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Renal tubular transport of paracetamol and its conjugates in the dog. British journal of pharmacology, 1975, Volume: 54, Issue:3 Topics: Acetaminophen; Animals; Biological Transport; Dogs; Female; Glomerular Filtration Rate; Glucuronates; Hydrogen-Ion Concentration; Kidney Tubules; Probenecid; Protein Binding; Sulfates	1975
Prostaglandin E1-induced alterations in visually-evoked response and production of epileptiform activity. Neuropharmacology, 1977, Volume: 16, Issue:10 Topics: Acetaminophen; Animals; Bromcresol Green; Electroencephalography; Evoked Potentials; Female; Indomethacin; Photic Stimulation; Probenecid; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Rabbits; Seizures	1977
Hyperthermic effects of supracortically applied prostaglandins after systemic pretreatment with inhibitors of prostaglandin transport and synthesis. The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:2 Topics: Acetaminophen; Animals; Body Temperature; Bromcresol Green; Cerebral Cortex; Drug Interactions; Female; Indomethacin; Male; Perfusion; Probenecid; Prostaglandins; Rabbits	1978
Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol. Pathology, 1976, Volume: 8, Issue:3 Topics: Acetaminophen; Acute Kidney Injury; Animals; Aspirin; Dinitrophenols; Female; Kidney Tubular Necrosis, Acute; Oxyphenbutazone; Phenacetin; Probenecid; Rats	1976
Intragranular starch: comparison of starch USP and modified cornstarch. Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:2 Topics: Acetaminophen; Ascorbic Acid; Biopharmaceutics; Cellulose; Chlorothiazide; Dihydroxyphenylalanine; Excipients; Hardness Tests; Kinetics; Methyldopa; Pressure; Probenecid; Solubility; Starch; Tablets	1975
Influence of probenecid and paracetamol (acetaminophen) on zidovudine glucuronidation in human liver in vitro. Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:6 Topics: Acetaminophen; Adult; Aged; Glucuronates; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Middle Aged; Probenecid; Zidovudine	1992
Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Acetaminophen; Animals; Body Fluid Compartments; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Drug Interactions; Humans; Liver; Probenecid; Rats; Rats, Inbred Strains; Zidovudine	1991
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase. The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine	1987
Salivary secretion of paracetamol in man. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:2 Topics: Acetaminophen; Administration, Oral; Adult; Female; Half-Life; Humans; Male; Mouth Mucosa; Probenecid; Saliva; Time Factors; Trichloroacetic Acid	1987
Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:2 Topics: Acetaminophen; Adult; Drug Interactions; Female; Glucuronates; Humans; Lorazepam; Male; Metabolic Clearance Rate; Middle Aged; Probenecid	1985
Saturable accumulation of the anionic herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), by rabbit choroid plexus: early developmental origin and interaction with salicylates. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:3 Topics: 2,4-Dichlorophenoxyacetic Acid; Acetaminophen; Aging; Animals; Animals, Newborn; Biological Transport; Choroid Plexus; Female; Kinetics; Male; Ouabain; Probenecid; Rabbits; Sodium Salicylate; Structure-Activity Relationship	1983
Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid. Biopharmaceutics & drug disposition, 1993, Volume: 14, Issue:2 Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; In Vitro Techniques; Lorazepam; Macaca; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Probenecid; Rats; Rats, Sprague-Dawley	1993
Acetaminophen nephrotoxicity in the CD-1 mouse. II. Protection by probenecid and AT-125 without diminution of renal covalent binding. Toxicology and applied pharmacology, 1996, Volume: 136, Issue:1 Topics: Acetaminophen; Aminooxyacetic Acid; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Blood Urea Nitrogen; Cytosol; Enzyme Inhibitors; Glutathione; Immunohistochemistry; Injections, Intraperitoneal; Ion Transport; Isoxazoles; Kidney Tubules, Proximal; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Probenecid; Renal Agents	1996
In vitro mechanisms of probenecid-associated alterations in acetaminophen glucuronide hepatic disposition. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:9 Topics: Acetaminophen; Animals; Cytosol; Drug Antagonism; Glutathione Transferase; In Vitro Techniques; Liver; Male; Probenecid; Rats; Rats, Sprague-Dawley	1997
Hepatic uptake of p-nitrophenyl sulfate by transporter that acetaminophen sulfate shares for uptake: sulfate moiety as a vector for metabolite transport. Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Biological Transport, Active; Cells, Cultured; Dose-Response Relationship, Drug; Liver; Male; Nitrobenzenes; Probenecid; Rats; Rats, Wistar; Sulfates; Sulfobromophthalein	1997
Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds. The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:8 Topics: Acetaminophen; Animals; Anions; Cholic Acid; Cholic Acids; Coloring Agents; Drug Interactions; Liver; Male; Nitrobenzenes; Perfusion; Probenecid; Rats; Rats, Wistar; Sulfates; Sulfobromophthalein; Uricosuric Agents	1997
Probenecid protects against In vivo acetaminophen-induced nephrotoxicity in male Wistar rats. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: Acetaminophen; Acute Disease; Animals; Biological Transport; Creatinine; Diuresis; Glomerular Filtration Rate; Glutathione; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Probenecid; Proteinuria; Rats; Rats, Wistar	1998
Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice. Journal of pharmacological sciences, 2005, Volume: 97, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Brain; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Male; Mefenamic Acid; Mice; Organic Anion Transporters, Sodium-Independent; Probenecid; Protein Binding; Shiga Toxin 2	2005