proanthocyanidin-a1 has been researched along with 4-nitrobenzylthioinosine* in 1 studies
1 other study(ies) available for proanthocyanidin-a1 and 4-nitrobenzylthioinosine
| Article | Year |
|---|---|
Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum.
The objective of this study was to evaluate the immunomodulatory effects of proanthocyanidin A-1 (PAA-1) from leaves of Rhododendron spiciferum (Ericaceae). In vitro tests showed that PAA-1 stimulated cell proliferation of splenocytes and peritoneal macrophages significantly enhanced the cytotoxicity of natural killer (NK) cells and increased CD4(+) and CD8(+) cell populations. PAA-1 also regulated the expression of Th1- and Th2-related cytokines. Moreover, this study showed that PAA-1 exhibited a significant effect on NBT dye reduction and lysosomal enzyme activity responses in macrophages, indicating effective phagocytic activation. These results revealed that PAA-1 exhibits immunomodulatory activity without a clear dose response. Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Immunologic Factors; Killer Cells, Natural; Lysosomes; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Phagocytes; Plant Leaves; Proanthocyanidins; Rhododendron; Spleen; Thioinosine | 2010 |