proadifen has been researched along with phenobarbital in 373 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 333 (89.28) | 18.7374 |
| 1990's | 29 (7.77) | 18.2507 |
| 2000's | 10 (2.68) | 29.6817 |
| 2010's | 1 (0.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M | 1 |
| Breyer, U; Junginger, W; Villumsen, D | 1 |
| Jonsson, J | 1 |
| Demetriou, SK; Domino, EF; Wang Lu, LJ | 1 |
| Castro, JA; Diaz Gomez, MI; Godoy, HM | 1 |
| Artigou, JY; Benhamou, JP; Descatoire, V; Pessayre, D; Wandscheer, JC | 1 |
| Freeman, RW; Harbison, RD; Oates, JA; Woosley, RL | 1 |
| Bolt, HM; Filser, JG; Hinderer, RK | 1 |
| Nesković, N; Terzić, M; Vitorović, S | 1 |
| Dacre, JC; Lee, CC; Short, RD | 1 |
| Castro, JA; Diaz Gomez, MI | 1 |
| Ford, JH; Gopinath, C | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Beckett, AH; Dajani, RM; Gorrod, JW | 1 |
| Roach, MK | 1 |
| Grudin, R; Moldèus, P; Orrenius, S; Vadi, H | 1 |
| Belpaire, FM; Bogaert, MG | 2 |
| Belitskiĭ, GA; Bukhman, VM; Konopleva, IA | 1 |
| Gram, TE; Litterst, CL; Mimnaugh, EG | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Carlson, GP; White, JF | 1 |
| Hart, FE; Hew, JT; Willson, RA | 1 |
| Covault, HP; Hostetler, RM; Lehman, T; Peterson, GR | 1 |
| Franklin, MR; Roberts, SM | 1 |
| Shaw, K; Shuster, L; Thompson, ML | 1 |
| Bridges, JW; Chakraborty, J; Shirkey, RS | 1 |
| Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K | 1 |
| Ellis, S; Gill, DP; Kempen, RR; Nash, JB | 1 |
| Zanoli, P | 1 |
| Campbell, RL; Hettrick, JM; Nigro, ND; Suppnick, JD | 1 |
| Buchbauer, G | 1 |
| Ahlborg, UG; Larsson, K; Thunberg, T | 1 |
| Ahlborg, UG; Thunberg, T | 1 |
| Feldman, S; Ravis, WR | 1 |
| Bousquet, WF; Means, JR; Miya, TS; Schnell, RC | 1 |
| Dalvi, RR; Peeples, A | 1 |
| Crawford, RD; Davis, HL; Johnson, DD | 1 |
| Chivrac, D; Dumont, M; Erlinger, S | 1 |
| Andersen, ME; Jenkins, LJ; Jones, RA | 1 |
| Endo, M; Ishi, A; Mineura, K; Oishi, T | 1 |
| Hanzlik, RP; Traiger, GJ; Vyas, KP | 2 |
| Dalvi, RR; Howell, CD | 1 |
| Agosin, M; Capdevila, J; Naquira, C; Paulin, J | 1 |
| Banerjee, S; Conney, AH; Kuntzman, R; Levin, W; Somogyi, A | 1 |
| Parke, DV | 1 |
| Capdevila, J; Helia, O; Jakobsson, SW; Jernström, B; Orrenius, S | 1 |
| Abrahamson, LJ; Allen, JR; Cartens, LA; Marlar, RJ | 1 |
| Bauer, J; Gerber, N; Gordon, P; Leger, RM; Lynn, RK; Smith, RG | 1 |
| Burgschat, H; Netter, KJ | 1 |
| Kearney, PC; Menzer, RE; Nelson, JO; Pimmer, JR | 1 |
| Harbison, RD; Lubin, DJ; Mantilla-Plata, B | 1 |
| Dedinas, J; DiVincenzo, GD; Hamilton, ML; Kaplan, CJ | 1 |
| David, JC | 1 |
| Drew, R; Priestly, BG | 1 |
| Franklin, MR | 1 |
| Agosin, M | 2 |
| Kuga, T; Moroi, K; Satoh, T; Ushiyama, S | 1 |
| McDevitt, DG; Nies, AS; Rush, BD; Strother, JR; Wilkinson, GR | 1 |
| Turnbull, MJ; Watkins, JW | 1 |
| Anderson, J; Nievel, JG; Skrbic, TR | 1 |
| Chen, CF; Chow, SY; Tsou, CT | 1 |
| McDonagh, AF; Schmid, R | 1 |
| Frantz, CN; Malling, HV | 1 |
| Aeschbacher, HU; Atkinson, J; Domahidy, B | 1 |
| Franklin, MR; James, RC | 1 |
| Jablońska, JK; Piotrowski, JK; Wiśniewska-Knypl, JM | 1 |
| Borison, HL; Longnecker, DS; Smith, RP; Snow, SR | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Aeschbacher, HU | 1 |
| Jabłońska, JK; Wiśniewska-Knypl, JM | 1 |
| Gibson, JE; Preache, MM | 1 |
| Drew, RT; Fouts, JR; Lo, RJ; Roth, RP | 1 |
| Gangolli, SD; Heading, CE; Lake, BG; Lloyd, AG; Phillips, JC | 1 |
| Gut, I; Holecek, V; Kopecký, J; Nerudová, J | 1 |
| Barzaghi, D; Salvaterra, M; Setnikar, I; Veronese, M | 1 |
| Herczeg, T; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD | 1 |
| Lohmann, SM; Miech, RP | 1 |
| Bulger, WH; Roche, EB; Wells, PR | 1 |
| Marietta, MP; Pudwill, CR; Trevor, AJ; Way, WL; White, PF | 1 |
| Banerjee, S; Van Duuren, BL | 1 |
| Alberts, DS; van Daalen Wetters, T | 1 |
| Fitzgerald, TJ | 1 |
| Giri, SN; Gribble, DH; Peoples, SA | 1 |
| Fujie, K; Ito, Y; Maeda, S | 1 |
| Couture, J; Dahlström-King, L; Plaa, GL | 1 |
| Cochón, AC; San Martín de Viale, LC; Wainstok de Calmanovici, R | 1 |
| Kaneko, H; Oguri, K; Takeuchi, K; Yamada, H; Yoshimura, H | 1 |
| Hirobe, M; Ohi, H; Ohta, S; Takahara, E | 1 |
| Brewster, WK; Johnson, MP; Nichols, DE; Steele, TD; Yim, GK | 1 |
| Pai, KS; Ravindranath, V | 1 |
| Giri, SN; Siegel, DM | 1 |
| Cavazos, R; Diaz, RG; Farooqui, MY | 1 |
| James, RC; Pounds, JG; Roberts, SM | 1 |
| Ross, SB | 2 |
| Ichikawa, H; Yoneyama, M | 1 |
| Ali, SF; Gollamudi, R; Kolta, M; Leakey, JE; Lipe, G; Lopez, M; Newport, G; Slikker, W; Webb, P | 1 |
| Castonguay, A; Charest, M; Rossignol, G | 1 |
| Berndt, WO; Christenson, WR; Davis, ME | 1 |
| Marselos, M; Vasiliou, V | 1 |
| Conolly, RB; Osimitz, TG | 1 |
| Bender, PE; Eckardt, RD; Leonard, TB; Newton, JF; Romano, MC; Straub, KM | 1 |
| Haim, N; Nemec, J; Roman, J; Sinha, BK | 1 |
| Furukawa, N; Sato, M; Suzuki, Y | 1 |
| Kuroiwa, Y; Yamada, Y; Yamamoto, T; Yoshida, T | 1 |
| Bruner, LH; Carpenter, LJ; Hamlow, P; Roth, RA | 1 |
| Petry, TW; Sipes, IG | 1 |
| Kammerer, RC; Lampe, MA | 1 |
| Kuroiwa, Y; Oguro, T; Yoshida, T | 1 |
| Chikuni, O; Nhachi, CF | 1 |
| Iwasaki, M; Kamataki, T; Kitada, M; Komori, M; Miura, T; Ohi, H; Ono, K | 1 |
| Mulder, GJ; Nagelkerke, JF; Paul, LC; Schwarz, EP; Tijdens, RB; Winters, MF | 1 |
| Brooks, B; Brown, P; Byers, LW; Capdevila, J; Dowell, R; Muirhead, E; Pitcock, JA | 1 |
| Imamichi, T; Ogata, A; Sasaki, M; Suzuki, K; Yoneyama, M | 1 |
| Duddy, SK; Hsia, MT | 1 |
| Blakey, DC; White, IN | 1 |
| Bogush, TA; Sitdikova, SM; Syrkin, AB | 1 |
| Chiang, HJ; Kuroiwa, Y; Suzuki, T; Yanaura, S; Yoshida, T | 1 |
| Smith, AG; Stewart, FP | 1 |
| Gram, TE; Okine, LK | 1 |
| Flory, W; Henk, WG; Turk, MA | 1 |
| Coleman, R; Kan, KS | 1 |
| Amezcua, JL; Girón, E; Martinez-Tabche, L; Mourelle, M | 1 |
| Nakamura, K; Nishigaki, T; Tanaka, M | 1 |
| Burke, MD; Elcombe, CR; Haaparanta, T; Halpert, J; Mayer, RT; Thompson, S | 1 |
| Kuwahara, S; Mannering, GJ | 1 |
| Inoue, T; Kishi, T; Niwaguchi, T; Suzuki, S; Yasuda, T | 1 |
| Blouin, RA; Brouwer, KL; Chang, SL; Hamann, SR; Kaltenborn, KE; McAllister, RG; Tan, TG; Vore, M | 1 |
| Kim, HL | 1 |
| Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A | 2 |
| Ivanova, VA; Kasatkin, VI; Nechiporenko, SP; Tiunov, LA | 1 |
| Strecker, M; Wolff, T | 1 |
| Bogush, TA; Syrkin, AB | 1 |
| Combes, RD; Walters, JM | 1 |
| Goochee, JM; Gram, TE; Okine, LK | 1 |
| de Ruiter, C; de Vries, J; Gobas, F; Kootstra, PR; Pinedo, HM; van Maanen, JM | 1 |
| Eulenstedt, C; Koransky, W; Leberl, C; Schlicht, I; Schulte-Hermann, R; Zimek, M | 1 |
| Van Dyke, RA; Wood, CL | 1 |
| Bickel, MH; Willi, P | 1 |
| Bolt, HM; Kappus, H; Remmer, H | 2 |
| Pleuvry, B; Srinivasan, B; Wahdi, C | 1 |
| Kampffmeyer, HG | 2 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| Gupta, RP; Raj, HG; Santhanam, K; Venkitasubramanian, TA | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Kato, R | 1 |
| Cucinell, SA; Dayton, PG; Perel, JM; Weiss, M | 1 |
| Conney, AH; Kuntzman, R; Welch, R | 1 |
| Ernzerhoff, C; Holtz, P; Palm, D | 2 |
| Burgison, RM; Dietz, AJ | 1 |
| Bickel, MH; Gigon, PL | 2 |
| Castro, JA; Gomez, MI | 1 |
| Kato, R; Omori, Y; Takanaka, A | 1 |
| Chopra, P; Nayak, NC; Ramalingaswami, V | 1 |
| Japundzić, I; Japundzić, M; Mimic-Oka, J | 1 |
| Carlson, GP; Fuller, GC | 1 |
| Illing, HP; Netter, KJ | 1 |
| Leibman, KC | 1 |
| Kerza-Kwiatecki, A; Mazel, P; Simanis, J | 1 |
| Kupfer, D | 1 |
| Jones, TM; Kupfer, D; Partridge, R | 1 |
| Ichihara, K; Kusunose, E; Kusunose, M | 1 |
| Brodeur, J; Gascon, AL | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 2 |
| Blackham, A; Spencer, PS | 1 |
| Carlson, GP; DuBois, KP | 1 |
| Kutt, H; Verebely, K | 1 |
| Kataoka, S; Takabatake, E | 1 |
| Topham, JC | 1 |
| Kalant, H; Khanna, JM | 1 |
| Garner, JV; Garner, RC; Hanson, RS; Miller, EC; Miller, JA | 1 |
| Mattocks, AR; White, IN | 1 |
| Mazel, P; Shargel, L | 1 |
| Chopra, P; Nayak, NC; Ramalingaswami, V; Roy, S | 1 |
| Kupfer, D; Levin, E | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, SB | 1 |
| Allen, LM; Creaven, PJ | 1 |
| Cousins, MJ; Hitt, BA; Kosek, JC; Love, FV; Mazze, RI | 1 |
| Tanayama, S | 1 |
| Gillette, JR | 1 |
| Borg, KO; Grundin, R; Moldéus, P; Orrenius, S; Skånberg, I; von Bahr, C | 1 |
| Fang, VS; Tashjian, AH | 1 |
| Ikeda, M; Imamura, T; Otsuji, H | 1 |
| Allen, JG; Seawright, AA | 1 |
| Hildebrandt, AG | 1 |
| Belpaire, FM; Lee, NH | 1 |
| Collins, AC; Deitrich, RA; Erwin, VG | 1 |
| Fisher, JW; Paulo, LG; Roh, BL | 1 |
| Bus, JS; Gibson, JE; Short, RD | 1 |
| Krishna, G; Reid, WD | 1 |
| Becker, BA; Murthy, VV; Steele, WJ | 1 |
| Fiserova-Bergerova, V | 1 |
| Berman, ML; Bochantin, J; Hagler, K; Lowe, HJ | 1 |
| Gilles, FH; Kaplan, ML; Murphy, SD | 1 |
| Murphy, SD; Singleton, SD | 1 |
| Kupferberg, HJ; Rapport, RL | 1 |
| Evans, GH; Shand, DG; Wilkinson, GR | 1 |
| Dybing, E | 1 |
| Moroi, K; Sato, T | 1 |
| Agosin, M; Capdevila, J; Morello, A; Perry, AS | 1 |
| Castro, JA; D'Acosta, N; de Castro, CR; de Ferreyra, EC; Díaz Gómez, MI | 1 |
| Miranda, CL; Webb, RE | 1 |
| Gillette, JR; Hamrick, M; Jollow, DJ; Mitchell, JR; Stripp, B; Zampaglione, N | 1 |
| Back, KC; Murphy, JP; Van Stee, EW | 1 |
| Brodie, BB; Gillette, R; Krishna, G; Reid, WD | 1 |
| Sotaniemi, EA | 1 |
| Archakov, AI; Blinder, LV; Gasparian, SA; Kliuchnikova, ZhI; Maliugin, EF | 1 |
| Badawy, AA; Evans, M | 1 |
| Frommer, U; Ullrich, V; Weber, P | 1 |
| Filippich, LJ; Seawright, AA; Steele, DP | 1 |
| Bush, MT; Gerber, N; Holcomb, RR | 1 |
| Gigon, PL; Krishna, G; Sipes, IG | 1 |
| Gustafsson, JA; Ingelman-Sundberg, M | 1 |
| Barratt, ES; Cohn, RA; Pirch, JH | 1 |
| Cohen, ML; Trevor, AJ | 1 |
| Gillette, JR; Jollow, DJ; Mitchell, JR; Zampaglione, N | 1 |
| Bellward, GD; Black, NB; Dayton, PG; O'Brien, L; Perel, JM | 1 |
| Burdino, E; Gabriel, L; Torrielli, MV; Ugazio, G | 1 |
| Harbison, RD; Mantilla-Plata, B | 1 |
| Allen, JR; Chesney, CF; Hsu, IC | 1 |
| Nichol, AW | 1 |
| Bogaert, MG; De Schaepdryver, AF; Rosseel, MT | 2 |
| Becker, BA; Gibson, JE | 2 |
| Field, RB; Gang, M; Kline, I; Venditti, JM; Waravdekar, VS | 1 |
| Prabhu, VG | 2 |
| Oester, YT; Prabhu, VG; Rise, NL | 1 |
| Eade, NR; Renton, KW | 1 |
| Castle, MC; Lage, GL | 1 |
| Horie, T; Kitada, M; Kitagawa, H | 1 |
| Hrdlicka, J; Seawright, AA | 1 |
| Gibson, JE; Hayes, FD; Short, RD | 1 |
| Mattocks, AR | 1 |
| Malathi, K; Padmanaban, G; Rao, MR | 1 |
| Levine, WG | 1 |
| De Matteis, F | 1 |
| Brown, DR; Murphy, SD | 2 |
| Brodie, BB; Christie, B; Krishna, G; Mitchell, JR; Moskowitz, J; Reid, WD | 1 |
| Becker, BA; Harbison, RD | 2 |
| Kato, R; Oshima, T; Takayanagi, M | 1 |
| Fujimoto, M; Kitahara, A; Miyao, K; Ogo, T | 1 |
| Aebi, H; Baggiolini, M; Dewald, B | 1 |
| Adamson, RH; Hart, LG | 1 |
| Bond, EJ; De Matteis, F | 1 |
| Glende, EA; Rao, KS; Recknagel, RO | 1 |
| Alvares, AP; Mannering, GJ | 1 |
| Marchand, C; McLean, S; Plaa, GL | 1 |
| Bianchetti, A; Jori, A; Prestini, PE | 1 |
| Levine, WG; Millburn, P; Smith, RL; Williams, RT | 1 |
| Nakazawa, K | 1 |
| Aust, SD; Pederson, TC | 1 |
| Bickel, MH; Minder, R | 1 |
| Calhoun, FJ; Schrogie, JJ; Tolson, WW | 1 |
| Conway, MW; Kaul, PN | 1 |
| Kamataki, T; Kitagawa, H; Tanabe, Y | 1 |
| Ikeda, M; Otsuji, H | 1 |
| Weisburger, EK; Weisburger, JH; Yamamoto, RS | 1 |
| Calderoni, FJ; Mitoma, C; Neubauer, SE; Tagg, JS; Tanabe, M; Yasuda, D | 1 |
| Mueller, RA; Shideman, FE | 1 |
| Huidobro, F; Huidobro, JP; Larraín, G | 1 |
| Mannering, GJ; Sladek, NE | 1 |
| Tephly, TR; Tinelli, F; Watkins, WD | 1 |
| Anders, MW; Furner, RL; McCarthy, JS; Stitzel, RE | 1 |
| Plaa, GL; Roberts, RJ | 1 |
| Glasson, B | 1 |
| Burger, PC; Herdson, PB | 1 |
| Ansel, HC; Wade, AE | 1 |
| Anders, MW; Mannering, GJ | 1 |
| Rentsch, G; Wittekind, D | 1 |
| Blake, DA; Cascorbi, HF; Krantz, JC; Rozman, RS | 1 |
| Bassan, P; Meldolesi, J; Morini, MT; Vincenzi, L | 1 |
| Aldous, CN; Chetty, CS; Desaiah, D | 1 |
| Kärki, NT; Rautio, A; Saarni, HU; Sotaniemi, EA | 1 |
| Oguri, K; Watanabe, K; Yamamoto, I; Yoshimura, H | 1 |
| de Valkeneer, FD; Gilbert, PJ; Mercier, M; Poncelet, F; Rollmann, B; Rondelet, J | 1 |
| Gad-El-Karim, MM; Harper, BL; Legator, MS | 1 |
| Nagata, K; Yoshihara, S; Yoshimura, H | 1 |
| Baillie, TA; Prickett, KS | 1 |
| Ater, SB; Madsen, JA; Matsuo, F; Swinyard, EA; Tolman, KG | 1 |
| Cameron, RC; Farber, E; Hayes, MA; Jago, MV; Roberts, E; Safe, SH | 1 |
| Bogush, TA; Sitdikova, SM | 1 |
| Bahnson, LS; Buckpitt, AR; Franklin, RB | 1 |
| Khera, KS | 1 |
| Imamura, T | 1 |
| Cornish, HH; Johnson, DE; Riley, MG | 1 |
| Bachmann, KA; Sullivan, TJ | 1 |
| Chakrabarti, S; Law, FC | 1 |
| Hales, BF; Jain, R | 1 |
| Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT | 1 |
| Axelson, JE; Venkataramanan, R | 1 |
| Davis, M; Powell-Jackson, PR; Smith, HM; Tredger, JM; Williams, R | 1 |
| Boyd, MR; Burka, LT; Sastry, BV; Wilson, BJ | 1 |
| Hines, RN; Nelson, RE; Prough, RA; Sieg, MS; Wiebkin, P | 1 |
| Siemann, DW | 1 |
| DePierre, JW; Meijer, J | 1 |
| Egashira, T; Kuroiwa, Y; Yamamoto, T; Yoshida, T | 1 |
| Breeze, RG; Carlson, JR; Leung, CT | 1 |
| Fukuto, TR; Gandy, J; Hasegawa, L; Imamura, T | 1 |
| Islam, SI; Zaher, FA | 1 |
| Ando, R; Kisara, K; Ogura, Y; Onodera, K; Sakurada, S; Tadano, T; Takahashi, N | 1 |
| Mannering, GJ; Schwen, RJ | 1 |
| Franklin, MR; Pershing, LK | 1 |
| Breger, RK; Franklin, RB; Griffin, KA; Johnson, CB | 1 |
| Bechtold, MM; Bruenner, U; Gee, DL; Tappel, AL | 1 |
| Little, PJ; Ryan, AJ | 1 |
| Islam, SI | 1 |
| Bellward, GD; Gontovnick, LS | 1 |
| Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
| Massey, TE; McElligott, TF; Racz, WJ; Walker, RM | 1 |
| Ishmael, J; Lock, EA | 1 |
| Inoue, T; Murata, T; Niwaguchi, T | 1 |
| Carlson, GP | 2 |
| Latif, SA; McDermott, MJ; Morris, DJ | 1 |
| Bogush, TA; Donenko, FV; Syrkin, AB | 1 |
| Nagasawa, HT; Zera, RT | 1 |
| Iverson, F; Khera, KS | 1 |
| Brodeur, J; Chakrabarti, S | 1 |
| Berg, IE; Chaturvedi, AK; Rao, NG | 1 |
| Dent, JG; Sun, JD | 1 |
| Hollenberg, PF; Koop, DR | 1 |
| Kaul, PN; Kulkarni, SK | 1 |
| DeMaster, EG; Nagasawa, HT; Shirota, FN | 1 |
| Anders, MW; Ratnayake, JH; Stevens, JL | 1 |
| Brooker, JD; Elliott, WH; Lim, LK; May, BK; Srivastava, G | 1 |
| Chang, TK; Chen, G; Waxman, DJ | 1 |
| Ahmed, AE; Burka, LT; Ghanayem, BI; Sanchez, IM | 1 |
| Pai, KS; Ravindranath, V; Sriram, K | 1 |
| Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Bend, JR; Knickle, LC | 1 |
| Bondy, SC; Naderi, S | 1 |
| Bennett, BM; McDonald, BJ | 1 |
| de Montigny, C; Debonnel, G; Monnet, FP | 1 |
| Advenier, C; Dubor, F; Palette, C; Rovei, V | 1 |
| Furukawa, Y; Sugiyama, M; Susa, N; Ueno, S | 1 |
| Burka, LT; Ghanayem, BI | 1 |
| Burrows, GE; Eissa, FZ; Lish, JW; Qualls, CW | 1 |
| Altuntas, TG; Gorrod, JW | 1 |
| Choi, YJ; Kim, WB; Kwon, JW; Lee, HJ; Lee, MG; Yang, J | 1 |
| Melancon, MJ; Renauld, AE; Sordillo, LM | 1 |
| Abdel-Aziz, AH; Abdel-Naim, AB; Abo-Salem, O; Hamada, FM; Mostafa, AM | 1 |
| Bani, M; Brogin, G; Hengstler, JG; Oesch, F; Strolin-Benedetti, M | 1 |
| Bu, S; Kim, S; Kim, Y; Lee, M | 1 |
| Hurh, E; Kim, S; Kim, Y; Lee, A; Lee, E; Lee, M | 1 |
| Abdel-Rahman, MS; El-Tawil, OS | 1 |
| Archakov, AI; Karuzina, II; Lisitsa, AV; Petushkova, NA; Zgoda, VG | 1 |
| Haberle, D; Magyar, K; Szökõ, E | 1 |
| Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E | 1 |
| Abbott, FS; Chang, TK; Chen, J; Tong, V | 1 |
| COON, JM; WELCH, RM | 1 |
| HENDERSON, JF; MAZEL, P | 1 |
| CONNEY, AH; JACOBSON, M; KUNTZMAN, R; SCHNEIDMAN, K | 1 |
| EICH, WF; FUJIMOTO, JM; NICHOLS, HR | 1 |
| Chiba, K; Hosokawa, M; Kobayashi, K; Mimura, N; Nakamura, Y; Shimada, N | 1 |
| Benz, FW; Nerland, DE | 1 |
| Ahmad Bustamam, A; Hasiah, AH; Israf, DA; Khairi, HM; Somchit, N; Sulaiman, MR; Wong, CW; Zuraini, A | 1 |
| Ha, HW; Jeon, TW; Jeong, HG; Jeong, TC; Kang, MJ; Kang, W; Ko, GS; Lee, SK; Lyoo, WS; Yoo, JW | 1 |
6 review(s) available for proadifen and phenobarbital
| Article | Year |
|---|---|
[Studies of papaverine metabolism in animals].
Topics: Animals; Cats; Chromatography, Gas; Chromatography, Thin Layer; Dogs; Enzyme Induction; Female; Guinea Pigs; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Oxidoreductases, O-Demethylating; Papaverine; Phenobarbital; Proadifen; Protein Binding; Rabbits; Rats; Scintillation Counting; Tritium | 1977 |
Induction of the drug-metabolizing enzymes.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Barbiturates; Benzopyrene Hydroxylase; Benzopyrenes; Cytochrome P-450 Enzyme System; Diet; Endoplasmic Reticulum; Enzyme Induction; Female; Glucuronosyltransferase; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pregnancy; Proadifen; Protein Biosynthesis; Rats; Species Specificity; Transcription, Genetic | 1975 |
The enzymatic formation of bilirubin.
Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen | 1975 |
Sex-related differences in drug metabolism.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Estradiol; Female; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Pentobarbital; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Proadifen; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet; Strychnine; Testosterone | 1974 |
Factors influencing steroid hydroxylases in liver microsomes.
Topics: Age Factors; Animals; Carbon Isotopes; Chlordan; DDT; Dogs; Estradiol; Guinea Pigs; Hexobarbital; In Vitro Techniques; Insecticides; Liver; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen Consumption; Phenobarbital; Phenylbutazone; Phosphates; Polycyclic Compounds; Proadifen; Progesterone; Rabbits; Rats; Sex Factors; Steroids; Testosterone | 1966 |
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.
Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Ethylamines; Hydrogen-Ion Concentration; In Vitro Techniques; Isocitrate Dehydrogenase; Methylation; Metyrapone; Microsomes, Liver; Morphinans; Oxidation-Reduction; Phenobarbital; Proadifen; Pseudomonas; Rats; Spectrum Analysis | 1972 |
367 other study(ies) available for proadifen and phenobarbital
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes | 1976 |
Phenobarbital-induced prolongation of half-life and alteration of distribution of a phenothiazine drug metabolite in the rat.
Topics: Animals; Antipsychotic Agents; Cytochrome P-450 Enzyme System; DDT; Half-Life; In Vitro Techniques; Kidney; Male; Microsomes, Liver; Morphine Derivatives; Perazine; Phenobarbital; Proadifen; Rats; Time Factors | 1976 |
On the aromatic hydroxylation of amphetamine in rat liver microsomes and perfused liver preparations: effects of long-term administration.
Topics: Administration, Oral; Amphetamines; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Desipramine; Fenfluramine; Hydroxylation; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Perfusion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Effects of various neuroleptics, phenobarbital and SKF 525-A on dimethyltryptamine content in rat brain and liver.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Half-Life; In Vitro Techniques; Liver; Male; N,N-Dimethyltryptamine; Phenobarbital; Proadifen; Rats; Time Factors; Tryptamines | 1978 |
Mechanism of dimethylnitrosamine metabolism and activation in rats.
Topics: Animals; Biotransformation; Carbon Dioxide; Cobalt; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrosamines; Nucleic Acids; Phenobarbital; Proadifen; Protein Binding; Rats; Subcellular Fractions | 1978 |
Formation and inactivation of a chemically reactive metabolite of vinyl chloride.
Topics: Animals; Cysteine; Cytochrome P-450 Enzyme System; DDT; Epoxide Hydrolases; Epoxy Compounds; Glutathione; Hydrocarbons, Chlorinated; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Protein Binding; Rats; Vinyl Chloride; Vinyl Compounds | 1979 |
Evidence for the biotransformation of procainamide to a reactive metabolite.
Topics: Acetylation; Animals; Biotransformation; Hydralazine; Male; Mice; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Procainamide; Salmonella typhimurium | 1979 |
Rat liver microsomal uptake and irreversible protein binding of [1,2-14C]vinyl bromide.
Topics: Animals; In Vitro Techniques; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Protein Binding; Rats; Species Specificity; Thiadiazoles; Vinyl Compounds | 1978 |
[Acute toxicity of carbaryl and propoxur in mice previously treated with phenobarbitone and SKF 525-A].
Topics: Animals; Carbaryl; Female; Male; Mice; Phenobarbital; Proadifen; Propoxur | 1978 |
A species comparison of 2,4-dinitrotoluene metabolism in vitro.
Topics: Animals; Carbon Radioisotopes; Dinitrobenzenes; Dogs; Female; Haplorhini; Liver; Macaca mulatta; Male; Nitro Compounds; Phenobarbital; Proadifen; Rabbits; Sex Factors; Species Specificity; Toluene | 1979 |
Further studies on the mechanism of the carbon tetrachloride induced polysome breakdown.
Topics: Age Factors; Amitrole; Animals; Carbon Tetrachloride; Cycloheximide; In Vitro Techniques; Liver; Male; Malonates; Methylcholanthrene; Mice; Mice, Inbred A; Niacinamide; Phenobarbital; Polyribosomes; Proadifen; Pyrazoles; Rats | 1976 |
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT; Ditiocarb; Drug Interactions; Enzyme Induction; Female; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Phenylbutazone; Proadifen; Rats; Sleep | 1975 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
In vitro hepatic and extra-hepatic reduction of (minus)-nicotine-1'-N-oxide in rats.
Topics: Anaerobiosis; Animals; Carbon Monoxide; Chromatography, Gas; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Digestive System; Duodenum; Edetic Acid; Flavins; Gastric Mucosa; Ileum; In Vitro Techniques; Intestines; Kidney; Kinetics; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mitochondria, Liver; Myocardium; NADH, NADPH Oxidoreductases; NADP; Nicotine; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Proadifen; Proteins; Rats | 1975 |
Microsomal ethanol oxidation: activity in vitro and in vivo.
Topics: Animals; Azides; Carbon Monoxide; Catalase; Cyanides; Ethanol; Hydrogen Peroxide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Pyrazoles; Rats | 1975 |
Drug metabolism in isolated rat liver cells.
Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium | 1975 |
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Methylcholanthrene; Mice; Microsomes; Oxidoreductases; Phenobarbital; Premedication; Proadifen; Rauscher Virus; Spleen; Tegafur | 1979 |
Comparative alterations in extrahepatic drug metabolism by factors known to affect hepatic activity.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Rabbits; Rats; Starvation | 1977 |
Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats.
Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Disulfiram; Ethanol; Male; Maleates; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats; Vinyl Chloride; Vinyl Compounds | 1977 |
Influence of alterations in drug metabolism on spontaneous and epinephrine-induced cardiac arrhythmias in animals exposed to trichloroethylene.
Topics: Animals; Aroclors; Arrhythmias, Cardiac; Biphenyl Compounds; Diethylamines; Drug Interactions; Electrocardiography; Enzyme Inhibitors; Epinephrine; Male; Phenobarbital; Proadifen; Rabbits; Rats; Trichloroethylene | 1979 |
Breath analysis of 14CO2 production from aminopyrine in the normal rat.
Topics: Aminopyrine; Animals; Breath Tests; Carbon Dioxide; Disulfiram; Fasting; Male; Phenobarbital; Proadifen; Rats; Time Factors; Tissue Distribution | 1979 |
Acute inhibition of oxidative drug metabolism by propoxyphene (Darvon).
Topics: Animals; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Enzyme Induction; Liver; Male; Mice; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Proadifen; Proteins | 1979 |
Modification of hepatic microsomal oxidative drug metabolism in rats by the opiate maintenance drugs acetylmethadol, propoxyphene, and methadone.
Topics: Animals; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1979 |
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine; Male; Mice; Mice, Inbred Strains; Necrosis; Phenobarbital; Proadifen; Sleep | 1979 |
Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1979 |
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors | 1979 |
Modifications of benzene myelotoxicity and metabolism by phenobarbital, SKF-525A and 3-methylcholanthrene.
Topics: Animals; Benzene; Leukocytosis; Leukopenia; Male; Methylcholanthrene; Phenobarbital; Phenols; Proadifen; Rats | 1979 |
Mechanism of protection with 2,4-monofurfurylidene-tetra-O-methyl sorbitol (MSF) against Amanita phalloides toxicity in mice.
Topics: Amanita; Animals; Endoplasmic Reticulum; Female; Furans; Liver; Mice; Mushroom Poisoning; Phalloidine; Phenobarbital; Proadifen; Rats; Sorbitol; Time Factors | 1979 |
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Benzoflavones; Biotransformation; Chlorides; Cobalt; Diet; Disulfiram; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats | 1978 |
[Phytopharmacological study on proadiphene, amiphenazole and bemegride in association with phenobarbitone (author's transl)].
Topics: Bemegride; Drug Interactions; Phenobarbital; Plants; Proadifen; Seeds; Stimulation, Chemical; Thiazoles | 1977 |
Metabolism of pentachlorophenol in vivo and in vitro.
Topics: Animals; Chlorophenols; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Proadifen; Rats; Time Factors | 1978 |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the in vivo and in vitro dechlorination of pentachlorophenol.
Topics: Animals; Chlorophenols; Dioxins; In Vitro Techniques; Male; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Rats; Time Factors | 1978 |
Effect of enzyme-inducing and enzyme-inhibiting agents on drug absorption I: 3-O-methylglucose transport in rats.
Topics: Animals; Benzopyrenes; Biological Transport; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Kinetics; Male; Methylglucosides; Methylglycosides; Phenobarbital; Proadifen; Rats | 1978 |
Correlation of phenobarbital-and SKF 525-A-induced modification of pentobarbital hypnosis with alteration of in vivo and in vitro pentobarbital metabolism in the rat.
Topics: Animals; Drug Interactions; Hypnosis; Liver; Male; Pentobarbital; Phenobarbital; Proadifen; Rats | 1978 |
Toxicologic studies of N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide (captan): its metabolism by rat liver drug-metabolizing enzyme system.
Topics: Aniline Hydroxylase; Animals; Benzphetamine; Biotransformation; Captan; Cytochrome P-450 Enzyme System; Male; Maleates; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1978 |
Epileptiform seizures in domestic fowl. VIII. Anticonvulsant activity of primidone and its metabolites, phenobarbital and phenylethylmalonamide.
Topics: Animals; Anticonvulsants; Chickens; Dimethyl Sulfoxide; Female; Male; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone; Proadifen; Time Factors | 1978 |
Lack of parallelism between microsomal enzyme induction and phenobarbital-induced hypercholeresis in the rat.
Topics: Animals; Bile; Cholagogues and Choleretics; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Time Factors | 1978 |
The acute toxicity of single, oral doses of 1,1-dichloroethylene in the fasted, male rat: effect of induction and inhibition of microsomal enzyme activities on mortality.
Topics: Animals; Bromobenzenes; Carbon Tetrachloride; Dichloroethylenes; Hydrocarbons, Chlorinated; Male; Microsomes, Liver; Phenobarbital; Proadifen; Pyrazoles; Rats | 1978 |
[Metabolism of glybuzole(2-benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole) in rats after pretreatment of phenobarbital, SKF 525A and carbon tetrachloride (author's transl)].
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Male; Phenobarbital; Proadifen; Rabbits; Rats; Sulfonamides; Thiadiazoles | 1978 |
Substituent effects on the hepatotoxicity of thiobenzamide derivatives in the rat.
Topics: Alanine Transaminase; Animals; Benzamides; Bilirubin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Male; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship; Thioamides; Thiones; Triglycerides | 1978 |
Interaction of parathion and malathion with hepatic cytochrome P-450 from rats treated with phenobarbital and carbon disulfide.
Topics: Aniline Compounds; Animals; Carbon Disulfide; Cytochrome P-450 Enzyme System; Drug Interactions; Malathion; Male; Microsomes, Liver; Parathion; Phenobarbital; Proadifen; Rats | 1978 |
Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Cytochrome P-450 Enzyme System; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Phenobarbital; Proadifen; Ribosomes; Trypanosoma cruzi | 1976 |
Inhibition of the acute toxicity and adrenocorticolytic effect of 7,12-dimethylbenz(a)anthracene by isopropylvaleramide and allylisopropylacetamide in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetamides; Adrenal Cortex; Adrenal Glands; Allylisopropylacetamide; Amides; Animals; Barbiturates; Benz(a)Anthracenes; Benzopyrenes; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Methylcholanthrene; Pentobarbital; Phenobarbital; Proadifen; Rats; Secobarbital; Time Factors; Valerates | 1975 |
Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration.
Topics: Animals; Cell Fractionation; Chromatography, Agarose; Cytochrome P-450 Enzyme System; Cytochromes; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Rats; Spectrum Analysis; Stimulation, Chemical; Ultracentrifugation | 1975 |
Responses of rats and nonhuman primates to 2,5,2',5'-tetrachlorobiphenyl.
Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Drug Antagonism; Drug Synergism; Female; Haplorhini; Liver; Macaca mulatta; Male; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats | 1975 |
The metabolism of d-, l- and dl-methadone in the isolated perfused rat liver.
Topics: Animals; Biotransformation; Half-Life; Isomerism; Liver; Methadone; Perfusion; Phenobarbital; Proadifen; Rats | 1977 |
Application of A. C.-polarography in a study of p-nitroanisole metabolism and its kinetic properties.
Topics: Animals; Anisoles; Catechols; Dealkylation; Hydroxylation; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Phenobarbital; Polarography; Proadifen; Proteins; Rats; Time Factors | 1977 |
2,3,7,8-tetrachlorodibenzo-p-dioxin: in vitro binding to rat liver microsomes.
Topics: Animals; Dioxins; Glutathione; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Rats; Time Factors | 1977 |
Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism.
Topics: Amniotic Fluid; Animals; Body Weight; Cleft Palate; Dronabinol; Drug Interactions; Female; Fetal Death; Fetus; Gestational Age; Maternal-Fetal Exchange; Mice; Phenobarbital; Placenta; Pregnancy; Proadifen; Teratogens | 1977 |
Metabolic fate and disposition of 14C-labeled methyl n-butyl ketone in the rat.
Topics: Animals; Ketones; Methyl n-Butyl Ketone; Phenobarbital; Proadifen; Rats; Tissue Distribution | 1977 |
Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system.
Topics: Animals; Benserazide; Biotransformation; Cobalt; Cysteine; Glutathione; Humans; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Tyrosine | 1976 |
Hexobarbital sleeping time and drug metabolism in rats with ligated bile ducts--a lack of correlation.
Topics: Animals; Bile Ducts; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Proadifen; Protein Binding; Rats; Sleep; Thiopental; Time Factors; Zoxazolamine | 1976 |
A new class of inhibitory cytochrome P-450 complexes formed during metabolism: a comparison with amphetamine and SKF 525-A type complexes.
Topics: Amphetamines; Aniline Compounds; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Microsomes, Liver; Phenobarbital; Proadifen; Protein Binding; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1976 |
Insect cytochrome P-450.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Houseflies; Membranes; Microsomes; Naphthalenes; Phenobarbital; Proadifen; Protein Binding; Spectrophotometry; Subcellular Fractions | 1976 |
Enzyme induction by repeated adminstration of tetrachlorvinphos in rats.
Topics: Aminopyrine; Animals; Cholinesterases; Dealkylation; Enzyme Induction; In Vitro Techniques; Inactivation, Metabolic; Insecticides; Male; Microsomes, Liver; Phenobarbital; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Proadifen; Rats; Tetrachlorvinphos; Time Factors | 1976 |
Effects of alteration of hepatic microsomal enzyme activity on liver blood flow in the rat.
Topics: Animals; Benzopyrenes; Cardiac Output; Enzyme Induction; Hemodynamics; Liver Circulation; Male; Methylcholanthrene; Microsomes, Liver; Microspheres; Phenobarbital; Proadifen; Rats; Zoxazolamine | 1976 |
Determination of halothane-induced sleeping time in the rat: effect of prior administration of centrally active drugs.
Topics: Animals; Bemegride; Brain Chemistry; Circadian Rhythm; Drug Interactions; Female; Halothane; Injections, Intraventricular; Liver; Pentobarbital; Phenobarbital; Proadifen; Rats; Seizures; Sleep; Time Factors | 1976 |
Studies on the relationship between induction of drug-metabolizing enzymes, liver enlargement and ascorbic acid excretion in rodents.
Topics: Animals; Ascorbic Acid; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucuronates; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Proadifen; Rats; Transcription, Genetic; Uracil; Uracil Nucleotides | 1976 |
Interactions between ketamine and other drugs.
Topics: Animals; Autonomic Agents; Drug Interactions; Female; Hypnotics and Sedatives; Ketamine; Male; Morphine; Phenobarbital; Proadifen; Rats; Tranquilizing Agents | 1975 |
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Histidine; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Proadifen; Salmonella typhimurium; Time Factors; Valerates | 1975 |
The effect of caffeine on barbiturate sleeping time and brain level.
Topics: Aminopyrine N-Demethylase; Analysis of Variance; Animals; Barbiturates; Brain Chemistry; Caffeine; Drug Interactions; Hexobarbital; Liver; Male; Morphine Derivatives; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sleep; Time Factors | 1975 |
Comparisons of the formation of cytochrome P-450 complexes absorbing at 455 nm in rabbit and rat microsomes.
Topics: Amphetamine; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Dextropropoxyphene; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Proadifen; Rabbits; Rats | 1975 |
Effect of repeated exposure to aniline, nitrobenzene, and benzene on liver microsomal metabolism in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzene; Depression, Chemical; Fever; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitrobenzenes; Oxidoreductases; Phenacetin; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical | 1975 |
3-Chloro-p-toluidine: effects of lethal doses in rats and cats.
Topics: Acidosis; Animals; Blood Pressure; Carbon Dioxide; Cats; In Vitro Techniques; Male; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Regional Blood Flow; Respiration; Toluidines | 1975 |
Metabolism of papaverine. III. Effect of phenobarbital, 3-methylcholanthrene and SKF 525-A pre-treated in vivo and in vitro.
Topics: Aminopyrine N-Demethylase; Animals; Bile; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases, O-Demethylating; Papaverine; Phenobarbital; Proadifen; Rats | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
Influence of methylxanthines on aniline disappearance and metabolism in rats.
Topics: Aniline Compounds; Aniline Hydroxylase; Animals; Caffeine; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Rats; Tea; Theobromine; Xanthines | 1975 |
The rate of aniline metabolism in vivo in rats exposed to aniline and drugs.
Topics: Aniline Compounds; Aniline Hydroxylase; Animals; Barbiturates; Benzopyrenes; Kinetics; Liver; Male; Microsomes; Microsomes, Liver; Phenacetin; Phenobarbital; Proadifen; Rats; Time Factors | 1975 |
Effect of food deprivation, phenobarbital, and SKF-525A on teratogenicity induced by 2-sec-butyl-4,6-dinitrophenol (dinoseb) and on disposition of [14C]dinoseb in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Water; Body Weight; Bone and Bones; Dinitrophenols; Female; Fetal Resorption; Food Deprivation; Gestational Age; Mice; Phenobarbital; Pregnancy; Proadifen; Teratogens; Time Factors | 1975 |
Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.
Topics: Animals; Carbon Tetrachloride; Carboxyhemoglobin; Hemoglobins; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rabbits | 1975 |
Studies on the metabolism of dimethylnitrosamine in the rat. II. The effects of phenobarbitone and 20-methylcholanthrene on the in vitro and in vivo metabolism and acute toxicity of dimethylnitrosamine in young and mature rats.
Topics: Age Factors; Aminopyrine; Aniline Hydroxylase; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sex Factors | 1975 |
Acrylonitrile biotransformation in rats, mice, and chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol, or thiosulfate.
Topics: Administration, Oral; Animals; Biotransformation; Cricetinae; Cysteine; Dimercaprol; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Mice; Nitriles; Nitrites; Phenobarbital; Proadifen; Rats; Thiocyanates; Thiosulfates; Vinyl Compounds | 1975 |
Effects of different drugs on the urinary excretion of nifurpipone (NP) and of nitrofurantoin (NTF) in the rat.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydrochlorothiazide; Male; Nitrofurans; Nitrofurantoin; Phenobarbital; Proadifen; Probenecid; Quinine; Rats; Time Factors | 1975 |
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Enzyme Induction; Hexobarbital; Hypoprothrombinemias; Liver; Male; Methaqualone; Phenobarbital; Proadifen; Prothrombin Time; Rats; Sleep; Time Factors; Warfarin | 1976 |
Theophylline metabolism by the rat liver microsomal system.
Topics: Aldehyde Oxidoreductases; Animals; Cytosol; Female; Half-Life; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Proadifen; Rats; Theophylline; Time Factors; Xanthine Oxidase | 1976 |
Pharmacological assessment of 3-tert-butylsydnone.
Topics: Anesthesia; Animals; Convulsants; Dogs; Eye; Female; In Vitro Techniques; Methacholine Compounds; Mice; Oxadiazoles; Phenobarbital; Proadifen; Rabbits; Rats; Reaction Time; Sleep; Sydnones; Time Factors; Uterus | 1976 |
Biodisposition of ketamine in the rat: self-induction of metabolism.
Topics: Analgesia; Animals; Brain; Brain Chemistry; Dealkylation; In Vitro Techniques; Ketamine; Kinetics; Male; Microsomes, Liver; Motor Activity; Phenobarbital; Proadifen; Rats; Reaction Time; Reflex; Time Factors | 1976 |
Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes.
Topics: Animals; Epoxy Compounds; Flavonoids; Male; Microsomes, Liver; Phenobarbital; Proadifen; Protein Binding; Rats; Trichloroethylene | 1976 |
The effect of phenobarbital on cyclophosphamide antitumor activity.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mice; Mice, Inbred DBA; Phenobarbital; Proadifen | 1976 |
Phenobarbital and SKF-525A on vinblastine and vincristine toxicity in mice.
Topics: Animals; Lethal Dose 50; Male; Mice; Phenobarbital; Proadifen; Vinblastine; Vincristine | 1976 |
Distribution and binding of radioactivity in the starling after intravenous administration of [14C]3-chloro-p-toluidine.
Topics: Animals; Birds; Kidney; Liver; Maleates; Pesticides; Phenobarbital; Proadifen; Protein Binding; Subcellular Fractions; Toluidines | 1976 |
Acute cytogenetic effect of benzene on rat bone marrow cells in vivo and the effect of inducers or inhibitors of drug-metabolizing enzymes.
Topics: Animals; Azo Compounds; Benzene; Benzoquinones; Bone Marrow; Bone Marrow Cells; Chi-Square Distribution; Chromosome Aberrations; Cyclohexanes; Cyclohexenes; Female; Hydroquinones; Male; Mutagenicity Tests; Mutagens; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Rats, Wistar; Sex Factors; Species Specificity | 1992 |
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ketones; Liver; Male; Methylcholanthrene; Mirex; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Sprague-Dawley; Taurolithocholic Acid | 1992 |
Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo.
Topics: 5-Aminolevulinate Synthetase; Acrolein; Allylisopropylacetamide; Animals; Chick Embryo; Cyclophosphamide; Cytochrome P-450 Enzyme System; Enzyme Induction; Gestational Age; Liver; Molecular Structure; Phenobarbital; Porphyrins; Proadifen | 1992 |
Tissue-specific expression, induction, and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily.
Topics: Amino Acid Sequence; Animals; Benzphetamine; Blotting, Western; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferricyanides; Guinea Pigs; Male; Microsomes, Liver; Molecular Sequence Data; Multigene Family; Phenobarbital; Proadifen; Strychnine | 1992 |
Effects of oxygen concentration on the metabolism of anisole homologues by rat liver microsomes.
Topics: Animals; Anisoles; Benzoflavones; In Vitro Techniques; Male; Microsomes, Liver; Oxygen; Phenobarbital; Phenyl Ethers; Proadifen; Rats; Rats, Wistar | 1992 |
Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Electrochemistry; Injections, Intraventricular; Male; Mice; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Species Specificity | 1991 |
Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; MPTP Poisoning; NADPH-Ferrihemoprotein Reductase; Pargyline; Phenobarbital; Piperazines; Piperonyl Butoxide; Proadifen; Selegiline | 1991 |
Characterization of covalent binding of [14C]-2-chloro-4-acetotoluidide to microsomes of starling liver and kidney.
Topics: Animals; Benzoflavones; Birds; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Glutathione; In Vitro Techniques; Kidney; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Protein Binding; Sulfhydryl Compounds; Toluidines | 1991 |
Metabolism of methacrylonitrile to cyanide: in vitro studies.
Topics: Animals; Biotransformation; Cyanides; Cytochrome P-450 Enzyme System; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methacrylates; Microsomes, Liver; NADP; Nitriles; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
Cocaine toxicity in cultured rat hepatocytes.
Topics: Animals; Cell Survival; Cells, Cultured; Cocaine; Cytochrome P-450 Enzyme System; Enzyme Induction; L-Lactate Dehydrogenase; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1990 |
Further studies on the high-affinity binding of 3H-alaproclate to membranes from rat liver and some other tissues.
Topics: Adrenal Glands; Alanine; Animals; Binding Sites; In Vitro Techniques; Kidney; Kinetics; Liver; Male; Membranes; Microsomes, Liver; Myocardium; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stereoisomerism; Subcellular Fractions | 1990 |
Irreversible in vivo and in vitro binding of thiabendazole to tissue protein of pregnant mice.
Topics: Animals; DNA; Female; Fetus; In Vitro Techniques; Male; Mice; Microsomes, Liver; Phenobarbital; Pregnancy; Pregnancy, Animal; Proadifen; Protein Binding; Proteins; RNA; Thiabendazole | 1986 |
Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biotransformation; Brain Chemistry; Cerebral Cortex; Dealkylation; Female; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; N-Methyl-3,4-methylenedioxyamphetamine; Neurotransmitter Agents; Phenobarbital; Proadifen; Proteins; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1989 |
In vitro and in vivo modulation of the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in hamster lung tissues.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Cricetinae; Kinetics; Lung; Male; Mesocricetus; Methylcholanthrene; Nitrosamines; Organ Culture Techniques; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Proteins; Reference Values | 1989 |
Effect in the rat of the interaction of dichloromaleic acid and carbon tetrachloride on renal and hepatic function.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Drinking; Female; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Maleates; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Water Pollutants; Water Pollutants, Chemical | 1989 |
Changes in the inducibility of a hepatic aldehyde dehydrogenase by various effectors.
Topics: Aldehyde Dehydrogenase; Animals; Cyanamide; Disulfiram; Enzyme Induction; Isoenzymes; Male; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1989 |
Effect of inhibitors of alpha-naphthylisothiocyanate-induced hepatotoxicity on the in vitro metabolism of alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Aminopyrine; Animals; Bilirubin; Biotransformation; Chromatography, Gas; Ditiocarb; Ethionamide; Hyperbilirubinemia; Imidazoles; Kinetics; Male; Methimazole; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Thiocyanates | 1985 |
Mixed-function oxidase system induction and propylene hepatotoxicity.
Topics: Alkenes; Aminopyrine N-Demethylase; Analysis of Variance; Aniline Hydroxylase; Animals; Aroclors; Atmosphere Exposure Chambers; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glucose-6-Phosphatase; Male; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1985 |
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature | 1987 |
In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Etoposide; Mice; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Proadifen; Proteins | 1987 |
Effects of alkyl phosphorothioates on the hepatic microsomal mixed-function oxidase system in rats. Inhibition of drug-metabolizing enzyme activity and selective increase of NADPH-cytochrome c reductase activity.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organothiophosphorus Compounds; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency.
Topics: Amphetamine; Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxylation; In Vitro Techniques; Male; Methamphetamine; Methimazole; Methylcholanthrene; Microsomes, Liver; Monoamine Oxidase Inhibitors; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline | 1986 |
Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity.
Topics: Animals; Enzyme Induction; Heart; Lung Diseases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mixed Function Oxygenases; Monocrotaline; Pharmaceutical Vehicles; Phenobarbital; Proadifen; Pyrrolizidine Alkaloids; Rats; Structure-Activity Relationship | 1986 |
Modulation of monocrotaline-induced hepatic genotoxicity in rats.
Topics: Animals; Butylated Hydroxyanisole; Cytochrome P-450 Enzyme System; Cytosol; Glutathione Transferase; Kinetics; Liver; Male; Microsomes, Liver; Monocrotaline; Mutagens; Phenobarbital; Plants, Toxic; Proadifen; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1987 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences.
Topics: Amphetamines; Animals; Chromatography, Gas; Female; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline; Sex Factors; Species Specificity | 1987 |
A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Hydrocarbons, Fluorinated; Liver; Liver Diseases; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1988 |
Effects of muroctasin on the activities of drug metabolizing enzymes in liver microsomes of rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Electron Transport; Female; Liver; Microsomes, Liver; NADH Dehydrogenase; Organ Size; Oxygenases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1988 |
The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450.
Topics: Animals; Cells, Cultured; Cyclosporins; Cytochrome P-450 Enzyme System; Kinetics; Macromolecular Substances; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1987 |
Proadifen-sensitive high affinity binding of 3H-alaproclate to liver membranes.
Topics: Alanine; Animals; Antidepressive Agents; Binding, Competitive; Cell Membrane; In Vitro Techniques; Kinetics; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Subcellular Fractions | 1987 |
Effect of cytochrome P-450 induction and inhibition on the antihypertensive function of the kidney.
Topics: Animals; Blood Pressure; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Hypertension, Renovascular; Hypertrophy; Hypolipidemic Agents; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Reference Values | 1987 |
Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Female; Fetal Resorption; Male; Mice; Mice, Inbred ICR; Organ Size; Phenobarbital; Pregnancy; Proadifen; Thiabendazole | 1987 |
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and Drug Induced Liver Injury; Cimetidine; Dose-Response Relationship, Drug; Insecticides; Male; Methylcholanthrene; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Plants; Proadifen; Rats; Rats, Inbred Strains | 1987 |
Destruction of cytochrome P-450 and formation of green pigments by contraceptive steroids in rat hepatocyte suspensions.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Humans; Liver; Male; Methylcholanthrene; Norethindrone; Phenobarbital; Pigments, Biological; Proadifen; Rats; Rats, Inbred F344; Steroids; Structure-Activity Relationship; Suspensions; Time Factors | 1986 |
[Effect of the induction and inhibition of liver monooxygenases on the toxic and therapeutic action of vincristine].
Topics: Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Leukemia, Experimental; Liver; Male; Mice; Mice, Inbred CBA; Oxygenases; Phenobarbital; Proadifen; Time Factors; Vincristine | 1986 |
Studies on the mechanism of interaction between methamphetamine and quinine in rats.
Topics: Animals; Carbon Tetrachloride; Drug Interactions; Hydroxylation; Male; Methamphetamine; Phenobarbital; Proadifen; Quinine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1986 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Chemical modulation of 3-methylindole toxicosis in mice: effect on bronchiolar and olfactory mucosal injury.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchi; Epithelium; Female; Flavonoids; Glutathione; Indoles; Male; Maleates; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Nasal Mucosa; Phenobarbital; Piperonyl Butoxide; Proadifen; Sex Factors; Skatole | 1986 |
1-Naphthylisothiocyanate-induced permeability of hepatic tight junctions to proteins.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cell Membrane Permeability; Horseradish Peroxidase; In Vitro Techniques; Intercellular Junctions; Liver; Male; Phenobarbital; Proadifen; Proteins; Rats; Rats, Inbred Strains; Thiocyanates | 1986 |
Cimetidine enhances and phenobarbital decreases parathion toxicity.
Topics: Animals; Cimetidine; Drug Synergism; Liver; Male; Parathion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1986 |
In vitro metabolism of ACNU, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitroso urea hydrochloride, a water-soluble antitumor nitrosourea.
Topics: Animals; Antineoplastic Agents; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Microsomes, Liver; NADP; Nimustine; Nitrosourea Compounds; Phenobarbital; Proadifen; Rats; Temperature; Time Factors | 1985 |
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
The metabolism of 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in the rat in vivo and in vitro.
Topics: Animals; Appetite Depressants; Biotransformation; Carbon Monoxide; Chromatography, Gas; Chromatography, Thin Layer; Furans; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
Effects of phenobarbital and SKF-525A on in vitro hepatic metabolism of verapamil and nifedipine.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Nifedipine; Phenobarbital; Proadifen; Rats; Rats, Inbred F344; Verapamil | 1985 |
Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate.
Topics: Animals; Disulfiram; Ethoxyquin; Glutathione; Inactivation, Metabolic; Lethal Dose 50; Lobeline; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Proadifen | 1985 |
Relation between hepatic microsomal metabolism of N-nitrosamines and cytochrome P-450 species.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1985 |
[Multicomponent detoxifying system in albino rat liver].
Topics: Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Activation; Enzyme Inhibitors; Inactivation, Metabolic; Male; Microsomes, Liver; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phenobarbital; Proadifen; Rats | 1985 |
Lack of relationship between debrisoquine 4-hydroxylation and other cytochrome P-450 dependent reactions in rat and human liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Enzyme Induction; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity | 1985 |
[Effect of phenobarbital and SKF 525-A on the toxic and therapeutic action of adriamycin in mice with Ehrlich ascites cancer].
Topics: Animals; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Drug Interactions; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Phenobarbital; Proadifen; Time Factors | 1985 |
Characterization of a microsomal fraction from rat small intestine for metabolic activation of some promutagens.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Fluorenes; Intestine, Small; Male; Microsomes; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; Phenobarbital; Proadifen; Rats | 1985 |
Studies on the distribution and covalent binding of 1,1-dichloroethylene in the mouse. Effect of various pretreatments on covalent binding in vivo.
Topics: Animals; Carbon Radioisotopes; Dichloroethylenes; Enzyme Induction; Glutathione; Hydrocarbons, Chlorinated; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Proadifen; Tissue Distribution | 1985 |
The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins.
Topics: Animals; Ascorbic Acid; Biotransformation; Cytochrome P-450 Enzyme System; Etoposide; HeLa Cells; Humans; In Vitro Techniques; Microsomes; Microsomes, Liver; NADP; Neoplasm Proteins; Nitrogen Oxides; Phenobarbital; Podophyllotoxin; Proadifen; Protein Binding; Pyridines; Rats; Rats, Inbred Strains | 1985 |
Selective inhibition of liver-cell proliferation by CFT 1201 and SKF 525 A. Studies on growth processes induced by drugs and by partial hepatectomy.
Topics: Acetamides; Animals; DNA; Female; Hepatectomy; Hexachlorocyclohexane; Liver; Microsomes, Liver; Mitosis; Organ Size; Oxidoreductases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfur; Thymidine; Toluene; Tritium | 1972 |
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats | 1973 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.
Topics: Acetates; Aniline Compounds; Animals; Calcium; Depression, Chemical; Edetic Acid; Formaldehyde; Glycols; Kinetics; Magnesium; Male; Methylation; Microsomes, Liver; NADP; Niacinamide; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Species Specificity; Stimulation, Chemical; Sulfhydryl Reagents; Swine | 1973 |
Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Charcoal; Chromatography, Gel; Chromatography, Ion Exchange; Endoplasmic Reticulum; Estradiol; Ethinyl Estradiol; Female; Hydroxylation; Male; Microsomes, Liver; NADP; Peptide Fragments; Phenobarbital; Proadifen; Protein Binding; Proteins; Rats; Serum Albumin, Bovine; Time Factors; Tritium; Trypsin | 1973 |
Letter: Some factors modifying the metabolism of AH 8165 by rat liver homogenate in vitro.
Topics: Animals; Azo Compounds; Diazepam; Imidazoles; In Vitro Techniques; Injections, Intraperitoneal; Liver; Neuromuscular Nondepolarizing Agents; Phenobarbital; Proadifen; Pyridinium Compounds; Rats; Starvation; Tubocurarine | 1973 |
Studies on the metabolism of ethynylestradiol in vitro and in vivo: the significance of 2-hydroxylation and the formation of polar products.
Topics: Animals; Carbon Monoxide; Chromatography; Chromatography, Thin Layer; Estradiol; Estrone; Ethinyl Estradiol; Glutathione; Hydroxylation; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A.
Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dealkylation; Dialysis; Dogs; Half-Life; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenacetin; Phenazines; Phenobarbital; Proadifen; Proteins | 1974 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
Oxidative metabolism of aflatoxin B1 by rat liver microsomes in vitro and its effect on lipid peroxidation.
Topics: Adenosine Diphosphate; Aflatoxins; Animals; Ascorbic Acid; Aspergillus flavus; Chromatography, Thin Layer; Edetic Acid; In Vitro Techniques; Lipid Metabolism; Lipids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Peroxides; Phenobarbital; Proadifen; Rats; Spectrophotometry, Ultraviolet | 1974 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
Dose-dependence of drug plasma level decline in dogs.
Topics: Acetates; Animals; Barbiturates; Blood Proteins; Chlorine; Chromatography, Thin Layer; Dicumarol; Dogs; Kinetics; Liver; Muscles; Phenobarbital; Phenylbutazone; Phenytoin; Proadifen; Probenecid; Receptors, Drug; Vitamin K | 1967 |
[Activation of liver dopa decarboxylase by inducers of microsomal enzymes].
Topics: Animals; Dopa Decarboxylase; Enzyme Induction; Hexachlorocyclohexane; Liver; Microsomes; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Tolbutamide | 1967 |
The biotransformation of 8-ethylthio-6-thiotheophylline sodium in vivo.
Topics: Amines; Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Dactinomycin; Depression, Chemical; Hypnotics and Sedatives; Male; Methylcholanthrene; Oils; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical; Theophylline; Time Factors | 1968 |
[On the activation of dopa decarboxylase and other cytoplasmic liver enzymes by inducers of microsomal enzymes].
Topics: Animals; Carboxy-Lyases; Dactinomycin; Dopa Decarboxylase; Enzyme Induction; Ethionine; Hexachlorocyclohexane; L-Lactate Dehydrogenase; Liver; Microsomes; Monoamine Oxidase; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Tolbutamide | 1967 |
Drug metabolism by hepatic microsomes from phenobarbital-treated or starved male and female rats in the presence of inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Female; Hexobarbital; Liver; Male; Methylation; Microsomes, Liver; Morphinans; Niacinamide; Organ Size; Phenobarbital; Proadifen; Rats; Starvation | 1971 |
N-demethylation and N-oxidation of imipramine by rat and pig liver microsomes.
Topics: Animals; Biotransformation; Dealkylation; Edetic Acid; Imipramine; In Vitro Techniques; Magnesium; Male; Microsomes, Liver; Niacinamide; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Swine | 1971 |
Studies on the irreversible binding of 14 C-CCl 4 to microsomal lipids in rats under varying experimental conditions.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine; Animals; Carbon Isotopes; Carbon Tetrachloride; Castration; Centrifugation, Density Gradient; Edetic Acid; Ethylamines; Gonads; Hydroxylation; Lipid Metabolism; Liver; Male; Malonates; Microsomes, Liver; Niacinamide; Phenobarbital; Phenols; Proadifen; Rats; Sleep; Sucrose | 1972 |
Hydroxylation of phenacetin by beagle liver microsomes.
Topics: Acetaminophen; Animals; Benzopyrenes; Dealkylation; Dogs; Hydroxylation; Kinetics; Microsomes, Liver; Phenacetin; Phenobarbital; Proadifen | 1974 |
Factors affecting the toxicity and metabolism of OMPA (octamethylpyrophosphoramide) in rats.
Topics: Age Factors; Animals; Butylene Glycols; Chlorpromazine; Cholinesterase Inhibitors; Cholinesterases; Diphosphates; Ethionine; Female; Glutethimide; Insecticides; Liver; Male; Meprobamate; Methylcholanthrene; Microsomes; Pentobarbital; Phenobarbital; Proadifen; Rats | 1967 |
The role of liver cell endoplasmic reticulum and microsomal enzymes in carbon tetrachloride toxicity: an in vivo study.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietary Proteins; Endoplasmic Reticulum; Glucose-6-Phosphatase; Male; Microscopy, Electron; Microsomes, Liver; Phenazines; Phenobarbital; Premedication; Proadifen; Rats; Starvation | 1970 |
Increased hepatic phosphoprotein phosphatase activity induced by phenobarbital and its supression by cycloheximide and SKF 525-A.
Topics: Animals; Cycloheximide; Enzyme Induction; Kinetics; Liver; Male; Phenobarbital; Phosphoproteins; Phosphoric Monoester Hydrolases; Proadifen; Rats; Time Factors | 1972 |
Interaction of modifiers of hepatic microsomal drug metabolism and the inhalation toxicity of 1,1-dichloroethylene.
Topics: Aerosols; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chlorine; Chromatography, Gas; Drug Interactions; Ethylamines; Glucose-6-Phosphatase; Hydrocarbons, Halogenated; Lung; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Proadifen; Rats; Time Factors | 1972 |
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.
Topics: Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chloromercuribenzoates; Drug Synergism; Hexobarbital; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NAD; Nitro Compounds; Oxidation-Reduction; Oxygen Consumption; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Phenols; Proadifen; Pyridines; Rats; Spectrophotometry | 1974 |
Metabolism of trichloroethylene in liver microsomes. I. Characteristics of the reaction.
Topics: Animals; Chloral Hydrate; Chloromercuribenzoates; Cyanides; Dogs; Enzymes; Ethylmaleimide; Flavin Mononucleotide; Freeze Drying; In Vitro Techniques; Iodoacetates; Ions; Liver; Methylene Blue; Microsomes; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Trichloroethylene; Vitamin K | 1965 |
Studies on the demethylation of puromycin and related compounds by liver microsomal enzymes.
Topics: Animals; In Vitro Techniques; Liver; Microsomes; NADP; Nucleosides; Phenobarbital; Proadifen; Purines; Puromycin; Rats | 1966 |
Alteration in the magnitude of induction of tyrosine transaminase by glycocorticoids. The effects of phenobarbital, o,p'DDD and beta-diethylaminoethyl diphenylpropylacetate (SKF 525A).
Topics: Animals; Depression, Chemical; Dichlorodiphenyldichloroethane; Drug Synergism; Enzyme Induction; Hydrocortisone; Liver; Male; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Time Factors; Triamcinolone; Triamcinolone Acetonide; Tritium; Tyrosine Transaminase | 1968 |
Alteration in the magnitude of induction of tyrosine transaminase by glucocorticoids. II. Effects of phenobarbital, o,p' DDD and diethylaminoethyl diphenylpropylacetate (SKF 525A) on metabolism of triamcinolone acetonide.
Topics: Adrenal Glands; Adrenalectomy; Animals; Chromatography, Thin Layer; Depression, Chemical; Dichlorodiphenyldichloroethane; Drug Synergism; Enzyme Induction; Kinetics; Liver; Male; NADP; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Time Factors; Triamcinolone Acetonide; Tritium; Tyrosine Transaminase | 1969 |
Microsomal hydroxylation of decane.
Topics: Alcohols; Alkanes; Aniline Compounds; Animals; Carbon Isotopes; Carbon Monoxide; Cattle; Chick Embryo; Columbidae; Cyanides; Fatty Acids; Glycols; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Lung; Male; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Phenobarbital; Proadifen; Rabbits; Rats | 1969 |
Influence of microsomal enzyme inducers on the reactivity of the isolated guinea pig seminal vesicle to angiotensin and tyramine.
Topics: Angiotensin II; Animals; Aspirin; Dactinomycin; DDT; Drug Antagonism; Enzyme Induction; Glutethimide; Guinea Pigs; Male; Meprobamate; Methylcholanthrene; Microsomes; Phenobarbital; Piperazines; Proadifen; Protein Biosynthesis; Seminal Vesicles; Sulfanilamides; Tyramine | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Response of female mice to anticonvulsants after pretreatment with sex steroids.
Topics: Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Drug Synergism; Female; Lynestrenol; Mestranol; Mice; Phenobarbital; Phenytoin; Proadifen | 1970 |
Studies on the induction of nitroreductase activity by DDT and phenobarbital.
Topics: Aminobenzoates; Animals; Benzoates; Cyanides; DDT; Enzyme Induction; Liver; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats; Sodium; Venoms | 1970 |
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.
Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature | 1970 |
Comparative N-demethylation of antihistaminic agents possessing dimethylaminoalkyl group by liver preparations from four animal species.
Topics: Age Factors; Animals; Castration; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Histamine H1 Antagonists; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Rabbits; Rats; Sex Factors; Species Specificity; Testosterone | 1971 |
Relationship between difference spectra and metabolism. Barbiturates, drug interaction and species difference.
Topics: Acetanilides; Acetates; Amino Alcohols; Aminopyrine; Aniline Compounds; Animals; Barbiturates; Binding Sites; Chemical Phenomena; Chemistry; Chlorpromazine; Cytochromes; Drug Antagonism; Drug Synergism; Ethanolamines; Hexobarbital; Macaca; Male; Mice; Microsomes, Liver; Pentobarbital; Phenobarbital; Proadifen; Propranolol; Protein Binding; Rats; Sleep; Species Specificity; Spectrophotometry; Thiazoles; Tremorine | 1970 |
Effect of inhibitors and inducers of drug metabolism on ethanol metabolism in vivo.
Topics: Animals; Body Weight; Ethanol; Female; Histamine H1 Antagonists; Male; Mathematics; Metabolism; Mice; Microsomes, Liver; Pentobarbital; Phenobarbital; Piperazines; Proadifen; Rats; Sleep; Species Specificity; Time Factors | 1970 |
Formation of a factor lethal for S. typhimurium TA1530 and TA1531 on incubation of aflatoxin B 1 with rat liver microsomes.
Topics: Aflatoxins; Aniline Compounds; Animals; Carbon Monoxide; Caseins; Chromatography, Thin Layer; Depression, Chemical; Diet; Male; Microsomes, Liver; NADP; Nitrogen; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1971 |
The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.
Topics: Alkaloids; Animals; Calcium; Carbon Monoxide; DDT; Diet; Kinetics; Lung; Magnesium; Manganese; Microsomes; Microsomes, Liver; Models, Biological; NADP; Niacinamide; Oxides; Oxygen; Phenobarbital; Proadifen; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1971 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport; Endoplasmic Reticulum; Ethionine; Fatty Liver; Glucose-6-Phosphatase; Histocytochemistry; Liver; Macaca; Male; Microsomes, Liver; NADP; Necrosis; Oxidoreductases; Phenazines; Phenobarbital; Proadifen; Protein Deficiency; Rats; Rats, Inbred Strains | 1972 |
Monooxygenase drug metabolizing activity in CaCl 2 -aggregated hepatic microsomes from rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Calcium Chloride; Carbon Monoxide; Chlorine; Dronabinol; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
Topics: Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Flavonoids; Hemeproteins; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital; Piperazines; Proadifen; Rats; Structure-Activity Relationship; Testosterone | 1973 |
In vitro activation of isophosphamide (NSC-109724), a new oxazaphosphorine, by rat liver microsomes.
Topics: Alkylating Agents; Alkylation; Aminopyrine; Aniline Compounds; Animals; Cyclic P-Oxides; Cyclophosphamide; Dealkylation; DNA; Enzyme Activation; Ethylamines; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; NADP; Oxazines; Oxidoreductases; Phenobarbital; Phosphoranes; Proadifen; Proteins; Rats; RNA | 1972 |
The etiology of methoxyflurane nephrotoxicity.
Topics: Animals; Fluorides; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Liver; Male; Methoxyflurane; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Osmolar Concentration; Oxalates; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1974 |
Metabolism of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284), a new non-steroidal anti-inflammatory agent, in relation to ulcerogenic activity.
Topics: Animals; Anti-Inflammatory Agents; Bile; Carboxylic Acids; Cyclohexanes; Cytosol; Female; Glucuronates; Glucuronidase; Guinea Pigs; Hydrogen-Ion Concentration; Indans; Indenes; Intestine, Small; Liver; Male; Mice; Microsomes, Liver; Peptic Ulcer; Phenobarbital; Proadifen; Rats; Tritium; Uridine Diphosphate Sugars | 1974 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; Enzymes; Glucuronates; Glutathione; Half-Life; Intestinal Absorption; Kidney; Kinetics; Liver Diseases; Metabolism; Methylcholanthrene; Mice; Models, Theoretical; Necrosis; Phenobarbital; Proadifen; Rats; Regional Blood Flow; Sulfates; Toxicology | 1974 |
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.
Topics: Administration, Oral; Alprenolol; Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Imipramine; Injections, Intravenous; Liver; Male; Methods; Metyrapone; Microsomes, Liver; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry; Time Factors; Tritium | 1974 |
Studies on the role of the liver in the metabolism of parathyroid hormone. I. Effects of partial hepatectomy and incubation of the hormone with tissue homogenates.
Topics: Adrenal Glands; Adrenalectomy; Animals; Antigens; Aprotinin; Calcium; Culture Techniques; Female; Hemorrhage; Hepatectomy; Hydrocortisone; Kidney; Liver; Male; Methylcholanthrene; Nephrectomy; Parathyroid Glands; Parathyroid Hormone; Phenobarbital; Phosphorus; Proadifen; Radioimmunoassay; Rats; Spleen | 1972 |
Comparative studies on hepatic N- and O-demethylation.
Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide | 1972 |
The effect of prior treatment with phenobarbitone, dicophane (DDT) and beta-diethylaminoethyl phenylpropyl acetate (SKF 525A) on experimental intoxication of sheep with the plant Myoporum deserti Cunn.
Topics: Animals; Bilirubin; Biopsy; DDT; Edema; Eosinophils; Gallbladder; Gastrointestinal Hemorrhage; Ischemia; Kidney; Leukocytes; Liver; Male; Microsomes, Liver; Phenobarbital; Plant Extracts; Plant Poisoning; Premedication; Proadifen; Sesquiterpenes; Sheep; Sheep Diseases | 1973 |
Biotransformation of nitroglycerin by organic nitrate reductase.
Topics: Animals; Biotransformation; Enzyme Activation; Glucosephosphate Dehydrogenase; Glutathione; Kinetics; Liver; Male; Nitrates; Nitroglycerin; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1972 |
Genetic influence upon phenobarbital-induced increase in rat liver supernatant aldehyde dehydrogenase activity.
Topics: Aldehyde Oxidoreductases; Animals; Brain; Enzyme Induction; Female; Genes, Dominant; Genotype; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital; Proadifen; Protein Denaturation; Rats; Rats, Inbred ACI; Rats, Inbred BN; Rats, Inbred Strains; Species Specificity; Structure-Activity Relationship; Subcellular Fractions | 1972 |
Metabolism of erythropoietin by isolated perfused livers of dogs treated with SKF 525-A.
Topics: Animals; Depression, Chemical; Dogs; Erythropoietin; Female; Hypoxia; Liver; Perfusion; Phenobarbital; Proadifen; Time Factors | 1972 |
Effect of phenobarbital and SKF 525A on the toxicity, elimination and metabolism of cyclophosphamide in newborn mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Carbon Isotopes; Cyclophosphamide; Drug Synergism; Half-Life; Mice; Phenobarbital; Proadifen | 1973 |
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; Hydrocarbons, Halogenated; Liver; Liver Diseases; Macromolecular Substances; Male; Maleates; Mice; Microsomes, Liver; Necrosis; Nitriles; Phenobarbital; Piperonyl Butoxide; Proadifen; Protein Binding; Pyrazoles; Rats | 1973 |
Effects of dosage, phenobarbital, and 2-diethylaminoethyl-2,2-diphenylvalerate on the binding of cyclophosphamide and-or its metabolites to the DNA, RNA, and protein of the embryo and liver in pregnant mice.
Topics: Animals; Cyclophosphamide; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Liver; Mice; Phenobarbital; Pregnancy; Pregnancy, Animal; Proadifen; Protein Binding; RNA; Tritium | 1973 |
Changes of fluoride content in bone: an index of drug defluorination in vivo.
Topics: Anesthetics; Animals; Biotransformation; Body Weight; Bone and Bones; Chlorine; Drug Interactions; Ethanol; Ethers; Female; Fluoridation; Fluorides; Fluorine; Furans; Halothane; Hydrocarbons, Halogenated; Lethal Dose 50; Male; Methoxyflurane; Methyl Ethers; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnancy; Proadifen; Rats; Time Factors | 1973 |
Uptake and elimination of methoxyflurane as influenced by enzyme induction in the rat.
Topics: Anesthesia, Inhalation; Animals; Chlorine; Drug Interactions; Enzyme Induction; Fluorides; Kidney; Liver; Male; Methoxyflurane; Microsomes, Liver; Phenobarbital; Proadifen; Radioisotopes; Rats; Time Factors | 1973 |
Modification of acrylamide neuropathy in rats by selected factors.
Topics: Acrylamides; Adrenal Glands; Adrenalectomy; Age Factors; Animals; DDT; Enzyme Induction; Hexobarbital; Hydrocortisone; In Vitro Techniques; Liver; Male; Microsomes, Liver; Motor Activity; Myelin Sheath; Neurons; Oxidoreductases; Peripheral Nerves; Phenobarbital; Proadifen; Rats; Thiamine Deficiency; Time Factors; Vitamin B 6 Deficiency | 1973 |
Propanil (3,4-dichloropropionanilide)-induced methemoglobin formation in mice in relation to acylamidase activity.
Topics: Amidohydrolases; Anilides; Aniline Compounds; Animals; Cresols; Cyanosis; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Herbicides; Liver; Male; Methemoglobin; Methemoglobinemia; Organophosphorus Compounds; Phenobarbital; Proadifen; Propanil; Rats; Reflex; Time Factors | 1973 |
Metabolism of dimethoxymethylphenobarbital in mice. relationship between brain phenobarbital levels and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Barbiturates; Brain Chemistry; Chromatography, Gas; Mice; Phenobarbital; Proadifen; Time Factors | 1973 |
The disposition of propranolol. IV. A dominant role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver.
Topics: Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Liver; Male; Models, Biological; Perfusion; Phenobarbital; Proadifen; Propranolol; Rats; Time Factors | 1973 |
Microsomal drug oxidation. Function, induction, and inhibition of the cytochrome P450-system.
Topics: Animals; Benzopyrenes; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Depression, Chemical; Enzyme Induction; Humans; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Proadifen; Rabbits; Rats; Spectrophotometry | 1973 |
Species differences in induction and inhibition of liver isocarboxazid hydrolase.
Topics: Aging; Animals; Animals, Newborn; Enzyme Induction; Female; Guinea Pigs; Hydrolases; In Vitro Techniques; Isocarboxazid; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Pregnancy; Proadifen; Rabbits; Rats; Species Specificity | 1973 |
Some spectral properties of cytochrome P-450 from microsomes isolated from control, phenobarbital- and naphthalene-treated houseflies.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Houseflies; Ligands; Microsomes; Naphthalenes; Nucleic Acid Conformation; Phenobarbital; Proadifen; Protein Conformation; Spectrophotometry; Spectrophotometry, Ultraviolet | 1973 |
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Proadifen; Protein Binding; Pyrazoles; Rats; Sex Factors; Statistics as Topic | 1973 |
Effects of dietary protein quality on drug metabolism in the rat.
Topics: Anesthesia; Aniline Compounds; Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Dealkylation; Dietary Proteins; Drug Synergism; Glutens; Hexobarbital; Hydroxylation; Liver; Male; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Proadifen; Proteins; Rats; Time Factors | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Drug Antagonism; Half-Life; Hydrocarbons, Brominated; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Necrosis; Phenobarbital; Proadifen; Rats; Time Factors | 1973 |
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Paralysis; Phenobarbital; Proadifen; Respiration; Sleep; Time Factors; Zoxazolamine | 1973 |
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; Hydrocarbons, Halogenated; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Necrosis; Phenobarbital; Proadifen; Protein Binding; Proteins; Rats; Time Factors | 1973 |
Effects of drug pretreatment on antipyrine levels in blood and tissues: an example of multiple drug interactions.
Topics: Animals; Antipyrine; Brain; Brain Chemistry; Drug Interactions; Enzyme Induction; Half-Life; Kinetics; Liver; Male; Phenobarbital; Phenytoin; Proadifen; Rats; Time Factors | 1973 |
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Cholinesterases; Clinical Enzyme Tests; Diagnosis, Differential; Ethionine; Fatty Liver; Fructose-Bisphosphate Aldolase; Fructosephosphates; Necrosis; Phenobarbital; Proadifen; Rats; Thioacetamide | 1973 |
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxylic Acids; Griseofulvin; Heme; Humans; Hydrocortisone; Levulinic Acids; Liver; Male; Mental Disorders; Microsomes; Phenobarbital; Phenylbutazone; Porphyrias; Proadifen; Protein Precursors; Pyridines; Rats; Starvation; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
The effect of carbon disulphide used in combination with carbon tetrachloride on the toxicity of the latter drug for sheep.
Topics: Aminopyrine; Animals; Biopsy; Carbon Disulfide; Carbon Radioisotopes; Carbon Tetrachloride; DDT; Diet; Drug Combinations; Fasciola hepatica; Liver; Male; Microsomes, Liver; Phenobarbital; Proadifen; Sheep | 1973 |
The metabolic fate of hexobarbital in the rat.
Topics: Animals; Bile; Carbon Radioisotopes; Countercurrent Distribution; Feces; Half-Life; Hexobarbital; Hydroxylation; In Vitro Techniques; Ketones; Kidney; Kinetics; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry, Ultraviolet; Time Factors; Urea | 1974 |
Biliary excretion of metabolities of bromobenzene.
Topics: Alkylation; Animals; Benzene; Bile; Bile Ducts; Carbon Radioisotopes; Hydrocarbons, Brominated; Liver; Male; Phenobarbital; Proadifen; Rats; Time Factors | 1974 |
Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics.
Topics: Age Factors; Androstanes; Animals; Carbon Monoxide; Carbon Radioisotopes; Castration; Estradiol; Female; Hydroxysteroids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Sex Factors; Steroid Hydroxylases; Sulfuric Acids; Testosterone | 1974 |
Marijuana responses in rats: influence of castration or testosterone.
Topics: Animals; Behavior, Animal; Cannabis; Castration; Enzyme Induction; Female; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Testis; Testosterone | 1974 |
On the cerebral accumulation of ketamine and the relationship between metabolism of the drug and its pharmacological effects.
Topics: Animals; Brain; Cerebral Cortex; Depression, Chemical; Dialysis; Dinitrophenols; Half-Life; In Vitro Techniques; Iodoacetates; Ketamine; Liver; Male; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Subcellular Fractions | 1974 |
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
Topics: Animals; Benzene Derivatives; Biotransformation; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cysteine; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Hydrocarbons, Brominated; In Vitro Techniques; Liver; Male; Maleates; Microsomes, Liver; Necrosis; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats | 1974 |
Imipramine and chlorpromazine in hepatic microsomal systems.
Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Microsomes, Liver; Phenobarbital; Proadifen; Proteins; Spectrophotometry, Ultraviolet | 1974 |
Effect of drug pretreatment on CBrCl3-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver Injury; Chloroform; Drug Interactions; Fatty Liver; Hydrocarbons, Halogenated; Lipid Metabolism; Male; Microsomes, Liver; Necrosis; Peroxides; Phenobarbital; Phenylenediamines; Proadifen; Rats; Spectrophotometry, Ultraviolet; Time Factors; Triglycerides | 1974 |
Effects of phenobarbital and SKF 525A pretreatment, sex, liver injury, and vehicle on delta9-tetrahydrocannabinol toxicity.
Topics: Animals; Brain Chemistry; Cannabis; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dronabinol; Feces; Male; Mice; Pharmaceutical Vehicles; Phenobarbital; Proadifen; Sex Factors; Thiocyanates | 1974 |
Modifications of the in vitro metabolism of the hepatotoxic pyrrolizidine alkaloid, monocrotaline.
Topics: Animals; Biotransformation; Chloramphenicol; In Vitro Techniques; Male; Microsomes, Liver; Oxides; Phenobarbital; Proadifen; Pyrrolizidine Alkaloids; Rats | 1974 |
The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors.
Topics: Acetanilides; Animals; Ascorbic Acid; Azides; Bile Pigments; Carbon Monoxide; Chickens; Chloramphenicol; Culture Techniques; Cyanides; Cycloheximide; Dactinomycin; Erythrocytes; Ethylmaleimide; Female; Heme; Hydrogen Peroxide; Macrophages; Metabolism; Microscopy, Phase-Contrast; Mitomycins; Phagocytosis; Phenobarbital; Proadifen; Quinacrine; Spectrophotometry; Spectrum Analysis; Stimulation, Chemical; Triazoles | 1970 |
Excretion in urine of metabolites of glyceryl trinitrate (trinitrin) in rabbits.
Topics: Animals; Chromatography, Thin Layer; Nitroglycerin; Phenobarbital; Proadifen; Rabbits; Time Factors | 1969 |
The metabolic fate of nitroglycerin (trinitrin) in relation to its vascular effects.
Topics: Adipose Tissue; Administration, Oral; Animals; Blood Pressure; Blood Vessels; Dogs; Erythrocytes; Injections, Intravenous; Kidney; Liver; Lung; Muscles; Myocardium; Nitrates; Nitroglycerin; Phenobarbital; Proadifen; Rabbits | 1970 |
Effect of phenobarbital and SKF 525-A on the teratogenicity of cyclophosphamide in mice.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Cyclophosphamide; Eye Abnormalities; Female; Hydronephrosis; Limb Deformities, Congenital; Liver; Mice; Phenobarbital; Pregnancy; Proadifen; Ribs; Time Factors | 1968 |
The effect of phenobarbital or 2-diethylaminoethyl-2,2-diphenylvalerate on the activation of cyclophosphamide in vivo.
Topics: Animals; Biological Assay; Cyclophosphamide; Drug Interactions; Drug Synergism; Kinetics; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Phenobarbital; Proadifen; Spectrophotometry; Time Factors | 1972 |
Amphetamine aggregation effect in mice under conditions of altered microsomal enzymes.
Topics: Amphetamine; Animals; Behavior, Animal; Chlordan; Crowding; Drug Synergism; Enzyme Induction; Hexobarbital; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Microsomes; Phenobarbital; Proadifen; Sleep; Social Isolation | 1972 |
The effect of experimental local inflammation on the action of barbiturates in rat.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Carrageenan; Charcoal; Chlordan; Enzyme Induction; Gossypium; Hexobarbital; Inflammation; Injections, Subcutaneous; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sleep; Time Factors; Yeasts | 1972 |
Microsomal enzymes and potentiation of tyramine pressor response.
Topics: Animals; Blood Pressure; Drug Synergism; Enzyme Induction; In Vitro Techniques; Isoniazid; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Phenelzine; Phenobarbital; Proadifen; Rats; Subcellular Fractions; Time Factors; Tyramine | 1972 |
Effect of pretreatment with spironolactone, phenobarbital or -diethylaminoethyl diphenylpropylacetate (SKF 525-A) on tritium levels in blood, heart and liver of rats at various times after administration of ( 3 H)digitoxin.
Topics: Animals; Depression, Chemical; Digitoxin; Kinetics; Liver; Male; Myocardium; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spironolactone; Stimulation, Chemical; Tritium | 1972 |
Studies on drug metabolism. 13. Possible role of liver microsomal cytochrome P-450 in the oxidative N-demethylation of p-substituted dimethylaniline, N-methyl-N-alkylaniline and N-methyl-N-acylaniline derivatives.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Male; Methylation; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1972 |
The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Mice; Microsomes, Liver; Necrosis; Oils, Volatile; Phenobarbital; Proadifen; Water | 1972 |
A correlation between cyclophosphamide induced leukopenia in mice and the presence of alkylating metabolites.
Topics: Alkylating Agents; Animals; Cyclophosphamide; Female; In Vitro Techniques; Kinetics; Leukocyte Count; Leukopenia; Liver; Mice; Phenobarbital; Proadifen; Stimulation, Chemical | 1972 |
Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Lethal Dose 50; Liver; Male; Microsomes, Liver; Phenobarbital; Proadifen; Pyrroles; Pyrrolizidine Alkaloids; Rats; Sucrose; Tissue Extracts | 1972 |
The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver.
Topics: 5-Aminolevulinate Synthetase; Amides; Animals; Bilirubin; Catalase; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucose; Half-Life; Heme; Liver; Microsomes, Liver; Phenobarbital; Porphyrins; Proadifen; Rats | 1972 |
Biliary excretion of 3-methylcholanthrene as controlled by its metabolism.
Topics: Animals; Benzopyrenes; Bile; Depression, Chemical; Enzyme Induction; Female; Half-Life; Injections, Intravenous; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Stimulation, Chemical; Time Factors; Tritium | 1972 |
Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.
Topics: Acetamides; Allyl Compounds; Amides; Amino Acids; Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Iron Isotopes; Levulinic Acids; Ligases; Liver; Male; Microsomes, Liver; Phenobarbital; Pigments, Biological; Porphyrias; Proadifen; Rats; Tritium | 1971 |
Metabolic factors which influence triethyl phosphate-induced narcosis in rats.
Topics: Age Factors; Anesthesia; Animals; Brain; Brain Chemistry; Chromatography, Gas; Colorimetry; Drug Interactions; Female; Liver; Male; Organophosphorus Compounds; Phenobarbital; Proadifen; Rats; Sleep; Time Factors | 1971 |
Bromobenzene metabolism and hepatic necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Drug Synergism; Liver; Male; Microsomes, Liver; Necrosis; Organ Specificity; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains | 1971 |
Effects of phenobarbital or SKF 525A pretreatment on diphenylhydantoin disposition in pregnant mice.
Topics: Abnormalities, Drug-Induced; Adipose Tissue; Amniotic Fluid; Animals; Brain Chemistry; Carbon Isotopes; Chromatography, Thin Layer; Feces; Female; Fetus; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred Strains; Muscles; Phenobarbital; Phenytoin; Placenta; Pregnancy; Pregnancy, Animal; Proadifen; Time Factors | 1971 |
The effect of microsomal enzyme stimulants and depressants on amphetamine aggregation toxicity in mice.
Topics: Amphetamine; Animals; Benzopyrenes; Carbon Tetrachloride; Chlordan; Enzyme Repression; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Proadifen | 1969 |
Differences in the oxidative metabolism of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Oxidoreductases; Pentobarbital; Phenobarbital; Proadifen; Rats; Sex Factors; Starvation; Thyroxine; Zoxazolamine | 1969 |
[Analgesic effect of 2-methylaminoethyl 2,3-dihydrobenzofuran (EPS-4032); mode of action in mice].
Topics: 5-Hydroxytryptophan; Aminopyrine; Analgesics; Animals; Benzofurans; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Drug Tolerance; Lethal Dose 50; Levallorphan; Male; Mice; Morphine; Nialamide; Pargyline; Phenobarbital; Proadifen; Reserpine; Tetrabenazine; Time Factors | 1971 |
N-demethylation of p-(N1-methylhydrazion methyl)-N-isopropyl benzamide (procarbazine), a cytostatically active methylhydrazine derivative, in the intact rat and in the isolated perfused rat liver.
Topics: Animals; Benzoates; Carbon Dioxide; Carbon Isotopes; Hydrazines; Liver; Male; Methylation; Methylcholanthrene; Oxidation-Reduction; Perfusion; Phenobarbital; Proadifen; Rats | 1969 |
Effect of microsomal enzyme modifiers on toxicity and therapeutic activity of cyclophosphamide in mice.
Topics: Animals; Cyclophosphamide; Environment; Female; Hardness; Leukemia L1210; Mice; Phenobarbital; Proadifen; Wood | 1969 |
Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes.
Topics: Adjuvants, Anesthesia; Aniline Compounds; Animals; Anisoles; Blood Proteins; Body Weight; Carbon Disulfide; Carbon Isotopes; Cycloheximide; Cytochromes; DNA; Fasting; Heme; Injections, Intraperitoneal; Leucine; Lipids; Liver; Liver Glycogen; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Organ Size; Phenobarbital; Proadifen; Protein Biosynthesis; Proteins; Rats; RNA; Spectrophotometry; Sucrose; Time Factors | 1969 |
Effect of drug pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver microsomal lipids.
Topics: Animals; Carbon Tetrachloride Poisoning; Centrifugation; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Spectrophotometry | 1970 |
Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes.
Topics: Alkylation; Aniline Compounds; Animals; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Stereoisomerism | 1970 |
The effect of SKF 525A on the distribution of carbon tetrachloride in rats.
Topics: Adipose Tissue; Administration, Oral; Animals; Brain Chemistry; Carbon Isotopes; Carbon Tetrachloride; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Absorption; Liver; Male; Muscles; Phenobarbital; Proadifen; Rats; Solubility; Time Factors; Toluene | 1970 |
Further evidene on the nature of microsomal metabolism of procarbazine and related alkyhydrazines.
Topics: Animals; Benzoates; Carbon Monoxide; Cytochromes; Enzyme Induction; Hydrazines; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen; Oxidoreductases; Oxygen; Phenobarbital; Proadifen; Rats; Sheep; Swine; Trypsin | 1970 |
Relations between barbiturate brain levels and sleeping time in various experimental conditions.
Topics: Amphetamine; Animals; Brain Chemistry; Chlorpromazine; DDT; Dextroamphetamine; Diazepam; Female; Pentobarbital; Phenobarbital; Proadifen; Rats; Sleep; Time Factors | 1970 |
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fetal Diseases; Fetus; Mice; Phenobarbital; Phenytoin; Pregnancy; Pregnancy, Animal; Proadifen; Stimulation, Chemical | 1970 |
The role of the hepatic endoplasmic reticulum in the biliary excretion of foreign compounds by the rat. The effect of phenobarbitone and SKF 525-A (diethylaminoethyl diphenylpropylacetate).
Topics: Animals; Bile; Biphenyl Compounds; Carbon Isotopes; Diethylstilbestrol; Endoplasmic Reticulum; Female; Glucuronates; Indocyanine Green; Liver; Phenobarbital; Phenolphthaleins; Proadifen; Rats; Succinates; Sulfathiazoles | 1970 |
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chlorides; Chromatography, Paper; Dealkylation; Desipramine; Ethylamines; Imipramine; Liver; Magnesium; Male; Metabolism; Methylation; Oxidation-Reduction; Oxides; Phenobarbital; Proadifen; Rats; Valerates | 1970 |
Aminopyrine demethylase. Kinetic evidence for multiple microsomal activities.
Topics: Aminopyrine; Animals; Carbon Monoxide; Chromatography, Thin Layer; Cytochromes; Dealkylation; Enzyme Induction; Ethionine; Goats; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rats; Spectrophotometry; Stimulation, Chemical; Sulfites | 1970 |
Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. I. Experiments in vivo and with isolated perfused livers.
Topics: Alcohols; Animals; Benzyl Compounds; Bile; Bile Acids and Salts; Biliary Fistula; Chromatography, Thin Layer; Desipramine; Glucuronates; Imines; Imipramine; Injections, Intravenous; Intestine, Small; Kinetics; Laparotomy; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Time Factors | 1970 |
Effects of various drugs on the uterotropic response to mestranol and norethynodrel in the rat.
Topics: Aminosalicylic Acids; Animals; Chlorpromazine; Drug Synergism; Female; Imipramine; Mestranol; Norethynodrel; Organ Size; Phenobarbital; Phenylbutazone; Phenytoin; Proadifen; Rats; Scopolamine; Tolbutamide; Uterus | 1971 |
Induction and inhibition of in vivo glucuronidation of apomorphine in mice.
Topics: Animals; Apomorphine; Dactinomycin; Enzyme Induction; Estradiol; Female; Glucuronates; Male; Mice; Pentobarbital; Phenobarbital; Proadifen; Sleep; Testosterone; Time Factors | 1971 |
Studies on drug metabolism. XI. Metabolic interaction of aniline and phenylbutazone on the liver microsomal drug metabolizing enzymes.
Topics: Aniline Compounds; Animals; Depression, Chemical; Female; Hydro-Lyases; Injections, Intraperitoneal; Male; Microsomes, Liver; Phenobarbital; Phenylbutazone; Proadifen; Rats; Stimulation, Chemical | 1971 |
Effect of phenobarbital and SKF 525A on placental transfer of cyclophosphamide in mice.
Topics: Animals; Carbon Isotopes; Chromatography, Paper; Cyclophosphamide; Embryo, Mammalian; Feces; Female; Maternal-Fetal Exchange; Mice; Phenobarbital; Placenta; Pregnancy; Proadifen; Time Factors | 1971 |
The metabolism of styrene in the rat and the stimulatory effect of phenobarbital.
Topics: Animals; Biotransformation; Enzyme Induction; Female; Glucuronates; Glycols; Glyoxylates; Hippurates; Lethal Dose 50; Mandelic Acids; Oxides; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Styrenes | 1971 |
Factors influencing dimethoate and triethyl phosphate-induced narcosis in rats and mice.
Topics: Age Factors; Anesthesia; Animals; Brain; Cholinesterase Inhibitors; Female; Glycolates; Insecticides; Male; Mice; Nitrophenols; Phenobarbital; Phosphoric Acids; Proadifen; Rats; Reflex; Salivation; Sex Factors | 1971 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Phenothiazines; Proadifen; Puromycin; Urethane | 1971 |
Effects of various chemical agents on drug metabolism and cholesterol biosynthesis.
Topics: Acetanilides; Acetates; Aminopyrine; Animals; Anticholesteremic Agents; Benzopyrenes; Carbon Isotopes; Chloramphenicol; Cholesterol; Depression, Chemical; Drug Synergism; Ethers; Ethylamines; Hexobarbital; Insecticides; Iproniazid; Liver; Male; Mevalonic Acid; Microsomes; Nitrophenols; Phenobarbital; Proadifen; Rabbits; Rats; Sleep; Time Factors | 1968 |
The prolongation of reserpine-induced cardiac norepinephrine depletion by metabolic inhibitors.
Topics: Adrenal Medulla; Amides; Animals; Dactinomycin; Depression, Chemical; Drug Synergism; Heart; In Vitro Techniques; Liver; Male; Myocardium; Norepinephrine; Perfusion; Phenobarbital; Proadifen; Rats; Reserpine; Sulfhydryl Compounds; Tritium | 1968 |
Tolerance to morphine in the white mice.
Topics: Aminopyrine; Animals; Behavior, Animal; Body Temperature; Body Weight; Drug Tolerance; Mice; Morphine; Phenobarbital; Proadifen; Sodium Salicylate | 1968 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
Alcohol metabolism: role of microsomal oxidation in vivo.
Topics: Alcohols; Animals; Carbon Isotopes; Ethanol; Methanol; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Proadifen; Rats | 1969 |
Stereoselective metabolism of the enantiomers of hexobarbital.
Topics: Animals; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Sleep; Stereoisomerism; Time Factors | 1969 |
Potentiation and inhibition of alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis.
Topics: Animals; Chlorpromazine; Cholestasis; Dactinomycin; Ethionine; Hyperbilirubinemia; In Vitro Techniques; Mice; Microsomes; Phenobarbital; Proadifen; Thiocyanates | 1965 |
[Services and perspectives of metabolic research on certain exogenous substances endowed with pharmacological activity].
Topics: Animals; Carbon Tetrachloride Poisoning; Humans; Microsomes; Pentobarbital; Pharmacology; Phenobarbital; Phenytoin; Proadifen; Rats; Substance-Related Disorders | 1965 |
Phenobarbital-induced fine structural changes in rat liver.
Topics: Animals; Hepatomegaly; Liver Diseases; Phenobarbital; Proadifen; Rats | 1966 |
Effect of whole-body irradiation on barbiturate metabolism in successive generations of mice.
Topics: Animals; Genetics; Liver; Mice; Microsomes; Pentobarbital; Phenobarbital; Proadifen; Radiation Effects | 1966 |
Inhibition of drug metabolism. IV. Induction of drug metabolism by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethylamine HBr (Lilly 18947) and the effect of induction on the inhibitory properties of SKF 525-A
Topics: Animals; Antimetabolites; Enzymes; Hexobarbital; Male; Microsomes; Morphine; Phenobarbital; Proadifen; Proteins; Rats | 1966 |
Methylene blue and erythrocytes in the living animal. Contribution to the toxicology of methylene blue and formation of Heinz bodies.
Topics: Animals; Cats; Dogs; Erythrocytes; Guinea Pigs; Heinz Bodies; Methylene Blue; Mice; Phenobarbital; Proadifen; Rabbits; Rats | 1967 |
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Dactinomycin; Dogs; Ethers; Ethyl Ethers; Ethylamines; Female; Male; Methylcholanthrene; Mice; Nitrous Oxide; Phenobarbital; Proadifen | 1967 |
Protective effect of phenobarbital and SKF 525a on the acute ethanol-induced fatty liver.
Topics: Animals; Antidotes; Ethanol; Fatty Liver; Liver; Male; Microsomes; Phenobarbital; Proadifen; Rats; Triglycerides | 1967 |
The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes.
Topics: Aerobiosis; Animals; Metronidazole; Metyrapone; Phenobarbital; Proadifen; Species Specificity; Time Factors; Trypanosoma cruzi | 1983 |
Alterations in tissue distribution of chlordecone (kepone) in the rat following phenobarbital or SKF-525A administration.
Topics: Animals; Chlordecone; Drug Synergism; Insecticides; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Tissue Distribution | 1983 |
Disposition of medroxyprogesterone acetate and drug metabolism activity.
Topics: Animals; Brain; Inactivation, Metabolic; Intestinal Mucosa; Liver; Lung; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.
Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine | 1984 |
In vivo metabolism of 11-hydroxy-delta-tetrahydrocannabinol to two carboxylic acids and the effects of SKF 525-A, cobaltous chloride and phenobarbital on their formation in rats.
Topics: Animals; Carboxylic Acids; Cobalt; Dronabinol; Liver; Phenobarbital; Proadifen; Rats | 1980 |
Quantitative correlation between the metabolism and the mutagenic activity of N-nitrosopyrrolidine.
Topics: Animals; Biotransformation; Butylene Glycols; Cobalt; Hydroxylation; Male; Microsomes, Liver; Mutagenicity Tests; N-Nitrosopyrrolidine; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1984 |
Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A.
Topics: Animals; Aroclors; Benzene; Bone Marrow; Cell Nucleus; Chlorodiphenyl (54% Chlorine); Drug Interactions; Female; Male; Metaphase; Methylcholanthrene; Mice; Mutagenicity Tests; Mutagens; Mutation; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Sex Factors; Toluene | 1984 |
Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital-type and 3-methylcholanthrene-type polychlorinated biphenyls in rats.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Metabolism of valproic acid by hepatic microsomal cytochrome P-450.
Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Oxygen Isotopes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Valproic Acid | 1984 |
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
Topics: Animals; Carnitine; Fasting; Male; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Proadifen; Seizures; Valproic Acid | 1984 |
Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes.
Topics: Animals; Carcinogens; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 1984 |
[Liver mono-oxygenases and the pharmacodynamics of carminomycin and rubomycin].
Topics: Animals; Carubicin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Mice, Inbred CBA; Oxygenases; Phenobarbital; Proadifen; Sleep; Time Factors | 1984 |
Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytosol; Epoxide Hydrolases; Glutathione; Glutathione Transferase; In Vitro Techniques; Lung; Male; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Naphthalenes; Phenobarbital; Piperonyl Butoxide; Proadifen; Proteins | 1984 |
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot Deformities, Congenital; Hindlimb; Imidazoles; Methylcholanthrene; Mice; Phenobarbital; Pregnancy; Proadifen; Species Specificity | 1984 |
Protective effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate induced delayed toxicity in rats.
Topics: Animals; Biotransformation; Drug Interactions; Enzyme Induction; Male; Organothiophosphates; Organothiophosphorus Compounds; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains | 1984 |
Acute target organ toxicity of 1-nitronaphthalene in the rat.
Topics: Animals; Carcinogens; Liver; Lung; Male; Naphthalenes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1984 |
Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats.
Topics: 4-Hydroxycoumarins; Animals; Dose-Response Relationship, Drug; Half-Life; Intestine, Small; Liver; Male; Phenobarbital; Proadifen; Prothrombin; Rats; Rats, Inbred Strains; Tissue Distribution; Warfarin | 1983 |
Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.
Topics: Animals; Bile; Cyclohexanes; Enzyme Induction; Glutathione; Kinetics; Male; Maleates; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Characteristics of the activation of cyclophosphamide to a mutagen by rat liver.
Topics: Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Flavonoids; In Vitro Techniques; Liver; Male; Metyrapone; Mutagens; NADP; Phenobarbital; Proadifen; Rats; Salmonella typhimurium | 1980 |
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1980 |
The effect of phenobarbital and SKF 525A on tocainide pharmacokinetics in the rat.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Drug Interactions; Male; Models, Biological; Phenobarbital; Proadifen; Rats; Tocainide | 1980 |
Effect of rifampicin on the mouse hepatic mixed-function oxidase system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rifampin; Sodium Fluoride | 1981 |
Development of tolerance to the pulmonary toxin, 4-ipomeanol.
Topics: Animals; Carbon Tetrachloride; Drug Resistance; Drug Tolerance; Enzyme Induction; Furans; Lung; Male; Mice; Naphthalenes; Phenobarbital; Proadifen; Rabbits; Rats; Terpenes; Thiourea; Time Factors; Toxins, Biological | 1981 |
Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line P815) cells.
Topics: Animals; Biotransformation; Cell Survival; Cells, Cultured; Coumarins; Cyclophosphamide; Hydrazines; Liver; Male; Mast-Cell Sarcoma; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sarcoma, Experimental | 1982 |
Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine.
Topics: Animals; Female; Lomustine; Mice; Mice, Inbred C3H; Nitrosourea Compounds; Phenobarbital; Proadifen; Sarcoma, Experimental | 1983 |
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.
Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone | 1983 |
Effect of adrenalectomy, pretreatment with SKF 525-A, phenobarbital and diethyl maleate on the acute toxicity of fenitrothion in male rats.
Topics: Adrenalectomy; Animals; Cholinesterases; Fenitrothion; Glutathione; In Vitro Techniques; Male; Maleates; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Effects of mixed-function oxidase inducers and inhibitors on cytochrome P-450 content, gel electrophoresis profiles, and 3-methylindole-induced lung toxicity in goats.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Goats; Indoles; Liver; Lung; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Proadifen; Skatole | 1983 |
Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats.
Topics: Animals; Body Weight; L-Lactate Dehydrogenase; Lethal Dose 50; Lung; Male; Organothiophosphates; Organothiophosphorus Compounds; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Inhibition of lipid peroxide decomposition by compounds which bind with cytochrome p-450.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Lipid Peroxides; Male; Microsomes, Liver; Peroxidases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1983 |
[The effect of thiamine deficiency on the actions of drugs affecting the central nervous system in rats (author's transl)].
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Brain; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Hypothalamus; Male; Neurons; Phenobarbital; Proadifen; Rats; Sleep; Tetrabenazine; Thiamine Deficiency | 1980 |
Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake--III. Induction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rana pipiens; Salmonidae; Snakes; Species Specificity; Trout | 1982 |
Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents.
Topics: Animals; Anti-Bacterial Agents; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Troleandomycin | 1982 |
Effects of inducers and inhibitors of cytochrome P-450-linked monooxygenases on the toxicity, in vitro metabolism and in vivo irreversible binding of 2-methylnaphthalene in mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Naphthalenes; Oxidoreductases; Phenobarbital; Piperonyl Butoxide; Proadifen | 1982 |
Carbon tetrachloride-mediated expiration of pentane and chloroform by the intact rat: the effects of pretreatment with diethyl maleate, SKF-525A and phenobarbital.
Topics: Animals; Carbon Tetrachloride; Chloroform; Drug Interactions; Glutathione; Lipid Peroxides; Male; Maleates; Pentanes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1982 |
Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Enzyme Induction; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1982 |
The effect of various modifiers on rat microsomal peroxidase kinetics.
Topics: Aniline Compounds; Animals; Hexobarbital; Kinetics; Lipid Peroxides; Male; Microsomes, Liver; Peroxidases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1982 |
Differential sensitivity of hepatic microsomal aryl hydrocarbon hydroxylase to the inhibitory effect of SKF 525-A in rats of varying age, hormonal- and drug-induced status.
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Disorders of Sex Development; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sex Factors | 1982 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound.
Topics: Acetaminophen; Animals; Hypothermia; Male; Mice; Phenobarbital; Piperonyl Butoxide; Proadifen; Time Factors; Tissue Distribution | 1982 |
Hepatic and renal nonprotein sulfhydryl concentration following toxic doses of hexachloro-1,3-butadiene in the rat: the effect of Aroclor 1254, phenobarbitone, or SKF 525A treatment.
Topics: Animals; Aroclors; Biotransformation; Butadienes; Kidney; Liver; Male; Phenobarbital; Proadifen; Rats; Sulfhydryl Compounds | 1981 |
Effects of inducers and/or inhibitors on metabolism of lysergic acid diethylamide in rat liver microsomes.
Topics: Animals; Biotransformation; Carbon Monoxide; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Lysergic Acid Diethylamide; Methylcholanthrene; Microsomes, Liver; NAD; Oxygen Consumption; Phenobarbital; Proadifen; Rats | 1980 |
Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Biphenyl Compounds; Chloroform; Cytochrome P-450 Enzyme System; Diethylamines; Drug Interactions; Epinephrine; Male; Phenobarbital; Proadifen; Rabbits | 1981 |
The role of cytochrome P-450 in the synthesis of polar metabolites of aldosterone by microsomes of male rat liver.
Topics: Aldosterone; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1981 |
[Activity of nonspecific hepatic oxidases and the biological effects of the antineoplastic antibiotic adriamycin].
Topics: Animals; Doxorubicin; Hexobarbital; Liver; Male; Mice; Mice, Inbred CBA; Oxidoreductases; Phenobarbital; Proadifen; Sleep | 1981 |
Metabolism of paraldehyde to acetaldehyde by rat liver microsomes.
Topics: Acetaldehyde; Animals; Biotransformation; Chromatography, Thin Layer; Kinetics; Male; Microsomes, Liver; Paraldehyde; Penicillamine; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1981 |
Effect of alterations in drug metabolism on epinephrine-induced cardiac arrhythmias in rabbits exposed to methylchloroform.
Topics: Animals; Antimetabolites; Arrhythmias, Cardiac; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Diethylamines; Epinephrine; Ethylene Chlorohydrin; Hydrocarbons, Chlorinated; Male; Phenobarbital; Proadifen; Rabbits; Trichloroacetic Acid; Trichloroethanes | 1981 |
Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethylenethiourea; Female; Imidazoles; Methylcholanthrene; Phenobarbital; Pregnancy; Proadifen; Rats; Teratogens; Time Factors | 1981 |
Effects of microsomal induction and inhibition on styrene-induced acute hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Serum Albumin; Styrenes; Sulfhydryl Compounds | 1981 |
The role of hepatic microsomal enzymes in the modulation of phencyclidine-induced toxicity.
Topics: Animals; Body Weight; Cysteine; Eating; Lethal Dose 50; Liver; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Pentobarbital; Phencyclidine; Phenobarbital; Proadifen | 1981 |
Development of a novel method for measuring covalent binding and its application to investigations of bromobenzene hepatotoxicity.
Topics: Animals; Biopolymers; Biotransformation; Bromobenzenes; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1981 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Substances of marine origin affecting pentobarbital pharmacokinetics.
Topics: Alkynes; Animals; Drug Synergism; Ethers, Cyclic; Kinetics; Male; Mice; Oxocins; Pentobarbital; Phenobarbital; Proadifen; Pyrans; Rats; Sleep | 1980 |
Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase.
Topics: Aldehyde Oxidoreductases; Aldehydes; Animals; Biotransformation; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoenzymes; Kinetics; Male; Microsomes, Liver; Mitochondria, Liver; Pargyline; Phenobarbital; Proadifen; Rats | 1980 |
Metabolism of dihalomethanes to carbon monoxide. IV. Studies in isolated rat hepatocytes.
Topics: Animals; Carbon Monoxide; Hydrocarbons, Halogenated; In Vitro Techniques; Kinetics; Liver; Male; Methane; Methylcholanthrene; Phenobarbital; Proadifen; Rats | 1980 |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Microsomes, Liver; Phenobarbital; Porphyrias; Proadifen | 1980 |
Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism.
Topics: Animals; Bone Marrow; Brain Neoplasms; Cell Division; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Gliosarcoma; Liver; Male; Phenobarbital; Proadifen; Rats; Thiotepa; Tumor Cells, Cultured | 1995 |
Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats.
Topics: Acetone; Acrylonitrile; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Digestive System; Intestinal Absorption; Lung; Male; Methacrylates; Nitriles; Phenobarbital; Proadifen; Rats; Rats, Inbred F344; Structure-Activity Relationship; Tissue Distribution | 1994 |
Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Brain; In Vitro Techniques; Male; Mice; Monoamine Oxidase Inhibitors; Phenobarbital; Piperazines; Piperonyl Butoxide; Proadifen | 1995 |
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 1994 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species.
Topics: Animals; Catalase; Cytochrome P-450 Enzyme System; Ethanol; Glutathione Peroxidase; Male; Microsomes, Liver; NADP; Pentetic Acid; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Toluene | 1994 |
Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450.
Topics: Animals; Aorta; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Microsomes; Microsomes, Liver; Nitroglycerin; Oxygen; Phenobarbital; Proadifen; Rats | 1993 |
The cytochromes P-450 are not involved in the modulation of the N-methyl-D-aspartate response by sigma ligands in the rat CA3 dorsal hippocampus.
Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electrophysiology; Guanidines; Hippocampus; Iontophoresis; Ligands; Male; N-Methylaspartate; Neurons; Paralysis; Phenobarbital; Proadifen; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma; Zoxazolamine | 1993 |
Determination of antipyrine sulphoconjugates in isolated cultured rat hepatocytes.
Topics: Animals; Antipyrine; Cells, Cultured; Chromatography; Drug Stability; Liver; Male; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Solvents; Sulfates | 1993 |
Role of cytochrome P450 in hepatotoxicity induced by di- and tributyltin compounds in mice.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Liver; Male; Mice; Mice, Inbred Strains; Organotin Compounds; Phenobarbital; Proadifen; Trialkyltin Compounds | 1995 |
Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats.
Topics: Acrylonitrile; Animals; Bile; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Male; Methacrylates; Nitriles; Phenobarbital; Proadifen; Rats; Rats, Inbred F344; Time Factors | 1996 |
Effects of feeding Artemisia filifolia and Helenium flexuosum on rabbit cytochrome P450 isozymes.
Topics: Animal Feed; Animals; Artemisia; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Plants, Medicinal; Plants, Toxic; Proadifen; Rabbits | 1996 |
Comutagenesis-III. In vitro metabolism of 2-amino-3-methylpyridine: the effect of various potential inhibitors, activators and inducers.
Topics: Amines; Aminopyridines; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Isoenzymes; Male; Microsomes, Liver; Mutagens; Oxidation-Reduction; Phenobarbital; Picolines; Polychlorinated Biphenyls; Proadifen; Rabbits | 1997 |
Pharmacokinetic changes of M1, M2, M3 and M4 after intravenous administration of a new anthracycline, DA-125, to rats pretreated with phenobarbital, 3-methylcholanthrene, chloramphenicol, or SKF-525A.
Topics: Animals; Anthracyclines; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Carcinogens; Carotid Arteries; Chloramphenicol; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Injections, Intravenous; Jugular Veins; Male; Methylcholanthrene; Phenobarbital; Proadifen; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 1998 |
Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos).
Topics: Animals; Benzimidazoles; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Ducks; Enzyme Induction; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Proadifen | 1999 |
Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Topics: Acrylonitrile; Animals; Benzimidazoles; Cyanides; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Hydrogen-Ion Concentration; Kidney; Male; Methylcholanthrene; Microsomes; NADP; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfhydryl Compounds; Temperature | 1999 |
Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Gentisates; Hydroxybenzoates; Hydroxylation; Male; Oxidative Stress; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Salicylates | 1999 |
Effects of enzyme inducers and inhibitor on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats.
Topics: Amines; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Isoniazid; Male; Phenobarbital; Proadifen; Pyrazines; Rats; Rats, Sprague-Dawley | 2000 |
Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Insecticides; Isoenzymes; Isoniazid; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2000 |
The role of enzyme induction and inhibition on cypermethrin hepatotoxicity.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Cell Survival; Cells, Cultured; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Insecticides; Male; Phenobarbital; Proadifen; Pyrethrins; Rats; Rats, Sprague-Dawley | 2001 |
Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation.
Topics: alpha-Tocopherol; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); In Vitro Techniques; Iron; Lipid Peroxidation; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Protoporphyrins; Rabbits; Steroid Hydroxylases | 2002 |
The influence of metabolism on the MAO-B inhibitory potency of selegiline.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Enzyme Induction; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenobarbital; Proadifen; Rats; Rats, Wistar; Selegiline | 2002 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Topics: Animals; Anticonvulsants; Biotransformation; Cytochrome P-450 Enzyme System; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Gas Chromatography-Mass Spectrometry; Lipid Peroxides; Liver; Male; Oxidative Stress; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Triazoles; Valproic Acid | 2003 |
STUDIES ON THE EFFECT OF CHLORCYCLIZINE AND OTHER DRUGS ON THE TOXICITY OF SEVERAL ORGANOPHOSPHATE ANTICHOLINESTERASES.
Topics: Brain; Cholinesterase Inhibitors; Cholinesterases; Cyclizine; Enzyme Inhibitors; Esterases; Histamine H1 Antagonists; Liver; Mice; Organophosphate Poisoning; Parathion; Pharmacology; Phenobarbital; Phosphorus; Piperazines; Poisons; Proadifen; Research; Toxicology | 1964 |
STUDIES OF THE INDUCTION OF MICROSOMAL S-, N- AND O-DEMETHYLASES.
Topics: Alkylation; Amino Acids; Anilides; Barbiturates; Benzopyrenes; Codeine; Enzymes; Hydantoins; Liver; Meperidine; Microsomes; Morphine; Oxidoreductases, O-Demethylating; Pharmacology; Phenobarbital; Proadifen; Purines; Rats; Research | 1964 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmacology; Phenobarbital; Proadifen; Rats; Research; Sex; Steroid Hydroxylases; Testosterone | 1964 |
ENHANCED SULFOBROMOPHTHALEIN DISAPPEARANCE IN MICE PRETREATED WITH VARIOUS DRUGS.
Topics: Countercurrent Distribution; Ethionine; Liver; Metabolism; Mice; Nikethamide; Pharmacology; Phenobarbital; Proadifen; Research; Sulfobromophthalein; Tolbutamide; Urethane | 1965 |
Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.
Topics: Animals; Bleeding Time; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Male; Medroxyprogesterone Acetate; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Wistar; Recombinant Proteins; Thrombophilia | 2003 |
Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile.
Topics: Acrylonitrile; Animals; Anticonvulsants; Carcinogens; Central Nervous System Depressants; Cyanides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Ethanol; Imidazoles; Male; Phenobarbital; Phenytoin; Proadifen; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2005 |
Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats.
Topics: Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Hypnotics and Sedatives; Isoenzymes; Itraconazole; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 2006 |
Role of metabolism in 1-bromopropane-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hydrocarbons, Brominated; Liver; Male; Mice; Mice, Inbred ICR; Phenobarbital; Proadifen; Specific Pathogen-Free Organisms; Spectrometry, Mass, Electrospray Ionization; Thiobarbituric Acid Reactive Substances | 2010 |