proadifen has been researched along with nadp in 130 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 112 (86.15) | 18.7374 |
| 1990's | 13 (10.00) | 18.2507 |
| 2000's | 4 (3.08) | 29.6817 |
| 2010's | 1 (0.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Docks, EL; Krishna, G | 1 |
| Grundlin, R; Moldéus, P; Orrenius, S; Vadi, H | 1 |
| Evans, IH; McIntosh, PR; Rabin, BR | 1 |
| Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M | 1 |
| Gilev, AP; Khagi, KhB; Meĭren, DV; Sniedze, TN; Urbanovich, EL | 1 |
| Jonsson, J | 1 |
| Gillette, JR; Krishna, G; Sipes, IG | 1 |
| Castro, JA; Diaz Gomez, MI; Godoy, HM | 1 |
| Dvorchik, BH; Hartman, RD; Marietta, MP; Vesell, ES; Weisz, J | 1 |
| Ivanetich, KM; Lucas, SA; Marsh, JA | 1 |
| Artigou, JY; Benhamou, JP; Descatoire, V; Pessayre, D; Wandscheer, JC | 1 |
| Freeman, RW; Harbison, RD; Oates, JA; Woosley, RL | 1 |
| Kraus, P | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Kawalek, JC; Lu, AY | 1 |
| Beckett, AH; Dajani, RM; Gorrod, JW | 1 |
| Dalezios, JI; Hsieh, DP; Krieger, RI; Salhab, AS | 1 |
| Dalvi, RR; HUNTER, AL; Neal, RA | 1 |
| Roach, MK | 1 |
| Grudin, R; Moldèus, P; Orrenius, S; Vadi, H | 1 |
| Kappus, H; Remmer, H | 1 |
| Abreu-Greenberg, M; Busbee, DL; Cantrell, ET; Guyden, J | 1 |
| Bridges, JW; Elcombe, CR; Illing, HP; King, LJ; Netter, KJ; Nimmo-Smith, RH; Wolf, CR | 1 |
| Beckett, AH; Gorrod, JW; Temple, DJ | 1 |
| Daniels, JM; Massey, TE | 1 |
| Araki, J; Masubuchi, Y; Narimatsu, S; Suzuki, T | 1 |
| Ruse, MJ; Waring, RH | 1 |
| Chen, NQ; Holtzman, JL; Srivastava, SP | 1 |
| Cavazos, R; Diaz, RG; Farooqui, MY | 1 |
| Hamid, AB; Smith, JE | 1 |
| Hanzlik, RP; Traiger, GJ; Vyas, KP | 1 |
| Crowley, CA; Jellinck, PH; Quail, JA | 1 |
| Haim, N; Nemec, J; Roman, J; Sinha, BK | 1 |
| Kammerer, RC; Lampe, MA | 1 |
| Mulder, GJ; Nagelkerke, JF; Paul, LC; Schwarz, EP; Tijdens, RB; Winters, MF | 1 |
| Athar, M; Bickers, DR; Mukhtar, H | 1 |
| Forkert, PG; Hofley, M; Racz, WJ | 1 |
| Smith, AG; Stewart, FP | 1 |
| Gram, TE; Okine, LK | 1 |
| Nakamura, K; Nishigaki, T; Tanaka, M | 1 |
| Coon, MJ; Holm, KA; Koop, DR; Kupfer, D; Theoharides, AD | 1 |
| Berlin, T; Larsson, R; Moldéus, P; Olsson, LI; Ross, D | 1 |
| Abraham, NG; Dunn, MW; Masferrer, J; McGiff, JC; Schwartzman, ML | 1 |
| Kuwahara, S; Mannering, GJ | 1 |
| Braun, AG; Harding, FA; Weinreb, SL | 1 |
| Wickramasinghe, SN | 1 |
| Inoue, T; Kishi, T; Niwaguchi, T; Suzuki, S; Yasuda, T | 1 |
| de Ruiter, C; de Vries, J; Gobas, F; Kootstra, PR; Pinedo, HM; van Maanen, JM | 1 |
| Koransky, W; Vohland, HW | 1 |
| Gurtoo, HL | 1 |
| Dave, C; Gurtoo, HL | 1 |
| Van Dyke, RA; Wood, CL | 1 |
| Bickel, MH; Willi, P | 1 |
| Correia, MA; Mannering, GJ | 1 |
| Chang, RL; Lin, CC; Symchowicz, S | 1 |
| Dewitt-Harley, S; Goldstein, L | 1 |
| Ahmad, S; Knowles, CO | 1 |
| Bolt, HM; Kappus, H; Remmer, H | 2 |
| Coscia, CJ; Meehan, TD | 1 |
| Hellmer, KH; Tabarelli-Poplawski, S; Uehleke, H | 1 |
| Jose, PJ; Slater, TF | 1 |
| Rane, A | 1 |
| Kampffmeyer, HG | 1 |
| Inoue, T; Nakahara, Y; Niwaguchi, T | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| Illing, HP; Kunke, S; Netter, KJ | 1 |
| Gupta, RP; Raj, HG; Santhanam, K; Venkitasubramanian, TA | 1 |
| Douch, PG | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Boulton, CA; Crabbe, MJ; Large, PJ | 1 |
| Conney, AH; Kuntzman, R; Welch, R | 1 |
| Creaven, PJ; Parke, DV; Williams, RT | 1 |
| Leibman, KC | 1 |
| Kerza-Kwiatecki, A; Mazel, P; Simanis, J | 1 |
| Kupfer, D; Peets, L | 1 |
| Dennis, DT; West, CA | 1 |
| Roberts, JB; Thomas, BH; Wilson, A | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 2 |
| Gerhards, E | 1 |
| Akov, S; Borkovec, AB; Oliver, JE | 1 |
| Mitoma, C; Tagg, J | 1 |
| Jones, TM; Kupfer, D; Partridge, R | 1 |
| Gillette, JR; Sasame, HA | 1 |
| Ichiha, K; Kushunose, E; Kusunose, M | 1 |
| Ichihara, K; Kusunose, E; Kusunose, M | 1 |
| Creaven, PJ; Reese, WN; Roach, MK | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 1 |
| Carlson, GP; DuBois, KP | 1 |
| Folsom, MD; Hodgson, E | 2 |
| Kutt, H; Verebely, K | 1 |
| Rabin, BR; Williams, DJ | 1 |
| Schechter, MS; Williamson, RL | 1 |
| Ackermann, E | 1 |
| Kalant, H; Khanna, JM; Lin, G | 1 |
| Sawyer, BC; Slater, TF | 1 |
| Garner, JV; Garner, RC; Hanson, RS; Miller, EC; Miller, JA | 1 |
| Breyer, U | 1 |
| Feuer, G | 1 |
| Mattocks, AR; White, IN | 1 |
| Bickel, MH | 1 |
| Mazel, P; Shargel, L | 1 |
| Douch, PG; Smith, JN; Turner, JC | 1 |
| Chopra, P; Nayak, NC; Ramalingaswami, V; Roy, S | 1 |
| Kupfer, D; Levin, E | 1 |
| Bend, JR; Easterling, RE; Fouts, JR; Gram, TE; Hook, GE | 1 |
| Allen, LM; Creaven, PJ | 1 |
| Devereux, TR; Fouts, JR | 1 |
| Catalani, P; Donelli, MG; Garattini, E; Pantarotto, C | 1 |
| Clement, B | 1 |
| Eboli, ML; Galeotti, T; Kapoor, SC; Palombini, G; van Rossum, GD | 1 |
| Hales, BF; Jain, R | 1 |
| Ruenitz, PC; Toledo, MM | 1 |
| Hollenberg, PF; Koop, DR | 1 |
| Awazu, S; Horie, T; Yokoyama, H | 1 |
| Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW | 1 |
| Lennard, MS; Martin, IJ; Tucker, GT; Williams, ML | 1 |
| Bend, JR; Knickle, LC | 1 |
| Bondy, SC; Naderi, S | 1 |
| Waxman, DJ; Weber, GF | 1 |
| Kurosawa, T; Liehr, JG; Sarabia, SF; Tohma, M; Zhu, BT | 1 |
| Abdel-Aziz, AH; Abdel-Naim, AB; Abo-Salem, O; Hamada, FM; Mostafa, AM | 1 |
| Doi, H; Horie, T; Iwasaki, H; Masubuchi, Y; Nishigaki, R | 1 |
| Igarashi, K; Kasuya, F; Katagi, M; Nishikawa, M; Tsuchihashi, H; Tsutsumi, H | 1 |
| Ishihara, Y; Shiba, D; Shimamoto, N | 1 |
| Franklin, MR; Hathaway, LB | 1 |
| Aracena, P; Letelier, ME; López-Valladares, M; Peredo-Silva, L; Rojas-Sepúlveda, D | 1 |
1 review(s) available for proadifen and nadp
| Article | Year |
|---|---|
Factors influencing steroid hydroxylases in liver microsomes.
Topics: Age Factors; Animals; Carbon Isotopes; Chlordan; DDT; Dogs; Estradiol; Guinea Pigs; Hexobarbital; In Vitro Techniques; Insecticides; Liver; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen Consumption; Phenobarbital; Phenylbutazone; Phosphates; Polycyclic Compounds; Proadifen; Progesterone; Rabbits; Rats; Sex Factors; Steroids; Testosterone | 1966 |
129 other study(ies) available for proadifen and nadp
| Article | Year |
|---|---|
Covalent binding of trans-stilbene to rat liver microsomes.
Topics: Animals; Glutathione; In Vitro Techniques; Kidney; Liver; Male; Microsomes, Liver; NADP; Proadifen; Protein Binding; Rats; Stilbenes; Time Factors | 1975 |
Proceedings: Isolated liver cells: a valuable tool for the study of drug metabolism.
Topics: Alprenolol; Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Kinetics; Liver; Metyrapone; NADP; Proadifen; Rats | 1975 |
The effect of aflatoxins on the incorporation of RNA and protein precursors by isolated hepatocytes.
Topics: Aflatoxins; Amino Acids; Animals; Antimetabolites; Cell Survival; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; NADP; Orotic Acid; Proadifen; Protein Biosynthesis; Protein Precursors; Rats; RNA | 1976 |
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes | 1976 |
[Participation of non-specific rat liver microsome oxidases in destruction of Nl-furanidylpyrimidines].
Topics: Animals; Biotransformation; Fluorouracil; Male; Microsomes, Liver; NADP; Proadifen; Rats; Tegafur | 1977 |
On the aromatic hydroxylation of amphetamine in rat liver microsomes and perfused liver preparations: effects of long-term administration.
Topics: Administration, Oral; Amphetamines; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Desipramine; Fenfluramine; Hydroxylation; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Perfusion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450.
Topics: Allylisopropylacetamide; Animals; Bromotrichloromethane; Carbon Monoxide; Carbon Tetrachloride; Chloroform; Cytochrome P-450 Enzyme System; Glutathione; Immune Sera; In Vitro Techniques; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Nitrogen; Proadifen; Protein Binding; Rats | 1977 |
Mechanism of dimethylnitrosamine metabolism and activation in rats.
Topics: Animals; Biotransformation; Carbon Dioxide; Cobalt; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrosamines; Nucleic Acids; Phenobarbital; Proadifen; Protein Binding; Rats; Subcellular Fractions | 1978 |
Characterization of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain: comparison with hepatic aminopyrine N-demethylation.
Topics: Aminopyrine N-Demethylase; Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Brain; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Kinetics; Male; Meperidine; Microsomes; Microsomes, Liver; NAD; NADP; Proadifen; Proteins; Rats | 1979 |
Enflurane and methoxyflurane. Their interaction with hepatic cytochrome P-450 in vitro.
Topics: Animals; Cytochrome P-450 Enzyme System; Enflurane; Fluorides; In Vitro Techniques; Kinetics; Liver; Male; Methoxyflurane; Methyl Ethers; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Rats | 1979 |
Formation and inactivation of a chemically reactive metabolite of vinyl chloride.
Topics: Animals; Cysteine; Cytochrome P-450 Enzyme System; DDT; Epoxide Hydrolases; Epoxy Compounds; Glutathione; Hydrocarbons, Chlorinated; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Protein Binding; Rats; Vinyl Chloride; Vinyl Compounds | 1979 |
Evidence for the biotransformation of procainamide to a reactive metabolite.
Topics: Acetylation; Animals; Biotransformation; Hydralazine; Male; Mice; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Procainamide; Salmonella typhimurium | 1979 |
Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver.
Topics: Acetone; Animals; Biodegradation, Environmental; Carbon Monoxide; Cytosol; Female; Glutathione; Hexachlorocyclohexane; Liver; Microsomes, Liver; NADP; Proadifen; Rats; Sulfobromophthalein | 1975 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome Reductases; Cytochromes; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Pharmaceutical Preparations; Proadifen; Rabbits; Rats | 1975 |
In vitro hepatic and extra-hepatic reduction of (minus)-nicotine-1'-N-oxide in rats.
Topics: Anaerobiosis; Animals; Carbon Monoxide; Chromatography, Gas; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Digestive System; Duodenum; Edetic Acid; Flavins; Gastric Mucosa; Ileum; In Vitro Techniques; Intestines; Kidney; Kinetics; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mitochondria, Liver; Myocardium; NADH, NADPH Oxidoreductases; NADP; Nicotine; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Proadifen; Proteins; Rats | 1975 |
Aflaxation B1 hydroxylation by hepatic microsomal preparations from the rhesus monkey.
Topics: Aflatoxins; Animals; Biotransformation; Carbon Monoxide; Hydrogen-Ion Concentration; Hydroxylation; In Vitro Techniques; Macaca mulatta; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Proadifen; Time Factors | 1975 |
Toxicological implications of the mixed-function oxidase catalyzed metabolism of carbon disulfide.
Topics: Animals; Benzphetamine; Carbon Disulfide; Cytochrome P-450 Enzyme System; Heme; Kinetics; Male; Malondialdehyde; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Proadifen; Protein Binding; Rats; Sulfur Oxides; Sulfur Radioisotopes | 1975 |
Microsomal ethanol oxidation: activity in vitro and in vivo.
Topics: Animals; Azides; Carbon Monoxide; Catalase; Cyanides; Ethanol; Hydrogen Peroxide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Pyrazoles; Rats | 1975 |
Drug metabolism in isolated rat liver cells.
Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium | 1975 |
Irreversible protein binding of [14-C]imipramine with rat and human liver microsomes.
Topics: Animals; Carbon Monoxide; Cattle; Cytochrome P-450 Enzyme Inhibitors; Epoxide Hydrolases; Humans; Imipramine; In Vitro Techniques; Male; Microsomes, Liver; NADP; Proadifen; Protein Binding; Rats; Rifampin; Serum Albumin, Bovine; Sulfhydryl Compounds; Time Factors | 1975 |
Metabolism of diphenyloxazole (PPO) by mouse liver microsomes.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carbon Monoxide; Depression, Chemical; Enzyme Induction; Flavonoids; Kinetics; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxazoles; Proadifen | 1975 |
Measurement of substrate-induced oxygen uptake during microsomal drug oxidation using a gold micro-electrode.
Topics: Animals; Biphenyl Compounds; Cell-Free System; Gold; Hexobarbital; Kinetics; Male; Microelectrodes; Microsomes, Liver; Morphine; Morphine Derivatives; NADP; Naphthalenes; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Polarography; Proadifen; Rats | 1975 |
The differentiation of N-oxidation and N-dealkylation of N-ethyl-N-methylaniline by rabbit liver microsomes as distinct metabolic routes.
Topics: 2,2'-Dipyridyl; Acetone; Aniline Compounds; Animals; Chloromercuribenzoates; Cysteamine; Cytochrome P-450 Enzyme System; Dealkylation; Dithiothreitol; Ethylmaleimide; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Proadifen; Rats; Subcellular Fractions | 1975 |
Modulation of aflatoxin B1 biotransformation in rabbit pulmonary and hepatic microsomes.
Topics: Aflatoxin B1; Aflatoxin M1; Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Isoenzymes; Kinetics; Lung; Male; Microsomes; Microsomes, Liver; NADP; Oxidoreductases; Proadifen; Rabbits | 1992 |
Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein.
Topics: Animals; Biotransformation; Carbon Monoxide; Cysteine; Cytochrome P-450 Enzyme System; Debrisoquin; Dose-Response Relationship, Drug; Female; Glutathione; Lidocaine; Male; Microsomes, Liver; NADP; Oxygen; Proadifen; Propranolol; Proteins; Quinidine; Rats; Rats, Inbred Strains | 1992 |
The S-oxidation of thioamides by rat liver microsomes.
Topics: Amines; Animals; Ethionamide; Kinetics; Male; Methimazole; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains | 1991 |
The effect of substrates and inhibitors of cytochrome P-450 on the NADPH inhibition of the ATP-dependent, hepatic, microsomal calcium pump.
Topics: Aminopyrine; Animals; Benzphetamine; Calcium; Calcium-Transporting ATPases; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Male; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains | 1990 |
Metabolism of methacrylonitrile to cyanide: in vitro studies.
Topics: Animals; Biotransformation; Cyanides; Cytochrome P-450 Enzyme System; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methacrylates; Microsomes, Liver; NADP; Nitriles; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
Degradation of aflatoxin by Aspergillus flavus.
Topics: Aflatoxin B1; Aflatoxins; Aspergillus flavus; Cycloheximide; Cytochrome c Group; Metyrapone; NADP; Periodic Acid; Potassium Cyanide; Proadifen | 1987 |
Effect of inhibitors of alpha-naphthylisothiocyanate-induced hepatotoxicity on the in vitro metabolism of alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Aminopyrine; Animals; Bilirubin; Biotransformation; Chromatography, Gas; Ditiocarb; Ethionamide; Hyperbilirubinemia; Imidazoles; Kinetics; Male; Methimazole; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Thiocyanates | 1985 |
Normal and recombinant human growth hormone administered by constant infusion feminize catechol estrogen formation by rat liver microsomes.
Topics: Animals; Estradiol; Estrogens, Catechol; Female; Growth Hormone; Humans; Male; Microsomes, Liver; NADP; Proadifen; Rats; Rats, Inbred Strains; Recombinant Proteins | 1985 |
In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Etoposide; Mice; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Proadifen; Proteins | 1987 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450.
Topics: Animals; Cells, Cultured; Cyclosporins; Cytochrome P-450 Enzyme System; Kinetics; Macromolecular Substances; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1987 |
Cytochrome P-450 dependent metabolism of testosterone in rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Metyrapone; Microsomes; NADP; Pregnancy; Proadifen; Rats; Rats, Inbred Strains; Skin; Steroid Hydroxylases; Testosterone | 1987 |
Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes.
Topics: Animals; Biotransformation; Carbon Monoxide; Dichloroethylenes; Hydrocarbons, Chlorinated; Lung; Male; Mice; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Piperonyl Butoxide; Proadifen | 1987 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
In vitro metabolism of ACNU, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitroso urea hydrochloride, a water-soluble antitumor nitrosourea.
Topics: Animals; Antineoplastic Agents; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Microsomes, Liver; NADP; Nimustine; Nitrosourea Compounds; Phenobarbital; Proadifen; Rats; Temperature; Time Factors | 1985 |
omega-1 and omega-2 hydroxylation of prostaglandins by rabbit hepatic microsomal cytochrome P-450 isozyme 6.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dinoprostone; Ethanol; Hydroxylation; Imidazoles; Isoenzymes; Kinetics; Miconazole; Microsomes, Liver; NADP; Proadifen; Prostaglandins; Prostaglandins E; Rabbits; Safrole | 1985 |
Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney.
Topics: Acetaminophen; Aminophenols; Animals; Arachidonic Acid; Arachidonic Acids; Glutathione; Glutathione Disulfide; Humans; Indomethacin; Kidney; Kinetics; Linolenic Acids; Lipid Peroxides; Male; Metyrapone; Microsomes; Models, Chemical; NADP; Phenetidine; Proadifen; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rabbits | 1985 |
Cytochrome P450 dependent metabolism of arachidonic acid in bovine corneal epithelium.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cattle; Chromatography, Thin Layer; Cornea; Cytochrome P-450 Enzyme System; Epithelium; Microsomes; NADP; Proadifen | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
Teratogen metabolism: thalidomide activation is mediated by cytochrome P-450.
Topics: Amines; Animals; Biotransformation; Carbon Monoxide; Catalase; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Isoenzymes; Microsomes, Liver; NADP; Proadifen; Spectrophotometry; Superoxide Dismutase; Thalidomide | 1986 |
Observations on the biochemical basis of ethanol metabolism by human macrophages.
Topics: Amitrole; Carbon Monoxide; Catalase; Cell Survival; Cells, Cultured; Ethanol; Humans; Macrophages; Metyrapone; NADP; Proadifen; Pyrazoles | 1986 |
The metabolism of 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in the rat in vivo and in vitro.
Topics: Animals; Appetite Depressants; Biotransformation; Carbon Monoxide; Chromatography, Gas; Chromatography, Thin Layer; Furans; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins.
Topics: Animals; Ascorbic Acid; Biotransformation; Cytochrome P-450 Enzyme System; Etoposide; HeLa Cells; Humans; In Vitro Techniques; Microsomes; Microsomes, Liver; NADP; Neoplasm Proteins; Nitrogen Oxides; Phenobarbital; Podophyllotoxin; Proadifen; Protein Binding; Pyridines; Rats; Rats, Inbred Strains | 1985 |
Effect of -hexachlorocyclohexane on metabolism and excretion of pentetrazol (cardiazol) in the rat.
Topics: Animals; Anticonvulsants; Brain; Carbon Monoxide; Female; Half-Life; Haplorhini; Hexachlorocyclohexane; Microsomes, Liver; NADP; Oxidoreductases; Oxygen; Pentylenetetrazole; Proadifen | 1972 |
On the binding of aflatoxin B 1 and its metabolites to hepatic microsomes.
Topics: Aflatoxins; Animals; Carbon Isotopes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; In Vitro Techniques; Isocitrate Dehydrogenase; Isocitrates; Male; Microsomes, Liver; NADP; Oxidoreductases; Proadifen; Proteins; Rats; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Interaction of aflatoxin B 1 metabolite with rat liver RNA.
Topics: Aflatoxins; Animals; Biotransformation; Chromatography, Gel; Edetic Acid; Male; Microsomes, Liver; NADP; Oxidoreductases; Proadifen; Rats; RNA; Spectrum Analysis; Tritium | 1973 |
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats | 1973 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.
Topics: Acetates; Aniline Compounds; Animals; Calcium; Depression, Chemical; Edetic Acid; Formaldehyde; Glycols; Kinetics; Magnesium; Male; Methylation; Microsomes, Liver; NADP; Niacinamide; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Species Specificity; Stimulation, Chemical; Sulfhydryl Reagents; Swine | 1973 |
Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Codeine; Cyanides; Cytochrome P-450 Enzyme System; Drug Synergism; Female; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; NAD; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Phospholipases; Proadifen; Protein Binding; Rats | 1973 |
Oxidative demethylation of 14C-griseofulvin by liver microsomes of rats and mice.
Topics: Animals; Carbon Isotopes; Dealkylation; Griseofulvin; In Vitro Techniques; Kinetics; Male; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Proteins; Rats; Species Specificity | 1973 |
Trimethylamine oxidase of nurse shark liver and its relation to mammalian mixed function amine oxidase.
Topics: Aniline Compounds; Animals; Azides; Carbon Isotopes; Chlorpromazine; Hydrogen-Ion Concentration; Kinetics; Liver; Methylamines; Microsomes, Liver; Monoamine Oxidase; NAD; NADP; Oxidoreductases; Proadifen; Sharks; Species Specificity; Spectrophotometry; Subcellular Fractions | 1973 |
Metabolism of N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlorphenamidine) and 4'-chloro-o-formotoluidide by rat hepatic microsomal and soluble enzymes.
Topics: Amidines; Animals; Autoradiography; Carbon Isotopes; Chlorine; Formaldehyde; Hydrogen-Ion Concentration; In Vitro Techniques; Insecticides; Isoflurophate; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Proadifen; Rats; Time Factors; Toluene; Toluidines | 1971 |
Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Charcoal; Chromatography, Gel; Chromatography, Ion Exchange; Endoplasmic Reticulum; Estradiol; Ethinyl Estradiol; Female; Hydroxylation; Male; Microsomes, Liver; NADP; Peptide Fragments; Phenobarbital; Proadifen; Protein Binding; Proteins; Rats; Serum Albumin, Bovine; Time Factors; Tritium; Trypsin | 1973 |
Hydroxylation of geraniol and nerol by a monooxygenase from Vinca rosea.
Topics: Alcohols; Azides; Carbon Monoxide; Chromatography, Thin Layer; Cyanides; Hydroxylation; Microsomes; NADP; Oxidoreductases; Plant Cells; Plants; Proadifen; Terpenes; Tritium | 1973 |
Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.
Topics: Anaerobiosis; Animals; Carbon Monoxide; Carbon Radioisotopes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Glutathione; Halothane; In Vitro Techniques; Kidney; Lung; Metyrapone; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Proadifen; Protein Binding; Rabbits; Spectrophotometry; Sulfites | 1973 |
The stimulation of lipid peroxidation produced by dimethylnitrosamine in rat liver microsomes in vitro: the effects of promethazine and inhibitors of drug metabolism, and a comparison with previous studies using carbon tetrachloride.
Topics: Animals; Binding Sites; Carbon Tetrachloride; Chloromercuribenzoates; Cytochrome P-450 Enzyme System; Female; Kinetics; Lipid Metabolism; Male; Microsomes, Liver; NAD; NADP; Nitrosamines; Proadifen; Promethazine; Protein Binding; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors | 1973 |
N-oxidation of a tertiary amine (N,N-dimethylaniline) by human fetal liver microsomes.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Chromatography, Paper; Dimethylamines; Female; Fetus; Gestational Age; Humans; Kinetics; Liver; Male; Microsomes, Liver; Middle Aged; NADP; Nitrogen Oxides; Oxidation-Reduction; Proadifen; Rats | 1974 |
Studies on the metabolism of ethynylestradiol in vitro and in vivo: the significance of 2-hydroxylation and the formation of polar products.
Topics: Animals; Carbon Monoxide; Chromatography; Chromatography, Thin Layer; Estradiol; Estrone; Ethinyl Estradiol; Glutathione; Hydroxylation; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A.
Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dealkylation; Dialysis; Dogs; Half-Life; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenacetin; Phenazines; Phenobarbital; Proadifen; Proteins | 1974 |
Studies on enzymatic dealkylation of D-lysergic acid diethylamide (LSD).
Topics: Acetylcholine; Animals; Chlorpromazine; Chromatography, Thin Layer; Dealkylation; Depression, Chemical; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Lysergic Acid Diethylamide; Male; Meprobamate; Microsomes, Liver; NAD; NADP; Nitrazepam; Norepinephrine; Proadifen; Rabbits; Rats; Serotonin; Species Specificity; Subcellular Fractions; Time Factors | 1974 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
On the spectral intermediate at 440 nm formed during mixed function substrate oxidation.
Topics: Acetanilides; Aniline Compounds; Animals; Barbiturates; Cytochrome P-450 Enzyme System; Desipramine; Imipramine; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pentobarbital; Proadifen; Protein Binding; Rats; Spectrophotometry, Ultraviolet | 1974 |
Oxidative metabolism of aflatoxin B1 by rat liver microsomes in vitro and its effect on lipid peroxidation.
Topics: Adenosine Diphosphate; Aflatoxins; Animals; Ascorbic Acid; Aspergillus flavus; Chromatography, Thin Layer; Edetic Acid; In Vitro Techniques; Lipid Metabolism; Lipids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Peroxides; Phenobarbital; Proadifen; Rats; Spectrophotometry, Ultraviolet | 1974 |
The metabolism of some thioureidobenzene fungicides in mice and sheep.
Topics: Animals; Benzene Derivatives; Benzimidazoles; Brain; Carbamates; Carbon Monoxide; Chromatography; Chromatography, Thin Layer; Crystallization; Feces; Fungicides, Industrial; Glucuronates; Glucuronidase; Intestinal Mucosa; Kidney; Liver; Male; Mice; NADP; Organ Specificity; Oxidation-Reduction; Phenylthiourea; Proadifen; Sheep; Silicon Dioxide; Species Specificity; Structure-Activity Relationship; Sulfatases; Sulfuric Acids; Thiourea | 1974 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
Microbial oxidation of amines. Partial purification of a trimethylamine mono-oxygenase from Pseudomonas aminovorans and its role in growth on trimethylamine.
Topics: Amines; Carbon Monoxide; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cyanides; Hydrogen-Ion Concentration; Methylamines; NADP; Onium Compounds; Oxygenases; Potassium; Proadifen; Pseudomonas; Quaternary Ammonium Compounds; Spectrophotometry; Sulfides; Sulfonium Compounds; Ultrasonics | 1974 |
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes.
Topics: Animals; Anura; Birds; Carnivora; Cats; Chloromercuribenzoates; Coumarins; Fluorescence; Fluorometry; Guinea Pigs; In Vitro Techniques; Insecta; Liver; Mice; Microsomes; Mixed Function Oxygenases; NAD; NADP; Physiology, Comparative; Poultry; Proadifen; Rabbits; Rats; Subcellular Fractions | 1965 |
Metabolism of trichloroethylene in liver microsomes. I. Characteristics of the reaction.
Topics: Animals; Chloral Hydrate; Chloromercuribenzoates; Cyanides; Dogs; Enzymes; Ethylmaleimide; Flavin Mononucleotide; Freeze Drying; In Vitro Techniques; Iodoacetates; Ions; Liver; Methylene Blue; Microsomes; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Trichloroethylene; Vitamin K | 1965 |
Studies on the demethylation of puromycin and related compounds by liver microsomal enzymes.
Topics: Animals; In Vitro Techniques; Liver; Microsomes; NADP; Nucleosides; Phenobarbital; Proadifen; Purines; Puromycin; Rats | 1966 |
The effect of o,p'DDD on cortisol and hexobarbital metabolism.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Chromatography; Dichlorodiphenyldichloroethane; Hexobarbital; Hydrocortisone; Liver; Male; Microsomes; NADP; Proadifen; Rats | 1966 |
Biosynthesis of gibberellins. 3. The conversion of (-)-kaurene to (-)-kauren-19-oic acid in endosperm of Echinocystis macrocarpa Greene.
Topics: Carbon Isotopes; Centrifugation; Chloromercuribenzoates; Chromatography; Enzymes; Gibberellins; Mevalonic Acid; Microsomes; NAD; NADP; Oxidoreductases; Plants; Proadifen; Terpenes | 1967 |
Metabolism of neostigmine in vitro.
Topics: Animals; Carbon Isotopes; In Vitro Techniques; Liver; Male; Microsomes; NADP; Neostigmine; Proadifen; Quaternary Ammonium Compounds; Rats | 1968 |
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; Kinetics; Liver; Male; Microsomes; Morphine; NADP; Niacinamide; Oxidation-Reduction; Pigments, Biological; Proadifen; Rats; Sex Factors; Spectrophotometry; Transferases | 1968 |
[On 2-benzolsulfonylamino-5 (beta-methoxyethoxy) pyrimidine (Glycodiazin). VII. On the mechanism of demethylation of Glycodiazin].
Topics: Animals; Buffers; Carbon Monoxide; Cyanides; Cytoplasm; Edetic Acid; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kidney; Liver; Male; Metals; Microsomes; NADP; Oxygen; Phenanthrolines; Potassium; Proadifen; Rats; Sulfonamides | 1968 |
N-demethylation of the chemosterilant HEMPA by ouse fly microscomes.
Topics: Animals; Carbon Monoxide; Chemosterilants; Houseflies; In Vitro Techniques; Insect Control; Microsomes; NADP; Oxygen; Phosphoric Acids; Proadifen; Rats; Serum Albumin, Bovine | 1968 |
Studies on the microsomal drug-metabolizing enzyme system--effect of isooctane and pyridine nucleotides.
Topics: Acetanilides; Adenosine Triphosphate; Aminopyrine; Aniline Compounds; Animals; Guanine Nucleotides; Hydrocarbons; Kinetics; Lipids; Liver; Male; Microsomes; NADP; Nitrophenols; Nucleotides; Proadifen; Proteins; Pyridines; Rabbits; Rats; RNA | 1968 |
Alteration in the magnitude of induction of tyrosine transaminase by glucocorticoids. II. Effects of phenobarbital, o,p' DDD and diethylaminoethyl diphenylpropylacetate (SKF 525A) on metabolism of triamcinolone acetonide.
Topics: Adrenal Glands; Adrenalectomy; Animals; Chromatography, Thin Layer; Depression, Chemical; Dichlorodiphenyldichloroethane; Drug Synergism; Enzyme Induction; Kinetics; Liver; Male; NADP; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Time Factors; Triamcinolone Acetonide; Tritium; Tyrosine Transaminase | 1969 |
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Sex Factors; Spectrophotometry; Time Factors; Valerates | 1969 |
Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzoates; Carbon Monoxide; Cytochromes; Ethylamines; Hexobarbital; Imidazoles; In Vitro Techniques; Kinetics; Liver; Male; Mice; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Proadifen; Pyridines; Spectrophotometry | 1969 |
Some properties and distribution of the omega-hydroxylation system of medium-chain fatty acids.
Topics: Animals; Anura; Carbon Isotopes; Carbon Monoxide; Cattle; Chromatography, Gas; Chromatography, Thin Layer; Columbidae; Cyanides; Cyprinidae; Cytochromes; Dogs; Fatty Acids; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Lung; Male; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Proadifen; Rabbits; Rats; Salts; Species Specificity; Swine | 1969 |
Microsomal hydroxylation of decane.
Topics: Alcohols; Alkanes; Aniline Compounds; Animals; Carbon Isotopes; Carbon Monoxide; Cattle; Chick Embryo; Columbidae; Cyanides; Fatty Acids; Glycols; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Lung; Male; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Phenobarbital; Proadifen; Rabbits; Rats | 1969 |
Ethanol oxidation in the microsomal fraction of rat liver.
Topics: Acetaldehyde; Animals; Azides; Biphenyl Compounds; Carbon Monoxide; Catalase; Cattle; Cyanides; Cytochromes; Depression, Chemical; Ethanol; Glucose; Glucose Oxidase; Liver; Male; Microsomes; NADP; Peroxides; Proadifen; Rats; Stimulation, Chemical; Triazoles | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Studies on the induction of nitroreductase activity by DDT and phenobarbital.
Topics: Aminobenzoates; Animals; Benzoates; Cyanides; DDT; Enzyme Induction; Liver; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats; Sodium; Venoms | 1970 |
Biochemical characteristics of insect microsomes: NADPH oxidation by intact microsomes from the housefly, Musca domestica.
Topics: Animals; Carbon Monoxide; Chloromercuribenzoates; Copper; Cyanides; Cytochromes; Depression, Chemical; Ethylmaleimide; Female; Houseflies; Iodoacetates; Kinetics; Male; Microsomes; NAD; NADP; Oxidoreductases; Proadifen; Pyridines; Pyrroles; Stimulation, Chemical; Sulfhydryl Compounds; Zinc | 1970 |
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.
Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature | 1970 |
Distruption by carcinogens of the hormone dependent association of membranes with polysomes.
Topics: Animals; Carcinogens; Endoplasmic Reticulum; Enzyme Activation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; p-Dimethylaminoazobenzene; Proadifen; Rats; Ribosomes; RNA; Sulfides | 1971 |
Microsomal epoxidation of aldrin in lepidopterous larvae.
Topics: Aerobiosis; Animals; Ascorbic Acid; Carbon Monoxide; Cattle; Chromatography, Gas; Cyanides; Cytochromes; Dieldrin; Edetic Acid; Ethers, Cyclic; Hydrocarbons, Halogenated; Insecta; Insecticides; Kinetics; Larva; Microsomes; NADP; Naphthalenes; Niacinamide; Oxidation-Reduction; Potassium; Proadifen; Serum Albumin, Bovine; Species Specificity; Spectrophotometry; Ultracentrifugation; Urea; Valerates | 1970 |
[Demethylation of aminophenazone and codeine in human liver. An investigation of microsomal electron transport].
Topics: Aminopyrine; Animals; Codeine; Cyanides; Cytochromes; Dealkylation; Electron Spin Resonance Spectroscopy; Electron Transport; Female; Glucosephosphate Dehydrogenase; Half-Life; Humans; Kinetics; Lysosomes; Male; Mathematics; Methylation; Microsomes, Liver; Middle Aged; Mitochondria, Liver; NADP; Niacinamide; Oxidoreductases; Pentosephosphates; Phosphogluconate Dehydrogenase; Proadifen; Rats; Sex Factors; Species Specificity; Spectrophotometry | 1970 |
Metabolism of ethanol by rat liver microsomal enzymes.
Topics: Amines; Animals; Azides; Barium; Bile Acids and Salts; Cyanides; Digitalis Glycosides; Ethanol; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Male; Metabolism; Microsomes, Liver; NADP; Oxides; Potassium; Proadifen; Pyrazoles; Rats; Saponins; Sodium; Spirostans; Triazoles; Ultracentrifugation | 1970 |
Oxygen uptake by microsomal preparations from the housefly, Musca domestica.
Topics: Animals; Anisoles; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Dioxoles; Houseflies; Hydrogen-Ion Concentration; Kinetics; Mercury; Microsomes; NAD; NADP; Nitro Compounds; Organometallic Compounds; Oxygen Consumption; Polarography; Potassium; Proadifen; Sulfhydryl Reagents; Sulfonic Acids; Sulfoxides | 1971 |
The stimulatory effects of carbon tetrachloride on peroxidative reactions in rat liver fractions in vitro. Interaction sites in the endoplasmic reticulum.
Topics: Aldehydes; Aminopyrine; Animals; Carbon Monoxide; Carbon Tetrachloride; Chloromercuribenzoates; Cytochromes; Electron Transport; Endoplasmic Reticulum; In Vitro Techniques; Lipid Metabolism; Liver; Malonates; Microsomes, Liver; NADP; Niacinamide; Peroxides; Proadifen; Rats | 1971 |
Formation of a factor lethal for S. typhimurium TA1530 and TA1531 on incubation of aflatoxin B 1 with rat liver microsomes.
Topics: Aflatoxins; Aniline Compounds; Animals; Carbon Monoxide; Caseins; Chromatography, Thin Layer; Depression, Chemical; Diet; Male; Microsomes, Liver; NADP; Nitrogen; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1971 |
Metabolism of the phenothiazine drug perazine by liver and lung microsomes from various species.
Topics: Animals; Cats; Chromatography, Thin Layer; Cytochromes; Dealkylation; Guinea Pigs; Hydroxylation; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxides; Phenothiazines; Proadifen; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfoxides; Swine; Tranquilizing Agents | 1971 |
3-Hydroxylation of coumarin or 4-methylcoumarin by rat-liver microsomes and its induction by 4-methylcoumarin given orally.
Topics: Animals; Coumarins; Dactinomycin; Enzyme Induction; Female; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Phospholipases; Proadifen; Proteins; Rats; Surface-Active Agents | 1970 |
The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.
Topics: Alkaloids; Animals; Calcium; Carbon Monoxide; DDT; Diet; Kinetics; Lung; Magnesium; Manganese; Microsomes; Microsomes, Liver; Models, Biological; NADP; Niacinamide; Oxides; Oxygen; Phenobarbital; Proadifen; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1971 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs.
Topics: Amitriptyline; Animals; Carbon Isotopes; Carbon Monoxide; Chlorpromazine; Cyclic N-Oxides; Cytochromes; Dealkylation; Desipramine; Horses; Imipramine; Kinetics; Liver; Male; NADP; Organ Specificity; Oxidation-Reduction; Proadifen; Rats; Species Specificity; Subcellular Fractions; Swine; Tetrazolium Salts | 1972 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
NADPH-dependent cleavage of carbamates.
Topics: Administration, Oral; Animals; Bees; Carbamates; Coleoptera; Diptera; Glucosephosphate Dehydrogenase; Glucosephosphates; Houseflies; Hydrolysis; In Vitro Techniques; Injections, Intraperitoneal; Insecticides; Metyrapone; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Piperonyl Butoxide; Proadifen; Tritium | 1971 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport; Endoplasmic Reticulum; Ethionine; Fatty Liver; Glucose-6-Phosphatase; Histocytochemistry; Liver; Macaca; Male; Microsomes, Liver; NADP; Necrosis; Oxidoreductases; Phenazines; Phenobarbital; Proadifen; Protein Deficiency; Rats; Rats, Inbred Strains | 1972 |
Monooxygenase drug metabolizing activity in CaCl 2 -aggregated hepatic microsomes from rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Calcium Chloride; Carbon Monoxide; Chlorine; Dronabinol; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1972 |
A comparative study of the hepatic and pulmonary microsomal mixed-function oxidase systems in the rabbit.
Topics: Aniline Compounds; Animals; Benzphetamine; Biphenyl Compounds; Buffers; Cytochrome c Group; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Kinetics; Liver; Lung; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Oxidoreductases, N-Demethylating; Proadifen; Proteins; Rabbits; Spectrophotometry | 1972 |
In vitro activation of isophosphamide (NSC-109724), a new oxazaphosphorine, by rat liver microsomes.
Topics: Alkylating Agents; Alkylation; Aminopyrine; Aniline Compounds; Animals; Cyclic P-Oxides; Cyclophosphamide; Dealkylation; DNA; Enzyme Activation; Ethylamines; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; NADP; Oxazines; Oxidoreductases; Phenobarbital; Phosphoranes; Proadifen; Proteins; Rats; RNA | 1972 |
Xenobiotic metabolism by alveolar type II cells isolated from rabbit lung.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Coumarins; Cytochrome P-450 CYP2A6; Cytochromes; In Vitro Techniques; Male; Mixed Function Oxygenases; NAD; NADP; Proadifen; Pulmonary Alveoli; Rabbits | 1981 |
Intact rat liver nuclei catalyze adriamycin irreversible interactions with DNA and nuclear proteins.
Topics: Animals; Cell Nucleus; DNA; Doxorubicin; Kinetics; Liver; Male; NADP; Nucleoproteins; Proadifen; Rats; Rats, Inbred Strains | 1983 |
The N-oxidation of benzamidines in vitro.
Topics: Amidines; Animals; Benzamidines; In Vitro Techniques; Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Proadifen; Rabbits | 1983 |
Inhibition of mitochondrial oxidative metabolism by SKF-525A in intact cells and isolated mitochondria.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cytochrome b Group; Electron Transport; Energy Metabolism; Liver; Male; Mitochondria, Liver; NAD; NADP; Oxygen Consumption; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Characteristics of the activation of cyclophosphamide to a mutagen by rat liver.
Topics: Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Flavonoids; In Vitro Techniques; Liver; Male; Metyrapone; Mutagens; NADP; Phenobarbital; Proadifen; Rats; Salmonella typhimurium | 1980 |
Chemical and biochemical characteristics of O-demethylation of chlorotrianisene in the rat.
Topics: Animals; Chemical Phenomena; Chemistry; Chlorotrianisene; Dealkylation; Female; Male; Metyrapone; Microsomes, Liver; NADP; Proadifen; Rats; Rats, Inbred Strains | 1981 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Lipid peroxidation and chemiluminescence during naproxen metabolism in rat liver microsomes.
Topics: Animals; Antimutagenic Agents; Antioxidants; Ascorbic Acid; Cobalt; Electrophoresis, Polyacrylamide Gel; Ferrous Compounds; Histidine; Lipid Peroxidation; Luminescent Measurements; Magnesium Chloride; Male; Microsomes, Liver; Molecular Weight; NADP; Naproxen; Piperonyl Butoxide; Proadifen; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Vitamin E | 1994 |
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 1994 |
Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.
Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Genetic Variation; Humans; Isomerism; Ketoconazole; Male; Microsomes, Liver; Middle Aged; NADP; Proadifen; Tamoxifen | 1994 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species.
Topics: Animals; Catalase; Cytochrome P-450 Enzyme System; Ethanol; Glutathione Peroxidase; Male; Microsomes, Liver; NADP; Pentetic Acid; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Toluene | 1994 |
Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carmustine; Coenzymes; Cyclophosphamide; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Female; Glutathione Transferase; Ifosfamide; Liver; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Phosphoramide Mustards; Proadifen; Rats | 1993 |
Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens.
Topics: Animals; Cricetinae; Cytochrome P-450 Enzyme System; Equilenin; Estrogens; Estrone; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mesocricetus; Microsomes, Liver; NADP; Naphthols; Proadifen | 1997 |
Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Topics: Acrylonitrile; Animals; Benzimidazoles; Cyanides; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Hydrogen-Ion Concentration; Kidney; Male; Methylcholanthrene; Microsomes; NADP; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfhydryl Compounds; Temperature | 1999 |
Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes.
Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Kinetics; Luminescent Measurements; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Rats; Rats, Wistar; Salicylic Acid; Thiobarbituric Acid Reactive Substances | 2002 |
In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS.
Topics: Amines; Animals; Antiparkinson Agents; Chromatography, Liquid; Enzyme Inhibitors; Heating; Hydrogen-Ion Concentration; In Vitro Techniques; Methimazole; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygenases; Proadifen; Rats; Selegiline; Spectrometry, Mass, Electrospray Ionization | 2004 |
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Topics: Animals; Antioxidants; Benzoquinones; Catecholamines; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione Disulfide; Hepatocytes; Imidazolines; Iron Chelating Agents; Ketoconazole; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Metyrapone; Molecular Structure; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances | 2006 |
2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol.
Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Microsomes, Liver; NADP; Proadifen; Valerates | 2008 |
Microsomal oxidative damage promoted by acetaminophen metabolism.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Catechin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Glutathione Transferase; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Sprague-Dawley | 2011 |