Page last updated: 2024-08-16

proadifen and methimazole

proadifen has been researched along with methimazole in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's5 (35.71)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Ruse, MJ; Waring, RH2
Hanzlik, RP; Traiger, GJ; Vyas, KP1
Kuroiwa, Y; Yamada, Y; Yamamoto, T; Yoshida, T1
Kammerer, RC; Lampe, MA1
Gooderham, NJ; Gorrod, JW1
Paxton, JW; Robertson, IG; Schlemper, B; Siegers, DJ1
Bland, TJ; Robertson, IG1
Cha, YN; Chung, WG1
Cha, YN; Chung, WG; Lee, WK; Park, CS; Roh, HK1
Ha, H; Han, MY; Han, SS; Jeong, TC; Kim, EJ; Koh, WS; Lee, JW; Lee, M; Shin, KD1
Damani, LA; Nnane, IP1
Igarashi, K; Kasuya, F; Katagi, M; Nishikawa, M; Tsuchihashi, H; Tsutsumi, H1

Other Studies

14 other study(ies) available for proadifen and methimazole

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The S-oxidation of thioamides by rat liver microsomes.
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: Amines; Animals; Ethionamide; Kinetics; Male; Methimazole; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains

1991
The effect of methimazole on thioamide bioactivation and toxicity.
    Toxicology letters, 1991, Volume: 58, Issue:1

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Ethionamide; Liver; Male; Methimazole; Microsomes, Liver; Niacinamide; Organ Size; Proadifen; Rats; Rats, Inbred Strains; Reference Values

1991
Effect of inhibitors of alpha-naphthylisothiocyanate-induced hepatotoxicity on the in vitro metabolism of alpha-naphthylisothiocyanate.
    Chemico-biological interactions, 1985, Volume: 52, Issue:3

    Topics: 1-Naphthylisothiocyanate; Administration, Oral; Aminopyrine; Animals; Bilirubin; Biotransformation; Chromatography, Gas; Ditiocarb; Ethionamide; Hyperbilirubinemia; Imidazoles; Kinetics; Male; Methimazole; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Thiocyanates

1985
Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:2

    Topics: Amphetamine; Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxylation; In Vitro Techniques; Male; Methamphetamine; Methimazole; Methylcholanthrene; Microsomes, Liver; Monoamine Oxidase Inhibitors; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline

1986
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
    Carcinogenesis, 1987, Volume: 8, Issue:10

    Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole

1987
Routes to the formation of N-methyl-4-aminophenol, a metabolite of N,N-dimethylaniline.
    Advances in experimental medicine and biology, 1981, Volume: 136 Pt B

    Topics: Amines; Aminophenols; Aniline Compounds; Animals; Biotransformation; Carbon Monoxide; Guinea Pigs; Kinetics; Male; Methimazole; Microsomes, Liver; Polychlorinated Biphenyls; Proadifen; Structure-Activity Relationship; Superoxide Dismutase

1981
Rat hepatocyte-mediated metabolism of the experimental anti-tumour agent N-[2'-(dimethylamino)ethyl]acridine-4-carboxamide.
    Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:4

    Topics: Acridines; Aminoacridines; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Glucuronates; In Vitro Techniques; Liver; Male; Methimazole; Proadifen; Rats; Rats, Wistar

1993
Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide.
    Biochemical pharmacology, 1993, May-25, Volume: 45, Issue:10

    Topics: Acridines; Acridones; Aldehyde Oxidase; Aldehyde Oxidoreductases; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cimetidine; Cytosol; Kinetics; Liver; Male; Methimazole; Metyrapone; Microsomes, Liver; NAD; Proadifen; Rats; Rats, Wistar

1993
Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes.
    Biochemical and biophysical research communications, 1997, Jun-27, Volume: 235, Issue:3

    Topics: Animals; Biotransformation; Caffeine; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methimazole; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Proadifen; Rats; Rats, Sprague-Dawley; Species Specificity; Theobromine; Theophylline

1997
Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450.
    Japanese journal of pharmacology, 2000, Volume: 84, Issue:2

    Topics: Animals; Antithyroid Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Histamine H2 Antagonists; Humans; In Vitro Techniques; Isoenzymes; Male; Methimazole; Microsomes, Liver; Oxygenases; Proadifen; Ranitidine; Rats; Rats, Sprague-Dawley; Recombinant Proteins

2000
Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression.
    Toxicology letters, 2003, Jan-13, Volume: 136, Issue:3

    Topics: Animals; Cell Division; Enzyme Inhibitors; Erythrocytes; Female; Immunoglobulin M; Immunosuppressive Agents; Interleukin-2; Lymphocytes; Methimazole; Mice; Mice, Inbred BALB C; Microsomes, Liver; Monoamine Oxidase; Proadifen; Sheep; Spleen; Thioacetamide

2003
Involvement of cytochrome P450 and the flavin-containing monooxygenase(s) in the sulphoxidation of simple sulphides in human liver microsomes.
    Life sciences, 2003, Jun-06, Volume: 73, Issue:3

    Topics: Chlorobenzenes; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Humans; In Vitro Techniques; Methimazole; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Phenotype; Proadifen; Sulfides

2003
In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:10

    Topics: Amines; Animals; Antiparkinson Agents; Chromatography, Liquid; Enzyme Inhibitors; Heating; Hydrogen-Ion Concentration; In Vitro Techniques; Methimazole; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygenases; Proadifen; Rats; Selegiline; Spectrometry, Mass, Electrospray Ionization

2004