Page last updated: 2024-08-16

proadifen and methadone

proadifen has been researched along with methadone in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199011 (84.62)18.7374
1990's1 (7.69)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dalvie, D; Hu, Q; Jones, P; Obach, RS; Pryde, DC; Tran, TD1
Kraus, JL; Yaouanc, JJ1
Ho, TK; LaBella, FS; Pinsky, C1
Franklin, MR; Roberts, SM1
Bellward, GD; Gontovnick, LS; Ng, S1
Covault, HP; Hostetler, RM; Peterson, GR1
Bauer, J; Gerber, N; Gordon, P; Leger, RM; Lynn, RK; Smith, RG1
Bertolatus, JA; Donald, AG; Hixson, B; Shah, NS1
Bowman, ER; Brase, DA; Dewey, WL; Kachur, JF; Martin, BR; Rosemond, R; Welch, S1
Harbison, RD; James, RC1
Burkhalter, A; Masten, LW; Peterson, GR; Way, EL1
Gamage, RS; Robertson, IG1
ADLER, TK; VEATCH, RM; WAY, EL1

Other Studies

13 other study(ies) available for proadifen and methadone

ArticleYear
Aldehyde oxidase: an enzyme of emerging importance in drug discovery.
    Journal of medicinal chemistry, 2010, Dec-23, Volume: 53, Issue:24

    Topics: Aldehyde Oxidase; Animals; Drug Discovery; Humans; Models, Molecular; Organ Specificity; Oxidation-Reduction; Pharmaceutical Preparations; Pharmacokinetics; Species Specificity; Substrate Specificity

2010
Inhibition of the cytochrome P-450 multifunctional oxidase by N-propargyl analogs of SKF-525 A and acetylmethadol.
    European journal of drug metabolism and pharmacokinetics, 1979, Volume: 4, Issue:4

    Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme Inhibitors; Female; Flavins; Flavoproteins; Fluorometry; Kinetics; Male; Methadone; Methadyl Acetate; Mixed Function Oxygenases; Oxidoreductases; Proadifen; Rabbits; Rats; Time Factors

1979
Opiate properties of SKF 525A.
    Canadian journal of physiology and pharmacology, 1978, Volume: 56, Issue:4

    Topics: Analgesia; Animals; Injections, Intraventricular; Male; Methadone; Morphine; Naloxone; Narcotics; Proadifen; Rats; Reaction Time; Receptors, Opioid

1978
Modification of hepatic microsomal oxidative drug metabolism in rats by the opiate maintenance drugs acetylmethadol, propoxyphene, and methadone.
    Life sciences, 1979, Sep-03, Volume: 25, Issue:10

    Topics: Animals; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship

1979
The irreversible binding of benzo[a]pyrene to rat liver macromolecules in vivo and in vitro: effects of agents that influence benzo[a]pyrene metabolism.
    Canadian journal of physiology and pharmacology, 1979, Volume: 57, Issue:11

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cysteine; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione; In Vitro Techniques; Liver; Male; Methadone; Methylcholanthrene; Nucleic Acids; Proadifen; Protein Binding; Rats; Time Factors

1979
Acute inhibition of microsomal drug metabolism by propoxyphene in narcotic tolerant/dependent mice.
    Life sciences, 1978, Jun-19, Volume: 22, Issue:23

    Topics: Animals; Dextropropoxyphene; Drug Tolerance; Humans; Male; Methadone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Morphine Dependence; Oxidoreductases; Pentobarbital; Proadifen; Substance-Related Disorders

1978
The metabolism of d-, l- and dl-methadone in the isolated perfused rat liver.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 200, Issue:3

    Topics: Animals; Biotransformation; Half-Life; Isomerism; Liver; Methadone; Perfusion; Phenobarbital; Proadifen; Rats

1977
Tissue distribution of levo-methadone in nonpregnant and pregnant female and male mice: effect of SKF 525-A 1,2.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1

    Topics: Animals; Dealkylation; Female; Fetus; Male; Methadone; Mice; Organ Specificity; Pregnancy; Proadifen; Stereoisomerism; Stimulation, Chemical; Time Factors

1976
Comparison of the ability of opioid analgesics to increase endogenous opioid-like activity in the cerebrospinal fluid of rabbits.
    Life sciences, 1985, Dec-30, Volume: 37, Issue:26

    Topics: Animals; Biological Assay; Dextrorphan; Diazepam; Dose-Response Relationship, Drug; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Levorphanol; Male; Meperidine; Methadone; Nociceptors; Pentazocine; Pentobarbital; Proadifen; Rabbits; Time Factors

1985
Hepatic glutathione and hepatotoxicity: effects of cytochrome P-450 complexing compounds SKF 525-A, L-alpha acetylmethadol (LAAM), norLAAM, and piperonyl butoxide.
    Biochemical pharmacology, 1982, May-15, Volume: 31, Issue:10

    Topics: Alanine Transaminase; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Mesocricetus; Methadone; Methadyl Acetate; Mice; Mixed Function Oxygenases; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains

1982
Tolerance to methadone lethality and microsomal enzyme induction in mice tolerant to and dependent on morphine.
    Drug and alcohol dependence, 1980, Volume: 5, Issue:1

    Topics: Animals; Body Weight; Drug Tolerance; Enzyme Induction; Humans; Inactivation, Metabolic; Lethal Dose 50; Liver; Male; Methadone; Mice; Microsomes, Liver; Morphine; Morphine Dependence; Oxidoreductases, N-Demethylating; Proadifen

1980
Methadone: a potent inhibitor of rat liver aldehyde oxidase.
    Biochemical pharmacology, 1994, Feb-09, Volume: 47, Issue:3

    Topics: Acridines; Acridones; Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Dextropropoxyphene; Liver; Methadone; Proadifen; Rats

1994
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 145

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone; Mice; Morphine; Nalorphine; Pain; Pharmacology; Proadifen; Research; Seizures; Toxicology

1964