proadifen has been researched along with arachidonic acid in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lewis, DA; Miller, VM | 1 |
| Figueroa, R; Omar, HA; Omar, RA; Wolin, MS | 1 |
| Kim, HY; Salem, N; Sawazaki, S | 1 |
| Harbison, RG; Ignarro, LJ; Kadowitz, PJ; Wood, KS | 1 |
| Axelrod, J; Luini, AG | 1 |
| Harbison, RG; Hyman, AL; Ignarro, LJ; Kadowitz, PJ; McNamara, DB; Wolin, MS; Wood, KS | 1 |
| Abraham, NG; Bednar, M; Kraemer, R; Mullane, KM | 1 |
| Abraham, NG; Mullane, KM; Pinto, A | 2 |
| Dubbin, PN; Dusting, GJ; Macdonald, PS | 1 |
| Boeynaems, JM; Demolle, D; Van Coevorden, A | 1 |
| Berlin, T; Larsson, R; Moldéus, P; Olsson, LI; Ross, D | 1 |
| Abraham, NG; Dunn, MW; Masferrer, J; McGiff, JC; Schwartzman, ML | 1 |
| Chander, PN; Ferreri, NR; Ibraham, NG; McGiff, JC; Schwartzman, M | 1 |
| Bast, A; Bragt, PC; Parnham, MJ; Zijlstra, FJ | 1 |
| Gustafsson, JA; Hamberg, M; Mode, A; Tollet, P | 1 |
| Bend, JR; Knickle, LC | 1 |
| De Petrocellis, L; Di Marzo, V; Leitz, T; Muller, W | 1 |
| Conners, MS; Dunn, MW; Schwartzman, ML; Stoltz, RA | 1 |
| Ghosh, J; Myers, CE | 1 |
| Caron, N; Genard, J; Gulbis, E; Herman, A; Kramp, RA; Lejeune, C | 1 |
| Abdul-Karim, RW; Holland, JA; Johnson, DK; Lemanski, LF; Meyer, JW; Patel, V; Sauro, MD; Schillinger, KJ; Schmitt, ME; Small, RF; Ziegler, LM | 1 |
| Alfonso, A; Gill, DL; Graber, MN | 1 |
| Archuleta, I; Kluger, MJ; Kozak, A; Kozak, W; Mayfield, KP; Rudolph, K | 1 |
| Chiribiri, A; Gattullo, D; Pagliaro, P; Paolocci, N; Penna, C; Rastaldo, R | 1 |
| Krutetskaia, NI; Krutetskaia, ZI; Kurilova, LS; Lebedev, OE | 1 |
| Reiser, G; Sergeeva, M; Strokin, M; Ubl, JJ; Wang, H | 1 |
| Aronoff, DM; Boutaud, O; Kozak, A; Kozak, W | 1 |
| Kadiiska, MB; Mason, RP; Qian, SY; Towner, RA | 1 |
| Bao, S; Christofi, FL; Clanton, TL; Wright, VP; Zuo, L | 1 |
| Kodama, Y; Lv, X; Nakahata, N; Ohizumi, Y; Toriniwa, Y; Yoshida, M | 1 |
| Moreno, JJ; Nieves, D | 1 |
| Hosokawa, M; Kamata, K; Kobayashi, T; Matsumoto, T | 1 |
33 other study(ies) available for proadifen and arachidonic acid
| Article | Year |
|---|---|
Role of lipoxygenase and cytochrome P-450 in production of endothelium-derived relaxing factors in canine femoral veins.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arginine; Benzoquinones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Femoral Vein; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Piperidines; Proadifen | 1992 |
Properties of an endogenous arachidonic acid--elicited relaxing mechanism in human placental vessels.
Topics: Arachidonic Acid; Arginine; Blood Vessels; Cyclic GMP; Endothelium, Vascular; Female; Humans; Nitric Oxide; Placenta; Pregnancy; Proadifen; Vasodilation | 1992 |
Lipoxygenation in rat brain?
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Indomethacin; Kinetics; Lipoxygenase; Male; Masoprocol; Methoxsalen; Proadifen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains | 1991 |
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Bradykinin; Cattle; Endothelium; Enzyme Activation; Guanylate Cyclase; Hemoglobins; In Vitro Techniques; Methylene Blue; Nitric Oxide; Proadifen; Pulmonary Artery; Pulmonary Veins; Quinacrine; Solubility; Vasodilator Agents | 1986 |
Inhibitors of the cytochrome P-450 enzymes block the secretagogue-induced release of corticotropin in mouse pituitary tumor cells.
Topics: Adrenocorticotropic Hormone; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Corticotropin-Releasing Hormone; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Lipoxygenase Inhibitors; Mice; Oxygenases; Phospholipases A; Phospholipases A2; Pituitary Neoplasms; Proadifen | 1985 |
Differences in responsiveness of intrapulmonary artery and vein to arachidonic acid: mechanism of arterial relaxation involves cyclic guanosine 3':5'-monophosphate and cyclic adenosine 3':5'-monophosphate.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cattle; Cyclic AMP; Cyclic GMP; Endothelium; In Vitro Techniques; Methylene Blue; Muscle, Smooth, Vascular; Proadifen; Prostaglandins; Pulmonary Artery; Pulmonary Veins; Vasodilation | 1985 |
Arachidonic acid monooxygenase and lipoxygenase activities in polymorphonuclear leukocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dogs; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipoxygenase; Mixed Function Oxygenases; Neutrophils; Proadifen; Rats | 1987 |
Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Blood Vessels; Cobalt; Cytochrome P-450 Enzyme System; Drug Synergism; Endothelium; Fatty Acids; Indomethacin; Male; Methylcholanthrene; Oxygenases; Phenylephrine; Proadifen; Pulmonary Artery; Pyrazoles; Rabbits; Vasoconstriction; Vasodilation | 1986 |
Endothelium-dependent vasodilatation in bovine coronary arteries: calcium dependence and inhibition by proadifen.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Coronary Vessels; Endothelium; In Vitro Techniques; Proadifen; Prostaglandin Endoperoxides, Synthetic; Vasodilation | 1986 |
Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Coronary Vessels; Cytochrome P-450 Enzyme System; Dinoprost; Dogs; Endothelium; In Vitro Techniques; Indomethacin; Male; Methylcholanthrene; Muscle Contraction; Muscle Relaxation; Proadifen; Prostaglandins F | 1987 |
Stimulation of vascular prostacyclin by SKF 525-A (proadifen) and related compounds.
Topics: Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Vessels; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry; Endothelium; Epoprostenol; Humans; Kinetics; Proadifen; Rabbits; Structure-Activity Relationship; Umbilical Veins | 1987 |
Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney.
Topics: Acetaminophen; Aminophenols; Animals; Arachidonic Acid; Arachidonic Acids; Glutathione; Glutathione Disulfide; Humans; Indomethacin; Kidney; Kinetics; Linolenic Acids; Lipid Peroxides; Male; Metyrapone; Microsomes; Models, Chemical; NADP; Phenetidine; Proadifen; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rabbits | 1985 |
Cytochrome P450 dependent metabolism of arachidonic acid in bovine corneal epithelium.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cattle; Chromatography, Thin Layer; Cornea; Cytochrome P-450 Enzyme System; Epithelium; Microsomes; NADP; Proadifen | 1985 |
Arachidonic acid metabolism in a cell suspension isolated from rabbit renal outer medulla.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Separation; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kidney Medulla; Kidney Tubules; Loop of Henle; Male; Proadifen; Prostaglandins; Rabbits | 1984 |
Comparison of the effects of inhibitors of cytochrome P-450-mediated reactions on human platelet aggregation and arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Butanones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Malondialdehyde; Metyrapone; Microsomes, Liver; Platelet Aggregation; Proadifen; Rats; Thromboxanes | 1981 |
Growth hormone signaling leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Diglycerides; Enzyme Activation; Gene Expression Regulation; Growth Hormone; Insulin-Like Growth Factor I; Ketoconazole; Lactams, Macrocyclic; Liver; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Proadifen; Protein-Tyrosine Kinases; Quinacrine; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Verapamil | 1995 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
Enantiospecific synthesis of bioactive hydroxyeicosatetraenoic acids (HETEs) in Hydra magnipapillata.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Cell Division; Cytosol; Hydra; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Masoprocol; Proadifen; Reproduction, Asexual; Stereoisomerism | 1994 |
Effect of metabolic inhibitors on arachidonic acid metabolism in the corneal epithelium: evidence for cytochrome P450-mediated reactions.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cattle; Chromatography, High Pressure Liquid; Clotrimazole; Cornea; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epithelium; Hydroxyeicosatetraenoic Acids; Lipoxygenase Inhibitors; Microsomes; Proadifen; Rabbits | 1994 |
Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Cell Division; Cyclooxygenase Inhibitors; Eicosanoids; Enzyme Inhibitors; Flavanones; Flavonoids; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indoles; Lipoxygenase Inhibitors; Male; Masoprocol; Proadifen; Prostatic Neoplasms; Tumor Cells, Cultured | 1997 |
Differential effects of sulindac on renal hemodynamics and function in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Glomerular Filtration Rate; Kidney; Male; Potassium; Proadifen; Prostaglandins; Rats; Rats, Wistar; Renal Circulation; Renin; Sodium; Sulindac; Water | 1997 |
Low-density lipoprotein stimulated peroxide production and endocytosis in cultured human endothelial cells: mechanisms of action.
Topics: Acetophenones; Arachidonic Acid; Cells, Cultured; Cholesterol, LDL; Cyclooxygenase Inhibitors; Endocytosis; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydrogen Peroxide; Indomethacin; Masoprocol; Methoxsalen; NADPH Oxidases; Phospholipases A; Phospholipases A2; Proadifen; Reactive Oxygen Species; Second Messenger Systems; Stimulation, Chemical | 1997 |
Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Cycle; Cell Division; Cells, Cultured; Cricetinae; Enzyme Inhibitors; Indoles; Masoprocol; Metyrapone; Muscle, Smooth; Proadifen; Signal Transduction; Thapsigargin | 1997 |
Inhibitors of alternative pathways of arachidonate metabolism differentially affect fever in mice.
Topics: Animals; Antioxidants; Arachidonic Acid; Body Temperature; Body Temperature Regulation; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Fever; Indomethacin; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Masoprocol; Mice; Proadifen; Pyrazoles; Time Factors; Umbelliferones | 1998 |
Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Bradykinin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Octoxynol; Proadifen; Rats; Rats, Wistar; Tachyphylaxis; Triazoles; Ventricular Function, Left | 2001 |
[Effect of arachidonic and other fatty acids on the intracellular calcium concentration and calcium signaling in peritoneal macrophages].
Topics: Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Indoles; Ion Transport; Linoleic Acid; Macrophages, Peritoneal; Proadifen; Rats; Thapsigargin | 2001 |
Arachidonic acid in astrocytes blocks Ca(2+) oscillations by inhibiting store-operated Ca(2+) entry, and causes delayed Ca(2+) influx.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Astrocytes; Brain; Calcium; Calcium Signaling; Cell Membrane; Cells, Cultured; Electric Capacitance; Enzyme Inhibitors; Gadolinium; Indoles; Proadifen; Rats; Reaction Time; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Serum Albumin, Bovine | 2003 |
11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Lipopolysaccharides; Male; Monocytes; Proadifen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
In vivo identification of aflatoxin-induced free radicals in rat bile.
Topics: Aflatoxin B1; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Bile; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Deferoxamine; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Gadolinium; Iron Chelating Agents; Male; Nitrogen Oxides; Proadifen; Pyridines; Rats; Rats, Sprague-Dawley; Spin Labels; Spin Trapping | 2003 |
Lipoxygenase-dependent superoxide release in skeletal muscle.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Caffeic Acids; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Lipoxygenase Inhibitors; Male; Muscle, Skeletal; Proadifen; Rats; Rats, Sprague-Dawley; Superoxides | 2004 |
Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dinoprostone; Enzyme Activation; Oleanolic Acid; Oxygenases; Proadifen; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger | 2006 |
Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth.
Topics: Animals; Arachidonic Acid; Cell Cycle; Cell Line; Cell Proliferation; Culture Media; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Enzyme Inhibitors; Fibroblasts; Hydroxyeicosatetraenoic Acids; Leukotriene Antagonists; Lipoxygenase Inhibitors; Mice; Phosphatidylinositol 3-Kinases; Proadifen; Proto-Oncogene Proteins c-akt | 2006 |
Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; In Vitro Techniques; Indomethacin; Kidney; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Perfusion; Proadifen; Rats; Rats, Wistar; Regional Blood Flow; Streptozocin | 2006 |